Clinical, signs & Symptoms Sentence Context
Table 1. Analysis of context sentence of 24056 absracts clustered as Clinical, signs & Symptoms.
| PMID | Gene Context Sentence | ePubDate |
|---|---|---|
| 31944312 | Conventional diagnostic tests, such as the assays for rapid detection of antiviral antibodies or viral antigens, are widely used in many clinical laboratories. | 2020-03-19 |
| 31967265 | Despite the severity of the clinical condition, he evolved favorably. | 2020-01-23 |
| 31981224 | In this review, we provide an update on CoV infections and relevant diseases, particularly the host defense against CoV-induced inflammation of lung tissue, as well as the role of the innate immune system in the pathogenesis and clinical treatment. | 2020-03-19 |
| 31986261 | In this study, we report the epidemiological, clinical, laboratory, radiological, and microbiological findings of five patients in a family cluster who presented with unexplained pneumonia after returning to Shenzhen, Guangdong province, China, after a visit to Wuhan, and an additional family member who did not travel to Wuhan. […] Five family members (aged 36-66 years) presented with fever, upper or lower respiratory tract symptoms, or diarrhoea, or a combination of these 3-6 days after exposure. […] Older patients (aged >60 years) had more systemic symptoms, extensive radiological ground-glass lung changes, lymphopenia, thrombocytopenia, and increased C-reactive protein and lactate dehydrogenase levels. | 2020-03-13 |
| 31986264 | We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of these patients. […] Common symptoms at onset of illness were fever (40 [98%] of 41 patients), cough (31 [76%]), and myalgia or fatigue (18 [44%]); less common symptoms were sputum production (11 [28%] of 39), headache (three [8%] of 38), haemoptysis (two [5%] of 39), and diarrhoea (one [3%] of 38). […] Major gaps in our knowledge of the origin, epidemiology, duration of human transmission, and clinical spectrum of disease need fulfilment by future studies. | 2020-03-13 |
| 31992387 | Through coordination between academic and public laboratories, we confirmed assay exclusivity based on 297 original clinical specimens containing a full spectrum of human respiratory viruses. | 2020-02-19 |
| 31994742 | Fever (64.7%) and cough (52.9%) were the most common first symptoms among those who died. | 2020-03-19 |
| 31996437 | Recently, a novel coronavirus (2019-nCoV) has emerged from Wuhan, China, causing symptoms in humans similar to those caused by severe acute respiratory syndrome coronavirus (SARS-CoV). | 2020-03-23 |
| 31996494 | However, the efficacy and safety of these drugs for 2019- nCoV still need to be further confirmed by clinical experiments. | 2020-03-18 |
| 32004165 | We collected clinical data and bronchoalveolar lavage (BAL) specimens from five patients with severe pneumonia from Jin Yin-tan Hospital of Wuhan, Hubei province, China. | 2020-02-12 |
| 32004427 | We report the first case of 2019-nCoV infection confirmed in the United States and describe the identification, diagnosis, clinical course, and management of the case, including the patient’s initial mild symptoms at presentation with progression to pneumonia on day 9 of illness. […] This case highlights the importance of close coordination between clinicians and public health authorities at the local, state, and federal levels, as well as the need for rapid dissemination of clinical information related to the care of patients with this emerging infection. | 2020-03-16 |
| 32007143 | We aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia. […] Cases were confirmed by real-time RT-PCR and were analysed for epidemiological, demographic, clinical, and radiological features and laboratory data. […] Patients had clinical manifestations of fever (82 [83%] patients), cough (81 [82%] patients), shortness of breath (31 [31%] patients), muscle ache (11 [11%] patients), confusion (nine [9%] patients), headache (eight [8%] patients), sore throat (five [5%] patients), rhinorrhoea (four [4%] patients), chest pain (two [2%] patients), diarrhoea (two [2%] patients), and nausea and vomiting (one [1%] patient). | 2020-03-13 |
| 32007627 | We have described the discovery, emergence, genomic characteristics, and clinical diagnostics of 2019-nCoV. | 2020-03-18 |
| 32020836 | The two patients shared common clinical features including fever, cough, and multiple ground-glass opacities in the bilateral lung field with patchy infiltration. | 2020-03-16 |
| 32020915 | Herein, we present on an overview of the currently available information on the pathogenesis, epidemiology, clinical presentation, diagnosis, and treatment of this virus. | 2020-04-13 |
| 32023681 | The clinical features include fever, coughing, shortness of breath, and inflammatory pulmonary infiltration revealed by X ray. | 2020-02-05 |
| 32023682 | The outbreak of pneumonia caused by the novel coronavirus 2019-nCoV in Wuhan, Hubei province of China, at the end of 2019 shaped tremendous challenges to China’s public health and clinical treatment. […] The virus belongs to the β genus Coronavirus in the family Corornaviridae, and is closely related to SARS-CoV and MERS-CoV, causing severe symptoms of pneumonia. […] After the outbreak of this disease, Chinese scientists invested a lot of energy to carry out research by developing rapid diagnostic reagents, identifying the characters of the pathogen, screening out clinical drugs that may inhibit the virus, and are rapidly developing vaccines. | 2020-02-05 |
| 32023684 | Based on current studies, the author summarized the clinical characteristics and evolution of the novel viral pneumonia, and proposed the key points of diagnosis and treatment, the scientific management of both confirmed and suspected cases, and the scientific management of disease prevention and control. | 2020-02-05 |
| 32023685 | Antiviral drugs commonly used in clinical practice, including neuraminidase inhibitors (oseltamivir, paramivir, zanamivir, etc.), ganciclovir, acyclovir and ribavirin, are invalid for 2019-nCoV and not recommended. […] But the efficacy and safety of these drugs for 2019-nCoV pneumonia patients need to be assessed by further clinical trials. | 2020-02-05 |
| 32023686 | The novel coronavirus has the characteristics of rapid transmission, atypical clinical symptoms, and easy to affect both lungs, leading to missed diagnosis and misdiagnosis, as well as difficult to detection and assessment at early stage. | 2020-02-05 |
| 32026148 | Following the latest National recommendations for diagnosis and treatment of pneumonia caused by 2019-nCoV (the 4th edition) and current status of clinical practice in Zhejiang Province, recommendations for the diagnosis and treatment of respiratory infection caused by 2019-nCoV for children were drafted by the National Clinical Research Center for Child Health, the National Children’s Regional Medical Center, Children’s Hospital, Zhejiang University School of Medicine to further standardize the protocol for diagnosis and treatment of respiratory infection in children caused by 2019-nCoV. | 2020-02-06 |
| 32026671 | Objective: To analyze the clinical characteristics of 2019 novel coronavirus (2019-nCoV) pneumonia and to investigate the correlation between serum inflammatory cytokines and severity of the disease. Methods: 29 patients with 2019-ncov admitted to the isolation ward of Tongji hospital affiliated to Tongji medical college of Huazhong University of Science and Technology in January 2020 were selected as the study subjects. […] Clinical data were collected and the general information, clinical symptoms, blood test and CT imaging characteristics were analyzed. […] The expression levels of inflammatory cytokines and other markers in the serum of each group were detected, and the changes of these indicators of the three groups were compared and analyzed, as well as their relationship with the clinical classification of the disease. Results: (1) The main symptoms of 2019-nCoV pneumonia was fever (28/29) with or without respiratory and other systemic symptoms. […] However, there were no statistically significant differences in serum levels of tumor necrosis factor-alpha (TNF-α), IL-1, IL-8, IL-10, hs-CRP, lymphocyte count and LDH among the three groups (P>0.05). Conclusion: The clinical characteristics of 2019-nCoV pneumonia are similar to those of common viral pneumonia. | 2020-02-06 |
| 32027573 | BackgroundThe chest CT findings of patients with 2019 Novel Coronavirus (2019-nCoV) pneumonia have not previously been described in detail.PurposeTo investigate the clinical, laboratory, and imaging findings of emerging 2019-nCoV pneumonia in humans.Materials and MethodsFifty-one patients (25 men and 26 women; age range 16-76 years) with laboratory-confirmed 2019-nCoV infection by using real-time reverse transcription polymerase chain reaction underwent thin-section CT. […] The imaging findings, clinical data, and laboratory data were evaluated.ResultsFifty of 51 patients (98%) had a history of contact with individuals from the endemic center in Wuhan, China. […] Fever (49 of 51, 96%) and cough (24 of 51, 47%) were the most common symptoms. | 2020-03-20 |
| 32030925 | We report the epidemiological and clinical features of the first patient with 2019-nCoV pneumonia imported into Korea from Wuhan. | 2020-03-16 |
| 32031570 | The number of cases has increased rapidly but information on the clinical characteristics of affected patients is limited. […] To describe the epidemiological and clinical characteristics of NCIP. […] Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. […] Common symptoms included fever (136 [98.6%]), fatigue (96 [69.6%]), and dry cough (82 [59.4%]). | 2020-03-13 |
| 32033064 | All passengers were screened upon arrival in Japan for symptoms consistent with novel coronavirus (2019-nCoV) infection and tested for presence of the virus. | 2020-03-20 |
| 32035428 | It is extremely important to disinfect ophthalmic examination instruments and protect ophthalmic medical care during the epidemic period to reduce cross-infection in clinical practice and reduce the infection risk of ophthalmic medical staff. (Chin J Ophthalmol, 2020, 56: 0001). | 2020-02-08 |
| 32035430 | Based on the clinical data of novel coronavirus pneumonia (NCP), as well as the dada from previous clinical studies and the recommendations from the Extracorporeal Life Support Organization (ELSO), the committee board of the Chinese Society of Extracorporeal Life Support (CSECLS) made this recommendations to guide clinical ECMO application in the patients with NCP. | 2020-02-09 |
| 32037389 | We report here the clinical characteristics and therapeutic procedure for four patients with mild or severe 2019-nCoV pneumonia admitted to Shanghai Public Health Clinical Center. […] After treatment, three patients gained significant improvement in pneumonia associated symptoms, two of whom were confirmed 2019-nCoV negative and discharged, and one of whom was virus negative at the first test. | 2020-03-18 |
| 32044814 | This study aims to investigate its epidemiologic history, and analyze the clinical characteristics, treatment regimens, and prognosis of patients infected with 2019-nCoV during this outbreak. […] Clinical data from 137 2019-nCoV-infected patients admitted to the respiratory departments of the respiratory departments of nine tertiary hospitals in Hubei province from December 30, 2019 to January 24, 2020 were retrospectively collected, including general status, clinical manifestations, laboratory test results, imaging characteristics, and treatment regimens. […] Major initial symptoms included fever (112/137, 81.8%), coughing (66/137, 48.2%), and muscle pain or fatigue (44/137, 32.1%), with other, less typical initial symptoms observed at low frequency, including heart palpitations, diarrhea, and headache. […] The risk of death was primarily associated with age, underlying chronic diseases, and median interval from the appearance of initial symptoms to dyspnea. | 2020-03-02 |
| 32046137 | A deterministic compartmental model was devised based on the clinical progression of the disease, epidemiological status of the individuals, and intervention measures. | 2020-03-20 |
| 32048163 | Here we report the epidemiological, clinical, laboratory, and radiological characteristics, as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen, China. | 2020-03-19 |
| 32048815 | Based on the susceptible-exposed-infected-removed (SEIR) compartment model and the assumption that the infectious cases with symptoms occurred before 26 January, 2020 are resulted from free propagation without intervention, we estimate the basic reproduction number of 2019-nCoV according to the reported confirmed cases and suspected cases, as well as the theoretical estimated number of infected cases by other research teams, together with some epidemiological determinants learned from the severe acute respiratory syndrome (SARS). | 2020-03-16 |
| 32049601 | A combination of repeated swab tests and CT scanning may be helpful when for individuals with high clinical suspicion of nCoV infection but negative RT-PCR screening. | 2020-02-12 |
| 32049687 | To promptly identify patients and prevent further spreading, physicians should be aware of travel or contact history for patients with compatible symptoms. | 2020-02-12 |
| 32050635 | In order to assess the potential of the Wuhan 2019-nCoV to cause maternal, fetal and neonatal morbidity and other poor obstetrical outcomes, this communication reviews the published data addressing the epidemiological and clinical effects of SARS, MERS, and other coronavirus infections on pregnant women and their infants. […] Recommendations are also made for the consideration of pregnant women in the design, clinical trials, and implementation of future 2019-nCoV vaccines. | 2020-03-23 |
| 32051073 | In order to further standardize and enhance the clinical management of 2019-nCoV infection in children, reduce the incidence, and decrease the number of severe cases, we have formulated this diagnosis and treatment recommendation according to the recent information at home and abroad. | 2020-02-19 |
| 32053470 | Maximum lung involved peaked at approximately 10 days (with the calculated total CT score of 6) from the onset of initial symptoms (R2=0.25), p<0.001). […] Conclusion In patients recovering from COVID-19 pneumonia (without severe respiratory distress during the disease course), lung abnormalities on chest CT showed greatest severity approximately 10 days after initial onset of symptoms. | 2020-02-13 |
| 32053579 | As of January 31, 2020, CDC had responded to clinical inquiries from public health officials and health care providers to assist in evaluating approximately 650 persons thought to be at risk for 2019-nCoV infection. | 2020-02-18 |
| 32054787 | Prophylactic remdesivir treatment initiated 24 h prior to inoculation completely prevented MERS-CoV-induced clinical disease, strongly inhibited MERS-CoV replication in respiratory tissues, and prevented the formation of lung lesions. […] Therapeutic remdesivir treatment initiated 12 h postinoculation also provided a clear clinical benefit, with a reduction in clinical signs, reduced virus replication in the lungs, and decreased presence and severity of lung lesions. […] The data presented here support testing of the efficacy of remdesivir treatment in the context of a MERS clinical trial. | 2020-04-01 |
| 32056407 | He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. […] Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. | 2020-03-16 |
| 32057212 | Novel coronavirus pneumonia (NCP) is a highly infectious disease, has a long incubation period and a variety of clinical manifestations, which has a significant impact on public health and life. […] In order to implement the central government’s decision-making deployment and defeat the NCP as soon as possible, we had focused on the key points in the clinical work of general surgery according to latest relevant guidelines, literature and experience in epidemic prevention. | 2020-02-14 |
| 32057575 | Like the rH120-infected group and in contrast to the rIBYZ-infected group, no mortality, clinical signs, or lesions were observed in the lungs or kidneys of young chickens inoculated with rH120-S1/YZ. | 2020-02-15 |
| 32061066 | Objective: To summarize and analyze the clinical and imaging characteristics of patients with 2019 novel coronavirus pneumonia in the early stage in Beijing. Methods: A retrospective analysis of clinical and imaging data of 9 patients with 2019 novel coronavirus infection diagnosed in one fever clinicic in Beijing from January 18, 2020 to February 3, 2020. Results: 5 male and 4 female was included in those 9 patients, whose median age was 36 years, and the age range from 15 to 49 years. 8 of these patients had no underlying disease and one suffered from diabetes. 7 patients had a history of travel to Wuhan City or Hubei Province, and one patient was a medical staff. […] The clinical manifestations were fever in 8 cases (8/9) , dry cough in 5 cases (5/9) , pharyngalgia in 4 cases (4/9) , fatigue in 4 cases (4/9) , body soreness in 4 cases (4/9) , and blocked or watery nose in 1 case (1/9) . […] The clinical manifestations are fever and cough. | 2020-02-15 |
| 32061198 | Animal studies have shown that RAS inhibitors could effectively relieve symptoms of acute severe pneumonia and respiratory failure. | 2020-02-15 |
| 32061200 | Objective: To explore imaging characteristics of children with 2019 novel coronavirus (2019-nCoV) infection. Methods: A retrospective analysis was performed on clinical data and chest CT images of 15 children diagnosed with 2019-nCoV. […] The clinical symptoms of children with 2019-nCoV infection are nonspecific. | 2020-02-16 |
| 32062875 | Objective: To describe the characteristics of clinical manifestations and epidemiology of children with 2019 novel coronavirus (2019-nCoV) infection. Methods: All 34 children with laboratory-confirmed 2019-nCoV infection by quantitative real-time reverse transcription-PCR through nasopharyngeal swab specimens were admitted to the Third People’s Hospital of Shenzhen from January 19 to Febuary 7, 2020. […] Clinical data and epidemiological history of these patients were retrospectively collected and analyzed. Results: Among the 34 cases, 14 were males, and 20 were females. […] These patients could be categorized into different clinical types, including 22 (65%) common cases, 9 (26%) mild cases and 3 (8.8%) asymptomatic cases. […] The most common symptoms were fever (17 cases, 50%) and cough (13 cases, 38% ). […] Further following up was need. Conclusions: The clinical manifestations in children with 2019-nCoV infection are non-specific and are milder than that in adults. | 2020-02-26 |
| 32062957 | Objective: To investigate the clinical characteristics of medical staff with novel coronavirus pneumonia(NCP). Methods: 30 patients infected with novel coronavirus referred to jianghan university hospital between January 11, 2020 and January 3, 2020 were studied. […] The data reviewed included those of clinical manifestations, laboratory investigation and Radiographic features. Results: The patients consisted of 10 men and 20 women, including 22 doctors and 8 nurses,aged 21~59 years(mean 35±8 years). […] The average contact times were 12 (7,16) and the average cumulative contact time was 2 (1.5,2.7) h.Clinical symptoms of these patients were fever in 23 patients (76.67%) , headache in 16 petients (53.33%) , fatigue or myalgia in 21patients (70%) , nausea, vomiting or diarrhea in 9 petients (30%) , cough in 25 petients (83.33%) , and dyspnea in 14 petients (46.67%) . | 2020-02-17 |
| 32064853 | Analyses included: 1) summary of patient characteristics; 2) examination of age distributions and sex ratios; 3) calculation of case fatality and mortality rates; 4) geo-temporal analysis of viral spread; 5) epidemiological curve construction; and 6) subgroup analysis. Results: A total of 72 314 patient records-44 672 (61.8%) confirmed cases, 16 186 (22.4%) suspected cases, 10567 (14.6%) clinical diagnosed cases (Hubei only), and 889 asymptomatic cases (1.2%)-contributed data for the analysis. […] The epidemic curve of onset of symptoms peaked in January 23-26, then began to decline leading up to February 11. | 2020-02-17 |
| 32064854 | Residents have a high awareness rate of the main symptoms, transmission routes, using of masks, hand washing and treatment information of NCP, while a low awareness rate of the atypical symptoms. | 2020-02-17 |
| 32064855 | The epidemiological history and clinical characteristics of 7 cases of COVID-19 and 1 case of close contact in the first family aggregation epidemic of COVID-19 in Gansu Province were analyzed. | 2020-02-17 |
| 32065348 | Historical records on prevention and treatment of infections in CM classics, clinical evidence of CM on the prevention of severe acute respiratory syndrome (SARS) and H1N1 influenza, and CM prevention programs issued by health authorities in China since the COVID-19 outbreak were retrieved from different databases and websites till 12 February, 2020. […] Research evidence included data from clinical trials, cohort or other population studies using CM for preventing contagious respiratory virus diseases. | 2020-04-03 |
| 32067043 | We report the epidemiological features of a familial cluster of four patients in Shanghai, of which one was 88 years old man with moving difficulties and was only exposed to his asymptomatic family members who developed symptoms later. | 2020-04-03 |
| 32072569 | This paper aggregates and consolidates the virology, epidemiology, clinical management strategies from both English and Chinese literature, official news channels, and other official government documents. | 2020-04-02 |
| 32072919 | This guideline is applicable to the health protection requirements of large indoor stadiums which are reconstructed as treatment sites for the Novel Coronavirus Pneumonia (NPC) patients with mild symptoms during the outbreak. | 2020-02-19 |
| 32074550 | Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. | 2020-03-18 |
| 32074786 | As surgeons specialized in the treatment of gastrointestinal tumors, we should always be aware of the prevention for NCP and incorporate this awareness into every detail of clinical practice. […] Gastric or esophagogastricjunction (EGJ) malignant tumor with obstruction can be managed with gastric tube decompression or stent placement to relieve the symptoms. | 2020-03-12 |
| 32075364 | Here we analyzed the clinical features, susceptible population, potential causes and therapeutic strategies of NCP related liver injury. | 2020-02-20 |
| 32075786 | To study the clinical characteristics of patients in Zhejiang province, China, infected with the 2019 severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) responsible for coronavirus disease 2019 (covid-2019). […] Clinical data, collected using a standardised case report form, such as temperature, history of exposure, incubation period. […] The most common symptoms at onset of illness were fever in 48 (77%) patients, cough in 50 (81%), expectoration in 35 (56%), headache in 21 (34%), myalgia or fatigue in 32 (52%), diarrhoea in 3 (8%), and haemoptysis in 2 (3%). […] The median time from exposure to onset of illness was 4 days (interquartile range 3-5 days), and from onset of symptoms to first hospital admission was 2 (1-4) days. […] As of early February 2020, compared with patients initially infected with SARS-Cov-2 in Wuhan, the symptoms of patients in Zhejiang province are relatively mild. | 2020-02-28 |
| 32077115 | We aim to investigate the clinical characteristic and allergy status of patients infected with SARS-CoV-2. […] Electronic medical records including demographics, clinical manifestation, comorbidities, laboratory data, and radiological materials of 140 hospitalized COVID-19 patients, with confirmed result of SARS-CoV-2 viral infection, were extracted and analyzed. […] Fever (91.7%), cough (75.0%), fatigue (75.0%), and gastrointestinal symptoms (39.6%) were the most common clinical manifestations, whereas hypertension (30.0%) and diabetes mellitus (12.1%) were the most common comorbidities. […] Detailed clinical investigation of 140 hospitalized COVID-19 cases suggests eosinopenia together with lymphopenia may be a potential indicator for diagnosis. | 2020-02-27 |
| 32077441 | With the spread of COVID-19, the routine clinical diagnosis and treatment for lung cancer patients has been disturbed. […] During the COVID-19 outbreak period, it should be carefully differentiated for fever and respiratory symptoms for lung cancer patients receiving anti-tumor treatment, in order to evaluate the risk of COVID-19. […] Moreover, it is necessary to carry out meticulous and individualized clinical management for lung cancer patients to effectively protect the patients from COVID-19. | 2020-03-16 |
| 32077660 | Objective: To analyze the clinical characteristics of cases of novel coronavirus pneumonia and a preliminary study to explore the relationship between different clinical classification and liver damage. Methods: Consecutively confirmed novel coronavirus infection cases admitted to seven designated hospitals during January 23, 2020 to February 8, 2020 were included. […] Clinical classification (mild, moderate, severe, and critical) was carried out according to the diagnosis and treatment program of novel coronavirus pneumonia (Trial Fifth Edition) issued by the National Health Commission. | 2020-02-20 |
| 32077677 | In this paper, combining with the key clinical problems of prevention and control in hospital during the epidemic period of NCP infection, medical evidence, and clinical and management experience, the author formulates prevention and control management strategy of the author’s unit in order to provide reference for prevention and control of burn and wound care ward. | 2020-02-20 |
| 32077789 | With a longer time after the onset of symptoms, CT findings were more frequent, including consolidation, bilateral and peripheral disease, greater total lung involvement, linear opacities, “crazy-paving” pattern and the “reverse halo” sign. | 2020-02-20 |
| 32078069 | More comprehensive information is required to understand 2019-nCoV feature, the epidemiology of origin and spreading, and the clinical phenomina. | 2020-03-06 |
| 32080991 | With the numbers of confirmed cases are increasing, information on the epidemiologic investigation and clinical manifestation have been accumulated. | 2020-03-16 |
| 32080994 | Complying with overall requirements of the government and regulations on public health emergences, as well as the clinical features of diagnosis and treatment of dental illness, this paper refers to previous guidelines and studies on the infection prevention and control in dental diagnosis and treatment in China and foreign countries. | 2020-02-21 |
| 32081636 | The one case of SARS-CoV-2 pneumonia in the USA is responding well to remdesivir, which is now undergoing a clinical trial in China. | 2020-03-25 |
| 32083328 | The positive selective pressure could account for some clinical features of this virus compared with severe acute respiratory syndrome (SARS) and Bat SARS-like CoV. | 2020-02-28 |
| 32083985 | To date, CT findings have been recommended as major evidence for clinical diagnosis of COVID-19 in Hubei, China. […] This review focuses on the etiology, epidemiology, and clinical symptoms of COVID-19, while highlighting the role of chest CT in prevention and disease control. A full translation of this article in Chinese is available. | 2020-02-21 |
| 32084676 | Although colorectal surgery is not a front-line subject in the fight against the epidemic, but in this special situation, now it is a difficult task that with the premise of how to maximize the protection for patients and their families, health of medical staff, and the safety of wards and hospitals, we can provide the highest quality medical services to ensure the orderly development of previous clinical work. […] Referring to the “Diagnosis and Treatment Scheme for NCP (Trial Version 4 and 5)” and combining the actual practice situation in our hospital with the “Summary of New Coronavirus Files of Shanghai Renji Hospital”, we summarize how to carry out the clinical practice of colorectal surgery under the situation of the prevention and control of the NCP epidemiology, meanwhile under such situation aiming the procedure of diagnose and treatment for emergency patients with colorectal tumor, we share the experiences of the diagnosis of colorectal tumor, the management of patients with colorectal cancer who are scheduled to be admitted for surgery, the protection of wards, the perioperative management. | 2020-02-22 |
| 32086886 | At the same time, this paper analyzes the possible psychological stress symptoms of patients with different oral diseases, and puts forward suggestions for remote consultation and emergency treatment of dentists. | 2020-02-22 |
| 32086938 | Utilizing the Centers for Disease Control and Prevention (CDC, USA) website, and a comprehensive review of PubMed literature, we obtained information regarding clinical signs and symptoms, treatment and diagnosis, transmission methods, protection methods and risk factors for Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS) and COVID-19. | 2020-02-22 |
| 32087621 | In addition, there is up regulation of inflammatory factors in patients with severe NCP, but the effect of renal replacement therapy needs to be further confirmed by clinical research. | 2020-02-23 |
| 32087623 | Objective: To raise awareness about 2019 novel coronavirus pneumonia (NCP) and reduce missed diagnosis rate and misdiagnosis rate by comparing the clinical characteristics between RNA positive and negative patients clinically diagnosed with NCP. Methods: From January 2020 to February 2020, 54 patients who were newly diagnosed with NCP in Wuhan Fourth Hospital were included in this study. […] The patients were divided into RNA positive and negative group, and the differences of clinical, laboratory, and radiological characteristics were compared. Results: There were 31 RNA of 2019-nCov positive cases, and 23 negative cases. […] Common clinical symptoms of two groups were fever (80.64% vs. 86.96%) , chills (61.29% vs.52.17%) , cough (80.64% vs.95.65%) , fatigue (61.30% vs.56.52%) , chest distress (77.42% vs.73.91%) . […] Some other symptoms were headache, myalgia, dyspnea, diarrhea, nausea and vomiting. […] There was no statistically significant difference in other clinical characteristics except for dyspnea between two groups. Conclusions: RNA positive and negative NCP patients shared similar clinical symptoms, while RNA positive NCP patients tended to have dyspnea. | 2020-02-23 |
| 32088679 | The first patients began experiencing symptoms of illness in mid-December 2019. […] Clinical isolates were found to contain a novel coronavirus with similarity to bat coronaviruses. […] There are several critical clinical questions that need to be resolved, including how efficient is human-to-human transmission? | 2020-03-18 |
| 32088847 | We describe the 18F-FDG PET/CT results from four patients who were admitted to the hospital with respiratory symptoms and fever between January 13 and January 20, 2020, when the COVID-19 outbreak was still unrecognized and the virus infectivity was unknown. […] A retrospective review of the patients’ medical history, clinical and laboratory data, as well as imaging findings strongly suggested a diagnosis of COVID-19. […] Although 18F-FDG PET/CT cannot be routinely used in an emergency setting and is generally not recommended for infectious diseases, our pilot data shed light on the potential clinical utility of this imaging technique in the differential diagnosis of complex cases. | 2020-04-03 |
| 32091395 | Breaking down the factors leading to screening successes and failures, we find that most cases missed by screening are fundamentally undetectable, because they have not yet developed symptoms and are unaware they were exposed. | 2020-03-18 |
| 32091414 | The aim of this study was to investigate the chest computed tomography (CT) findings in patients with confirmed coronavirus disease 2019 (COVID-19) and to evaluate its relationship with clinical features. […] The chest CT images and clinical data were reviewed, and the relationship between them was analyzed. […] With regards to the clinical manifestations, 58 (73%) of the 80 patients had cough, and 61 (76%) of the 80 patients had high temperature levels. […] There are significant correlations between the degree of pulmonary inflammation and the main clinical symptoms and laboratory results. | 2020-04-14 |
| 32092748 | This issue has rapidly reviewed and published articles describing COVID-19, including the drug treatment options for SARS-CoV-2, its clinical characteristics, and therapies involving a combination of Chinese and Western medicine, the efficacy of chloroquine phosphate in the treatment of COVID-19 associated pneumonia according to clinical studies, and reflections on the system of reserve medical supplies for public health emergencies. […] As an academic journal, we will continue to quickly and transparently share data with frontline healthcare workers who need to know the epidemiological and clinical features of COVID-19. | 2020-03-18 |
| 32094336 | Preliminarily, those findings have explained the basic mechanism that the oral cavity is a potentially high risk for 2019-nCoV infectious susceptibility and provided a piece of evidence for the future prevention strategy in dental clinical practice as well as daily life. | 2020-03-18 |
| 32096366 | The chest CT images of patients with COVID-19 have certain characteristics with dynamic changes, which are of value for monitoring disease progress and clinical treatment. | 2020-03-16 |
| 32096367 | As the National Clinical Research Center for Infectious Diseases, the First Affiliated Hospital of Zhejiang University School of Medicine is the primary medical care center for COVID-19 inZhejiang Province. […] Based on the present expert consensus carried out by National Health Commission and National Administration of Traditional Chinese Medicine, our team summarized and established an effective treatment strategy centered on “Four-Anti and Two-Balance” for clinical practice. […] The importance of early viralogical detection, dynamic monitoring of inflammatory indexes and chest radiograph was emphasized in clinical decision-making. | 2020-03-16 |
| 32096395 | The characteristics including high contagiousness, herd susceptibility and clinical phenotype diversity, made a serious influence on people’s daily life and rountine therapy for other diseases. […] Breast dieases are clinical common diseases. […] In the central epidemic area of COVID-19, Hubei province, especially Wuhan, the clinical specialists of breast diseases should consider all of the following factors comprehensively: the prevention of COVID-19, the diagnosis and treatment of breast diseases and the accessibility of medical resources. […] Therefore, we carried out some management proposals of the patients with breast diseases in the central epidemic area during the epidemic of COVID-19 on the basis of conventional treatment guidelines and clinical experiences. | 2020-02-25 |
| 32098422 | After the outbreak of the severe acute respiratory syndrome (SARS) in the world in 2003, human coronaviruses (HCoVs) have been reported as pathogens that cause severe symptoms in respiratory tract infections. […] This virus causes acute lung symptoms, leading to a condition that has been named as “coronavirus disease 2019” (COVID-19). […] There are some similarities and differences in the epidemiology and clinical features between these two viruses and diseases that are caused by these viruses. | 2020-03-23 |
| 32099934 | Due to significant variations in the control strategies, which have been changing over time, and thanks to the introduction of detection technologies that have been rapidly improved, enabling to shorten the time from infection/symptoms onset to diagnosis, leading to faster confirmation of the new coronavirus cases, our previous estimations on the transmission risk of the 2019-nCoV need to be revised. | 2020-04-01 |
| 32100486 | In this study, we present serial CT findings in a 40-year-old female patient with COVID-19 pneumonia who presented with the symptoms of fever, chest tightness, and fatigue. | 2020-03-24 |
| 32100976 | Noninvasive or invasive positive pressure ventilation will be important means for those patients, which will help to improve the clinical cure rate and reduce the mortality. | 2020-02-26 |
| 32100980 | Clinicians should make individual clinical decisions based on the specifics of each patient durding epidemic situation. | 2020-02-26 |
| 32102625 | The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. […] Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. | 2020-03-19 |
| 32102726 | Most of the infected patients have mild symptoms including fever, fatigue and cough. | 2020-02-27 |
| 32104915 | This virus shares highly homological sequence with SARS-CoV, and causes acute, highly lethal pneumonia coronavirus disease 2019 (COVID-19) with clinical symptoms similar to those reported for SARS-CoV and MERS-CoV. | 2020-03-18 |
| 32104917 | With this test kit, we carried out clinical studies to validate its clinical efficacy uses. […] The clinical detection sensitivity and specificity of this test were measured using blood samples collected from 397 PCR confirmed COVID-19 patients and 128 negative patients at eight different clinical sites. […] In addition, we evaluated clinical diagnosis results obtained from different types of venous and fingerstick blood samples. | 2020-04-13 |
| 32105090 | As the world is witnessing the epidemic of COVID-19, a disease caused by a novel coronavirus, SARS-CoV-2, emerging genetics and clinical evidences suggest a similar path to those of SARS and MERS. | 2020-03-24 |
| 32105632 | We aimed to describe the clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia. […] Demographic data, symptoms, laboratory values, comorbidities, treatments, and clinical outcomes were all collected. | 2020-04-01 |
| 32105637 | Patients were grouped on the basis of the interval between symptom onset and the first CT scan: group 1 (subclinical patients; scans done before symptom onset), group 2 (scans done ≤1 week after symptom onset), group 3 (>1 week to 2 weeks), and group 4 (>2 weeks to 3 weeks). […] Combining assessment of imaging features with clinical and laboratory findings could facilitate early diagnosis of COVID-19 pneumonia. | 2020-04-08 |
| 32105680 | In 2 reports describing 18 pregnancies with coronavirus disease 2019, all were infected in the third trimester, and clinical findings were similar to those in nonpregnant adults. | 2020-04-15 |
| 32107577 | We aimed to report the imaging and clinical characteristics of these patients infected with SARS-CoV-2 in Guangzhou, China. […] We analyzed the clinical characteristics of the patients, as well as the distribution characteristics, pattern, morphology, and accompanying manifestations of lung lesions. […] SARS-CoV-2 infection can be confirmed based on the patient’s history, clinical manifestations, imaging characteristics, and laboratory tests. | 2020-04-03 |
| 32107909 | Objective: To explorethe proper protective measures for pancreaticdiseases treatment during theoutbreak of 2019 coronavirus disease(COVID-19). Method: Clinical data of four cases of patients that suffered COVID-19from February 2(nd), 2020 to February 9(th), 2020 in pancreatic surgery were reviewed.After the first patientscuffednosocomial infection of COVID-19, the general protective measures in our department wereupdated.Only one patient was admitted to each room alone, with no more than one caregiver.The body temperature of care givers was measuredtwice a day.Primary protections were applied to all staff.The floor was sterilized using disinfectant with an effective chlorine concentration of 1000 mg/L.The protective measures for interventional procedures were as follow.Primary protection was applied to the operators ofcentral venipuncture catheter, percutaneous abdominal/pleural drainage, percutaneous retroperitoneal drainage, percutaneous transhepatic cholangial drainage and other surgical procedures with local anesthesiaand epidural anesthesia.Secondary protection was applied to the operators of endoscopic retrograde cholangiopancreatography and surgical procedures with general anesthesia. Results: During Feb 2(nd), 2020 to Feb 9(th), 2020, four patients in our department were diagnosed with COVID-19, of which one was died of COVID-19, two were cured, and one is still in hospital for COVID-19. | 2020-02-28 |
| 32108351 | We aim to summarize reliable evidence of evidence-based medicine for the treatment and prevention of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by analyzing all the published studies on the clinical characteristics of patients with SARS-CoV-2. […] Several studies on the clinical characteristics of SARS-CoV-2 infection were collected for meta-analysis. […] Fever and cough are the most common symptoms in patients with SARS-CoV-2 infection, and most of these patients have abnormal chest CT examination. […] Diarrhea, hemoptysis, headache, sore throat, shock, and other symptoms are rare. | 2020-03-18 |
| 32108352 | With more and more patients diagnosed, China has carried out more than 100 clinical studies of new coronavirus infection, including antiviral drugs, antimalarial drugs, glucocorticoids, plasma therapy, virus vaccine, and other Western drugs, while Chinese medicine research accounted for half of the studies. […] Compared with that of during SARS period in 2003, China has the stronger capability to carry out clinical trials of new drugs in emergency period. | 2020-03-05 |
| 32109013 | Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, data have been needed on the clinical characteristics of the affected patients. […] The most common symptoms were fever (43.8% on admission and 88.7% during hospitalization) and cough (67.8%). | 2020-04-07 |
| 32109279 | We aimed to report the clinical characteristics of imported coronavirus disease-19 (COVID-19) in Jiangsu Province. […] We retrospectively investigated the clinical, imaging, and laboratory characteristics of confirmed cases of COVID-19 with WHO interim guidance in three Grade ⅢA hospitals of Jiangsu from Jan 22 to Feb 14, 2020. […] Except for 3 severe patients, the rest of the 77 patients exhibited mild or moderate symptoms. 9 patients were unconfirmed until a third-time nucleic acid test. 38 cases had a history of chronic diseases. […] The main clinical manifestations of the patients were fever and cough, which accounted for 63 cases (78.75%) and 51 cases (-63.75%) respectively. […] Compared with the cases in Wuhan, the cases in Jiangsu exhibited mild or moderate symptoms and no obvious gender susceptivity. | 2020-04-03 |
| 32109443 | To investigate the clinical and imaging characteristics of computed tomography (CT) in novel coronavirus pneumonia (NCP) caused by SARS-CoV-2. […] The clinical and imaging data were analyzed. | 2020-04-06 |
| 32109444 | Therefore, it is critical to understand the nature of the virus and its clinical characteristics, in order to respond to the 2019-nCoV outbreak. | 2020-04-06 |
| 32110875 | Some are being tested in clinical trials against MERS-CoV and SARS-CoV, while others have been listed for clinical trials against 2019-nCoV. | 2020-04-11 |
| 32111449 | The reported cases highlight non-specific clinical presentations of 2019 novel coronavirus disease (COVID-19) as well as the importance of rapid laboratory-based diagnosis. | 2020-04-01 |
| 32112549 | Combining the guidelines for diagnosis and treatment of tumors with our clinical experience, in this epidemic period, we discuss the strategies for diagnosis, treatment, and follow-up of malignant tumors of the digestive system in this article. | 2020-02-29 |
| 32112714 | Most reviewed studies reported negative psychological effects including post-traumatic stress symptoms, confusion, and anger. | 2020-03-26 |
| 32112884 | The aim of this paper was to describe the clinical characteristics and imaging manifestations of hospitalized patients with confirmed COVID-19 infection in Wenzhou, Zhejiang, China. […] Fever, cough and expectoration were the most common symptoms, 14 patients had decreased oxygen saturation, 33 had leukopenia, 53 had lymphopenia, and 82 had elevated C-reactive protein. | 2020-04-06 |
| 32112886 | We analyzed the data of 262 confirmed cases to determine the clinical and epidemiological characteristics of COVID-19 in Beijing. […] The information on demographic, epidemiological, clinical, laboratory test for the COVID-19 virus, diagnostic classification, cluster case and outcome were obtained. […] The most common symptoms at the onset of illness were fever (82.1%), cough (45.8%), fatigue (26.3%), dyspnea (6.9%) and headache (6.5%). | 2020-04-06 |
| 32113198 | Regardless of the cases diagnosed by clinical examines, the numbers of daily emerging cases of China (Hubei province not included), Hubei Province (Wuhan city not included) and Wuhan city reached the peak in the early February. | 2020-03-01 |
| 32113704 | In this review, we highlights the symptoms, epidemiology, transmission, pathogenesis, phylogenetic analysis and future directions to control the spread of this fatal disease. | 2020-04-15 |
| 32114094 | Because both patients did not exhibit symptoms of pneumonia at the time of operation, these changes likely represent an early phase of the lung pathology of COVID-19 pneumonia. | 2020-04-09 |
| 32114193 | Here we report the epidemiological, clinical, laboratory and radiological characteristics of 19 suspect cases. | 2020-04-13 |
| 32114744 | Objective: To investigate the clinical characteristics and placental pathology of 2019-nCoV infection in pregnancy, and to evaluate intrauterine vertical transmission potential of 2019-nCoV infection. Methods: The placentas delivered from pregnant women with confirmed 2019-nCoV infection which were received in the Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology collected by February 4th, 2020 and retrospectively studied. […] Their clinical material including placental tissue and lung CT, and laboratory results were collected, meanwhile, nucleic acid detection of 2019-nCoV of the placentas were performed by RT-PCR. Results: Three placentas delivered from pregnant women with confirmed 2019-nCoV infection, who were all in their third trimester with emergency caesarean section. […] All samples from three placentas were negative for the nucleic acid of 2019-nCoV. Conclusions: The clinical characteristics of pregnant women with 2019-nCoV infection in late pregnancy are similar to those of non-pregnant patients, and no severe adverse pregnancy outcome is found in the 3 cases of our observation. | 2020-03-02 |
| 32114755 | Controversy remains over whether the novel coronavirus 2019 (COVID-19) virus may have infectivity during the incubation period before the onset of symptoms. | 2020-04-14 |
| 32117569 | The sequence of the ACE2-Fc protein is provided to investigators, allowing its possible use in recombinant protein expression systems to start producing drug today to treat patients under compassionate use, while formal clinical trials are later undertaken. | 2020-03-20 |
| 32118389 | Objective: To analyze the epidemiological history, clinical manifestations, treatment and the short-term prognosis of 31 cases of 2019 novel coronavirus(2019-nCoV) infection in children from six provinces (autonomous region) in northern China. Methods: A retrospective analysis of the epidemiological history, clinical symptoms, signs, laboratory examinations, chest imaging, treatment and the short-term prognosis of 31 cases of 2019-nCoV was conducted. […] The clinical types were asymptomatic type in 4 cases (13%), mild type in 13 cases (42%), and common type in 14 cases (45%). […] Other symptoms included cough (n=14, 45%), fatigue (n=3, 10%) and diarrhea (n=3, 9%). […] Clinical types are asymptomatic, mild and common types. […] Clinical manifestations and laboratory examination results are nonspecific. | 2020-03-02 |
| 32118390 | Among 605 patients, the symptoms were fever (553 cases, 91.4%) , debilitation (44 cases, 7.3%) , cough (110 cases, 18.2%) , expectoration (19 cases, 3.1%) , chills (6 cases, 1.0%) , shiver (7 cases, 1.2%) , running nose (21 cases, 3.5%) , stuffy noses (8 cases, 1.3%) , throat dryness and sore (24 cases, 4.0%) , headache (21 cases, 3.5%) , chest pain (6 cases, 1.0%) , anhelation (18 cases, 3.0%) , and gastrointestinal symptom (21 cases, 3.5%) . | 2020-03-02 |
| 32118391 | This might be due to the biological characteristics of 2019-nCoV, and might also be related to the basic disease, clinical status, glucocorticoid using, sample sampling, processing and detecting of patients, and some even related to the re-infection or secondary bacterial virus infection. | 2020-03-02 |
| 32118394 | Lung cancer patients are difficult to differentiate from patients with COVID-19 in terms of clinical symptoms, which will bring great trouble to the clinical work and physical and mental health of lung cancer patients. | 2020-03-02 |
| 32118533 | We describe 2 cases of COVID-19 in patients with mild upper respiratory symptoms. […] One patient had persistent, low-grade upper respiratory tract symptoms without fever. | 2020-03-02 |
| 32118615 | To investigate the clinical and CT features associated with severe and critical Corona Virus Disease 2019 (COVID-19) pneumonia. […] The chest CT images and clinical data of them were reviewed and compared. […] The clinical factors of age > 50 years old, comorbidities, dyspnea, chest pain, cough, expectoration, decreased lymphocytes and increased inflammation indicators were risk factors for severe/critical COVID-19 pneumonia. […] There are significant differences in clinical symptoms, laboratory examinations and CT manifestations between the ordinary patients and the severe/critical patients. | 2020-03-02 |
| 32118639 | The clinical data and laboratory test results of convalescent patients with COVID-19 who were admitted to from January 20, 2020 to February 10, 2020 were collected retrospectively. […] Convalescent patients refer to recovered non-febrile patients without respiratory symptoms who had two successive (minimum 24 h sampling interval) negative RT-PCR results for viral RNA from oropharyngeal swabs. […] After in-hospital treatment, patients’ inflammatory indicators decreased with improved clinical condition. […] The median time from the onset of symptoms to first negative RT-PCR results for oropharyngeal swabs in convalescent patients was 9.5 (6.0-11.0) days. | 2020-03-02 |
| 32118640 | Individual data, laboratory indices, imaging characteristics, and clinical data were collected, and statistical analysis was performed. […] Based on clinical typing results, the patients were divided into a progression group or an improvement/stabilization group. | 2020-03-02 |
| 32119825 | We considered scenarios that varied in the number of initial cases, the basic reproduction number (R0), the delay from symptom onset to isolation, the probability that contacts were traced, the proportion of transmission that occurred before symptom onset, and the proportion of subclinical infections. […] The probability of control decreases with long delays from symptom onset to isolation, fewer cases ascertained by contact tracing, and increasing transmission before symptoms. | 2020-03-26 |
| 32120312 | The purpose of this case report is to describe the imaging and associated clinical features of an asymptomatic novel coronavirus pneumonia (COVID-19) patient outside Wuhan, China. […] The principle findings are that in this patient with laboratory-confirmed COVID-19, CT findings preceded symptoms and included bilateral pleural effusions, previously not reported in association with COVID-19. | 2020-04-09 |
| 32120458 | Objective: To explore the clinical characteristics and prognosis of the new coronavirus 2019-nCoV patients combined with cardiovascular disease (CVD). Methods: A retrospective analysis was performed on 112 COVID-19 patients with CVD admitted to the western district of Union Hospital in Wuhan, from January 20, 2020 to February 15, 2020. […] They were divided into critical group (ICU, n=16) and general group (n=96) according to the severity of the disease and patients were followed up to the clinical endpoint. | 2020-03-02 |
| 32124000 | In order to minimise cross-infection of COVID-19, a triage system was set up to identify patients with fever, respiratory symptoms, acute conjunctivitis or recent travel to outbreak areas and to encourage these individuals to postpone their appointments for at least 14 days. […] All elective clinical services were suspended. […] Infection control training was provided to all clinical staff. […] All staff were advised to measure their own body temperatures before work and promptly report any symptoms of upper respiratory tract infection, vomiting or diarrhoea. […] In order to minimise transmission of COVID-19, ophthalmologists should work closely with local infection control teams to implement infection control measures that are appropriate for their own clinical settings. | 2020-03-03 |
| 32124995 | And we found that patients with a positive stool test did not experience gastrointestinal symptoms and had nothing to do with the severity of the lung infection. […] These results may help to understand the clinical diagnosis and the changes in clinical parameters of COVID-19. | 2020-03-12 |
| 32125127 | COVID-19 is a highly infectious respiratory infection disease, which leads to dysfunction of respiratory, physical, and psychological of the patients. pulmonary rehabilitation is an important intervention for clinical patients as well as cure patients. […] With the deeper cognition of COVID-19 and accumulation of clinical experience, we proposed the recommendations for pulmonary rehabilitation of COVID-19 in adults based on the opinions of front-line clinical experts involved in the management of this epidemic and a review of the relevant literature and evidences: 1. for the inpatients with COVID-19, pulmonary rehabilitation would relieve the symptoms of dyspnea, anxiety, and depression; eventually improve physical function and the quality of life; 2. […] These recommendations can serve as a clinical practice guidence and basis for pulmonary rehabilitation of COVID-19. | 2020-03-03 |
| 32125129 | This puts a lot of pressure on clinical resources and care. […] These put a lot of pressure on clinical resources and care. | 2020-03-03 |
| 32125132 | During epidemic of COVID-19, a guideline for the optimal management of patients with advanced lung cancer urgently needs to be proposed to distinguish the symptoms of COVID-19 and the side effects of antitumor drugs. […] This network questionnaire survey was conducted on the lung cancer group of the Chinese Thoracic Society, Chinese Medical Association; the lung cancer group of the Chinese Society of Clinical Oncology Youth Committee; and the Chinese Respiratory Oncology Collaboration. 321 valid questionnaires were received. […] During the epidemic of COVID-19, We recommended that patients with advanced NSCLC should be treated as outpatients as possible at the nearest medical center; Patients who need to be hospitalized for antitumor treatment should be excluded from COVID-19 infection; More intensive attention should be paid to identification of COVID-19-related symptoms and adverse reactions caused by the malignancy or antitumor treatments. | 2020-03-03 |
| 32125140 | In this brief review, we summarize the broad antiviral activity of niclosamide and highlight its potential clinical use in the treatment of COVID-19. | 2020-04-09 |
| 32125362 | To report the initial experience in Singapore with the epidemiologic investigation of this outbreak, clinical features, and management. […] Clinical, laboratory, and radiologic data were collected, including PCR cycle threshold values from nasopharyngeal swabs and viral shedding in blood, urine, and stool. […] Clinical course was summarized, including requirement for supplemental oxygen and intensive care and use of empirical treatment with lopinavir-ritonavir. […] Among the 18 hospitalized patients with PCR-confirmed SARS-CoV-2 infection (median age, 47 years; 9 [50%] women), clinical presentation was an upper respiratory tract infection in 12 (67%), and viral shedding from the nasopharynx was prolonged for 7 days or longer among 15 (83%). […] Among the first 18 patients diagnosed with SARS-CoV-2 infection in Singapore, clinical presentation was frequently a mild respiratory tract infection. […] Some patients required supplemental oxygen and had variable clinical outcomes following treatment with an antiretroviral agent. | 2020-03-17 |
| 32125642 | In the absence of a proven clinical FcR blocker, the use of intravenous immunoglobulin to block FcR activation may be a viable option for the urgent treatment of pulmonary inflammation to prevent severe lung injury. | 2020-03-03 |
| 32125873 | The purpose of this study was to investigate the relation between chest CT findings and the clinical conditions of COVID-19 pneumonia. MATERIALS AND METHODS. Data on 101 cases of COVID-19 pneumonia were retrospectively collected from four institutions in Hunan, China. […] Basic clinical characteristics and detailed imaging features were evaluated and compared between two groups on the basis of clinical status: nonemergency (mild or common disease) and emergency (severe or fatal disease). RESULTS. Patients 21-50 years old accounted for most (70.2%) of the cohort, and five (5.0%) patients had disease associated with a family outbreak. | 2020-03-04 |
| 32127123 | Since the symptoms are similar to other respiratory infections, differential diagnosis in travellers arriving from countries with wide-spread COVID-19 must include other more common infections such as influenza and other respiratory tract diseases. | 2020-03-18 |
| 32129518 | This commentary elaborates on the idea of considering AT1R blockers as tentative treatment for SARS-CoV-2 infections, and proposes a research direction based on datamining of clinical patient records for assessing its feasibility. | 2020-03-04 |
| 32129583 | Objective: To identify the characteristics including clinical features and pulmonary computed tomography (CT) features of heart failure and novel coronavirus pneumonia(COVID-19). Methods: This study was a retrospective study. […] The baseline clinical and imaging features of the two groups were statistically analyzed. Results: There was no significant difference in age and sex between the two groups, but the incidence of epidemiological contact history, fever or respiratory symptoms in the COVID-19 group was significantly higher than that in the heart failure group (12/12 vs. 2/7, P=0.001; 12/12 vs. 4/7, P<0.001). […] 2/7, P=0.048) . Conclusions: More patients with COVID-19 have epidemiological history and fever or respiratory symptoms. | 2020-03-04 |
| 32129843 | Although how the intra-host variant spreads in the population is still elusive, it is necessary to strengthen the surveillance of the viral evolution in the population and associated clinical changes. | 2020-04-03 |
| 32130038 | We reviewed the clinical information, CT images, and corresponding image reports of these 53 patients. | 2020-03-04 |
| 32131151 | Objective: To investigate the mental health of clinical first-line medical staff in COVID-19 epidemic and provide theoretical basis for psychological intervention. Method: The mental health status of the first-line medical staff was investigated by Self-rating Anxiety Acale (SAS) and Post-Traumatic Stress Disorder Self-rating Scale(PTSD-SS). | 2020-03-04 |
| 32132196 | The COVID-19-RdRp/Hel assay did not cross-react with other human-pathogenic coronaviruses and respiratory pathogens in cell culture and clinical specimens, whereas the RdRp-P2 assay cross-reacted with SARS-CoV in cell culture. | 2020-04-01 |
| 32133578 | Previous studies have reported epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19). […] The purpose of this brief review is to summarize those published studies as of late February 2020 on the clinical features, symptoms, complications, and treatments of COVID-19 and help provide guidance for frontline medical staff in the clinical management of this outbreak. | 2020-03-05 |
| 32133829 | The detection of oropharyngeal swab virus nucleic acid were negative in all 9 healthcare workers, none of them had fever or any respiratory symptoms. | 2020-03-05 |
| 32133830 | Objective: To describe the epidemiological characteristics of a cluster of COVID-19 cases reported in Baodi district of Tianjin as of 18 February, 2020, which might be associated with the exposure in a local department store, and provide suggestions for prevention and control strategy development. Methods: The basic characteristics, time and area distributions, clinical manifestations, epidemiological history and transmission mode of the COVID-19 cases associated with the department store exposure were analyzed. Results: A total of 40 COVID-19 cases were associated with the department store exposure, accounting for 75.47% of the total confirmed cases (53 cases) reported in Baodi district. […] The main clinical manifestations included fever (95.00%), cough (35.00%), and diarrhea (15.00%). | 2020-03-05 |
| 32133833 | Information of clinical manifestations, history of epidemiology, lab tests and chest CT scan images of visiting patients from February 13 to February 28 were collected. […] This patient denied any contact with confirmed/suspected cases of 2019-nCoV infection and without fever and other respiratory symptoms. […] Considering the negative result of nuclear acid testing, this patient was presumptively diagnosed as viral pneumonia and an experiential anti-infection treatment had been prescribed for him. Conclusions: The 2019 novel coronavirus disease (COVID-19) complicates the clinical scenario of pulmonary infiltrates in cancer patients. […] The epidemic history, clinical manifestation, CT scan image and lab test should be combined consideration. | 2020-03-05 |
| 32134116 | Limited epidemiological and clinical data suggest that the disease spectrum of COVID-19 may differ from SARS or MERS. […] We summarize latest literatures on genetic, epidemiological, and clinical features of COVID-19 in comparison to SARS and MERS and emphasize special measures on diagnosis and potential interventions. | 2020-03-31 |
| 32134205 | To discuss the different characteristics of clinical, laboratory, and chest computed tomography (CT) in pediatric patients from adults with 2019 novel coronavirus (COVID-19) infection. […] The clinical, laboratory, and chest CT features of 20 pediatric inpatients with COVID-19 infection confirmed by pharyngeal swab COVID-19 nucleic acid test were retrospectively analyzed during 23 January and 8 February 2020. […] The clinical and laboratory information was obtained from inpatient records. […] Fever (12/20, 60%) and cough (13/20, 65%) were the most common symptoms. | 2020-04-16 |
| 32134278 | Several clinical, genetic and epidemiological features of COVID-19 resemble SARS-CoV infection. | 2020-03-24 |
| 32134681 | CT images and clinical data were reviewed. […] Compared with early-phase disease (≤ 7 days after the onset of symptoms), advanced-phase disease (8-14 days after the onset of symptoms) was characterized by significantly increased frequencies of GGO plus a reticular pattern, vacuolar sign, fibrotic streaks, a subpleural line, a subpleural transparent line, air bronchogram, bronchus distortion, and pleural effusion; however, GGO significantly decreased in advanced-phase disease. CONCLUSION. CT examination of patients with COVID-19 pneumonia showed a mixed and diverse pattern with both lung parenchyma and the interstitium involved. | 2020-03-05 |
| 32134800 | We aimed to quantify severity of COVID-19 infection on High-Resolution CT and to determine its relationship with clinical parameters. […] From Jan 11, 2020, to Feb 5, 2020, the clinical, laboratory and HRCT features of 42 patients (26-75 years, 25 males) with COVID-19 were analyzed. […] Correlations among clinical parameters, initial CT features and progression of opacifications were evaluated with Spearman correlation and linear regression analysis. […] Patients with the COVID-19 infection usually presented with typical ground-grass opacities and other CT features, which showed significant correlations with some clinical and laboratory measurements. | 2020-03-06 |
| 32134861 | To promptly identify patients and prevent further spreading, physicians should be aware of the travel or contact history of the patient with compatible symptoms. | 2020-03-18 |
| 32138488 | There is a spectrum of clinical features from mild to severe life threatening disease with major complications like severe pneumonia, ARDS, acute cardiac injury and septic shock. […] Presence of bilateral ground glass opacity and consolidation on imaging in appropriate clinical background should raise a suspicion about COVID 19. | 2020-03-10 |
| 32139372 | This article will review the new knowledge of SARS-CoV-2 COVID-19 acute respiratory disease, and summarise its clinical features. | 2020-03-23 |
| 32141279 | However, such sources of infection cannot be effectively identified due to the symptoms absent. | 2020-03-06 |
| 32141280 | The past medical history of CHD and increased level of cTnI are two independent determinants of clinical disease status in patients with COVID-19. 目的： 分析新型冠状病毒肺炎（COVID-19）危重症患者心肌损伤及患有心血管基础疾病的情况。 | 2020-03-06 |
| 32141569 | COVID-19 is similar to Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) virus in its pathogenicity, clinical spectrum, and epidemiology. […] COVID-19 causes COVID-19 disease that has similar symptoms as SARS-CoV. | 2020-03-18 |
| 32141570 | This study aimed at investigating the global prevalence, biological and clinical characteristics of novel coronavirus, Wuhan China (2019-nCoV), Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection outbreaks. […] We also recorded the information from research documents published in global scientific journals indexed in ISI Web of Science and research centers on the prevalence, biological and clinical characteristics of 2019-nCoV, SARS-CoV, and MERS-CoV. […] The major clinical manifestations in coronavirus infections 2019-nCoV, MERS-CoV, and SARS CoV are fever, chills, cough, shortness of breath, generalized myalgia, malaise, drowsy, diarrhea, confusion, dyspnea, and pneumonia. | 2020-03-18 |
| 32142651 | A TMPRSS2 inhibitor approved for clinical use blocked entry and might constitute a treatment option. | 2020-04-01 |
| 32143990 | While human strains of Coronavirus are associated with about 15% of cases of the common cold, the SARS-CoV-2 may present with varying degrees of severity, from flu-like symptoms to death. | 2020-04-15 |
| 32144890 | This minireview summarizes the research literature on the virological, clinical and epidemiological aspects of this epidemic published until end of February 2020. | 2020-04-08 |
| 32145185 | This Seminar provides an update on the current knowledge and perspectives on MERS epidemiology, virology, mode of transmission, pathogenesis, diagnosis, clinical features, management, infection control, development of new therapeutics and vaccines, and highlights unanswered questions and priorities for research, improved management, and prevention. | 2020-04-13 |
| 32145716 | Whatever happens, screening and isolating close contacts remains essential except for clinical treatment during the epidemic. | 2020-03-08 |
| 32145718 | Since then, although scholars have appealed to incorporating public health and clinical medicine education, and breaking down separations between public health and clinical workforce in China, the effect is yet not so obvious. […] Consequently, the Chinese people have higher expectations on the modernization of public health governance, and the social atmosphere of incorporating preventive medicine and clinical medical education is establishing. […] In future, when combating with novel infectious diseases and public health emergencies, the response capacity of public health system and treatment capacity of clinical system will be significantly improved, while the situation on insufficient integration of prevention and treatment is bound to be reversed. | 2020-03-08 |
| 32145719 | Few days ago, we conducted a study on the epidemiological and clinical characteristics of asymptomatic infections of COVID-19, and found them might be the infection source. | 2020-03-08 |
| 32145768 | COVID-19 differs from SARS in terms of infectious period, transmissibility, clinical severity, and extent of community spread. | 2020-04-01 |
| 32146694 | Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease (COVID-19) and the evidence of person-to-person transmission. […] This study aims to present the clinical characteristics of 24 cases with asymptomatic infection screened from close contacts and to show the transmission potential of asymptomatic COVID-19 virus carriers. […] Their clinical records, laboratory assessments, and chest CT scans were reviewed. […] As a result, none of the 24 asymptomatic cases presented any obvious symptoms while nucleic acid screening. […] Five cases (20.8%) developed symptoms (fever, cough, fatigue, etc.) during hospitalization. […] The remaining 7 (29.2%) cases showed normal CT image and had no symptoms during hospitalization. | 2020-03-08 |
| 32147628 | Several drugs such as chloroquine, arbidol, remdesivir, and favipiravir are currently undergoing clinical studies to test their efficacy and safety in the treatment of coronavirus disease 2019 (COVID-19) in China; some promising results have been achieved thus far. | 2020-03-16 |
| 32149037 | The epidemiological and clinical characteristics of all 28 cases were analyzed in response to this disease. […] The epidemiological characteristics and early clinical features of the 28 patients from Korea with confirmed COVID-19 were analyzed using COVID-19 reporting and surveillance data and the epidemiological investigation reports prepared by the rapid response team. […] The early symptoms were fever, sore throat, cough or sputum production, chills, and muscle ache. […] The initial symptoms were mostly minor, but the disease was infectious at this stage, resulting from close contact, particularly at home. | 2020-03-20 |
| 32149484 | Besides respiratory symptoms, there were also gastrointestinal symptoms, of which diarrhea was the most common one. Conclusion: Family clustering had been an important part for COVID-19 cases. 目的： 通过对1起家庭聚集性新型冠状病毒肺炎8例病例的流行病学调查分析，探讨流行病学特征，为新型冠状病毒肺炎的防控提供依据。 | 2020-03-09 |
| 32149769 | Our results strongly suggest that CEP is a wide-spectrum inhibitor of pan-betacoronavirus, and clinical trial of CEP for treatment of 2019-nCoV infection is warranted. | 2020-03-09 |
| 32149773 | Patients who become infected with 2019-nCoV may initially develop mild upper respiratory tract symptoms. […] We will use the clinical improvement rate as our primary endpoint. […] Secondary endpoints include the timing of clinical improvement after intervention, duration of mechanical ventilation, duration of hospitalization, overall incidence of adverse events, as well as rate of adverse events at each visit, and mortality at 2 and 4 weeks. […] Oral and parenteral glucocorticoids have been used in the management of severe respiratory symptoms in coronavirus-infected patients in the past. | 2020-03-09 |
| 32150748 | There is limited support for many of its key epidemiologic features, including the incubation period for clinical disease (coronavirus disease 2019 [COVID-19]), which has important implications for surveillance and control activities. […] The median incubation period was estimated to be 5.1 days (95% CI, 4.5 to 5.8 days), and 97.5% of those who develop symptoms will do so within 11.5 days (CI, 8.2 to 15.6 days) of infection. […] These estimates imply that, under conservative assumptions, 101 out of every 10 000 cases (99th percentile, 482) will develop symptoms after 14 days of active monitoring or quarantine. | 2020-03-22 |
| 32151335 | This study aimed to evaluate the clinical characteristics of COVID-19 in pregnancy and the intrauterine vertical transmission potential of COVID-19 infection. […] Clinical records, laboratory results, and chest CT scans were retrospectively reviewed for nine pregnant women with laboratory-confirmed COVID-19 pneumonia (ie, with maternal throat swab samples that were positive for severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) who were admitted to Zhongnan Hospital of Wuhan University, Wuhan, China, from Jan 20 to Jan 31, 2020. […] Other symptoms, including cough (in four of nine patients), myalgia (in three), sore throat (in two), and malaise (in two), were also observed. […] The clinical characteristics of COVID-19 pneumonia in pregnant women were similar to those reported for non-pregnant adult patients who developed COVID-19 pneumonia. | 2020-03-18 |
| 32152082 | The most promising compound is remdesivir (GS-5734), a nucleotide analog prodrug currently in clinical trials for treating Ebola virus infections. […] LPV/RTV-INFb also improved clinical parameters in marmosets and mice infected with MERS-CoV. | 2020-03-10 |
| 32153167 | Patients with novel coronavirus pneumonia usually had history of travelling or living in the epidemic area including Wuhan within 14 days before onset, or have been exposed to patients who had fever or respiratory symptoms from the epidemic area, or had clustering diseases. […] In this article, the clinical and chest imaging features of the novel coronavirus pneumonia were reviewed and compared with other infections and non-infectious diffuse pulmonary diseases. | 2020-03-10 |
| 32153170 | Objective: To understand the clinical characteristics, change of liver function, influencing factors and prognosis in hospitalized patients with coronavirus disease-19 (COVID-19) combined with liver injury. Methods: The general conditions, biochemical indicators of liver, blood clotting mechanism, routine blood test, UGT1A1 * 28 gene polymorphism and other data of 40 cases with COVID-19 admitted to the isolation ward of Tangdu Hospital were retrospectively analyzed. […] The clinical characteristics, influencing factors and prognosis of liver injury in patients with liver injury group and those with normal liver function group were compared. | 2020-03-10 |
| 32154135 | However, the clinical features of these cases have not been reported, and there is no sufficient evidence for the proper prevention and control of 2019-nCoV infections in neonates. […] The clinical features and outcomes of 10 neonates (including 2 twins) born to 9 mothers with confirmed 2019-nCoV infection in 5 hospitals from January 20 to February 5, 2020 were retrospectively analyzed. […] Among these 9 pregnant women with confirmed 2019-nCoV infection, onset of clinical symptoms occurred before delivery in 4 cases, on the day of delivery in 2 cases, and after delivery in 3 cases. […] In most cases, fever and a cough were the first symptoms experienced, and 1 patient also had diarrhea. […] Clinically, the first symptom in the neonates was shortness of breath (n=6), but other initial symptoms such as fever (n=2), thrombocytopenia accompanied by abnormal liver function (n=2), rapid heart rate (n=1), vomiting (n=1), and pneumothorax (n=1) were observed. | 2020-03-13 |
| 32155789 | Research data are needed to develop evidence-driven strategies to reduce adverse psychological impacts and psychiatric symptoms during the epidemic. […] The online survey collected information on demographic data, physical symptoms in the past 14 days, contact history with COVID-19, knowledge and concerns about COVID-19, precautionary measures against COVID-19, and additional information required with respect to COVID-19. […] In total, 53.8% of respondents rated the psychological impact of the outbreak as moderate or severe; 16.5% reported moderate to severe depressive symptoms; 28.8% reported moderate to severe anxiety symptoms; and 8.1% reported moderate to severe stress levels. […] Female gender, student status, specific physical symptoms (e.g., myalgia, dizziness, coryza), and poor self-rated health status were significantly associated with a greater psychological impact of the outbreak and higher levels of stress, anxiety, and depression (p < 0.05). | 2020-03-18 |
| 32156101 | More critically, there have been reports about the possibility of this virus to transmit even before a virus-carrying person to show symptoms. | 2020-03-11 |
| 32156329 | We observed good analytical performance in clinical specimens. | 2020-03-17 |
| 32156607 | The RT-PCR detection of viral nucleic acid test (NAT) was one of the most quickly established laboratory diagnosis method in a novel viral pandemic, just as in this COVID-19 outbreak. 4880 cases that had respiratory infection symptoms or close contact with COVID-19 patients in hospital in Wuhan, China, were tested for SARS-CoV-2 infection by use of quantitative RT-PCR (qRT-PCR) on samples from the respiratory tract. | 2020-04-14 |
| 32156648 | Following the public-health emergency of international concern (PHEIC) declared by the World Health Organization (WHO) on 30 January 2020 and the recent outbreak caused by 2019 novel coronavirus (2019-nCoV) [officially renamed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] in China and 29 other countries, we aimed to summarise the clinical aspects of the novelBetacoronavirus disease (COVID-19) and its possible clinical presentations together with suggested therapeutic algorithms for patients who may require antimicrobial treatment. | 2020-04-06 |
| 32157264 | KRD regimen, in our clinical case, showed some activity being well tolerated in a very poor prognosis disease such as PCL. | 2020-03-12 |
| 32157732 | More than 100 therapeutic monoclonal antibodies (mAbs) are approved or in late stage clinical trials, many of which harness the potent FcγR-mediated effector systems to varying degrees. | 2020-04-14 |
| 32157849 | Take epidemiological history, fever, and the blood lymphocytes decline as clinical indicators, used CT to evaluate the possibility of COVID-19 and range of lung involvement. […] The Xiangya process was constructed according to multi-index, compared with clinical indicators, CT results and national standards, the efficiency of detecting confirmed cases were verified in the test and verification library. Results: A continuous cohort of 382 adults who screened COVID-19 was included in which 261 cases were in the test library and 121 cases were in the verification library. […] Compared with clinical indicators, the sensitivity and specificity of CT were 0.950 and 0.704, respectively. | 2020-03-11 |
| 32157862 | Three days later, levofloxacin was started because the patient’s symptoms did not improve. | 2020-04-15 |
| 32159317 | Objective: By analyzing the epidemic characteristics and related indicators of SARS (2003) and COVID-19(2020), to explore the reasons for the similarities and differences of the two epidemics, so as to provide reference for epidemic prevention and control. Methods: The general situation, clinical classification, activity history, contact history, family members’ contact and incidence of the two infectious diseases in Guangzhou were collected and used to analyze the time characteristics, occupational characteristics, age characteristics and other key indicators of the two diseases, including the number of cases, composition ratio (%), mean, median, crude mortality, etc. Results: A total of 1 072 cases of SARS (2003) were included in the study. 353 of which were severe cases with the incidence of 30.13%. 43 cases of death were reported with a mortality rate of 4.01%. | 2020-03-11 |
| 32161092 | Furthermore, we discuss the clinical features and potential therapeutic options that may be effective against SARS-CoV-2. | 2020-03-12 |
| 32161940 | Demographic and clinical data of all confirmed cases with COVID-19 on admission at Tongji Hospital from January 10 to February 12, 2020, were collected and analyzed. […] The most common symptoms were fever, shortness of breath, expectoration, fatigue, dry cough and myalgia. | 2020-04-03 |
| 32161968 | Its impacts on public health make it paramount to clarify the clinical features with other pneumonias. […] We analyzed the demographic, epidemiological, clinical, and radiological features from those patients, and compared the difference between NCOVID-19 and NON-NCOVID-19. […] The clinical symptoms were similar between NCOVID-19 and NON-NCOVID-19. […] The most common symptoms were fever and cough. | 2020-04-03 |
| 32162081 | We recorded findings at any chest CT performed in the included children, along with core clinical observations. […] Three of these five had CT abnormality on the first CT scan (at 2 days, 4 days and 9 days, respectively, after onset of symptoms) in the form of patchy ground-glass opacities; all normalised during treatment. | 2020-03-12 |
| 32162212 | These include engineering controls such as identification and preparation of an isolation operating room, administrative measures such as modification of workflow and processes, introduction of personal protective equipment for staff, and formulation of clinical guidelines for anesthetic management. | 2020-04-04 |
| 32162699 | The main clinical manifestations were respiratory symptoms and occasional gastrointestinal symptoms. […] In the retrospective analysis, we report nine cases of COVID-19, describe the history of contact, clinical manifestations, the course of diagnosis and clinical treatment before, during and after treatment. | 2020-03-16 |
| 32162702 | The aim of this study was to analyze the clinical data, discharge rate, and fatality rate of COVID-19 patients for clinical help. […] The clinical data of COVID-19 patients from December 2019 to February 2020 were retrieved from four databases. […] We statistically analyzed the clinical symptoms and laboratory results of COVID-19 patients and explained the discharge rate and fatality rate with a single-arm meta-analysis. […] The main clinical symptoms of COVID-19 patients were fever (88.5%), cough (68.6%), myalgia or fatigue (35.8%), expectoration (28.2%), and dyspnea (21.9%). […] Minor symptoms include headache or dizziness (12.1%), diarrhea (4.8%), nausea and vomiting (3.9%). | 2020-04-10 |
| 32164078 | Based on current studies, the author summarized the clinical characteristics and evolution of the novel viral pneumonia, and proposed the key points of diagnosis and treatment, the scientific management of both confirmed and suspected cases, and the scientific management of disease prevention and control. | 2020-03-13 |
| 32164079 | The novel coronavirus has the characteristics of rapid transmission, atypical clinical symptoms, and easy to affect both lungs, leading to missed diagnosis and misdiagnosis, as well as difficult to detection and assessment at early stage. | 2020-03-13 |
| 32164080 | Antiviral drugs commonly used in clinical practice, including neuraminidase inhibitors (oseltamivir, paramivir, zanamivir, etc.), ganciclovir, acyclovir and ribavirin, are invalid for 2019-nCoV and not recommended. […] But the efficacy and safety of these drugs for 2019-nCoV pneumonia patients need to be assessed by further clinical trials. | 2020-03-13 |
| 32164087 | Based on the clinical data of novel coronavirus pneumonia (NCP), as well as the dada from previous clinical studies and the recommendations from the Extracorporeal Life Support Organization (ELSO), the committee board of the Chinese Society of Extracorporeal Life Support (CSECLS) made this recommendations to guide clinical ECMO application in the patients with NCP. | 2020-03-13 |
| 32164089 | Objective: To analyze the clinical characteristics of 2019 novel coronavirus (2019-nCoV) pneumonia and to investigate the correlation between serum inflammatory cytokines and severity of the disease. […] Clinical data were collected and the general information, clinical symptoms, blood test and CT imaging characteristics were analyzed. […] The expression levels of inflammatory cytokines and other markers in the serum of each group were detected, and the changes of these indicators of the three groups were compared and analyzed, as well as their relationship with the clinical classification of the disease. […] Results: (1) The main symptoms of 2019-nCoV pneumonia was fever (28/29) with or without respiratory and other systemic symptoms. […] Conclusion: The clinical characteristics of 2019-nCoV pneumonia are similar to those of common viral pneumonia. | 2020-03-13 |
| 32164090 | Objective: To investigate the clinical characteristics of medical staff with novel coronavirus pneumonia(NCP). […] The data reviewed included those of clinical manifestations, laboratory investigation and Radiographic features. […] The average contact times were 12 (7,16) and the average cumulative contact time was 2 (1.5,2.7) h.Clinical symptoms of these patients were fever in 23 patients (76.67%) , headache in 16 petients (53.33%) , fatigue or myalgia in 21patients (70%) , nausea, vomiting or diarrhea in 9 petients (30%) , cough in 25 petients (83.33%) , and dyspnea in 14 petients (46.67%) . | 2020-03-13 |
| 32164091 | Objective: To summarize and analyze the clinical and imaging characteristics of patients with 2019 novel coronavirus pneumonia in the early stage in Beijing. […] Methods: A retrospective analysis of clinical and imaging data of 9 patients with 2019 novel coronavirus infection diagnosed in one fever clinicic in Beijing from January 18, 2020 to February 3, 2020. […] The clinical manifestations were fever in 8 cases (8/9) , dry cough in 5 cases (5/9) , pharyngalgia in 4 cases (4/9) , fatigue in 4 cases (4/9) , body soreness in 4 cases (4/9) , and blocked or watery nose in 1 case (1/9) . […] The clinical manifestations are fever and cough. | 2020-03-13 |
| 32164092 | Animal studies have shown that RAS inhibitors could effectively relieve symptoms of acute severe pneumonia and respiratory failure. | 2020-03-13 |
| 32164400 | Objective: To investigate the clinical and epidemiological characteristics of 135 confirmed cases of COVID-19 in Tianjin. Methods: The clinical and epidemiological data of 135 cases of COVID-19 in Tianjin were collected, and the data were analyzed with descriptive method. | 2020-03-13 |
| 32164424 | Similar to outbreaks of other newly identified virus, there is no proven regimen from conventional medicine and most reports managed the patients with lopinavir/ritonavir, ribavirin, beta-interferon, glucocorticoid and supportive treatment with remdesivir undergoing clinical trial. […] We reviewed the latest national and provincial clinical guidelines, retrospective cohort studies, and case series regarding the treatment of COVID-19 by add-on Chinese medicine. […] We have also reviewed the clinical evidence generated from SARS and H1N1 management with hypothesized mechanisms and latest in silico findings to identify candidate Chinese medicines for the consideration of possible trials and management. | 2020-03-13 |
| 32165854 | However, the recent report on asymptomatic contact transmission of COVID-19 and travelers who passed the symptoms-based screening and tested positive for COVID-19 using reverse transcription polymerase chain reaction (RT-PCR) challenges this approach as body temperature screening may miss travelers incubating the disease or travelers concealing fever during travel. | 2020-03-28 |
| 32166607 | The symptoms are usually fever, cough, sore throat, breathlessness, fatigue, malaise among others. […] The computerized tomographic chest scan is usually abnormal even in those with no symptoms or mild disease. | 2020-03-23 |
| 32167166 | The analysis showed that the viral pp1ab has not changed in most isolates throughout the outbreak time, but interestingly a deletion of 8 aa in the virulence factor nonstructural protein 1 was found in a virus isolated from a Japanese patient that did not display critical symptoms. | 2020-03-20 |
| 32167180 | At present, the sensitivity of clinical nucleic acid detection is limited, and it is still unclear whether it is related to genetic variation. […] Establishment of the reference sequence for SARS-CoV-2 could benefit not only biological study of this virus but also diagnosis, clinical monitoring and intervention of SARS-CoV-2 infection in the future. | 2020-03-20 |
| 32167181 | Therefore, it is of crucial importance to study the initial clinical features of patients, to better differentiate between infected and uninfected patients outside Hubei. […] The initial clinical data of these patients, such as epidemiological features, symptoms, laboratory results, and chest computed tomography (CT) findings were collected using a standard case report form on admission. | 2020-03-24 |
| 32167524 | Risk factors for the clinical outcomes of COVID-19 pneumonia have not yet been well delineated. […] To describe the clinical characteristics and outcomes in patients with COVID-19 pneumonia who developed acute respiratory distress syndrome (ARDS) or died. […] Epidemiological, demographic, clinical, laboratory, management, treatment, and outcome data were also collected and analyzed. | 2020-03-17 |
| 32169119 | The clinical symptoms of COVID-19 patients include fever, cough, fatigue and a small population of patients appeared gastrointestinal infection symptoms. […] In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus. | 2020-03-19 |
| 32170559 | This report describes the identification, diagnosis, clinical course, and management of three cases from a family, suggests the expected therapeutic effects of SHL on COVID-19, and warrants further clinical trials. | 2020-03-14 |
| 32170560 | However, some patients also exhibit non-respiratory symptoms, such as kidney failure, implying that 2019-nCoV could also invade other organs. | 2020-03-14 |
| 32170865 | The purpose of this review is primarily to review the pathogen, clinical features, diagnosis, and treatment of COVID-19, but also to comment briefly on the epidemiology and pathology based on the current evidence. | 2020-03-29 |
| 32171076 | Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. […] Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. | 2020-04-03 |
| 32171189 | Based on the clinical observation, the possibility of aerosol transmission of 2019 novel coronavirus has aroused much attention. | 2020-03-15 |
| 32171190 | Objective: To analyze the clinical characteristics of the severe or critically ill patients with novel coronavirus pneumonia (COVID-19), and evaluate the impact of complicated myocardial injury on the prognosis of these patients. […] The clinical characteristics and hospital mortality rate were analyzed and compared between the patients with or without myocardial injury, which was defined with 3 times higher serum cardiac troponin value. | 2020-03-15 |
| 32171192 | Descriptive analysis was used to analyze the clinical symptoms and the serial interval between the subsequent cases and the index cases. […] The clinical symptoms between family index cases and subsequent cases are similar, fever is the most common symptoms in the two groups 114 (77.03%) and 92 (48.68%) respectively, the cases with diarrhea symptoms accounted for the least proportion, which were 7 (4.73%) and 5 (2.65%). | 2020-03-15 |
| 32171865 | We aimed to investigate the clinical and CT features in the pregnant women and children with this disease, which have not been well reported. […] Clinical and CT data of 59 patients with COVID-19 from January 27 to February 14, 2020 were retrospectively reviewed, including 14 laboratory-confirmed non-pregnant adults, 16 laboratory-confirmed and 25 clinically-diagnosed pregnant women, and 4 laboratory-confirmed children. […] The clinical and CT features were analyzed and compared. […] Atypical clinical findings of pregnant women with COVID-19 could increase the difficulty in initial identification. […] CT was the modality of choice for early detection, severity assessment, and timely therapeutic effects evaluation for the cases with epidemic and clinical features of COVID-19 with or without laboratory confirmation. […] The exposure history and clinical symptoms were more helpful for screening in children versus chest CT. | 2020-04-16 |
| 32171866 | Due to the general susceptibility of new coronaviruses, the clinical characteristics and outcomes of elderly and young patients may be different. […] To analyze the clinical characteristics of elderly patients with 2019 new-type coronavirus pneumonia (COVID-19). […] Compare the clinical characteristics of elderly with Young and Middle-aged patients. […] The most common symptoms in both groups were fever, followed by cough and sputum. | 2020-04-01 |
| 32171867 | This study aimed to evaluate the clinical characteristics of the SARS-CoV-2 reactivation. […] Clinical records, laboratory results, and chest CT scans were retrospectively reviewed for 55 patients with laboratory-confirmed COVID-19 pneumonia (i.e., with throat swab samples that were positive for SARS-CoV-2) who were admitted to Zhongnan Hospital of Wuhan University, Wuhan, China, from Jan. 8 to Feb. […] Among the 5 reactivated patients, other symptoms were also observed, including fever, cough, sore throat, and fatigue. […] Findings from this small group of cases suggested that there was currently evidence for reactivation of SARS-CoV-2 and there might be no specific clinical characteristics to distinguish them. | 2020-04-16 |
| 32171869 | Studies on the 2019 novel coronavirus disease (COVID-19) have generally been limited to the description of the epidemiology and initial clinical characteristics. […] The duration from onset of symptoms to hospitalization was 4(2-7) days in symptomatic patients. […] The estimated median duration of fever in all the patients with fever was 10 days (95 confidential intervals [CIs]: 8-11 days) after onset of symptoms. […] Patients who were transferred to intensive care units (ICU) had significantly longer duration of fever as compared to those not in ICU (31 days v.s. 9 days after onset of symptoms, respectively, P <0.0001). […] Radiological aggravation of initial image was observed in 163 (65.7%) patients on day 7 after onset of symptoms. […] The clinical progression pattern suggests that early control of viral replication and application of host-directed therapy in later stage is essential to improve the prognosis of CVOID-19. | 2020-04-16 |
| 32171872 | Baseline clinical, laboratory, and chest CT characteristics were similar between groups. […] In patients with COVID-19, the apparent favorable clinical response with arbidol and LPV/r supports further LPV/r only. | 2020-04-16 |
| 32171952 | This paper aggregates and consolidates the epidemiology, clinical manifestations, diagnosis, treatments and preventions of this new type of coronavirus. | 2020-04-01 |
| 32172226 | Up to now, clinical features and treatment of patients infected with SARS-CoV-2 have been reported in detail. | 2020-04-01 |
| 32172228 | Some practical indications can hence be identified for minimizing the risk of diagnostic errors, encompassing the improvement of diagnostic accuracy by combining clinical evidence with results of chest computed tomography (CT) and RT-PCR, interpretation of RT-PCR results according to epidemiologic, clinical and radiological factors, recollection and testing of upper (or lower) respiratory specimens in patients with negative RT-PCR test results and high suspicion or probability of infection, dissemination of clear instructions for specimen (especially swab) collection, management and storage, together with refinement of molecular target(s) and thorough compliance with analytical procedures, including quality assurance. | 2020-04-01 |
| 32172546 | Objective: To investigate the pathological characteristics and the clinical significance of novel coronavirus (2019-nCoV)-infected pneumonia (termed by WHO as corona virus disease 2019, COVID-19). Methods: Minimally invasive autopsies from lung, heart, kidney, spleen, bone marrow, liver, pancreas, stomach, intestine, thyroid and skin were performed on three patients died of novel coronavirus pneumonia in Chongqing, China. | 2020-03-15 |
| 32172669 | The clinical features include fever, coughing, shortness of breath, and inflammatory lung infiltration. | 2020-03-17 |
| 32172672 | Human infection with SARS-CoV-2 leads to a wide range of clinical manifestations ranging from asymptomatic, mild, moderate to severe. | 2020-03-17 |
| 32173110 | We included six articles (one narrative letter, one in-vitro study, one editorial, expert consensus paper, two national guideline documents) and 23 ongoing clinical trials in China. […] There is rationale, pre-clinical evidence of effectiveness and evidence of safety from long-time clinical use for other indications to justify clinical research on chloroquine in patients with COVID-19. […] However, clinical use should either adhere to the Monitored Emergency Use of Unregistered Interventions (MEURI) framework or be ethically approved as a trial as stated by the World Health Organization. […] Safety data and data from high-quality clinical trials are urgently needed. | 2020-03-16 |
| 32173188 | On 31 December 2019, the Wuhan Municipal Committee of Health and Healthcare (Hubei Province, China) reported that there were 27 cases of pneumonia of unknown origin with symptoms starting on the 8 December. […] The Ministry of Health summoned the Specialties Societies to prepare a clinical protocol for the management of COVID-19. | 2020-04-04 |
| 32173241 | To date, effective treatment is lacking; however, clinical trials investigating the efficacy of several agents, including remdesivir and chloroquine, are underway in China. | 2020-04-09 |
| 32173574 | The result showed the most prevalent clinical symptom was fever ( 91 ± 3, 95% CI 86-97% ), followed by cough (67 ± 7, 95% CI 59-76%), fatigue ( 51 ± 0, 95% CI 34-68% ) and dyspnea ( 30 ± 4, 95% CI 21-40%). | 2020-03-16 |
| 32173576 | To explore the epidemiological information, clinical characteristics, therapeutic outcomes and temporal progression of laboratory findings in 2019-coronavirus disease (COVID-19) patients exposed to lopinavir. […] Mainly initial symptoms were cough and low fever (37.3-38.0 ℃). | 2020-03-16 |
| 32173725 | The cases were divided into general and refractory COVID-19 groups according to the clinical efficacy after hospitalization, and the difference between groups were compared. […] Nearly 50% COVID-19 patients could not reach obvious clinical and radiological remission within 10 days after hospitalization. | 2020-03-16 |
| 32174053 | Here, we report two representative false-negative cases and discuss the supplementary role of clinical data with rRT-PCR, including laboratory examination results and computed tomography features. | 2020-03-24 |
| 32174095 | Extensive epidemiological, viral immunological, and current clinical evidences support the possibility that pulmonary fibrosis may be one of the major complications in COVID-19 patients. | 2020-03-16 |
| 32174096 | Objective: To explore the management strategies for patients with gynecological malignant tumors during the outbreak and transmission of COVID19. Methods: We retrospectively analyzed the clinical characteristics, treatment, and disease outcomes of three patients with gynecological malignancies associated with COVID19 in Renmin Hospital of Wuhan University in January 2020, and proposed management strategies for patients with gynecological tumors under risk of COVID19. Results: Three patients were treated COVID19 based on the national diagnosis and treatment protocol as well as research progress. […] Meanwhile, these patients were appropriately adjusted the treatment plan in accordance with the clinical guidelines for gynecological tumors. | 2020-03-16 |
| 32174128 | The purpose of this study was to assess the clinical features and CT manifestations of COVID-19 by comparing patients with COVID-19 pneumonia with patients with non-COVID-19 pneumonia who presented at a fever observation department in Shanghai, China. MATERIALS AND METHODS. Patients were retrospectively enrolled in the study from January 19 through February 6, 2020. […] No statistical difference in clinical features was observed (p > 0.05), with the exception of leukocyte and platelet counts (p < 0.05). […] The mean (± SD) interval between onset of symptoms and admission to the fever observation department was 4.40 ± 2.00 and 5.52 ± 4.00 days for patients with positive and negative RT-PCR test results, respectively. | 2020-03-16 |
| 32174129 | Imaging patterns corresponding to clinical improvement usually occur after week 2 of the disease and include gradual resolution of consolidative opacities and decrease in the number of lesions and involved lobes. CONCLUSION. This systematic review of current literature on COVID-19 provides insight into the initial and follow-up CT characteristics of the disease. | 2020-03-16 |
| 32175637 | Clinical data of fatal cases published by the Chinese Government were studied. […] As of 2 February 2020, the clinical data of 46 fatal cases were identified. | 2020-03-16 |
| 32175797 | Clinical entities such as conjunctivitis, anterior uveitis, retinitis, and optic neuritis have been documented in feline and murine models. | 2020-04-13 |
| 32176772 | Related clinical features are needed. […] The most common symptoms were fever (60[87%]), cough (38[55%]), and fatigue (29[42%]). | 2020-03-16 |
| 32178954 | The aim of the present study was to prevent cross-infection in the operating room during emergency procedures for patients with confirmed or suspected 2019 novel coronavirus (2019-nCoV) by following anesthesia management protocols, and to document clinical- and anesthesia-related characteristics of these patients. […] This was a retrospective, multicenter clinical study. | 2020-04-08 |
| 32178975 | Low platelet count is associated with increased risk of severe disease and mortality in patients with COVID-19, and thus should serve as clinical indicator of worsening illness during hospitalization. | 2020-04-14 |
| 32179124 | Clinical, laboratory, and imaging features have been partially characterized in some observational studies. […] We performed a systematic literature review with meta-analysis, using three databases to assess clinical, laboratory, imaging features, and outcomes of COVID-19 confirmed cases. | 2020-04-01 |
| 32179140 | To compare the clinical characteristics and the dynamics of viral load between the imported and non-imported patients with COVID-19. […] COVID-19 can present as pneumonia with less onset of symptoms, and the infectivity of SARS-CoV2 may gradually decrease in the tertiary patients. | 2020-03-17 |
| 32179660 | Although clinical manifestations of children’s COVID-19 cases were generally less severe than those of adult patients, young children, particularly infants, were vulnerable to infection. | 2020-04-09 |
| 32179908 | We report a 55-day-old case with COVID-19 confirmed in China and describe the identification, diagnosis, clinical course, and treatment of the patient, including the disease progression from day 7 to day 11 of illness. […] When managing such patients, frequent and careful clinical monitoring is essential. | 2020-03-17 |
| 32179910 | We study epidemiological and clinical outcome of 55 asymptomatic carriers who were laboratory-confirmed positive for the SARS-Coronavirus-2 by testing the nucleic acid of the pharyngeal swab samples. | 2020-03-17 |
| 32180140 | Both clinical features and laboratory examination results of the children and their family members were described. […] The two confirmed children only presented with mild respiratory or gastrointestinal symptoms. […] Infected children have relatively milder clinical symptoms than infected adults. | 2020-03-17 |
| 32180175 | We also recorded the patients’ demographic and clinical characteristics, anesthesia and surgery-related data, maternal and neonatal complications, as well as the health status of the involved medical staff. […] The clinical characteristics of 17 pregnant women infected with SARS-CoV-2 were similar to those previously reported in non-pregnant adult patients. | 2020-04-03 |
| 32180426 | In addition, it analyzes literature describing 38 pregnant women with COVID-19 and their newborns in China to assess the effects of SARS-CoV-2 on the mothers and infants including clinical, laboratory and virologic data, and the transmissibility of the virus from mother to fetus. | 2020-03-17 |
| 32181672 | OBJECTIVE. The purpose of this study was to investigate early clinical and CT manifestations of coronavirus disease (COVID-19) pneumonia. MATERIALS AND METHODS. Patients with COVID-19 pneumonia confirmed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid test (reverse transcription-polymerase chain reaction) were enrolled in this retrospective study. […] The clinical manifestations, laboratory results, and CT findings were evaluated. RESULTS. One hundred eight patients (38 men, 70 women; age range, 21-90 years) were included in the study. […] The clinical manifestations were fever in 94 of 108 (87%) patients, dry cough in 65 (60%), and fatigue in 42 (39%). […] Vascular thickening (86 patients [80%]), crazy paving pattern (43 patients [40%]), air bronchogram sign (52 patients [48%]), and halo sign (69 [64%]) were also observed in this study. CONCLUSION. The early clinical and laboratory findings of COVID-19 pneumonia are low to midgrade fever, dry cough, and fatigue with normal WBC count, reduced lymphocyte count, and elevated high-sensitivity C-reactive protein level. | 2020-03-17 |
| 32181807 | Recent studies have focused initial clinical and Epidemiologic characteristics on the COVID-19, mainly revealing situation in Wuhan, Hubei. […] To reveal more data on the epidemiologic and clinical characteristics of COVID-19 patients outside of Wuhan, in Zhejiang, China. […] Retrospective case series. 88 cases of laboratory-confirmed and 3 cases of clinical-confirmed COVID-19 were admitted to five hospitals in Zhejiang province, China. […] Of all 91 patients, 88 (96.70%) were laboratory-confirmed COVID-19 with throat swab samples that tested positive for SARS-Cov-2 while 3 (3.30%) were clinical-diagnosed COVID-19 cases. […] The most common symptoms were fever (71.43%), cough (60.44%) and fatigue (43.96%). | 2020-03-17 |
| 32181903 | Demographic, clinical, blood routine results, other laboratory results, and treatment data were collected and analyzed. | 2020-03-28 |
| 32181911 | The role of clinical laboratory data in the differential diagnosis of the severe forms of COVID-19 has not been definitely established. […] IL-6 and d-D were closely related to the occurrence of severe COVID-19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID-19 patients, which has important clinical value. | 2020-04-10 |
| 32181990 | We report here the clinical features and therapeutic course of the first reported renal transplant recipient with confirmed COVID-19 pneumonia. […] His overall clinical characteristics (symptoms, laboratory examinations, and chest CT) were similar to those of non-transplanted COVID-19 patients. | 2020-04-01 |
| 32183901 | In this scoping review, 65 research articles published before 31 January 2020 were analyzed and discussed to better understand the epidemiology, causes, clinical diagnosis, prevention and control of this virus. […] Reported symptoms include fever, cough, fatigue, pneumonia, headache, diarrhea, hemoptysis, and dyspnea. […] During this early period, published research primarily explored the epidemiology, causes, clinical manifestation and diagnosis, as well as prevention and control of the novel coronavirus. | 2020-03-19 |
| 32183934 | During the post-discharge surveillance after clinical recovery, swabs were positive in two asymptomatic cases (3.23%). […] Case 1 had presented typical clinical and radiological manifestations on admission, while manifestation in Case 2 was very mild. | 2020-03-23 |
| 32185921 | Due to the extensive spread and high transmission ability of the COVID-19, there is a possibility of virus infections among malaria cases during the medical care-seeking behaviors and among healthcare professionals during clinical diagnosis and treatment, sample collection and testing and epidemiological surveys. | 2020-03-19 |
| 32186171 | Objective: Analyzing the symptom characteristics of Coronavirus Disease 2019(COVID-19) to improve its prevention. Methods: Using Baidu Index Platform (http://index.baidu.com) and the website of Chinese Center for Disease Control and Prevention as data resources to obtain the search volume (SV) of keywords for symptoms associated with COVID-19 from January 1 to February 20 in each year from 2017 to 2020, in Hubei province and other top 10 impacted provinces in China and the epidemic data. […] The differences and characteristics of the SV of COVID-19-related symptoms, and the correlation between the SV of COVID-19 and new confirmed or suspected cases were analyzed and the hysteresis effects were discussed. Results: Compared the data from January 1 to February 20, 2020, with the SV for the same period of previous three years, Hubei’s SV for cough, fever, diarrhea, chest tightness, dyspnea and other symptoms were significantly increased. […] The total SV of lower respiratory symptoms was significantly higher than that of upper respiratory symptoms (P<0.001). […] The results of the distributed lag model suggested that the patients who retrieved relevant symptoms on the Internet may begin to see a doctor in 2-3 days later and be diagnosed in 3-4 days later. Conclusions: The total SV of lower respiratory symptoms is higher than that of upper respiratory symptoms, and the SV of diarrhea also increased significantly. […] It warns us to pay attention to not only the symptoms of lower respiratory tract, but also the gastrointestinal symptoms, especially diarrhea in patients with COVID-19. | 2020-03-18 |
| 32186894 | OBJECTIVE. The purpose of this study was to describe the clinical manifestations and CT features of coronavirus disease (COVID-19) pneumonia in 15 pregnant women and to provide some initial evidence that can be used for guiding treatment of pregnant women with COVID-19 pneumonia. MATERIALS AND METHODS. We reviewed the clinical data and CT examinations of 15 consecutive pregnant women with COVID-19 pneumonia in our hospital from January 20, 2020, to February 10, 2020. […] Symptoms and laboratory results were analyzed, treatment experiences were summarized, and clinical outcomes were tracked. RESULTS. Eleven patients had successful delivery (10 cesarean deliveries and one vaginal delivery) during the study period, and four patients were still pregnant (three in the second trimester and one in the third trimester) at the end of the study period. […] The most common onset symptoms of COVID-19 pneumonia in pregnant women were fever (13/15 patients) and cough (9/15 patients). […] The four patients who were still pregnant at the end of the study period were not treated with antiviral drugs but had achieved good recovery. CONCLUSION. Pregnancy and childbirth did not aggravate the course of symptoms or CT features of COVID-19 pneumonia. | 2020-03-18 |
| 32187464 | The primary end point was the time to clinical improvement, defined as the time from randomization to either an improvement of two points on a seven-category ordinal scale or discharge from the hospital, whichever came first. […] Treatment with lopinavir-ritonavir was not associated with a difference from standard care in the time to clinical improvement (hazard ratio for clinical improvement, 1.24; 95% confidence interval [CI], 0.90 to 1.72). […] In a modified intention-to-treat analysis, lopinavir-ritonavir led to a median time to clinical improvement that was shorter by 1 day than that observed with standard care (hazard ratio, 1.39; 95% CI, 1.00 to 1.91). […] (Funded by Major Projects of National Science and Technology on New Drug Creation and Development and others; Chinese Clinical Trial Register number, ChiCTR2000029308.). | 2020-04-12 |
| 32187887 | From the perspective of clinical pediatricians as the first line fighting the epidemic, this paper will discuss the clinical characteristics, prevention and control measures, outcomes, diagnosis, and treatment of pediatric cases. | 2020-04-16 |
| 32187920 | The 2019 coronavirus disease(COVID-19) is a highly infectious disease, has a long incubation period and a variety of clinical manifestations, which has a significant impact on public health and life. […] In order to implement the central government’s decision-making deployment and defeat the COVID-19 as soon as possible, we had focused on the key points in the clinical work of general surgery according to latest relevant guidelines, literature and experience in epidemic prevention. | 2020-03-19 |
| 32187929 | The outbreak of pneumonia caused by the novel coronavirus (2019-nCoV) in Wuhan, Hubei province of China, at the end of 2019 shaped tremendous challenges to China’s public health and clinical treatment. […] The virus belongs to the β genus Coronavirus in the family Corornaviridae, and is closely related to SARS-CoV and MERS-CoV, causing severe symptoms of pneumonia. […] After the outbreak of this disease, Chinese scientists invested a lot of energy to carry out research by developing rapid diagnostic reagents, identifying the characters of the pathogen, screening out clinical drugs that may inhibit the virus, and are rapidly developing vaccines. | 2020-03-19 |
| 32189015 | Unlike other acute infectious diseases progressing to sepsis, the severe courses of COVID19 seemingly show prolonged progression from onset of first symptoms to life-threatening deterioration of (primarily) lung function. | 2020-04-10 |
| 32189081 | Beside clinical procedures and treatments, since Artificial Intelligence (AI) promises a new paradigm for healthcare, several different AI tools that are built upon Machine Learning (ML) algorithms are employed for analyzing data and decision-making processes. | 2020-03-20 |
| 32189428 | While approximately 80% of infected individuals have minimal symptoms, around 15-20% need to be hospitalized, greatly stressing global healthcare systems. | 2020-03-30 |
| 32190904 | Here we reported the screening, clinical feathers, and treatment process of a family cluster involving three COVID-19 patients. | 2020-03-19 |
| 32190908 | To better understand its dynamics in Italy, we analyzed complete genomes of SARS-CoV-2 isolates, obtained directly from clinical samples. | 2020-03-28 |
| 32191174 | After initial assessment for symptoms and epidemiological risk factors, including travel to affected areas and exposure to confirmed 2019-nCoV patients within 14 days, patients are classified in a risk-stratified system. | 2020-03-23 |
| 32191623 | Despite there being evidence that laboratory tests are vital throughout many clinical pathways, there are at least three major areas where in vitro diagnostics can also provide essential contributions to diagnostic reasoning and managed care of patients with suspected or confirmed SARS-CoV-2 infection. […] Some proactive and reactive strategies may hence be identified to confront this serious healthcare challenge, which entail major investments on conventional laboratory resources, reinforcement of regional networks of clinical laboratories, installation of mobile laboratories, as well as being proactive in establishing laboratory emergency plans. | 2020-04-01 |
| 32191691 | Singapore adopted a multipronged surveillance strategy that included applying the case definition at medical consults, tracing contacts of patients with laboratory-confirmed COVID-19, enhancing surveillance among different patient groups (all patients with pneumonia, hospitalized patients in intensive care units [ICUs] with possible infectious diseases, primary care patients with influenza-like illness, and deaths from possible infectious etiologies), and allowing clinician discretion (i.e., option to order a test based on clinical suspicion, even if the case definition was not met) to identify COVID-19 patients. […] Application of the case definition and contact tracing identified 73 patients, 16 were detected by enhanced surveillance, and 11 were identified by laboratory testing based on providers’ clinical discretion. | 2020-03-20 |
| 32191764 | We retrospective studied 27 consecutive patients who were confirmed NCIP, the clinical characteristics and CT image findings were collected, and the association of radiologic findings with mortality of patients was evaluated. 27 patients included 12 men and 15 women, with median age of 60 years (IQR 47-69). 17 patients discharged in recovered condition and 10 patients died in hospital. | 2020-03-25 |
| 32191813 | There are likely many people with undetected SARS-CoV-2 infection because testing efforts are currently not detecting all infected people, including some with clinical disease compatible with COVID-19. | 2020-03-25 |
| 32191830 | Spreading mainly through the droplet route, the virus causes mild symptoms in the majority of cases, the most common being: fever (80%), dry cough (56%), fatigue (22%) and muscle pain (7%); less common symptoms include a sore throat, a runny nose, diarrhea, hemoptysis and chills. […] The article presents basic information about etiology, pathogenesis and diagnostics (with particular emphasis on the importance of tomocomputer imaging), clinical picture, treatment and prevention of the infection. | 2020-03-26 |
| 32192278 | These measures for early detection and screening of cases should be followed by full efforts to produce research-based evidence by thoroughly analyzing epidemiological, clinical and immunological data, which will facilitate the development of vaccines and therapeutics for COVID-19. | 2020-04-08 |
| 32192296 | Although colorectal surgery is not a front-line subject in the fight against the epidemic, but in this special situation, it is a difficult task to provide the highest quality medical services and ensure the orderly clinical work, on the premise of maximizing the protection for patients and their families, health of medical staff, and the safety of wards and hospitals, We summarize how to carry out the clinical practice of colorectal surgery under the situation of the prevention and control of the COVID-19 epidemiology, including the procedures of diagnose and treatment for emergency patients with colorectal tumor, and share the experiences of the diagnosis of colorectal tumor, the management of patients with colorectal cancer who are scheduled to be admitted for surgery, the protection of wards, the perioperative management. | 2020-03-23 |
| 32192297 | Clinicians should make individual clinical decisions based on the specifics of each patient during epidemic situation. | 2020-03-23 |
| 32192580 | We gathered epidemiological and clinical data from individuals with confirmed COVID-19, via interviews and inpatient medical records, and we did field investigations to assess interactions and possible modes of transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). | 2020-04-03 |
| 32193037 | The CT manifestations and clinical data of 73 patients with COVID-19 were retrospectively collected in 6 hospitals from Jan 21 to Feb 3, 2020. | 2020-04-10 |
| 32193831 | We aimed to describe the clinical features of severe pediatric patients with COVID-19. […] We collected information including demographic data, symptoms, imaging data, laboratory findings, treatments and clinical outcomes of the patients with severe COVID-19. […] The most common symptoms were polypnea (8/8), followed by fever (6/8) and cough (6/8). | 2020-03-20 |
| 32193905 | In this report, we present mild clinical course of her pneumonia that did not require antiviral treatment and serial viral test results from multiple specimens. | 2020-03-23 |
| 32194253 | Elseways, the recurrent virus exposure over a short time-lapse might result in the Antibody Dependent Enhancement, triggering the violent immune reaction responsible for the severe clinical outcomes observed in the Hubei province. | 2020-04-01 |
| 32195887 | Clinical, laboratory, and computed tomography (CT) findings of 5 cases of the novel Coronavirus Disease 2019 (COVID-19) pneumonia from patients outside of Wuhan were reviewed. […] With a history of exposure or travelling, symptoms of fever and cough, and the typical CT manifestation such as ground-glass opacity with a peripheral distribution, we should also think of the possibility of the COVID-19 pneumonia in patients outside of Wuhan. | 2020-03-20 |
| 32196083 | The transition from first symptoms to acute respiratory distress syndrome (ARDS) is highly likely to be due to uncontrolled cytokine release. […] However, the clinical use of CQ can cause severe side effects. […] It has a safer clinical profile and is suitable for those who are pregnant. […] We herein strongly urge that clinical trials are performed to assess the preventive effects of HCQ in both disease infection and progression. | 2020-03-20 |
| 32196410 | Although most patients have mild symptoms and good prognosis after infection, some patients developed severe and die from multiple organ complications. | 2020-04-07 |
| 32196655 | To provide clinical management guidelines for novel coronavirus (COVID-19) in pregnancy. | 2020-04-13 |
| 32196678 | We aim to describe here the various clinical presentations of this disease by examining eleven cases. […] Electronic medical records of 11 patients with COVID-19 were collected, and demographics, clinical manifestations, outcomes, key laboratory results, and radiological images are discussed. […] The clinical course of the eleven cases demonstrated the complexity of the COVID-19 profile with different clinical presentations. […] Clinical manifestations range from asymptomatic cases to patients with mild and severe symptoms, with or without pneumonia. […] Patients with common allergic diseases did not develop distinct symptoms and severe courses. […] All different clinical characteristics of COVID-19 should be taken into consideration to identify patients that need to be in strict quarantine for the efficient containment of the pandemic. | 2020-04-06 |
| 32196707 | In this study, we describe the clinical characteristics of those patients who got infected with COVID-19 as well as influenza virus. […] Common symptoms at onset of illness included fever (five [100%] patients), cough (five [100%] patients), shortness of breath (five [100%] patients), nasal tampon (three [60%] patients), pharyngalgia (three [60%] patients), myalgia (two [40%] patients), fatigue (two [40%] patients), headache (two [40%] patients), and expectoration (two [40%] patients). […] In conclusion, those patients with both COVID-19 and influenza virus infection did not appear to show a more severe condition because based on the laboratory findings, imaging studies, and patient prognosis, they showed similar clinical characteristics as those patients with COVID-19 infection only. […] However, it is worth noting that the symptoms of nasal tampon and pharyngalgia may be more prone to appear for those coinfection patients. | 2020-03-31 |
| 32197060 | Rapid clinical recognition of rhabdomyolysis symptoms in patients with severe acute respiratory syndrome coronavirus 2 infection can be lifesaving. | 2020-03-20 |
| 32197787 | Infections in humans cause a broad clinical spectrum ranging from mild upper respiratory tract infection, to severe acute respiratory distress syndrome and sepsis. | 2020-04-01 |
| 32198163 | Clinical trials are needed to determine whether this drug combination might be used to treat patients with severe COVID-19 infection. | 2020-03-25 |
| 32198501 | Humoral response to SARS-CoV-2 can aid to the diagnosis of COVID-19, including subclinical cases. | 2020-03-21 |
| 32198776 | Epidemiological, clinical features, laboratory findings, radiological characteristics, treatment, and clinical outcomes of 135 patients in northeast Chongqing were collected and analyzed in this study. […] Common symptoms included fever (120 [88.9%]), cough (102 [76.5%]), and fatigue (44 [32.5%]). | 2020-04-02 |
| 32198834 | COVID-19 is novel infectious disease with an evolving understanding of its epidemiology and clinical manifestations. […] Herein we report a case of a COVID-19 infection in a solid organ transplant recipient, in which the first clinical symptoms were of gastrointestinal viral disease and fever, which further progressed to respiratory symptoms in 48 hours. | 2020-04-10 |
| 32198915 | Clinicians need to comprehensively analyze the epidemic history, disease onset characteristics, clinical manifestations, image characteristics, serological andpathogenic microorganism test results to confirm diagnosis. | 2020-03-21 |
| 32198985 | Based on related laws and regulations, such as the Law of the People’s Republic of China on Prevention and Control of Infectious Diseases, the clinical manifestations and epidemiological characteristics of COVID-19, and the related guidelines on the prevention and control of the outbreak, combined with the practical work of forensic pathology examination, the Guide to the Forensic Pathology Practice on Death Cases Related to Corona Virus Disease 2019 （COVID-19） （Trial Draft） has been developed. | 2020-04-08 |
| 32199619 | To investigate the characteristics and clinical value of chest computed tomography (CT) images of novel coronavirus pneumonia (NCP). […] Clinical data and CT images of 80 cases of NCP were collected. […] The clinical manifestations and laboratory test results of the patients were analysed. […] The main clinical manifestations were fever, dry cough, fatigue, a little white sputum, or diarrhoea. | 2020-04-16 |
| 32199996 | Most often at the origin of a mild infectious syndrome, associating mild symptoms (fever, cough, myalgia, headache and possible digestive disorders) to different degrees, SARS-Covid-2 can cause serious pulmonary pathologies and sometimes death. […] The first Chinese data published seem to show that the symptoms in pregnant women are the same as those of the general population. […] Pregnancy is known as a period at higher risk for the consequences of respiratory infections, as for influenza, so it seems important to screen for Covid-19 in the presence of symptoms and to monitor closely pregnant women. | 2020-04-08 |
| 32200400 | As the clinical spectrum of COVID-19 ranges widely from mild illness to ARDS with a high risk of mortality, there is a need for more research to identify early markers of disease severity. | 2020-03-24 |
| 32200613 | Infections with the Coronaviridae virus family in a small percentage of patients, especially in those over 60 years of age with a positive clinical history, lead to severe acute respiratory syndrome [2]. | 2020-03-23 |
| 32201353 | Based on the current published evidence, we systematically summarizes the epidemiology, clinical characteristics, diagnosis, treatment and prevention of knowledge surrounding COVID-19. | 2020-04-16 |
| 32202240 | The two previously reported coronavirus epidemics (severe acute respiratory syndrome [SARS] and Middle East respiratory syndrome [MERS]) share similar pathogenetic, epidemiological and clinical features as COVID-19. | 2020-04-03 |
| 32202256 | Patients will be monitored to document clinical (hospital length of stay and mortality at 14, 28 and 90 days), laboratory (presence of viral RNA in serial throat swab samples) and safety (adverse events and serious adverse events) outcomes. […] Treatment outcomes amongst initial cases would be useful in providing guidance about the clinical management of patients with COVID-19. | 2020-03-23 |
| 32202261 | While there remained important uncertainties in the natural history of COVID-19, using hypothetical epidemic curves, some key findings were illustrated that appeared insensitive to model assumptions, as well as highlighting critical data gaps. :It was assumed that symptomatic quarantine would identify and quarantine 50 per cent of symptomatic individuals within three days of developing symptoms. […] In the pessimistic scenario of R0=4, and asymptomatic infections being half as infectious as symptomatic, this projected impact falls to two per cent. :Port-of-entry-based entry screening of travellers with suggestive clinical features and from COVID-19-affected countries, would achieve modest delays in the introduction of the virus into the community. | 2020-03-23 |
| 32202343 | Data on symptoms and prognosis in children are rare. […] Diagnostic findings have been similar to adults, with fever and respiratory symptoms being prevalent, but fewer children seem to have developed severe pneumonia. | 2020-04-14 |
| 32202401 | This document could be a valid tool to be used in routine clinical practice and, possibly, a cornerstone for further discussion on the topic also considering the further evolution of the COVID-19 pandemic. | 2020-03-23 |
| 32202646 | The degree of symptoms of depression, anxiety, insomnia, and distress was assessed by the Chinese versions of the 9-item Patient Health Questionnaire, the 7-item Generalized Anxiety Disorder scale, the 7-item Insomnia Severity Index, and the 22-item Impact of Event Scale-Revised, respectively. […] A considerable proportion of participants reported symptoms of depression (634 [50.4%]), anxiety (560 [44.6%]), insomnia (427 [34.0%]), and distress (899 [71.5%]). […] Nurses, women, frontline health care workers, and those working in Wuhan, China, reported more severe degrees of all measurements of mental health symptoms than other health care workers (eg, median [IQR] Patient Health Questionnaire scores among physicians vs nurses: 4.0 [1.0-7.0] vs 5.0 [2.0-8.0]; P = .007; median [interquartile range {IQR}] Generalized Anxiety Disorder scale scores among men vs women: 2.0 [0-6.0] vs 4.0 [1.0-7.0]; P < .001; median [IQR] Insomnia Severity Index scores among frontline vs second-line workers: 6.0 [2.0-11.0] vs 4.0 [1.0-8.0]; P < .001; median [IQR] Impact of Event Scale-Revised scores among those in Wuhan vs those in Hubei outside Wuhan and those outside Hubei: 21.0 [8.5-34.5] vs 18.0 [6.0-28.0] in Hubei outside Wuhan and 15.0 [4.0-26.0] outside Hubei; P < .001). […] Multivariable logistic regression analysis showed participants from outside Hubei province were associated with lower risk of experiencing symptoms of distress compared with those in Wuhan (odds ratio [OR], 0.62; 95% CI, 0.43-0.88; P = .008). […] Frontline health care workers engaged in direct diagnosis, treatment, and care of patients with COVID-19 were associated with a higher risk of symptoms of depression (OR, 1.52; 95% CI, 1.11-2.09; P = .01), anxiety (OR, 1.57; 95% CI, 1.22-2.02; P < .001), insomnia (OR, 2.97; 95% CI, 1.92-4.60; P < .001), and distress (OR, 1.60; 95% CI, 1.25-2.04; P < .001). | 2020-04-01 |
| 32203970 | Lastly, we discuss the clinical management of COVID-19 patients with existing chronic renal disorders, particularly those in dialysis and with kidney transplants. | 2020-03-23 |
| 32204411 | The aim of this study is to explore the impacts of COVID-19 on people’s mental health, to assist policy makers to develop actionable policies, and help clinical practitioners (e.g., social workers, psychiatrists, and psychologists) provide timely services to affected populations. […] It may provide references for policy makers to plan and fight against COVID-19 effectively by improving stability of popular feelings and urgently prepare clinical practitioners to deliver corresponding therapy foundations for the risk groups and affected people. | 2020-04-01 |
| 32204751 | At present there is limited clinical information of the SARS-CoV-2 and there is no specific treatment recommended, although technical guidances and suggestions have been developed and will continue to be updated as additional information becomes available. | 2020-03-26 |
| 32204752 | This plan has been verified by clinical practice for 3 weeks. […] With the further understanding of SARS-CoV-2 infection, especially the emergence of SARS-CoV-2 infection cases in pregnant women and neonates, it is necessary to update the first edition of the management plan so as to offer a better guide on clinical practice. | 2020-03-26 |
| 32204754 | Based on the further knowledge and experience on SARS-CoV-2 infection, the neonatologists updated the plan according to the current evidence, so as to provide a better guide for clinical medical staff to deal with the SARS-CoV-2 infection in the NICU. | 2020-03-26 |
| 32204755 | Most children with SARS-CoV-2 infection present mainly with respiratory symptoms, but less commonly with gastrointestinal symptoms, and tend to have mild clinical symptoms. | 2020-03-26 |
| 32204756 | To study the clinical features and chest CT findings of coronavirus disease 2019 (COVID-19) in infants and young children. […] A retrospective analysis was performed for the clinical data and chest CT images of 9 children, aged 0 to 3 years, who were diagnosed with COVID-19 by nucleic acid detection between January 20 and February 10, 2020. […] Among the 9 children with COVID-19, 5 had no symptoms, 4 had fever, 2 had cough, and 1 had rhinorrhea. […] There were only symptoms of the respiratory system. […] Infants and young children with COVID-19 tend to have mild clinical symptoms and imaging findings not as typical as those of adults, and therefore, the diagnosis of COVID-19 should be made based on imaging findings along with epidemiological history and nucleic acid detection. | 2020-03-26 |
| 32204757 | The two girls had mild symptoms and rapid recovery, suggesting that children with SARS-CoV-2 infection may be mild and have a good prognosis. […] There were differences in the clinical symptoms and imaging findings between the twin girls, suggesting that SARS-CoV-2 infection has diverse clinical features in children. | 2020-03-26 |
| 32205204 | Depending on their clinical presentation, azithromycin was added to the treatment. […] Six patients were asymptomatic, 22 had upper respiratory tract infection symptoms and eight had lower respiratory tract infection symptoms. | 2020-04-01 |
| 32205284 | To investigate the epidemiological, clinical characteristics of COVID-19 patients with abnormal imaging findings. […] Epidemiological, clinical data were analyzed between those with abnormal or normal imaging findings. […] Patients with abnormal images have more obvious clinical manifestations and laboratory changes. […] Combing clinical features and radiograph score can effectively predict severe/critical type. | 2020-03-24 |
| 32205349 | There is a growing understanding of SARS-CoV-2 in the virology, epidemiology and clinical management strategies. […] Recent studies have revealed many attractive threptic options, even if some of them remain to be further confirmed in rigorous preclinical models and clinical trials. | 2020-03-24 |
| 32207032 | Despite the rapidly increasing number of cases in subsequent weeks, the clinical characteristics of pediatric cases are rarely described. […] The demographic data, epidemiological history, underlying diseases, clinical manifestations, laboratory and radiological data, treatments, and outcomes were analyzed. […] The most common symptoms at onset of illness were fever (13 [52%]), and dry cough (11 [44%]). […] Clinical diagnoses included upper respiratory tract infection (n=8), mild pneumonia (n=15), and critical cases (n=2). […] The symptoms in 24 (96%) of 25 patients were alleviated and one patient had been discharged. […] It was concluded that children were susceptible to COVID-19 like adults, while the clinical presentations and outcomes were more favorable in children. | 2020-03-24 |
| 32207208 | Under specific circumstances, such as during the current COVID-19 outbreak, pregnant women can be a target for respiratory infection, and lung examination may be required as part of their clinical evaluation, ideally avoiding exposure to radiation. | 2020-03-24 |
| 32207542 | “Action at a distance” may be the new norm for clinical researchers in the context of the COVID-19 pandemic that may require social distancing for the next 18 months. […] Clinical researchers have an obligation to help, and we can. […] Recommendations for clinical researchers working with older adults during the COVID-19 pandemic are discussed. […] Mobilize research platforms for patient needs: Leverage our relationships with participants and rapidly deploy novel clinical engagement techniques such as digital tools to intervene remotely and reduce the negative effects of social isolation on our participants. […] Above all, clinical researchers need to continue working, to help as many people as possible through the crisis. | 2020-04-03 |
| 32207591 | To analyze the CT findings of patients with different clinical types of coronavirus disease 2019 (COVID-19). […] A total of 67 patients diagnosed as COVID-19 by nucleic acid testing were included and divided into 4 groups according to the clinical staging based on Diagnosis and treatment of novel coronavirus pneumonia (Trial version 6). […] The CT imaging characteristics were analyzed among patients with different clinical types. […] CT images in patients with different clinical types of COVID-19 have characteristic manifestations, and solid shadow may predict severe and critical illness. | 2020-03-26 |
| 32208140 | The team formulated various measures: reconfiguration of the radiology department, personal protection and training of staff, examination procedures for patients suspected of or confirmed with COVID-19 as well as patients without an exposure history or symptoms. | 2020-04-13 |
| 32208481 | To describe the implementation of technological support important for optimizing clinical management of the COVID-19 pandemic. […] An Incident Command Center was established early in the crisis and helped identify electronic health record (EHR) based tools to support clinical care. […] We outline the design and implementation of EHR based rapid screening processes, laboratory testing, clinical decision support, reporting tools, and patient-facing technology related to COVID-19. […] The EHR is an essential tool in supporting the clinical needs of a health system managing the COVID-19 pandemic. | 2020-03-25 |
| 32208840 | He depicts the clinical course of SARS-CoV-2 infection. […] Professor Hongzhou Lu, a leader in China to try various anti-viral drugs, expresses concern on the quality of the ongoing clinical trials as most trials are small in scale and repetitive in nature, and emphasizes the importance of the quick publication of clinical trial results. […] Professor Wenhong Zhang is responsible for Shanghai’s overall clinical management of the COVID-19 cases. | 2020-04-07 |
| 32208917 | This study aims to analyze the different clinical characteristics between children and their families infected with severe acute respiratory syndrome coronavirus 2. […] Clinical data from nine children and their 14 families were collected, including general status, clinical, laboratory test, and imaging characteristics. […] Three children had fever (22.2%) or cough (11.2%) symptoms and six (66.7%) children had no symptom. […] Among the 14 adult patients, the major symptoms included fever (57.1%), cough (35.7%), chest tightness/pain (21.4%), fatigue (21.4%) and sore throat (7.1%). […] COVID-19 in children is mainly caused by family transmission, and their symptoms are mild and prognosis is better than adult. […] Because of the mild or asymptomatic clinical process, it is difficult to recognize early for pediatrician and public health staff. | 2020-04-07 |
| 32209163 | We describe the clinical picture and laboratory findings 3-23 days since the first symptoms. | 2020-04-02 |
| 32209890 | This study is performed to analyze the clinical characteristics of patients who succumbed to and who recovered from 2019 novel coronavirus disease (COVID-19). […] Clinical data were collected from two tertiary hospitals in Wuhan. […] A retrospective investigation was conducted to analyze the clinical characteristics of fatal cases of COVID-19 (death group) and compare them with recovered patients (recovered group). […] On admission, the proportion of patients with symptoms of dyspnea (70.6% vs. | 2020-03-26 |
| 32210236 | All data are geo-coded and, where available, include symptoms, key dates (date of onset, admission, and confirmation), and travel history. | 2020-04-01 |
| 32211755 | Rapid identification of COVID-19 cases, which is crucial to outbreak containment efforts, is challenging due to the lack of pathognomonic symptoms and in settings with limited capacity for specialized nucleic acid-based reverse transcription polymerase chain reaction (PCR) testing. […] Demographic, clinical, laboratory and exposure-risk variables ascertainable at presentation were analyzed to develop an algorithm for estimating the risk of COVID-19. […] Using leave-out-one cross validation, all the models incorporating clinical tests (Models 1, 2 and 3) performed well with areas under the receiver operating characteristics curve (AUC) of 0.91, 0.88 and 0.88 respectively. […] Rapidly ascertainable clinical and laboratory data could identify individuals at high risk of COVID-19 and enable prioritization of PCR-testing and containment efforts. | 2020-03-26 |
| 32211765 | Fever, chills, cough, shortness of breath, generalized myalgia, malaise, drowsy, diarrhoea, confusion, dyspnoea, and bilateral interstitial pneumonia are the common symptoms. | 2020-03-26 |
| 32211816 | Clinical laboratory, radiological, and treatment data were collected and analyzed. […] Common symptoms included fever (334 patients [80.3%]), cough (144 [34.6%]), and shortness of breath (117 [28.1%]). | 2020-03-28 |
| 32211844 | This study aimed to investigate the epidemiological and clinical characteristics of older patients with COVID-19 out of Wuhan. […] A retrospective study was performed, with collecting data from medical records of confirmed COVID-19 patients in Zhejiang province from Jan 17 to Feb 12, 2020. […] Epidemiological, clinical and treatment data were analyzed between those older (≥60y) and younger (<60y) patients. […] The specific epidemiological and clinical features of older COVID-19 patients included significantly higher female gender, body temperature, co-existing of basic diseases and rate of severe and critical type. | 2020-03-26 |
| 32211920 | Unlike other acute infectious diseases progressing to sepsis, the severe courses of COVID19 seemingly show prolonged progression from onset of first symptoms to life-threatening deterioration of (primarily) lung function. | 2020-03-26 |
| 32211963 | Patients were assigned to the early-stage group (onset of symptoms within 4 days) or progressive-stage group (onset of symptoms within 4-7 days) for analysis. | 2020-03-30 |
| 32212059 | We summarized the effective intervention and prevention measures in the fields of public health response, clinical management, and research development in China, which may provide vital lessons for the global response. | 2020-03-26 |
| 32212920 | The conduct of clinical trials during the West Africa Ebola outbreak in 2014 highlighted many ethical challenges. […] How these challenges were addressed, what clinical studies were conducted during that outbreak, and the lessons learned for dealing with future outbreaks were the subject of a National Academy of Medicine committee report titled Integrating Clinical Research into Epidemic Response: The Ebola Experience. […] We also discuss the current Ebola outbreak in the Democratic Republic of the Congo and highlight how the dialogue has changed and how successful clinical trials have been implemented. | 2020-03-28 |
| 32213260 | Clinical trials are needed to guide treatment decisions. | 2020-03-27 |
| 32213556 | Previous studies mainly focused on Wuhan and typical symptoms. […] We analysed 74 confirmed COVID-19 cases with GI symptoms in the Zhejiang province to determine epidemiological, clinical and virological characteristics. […] Epidemiological, demographic, clinical, laboratory, management and outcome data of patients with GI symptoms were analysed using multivariate analysis for risk of severe/critical type. […] Of patients with COVID-19 with GI symptoms, 17 (22.97%) and 23 (31.08%) had severe/critical types and family clustering, respectively, significantly higher than those without GI symptoms, 47 (8.14%) and 118 (20.45%). […] Of patients with COVID-19 with GI symptoms, 29 (39.19%), 23 (31.08%), 8 (10.81%) and 16 (21.62%) had significantly higher rates of fever >38.5°C, fatigue, shortness of breath and headache, respectively. […] We report COVID-19 cases with GI symptoms with novel features outside Wuhan. […] Attention to patients with COVID-19 with non-classic symptoms should increase to protect health providers. | 2020-04-08 |
| 32213647 | Major behavioral, clinical, and state interventions have been undertaken to mitigate the epidemic and prevent the persistence of the virus in human populations in China and worldwide. | 2020-03-27 |
| 32213700 | This brief contribution aims to offer a reflection on the public and clinical role of the bioethicist: a figure able to promote dialogue between the world of medicine and the community, and to face ethical dilemmas even in emergent clinical settings. | 2020-04-02 |
| 32213786 | Prenatal clinics should ensure all pregnant women and their visitors are screened for fever and respiratory symptoms, and symptomatic women should be isolated from well women and required to wear a mask. | 2020-04-16 |
| 32214286 | The clinical spectrum of COVID-19 varies from asymptomatic forms to conditions encompassing multiorgan and systemic manifestations in terms of septic shock, and multiple organ dysfunction (MOD) syndromes. […] In this manuscript, we describe the urgent need for various solutions, pathogenesis of coronavirus and the clinical evidence for treatment of COVID-19 with stem cells. | 2020-04-01 |
| 32215613 | With conflicting mechanistic evidence, we propose key clinical research priorities necessary to clarify the role of RAS inhibition in COVID-19 mortality that could be rapidly addressed by the international research community. | 2020-04-14 |
| 32215622 | Maximal clinical signs of rapid breathing, weight loss, histopathological changes from the initial exudative phase of diffuse alveolar damage with extensive apoptosis to the later proliferative phase of tissue repair, airway and intestinal involvement with virus nucleocapsid protein expression, high lung viral load, and spleen and lymphoid atrophy associated with marked cytokine activation were observed within the first week of virus challenge. | 2020-03-27 |
| 32215691 | To explore the relationship between the imaging manifestations and clinical classification of COVID-19. […] Patients were divided into 3 types based on Chinese guideline: mild (patients with minimal symptoms and negative CT findings), common, and severe-critical (patients with positive CT findings and different extent of clinical manifestations). […] The TSS was compared with the clinical classification. […] The proportion of clinical mild-type patients with COVID-19 was relatively high; CT was not suitable for independent screening tool. […] The CT visual quantitative analysis has high consistency and can reflect the clinical classification of COVID-19. | 2020-03-30 |
| 32215760 | Over the years there have been numerous clinical and non-clinical reports of its broad spectrum of antiviral activity. | 2020-04-01 |
| 32215896 | We discuss the clinical management of all ENT patients, but especially of COVID-19 patients from the ENT perspective. | 2020-03-27 |
| 32215956 | While patients typically present with fever and a respiratory illness, some patients also report gastrointestinal symptoms such as diarrhoea, vomiting and abdominal pain. […] This has important implications to the disease management, transmission, and infection control. | 2020-03-27 |
| 32216009 | Clinical characteristics of 2019-nCoV that respiratory symptoms, such as cough, are the most common.[ | 2020-03-27 |
| 32216698 | Patients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, chronic obstructive pulmonary disease, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons. | 2020-04-10 |
| 32216803 | We sought to analyse the clinical characteristics and laboratory findings of some cases with 2019 novel coronavirus pneumonia . | 2020-04-01 |
| 32216961 | To report the epidemiological, clinical, and radiological characteristics of patients with COVID-19 in Xiaogan, Hubei, China. […] The complete clinical and imaging data of 114 confirmed COVID-19 patients treated in Xiaogan Hospital were analysed retrospectively. | 2020-04-10 |
| 32217113 | The SARS-CoV-2 virus has been isolated from asymptomatic individuals, and affected patients continue to be infectious two weeks after cessation of symptoms. […] Our clinical service model is built around the principles of workplace segregation, responsible social distancing, containment of cross-infection to healthcare providers, judicious use of personal protective equipment and telemedicine. | 2020-03-28 |
| 32217117 | Based on clinical features, pathology, the pathogenesis of acute respiratory disorder induced by either highly homogenous coronaviruses or other pathogens, the evidence suggests that excessive inflammation, oxidation, and an exaggerated immune response very likely contribute to COVID-19 pathology. […] Melatonin is effective in critical care patients by reducing vessel permeability, anxiety, sedation use, and improving sleeping quality, which might also be beneficial for better clinical outcomes for COVID-19 patients. […] Additional experiments and clinical studies are required to confirm this speculation. | 2020-04-16 |
| 32217556 | To delineate the clinical characteristics of patients with coronavirus disease 2019 (covid-19) who died. […] Clinical characteristics and laboratory findings were obtained from electronic medical records with data collection forms. | 2020-04-06 |
| 32217650 | Among laboratory-confirmed cases of Covid-19, patients with any comorbidity yielded poorer clinical outcomes than those without. […] A greater number of comorbidities also correlated with poorer clinical outcomes. | 2020-03-31 |
| 32217834 | In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. | 2020-04-13 |
| 32217835 | METHODSIn this retrospective study, the clinical and immunological characteristics of 21 patients (17 male and 4 female) with COVID-19 were analyzed. […] Common clinical manifestations included fever, cough, and fatigue. | 2020-04-13 |
| 32217900 | We present clinical and chest computed tomography (CT) features of 5 cases of pediatric patients with 2019 novel coronavirus. | 2020-03-28 |
| 32218915 | Hereby, we show our recommendations for the management of COVID-19 patients, based on very limited clinical evidences; they should be considered as expert opinions, which may be modified according to newly produced literature data. | 2020-03-31 |
| 32219006 | The confirmation rate of Wuhan estimated by our model is 0.0643, substantially lower than that of Hubei excluding Wuhan (0.1914), and that of China excluding Hubei (0.2189), but it jumps to 0.3229 after February 12 when clinical evidence was adopted in new diagnosis guidelines. | 2020-03-31 |
| 32219357 | To describe the presentation of acute myocardial inflammation in a patient with coronavirus disease 2019 (COVID-19) who recovered from the influenzalike syndrome and developed fatigue and signs and symptoms of heart failure a week after upper respiratory tract symptoms. […] The patient did not show any respiratory involvement during the clinical course. […] She was treated with dobutamine, antiviral drugs (lopinavir/ritonavir), steroids, chloroquine, and medical treatment for heart failure, with progressive clinical and instrumental stabilization. […] This case highlights cardiac involvement as a complication associated with COVID-19, even without symptoms and signs of interstitial pneumonia. | 2020-03-28 |
| 32219428 | Clinical outcomes were compared before and after convalescent plasma transfusion. […] In this preliminary uncontrolled case series of 5 critically ill patients with COVID-19 and ARDS, administration of convalescent plasma containing neutralizing antibody was followed by improvement in their clinical status. […] The limited sample size and study design preclude a definitive statement about the potential effectiveness of this treatment, and these observations require evaluation in clinical trials. | 2020-03-31 |
| 32219626 | Based on the New Diagnosis and Treatment Scheme for Novel Coronavirus Infected Pneumonia (Trial Edition 5), combined with our current clinical treatment experience, we recently proposed a revision of the first edition of “Guidance for maternal and fetal management during pneumonia epidemics of novel coronavirus infection in the Wuhan Tongji Hospital”. | 2020-03-28 |
| 32219814 | Patients with central nervous system involvement may show a series of neurological symptoms, which is easy to be misdiagnosed and neglected, thereby increasing the risk of SARS-CoV-2 transmission. […] Hereditary ataxia is a large group of neurodegenerative diseases with great clinical and genetic heterogeneity and high mortality and disability. | 2020-04-02 |
| 32219885 | Our results indicate that in addition to the emphasis on RT-PCR testing, clinical indicators such as computed tomography images should also be used not only for diagnosis and treatment but also for isolation, recovery/discharge, and transferring for hospitalized patients clinically diagnosed with COVID-19 during the current epidemic. | 2020-04-05 |
| 32220033 | To assess the factors associated with severity and prognosis of patients infected with SARS-CoV-2, we retrospectively investigated the clinical, imaging, and laboratory characteristics of confirmed 280 cases of novel coronavirus disease (COVID-19) from January 20 to February 20, 2020. | 2020-03-28 |
| 32220177 | The main clinical symptoms of the patients are fever and cough, accompanied with leukocytopenia and lymphocytopenia. | 2020-04-02 |
| 32220180 | If non-emergency oral situation occur, parents could assist their child to take home based care such as rinsing to relieve the symptoms. | 2020-04-02 |
| 32220181 | We studied the epidemiological and clinical data collected from a family with 5 people, in which there were 3 family member diagnosed as coronavirus disease 2019 (COVID-19). […] The most common symptoms were fever, cough and weakness. […] The epidemiological and clinical features could provide quicker diagnosis and better management for the COVID-19 infected patients. | 2020-04-02 |
| 32220208 | Most cases among residents included respiratory illness consistent with Covid-19; however, in 7 residents no symptoms were documented. | 2020-04-07 |
| 32220276 | Objective: To investigate the clinical and coagulation characteristics of the critical Coronavirus disease 2019 (COVID-19) patients with acro-ischemia in the intensive care unit (ICU). Methods: The retrospective study included 7 critical COVID-19 patients with acro-ischemia in a single center in Wuhan, from Feb 4 to Feb 15, 2020. […] The clinical and laboratory data before and during the ICU stay were analyzed. Results: The median age of 7 patients was 59 years and 4 of them were men. 3 of them were associated with underlying comorbidities. […] Fever, cough, dyspnea and diarrhea were common clinical symptoms. […] D-dimer and FDP levels increased progressively when COVID-2019 exacerbated, and 4 patients were diagnosed with definite disseminated intravascular coagulation (DIC). 6 patients received low molecular weight heparin (LMWH) treatment, after which their D-dimer and FDP decreased, but there was no significant improvement in clinical symptoms. 5 patients died finally and the median time from acro-ischemia to death was 12 days. Conclusions: The existence of hypercoagulation status in critical COVID-2019 patients should be monitored closely, and anticoagulation therapy can be considered in selected patients. […] More clinical data is needed to investigate the role of anticoagulation in COVID-2019 treatment. 目的： 总结合并肢端缺血的新型冠状病毒肺炎（COVID-19）患者的临床和凝血参数特征。 | 2020-03-29 |
| 32220284 | The number of affected pregnant women is increasing, but scarce information is available about the clinical features of COVID-19 in pregnancy. […] This study aimed to clarify the clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19. […] Clinical features, treatments, and maternal and fetal outcomes were assessed. […] Clinical manifestations were fever (six [86%] patients), cough (one [14%] patient), shortness of breath (one [14%] patient), and diarrhoea (one [14%] patient). […] All the patients had caesarean section within 3 days of clinical presentation with an average gestational age of 39 weeks plus 2 days. […] The clinical characteristics of these patients with COVID-19 during pregnancy were similar to those of non-pregnant adults with COVID-19 that have been reported in the literature. | 2020-04-16 |
| 32220557 | The purpose of the present report is to summarize current knowledge and experiences on anesthetic management in this patient population and to provide clinical practice guidelines on anesthetic management and infection prevention and control in these critically ill patients. | 2020-04-01 |
| 32220574 | We retrospectively analyzed the clinical presentations, laboratory data, radiologic findings, and travel and exposure contact histories, of the COVID-19 patients in comparison to those with other respiratory infections. […] Since all patients shared similar clinical and laboratory findings, expanded surveillance of detailed exposure history for suspected patients and application of rapid detection tools are highly recommended. | 2020-04-01 |
| 32220650 | Little is known about the epidemiological and clinical features of paediatric patients with COVID-19. […] We retrospectively retrieved data for paediatric patients (aged 0-16 years) with confirmed COVID-19 from electronic medical records in three hospitals in Zhejiang, China. […] We recorded patients’ epidemiological and clinical features. […] The route of transmission was by close contact with family members (32 [89%]) or a history of exposure to the epidemic area (12 [33%]); eight (22%) patients had both exposures. 19 (53%) patients had moderate clinical type with pneumonia; 17 (47%) had mild clinical type and either were asymptomatic (ten [28%]) or had acute upper respiratory symptoms (seven [19%]). […] Common symptoms on admission were fever (13 [36%]) and dry cough (seven [19%]). […] Ningbo Clinical Research Center for Children’s Health and Diseases, Ningbo Reproductive Medicine Centre, and Key Scientific and Technological Innovation Projects of Wenzhou. | 2020-04-16 |
| 32221519 | The antibody response in infected patient remains largely unknown, and the clinical values of antibody testing have not been fully demonstrated. […] Moreover, a higher titer of Ab was independently associated with a worse clinical classification (p=0.006). […] The antibody detection offers vital clinical information during the course of SARS-CoV-2 infection. | 2020-03-29 |
| 32221523 | The widely used reverse transcription PCR (RT-PCR) method has limitations for clinical diagnosis and treatment. […] Clinical and imaging data were obtained for clinical staging. | 2020-03-29 |
| 32221964 | We recommend that staff working in clinical areas expected to receive patients with COVID-19 conduct in-situ simulation in order to detect their own unique risks and aid in the creation of local guidelines of management of patients with COVID-19. | 2020-03-31 |
| 32221973 | Clinical data from the Chinese outbreak have been reported, but experiences and recommendations from clinical practice during the Italian outbreak have not. […] We also report on recommendations based on clinical experiences of managing patients throughout Italy. […] In particular, we describe key elements of clinical management, including: safe oxygen therapy; airway management; personal protective equipment; and non-technical aspects of caring for patients diagnosed with coronavirus disease 2019. | 2020-04-01 |
| 32221983 | Acute respiratory distress syndrome (ARDS) is a clinical high-mortality disease, and ACE2 has a protective effect on this type of acute lung injury. | 2020-04-05 |
| 32222119 | The aim is to evaluate pregnant women infected with coronavirus disease 2019 (COVID-19) and provide help for clinical prevention and treatment. […] Their primary initial manifestations were merely low-grade postpartum fever or mild respiratory symptoms. | 2020-04-10 |
| 32222121 | The management and clinical outcome of a sigmoid cancer patient with COVID-19 were analyzed. | 2020-04-01 |
| 32222122 | To investigate the clinical outcome of patients with moderate type of corona virus disease 2019 (COVID-19) after discharge by retesting viral nucleic acid. […] During the three weeks of quarantined period, the symptoms and signs were documented; and sputum or nasal swab and feces samples were collected to test SARS-COV-2 nucleic acid by RT-PCR method. […] There were no symptoms and signs during the quarantine period in all 7 patients. | 2020-04-01 |
| 32222466 | In the past two months, we clinical immunologists participated in multi-rounds of MDT (multidiscipline team) discussion on the anti-inflammation management of critical COVID-19 patients, with our colleagues dispatched from Chinese leading PUMC Hospital to Wuhan to admit and treat the most severe patients. […] Here, from the perspective of clinical immunologists, we will discuss the clinical and immunological characteristics of severe patients, and summarize the current evidence and share our experience in anti-inflammation treatment, including glucocorticoids, IL-6 antagonist, JAK inhibitors and choloroquine/hydrocholoroquine, of patients with severe COVID-19 that may have an impaired immune system. | 2020-04-16 |
| 32222703 | With the control of uremia and fluid status, this patient ended up with an uneventful post-CRRT course, absence of clinical symptoms, and negative PCR tests. | 2020-03-30 |
| 32222713 | During this interval, he reported nausea, vomiting, diarrhea, and low-grade fevers but was not suspected of COVID-19 infection until he developed respiratory symptoms and was admitted to the hospital. | 2020-03-30 |
| 32222720 | Coronavirus disease 2019 (COVID-19) outbreak started in December 2019 that caused difficulties for clinical work. | 2020-04-07 |
| 32222911 | Chinese pharmacists have acted swiftly in the public health response in China, such as drafting professional service guidance to pharmacists and pharmacies, establishing emergency drug formularies, monitoring and resolving drug shortages, establishing remote pharmacy services to prevent human-to-human infections, providing event-driven pharmaceutical care, educating the public on infection prevention and disease management, and participating in clinical trials and drug evaluation. | 2020-04-02 |
| 32222986 | Clinical and epidemiological characteristics were compared between different groups by statistical method. […] Most of them were from other clinical departments (72.2%) rather than emergency department (3.7%) or medical technology departments (18.5%). […] However, there was no statistical difference in terms of gender distribution and the first symptoms between theses two groups. | 2020-04-07 |
| 32222988 | We have reviewed gastrointestinal features of, and faecal test results in, COVID-19 from case reports and retrospective clinical studies relating to the digestive system published since the outbreak. […] With an incidence of 3% (1/41)-79% (159/201), gastrointestinal symptoms of COVID-19 included anorexia 39.9% (55/138)-50.2% (101/201), diarrhoea 2% (2/99)-49.5% (146/295), vomiting 3.6% (5/138)-66.7% (4/6), nausea 1% (1/99)-29.4% (59/201), abdominal pain 2.2% (3/138)-6.0% (12/201) and gastrointestinal bleeding 4% (2/52)-13.7% (10/73). […] Adult and children patients can present with digestive symptoms in the absence of respiratory symptoms. […] The incidence of digestive manifestations was higher in the later than in the early stage of the epidemic, but no differences in digestive symptoms among different regions were found. […] Among the group of patients with a higher proportion of severe cases, the proportion of gastrointestinal symptoms in severe patients was higher than that in nonsevere patients (anorexia 66.7% vs 30.4%; abdominal pain 8.3% vs 0%); while in the group of patients with a lower severe rate, the proportion with gastrointestinal symptoms was similar in severe and nonsevere cases (nausea and vomiting 6.9% vs 4.6%; diarrhoea 5.8% vs 3.5%). […] Gastrointestinal symptoms are common in patients with COVID-19, and had an increased prevalence in the later stage of the recent epidemic in China. | 2020-04-16 |
| 32223012 | Between 29 January 2020 and 24 February 2020, demographic, clinical, epidemiological and laboratory data were collected. […] We compared clinical features between patients not requiring admission for clinical reasons or antimicrobials with those assessed as needing either admission or antimicrobial treatment. […] Peaks of clinical assessments coincided with updates to the case definition for suspected COVID-19. […] Patients requiring admission on clinical grounds or antimicrobials (14/68) were more likely to have fever or raised respiratory rate compared to those not requiring admission or antimicrobials. […] The majority of patients had mild illness, which did not require clinical intervention. | 2020-04-08 |
| 32223871 | Data collected from patients who were tested included demographics, clinical characteristics, and test qualifying criteria. […] Symptoms-based criteria most associated with COVID-19 were the most common criteria identified for testing (90.6%). | 2020-04-01 |
| 32224074 | The aim of this study was to explore the different clinical presentations between COVID-19 and influenza A (H1N1) pneumonia in patients with ARDS. […] Their clinical manifestations, imaging characteristics, treatments, and prognosis were analyzed and compared. […] Patients with COVID-19 exhibited higher proportions of nonproductive coughs, fatigue, and GI symptoms than those of patients with H1N1 (P < .05). […] There were many differences in clinical presentations between patients with ARDS infected with either COVID-19 or H1N1. | 2020-04-14 |
| 32224133 | In the route have been considered three possible entrances depending on the needs of the users: anti-flu drugs, symptoms related to COVID-19 infection or the request for items for hygiene and prevention of transmission such as alcohol and face masks. | 2020-04-16 |
| 32224151 | To date, the clinical characteristics of COVID-19-infected cancer patients are largely unknown. […] The clinical data were collected from medical records from Jan 13, 2020, to Feb 26, 2020. […] The following clinical features were shown in our cohort: fever (23, 82.1%), dry cough (22, 81%) and dyspnoea (14, 50.0%), along with lymphopaenia (23, 82.1%), high level of high-sensitivity C-reactive protein (23, 82.1%), anaemia (21, 75.0%) and hypoproteinaemia (25, 89.3%). | 2020-03-31 |
| 32224310 | We assessed patterns of clinical disease and viral load from different samples (nasopharyngeal and blood, urine, and stool samples), which were obtained once daily for 3 days from hospital admission, and once every 2 or 3 days until patient discharge. […] Three different clinical evolutions are described: (1) two paucisymptomatic women diagnosed within a day of exhibiting symptoms, with high nasopharyngeal titres of SARS-CoV-2 within the first 24 h of the illness onset (5·2 and 7·4 log10 copies per 1000 cells, respectively) and viral RNA detection in stools; (2) a two-step disease progression in two young men, with a secondary worsening around 10 days after disease onset despite a decreasing viral load in nasopharyngeal samples; and (3) an 80-year-old man with a rapid evolution towards multiple organ failure and a persistent high viral load in lower and upper respiratory tract with systemic virus dissemination and virus detection in plasma. […] We illustrated three different clinical and biological types of evolution in five patients infected with SARS-CoV-2 with detailed and comprehensive viral sampling strategy. | 2020-04-16 |
| 32225135 | The public health emergency caused by the Coronavirus Disease 2019 (COVID-19) pandemic has resulted in a significant reallocation of health resources with a consequent reorganization of the clinical activities also in several urological centers. […] In absence of strict uniform regulations that impose the implementation of nasopharyngeal swabs, we recommend that an accurate triage for possible COVID-19 symptoms be performed both by telephone at home before hospitalization and at the time of hospitalization. | 2020-03-31 |
| 32226285 | In this review, we summarize the key events occurred during the early stage of SARS-CoV-2 outbreak, the basic characteristics of the pathogen, the signs and symptoms of the infected patients as well as the possible transmission pathways of the virus. | 2020-04-03 |
| 32226287 | In this study, we report clinical and microbiological features of ten COVID-19 patients enrolled in the Centro Hospitalar Conde de São Januário (CHCSJ) between January 21 to February 16, 2020. […] Clinical samples from all patients including nasopharyngeal swab (NPS)/sputum, urine, and feces were collected for serial virus RNA testing by standard qRT-PCR assay. […] The most common symptoms were fever (80%) and diarrhea (80%). | 2020-04-03 |
| 32226288 | The supportive care and non-specific treatment to ameliorate the symptoms of the patient are the only options currently. […] Due to the homology in epidemiology, genomics, and pathogenesis of the SARS-CoV-2 and SARS-CoV, and the widely use of TCM in the treatment of SARS-CoV, the clinical evidence showing the beneficial effect of TCM in the treatment of patients with SARS coronaviral infections are discussed. | 2020-04-03 |
| 32226289 | Herein, the host immune responses against SARS-CoV discussed in this review provide implications for developing NAbs and understanding clinical interventions against SARS-CoV-2. | 2020-04-03 |
| 32226294 | The knowledge questionnaire consisted of 12 questions regarding the clinical characteristics and prevention of COVID-19. | 2020-04-03 |
| 32226295 | Similar to its homologous virus, SARS-CoV, which caused SARS in thousands of people in 2003, SARS-CoV-2 might also be transmitted from the bats and causes similar symptoms through a similar mechanism. | 2020-04-03 |
| 32226353 | The present study developed the Fear of COVID-19 Scale (FCV-19S) to complement the clinical efforts in preventing the spread and treating of COVID-19 cases. | 2020-04-02 |
| 32226695 | The aim of this article is to outline a perspective on the pathophysiology of COVID-19 in the context of the currently available clinical data published in the literature. […] This article appreciates clinical data published on COVID-19 in the context of another respiratory illness - high altitude pulmonary edema (HAPE). | 2020-04-02 |
| 32226962 | While fever and respiratory symptoms have been commonly used to identify COVID-19 suspects, we present an elderly female who arrived to the hospital after a syncopal episode. | 2020-04-01 |
| 32227090 | The finding of this study explains the high rate of severe cases among COVID-19 patients with basic cardiovascular disease; and these results also perhaps provide important reference to clinical treatment of cardiac injury among severe patients infected by SARS-CoV-2. | 2020-03-31 |
| 32227091 | To retrospectively analyze the evolution of clinical features and thin-section CT imaging of novel coronavirus pneumonia (COVID-19) in 17 discharged patients. […] Longitudinal changes of clinical parameters and CT pattern were documented in all patients during 4 weeks since admission. […] The progression course of CT pattern was later than the clinical parameters within the first two weeks since admission; however, there was a synchronized improvement in both clinical and radiologic features in the 4th week. | 2020-03-31 |
| 32227123 | We aimed to clarify the characteristics and clinical significance of peripheral lymphocyte subset alteration in COVID-19. […] The levels of peripheral lymphocyte subsets were measured by flow cytometry in 60 hospitalized COVID-19 patients before and after treatment, and their association with clinical characteristics and treatment efficacy was analyzed. […] After treatment, 37 patients (67%) reached clinical response, with an increase of CD8+ T cells and B cells. […] Peripheral lymphocyte subset alteration was associated with the clinical characteristics and treatment efficacy of COVID-19. | 2020-03-31 |
| 32227274 | The clinical and laboratory findings were extracted from the electronic medical records of the patients. […] Information on clinical signs and symptoms, medical treatment, virus clearance, and laboratory parameters including interleukin 6 (IL-6) and C-reactive protein were collected. | 2020-03-31 |
| 32227357 | Clinical trials should also be undertaken to use statins, which are lipid-lowering drugs but have anti-inflammatory and immunomodulatory properties to prevent acute lung injury in COVID-19 infection. | 2020-03-31 |
| 32227758 | Clinical data were obtained through review of medical records. […] The mean (±SD) age of the patients was 64±18 years, 63% were men, and symptoms began 7±4 days before admission. […] The most common symptoms were cough and shortness of breath; 50% of patients had fever on admission, and 58% had diabetes mellitus. | 2020-04-16 |
| 32227819 | Furthermore, besides clinical activities, continuously important research projects were carried out in order to find new strategies and more effective therapies to better face an unprecedented health emergency in Italy. | 2020-04-01 |
| 32228222 | The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), are associated with clinical outcomes remains unknown. […] This evidence supports the benefit of using ACEIs or ARBs to potentially contribute to the improvement of clinical outcomes of COVID-19 patients with hypertension. | 2020-04-02 |
| 32228226 | The transcriptome dataset of COVID-19 patients would be a valuable resource for clinical guidance on anti-inflammatory medication and understanding the molecular mechansims of host response. | 2020-04-02 |
| 32228252 | In lieu of the fact that many older patients with hypertension or other CVDs are routinely treated with RAAS blockers and statins, new clinical concerns have developed regarding whether these patients are at greater risk for SARS-CoV-2 infection, whether RAAS and statin therapy should be discontinued, and the potential consequences of RAAS blockade to COVID-19-related pathologies such as acute and chronic respiratory disease. | 2020-04-16 |
| 32228732 | The epidemiological characteristics and clinical manifestations were analyzed. | 2020-04-16 |
| 32228809 | We report epidemiologic, laboratory, and clinical findings for 7 patients with 2019 novel coronavirus disease in a 2-family cluster. […] These findings might also serve as a practical reference for clinical diagnosis and medical treatment. | 2020-04-01 |
| 32228825 | The severity of the disease depends on the efficiency of the immune system which, if it is weak, cannot stem the infection and its symptoms. | 2020-04-01 |
| 32228827 | Future basic and clinical research is warranted to validate present results and hypothesis. 目的： 探讨冠状病毒感染所致心力衰竭（心衰）的机制，并预测对其可能有疗效的药物。 | 2020-04-01 |
| 32229107 | We report the dynamic change process of target genes by RT-PCR testing of SARS-Cov-2 during the course of a COVID-19 patient: from successive negative results to successive single positive nucleocapsid gene, to two positive target genes (orf1ab and nucleocapsid) by RT-PCR testing of SARS-Cov-2, and describe the diagnosis, clinical course, and management of the case. […] In this case, negative results of RT-PCR testing was not excluded to diagnose a suspected COVID-19 patient, clinical signs and symptoms, other laboratory findings, and chest CT images should be taken into account for the absence of enough positive evidence. | 2020-04-16 |
| 32229257 | We collected the medical records of 55 COVID-19 patients for analysis. […] At the end of the first two weeks after admission, clinical manifestations had completely despeared in 31(91.2%)patients in non-severe group, and 18(85.7%) patients in severe group (p=0.85). […] There were 45 cases were discharged from the hospital, and no patients died at the time of this clinical analysis. […] Risk-adapted treatment strategy was associated with significant clinical manifestations alleviation and clinical imaging recovery. | 2020-04-01 |
| 32229322 | For patients with a final confirmed diagnosis, clinical and laboratory data, in addition to CT imaging findings were evaluated. | 2020-04-16 |
| 32229390 | Results of correlation analysis indicated that economic effects, and effects on daily life, as well as delays in academic activities, were positively associated with anxiety symptoms (P < .001). | 2020-04-10 |
| 32229705 | This article also highlights a need for rigorous clinical validation of deep aging clocks as surrogate markers of biological age. […] This article does not represent medical advice and the medications described are not yet licensed or recommended as immune system boosters, as they have not undergone clinical evaluation for this purpose. | 2020-04-01 |
| 32229706 | Thus, we propose that new clinical trials may be warranted, as several senolytic and anti-aging therapeutics are existing FDA-approved drugs, with excellent safety profiles, and would be readily available for drug repurposing efforts. | 2020-04-01 |
| 32229732 | Whether the patients with coronavirus disease 19 (COVID-19) infected by severe acute respiratory syndrome (SARS)-CoV-2 would commonly develop acute kidney injury (AKI) is an important issue worthy of clinical attention. […] This study aimed to explore the effects of SARS-CoV-2 infection on renal function through analyzing the clinical data of 116 hospitalized COVID-19-confirmed patients. […] The recorded information includes demographic data, medical history, contact history, potential comorbidities, symptoms, signs, laboratory test results, chest computer tomography scans, and treatment measures. | 2020-04-01 |
| 32231171 | As the coronavirus disease 2019 (COVID-19) outbreak, identification of clinical predictors of severe or fatal disease are necessary to enable risk stratification and optimize allocation of limited resources. | 2020-04-01 |
| 32232217 | There has been no report of vertical transmission in pregnancy, and it has been found that clinical symptoms of COVID-19 in pregnant women are not different from those of non-pregnant women. | 2020-04-04 |
| 32232218 | All relevant articles that reported clinical characteristics and epidemiological information of hospitalized COVID-19 patients were included in the analysis. | 2020-04-04 |
| 32232230 | As one of the busiest specialised hospitals in the world, the Department of Oral and Maxillofacial Surgery of Peking University School and Hospital of Stomatology summarised the experience with disease prevention and control and clinical recommendations on the examination, diagnosis and treatment processes, clinical management, healthcare personnel protection and disinfection amid the continued spread of the pandemic. | 2020-04-02 |
| 32232432 | However, our current regulations on the flows of information for clinical care and research are antiquated and often conflict at the state and federal level. | 2020-04-01 |
| 32232433 | During the period of treatment, the ocular signs and symptoms as well as results of blood tests and reverse transcriptase-polymerase chain reaction (RT-PCR) from nasopharyngeal and conjunctival swabs for SARS-CoV-2 were noted and analyzed. […] Ocular signs and symptoms as well as results of blood tests and RT-PCR for SARS-CoV-2. […] By univariate analysis, patients with ocular symptoms were more likely to have higher white blood cell and neutrophil counts and higher levels of procalcitonin, C-reactive protein, and lactate dehydrogenase than patients without ocular symptoms. | 2020-04-04 |
| 32232648 | Chest CT would play a supplemental role to differentiate COVID-19 pneumonia from other respiratory diseases presenting with similar symptoms in a clinical setting. | 2020-04-01 |
| 32232652 | In this study, we analyzed clinical and transmission features of 25 cases of Covid-19 from a single thoracic department, including 13 patients and 12 health care staff. | 2020-04-01 |
| 32232977 | With the purpose of letting the public know the overall situation of the clinical trials of new coronary pneumonia in China as soon as possible, we completed the data collection and brief analysis in a very short time. | 2020-04-01 |
| 32233013 | Demographic data, medical history, symptoms and signs, laboratory findings, chest computed tomography (CT) as well the treatment measures were collected and analysed. | 2020-04-08 |
| 32233034 | Clinical departments that perform endoscopy are faced with daunting challenges during this pandemic. | 2020-04-01 |
| 32233641 | However, further clinical studies with large sample sizes are required to verify their effectiveness. | 2020-04-13 |
| 32233642 | The clinical, radiologic, and laboratory characteristics were retrospectively analyzed, and the factors associated with the disease progression were screened by binary logistic regression analysis. […] Fever (11/64.7%) and cough (8/47.1%) were the most common symptoms, whereas dyspnea (2/11.8%) and fatigue (3/17.6%) were rare, and there was no patient with diarrhea symptoms. […] There were no significant differences between the 2 groups with respect to their clinical characteristics. | 2020-04-13 |
| 32233719 | This outbreak is leading to additional health problems such as stress, anxiety, depressive symptoms, insomnia, denial, anger and fear globally. | 2020-04-02 |
| 32233816 | The clinical course of the disease in children and infants is milder than in adults. […] It should be noted that, although typical symptoms may be present in children, non-specific symptoms could be noted in the neonate. […] His mother had symptoms of Novel coronavirus. […] Eventually, the baby was discharged in good general condition.Conclusion: When a newborn presents with non-specific symptoms of infection with an added history of COVID-19 in his/her parents, it indicates the need for PCR testing for Novel coronavirus. | 2020-04-16 |
| 32233876 | We review the symptoms, epidemiology, and testing for this disease. | 2020-04-02 |
| 32233980 | Background and Purpose- Hyperacute assessment and management of patients with stroke, termed code stroke, is a time-sensitive and high-stakes clinical scenario. […] In the context of the current Coronavirus Disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2 virus, the ability to deliver timely and efficacious care must be balanced with the risk of infectious exposure to the clinical team. […] Furthermore, rapid and effective stroke care remains paramount to achieve maximal functional recovery for those needing admission and to triage care appropriately for those who may be presenting with neurological symptoms but have an alternative diagnosis. […] Methods- Available resources, COVID-19-specific infection prevention and control recommendations, and expert consensus were used to identify clinical screening criteria for patients and provide the required nuanced considerations for the healthcare team, thereby modifying the conventional code stroke processes to achieve a protected designation. […] Features specific to prenotification and clinical status of the patient were used to define precode screening. […] These include primary infectious symptoms, clinical, and examination features. | 2020-04-02 |
| 32234126 | We suggested that COVID-19 should be diagnosed as 3 types: suspected case, clinical diagnosed case, and definite diagnosed case. | 2020-04-02 |
| 32234127 | Objective: To understand the epidemiological characteristics of COVID-19 cases in different epidemic stages in Gansu province. Methods: Epidemiological investigation was conducted to collect the information of confirmed COVID-19 cases, including demographic, epidemiological and clinical information. Results: As of 25 February 2020, a total of 91 confirmed COVID-19 cases had been reported in Gansu. […] The initial symptoms included fever (54.95%, 50/91), cough (52.75%, 48/91), or fatigue (28.57%, 26/91), the proportion of each symptom showed a decreasing trend along with the three epidemic stages, but only the differences in proportions of fever (trend χ2=2.20, P<0.05) and fatigue (trend χ2=3.18, P<0.05) among the three epidemic stages were statistically significant. […] The cases with critical severe symptoms accounted for 42.85% (6/14), 23.73% (14/59) and 16.67% (3/18), respectively, in three epidemic stages, showed a decreasing trend (H=6.45, P<0.05). | 2020-04-02 |
| 32234130 | As of March 2020, two 2019-nCoV vaccines have entered phase I clinical trials. | 2020-04-02 |
| 32234131 | Objective: To explore imaging characteristics of children with 2019 novel coronavirus (2019-nCoV) infection. Methods: A retrospective analysis was performed on clinical data and chest CT images of 15 children diagnosed with 2019-nCoV infection. […] The clinical symptoms of children with 2019-nCoV infection are nonspecific. | 2020-04-03 |
| 32234250 | Here, we report the clinical characteristics and outcomes for both patients with COVID-19 and the anaesthetists who provided their spinal anaesthesia. […] Clinical characteristics and perioperative outcomes were recorded. […] For anaesthesiologists exposed to patients with COVID-19 by providing spinal anaesthesia, the level of personal protective equipment (PPE) used, clinical outcomes (pulmonary CT scans), and confirmed COVID-19 transmission rates (polymerase chain reaction [PCR]) were reviewed. | 2020-04-02 |
| 32234451 | Although related to the Severe Acute Respiratory Syndrome (SARS) and the Middle East Respiratory Syndrome (MERS), COVID-19 shows some peculiar pathogenetic, epidemiological and clinical features which have not been completely understood to date. […] We provide a review of the differences in terms of pathogenesis, epidemiology and clinical features between COVID-19, SARS and MERS. […] COVID-19 seems not to be very different from SARS regarding its clinical features. […] It cannot be excluded that because of the COVID-19 less severe clinical picture it can spread in the community more easily than MERS and SARS. | 2020-04-02 |
| 32234465 | Here we scrutinise a series of available studies by global scientists on the clinical manifestations, detection methods and treatment options for the disease caused by SARS-CoV-2, named coronavirus disease 2019 (COVID-19), and also propose potential strategies for preventing the infection. | 2020-04-15 |
| 32234467 | With the collation and publication of more and more clinical data, a large number of data suggest that there are mild or severe cytokine storms in severe patients, which is also an important cause of death. | 2020-04-09 |
| 32234728 | Every month, DTB scans sources of information on treatments, disease management and other healthcare topics for key items to bring to our readers’ attention and help them keep up to date. | 2020-04-02 |
| 32235387 | While most of the vaccines are under design and preparation, there are some that have entered efficacy evaluation in animals and initial clinical trials. | 2020-04-02 |
| 32235486 | We performed a scoping review of currently available clinical, epidemiological, laboratory, and chest imaging data related to the SARS-CoV-2 infection. […] Qualitative synthesis and meta-analysis were conducted using the clinical and laboratory data, and random-effects models were applied to estimate pooled results. […] The most common disease-related symptoms were fever (82%, 95% confidence interval (CI) 56%-99%; n = 4410), cough (61%, 95% CI 39%-81%; n = 3985), muscle aches and/or fatigue (36%, 95% CI 18%-55%; n = 3778), dyspnea (26%, 95% CI 12%-41%; n = 3700), headache in 12% (95% CI 4%-23%, n = 3598 patients), sore throat in 10% (95% CI 5%-17%, n = 1387) and gastrointestinal symptoms in 9% (95% CI 3%-17%, n = 1744). […] The majority of reported clinical symptoms and laboratory findings related to SARS-CoV-2 infection are non-specific. […] Clinical suspicion, accompanied by a relevant epidemiological history, should be followed by early imaging and virological assay. | 2020-04-02 |
| 32235945 | By causing an early onset of severe symptoms, this same receptor tropism is thought to have determined pathogenicity, but also aided the control, of severe acute respiratory syndrome (SARS) in 20035. […] However, there are reports of COVID-19 cases with mild upper respiratory tract symptoms, suggesting the potential for pre- or oligosymptomatic transmission6-8. […] Pharyngeal virus shedding was very high during the first week of symptoms (peak at 7.11 × 108 RNA copies per throat swab, day 4). […] Shedding of viral RNA from sputum outlasted the end of symptoms. | 2020-04-02 |
| 32236295 | In this regard, the high number of scientific publications, encompassing in vitro, case studies, observational and randomized clinical studies, and even systematic reviews add up to the uncertainty. | 2020-04-06 |
| 32236624 | In the present review, we address current knowledge on coronaviruses from a short history to epidemiology, pathogenesis, clinical manifestation of the disease, as well as treatment and prevention strategies. | 2020-04-02 |
| 32236983 | The range of clinical presentations varies from asymptomatic and mild clinical symptoms to acute respiratory-distress syndrome (ARDS) and death. […] However, the results of preliminary studies and clinical trials are improving our understanding of the pathogenesis and treatment of Covid-19. | 2020-04-02 |
| 32237161 | Knowledge about origin, symptoms, and spread of viral infection was assessed. | 2020-04-10 |
| 32237249 | Beginning of March, I worked in the emergency department and treated a patient with viral symptoms without a travel history who was admitted to the hospital. | 2020-04-02 |
| 32237278 | Clinical course and laboratory features of the first reported case of COVID-19 (the illness caused by SARS-CoV-2) in Australia; isolation, whole genome sequencing, imaging, and rapid sharing of virus from the patient. | 2020-04-05 |
| 32237288 | Korean Society for Laboratory Medicine and the Korea Centers for Disease Prevention and Control propose guidelines for diagnosing COVID-19 in clinical laboratories in Korea. | 2020-04-02 |
| 32238024 | A 35-year-old woman presented with fever and mild diarrhoea without any respiratory symptoms 9 days after travelling to Japan from Wuhan, China. […] A lower respiratory tract specimen should be obtained for better diagnosis of corona virus disease 2019, even in the absence of respiratory symptoms for patients with significant travel or exposure history. | 2020-04-16 |
| 32238223 | She presented to the hospital because of her concern, but she was without fever or any respiratory symptoms. | 2020-04-02 |
| 32238232 | Among the biological nature of the pathogens, viral receptor distribution on the human cells, and the pathological findings in the targeted organs and clinical features of the patients with the diseases, found similarities and differences between the two diseases. | 2020-04-02 |
| 32238358 | As the COVID-19 pandemic worsens, the clinical cancer community is grappling with how to continue providing access to experimental but potentially lifesaving therapies while keeping immunocompromised patients safe. […] To that end, cancer centers are making changes to their clinical trial programs, while pharmaceutical companies are deciding how-or whether-trials should continue. | 2020-04-02 |
| 32238429 | Infection with the novel coronavirus SARS-CoV-2 may remain asymptomatic, leading to under-recognition of the related disease, COVID-19, and to incidental findings in nuclear imaging procedures performed for standard clinical indications. […] Presence, radiological features and metabolic activity of interstitial pneumonia were identified, correlated with subsequent short-term clinical course and described in a case series. Results: Six of 65 patients (9%) that underwent PET/CT for various malignancies showed unexpected signs of interstitial pneumonia on CT and elevated regional FDG-avidity. | 2020-04-02 |
| 32238438 | Infected individuals report a range of symptoms from headaches to shortness of breath to taste and smell loss. | 2020-04-02 |
| 32238612 | Diagnosis involves a combination of clinical and epidemiological features with laboratory confirmation. | 2020-04-16 |
| 32238613 | The 2019-novel coronavirus predominantly affects the respiratory system with manifestations ranging from upper respiratory symptoms to full blown acute respiratory distress syndrome (ARDS). | 2020-04-16 |
| 32238615 | Perinatal period poses unique challenges and care of the mother-baby dyads requires special resources for prevention of transmission, diagnosis of infection and providing clinical care during labor, resuscitation and postnatal period. […] Existing guidelines, systematic reviews, clinical trials, narrative reviews and other descriptive reports were reviewed. […] To provide recommendations for prevention of transmission, diagnosis of infection and providing clinical care during labor, resuscitation and postnatal period. […] A set of twenty recommendations are provided under the following broad headings: 1) pregnant women with travel history, clinical suspicion or confirmed COVID-19 infection; 2) neonatal care; 3) prevention and infection control; 4) diagnosis; 5) general questions. | 2020-04-02 |
| 32239125 | However, studies and clinical trials in humans are required to know the result of their application in them. | 2020-04-04 |
| 32239127 | In this study, we investigate clinical and laboratory features and short-term outcomes of patients with Corona Virus Disease 2019(COVID-19). […] Epidemiological, clinical, radiological characteristics, underlying diseases, laboratory tests treatment, complications and outcomes data were collected. | 2020-04-02 |
| 32239142 | Clinical drugs targeting SARS-CoV-2 are urgently needed to decrease the high fatality rate of confirmed COVID-19 patients. […] Since the preclinical or clinical information of these identified drugs is already available, they might be ready for being clinically tested in the treatment of COVID-19. | 2020-04-02 |
| 32239525 | Orleans Parish in Louisiana is in the midst of an exponentially increasing number of patient admissions with COVID-19 and respiratory symptoms. […] Patients have been described having CT findings most consistent with an early-stage (<7 days from symptoms onset) or an advanced stage (8-14 days from symptoms onset). | 2020-04-13 |
| 32239532 | Use of LU has helped us in clinical decision making and reduced the use of both chest x-rays and computed tomography (CT). | 2020-04-15 |
| 32239591 | The clinical characteristics of patients with liver injury and without liver injury were compared. […] There were no significant differences in age, previous medical history and symptoms between the two groups. | 2020-04-13 |
| 32239761 | The clinical characteristics of novel coronavirus disease (COVID-2019) patients outside the epicenter of Hubei province are less understood. […] We analyzed the epidemiological and clinical features of all COVID-2019 cases in the only referral hospital in Shenzhen city, China from January 11, 2020 to February 6, 2020 and followed until March 6, 2020. | 2020-04-02 |
| 32239796 | The aim of our study was to investigate the changes of liver function and its clinical significance in COVID-19 patients. […] However, the clinical significance of the elevation is unremarkable. […] Although abnormalities of liver function indexes are common in COVID-19 patients, the impairment of liver function is not a prominent feature of COVID-19, and also may not have serious clinical consequences. | 2020-04-02 |
| 32240079 | One asymptomatic patient demonstrated virus shedding, indicating potential virus transmission in the absence of clinical signs and symptoms. | 2020-04-02 |
| 32240094 | Participants generally had good knowledge of the main mode of disease transmission and common symptoms of COVID-19. | 2020-04-09 |
| 32240095 | This extended surveillance comprises of five components: (1) Recording in medical records of anyone suspected to have or who has been exposed to COVID-19. […] Computerized medical records suppliers have within a week of request created new codes to support this. […] General practice clinical system providers have introduced an emergency new set of clinical codes to support COVID-19 surveillance. | 2020-04-09 |
| 32240128 | Residents were categorized as asymptomatic or symptomatic at the time of testing, based on the absence or presence of fever, cough, shortness of breath, or other symptoms on the day of testing or during the preceding 14 days. […] Among 23 (30%) residents with positive test results, 10 (43%) had symptoms on the date of testing, and 13 (57%) were asymptomatic. […] Seven days after testing, 10 of these 13 previously asymptomatic residents had developed symptoms and were recategorized as presymptomatic at the time of testing. […] The reverse transcription-polymerase chain reaction (RT-PCR) testing cycle threshold (Ct) values indicated large quantities of viral RNA in asymptomatic, presymptomatic, and symptomatic residents, suggesting the potential for transmission regardless of symptoms. | 2020-04-06 |
| 32240279 | A patient presenting with ISOA who went on to test positive for infection with COVID-19 and did not develop any further symptoms as well as a case series of similar patients although limited by the lack of reliable testing at the moment. | 2020-04-02 |
| 32240303 | Emergent policy changes related to telemedicine and the Emergency Medical Treatment and Labor Act (EMTALA) during the novel coronavirus pandemic (COVID-19) have created opportunities for technology-based clinical evaluation, which serves to conserve personal protective equipment (PPE) and protect emergency providers. | 2020-04-02 |
| 32240462 | The efficacy of some promising antivirals, convalescent plasma transfusion, and tocilizumab needs to be investigated by ongoing clinical trials. | 2020-04-02 |
| 32240545 | Careful clinical evaluation should allow to quickly establish whether such passive immunotherapy, administered at early phases of the disease in patients at high risk of deleterious evolution may reduce the frequency of patient deterioration, and thereby COVID-19 mortality. | 2020-04-02 |
| 32240567 | We believe that we need to adequately inform our patients, focusing on hygienic measures and personal protection and prompt reporting of any suspicious symptoms. | 2020-04-09 |
| 32240634 | These individual-case data were used to estimate the time between onset of symptoms and outcome (death or discharge from hospital). […] Using data on 24 deaths that occurred in mainland China and 165 recoveries outside of China, we estimated the mean duration from onset of symptoms to death to be 17·8 days (95% credible interval [CrI] 16·9-19·2) and to hospital discharge to be 24·7 days (22·9-28·1). | 2020-04-16 |
| 32240670 | Data of demographics, clinical features, comorbidities, laboratory tests and complications were collected and compared for different outcomes. […] Common symptoms included fever (92.0%), cough (53.0%), dyspnea (40.8%) and fatigue (39.9%). […] Symptoms of dyspnea (HR 2.35, P = 0.001), comorbidities including cardiovascular disease (HR 1.86, P = 0.031) and chronic obstructive pulmonary disease (HR 2.24, P = 0.023), and acute respiratory distress syndrome (HR 29.33, P < 0.001) were strong predictors of death. | 2020-04-14 |
| 32240718 | In this Case Report, we describe the clinical and epidemiological features of COVID-19 in 201 maintenance hemodialysis patients in Zhongnan Hospital of Wuhan university, including 5 maintenance hemodialysis patients who contracted COVID-19 disease. […] Diarrhea (80%), fever (60%), and fatigue (60%) were the most common symptoms. | 2020-04-04 |
| 32240754 | The strategy focuses on key content areas including identifying and addressing goals of care, addressing moderate and severe symptoms, and supporting family members. | 2020-04-02 |
| 32240756 | Within weeks, COVID-19 has transformed our practice of palliative care and clinical medicine as we know it. | 2020-04-02 |
| 32240896 | Our objective was to investigate the prevalence and predictors of posttraumatic stress symptoms (PTSS) in China hardest-hit areas during COVID-19 outbreak, especially exploring the gender difference existing in PTSS. | 2020-04-10 |
| 32241022 | Clinical records, laboratory results, and computer tomography(CT)-scan examination were retrospectively reviewed. […] The clinical characteristics of these ten women were similar to those reported severe COVID-19 patients. | 2020-04-02 |
| 32241056 | Secondly, the clinical features, CT imaging, short-term and long-term pulmonary function damage of the 2019 coronavirus disease (COVID-19) was analyzed. […] Finally, some suggestions for thoracic surgery clinical practice in non-epidemic area during and after the epidemic of COVID-19 were provided, to help all the thoracic surgery patients receive active and effective treatment. | 2020-04-03 |
| 32241072 | Severe acute respiratory syndrome (SARS) and coronavirus disease 2019 (COVID-19) shared similar pathogenetic, clinical and pathological features. […] Fever and cough were the most common symptoms of both diseases, while myalgia and diarrhea were less common in patients with COVID-19. | 2020-04-03 |
| 32241244 | To date, computed tomography (CT) findings have been recommended as major evidence for the clinical diagnosis of COVID-19 in Hubei, China. […] Since most patients with COVID-19 infection share typical imaging features, radiological examinations have an irreplaceable role in screening, diagnosis and monitoring treatment effects in clinical practice. | 2020-04-03 |
| 32241316 | Based on the analysis of the cases of 4 patients, this article finds that early diagnosis requires a combination of epidemiology, clinical manifestations, imaging, and etiology, with particular emphasis on epidemiology history and chest CT manifestations. | 2020-04-03 |
| 32241899 | To study the GI symptoms in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. […] We analysed epidemiological, demographic, clinical and laboratory data of 95 cases with SARS-CoV-2 caused coronavirus disease 2019. […] Among the 95 patients, 58 cases exhibited GI symptoms of which 11 (11.6%) occurred on admission and 47 (49.5%) developed during hospitalisation. […] Diarrhoea (24.2%), anorexia (17.9%) and nausea (17.9%) were the main symptoms with five (5.3%), five (5.3%) and three (3.2%) cases occurred on the illness onset, respectively. […] Faecal samples of 65 hospitalised patients were tested for the presence of SARS-CoV-2, including 42 with and 23 without GI symptoms, of which 22 (52.4%) and 9 (39.1%) were positive, respectively. […] Six patients with GI symptoms were subjected to endoscopy, revealing oesophageal bleeding with erosions and ulcers in one severe patient. | 2020-04-03 |
| 32242182 | We recommend that patients on such medications should continue on them unless there is a clinical indication to stop their use. | 2020-04-09 |
| 32242348 | In this retrospective multicenter study, we investigated the clinical course and outcomes of novel coronavirus disease 2019 (COVID-19) from early cases in Republic of Korea. […] Clinical data were collected and analyzed for changes in clinical severity including laboratory, radiological, and virologic dynamics during the progression of illness. […] The most common symptoms were cough (28.6%) and sore throat (28.6%), followed by fever (25.0%). […] Two patients had no symptoms. […] The prodromal symptoms of COVID-19 were mild and most patients did not have limitations of daily activity. | 2020-04-06 |
| 32242438 | The most common symptoms are fever, cough and shortness of breath. | 2020-04-08 |
| 32242738 | To report the clinical features of 85 fatal cases with COVID-19 in two hospitals in Wuhan. […] Medical records of 85 fatal cases of COVID-19 between January 9 and February 15, 2020 were collected. […] Information recorded included medical history, exposure history, comorbidities, symptoms, laboratory findings, CT scans and clinical management. […] Common symptoms were fever (78 [91.8%]), shortness of breath (50 [58.8%]), fatigue (50 [58.8%]), dyspnea (60 [70.6%]). | 2020-04-03 |
| 32242830 | As patients need to be treated and tested, it is important to develop a clinical laboratory in the modular hospital and ensure biosafety. […] The construction of a clinical laboratory in the modular hospital is faced with problems such as time pressure, limited site selection, high level of biosafety, lack of experience and so forth. […] This paper mainly discusses how to construct the clinical laboratory in the modular hospital quickly and safely and put it into use to provide testing service for patients under various limited conditions. | 2020-04-03 |
| 32242947 | We aim to explore reliable evidence for the diagnosis and treatment of the COVID-19 by analyzing all the published studies by Chinese scholars on the clinical and imaging features in novel coronavirus pneumonia caused by SARS-CoV-2. […] A random-effects model was designed, and the imaging and clinical data from all studies were collected for meta-analysis. […] The results of meta-analysis showed that the most common clinical manifestations were fever (87.3%; 0.838-0.909), cough (58.1%; 0.502-0.660), dyspnea (38.3%; 0.246-0.520), muscle soreness or fatigue (35.5%; 0.253-0.456), and chest distress (31.2%; -0.024 to 0.648). […] COVID-19 is a new clinical infectious disease that mainly causes bilateral pneumonia and lung function deteriorates rapidly. | 2020-04-10 |
| 32243068 | We recognize that this guidance might be subject to change in the future when further knowledge will be acquired about the COVID-19 pandemic, the perinatal transmission of SARS-CoV-2 and clinical characteristics of cases of neonatal COVID-19. | 2020-04-03 |
| 32243238 | Methods In this prospective study from March 4, 2020, until March 19, 2020, consecutive patients with suspected COVID-19 infection and respiratory symptoms were enrolled. | 2020-04-03 |
| 32243266 | In conclusion, ensuring effective, timely, and safe ECMO support in COVID-19 is key to improving clinical outcomes. | 2020-04-06 |
| 32243269 | Besides typical respiratory symptoms and signs of COVID-19, digestive symptoms and liver injury have been frequently reported during the course of the disease. […] Digestive symptoms, including anorexia, nausea, vomiting and diarrhea, are not uncommon in patients with COVID-19, and in some cases digestive symptoms may occur in the absence of any respiratory symptoms. | 2020-04-03 |
| 32243270 | More clinical trials are being conducted for further confirmation of the efficacy and safety of these agents in treating COVID-19. | 2020-04-03 |
| 32243304 | Studies of the novel coronavirus-induced disease COVID-19 in Wuhan, China, have elucidated the epidemiological and clinical characteristics of this disease in the general population. […] The present investigation summarizes the clinical characteristics and early prognosis of COVID-19 infection in a cohort of patients with fractures. […] Analyses of early prognosis were based on clinical outcomes and trends in laboratory results during treatment. […] The clinical outcomes for the surviving patients are not yet determined. […] The clinical characteristics and early prognosis of COVID-19 in patients with fracture tended to be more severe than those reported for adult patients with COVID-19 without fracture. […] This finding may be related to the duration between the development of symptoms and presentation. | 2020-04-03 |
| 32243599 | A well-mixed “susceptible exposed infectious recovered” (SEIR) compartmental model was employed to describe the dynamics of the COVID-19 epidemic based on epidemiological characteristics of individuals, clinical progression of COVID-19, and quarantine intervention measures of the authority. | 2020-04-03 |
| 32243607 | Electronical medical records, including demographics, clinical characteristics, laboratory and radiological findings, of enrolled patients were extracted and analyzed. […] Viral shedding at multiple time points in specimens was recorded, and analyzed its correlation with clinical manifestations and the severity of illness. […] A total of 42 laboratory-confirmed patients were enrolled, 8 (19.05%) of whom had gastrointestinal symptoms. […] 28 (66.67%) patients tested positive for SARS-CoV-2 RNA in stool specimens, which was not associated with the presence of gastrointestinal symptoms and the severity of illness. […] The demographics, clinical characteristics, laboratory and radiologic findings did no differ between patients tested positive and negative for SARS-CoV-2 RNA in feces. | 2020-04-03 |
| 32243668 | This include changes to resource allocation, clinical care, and the consent process during a pandemic. | 2020-04-05 |
| 32243672 | The clinical manifestation of COVID-19 can vary from an asymptomatic course to ARDS requiring invasive mechanical ventilation and extracorporeal membrane oxygenation. | 2020-04-03 |
| 32243673 | Clinical data on COVID-19 infection in transplant population is very limited. […] Herein we presented the clinical course and outcome of a 50-year-old male post liver transplantation who contracted COVID-19, with subsequent infection of his wife. | 2020-04-03 |
| 32243690 | The initial clinical symptoms of COVID-19 in these three patients were the same, but their progression was different. […] Based on the severity of clinical symptoms, chest computer tomography findings and SARS-Cov-2 RNA test results, we admitted the husband to the respiratory intensive care unit (RICU) and used a treatment consisting of immunosuppressant reduction/cessation and low dose methylprednisolone-based therapy, and his wife to the respiratory isolation ward. | 2020-04-03 |
| 32244166 | Clinical manifestation of COVID-19 can be characterized by mild upper respiratory tract infection, lower respiratory tract infection involving non-life threatening pneumonia, and life-threatening pneumonia with acute respiratory distress syndrome. | 2020-04-16 |
| 32244415 | The coronavirus disease 2019 (COVID-19) epidemic affects people’s health and health-related quality of life (HRQoL), especially in those who have suspected COVID-19 symptoms (S-COVID-19-S). […] The interviews were conducted using printed questionnaires including participants’ characteristics, clinical parameters, health behaviors, HL, depression, and HRQoL. | 2020-04-06 |
| 32245083 | Based on clinical criteria and available serological and molecular information, the new disease was called coronavirus disease of 2019 (COVID-19), and the novel coronavirus was called SARS Coronavirus-2 (SARS-CoV-2), emphasizing its close relationship to the 2002 SARS virus (SARS-CoV). | 2020-04-06 |
| 32245395 | In the guideline, except for “confirmed cases”, “suspected cases”, “close contact” and “suspicious exposure” were defined by clinical perspective based on epidemiological risk, clinical symptoms and auxiliary examination. | 2020-04-10 |
| 32245396 | However, the coronavirus disease 2019 (COVID-19) is a new disease, our awareness and knowledge are gradually increasing based on the ongoing research findings and clinical practice experience; hence, the strategies of diagnosis and treatment are also continually updated. | 2020-04-10 |
| 32245835 | The COVID-19 outbreak has had a major impact on clinical microbiology laboratories in the past several months. | 2020-04-04 |
| 32246317 | Coagulation results and clinical features of consecutive patients with severe pneumonia induced by SARS-CoV2 (COVID group) and non-SARS-CoV2 (non-COVID group) in Tongji hospital were retrospectively analyzed and compared. | 2020-04-04 |
| 32246782 | The published clinical features of COVID-19 do not suggest that involvement of the CNS is common. | 2020-04-04 |
| 32246783 | In a recent review, we have suggested a neuroinvasive potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its possible role in the causation of acute respiratory failure of coronavirus disease 2019 (COVID-19) patients (J Med Viol doi: 10.1002/jmv.25728), based upon the clinical and experimental data available on the past SARS-CoV-1 and the recent SARS-CoV-2 pandemic. | 2020-04-10 |
| 32246819 | All patients underwent thoracic high-resolution computed tomography (HRCT) within 2 days after the onset of symptoms, and their images were viewed by 2 radiologists who were blind to their clinical records. […] Thus, suspected cases need to be closely monitored, and epidemiological history and clinical laboratory examination should also be considered during diagnosis. | 2020-04-09 |
| 32246834 | In addition to the recommended antiviral drugs such as interferon-ɑ, lopinavir/ritonavir, ribavirin, and chloroquine phosphate, some clinical trials focusing on virus RNA dependent RNA polymerase (RdRp) inhibitors have been registered and initiated. […] Favipiravir, a purine nucleic acid analog and potent RdRp inhibitor approved for use in influenza, is also considered in several clinical trials. […] We hope this will be helpful for the design of clinical trials for favipiravir in COVID-2019, as data regarding in vitro virus inhibition and efficacy in preclinical animal studies are still not available. | 2020-04-04 |
| 32246890 | Compared to N95 respirators; the use of medical masks did not increase laboratory confirmed viral (including coronaviruses) respiratory infection (OR 1.06; 95% CI 0.90-1.25; I2 =0%; low certainty in the evidence) or clinical respiratory illness (OR 1.49; 95%CI 0.98-2.28; I2 =78%; very low certainty in the evidence). | 2020-04-04 |
| 32247050 | Based on recently published literatures, official documents and selected up-to-date preprint studies, we reviewed the virology and origin, epidemiology, clinical manifestations, pathology and treatment of 2019-nCoV infection, in comparison with severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV) infection. […] Clinical presentation and pathology of COVID-19 greatly resembled SARS and MERS, with less upper respiratory and gastrointestinal symptoms, and more exudative lesions in post-mortems. | 2020-04-07 |
| 32247211 | Considering minimal risk upon use, a long experience of use in other diseases, cost-effectiveness and easy availability across India, we propose that both these drugs are worthy of fast track clinical trial for treatment, and may be carefully considered for clinical use as experimental drugs. | 2020-04-10 |
| 32247212 | Respiratory illness is the dominant clinical manifestation of COVID-19; CV involvement occurs much less commonly. […] Given the enormous burden posed by this illness and the significant adverse prognostic impact of cardiac involvement, further research is required to understand the incidence, mechanisms, clinical presentation and outcomes of various CV manifestations in COVID-19 patients. | 2020-04-16 |
| 32247213 | We discuss evidence regarding role of chloroquine and hydroxychloroquine in treatment and prophylaxis, use of inhibitors of the renin angiotensin system, safety of ibuprofen, unusual clinical features like gastrointestinal symptoms and interpretation of tests for cardiac enzymes and biomarkers. | 2020-04-16 |
| 32247326 | Our estimates of the incubation period and serial interval were similar, suggesting an early peak of infectiousness, with possible transmission before the onset of symptoms. | 2020-04-05 |
| 32247826 | We collected epidemiological and clinical characteristics, laboratory outcomes from electronic medical records, and also affirmed them with the patients and their families. […] Case 2 presented no clinical or radiographic abnormalities. | 2020-04-09 |
| 32247836 | This algorithm is based on urgency of operation, anticipated viral burden at the surgical site, opportunity for a procedure to aerosolize virus, and likelihood a patient could be infected based on symptoms and testing. | 2020-04-05 |
| 32247926 | Here, we report the main clinical findings, and epidemiological features of the first series of cases, and a cluster, confirmed in Bolivia. […] Nine patients presented fever, and cough, five sore throat, and myalgia, among other symptoms. | 2020-04-11 |
| 32247927 | China has also taken immediate action to put remdesivir into clinical trials with the purpose of applying it into clinical therapeutics for Corona Virus Disease 2019 (COVID-19). | 2020-04-14 |
| 32248387 | Finally, a few clinical examples of how DAMPs and SAMPs might be used as therapeutic targets or therapeutics in the future are discussed, including inhibition of DAMPs in hyperinflammatory processes (e.g., systemic inflammatory response syndrome, as currently observed in Covid-19), administration of SAMPs in chronic inflammatory diseases, inhibition of SAMPs in hyperresolving processes (e.g., compensatory anti-inflammatory response syndrome), and administration/induction of DAMPs in vaccination procedures and anti-cancer therapy. | 2020-04-05 |
| 32248675 | Lower rather than upper respiratory tract viral burden correlates with clinical severity of illness. | 2020-04-06 |
| 32248966 | Coronavirus disease 2019 (COVID-19), caused by a novel betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first described in a cluster of patients presenting with pneumonia symptoms in Wuhan, China, in December of 2019. […] COVID-19 results in mild symptoms in the majority of infected patients, but can cause severe lung injury, cardiac injury, and death. | 2020-04-09 |
| 32249089 | To present the epidemiological, clinical, and therapeutic characteristics of KTx recipients infected with COVID-19, we report on a case series of five patients who were confirmed as having COVID-19 through nucleic acid testing (NAT) from January 1, 2020 to February 28, 2020. […] The most common symptoms on admission to hospital were fever (five patients, 100%), cough (five patients, 100%), myalgia or fatigue (three patients, 60%), and sputum production (three patients, 60%); serum creatinine or urea nitrogen levels were slightly higher than those before symptom onset. | 2020-04-06 |
| 32249102 | Pharmacists shall use various approaches to provide PC services in drug dispensing, consulting and referrals, chronic disease management, safe use of infusions, patient education, home care guidance and psychological support to promote the COVID-19 pandemic control and ensure safe medication use of community patients during the pandemic. | 2020-04-09 |
| 32249203 | We comprehensively tested the pre-clinical immunogenicity of MERS-CoV vaccines in mice when delivered subcutaneously by traditional needle injection, or intracutaneously by dissolving microneedle arrays (MNAs) by evaluating virus specific IgG antibodies in the serum of vaccinated mice by ELISA and using virus neutralization assays. […] Driven by the urgent need for COVID-19 vaccines, we utilized this strategy to rapidly develop MNA SARS-CoV-2 subunit vaccines and tested their pre-clinical immunogenicity in vivo by exploiting our substantial experience with MNA MERS-CoV vaccines. […] Here we describe the development of MNA delivered MERS-CoV vaccines and their pre-clinical immunogenicity. […] Building on our ongoing efforts to develop MERS-CoV vaccines, promising immunogenicity of MNA-delivered MERS-CoV vaccines, and our experience with MNA fabrication and delivery, including clinical trials, we rapidly designed and produced clinically-translatable MNA SARS-CoV-2 subunit vaccines within 4 weeks of the identification of the SARS-CoV-2 S1 sequence. […] Collectively, our results support the clinical development of MNA delivered recombinant protein subunit vaccines against SARS, MERS, COVID-19, and other emerging infectious diseases. | 2020-04-16 |
| 32249257 | With no vaccines or drugs approved for prevention and treatment until now, all efforts at drug design and/or clinical trials of already approved drugs are worthy and creditable. | 2020-04-06 |
| 32249918 | We conducted a case-control study to compare clinical characteristics, maternal and neonatal outcomes of pregnant women with and without COVID-19 pneumonia. […] Few patients presented respiratory symptoms (fever and cough) on admission, but most had typical chest CT images of COVID-19 pneumonia. […] Mild respiratory symptoms of pregnant women with COVID-19 pneumonia highlight the need of effective screening on admission. | 2020-04-06 |
| 32249943 | Children and adults show a different clinical course. […] The purpose of the current study is to comparatively analyze the clinical characteristics of 2019-nCoV infection in children and adults and to explore the possible causes for the discrepancies present. […] The medical records of 25 adults and 7 children confirmed cases of 2019-nCoV ARD were reviewed retrospectively. […] In summary, knowledge of these differences between children and adults will not only be helpful for the clinical diagnosis of 2019 novel coronavirus disease (COVID-19), but also for a future discussion on age-specific coronavirus infection. | 2020-04-06 |
| 32250049 | Few children have been reported to have been affected by novel coronavirus disease 2019 (COVID-19); it is unclear whether children are less likely to be infected or rather display fewer symptoms. […] We argue that in epidemic settings children presenting with any mild symptom potentially attributable to COVID-19 should be considered contagious until proven otherwise, and that management must be guided by clinical conditions. | 2020-04-06 |
| 32250170 | The technology to produce plant-made biopharmaceuticals is already established; two examples of these are: a therapeutic enzyme that has entered the market and the influenza vaccines that are currently under clinical trials with encouraging results. […] In particular, plant-made antibodies might be timely produced and approved for human use in the short term, while the development of vaccines will take longer time (clinical evaluations could be concluded by the end of 2021); nonetheless, the candidates obtained will be valuable tools for future outbreaks. | 2020-04-16 |
| 32250244 | Based on the current clinical evidence treatment with ACE-inhibitors I (ACEis) or angiotensin receptor blockers (ARBs) continues to provide cardiovascular and renal protection in patients diagnosed with COVID-19. | 2020-04-15 |
| 32250281 | As the medical landscape changes daily with the coronavirus disease (COVID-19) pandemic, clinical researchers are caught off-guard and are forced to make decisions on research visits in their ongoing clinical trials. | 2020-04-14 |
| 32250385 | Information about the clinical characteristics of infected patients who require intensive care is limited. […] Demographic and clinical data were collected, including data on clinical management, respiratory failure, and patient mortality. | 2020-04-09 |
| 32250505 | The COVID-19 epidemiological and clinical characteristics are still being collated but children’s symptoms seem to be milder than those that adults experience. | 2020-04-16 |
| 32250958 | On a 10-point Likert scale, the ability of the app to reassure staff in clinical practice was rated as 7.6 (SD 2.1), time-saving ability was rated as 8.5 (SD 2.1), and the need to look for information from other sources was rated as 5.9 (SD 3.3). […] More research should be done on the clinical impact and outcomes of the integration of mHealth solutions as a communication channel of validated information within health institutions. | 2020-04-16 |
| 32250959 | The questionnaire was comprised of a series of questions about dentists’ demographic characteristics; their awareness of the incubation period, the symptoms of the disease, mode of transmission of COVID-19 and infection control measures for preventing COVID-19; and their attitude toward treating patients with COVID-19. […] The majority of dentists were aware of COVID-19 symptoms and ways of identifying patients at risk of having COVID-19, were able to correctly report known modes of transmission, and were aware of measures for preventing COVID-19 transmission in dental clinics. […] Jordanian dentists were aware of COVID-19 symptoms, mode of transmission, and infection controls and measures in dental clinics. […] National and international guidelines should be sent by the regional and national dental associations to all registered dentists during a crisis, including the COVID-19 pandemic, to make sure that dentists are well informed and aware of best practices and recommended disease management approaches. | 2020-04-14 |
| 32250962 | Symptoms were recorded and compared with reported patients with COVID-19. […] A total of 94.20% (n=4628) of counselees had epidemic-related symptoms with a distribution similar to those of COVID-19. […] Adult counselees (odds ratio [OR]=1.816, P<.001) with epidemiological exposure (OR 7.568, P<.001), shortness of breath (OR 1.440, P=.001), diarrhea (OR 1.272, P=.04), and unrelated symptoms (OR 1.509, P<.001) were more likely to have hypochondriacal suspicion. | 2020-04-16 |
| 32251002 | Respiratory rehabilitation is an important intervention as well as cure for clinical patients. […] With increased understanding of COVID-19 and the accumulation of clinical experience, we proposed recommendations for respiratory rehabilitation in adults with COVID-19 based on the opinions of frontline clinical experts involved in the management of this epidemic and a review of the relevant literature and evidence. […] Our recommendations are as follows: 1. for inpatients with COVID-19, respiratory rehabilitation would relieve the symptoms of dyspnea, anxiety, and depression and eventually improve physical functions and the quality of life; 2. for severe/critical inpatients, early respiratory rehabilitation is not suggested; 3. for patients in isolation, respiratory rehabilitation guidance should be conducted through educational videos, instruction manuals, or remote consultation; 4. assessment and monitoring should be performed throughout the respiratory rehabilitation process; 5. proper grade protection should be used following the present guidelines. […] These recommendations can guide clinical practice and form the basis for respiratory rehabilitation in COVID-19 patients. | 2020-04-13 |
| 32251003 | The pathological results of the explanted lungs were concordant with the critical clinical manifestation, and provided insight towards better understanding of the disease. | 2020-04-06 |
| 32251618 | PubMed, Google Scholar and Science Direct databases were searched Results: A total 22 articles were found eligible. 8 discuss about treatment outcomes from their applied drugs during treatment of COVID-19 patients, 4 report laboratory tests, one report animal trial and other 9 articles discuss recommendations and suggestions based on the treatment process and clinical outcomes of other diseases such as malaria, ebola, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). […] All examined treatments, although potentiality effective against COVID-19, need either appropriate drug development or clinical trial to be suitable for clinical use. | 2020-04-13 |
| 32251668 | Infection with SARS-CoV-2 causes COVID-19, which has been characterized by fever, respiratory, and gastrointestinal symptoms as well as shedding of virus RNA into feces. […] We performed a systematic review and meta-analysis of published gastrointestinal symptoms and detection of virus in stool, and also summarized data from a cohort of patients with COVID-19 in Hong Kong. […] We analyzed pooled data on the prevalence of overall and individual gastrointestinal symptoms (anorexia, nausea, vomiting, diarrhea, and abdominal pain or discomfort) using a random effects model. […] Among the 59 patients with COVID-19 in Hong Kong, 15 patients (25.4%) had gastrointestinal symptoms and 9 patients (15.3%) had stool that tested positive for virus RNA. […] In a meta-analysis of 60 studies, comprising 4243 patients, the pooled prevalence of all gastrointestinal symptoms was 17.6% (95% CI, 12.3%-24.5%); 11.8% of patients with non-severe COVID-19 had gastrointestinal symptoms (95% CI, 4.1%-29.1%) and 17.1% of patients with severe COVID-19 had gastrointestinal symptoms (95% CI, 6.9%-36.7%). […] In an analysis of data from the Hong Kong cohort of patients with COVID-19 and a meta-analysis of findings from publications, we found that 17.6% of patients with COVID-19 had gastrointestinal symptoms. | 2020-04-06 |
| 32251729 | Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. […] Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. […] Patients with laboratory confirmed SARS-CoV-2 infection (under RT PCR) and clinical picture that involves temperature >37.5 oC and at least two out of the: i. sustained coughing, ii. sustained throat pain, iii. […] GRECCO-19 trial aims to identify whether colchicine may positively intervene in the clinical course of COVID-19. | 2020-04-06 |
| 32251731 | This domain (111-158), which is fully conserved among clinical isolates worldwide, may improve attachment of the virus to lipid rafts and facilitate contact with the ACE-2 receptor. […] The in-silico approaches used in this study might also be used to assess the efficiency of a broad range of repositioned and/or innovative drug candidates before clinical evaluation. | 2020-04-14 |
| 32251767 | We evaluated the in vitro antiviral effect of compounds that were previously reported to inhibit coronavirus replication and compounds that are currently under evaluation in clinical trials for SARS-CoV-2 patients. […] Ribavirin or favipiravir that are currently evaluated under clinical trials showed no inhibition at 100 μM. […] Combinational therapy may help to reduce the effective concentration of compounds below the therapeutic plasma concentrations and provide better clinical benefits. | 2020-04-16 |
| 32251768 | Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. | 2020-04-09 |
| 32251790 | To prevent further outbreak of COVID-19, this article discusses the current understanding of COVID-19 and compares with the outbreak of SARS-CoV-2 in 2003 of Hong Kong from the causes, transmission, symptoms, diagnosis, treatments and preventions to study for an applicable measurement to control COVID-19. | 2020-04-06 |
| 32251791 | This case warns the physicians of patients who have CNS symptoms. | 2020-04-06 |
| 32251794 | In this study, we described and discussed the clinical outcomes of ECMO for ARDS patients, ECMO use for severe COVID-19 in China, the indications of ECMO use, and some important issues associated with ECMO. | 2020-04-06 |
| 32251805 | This study aims to summarize the clinical characteristics of death cases with COVID-19 and to identify critically ill patients of COVID-19 early and reduce their mortality. […] The clinical records, laboratory findings and radiological assessments included chest X-ray or computed tomography were extracted from electronic medical records of 25 died patients with COVID-19 in Renmin Hospital of Wuhan University from Jan 14 to Feb 13, 2020. […] The clinical characteristics of 25 death cases with COVID-19 we summarized, which would be helpful to identify critically ill patients of COVID-19 early and reduce their mortality. | 2020-04-09 |
| 32251842 | Describe the clinical characteristics of patients in Fangcang Hospital. […] Non-critically ill patients with positive SARS-CoV-2 RT-PCR tests admitted to Dongxihu ‘Fangcang’ Hospital between February 7th and 12th were included, which was promptly constructed because of the rapid, exponential increase in COVID-19 patients in Wuhan, China; clinical course through February 22nd was recorded. 1012 non-critically ill patients with positive SARS-CoV-2 RT-PCR tests were included in the study. 30 (of 1012, 3.0%) patients were asymptomatic on admission. […] During hospitalization, 16 of 30 (53.3%) asymptomatic patients suffered from different symptoms. […] Fever (761 of 1012, 75.2%) and cough (531 of 1012, 52.4%) were the most common symptoms. […] Non-critically ill patients had different clinical characteristics than critically ill patients. | 2020-04-06 |
| 32252023 | The aim of this study was to explore the trends in confirmed COVID-19 cases in North Carolina, and to understand patterns in virtual visits related to symptoms of COVID-19. […] Of the total visits, 257 (35.1%) were related to COVID-19-like symptoms. | 2020-04-16 |
| 32252141 | The purpose of this review is to summarize known-to-date information about SARS-CoV-2, transmission of SARS-CoV-2, and clinical features. | 2020-04-17 |
| 32252338 | Several observational studies and clinical trials reported that vitamin D supplementation reduced the risk of influenza, whereas others did not. | 2020-04-10 |
| 32252591 | Infection with the novel coronavirus, SARS-CoV-2, produces a clinical syndrome known as COVID-19. | 2020-04-15 |
| 32252784 | Their common clinical manifestations, as well as characteristics and evolvement features of chest CT images, were analyzed. […] The clinical manifestations of COVID-19 included cough, fever. | 2020-04-10 |
| 32252845 | This extreme measure never seen before during peace time was the result of adapting not only the French Pandemic Influenza Plan (PIP) being applied to the national context but also real-time clinical, epidemiological and scientific information about the evolution of COVID-19 infection in the country. | 2020-04-07 |
| 32253068 | SARS-CoV2 spread from China where the first infections were described in December 2019 and is responsible for the respiratory symptoms that can lead to acute respiratory distress syndrome. | 2020-04-15 |
| 32253172 | This involvement may have important implications to the disease management, transmission, and prognosis, especially in patients with pre-existing hepatic or digestive co-morbidities. | 2020-04-07 |
| 32253318 | The second endpoints were the improvement of clinical symptoms and laboratory parameters within 3 d after CP transfusion. […] The clinical symptoms were significantly improved along with increase of oxyhemoglobin saturation within 3 d. […] This study showed CP therapy was well tolerated and could potentially improve the clinical outcomes through neutralizing viremia in severe COVID-19 cases. […] The optimal dose and time point, as well as the clinical benefit of CP therapy, needs further investigation in larger well-controlled trials. | 2020-04-07 |
| 32253371 | To provide insights on this issue, a 25-items online Survey was sent to all Italian residents one month after the first case of COVID-19 in Italy, to evaluate their routine involvement in “clinical” (on-call duty, outpatient visits, diagnostic procedures) and “surgical” (endoscopic, open and minimally invasive surgery) training activities before and during the COVID-19 period. […] Before the COVID-19 pandemic, the proportion of residents routinely involved in “clinical” and “surgical” activities ranged from 79.8% to 87.2% and from 49.3% to 73.5%, respectively. […] In the COVID-19 period, the proportion of residents experiencing a severe reduction (>40%) or complete suppression (>80%) of training exposure ranged between 41.1% and 81.2% for “clinical” activities while between 44.2% and 62.1% for “surgical” activities. | 2020-04-07 |
| 32253449 | Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. | 2020-04-09 |
| 32253535 | The following epidemiological and clinical outcomes have been studied: age, sex, ethnicity, comorbidities, and general and otolaryngological symptoms. […] The most prevalent general symptoms consisted of cough, myalgia, and loss of appetite. […] Face pain and nasal obstruction were the most disease-related otolaryngological symptoms. […] Olfactory dysfunction (OD) appeared before the other symptoms in 11.8% of cases. […] Olfactory and gustatory disorders are prevalent symptoms in European COVID-19 patients, who may not have nasal symptoms. […] The sudden anosmia or ageusia need to be recognized by the international scientific community as important symptoms of the COVID-19 infection. | 2020-04-07 |
| 32253759 | The demographic, treatment, laboratory parameters of C-reactive protein (CRP) and IL-6 before and after TCZ therapy and clinical outcome in the 15 COVID-19 patients were retrospectively assessed. […] Although TCZ treatment ameliorated the increased CRP in all patients rapidly, for the four critically ill patients who received an only single dose of TCZ, three of them (No. 1, 2, and 3) still dead and the CRP level in the rest one patient (No. 7) failed to return to normal range with a clinical outcome of disease aggravation. | 2020-04-15 |
| 32253771 | This video conference method can be applied to clinical as well as anatomy lessons. | 2020-04-07 |
| 32253890 | A series of specific suggestions are put forward including the establishment of a full-chain closed-loop research system to support the cultivation of top-notch innovative public health talents, strengthening the assessment of core public health capabilities for clinical medical professional admission, formulating a “medical and preventive integration” training program for primary health personnel, and implementing “combination of peace and war” public health personnel reserve system, with the purpose of providing reference for the reform and development of preventive medical education in China. | 2020-04-07 |
| 32254064 | Convalescent plasma has also been used in the COVID-19 pandemic; limited data from China suggest clinical benefit, including radiological resolution, reduction in viral loads and improved survival. […] Data from rigorously controlled clinical trials of convalescent plasma are also few, underscoring the need to evaluate its use objectively for a range of indications (e.g., prevention vs treatment) and patient populations (e.g., age, comorbid disease). […] We provide an overview of convalescent plasma, from evidence of benefit, regulatory considerations, logistical work flow and proposed clinical trials, as scale up is brought underway to mobilize this critical resource. . | 2020-04-07 |
| 32255382 | Demographic, clinical, laboratory, and treatment data were collected and analyzed, and final date of follow-up was February 24, 2020. […] Our findings should aid in the recognition and clinical management of such infections, especially ICU resource allocation. | 2020-04-07 |
| 32255413 | Fourteen key questions, corresponding to 11 decision points within the three scenarios and three additional clinical situations, were rated by the panel based upon the anticipated value of the information that thoracic imaging would be expected to provide. | 2020-04-08 |
| 32255437 | The chest CT images and clinical data were reviewed. […] The most prevalent presenting symptoms were fever (64%) and cough (59%), and a mildly elevated mean (SD) C-reactive protein (CRP) level of 11.22(11.06) and erythrocyte sedimentation rate of 18.8 (15.17) were detected. […] Children with COVID-19 had relatively milder symptoms and less severe lung inflammation than adults. | 2020-04-07 |
| 32255489 | However, all ongoing clinical trials with HCQ use different dosing regimens, resulting on various concentrations PK studies are therefore needed to define the optimal dosing regimen. | 2020-04-07 |
| 32255510 | In patients who develop symptoms or signs of an upper respiratory tract infection, but COVID-19 is not yet confirmed, consider dose reduction or temporarily cessation for 1-2 weeks. | 2020-04-07 |
| 32255567 | The COVID-19 Emergency Department (COVED) Quality Improvement Project has commenced and will provide flexible and responsive clinical tools to determine the predictors of key ED-relevant clinical outcomes. […] Regression methodology will be used to generate clinical prediction tools. | 2020-04-07 |
| 32255648 | Sharing of data for COVID-19 applications will help connect scientists across the global biomolecular simulation community, and also improve connection and communication between simulation and experimental and clinical data and investigators. | 2020-04-07 |
| 32256547 | More than 80 clinical trials have been launched to test coronavirus treatment, including some drug repurposing or repositioning for COVID-19. […] The eligibility criteria for the retrieved studies were: contain a clinicaltrials.gov base identifier number; describe the number of participants and the period for the study; describe the participants’ clinical conditions; and utilize interventions with medicines already studied or approved for any other disease in patients infected with the novel coronavirus SARS-CoV-2 (2019-nCoV). […] We identified 24 clinical trials, involving more than 20 medicines, such as human immunoglobulin, interferons, chloroquine, hydroxychloroquine, arbidol, remdesivir, favipiravir, lopinavir, ritonavir, oseltamivir, methylprednisolone, bevacizumab, and traditional Chinese medicines (TCM). […] Although drug repurposing has some limitations, repositioning clinical trials may represent an attractive strategy because they facilitate the discovery of new classes of medicines; they have lower costs and take less time to reach the market; and there are existing pharmaceutical supply chains for formulation and distribution. | 2020-04-09 |
| 32256705 | The mycophenolate mofetil picture is less clear, with conflicting data from pre-clinical studies. | 2020-04-09 |
| 32256706 | There have been a number of reports stating that non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids may exacerbate symptoms in COVID-19 patients. | 2020-04-09 |
| 32257173 | Outbreaks of novel agents represent opportunities for clinical research to inform real-time public health action. […] Here, we review information available on COVID-19 and provide an evidenced-based framework for priority clinical research in the current outbreak. […] Three bibliographic databases were searched to identify clinical studies published on SARS-CoV and MERS-CoV in the outbreak setting. […] Studies were grouped thematically according to clinical research questions addressed. […] From the research objectives for SARS-CoV and MERS-CoV, ten themes in the literature were identified: Clinical characterisation, prognosis, diagnosis, clinical management, viral pathogenesis, epidemiological characterisation, infection prevention and control/transmission, susceptibility, psychosocial, and aetiology. […] For COVID19, some information on clinical presentation, diagnostic testing, and aetiology is available but many clinical research gaps have yet to be filled. […] Based on a systematic review of other severe coronaviruses, we summarise the state of clinical research for COVID-19, highlight the research gaps, and provide recommendations for the implementation of standardised protocols. […] Data based on internationally standardised protocols will inform clinical practice real-time. | 2020-04-15 |
| 32257431 | However, few broad-spectrum antiviral drugs have been evaluated against COVID-19 in clinical trials, resulted in clinical recovery. | 2020-04-09 |
| 32257537 | The clinical outcomes, as well as changes of inflammatory and immune function levels and adverse effects of 7 enrolled patients were assessed for 14 days after MSC injection. […] The pulmonary function and symptoms of these seven patients were significantly improved in 2 days after MSC transplantation. | 2020-04-09 |
| 32257554 | A new study published by the journal Aging & Disease reported that intravenous administration of clinical-grade human mesenchymal stem cells (MSCs) into patients with coronavirus disease 2019 (COVID-19) resulted in improved functional outcomes (Leng et al., Aging Dis, 11:216-228, 2020). | 2020-04-09 |
| 32257728 | This article looks to review specific epidemiological factors, symptomatology, laboratory and imaging workup, and other relevant metrics derived from the limited published literature that are specific to the pediatric population, to provide a review for the pediatric practitioner and guide, in part, the creation of a clinical algorithm for the management of COVID-19 in the pediatric population that can be utilized by pediatric institutions. | 2020-04-09 |
| 32258351 | Remdesivir (GS-5734™) is a broad-spectrum antiviral drug that is now being tested as a potential treatment for COVID-19 in international, multi-site clinical trials. […] As the pandemic progresses, information from human compassionate use cases will continue to accumulate before the clinical trials are concluded. | 2020-04-07 |
| 32259130 | There are significant misconceptions and many obstacles in the way of illuminating the epidemiological and clinical aspects of COVID-19 as a new emerging epidemic. […] However, misinterpreting or ignoring strong evidence in clinical practice and public health probably results in less effective and somehow more harmful decisions for individuals as well as subgroups in general populations of countries in the initial stages of this epidemic. […] Accordingly, our narrative review appraised epidemiological and clinical aspects of the disease including genetic diversity of coronavirus genus, mode of transmission, incubation period, infectivity, pathogenicity, virulence, immunogenicity, diagnosis, surveillance, clinical case management and also successful measures for preventing its spread in some communities. | 2020-04-09 |
| 32259197 | The coronavirus disease 2019 (COVID-19) pandemic challenges hospital leaders to make time-sensitive, critical decisions about clinical operations and resource allocations. […] To estimate the timing of surges in clinical demand and the best- and worst-case scenarios of local COVID-19-induced strain on hospital capacity, and thus inform clinical operations and staffing demands and identify when hospital capacity would be saturated. | 2020-04-15 |
| 32259247 | Although this document provides a framework for pain management services, systems-wide and individual decisions must take into account clinical considerations, regional health conditions, government and hospital directives, resource availability, the welfare of health care providers. | 2020-04-07 |
| 32259279 | The objective of this study was to summarize the clinical manifestations and maternal and perinatal outcomes of COVID-19 during pregnancy. […] Multiple terms and combinations were used including COVID-19, pregnancy, maternal mortality, maternal morbidity, complications, clinical manifestations, neonatal morbidity, intrauterine fetal death, neonatal mortality and SARS-CoV-2. […] Data on clinical manifestations, maternal and perinatal outcomes including vertical transmission were extracted and analyzed. | 2020-04-07 |
| 32259313 | Therapies include novel agents available in clinical trials or through compassionate use, and other drugs, repurposed antiviral and immune modulating therapies. […] The purpose of this review is to summarize practical considerations for pharmacotherapy in patients with COVID-19, with the intent of serving as a resource for health care providers at the forefront of clinical care during this pandemic. | 2020-04-07 |
| 32259322 | From a large medical center in Wuhan, the epicenter of the 2019 novel coronavirus disease (COVID-19), we report clinical features and prognosis for three women diagnosed with COVID-19 after gynecologic oncology surgery and hospitalized in January 2020. […] By February 20, 2020, only two of the three patients had met the clinical discharge criteria. | 2020-04-13 |
| 32259403 | Epidemiological and clinical data of these children were collected and analyzed. […] The initial symptoms of the nine children were mild, including fever (3/9), diarrhea (2/9), cough (1/9), and sore throat (1/9), two had no symptoms. […] The clinical symptoms of the new coronavirus infection in children were not typical and showed a less aggressive clinical course than teenage and adult patients. | 2020-04-07 |
| 32259419 | Clinical decision scores may support the clinician’s decision-making, especially if properly adapted for this unique pandemic and for the patient being treated. […] This review discusses the use of clinical prediction scores for pneumonia severity at 3 main decision points to examine which scores may provide value in this unique situation. […] Initial data from a cohort of over 44,000 COVID-19 patients in China, including risk factors for mortality, were compared with data from cohorts used to study the clinical scores, in order to estimate the potential appropriateness of each score and determine how to best adjust results at the bedside. | 2020-04-09 |
| 32259546 | Respiratory specimens were collected from contacts who developed fever, and/or respiratory symptoms during the surveillance period and were tested for SARS-CoV-2. | 2020-04-09 |
| 32259853 | Diagnosis relies on clinical presentation, exposure history, PCR using specimens from the respiratory tract together with computed tomography (CT) imaging. | 2020-04-07 |
| 32259899 | It is known that many test-positive individuals may not develop symptoms or have a mild self-limited viral syndrome consisting of fever, malaise, dry cough, and constitutional symptoms. | 2020-04-10 |
| 32260436 | In the clinical routine, prolonged postanesthetic respiratory instability worsens the patient outcome. | 2020-04-10 |
| 32260471 | However, the performance of IVD assays needs to be critically evaluated before they are employed for the clinical diagnosis of COVID-19. | 2020-04-08 |
| 32264666 | The clinical features were on a large scale that varies from being an asymptomatic carrier to acute respiratory distress syndrome and multiorgan dysfunction. […] Fever, dry cough and fatigue are the most common symptoms. | 2020-04-08 |
| 32264791 | Recombinant human ACE2 has completed clinical trials and efficiently lowered or increased plasma angiotensin II and angiotensin 1-7 levels, respectively. | 2020-04-08 |
| 32264898 | We aim to describe recommended clinical pathways for COVID-19-positive patients requiring acute non-deferrable surgical care. | 2020-04-10 |
| 32265065 | Symptoms of COVID-19 are similar to other viral upper respiratory illnesses. […] Three major trajectories include mild disease with upper respiratory symptoms, non-severe pneumonia, and severe pneumonia complicated by acute respiratory distress syndrome (ARDS). […] Disposition depends on patient symptoms, hemodynamic status, and patient ability to self-quarantine. | 2020-04-10 |
| 32265182 | A number of in vivo clinical trials are underway. […] High quality, adequately powered randomised clinical trials in primary and secondary care settings are urgently required to guide policymakers and clinicians. | 2020-04-08 |
| 32265202 | Precautionary measures are recommended when examining infected patients throughout the clinical course of the infection. | 2020-04-08 |
| 32265220 | The most reported predictors of presence of covid-19 in patients with suspected disease included age, body temperature, and signs and symptoms. […] Methodological guidance should be followed because unreliable predictions could cause more harm than benefit in guiding clinical decisions. | 2020-04-10 |
| 32265310 | Limited pre-clinical data suggest that systemic MSC administration can significantly reduce respiratory virus (Influenza strains H5N1 and H9N2)-induced lung injury, however, there are no available data in models of coronavirus respiratory infection.There are a rapidly increasing number of clinical investigations of cell-based therapy approaches for COVID-19. […] To provide a rationale strategy to maximise potential therapeutic use, it is critically important to understand the relevant pre-clinical studies and postulated mechanisms of MSC actions in respiratory virus-induced lung injuries. […] These are presented along with consideration of current clinical investigations. | 2020-04-10 |
| 32265365 | The goal of this review is to provide evidence-based recommendations, or expert opinion when evidence is limited, for anesthesiologists caring for pregnant women during the COVID 19 pandemic, with a focus on preparedness and best clinical obstetric anesthesia practice. | 2020-04-08 |
| 32265372 | In the 3 months since its emergence, we have learned a great deal about its clinical management and its relevance to the pediatric critical care provider. […] In this article, we review the available literature and provide valuable insight into the clinical management of this disease, as well as information on preparedness activities that every PICU should perform. | 2020-04-08 |
| 32266184 | None of the infants developed serious clinical symptoms such as fever, cough, diarrhea, or abnormal radiologic or hematologic evidence, and all four infants were alive at the time of hospital discharge. […] This case report describes the clinical course of four live born infants, born to pregnant women with the COVID-19 infection. | 2020-04-10 |
| 32266987 | Virus clearance time, length of hospital stay, and duration of symptoms, by treatment type (including or not including corticosteroid therapy). […] Cox proportional hazards regression analysis indicated no association between corticosteroid treatment and virus clearance time (hazard ratio [HR], 1.26; 95% CI, 0.58-2.74), hospital length of stay (HR, 0.77; 95% CI, 0.33-1.78), or duration of symptoms (HR, 0.86; 95% CI, 0.40-1.83). | 2020-04-08 |
| 32267047 | The pediatric population has been found to be less susceptible to the disease with the majority of children having milder symptoms and only one pediatric death being reported globally so far. | 2020-04-08 |
| 32267081 | Demographic, clinical, laboratory characteristics and outcomes were recorded. […] Continuous IV anakinra infusions up to 2400 mg/day resulted in rapid serologic, then clinical response in 4/5 severely ill patients who were refractory to all other therapies including subcutaneous anakinra. […] Continuous infusion of IV anakinra may result in rapid serologic and subsequent clinical improvement in adult patients with MAS. | 2020-04-08 |
| 32267098 | As the natural history and variety of clinical presentations of this disease unfolds, the extrapulmonary symptoms of the disease have emerged, especially the symptoms related to the digestive system. […] While the respiratory mode of transmission is well-known and likely the principal mode of transmission of this disease, the possibility of the fecal-oral route of transmission has also emerged in various case series and clinical scenario. | 2020-04-08 |
| 32267110 | Also, due to the growing number of infected cases, it is clear that, in addition to the typical respiratory symptoms caused by the infection, some patients suffer from cardiovascular damage. | 2020-04-09 |
| 32267531 | The vision of this strict organization was to centralize patients in high-risk maternity centers in order to concentrate human resources and personal protective equipment (PPE), dedicate protected areas of these major hospitals, and centralize clinical multidisciplinary experience with this disease. […] The clinical presentation was interstitial pneumonia in 20 women. | 2020-04-08 |
| 32267556 | A number of novel and repurposed therapies agents with activity against SARS-CoV-2 have been identified and most institutions have developed clinical pathways to operationalize their use in appropriate COVID-19 patients.1-3 However, optimal drug therapy decisions for those with moderate to severe COVID-19 infections are extremely challenging at this time as evidence is limited. | 2020-04-08 |
| 32267613 | As a consequence, many of us who undertake clinical research have seen our work suspended. | 2020-04-08 |
| 32267771 | Clinical trial registered with ClinicalTrials.gov (NCT02735707). | 2020-04-09 |
| 32267964 | Therefore, we believe non-clinical areas are potentially high-risk for transmission between healthcare workers, and often neglected by infection prevention and control protocols. […] To alert others to this risk and how it may be reduced, we describe our non-clinical workplace infection prevention and control measures that have been modified from those originally developed during the 2003 severe acute respiratory syndrome epidemic [5]. | 2020-04-08 |
| 32267979 | Initially, the estimate for severe cases was approximated at 5% based on experience from China.1, 2 However, the World Health Organization’s (WHO) estimate from China for severe and critical cases is near 20% (Table).3 The primary clinical feature of COVID-19 is pneumonia, the severity of which directs the clinical course; it has been estimated that, of patients admitted to the ICU, up to half may require either invasive or non-invasive ventilatory support.4 This has created an unprecedented situation for emergency and critical care medicine. | 2020-04-08 |
| 32267987 | Fever, cough, and fatigue were the most common symptoms of this virus. […] Laboratory evidence of clinical patients showed that a specific T-cell response against SARS-CoV-2 is important for the recognition and killing of infected cells, particularly in the lungs of infected individuals. | 2020-04-08 |
| 32268005 | It has been reported that hydroxychloroquine (HCQ) is active against SARS-CoV-2 in vitro, and this finding was quickly supported by an open label non-randomized clinical trial that provided the first published clinical evidence HCQ may be a treatment option. | 2020-04-11 |
| 32268390 | Here we describe the rapid rollout of capabilities by UW Medicine Information Technology Services (ITS) to support our clinical response to the COVID-19 pandemic and provide recommendations for health systems to urgently consider, as they plan their own response to this and potentially other future pandemics. […] We look at how we managed expedited change control processes to quickly update electronic health records (EHR) with new COVID-19 laboratory and clinical workflows. […] The COVID-19 response requires new and expedited ways of approaching ITS support to clinical needs. […] UW Medicine ITS leadership hope that by quickly sharing our nimble response to clinical and operational requests, we can help other systems prepare to respond to this public health emergency. | 2020-04-13 |
| 32268455 | The burn microbiology laboratory of the author’s unit is a second-level biosafety laboratory, which is mainly responsible for handling clinical microbial samples from our department and other departments in the hospital. […] The specific work flow is summarized as follows to provide reference for the safety protection of peer in clinical microbiology laboratory. | 2020-04-08 |
| 32268456 | Objective: To study the clinical application effect of modified nasopharyngeal swab sampling for 2019 novel coronavirus nucleic acid detection. Methods: This study covered the period from January 14 to March 1, 2020. | 2020-04-08 |
| 32268641 | This guideline is applicable to the health protection requirements of large indoor stadiums which are reconstructed as treatment sites for COVID-19 patients with mild symptoms during the outbreak. | 2020-04-10 |
| 32268643 | Residents had higher awareness rate of cough (99.5%,n=3 997) and fever (96.0%, n=3 857) symptoms, the transmission by droplets (99.5%, n=3 995), aerosol transmission (81.1%, n=3 258), and contact transmission (92.3%, n=3 708), but lower awareness of symptoms os muscle pain or fatigue (62.7%, n=2 518). | 2020-04-10 |
| 32268984 | Based on the current understanding of COVID-19 and the clinical characteristics of cardiovascular surgical patients, the authors provide anesthesia management guidelines for cardiovascular surgery along with the prevention and control of COVID-19. | 2020-04-11 |
| 32269086 | We sought to compare the clinical characteristics and outcomes of patients being treated inside and outside Hubei province, and explore the factors underlying these differences. […] Clinical characteristics, the rate of severe events and deaths, and the time to critical illness (invasive ventilation or intensive care unit admission or death) were compared between patients in and outside of Hubei. | 2020-04-11 |
| 32269087 | Previous studies described the clinical features of Covid-19 in adults and infants under 1 year of age. […] All 4 mothers were infected by SARS-CoV-2, 3 showing symptoms before and 1 after delivery. […] The symptoms in newborn babies were milder and outcomes were less severe as compared to adults. | 2020-04-11 |
| 32269088 | All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital, Wuhan City, Hubei Province, China, between December 25, 2019 and February 7, 2020. | 2020-04-11 |
| 32269100 | In the course of optimizing SARS-CoV-2 testing performed by the University of Washington Clinical Virology Lab (UW Virology Lab), we evaluated assays using seven different primer/probe sets and one assay kit. […] These results will provide valuable information to other clinical laboratories who are actively developing SARS-CoV-2 testing protocols at a time when increased testing capacity is urgently needed worldwide. | 2020-04-09 |
| 32269177 | Currently, only a small fraction of operators has been reassigned to provide clinical services outside their scope of practice. | 2020-04-09 |
| 32269598 | There have been several reports noting anosmia and ageusia as possible symptoms of COVID-19. […] This is of particular interest in oncology since patients receiving some cancer treatments such as chemotherapy or immune therapy often experience similar symptoms as side-effects. […] The purpose of this report was to summarise the evidence on the existence of anosmia and ageusia an emerging COVID-19 symptoms in order to better inform both oncology patients and clinicians. […] Currently, there is no published evidence or case reports noting anosmia or ageusia as symptoms of COVID-19. […] Nevertheless, experts in rhinology have suggested that the onset of such symptoms could either act as a trigger for testing for the disease where possible, or could be a new criterion to self-isolate. […] Whilst more data is currently needed to strengthen our knowledge of the symptoms of COVID-19, oncology patients who are concerned about anosmia or ageusia in the context of their systemic anti-cancer therapy should contact their acute oncology support line for advice. | 2020-04-09 |
| 32269893 | There are multiple parameters of the clinical course and management of the COVID-19 that need optimization. […] This literature review aims to presents accredited and the most current studies pertaining to the basic sciences of SARS-CoV-2, clinical presentation and disease course of COVID-19, public health interventions, and current epidemiological developments. […] The review on basic sciences aims to clarify the jargon in virology, describe the virion structure of SARS-CoV-2 and present pertinent details relevant to clinical practice. […] Additionally, the clinical and epidemiological differences between COVID-19 and other infections causing outbreaks (SARS, MERS, H1N1) are elucidated. […] Emphasis is placed on evidence-based medicine to evaluate the frequency of presentation of various symptoms to create a stratification system of the most important epidemiological risk factors for COVID-19. […] Furthermore, the limitations and statistical strength of the diagnostic tools currently in clinical practice are evaluated. […] Furthermore, the biochemistry of the major candidates for novel therapies is briefly reviewed and a summary of their current status in the clinical trials is presented. | 2020-04-11 |
| 32270184 | Although SARS-CoV-2 and SARS-CoV share a number of common clinical manifestations, SARS-CoV-2 appears to be highly efficient in person-to-person transmission and frequently cause asymptomatic infections. | 2020-04-09 |
| 32270359 | However, to remain at home with stroke symptoms does not mean to “stay safe at home”. | 2020-04-11 |
| 32270371 | Along with severe acute respiratory syndrome (SARS) and Middle Eastern respiratory syndrome (MERS), COVID-19 appears to cause a severe clinical picture in humans, ranging from mild malaise to death by sepsis/acute respiratory distress syndrome. | 2020-04-09 |
| 32270413 | Clinical and epidemiological knowledge of 2019 novel coronavirus disease (COVID-19) is limited. […] This family comprised three laboratory confirmed cases with clinical symptoms. | 2020-04-09 |
| 32270477 | In the context of the COVID-19 pandemic, patients need to be evaluated within 2-4 weeks in the following cases: cytology result of “squamous cell carcinoma,” “atypical glandular cells, favor neoplastic,” “endocervical adenocarcinoma in situ,” or “adenocarcinoma”; histopathological diagnosis of suspected invasion from cervical/vaginal biopsy, or invasive disease after a cervical excision procedure, vaginal excision, or vulvar biopsy/excision; sudden onset of strongly suggestive symptoms for malignancy. | 2020-04-09 |
| 32270479 | To study chest CT images and clinical characteristics of COVID-19 pneumonia in pregnant patients to examine any correlation. […] Clinical presentations were collected retrospectively from records, including laboratory testing, chest CT imaging, and symptoms. […] Descriptive analysis and correlation of patients’ clinical and CT characteristics were performed. […] Radiological findings and clinical characteristics in pregnant women with COVID-19 were similar to those of non-pregnant women with COVID-19. | 2020-04-09 |
| 32270515 | After 7 days of treatment, he was discharged with miraculous improvement in his symptoms and hemoglobin level. | 2020-04-09 |
| 32270559 | Although coronavirus disease (COVID-19) clinical manifestations are mainly respiratory, major cardiac complications are being reported. | 2020-04-13 |
| 32270565 | Recommendations regarding clinical practice during the Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) outbreaks were also reviewed. […] Elective procedures should be postponed indefinitely, and clinical practice should be limited to patients with urgent or emergent needs. […] We summarize current best-practice recommendations for Otolaryngologists to ensure safety for themselves, their clinical staff, and their patients. | 2020-04-09 |
| 32270581 | A large number of patients do not have overt signs and symptoms (fever/respiratory), yet pose a real risk to surgeons (who should know this fact and must therefore apply respiratory protective strategies for all patients they encounter). […] Health workers who are: pregnant, over 55 to 65 years of age, with a history of chronic diseases (uncontrolled hypertension, diabetes mellitus, chronic obstructive pulmonary diseases, and all clinical scenarios where immunosuppression is feasible, including that induced to treat chronic inflammatory conditions and organ transplants) should avoid the clinical attention of a potentially infected patient. […] For those who are working with COVID-19 infected patients’ isolation is compulsory in the following settings: (a) unprotected close contact with COVID-19 pneumonia patients; (b) onset of fever, cough, shortness of breath, and other symptoms (gastrointestinal complaints, anosmia, and dysgeusia have been reported in a minority of cases). | 2020-04-15 |
| 32270592 | We reported the clinical characteristics of a case series of 10 patients with coronavirus disease 2019 (COVID-19) aged from 1 year to 18 years. […] Fever (4 [40.0%]) and cough (3 [30.0%]) were the most common symptoms. […] Our study indicated that COVID-19 children present less severe symptoms and have better outcomes. | 2020-04-09 |
| 32270660 | Objective: To summarize the clinical characteristics and liver biochemical parameters of 324 cases admitted with novel coronavirus pneumonia in Shanghai area. Methods: Clinical data and baseline liver biochemical parameters of 324 cases with novel coronavirus pneumonia admitted to the Shanghai Public Health Clinical Center from January 20, 2020 to February 24, 2020 were retrospectively analyzed. […] The differences in clinical data and baseline liver biochemical parameters of the two groups were described and compared. | 2020-04-09 |
| 32270923 | In a matter of weeks, the COVID19 crisis has totally upended clinical medicine and the practice of rheumatology. | 2020-04-09 |
| 32270938 | This finding suggests the need for strict auto-isolation of patients until the resolution of their symptoms. […] For patients that present with typical symptoms, who have a presumed Covid-19 prevalence of -40-50 %, a negative test should be interpreted with caution and a repeat test may be needed. | 2020-04-13 |
| 32271070 | However, we propose that these efforts may be limited, in part, by ongoing gaps that exist within our research and clinical care. […] In particular, we suggest that COVID-19 requires us to prioritize and mobilize as a research and clinical community around several key areas: (a) diagnostics, (b) prevention, (c) public outreach and communication, (d) working with medical staff and mainstreaming into nonmental health services, and (e) COVID-19-specific trauma research. | 2020-04-14 |
| 32271208 | A self-administered questionnaire was distributed to collect information such as social demographic variables, clinical manifestations, exposure history, awareness of the outbreak, infection control training provided by hospitals, and individual protection practices. […] The onset of symptoms was from January 13 to February 5, 2020, and peaked on January 23, 8 days prior to the peak of the public epidemic. | 2020-04-09 |
| 32271369 | All the consecutive patients with COVID-19 admitted to Fuyang second people’s hospital or the fifth medical center of Chinese PLA general hospital between January 20 and February 22, 2020, were enrolled and their clinical data were retrospectively collected. | 2020-04-09 |
| 32271454 | Employing combined therapy of modern medicine and traditional Chinese medicine has been proposed, in which Ma Xing Shi Gan Decoction (MXSGD) was recommended as a basic prescription and applied widely in the clinical treatment of COVID-19. | 2020-04-15 |
| 32271456 | In view of these conclusions, we suggested that the use of LPV/r combined with pneumonia-associated adjuvant drugs in the clinical treatment for patients with COVID-19 should be promoted. | 2020-04-15 |
| 32271459 | The purpose of this study was to investigate the clinical features of coronavirus disease 2019 (COVID-19). | 2020-04-15 |
| 32271460 | 68 (37.2%) epidemiology, 49 (26.8%) virology and 26 (14.2%) clinical features. | 2020-04-15 |
| 32271490 | In most cases, these episodes of smell loss are self-limiting and coincide with resolution of URI symptoms. | 2020-04-09 |
| 32271596 | We present four patients in this study, selected from among patients who presented with pneumonia symptoms and were suspicious for COVID-19. | 2020-04-14 |
| 32271601 | The development of highly sensitive RT-PCR has facilitated epidemiological studies that provide insight into the prevalence, seasonality, clinical manifestations and course of COVID-19 infection. | 2020-04-14 |
| 32271602 | To explain the epidemiological characteristics, clinical features, imaging manifestations and to judge diagnostic value of COVID-19 by analyzing the clinical data of COVID-19 suspected and confirmed patients in a non-outbreak, Shanghai, China. […] To clarify the early epidemiology and clinical characteristics about COVID-19. […] Epidemiology, demography, clinical, laboratory and chest CTs were collected and analyzed. […] No significant differences were found in clinical symptoms including fever, cough, dyspnea, sore throat, and fatigue (P > 0.05). […] The early clinical manifestations and imaging findings of COVID-19 are not characteristic in non-outbreak areas. | 2020-04-14 |
| 32271650 | At the time of the COVID-19 outbreak in Wuhan, they were divided into two groups: (1) the experimental group (combined mode of MOOC micro-video) and (2) the control group (traditional theory teaching combined with clinical practice teaching). | 2020-04-09 |
| 32271722 | Clinical and epidemiologic findings of all COVID-19 cases in Singapore through March 16 were reviewed to determine whether presymptomatic transmission might have occurred. […] Presymptomatic transmission was defined as the transmission of SARS-CoV-2 from an infected person (source patient) to a secondary patient before the source patient developed symptoms, as ascertained by exposure and symptom onset dates, with no evidence that the secondary patient had been exposed to anyone else with COVID-19. | 2020-04-10 |
| 32271724 | At the time the investigation began, testing guidance recommended focusing on persons with clinical findings of lower respiratory illness and travel to an affected area or an epidemiologic link to a laboratory-confirmed COVID-19 case, or on persons hospitalized for severe respiratory disease and no alternative diagnosis (1). […] For this investigation, county residents evaluated for respiratory symptoms (e.g., fever, cough, or shortness of breath) who had no known risk for COVID-19 were identified at participating urgent care centers. | 2020-04-10 |
| 32271726 | On March 10, all residents and staff members at facility 1 were tested for SARS-CoV-2, the virus that causes COVID-19, and asked to complete a questionnaire about their symptoms; all residents were tested again 7 days later. […] The three residents had no symptoms at the time of testing, although one reported an earlier cough that had resolved. | 2020-04-10 |
| 32271728 | Data from China suggest that pediatric COVID-19 cases might be less severe than cases in adults and that children might experience different symptoms than do adults (4,5); however, disease characteristics among pediatric patients in the United States have not been described. […] Data were available for a small proportion of patients on many important variables, including symptoms (9.4%), underlying conditions (13%), and hospitalization status (33%). […] Among those with available information, 73% of pediatric patients had symptoms of fever, cough, or shortness of breath compared with 93% of adults aged 18-64 years during the same period; 5.7% of all pediatric patients, or 20% of those for whom hospitalization status was known, were hospitalized, lower than the percentages hospitalized among all adults aged 18-64 years (10%) or those with known hospitalization status (33%). […] Social distancing and everyday preventive behaviors remain important for all age groups as patients with less serious illness and those without symptoms likely play an important role in disease transmission (6,7). | 2020-04-10 |
| 32271861 | Cross-sectional survey linked to 3 active clinical trials and 1 cohort study. 5 academic internal medicine practices and 2 federally qualified health centers. 630 adults aged 23 to 88 years living with 1 or more chronic conditions. […] Nearly a third could not correctly identify symptoms (28.3%) or ways to prevent infection (30.2%). | 2020-04-14 |
| 32271947 | Few case reports and clinical series exist on pregnant women infected with SARS-CoV-2 who delivered. […] The following was extracted: author; country; number of women; study design; gestational age at delivery; selected clinical maternal data; mode of delivery; selected neonatal outcomes. | 2020-04-09 |
| 32271993 | In this retrospective cohort study we analyzed the relationship between clinical characteristics, including body mass index (BMI), and the requirement for invasive mechanical ventilation (IMV) in 124 consecutive patients admitted in intensive care for SARS-CoV-2, in a single French center. | 2020-04-10 |
| 32272080 | Streamlining of workflows for rapid diagnosis and isolation, clinical management, and infection prevention will matter not only to patients with COVID-19, but also to health-care workers and other patients who are at risk from nosocomial transmission. | 2020-04-09 |
| 32272173 | We also provide a supplemental file containing background information on the biology, epidemiology, and clinical features of all human-infecting coronaviruses, along with a phylogenetic tree of these coronaviruses. | 2020-04-09 |
| 32272262 | Detailed clinical data, chest HRCT basic performances and certain signs were recorded, and ground-glass opacity (GGO), consolidation, fibrosis and air trapping were quantified. […] Both clinical types and CT stages were evaluated. […] Fever and cough were main symptoms. […] Clinical performances of patients with COVID-19, mostly with epidemiologic history and typical symptoms, were critical valuable in the diagnosis of the COVID-19. | 2020-04-11 |
| 32272480 | 0.4%; p < 0.01), and obsessive-compulsive symptoms (5.3 vs. […] They also had higher total scores of ISI, GAD-2, PHQ-2, and SCL-90-R obsessive-compulsive symptoms (p ≤ 0.01). […] Among medical health workers, having organic disease was an independent factor for insomnia, anxiety, depression, somatization, and obsessive-compulsive symptoms (p < 0.05 or 0.01). […] Living in rural areas, being female, and being at risk of contact with COVID-19 patients were the most common risk factors for insomnia, anxiety, obsessive-compulsive symptoms, and depression (p < 0.01 or 0.05). […] Among nonmedical health workers, having organic disease was a risk factor for insomnia, depression, and obsessive-compulsive symptoms (p < 0.01 or 0.05). | 2020-04-09 |
| 32272481 | In order to rapidly discover lead compounds for clinical use, we initiated a program of combined structure-assisted drug design, virtual drug screening and high-throughput screening to identify new drug leads that target the COVID-19 virus main protease (Mpro). […] Next, through a combination of structure-based virtual and high-throughput screening, we assayed over 10,000 compounds including approved drugs, drug candidates in clinical trials, and other pharmacologically active compounds as inhibitors of Mpro. […] Our results demonstrate the efficacy of this screening strategy, which can lead to the rapid discovery of drug leads with clinical potential in response to new infectious diseases for which no specific drugs or vaccines are available. | 2020-04-09 |
| 32272857 | Tissue engineering has the potential for critical impact on clinical outcomes in viral outbreaks. | 2020-04-15 |
| 32273156 | Thus, the aim of this article is to provide a brief overview of the epidemiology, symptoms, and routes of transmission of this novel infection. | 2020-04-14 |
| 32273245 | Where the availability of local clinical care is restricted, practitioners could consider advising patients to reduce or eliminate sleeping in their CL (where patients have the appropriate knowledge about correct daily care and access to suitable lens-care products) or consider the option of moving patients to daily disposable lenses (where patients have appropriate lens supplies available). […] Patients should also avoid touching their face, including their eyes, nose and mouth, with unwashed hands and avoid CL wear altogether if unwell (particularly with any cold or flu-like symptoms). | 2020-04-13 |
| 32273253 | Based on the method of evidence-based pharmacy, clinical evidence of therapeutical drugs for COVID-19 were retrieved and summarized. […] Based on clinical experience Chinese hospital pharmacists gained from providing pharmaceutical care services during COVID-19 pandemic, taking COVID-19 hospitalized patients’ needs into consideration, the methods and strategies hospital pharmacists shall use to provide pharmaceutical care were analyzed and summarized. | 2020-04-13 |
| 32273490 | Clinical features of COVID-19 in children include fever and cough, but a large proportion of infected children appears to be asymptomatic and may contribute to transmission. | 2020-04-10 |
| 32274341 | The clinical features and outcomes of Chinese patients with COVID-19 have been widely reported. […] The clinical, pathological and laboratory characteristics as well as underlying pathophysiology and etiology of liver injury in COVID-19 remain largely unclear. | 2020-04-13 |
| 32274342 | Based on the current evidence from case reports and case series, this review article focuses on the demographic and clinical characteristics, potential mechanisms, and treatment options for COVID-19-related liver dysfunction. | 2020-04-13 |
| 32274617 | Here, we briefly review the virus, its structure and evolution, epidemiology and pathogenesis, immunogenicity and immune, and clinical response in older adults, using available knowledge on SARS-CoV-2 and its highly pathogenic relatives MERS-CoV and SARS-CoV-1. […] We conclude by discussing clinical and basic science approaches to protect older adults against this disease. | 2020-04-10 |
| 32274771 | We sought to provide a clinical practice protocol for our labor and delivery (L&D) unit, to care for confirmed or suspected COVID-19 patients requiring cesarean delivery. | 2020-04-10 |
| 32274773 | In about 20% of patients, severe symptoms occur after a mean incubation period of 5 - 6 days; 5% of patients need intensive care therapy. | 2020-04-13 |
| 32274774 | In the meantime, the clinical course and outcome of some COVID-19 patients with an existing pregnancy or peripartum courses have been reported. | 2020-04-13 |
| 32274787 | We have recently observed several clusters of psychiatric symptoms in the context of COVID-19: (1) increased anxiety in psychiatric in- and outpatients with different diagnoses; (2) more cases of domestic violence often associated with increased drug- or alcohol-consumption in offenders and victims; (3) a nihilistic “apocalyptic” syndrome of elderly patients cut-off from their families; (4) visual and acoustic hallucinoses due to pneumonia and sepsis-related confusional states. | 2020-04-10 |
| 32274879 | The urology residents do not have the opportunity to carry out clinical activities nor to be tutored, as the senior physicians are engaged in the emergency’s management. | 2020-04-10 |
| 32275074 | Here were reported clinical features of silent infected COVID-19 patients. | 2020-04-10 |
| 32275124 | Working in a clinical laboratory is posing several safety challenges. | 2020-04-13 |
| 32275128 | The clinical data of 48 patients with suspected COVID-19 admitted in Jinhua Central Hospital from January 21, 2020 to March 20, 2020 were retrospectively analyzed. | 2020-04-13 |
| 32275257 | The novel coronavirus SARS-CoV-2 (Covid-19), spreading from Wuhan, China, is one of the causes of respiratory infections that can spread to other people through respiratory particles, and can cause symptoms such as fever, dry cough, shortness of breath, anorexia, fatigue and sore throat in infected patients. | 2020-04-15 |
| 32275258 | Early available clinical data have indicated that geriatric persons cum those with comorbidity such as cardiovascular, metabolic and immunological disorders suffered severe form of COVID-19. | 2020-04-15 |
| 32275259 | So, this review aims at understanding the new scenario of SARS-CoV-2 outbreak and compares the epidemiology, clinical presentations, and the genetics of these coronaviruses. | 2020-04-15 |
| 32275288 | Several studies have described typical clinical manifestations including fever, cough, diarrhea, and fatigue. […] Clinical data were extracted from electronic medical records, and data of all neurologic symptoms were checked by 2 trained neurologists. […] Compared with patients with nonsevere infection, patients with severe infection were older, had more underlying disorders, especially hypertension, and showed fewer typical symptoms of COVID-19, such as fever and cough. | 2020-04-14 |
| 32275347 | We describe the first case of acute cardiac injury directly linked to myocardial localization of severe acute respiratory syndrome coronavirus (SARS-CoV-2) in a 69-year-old patient with flu-like symptoms rapidly degenerating into respiratory distress, hypotension, and cardiogenic shock. | 2020-04-11 |
| 32275452 | We compared the clinical characteristics, laboratory examinations, CT images and treatment of COVID-19 patients from three different cities in China. 476 patients were recruited from Jan 1 to Feb 15, 2020 at three hospitals in Wuhan, Shanghai and Anhui. | 2020-04-10 |
| 32275740 | The emphasis is on maintaining clinical efficacy and safety by increasing the dose per fraction while reducing the number of daily treatments. […] The guidance is informed by adhering to acceptable radiobiological parameters and clinical tolerability. | 2020-04-10 |
| 32275766 | This narrative review provides a summary of evidence and clinical guidance for the use and interpretation of lung ultrasound for patients with moderate, severe and critical COVID-19 associated lung injury. […] Mechanisms by which the potential lung ultrasound workforce can be deployed are explored, including a pragmatic approach to training, governance, imaging, interpretation of images and implementation of lung ultrasound into routine clinical practice. | 2020-04-10 |
| 32275784 | Evidence strongly supports that access to specialty gastroenterology or hepatology care in cirrhosis is associated with higher adherence to guideline-recommended care and improves clinical outcomes. […] Telemedicine, defined as the delivery of health care services at a distance using electronic means for diagnosis and treatment, holds tremendous promise to increase access to broadly specialty care. | 2020-04-10 |
| 32275792 | The common symptoms include a dry continuous cough, fever and shortness of breath; severe cases involve pneumonia which may require ventilatory support. | 2020-04-10 |
| 32275805 | This perspective article draws on qualitative data from a longitudinal, ethnographic study of an Australian tertiary ED to illustrate the clinical and ethical challenges faced by EDs during PHEs. | 2020-04-10 |
| 32275812 | This report is based on data from patients who received remdesivir during the period from January 25, 2020, through March 7, 2020, and have clinical data for at least 1 subsequent day. […] In this cohort of patients hospitalized for severe Covid-19 who were treated with compassionate-use remdesivir, clinical improvement was observed in 36 of 53 patients (68%). | 2020-04-10 |
| 32275914 | Type 1 interferons have a broad antiviral activity in vitro and are currently evaluated in a clinical trial to treat MERS-CoV. […] In this review, we discuss preliminary data concerning the potential activity of type 1 interferons on SARS-CoV-2, and the relevance of evaluating these molecules in clinical trials for the treatment of COVID-19. | 2020-04-16 |
| 32275978 | Fourteen key questions, corresponding to 11 decision points within the three scenarios and three additional clinical situations, were rated by the panel based upon the anticipated value of the information that thoracic imaging would be expected to provide. | 2020-04-16 |
| 32276095 | The present study aims to investigate the symptoms and causes of SSD of ICU nurses treating COVID-19 pneumonia. […] Exploratory factor analysis was performed to cluster the symptoms, and logistic regression analysis to find the risk factors of the symptoms. […] Five major symptoms were chest-discomfort-and-palpitation (31.4%), dyspnea (30.7%), nausea (21.4%), headache (19.3%), and dizziness (17.9%). […] In exploratory factor analysis, the symptoms were classified into three clusters: Cluster A of breathing and sleep disturbances (dizziness, sleepiness, dyspnea); Cluster B of gastrointestinal complaints and pain (nausea, headache), and Cluster C of general symptoms (xerostomia, fatigue, chest-discomfort-and-palpitation). | 2020-04-13 |
| 32276099 | We implement thorough screening for COVID-19 symptoms at multiple levels before a patient is seen by a designated provider. […] We recommend active triaging, communication, frequent screening for COVID-19 symptoms for palliative care patients been evaluated in the community setting. | 2020-04-12 |
| 32276102 | Symptom management and skilled communication with patients and families are essential clinical services in the midst of the COVID-19 pandemic. […] It is imperative that all clinicians responding to the COVID-19 crisis have access to clinical tools to support symptom management and difficult patient and family communication. | 2020-04-13 |
| 32276116 | To describe the availability of this method in clinical diagnosis, we collected 130 specimens from patients with clinically suspected SARS-CoV-2 infection. […] These results demonstrate that we developed a rapid, simple, specific, and sensitive RT-LAMP assay for SARS-CoV-2 detection among clinical samples. | 2020-04-13 |
| 32276137 | Among the virus-contracted hosts, their different metabolic status, as determined by their diet, nutrition, age, sex, medical conditions, lifestyle, and environmental factors, govern the personal fate toward different clinical severity of COVID-19, from asymptomatic, mild, moderate, to death. | 2020-04-13 |
| 32276139 | Here, we report a familial cluster of COVID-19 where a 47-year-old woman with long-term use of glucocorticoids did not develop any symptoms within the 14-day quarantine period but was confirmed with COVID-19 by tested positive of antibody on day 40 after she left Wuhan. | 2020-04-16 |
| 32276196 | Furthermore, as compared to the non-clinical staff, front line medical staff with close contact with infected patients, including working in the departments of respiratory, emergency, infectious disease, and ICU, showed higher scores on fear scale, HAMA and HAMD, and they were 1.4 times more likely to feel fear, twice more likely to suffer anxiety and depression. | 2020-04-16 |
| 32276282 | The novel coronavirus disease 2019 (COVID-19) is spreading fast and is affecting the clinical workers at much higher risk than the general population. | 2020-04-10 |
| 32276333 | In a containment-based strategy, rapid, sensitive and specific testing is important in epidemiological control and clinical management. […] Evaluation of the new assay using 59 clinical specimens from 14 confirmed cases showed 100% concordance with our previously developed COVID-19-RdRp/Hel reference assay. | 2020-04-13 |
| 32276848 | Epidemiological, clinical, laboratory, and radiological characteristics and treatment data were collected. | 2020-04-14 |
| 32277018 | From an ethical perspective, the novelty of the current emergency is not grounded in the devastating effects of scarce resources allocation, which is rife in recent and present clinical practice. | 2020-04-11 |
| 32277203 | Major and rapid reorganisation of both clinical and support services is not straightforward. | 2020-04-15 |
| 32277351 | Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). | 2020-04-11 |
| 32277367 | • Although preliminary results may be encouraging, high-quality clinical trials are needed to better understand the role of drugs commonly used in rheumatology like hydroxychloroquine and tocilizumab in COVID-19. | 2020-04-11 |
| 32277387 | In this article, we reviewed the clinical aspects of 2019-nCoV infection, characteristics of liver transplant recipients, immunosuppressant usage, and potential drug interactions to provide recommendations to clinical staff managing liver transplant recipients during the COVID-19 epidemic. | 2020-04-11 |
| 32277408 | A 63-year-old male was admitted with pneumonia and cardiac symptoms. | 2020-04-11 |
| 32277555 | The clinical course of patients remains to be fully characterized, clinical presentation ranges from asymptomatic infection to acute respiratory distress syndrome and acute renal failure，no pharmacological therapies of proven efficacy yet exist. […] Further data are needed to achieve better understanding of the impact of immunosuppressive therapy on the clinical presentation, severity and outcome of SARS-CoV-2 infections in solid organ transplant recipients. | 2020-04-11 |
| 32277591 | Liver injury is common in patients with COVID-19, but little is known about its clinical presentation and severity in the context of liver transplantation. […] The patient came to clinic with symptoms of respiratory disease; pharyngeal swabs for severe acute respiratory syndrome coronavirus 2 were positive. | 2020-04-11 |
| 32277751 | In patients who reported other symptoms, 51% reported either cough or fever and therefore met current guidelines for self-isolation. […] Anosmia is reported in conjunction with well-reported symptoms of coronas virus, but 1 in 6 patients with recent onset anosmia report this as an isolated symptom. | 2020-04-11 |
| 32277759 | Finally, the dissociation between upper and lower respiratory tract results underscores the need for close monitoring of the clinical evolution of suspect Covid-19 cases. | 2020-04-11 |
| 32277763 | Clinical care must be provided to help our patients in a timely manner, while keeping them, health care personnel and the community safe. […] However, each referral must be reviewed on a case-by-case basis, and the clinical situation will evolve over time, necessitating flexibility in managing EDX triaging. | 2020-04-11 |
| 32277836 | The clinical course of the immunocompromised partner was benign, without need of intensive care. | 2020-04-16 |
| 32277967 | All patients completed at least twice laboratory data collection and clinical condition assessment at three time points indicated for this study; The length of hospital stay was longer than 14 days prior to February 26, 2020. | 2020-04-14 |
| 32278065 | Here we investigate the epidemiology, clinical presentation, molecular mechanisms, management, and prevention of SARS-CoV-2 associated diarrhea. […] Clinical studies show an incidence rate of diarrhea ranging from 2% to 50% of cases. […] It may precede or trail respiratory symptoms. | 2020-04-13 |
| 32278175 | Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and common flu; the probable mechanism behind the infection and its immune response. | 2020-04-16 |
| 32278670 | Symptoms began a median of 7 [5-12] days before ICU admission. | 2020-04-14 |
| 32278693 | In the present study, 61 molecules that are already being used in clinics or under clinical scrutiny as antiviral agents are surveyed via docking study. | 2020-04-12 |
| 32278716 | In the midst of a global pandemic of a novel infectious disease, reality-based considerations comprise an important starting point for formulating clinical management pathways. | 2020-04-12 |
| 32278725 | The decision to proceed with Medically-Necessary, Time-Sensitive (MeNTS) procedures in the setting of the COVID-19 pandemic requires incorporation of factors (resource limitations, COVID-19 transmission risk to providers and patients) heretofore not overtly considered by surgeons in the already complicated processes of clinical judgment and shared decision-making. | 2020-04-16 |
| 32278764 | We searched for articles in PubMed and Google Scholar databases till 02 April 2020, with the following keywords: “SARS-CoV-2”, “COVID-19”, “infection”, “pathogenesis”, “incubation period”, “transmission”, “clinical features”, “diagnosis”, “treatment”, “diabetes”, with interposition of the Boolean operator “AND”. […] The clinical spectrum of COVID-19 is heterogeneous, ranging from mild flu-like symptoms to acute respiratory distress syndrome, multiple organ failure and death. […] Further research regarding this relationship and its clinical management is warranted. | 2020-04-16 |
| 32278766 | Clinical pharmacists’ routine task is carrying out pharmaceutical care to ensure patients’ safe and reasonable medication use. […] However, under public health emergencies, such as the outbreak of COVID-19, the work strategies of clinical pharmacists need to be modified according to the rapid spread of the disease, where information and resources are usually lack to guide them. […] To retrieve and investigate the prevention and control measures of clinical pharmacists during the outbreak of novel coronavirus, summarize the roles and responsibilities of clinical pharmacists, and to propose innovative strategies for developing pharmacy services under the epidemic. […] The Chinese and English databases, self-media network, website of professional society or medical institution, and clinical trial center platforms were searched, and clinical pharmacists involved in the work against COVID-19 were surveyed and interviewed. […] Clinical pharmacists play a vital role in leading the industry to formulate work instructions, provide frontline medical staff with drug information, and develop innovative pharmacy services to promote the rational use of medicines with collaborative teamwork and close communication according to the epidemic situation of COVID-19. […] Facing public health emergencies, clinical pharmacists can give full play to their professional expertise, analyze the current situation rationally, formulate telehealth strategies swiftly, and work in a united and efficient manner to provide innovative pharmacy services to ensure medication safety and rational use of medicine. | 2020-04-12 |
| 32278865 | The risk of anxiety/depression is associated to SARS-CoV-2 pandemia and to patients’ fragility, and not to related clinical conditions associated with Common Variable Immune Deficiencies. | 2020-04-12 |
| 32279081 | In this study, we aimed to describe the clinical course and outcomes of older patients with COVID-19. […] Common symptoms of older patients with COVID-19 included fever (94.5%; n=52), dry cough (69.1%; n=38), and chest distress (63.6%; n=35). […] In the recent outbreak of COVID-19, our local hospital in Wuhan found that patients aged 65 and older had greater initial comorbidities, more severe symptoms, and were more likely to experience multi-organ involvement and death, as compared with younger patients. | 2020-04-12 |
| 32279115 | To characterize the chest computed tomography (CT) findings of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) according to clinical severity. […] This was a retrospective analysis of the clinical and thoracic CT features of 120 consecutive patients with confirmed SARS-CoV-2 pneumonia admitted to a tertiary university hospital between January 10 and February 10, 2020, in Wuhan city, China. […] The clinical and CT features at admission may enable clinicians to promptly evaluate the prognosis of patients with SARS-CoV-2 pneumonia. […] • The clinical features and predominant patterns of abnormalities on CT for asymptomatic, typic common, and severe cases were summarized. | 2020-04-12 |
| 32279318 | Further, this individual’s local health department has a protocol for identifying people who have been in direct contact with anyone testing positive for Covid-19 (such as this Prestigious University staff member) so that they can self-quarantine and watch for COVID-19 symptoms for a period of 14 days from their last contact with the infected individual. | 2020-04-12 |
| 32279418 | For this reason, clinical manifestations may differ from general population and different treatment approaches may be needed. […] Initial symptoms were fatigue, dry cough and coryza; she never had fever nor oxygen supplementation. […] The peculiarity of clinical presentation and the management difficulties represent the flagship of our case-report. | 2020-04-12 |
| 32279441 | Rapid spread of the SARS-CoV-2 virus and concern for viral transmission by ambulatory patients with minimal to no symptoms underline the importance of identifying early or subclinical symptoms of Covid-19 infection. […] Two such candidate symptoms include anecdotally reported loss of smell and taste. […] A single-institution, cross-sectional study evaluating patient-reported symptoms with a focus on smell and taste was conducted using an internet-based platform on adult subjects who underwent testing for Covid-19. […] Logistic regression was employed to identify symptoms associated with Covid-19 positivity. […] A total of 1480 patients with influenza-like symptoms underwent Covid-19 testing between March 3 through 29, 2020. […] Of patients who reported Covid-19-associated loss of smell, 74% (28/38) reported resolution of anosmia with clinical resolution of illness. […] In ambulatory individuals with influenza-like symptoms, chemosensory dysfunction was strongly associated with Covid-19 infection and should be considered when screening symptoms. […] Most will recover chemosensory function within weeks paralleling resolution of other disease-related symptoms. | 2020-04-12 |
| 32279934 | The authors have presented a protocolized approach that uses diagnostic criteria to clearly define benchmarks from the medical history along with clinical symptoms and laboratory tests. | 2020-04-16 |
| 32280058 | However, to cope with the current emergency crisis, its aim is to promptly and pragmatically implement nutritional care in patients with COVID-19, which might be overlooked despite being potentially beneficial to clinical outcomes and effective in preventing the consequences of malnutrition in this patient population. | 2020-04-13 |
| 32280076 | To evaluate the clinical and computed tomographic (CT) features in the patients with COVID-19 pneumonia confirmed by the real-time reverse transcriptase polymerase chain reaction (rRT-PCR) amplification of the viral DNA from a sputum sample. […] Clinical information and CT findings of a total of 14 patients with COVID-19 infection (age range, 12-83 years; females 6) were analyzed retrospectively. […] The clinical information includes the history of exposure, laboratory results, and the symptoms (such as fever, cough, headache, etc.) […] Seven patients had fever, 7 had cough, 2 had headache, 3 had fatigue, 1 had body soreness, 3 had diarrhea, and 2 had no obvious symptoms. […] The radiologists should know these CT findings and clinical information, which could help for accurate analysis in the patients with 2019 novel coronavirus infection. | 2020-04-13 |
| 32280993 | This article reports the prevalence and clinical presentation of PICS and provides recommendations for physical examination and outcomes measures, plan of care, and intervention strategies. | 2020-04-13 |
| 32281052 | In this regard, mesenchymal stem cells (MSCs)-based immunomodulation treatment has been proposed as a suitable therapeutic approach and several clinical trials have begun. […] Recently, MSCs according to their immunomodulatory and regenerative properties attract attention in clinical trials. […] Given the uncertainties in this area, we reviewed reported clinical trials and hypotheses to provide useful information to researchers and those interested in stem cell therapy. […] However, currently, there are no approved MSC-based approaches for the prevention and/or treatment of COVID-19 patients but clinical trials ongoing. | 2020-04-13 |
| 32281114 | A previously healthy 40 year-old male was admitted to the hospital three days after the onset of coronavirus disease 2019 (COVID-19) symptoms, including dry cough, fever, and shortness of breath progressing to intubation and increased mechanical ventilator support. | 2020-04-13 |
| 32281213 | PubMed, EMBASE, ClinicalTrials.gov, ICTRP, and Cochrane Library databases were searched for studies that evaluated the prophylactic role of CQ or HCQ on SARS-CoV-2 (pre-clinical studies) or COVID-19 (clinical studies) until 30 March 2020. […] A total of 45 articles were screened and five (three in vitro pre-clinical studies and two clinical opinions) were included. […] The pre-clinical studies showed the prophylactic effects of CQ and HCQ against SARS-CoV-2. […] On the other hand, the clinical opinions advocated the prophylactic use of CQ and HCQ against COVID-19. […] However, no original clinical studies on the prophylactic role of CQ or HCQ on COVID-19 were available. […] Although pre-clinical results are promising, till date, there is dearth of evidence to support the efficacy of CQ or HCQ in preventing COVID-19. | 2020-04-13 |
| 32281214 | In this proposal, we detail the specific protocol changes that our EP department has adopted during the COVID-19 pandemic, including performance of only urgent/emergent procedures, afterhours/7-day per week laboratory operation, single attending-only cases to preserve PPE, appropriate use of PPE, telemedicine and video chat follow-up appointments, and daily conferences to collectively manage the clinical and ethical dilemmas to come. | 2020-04-13 |
| 32281231 | Frontline physicians need to be given leeway to decide on the disposition of cases based on clinical suspicion during an ongoing outbreak of COVID-19. | 2020-04-13 |
| 32281268 | HCov-229E is one of the four flu-causing coronaviruses which share great sequence similitude, while many symptoms of patients infected with COVID-19 resemble those of patients infected with these known flu-causing coronaviruses.2 A previous study reported that human lung epithelial A549 cells treated with glucose 6-phosphate dehydrogenase (G6PD) interfering RNA (RNAi) to lower G6PD activity displayed augmented (12-fold) viral production in comparison to normal counterparts when infected with coronavirus HCov-229E. | 2020-04-13 |
| 32281327 | Taking full advantage of the clinical experience of traditional Chinese medicine(TCM) in preventing and controlling major epidemics such as SARS, it is an important mission for TCM to propose effective formula with immediate response and solid evidence by using modern biomedical knowledge and techniques(molecular docking assisted TCM formulation for short). […] In view of the high homology between the gene sequences of the novel coronavirus and SARS virus, and the similarities between the two in terms of pathogenic mechanism and clinical manifestations, our team established a rapid screening and optimization model for the prevention and treatment of the novel coronavirus based on clinical experience and molecular docking technology. […] Firstly, the clinical team and the research team pre-developed and screened TCM formula by using "back-to-back" manner. […] The result was largely consistent with the formula raised by the clinical group, verifying and supporting its rationality. […] This provides evidence for the scientific and potential efficacy of the TCM prescription from the perspective of treatment target analysis, and also suggests that the TCM prescription has the potential to directly inhibit viral infection in addition to improving clinical symptoms or syndromes. […] Based on this, our team optimized and formed a new anti-coronavirus TCM prescription "Keguan Yihao", immediately providing the TCM prescription with certain clinical experience and objective evidence support for the prevention and treatment of new emergent infectious diseases in our hospital. […] The TCM prescription was combined with modern medicine symptomatic supportive treatment for clinical treatment, preliminary results showed better effect than symptomatic supportive therapy alone. […] This research has innovated the method mode in clinical practice and basic research integration of traditional Chinese medicine for the prevention and control of new emerging infectious diseases. | 2020-04-14 |
| 32281329 | This study intends to provide reference for clinical use of traditional Chinese medicine to resist new coronavirus. | 2020-04-14 |
| 32281330 | To analyze the registered clinical trial protocols of traditional Chinese medicine(TCM) for the prevention and treatment of coronavirus disease 2019(COVID-19), in order to provide information for improving the quality of research design. […] The website of the Chinese Clinical Trial Registry(www.chictr.org.cn) and the American Clinical Trial Registry(clinicaltrials.gov) were searched to collect protocols of TCM for COVID-19. […] A total of 49 clinical trial protocols of TCM for COVID-19 were included. […] The primary evaluation outcomes mainly included antipyretic time, clinical symptom relief, novel coronavirus nucleic acid turning to negative, conversion rate of severe cases and chest CT. […] There was a quick response of clinical research on the prevention and treatment of COVID-19 with TCM, with the current registered protocols covers the whole process of disease prevention, treatment and rehabilitation. | 2020-04-14 |
| 32281331 | To investigate the regularity of prescription and clinical syndromes by analyzing the diagnosis and treatment protocols of traditional Chinese medicine(TCM) for coronavirus disease 2019(COVID-19), so as to provide references for syndrome differentiation and relevant researches. | 2020-04-14 |
| 32281333 | Staged medication and local conditions need attention during the identification and treatment of COVID-19 clinical syndromes. | 2020-04-14 |
| 32281334 | This article will introduce the TCM cognition of the COVID-19, analyze the clinical application of Chinese medicine and the entry point of pharmaceutical care, and clarify that clinical Chinese pharmacists can participate in making medication therapy plan, medication reconciliation, and prescription review, promoting rational drug use, pharmaceutical monitoring, and drug risk management. […] The participation of clinical Chinese pharmacists in the prevention and treatment of COVID-19 is conducive to improving the level of rational use of TCM, by ensuring the effectiveness, and safety. | 2020-04-14 |
| 32281335 | The advantages of traditional Chinese medicine(TCM) in treating SARS and MERS are that it can intervene and block the progression of disease in early stage, significantly reduce symptoms, shorten the treatment duration of patients, reduce complications and side effects caused by hormone therapy. […] Chinese patent medicines and prescriptions in medical observation and clinical treatment were recommended in the "pneumonia diagnosis and treatment plan for new coronavirus infection"(trial version fifth) of the National Health Commission of the People’s Republic of China. […] TCM shows good clinical efficacy and great potential in the treatment of COVID-19. […] In this paper, we reviewed traditional Chinese medicines and its active ingredients in the hope of bringing novel inspirations to the drug screening and clinical treatment for COVID-19. | 2020-04-14 |
| 32281583 | Increasing evidence obtained from completed clinical studies indicates the prospects for chloroquine/hydroxychloroquine to treat COVID-19. […] More randomized control clinical studies are warranted to determine the feasibility of these two drugs in treating COVID-19. | 2020-04-13 |
| 32281653 | Ajay Kumar Mishra and his colleagues for their attention to our review.1, 2 We strongly agree with them that it is inappropriate for COVID-19 patients to discontinue ACEIs /ARBs without weighing up the pros and cons.3, 4 Whether the RAAS inhibitors may affect the prognosis of COVID-19 patients still needs more clinical trials to confirm. | 2020-04-13 |
| 32281667 | " 1 which report the clinical features, diagnosis and treatment of the novel Coronavirus Disease 2019 (COVID-19). | 2020-04-13 |
| 32281668 | Clinical parameters were collected from electronic medical records. | 2020-04-13 |
| 32281689 | Given these risks, all major GI societies have called for rescheduling elective non-urgent procedures and perform only emergent or urgent based on the clinical need. | 2020-04-13 |
| 32281695 | To quickly guide the clinical treatment of 2019-nCoV, we searched currently available drugs that are agonists of TAS2Rs. […] We identified many cheap, available, and safe medicines, such as diphenidol, quinine, chloroquine, artemisinin, chlorpheniramine, yohimbine, and dextromethorphan, which may target the most common symptoms caused by 2019-nCoV. | 2020-04-13 |
| 32281755 | After an overview of the clinical conditions of the 7 patients positive to the virus hospitalised in the following few days, they describe in some detail how symptomatic Covid+ patients are currently managed at the Ospedale Maggiore in Lodi. | 2020-04-16 |
| 32281756 | Roberto Scarpioni and colleagues recount their experience with the Covid-19 epidemic at the Nephrology and Dialysis Center of the “Guglielmo da Saliceto” Hospital in Piacenza, where everybody is still fighting to this moment to contain the spread of the disease and face an increasingly unsustainable clinical situation. | 2020-04-16 |
| 32281757 | Covid-19 is a disease caused by a new coronavirus presenting a variability of flu-like symptoms including fever, cough, myalgia and fatigue; in severe cases, patients develop pneumonia, acute respiratory distress syndrome, sepsis and septic shock, that can result in their death. […] In patients with full-blown symptoms, there is a renal impairment of various degrees in 100% of the subjects observed. | 2020-04-16 |
| 32281785 | In this work, a dual-functional plasmonic biosensor combining the plasmonic photothermal (PPT) effect and localized surface plasmon resonance (LSPR) sensing transduction provides an alternative and promising solution for the clinical COVID-19 diagnosis. | 2020-04-16 |
| 32282022 | Given the rapid pace of scientific discovery and clinical data generated by the large number of people rapidly infected by SARS-CoV-2, clinicians need accurate evidence regarding effective medical treatments for this infection. […] Current clinical evidence does not support stopping angiotensin-converting enzyme inhibitors or angiotensin receptor blockers in patients with COVID-19. […] The speed and volume of clinical trials launched to investigate potential therapies for COVID-19 highlight both the need and capability to produce high-quality evidence even in the middle of a pandemic. | 2020-04-13 |
| 32282038 | With several vaccine candidates already being tested in clinical trials, we pose the question: what will the vaccine hesitant do in the face of this pandemic? | 2020-04-14 |
| 32282312 | We describe a case of COVID-19 pneumonia requiring hospitalization that presented with fever and extensive rash as the primary presenting symptoms. | 2020-04-13 |
| 32282371 | That same day, a skilled nursing and rehabilitation facility in the county reported that several of its residents tested positive for SARS-CoV-2 and that many staff had symptoms compatible with COVID-19. […] Tapping into the multipronged mission areas of academic medicine, UW Medicine worked to support the community, innovate in science and clinical practice, lead policy and practice guideline development, and adopt changes as the crisis unfolded. | 2020-04-13 |
| 32282372 | The author of this Invited Commentary anticipates that at least some of these innovations will become part of academic medicine’s everyday clinical and educational operations. […] Here he considers the implications of exemplary innovations-virtual care, hospital at home, advances in diagnosis and therapy, virtual learning, and virtual clinical learning-for regulators, academic medical centers, faculty, and students. | 2020-04-13 |
| 32282373 | Given this change, medical students nationwide had to grapple with how and where they could fill the evolving needs of their schools’ affiliated clinical sites, physicians, and patients and the community. […] The HMS student volunteers joined any of the 4 virtual committees to complete this work: Education for the Medical Community, Education for the Broader Community, Activism for Clinical Support, and Community Activism. | 2020-04-13 |
| 32282440 | Empirical case projection study MAIN OUTCOMES AND MEASURES:: Adjusted pediatric severity proportions and adjusted pediatric criticality proportions were derived from clinical and spatiotemporal modelling studies of the COVID-19 epidemic in China for the period Jan-Feb 2020. | 2020-04-13 |
| 32282441 | This article provides evidence-based recommendations and measures for the appropriate personal protective equipment for different clinical and surgical activities in various settings. | 2020-04-14 |
| 32282502 | No established treatment is currently available; however, several therapies, including remdesivir, hydroxychloroquine and chloroquine, and interleukin (IL)-6 inhibitors, are being used off-label and evaluated in ongoing clinical trials. | 2020-04-13 |
| 32282894 | Urgent clinical and public health needs currently drive an unprecedented global effort to increase testing capacity for SARS-CoV-2 infection. | 2020-04-13 |
| 32282974 | As ethical expertise in Latin America focuses on research ethics, few hospitals in the region have functioning clinical ethics committees or clinical ethics policy, forcing healthcare personnel to make excruciating treatment decisions in an environment dominated by material scarcity and public distrust. | 2020-04-14 |
| 32282982 | To understand the impact on transplant activity across the US, and center-level variation in testing, clinical practice, and policies, we conducted a national survey between March 24-31, 2020 and linked responses to the COVID-19 incidence map. […] There is wide heterogeneity in center-level response across the US; ongoing national data collection, expert discussion, and clinical studies are critical to informing evidence-based practices. | 2020-04-13 |
| 32283006 | We propose that the olfactory epithelium from the nasal cavity may be a more appropriate tissue for detection of SARS-CoV-2 virus at the earliest stages, prior to onset of symptoms or even in asymptomatic people, as compared to commonly used sputum or nasopharyngeal swabs. | 2020-04-13 |
| 32283100 | The purpose of this AGA Institute Clinical Practice Update is to rapidly review the emerging evidence and provide timely expert recommendations regarding the management of patients with inflammatory bowel disease during the COVID-19 pandemic. […] This expert commentary was commissioned and approved by the AGA Institute Clinical Practice Updates Committee (CPUC) and the AGA Governing Board to provide timely perspective on a topic of high clinical importance to the AGA membership, and underwent internal peer review by the CPUC and external peer review through standard procedures of Gastroenterology. | 2020-04-15 |
| 32283139 | Epidemiological, clinical and laboratory data of the household members were collected. […] There were 155 close contacts in total. 104 contacts received RT-PCR assays, with 47 (30%) positive cases and 57 (37%) negative cases. 51 (33%) cases did not received RT-PCR tests for they showed no symptoms of pneumonia during the 2 weeks of quarantine. | 2020-04-16 |
| 32283141 | In conclusion, serological ICG strip assay in detecting SARS-CoV-2 infection is both sensitive and consistent, which is considered as an excellent supplementary approach in clinical application. | 2020-04-13 |
| 32283143 | Lopinavir/ritonavir and arbidol have been previously used to treat acute respiratory syndrome- coronavirus 2 (SARS-CoV-2) replication in clinical practice; nevertheless, their effectiveness remains controversial. | 2020-04-13 |
| 32283146 | A Maximum likelihood tree has been built and selective pressure has been investigated in order to find any mutation developed during the SARS-CoV-2 epidemic that could potentially affect clinical evolution of the infection. | 2020-04-13 |
| 32283152 | This article reviews the occurrence mechanism and treatment strategies of the COVID-19 virus-induced inflammatory storm in attempt to provide valuable medication guidance for clinical treatment. | 2020-04-13 |
| 32283155 | Among COVID-19 patients, fever (83.3% [95% CI 78.4-87.7]), cough (60.3% [54.2-66.3]), and fatigue (38.0% [29.8-46.5]) were the most common clinical symptoms. […] Patients living in Wuhan, older patients, and those with medical comorbidities tend to have more severe clinical symptoms and higher CFR. | 2020-04-16 |
| 32283156 | His very first symptoms were itchy eyes and fever developed at noon and in the afternoon on January 22, respectively. | 2020-04-13 |
| 32283162 | Several studies have described the clinical characteristics of patients with novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19), indicating severe patients tended to have higher neutrophil to lymphocyte ratio (NLR). | 2020-04-13 |
| 32283165 | As of March 11, the fourth-generation cases had no symptoms. | 2020-04-14 |
| 32283217 | Finally, due to deterioration in the clinical and imaging findings, the patient was expired as a result of multi-organ failure. | 2020-04-16 |
| 32283220 | Our commentary provides rationale for the need to focus on family caregivers and key considerations for how to include them in pandemic clinical decision making. | 2020-04-14 |
| 32283325 | We aimed to clarify the features of COVID-19-related liver damage to provide references for clinical treatment. […] We performed a retrospective, single-center study of 148 consecutive patients with confirmed COVID-19 (73 female, 75 male; mean age, 50 years) at the Shanghai Public Health Clinical Center from January 20 through January 31, 2020. […] Patients were analyzed for clinical features, laboratory parameters (including liver function tests), medications, and length of hospital stay. | 2020-04-13 |
| 32283498 | We aimed to delineate the differences in viral dynamics and clinical features between them and tried to focus on every basic details of SARS-COV-2 (COVID-19) that every health care provider must know. […] Ample data is available to suggest the differences in etiology, transmission cycle, diagnosis, genetics, hosts, reproductive rates, clinical features, laboratory diagnosis and radiological features between SARS-CoV-1, MERS-CoV and SARS-CoV-2. | 2020-04-15 |
| 32283877 | Objective: To analyze the prognostic value of myocardial injury in patients with COVID-19. Method: Confirmed cases of COVID-19 patients admitted from January 31st to February 5th at isolation ward of Renmin Hospital of Wuhan University were divided into non-survival group and survival group according to the clinical outcomes 5 weeks after admission. | 2020-04-14 |
| 32283878 | Currently, it is commonly reported that COVID-19 patients are associated with conjunctival congestion and other symptoms, and the transmission route or high-risk diseases of ophthalmology and high-risk working status are speculated. […] Are conjunctival congestion or conjunctival related symptoms in patients with 2019 novel coronavirus definitely related the novel coronavirus? […] Conjunctival congestion is one of the common clinical signs of various types of conjunctivitis. […] The symptoms and signs of conjunctivitis in COVID-19 patients may be related to a variety of factors. […] Therefore, conjunctival symptoms should not be associated with 2019 novel coronavirus without evidence. ( Chin J Ophthalmol, 2020, 56: ). | 2020-04-14 |
| 32283980 | Pharyngodynia, nasal congestion, rhinorrhea, smell, and taste dysfunctions could be the presenting symptoms of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2. […] The aim was to perform a systematic review of current evidences on clinical presentation of COVID-19, focusing on upper airway symptoms in order to help otolaryngologists identifying suspected cases. […] We included 5 retrospective clinical studies for a total of 1556 hospitalized patients with COVID-19, 57.5% were male and mean age was 49.1 years. […] Common symptoms were fever (85.6%), cough (68.7%), and fatigue (39.4%). […] Otolaryngologists should know that pharyngodynia, nasal congestion, olfactory, and gustative disorders could be the presenting symptoms of COVID-19. […] Clinical presentation together with radiological and laboratory findings could help to identify suspected cases. | 2020-04-14 |
| 32284146 | The patient’s primary symptom was a red eye with watery discharge, though she did have mild respiratory symptoms, without fever. | 2020-04-16 |
| 32284276 | The alarming spread of the infection and the severe clinical disease that it may cause have led to the widespread institution of social distancing measures. | 2020-04-16 |
| 32284362 | In a short period of time, it has already caused reorganization of neuromuscular clinical care delivery and education, which will likely have lasting impact on the field. […] We outline key unanswered clinical questions and highlight the need for team-based and inter-specialty collaboration. […] Primary goals of clinical research during this time are to develop evidence-based best practices and to minimize morbidity and mortality related to COVID-19 for patients with neuromuscular disorders. | 2020-04-14 |
| 32284613 | We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. […] Symptoms in these cases were nonspecific and no children required respiratory support or intensive care. | 2020-04-16 |
| 32284616 | A key public health priority during the emergence of a novel pathogen is estimating clinical severity, which requires properly adjusting for the case ascertainment rate and the delay between symptoms onset and death. […] Using public and published information, we estimate that the overall symptomatic case fatality risk (the probability of dying after developing symptoms) of COVID-19 in Wuhan was 1.4% (0.9-2.1%), which is substantially lower than both the corresponding crude or naïve confirmed case fatality risk (2,169/48,557 = 4.5%) and the approximator1 of deaths/deaths + recoveries (2,169/2,169 + 17,572 = 11%) as of 29 February 2020. […] Compared to those aged 30-59 years, those aged below 30 and above 59 years were 0.6 (0.3-1.1) and 5.1 (4.2-6.1) times more likely to die after developing symptoms. | 2020-04-16 |
| 32284951 | It is important to caution readers that new data emerges daily regarding clinical characteristics, treatment options, and outcomes for COVID-19. […] Optimized supportive care remains the mainstay of therapy, and the clinical efficacy for the subsequent agents is still under investigation. […] We encourage all readers to continue to assess clinical data as it emerges and share their experience within our community in a well-controlled, adequately powered fashion. | 2020-04-16 |
| 32285222 | Three patients were imaged for non-respiratory-related symptoms with a portion of the lungs in the imaged field. | 2020-04-14 |
| 32285293 | An in-depth understanding of ACE2 and a series of physiological and physiological changes caused by the virus invading the human body may help to discover and explain the corresponding clinical phenomena and then deal with them timely. | 2020-04-14 |
| 32285380 | The aim of this study was to investigate the clinical characteristics of neonates born to SARS-CoV-2 infected mothers and increase the current knowledge on the perinatal consequences of COVID-19. […] None of the neonates developed clinical, radiologic, hematologic, or biochemical evidence of COVID-19. | 2020-04-14 |
| 32285862 | The publication of full-genomes of the newly identified coronavirus (initially called 2019-nCoV, now called SARS-CoV2) in public and private databases, of standardized diagnostic protocols and of the clinical-epidemiological information generated will allow addressing the Public Health Emergency of International Concern (PHEIC), declared on January 30 by the WHO. | 2020-04-16 |
| 32285930 | The data sources included were 1) longitudinal clinical, pharmacokinetic, and virologic data from patients with severe acute respiratory syndrome-2 (SARS-CoV-2) infection who received HCQ with or without azithromycin (n=116), 2) in vitro viral replication data and SARS-CoV-2 viral load inhibition by HCQ, 3) a population pharmacokinetic model of HCQ and 4) a model relating chloroquine pharmacokinetics to QTc prolongation. […] This prolongation may have clinical implications warranting further safety assessment. | 2020-04-14 |
| 32286091 | Data were collected from 7,236 self-selected participants measured by anxiety symptoms, depressive symptoms, and sleep quality. […] The overall prevalence of anxiety symptoms, depressive symptoms, and poor sleep quality were 35.1%, 20.1%, and 18.2%, respectively. […] People aged < 35 years reported a higher prevalence of anxiety symptoms and depressive symptoms than people aged ≥ 35 years. […] Healthcare workers/younger people who spent a high level of time (≥ 3 hours/day) had a particular higher prevalence of anxiety symptoms than in those who spent less time (< 1 hours/day and 1-2 hours/day) on the outbreak. | 2020-04-14 |
| 32286155 | We comprehensively analyzed this familial cluster of cases based on the clinical characteristics, chest CT images, SARS-CoV-2 molecular detection results, and serology testing results. | 2020-04-14 |
| 32286213 | In this case report, a 50-year-old man who had no medical history, presented with multiple cardiac arrests following a week with progressing symptoms of pneumonia. […] In conclusion: coronavirus disease 2019 (COVID-19) can lead to a fatal outcome in younger healthy residents, who are not treated timely in case of severe symptoms like dyspnoea. | 2020-04-16 |
| 32286214 | Besides the well-known symptoms of SARS-CoV-2, this case also reports total anosmia and ageusia. | 2020-04-16 |
| 32286245 | Background As coronavirus disease 2019 (COVID-19) pandemic rages on, there is urgent need for identification of clinical and laboratory predictors for progression towards severe and fatal forms of this illness. | 2020-04-14 |
| 32286678 | The clinical effect of ACEIs/ARBs on patients with COVID-19 is still uncertain. | 2020-04-14 |
| 32286679 | Human coronaviruses (HCoV) are mainly known to cause infections of the upper and lower respiratory tract but the symptoms may also involve the nervous and digestive systems. […] The most common symptoms are fever and cough, fatigue, sputum production, dyspnea, myalgia, arthralgia or sore throat, headache, nausea, vomiting or diarrhea (30%). | 2020-04-14 |
| 32286909 | This commentary provides background on the outbreak, highlights critical considerations around mitigating infectious aerosol contact, and outlines best practices for airway-related clinical decision making during the COVID-19 pandemic. | 2020-04-14 |
| 32286913 | Otolaryngology providers should maintain high clinical suspicion for mild and asymptomatic COVID-19 patients. | 2020-04-14 |
| 32286947 | In this article, we systematically review the brief history of COVID-19 and its epidemic and clinical characteristics, highlighting the strategies used to control and prevent the disease in China, which may help other countries respond to the outbreak. | 2020-04-14 |
| 32287040 | Tools that can improve the focus of surveillance efforts and clinical decision support are of paramount importance. […] HHS supports four main features: syndromic surveillance on mobile devices, policy-making decision support, clinical decision support and prioritization of resources, and follow-up of discharged patients. […] The clinical decision support component in HHS was also provided to improve patient care and prioritize the limited medical resources. […] However, the statistical methods still require further evaluations to confirm clinical effectiveness and appropriateness of disposition assigned in this study, which warrants further investigation. | 2020-04-14 |
| 32287082 | As the nation’s safety net health care systems, academic medical centers (AMCs) are vital clinical and academic resources in managing the pandemic. […] COVID-19 may also risk the financial underpinnings of AMCs because their cost structures are high, and they may have incurred large amounts of debt over the last decade as they expanded their clinical operations and facilities. | 2020-04-14 |
| 32287140 | Since the outbreak of Coronavirus Disease 2019 (COVID-19) in December 2019, various digestive symptoms have been frequently reported in patients infected with the virus. […] In this study, we aimed to further investigate the prevalence and outcomes of COVID-19 patients with digestive symptoms. […] All patients were confirmed by real-time polymerase chain reaction and were analyzed for clinical characteristics, laboratory data, and treatment. […] Although most patients presented to the hospital with fever or respiratory symptoms, we found that 103 patients (50.5%) reported a digestive symptom, including lack of appetite (81 [78.6%] cases), diarrhea (35 [34%] cases), vomiting (4 [3.9%] cases), and abdominal pain (2 [1.9%] cases). […] Patients with digestive symptoms had a significantly longer time from onset to admission than patients without digestive symptoms (9.0 days vs 7.3 days). […] In 6 cases, there were digestive symptoms, but no respiratory symptoms. […] As the severity of the disease increased, digestive symptoms became more pronounced. […] Patients with digestive symptoms had higher mean liver enzyme levels, lower monocyte count, longer prothrombin time, and received more antimicrobial treatment than those without digestive symptoms. […] We found that digestive symptoms are common in patients with COVID-19. […] Clinicians should recognize that digestive symptoms, such as diarrhea, are commonly among the presenting features of COVID-19 and that the index of suspicion may need to be raised earlier in at-risk patients presenting with digestive symptoms. | 2020-04-14 |
| 32289016 | Clinical evidence is needed in the future to evaluate the efficacy of traditional medicine. | 2020-04-16 |
| 32289038 | Based on 33 articles published by Chinese scholars, guidelines and clinical practice experience in domestic hospitals, we have summarized the Chinese experience through the lens of ophthalmology, hoping to make a contribution to protecting ophthalmologists and patients around the world. | 2020-04-16 |
| 32289263 | Compared with a clinical isolate, the infectious-clone-derived SARS-CoV-2 (icSARS-CoV-2) exhibited similar plaque morphology, viral RNA profile, and replication kinetics. | 2020-04-14 |
| 32289466 | A total of 102 patients (48 Male [47%] and 54 Female [53%]) with clinical symptoms, Rt, and chest Computed Tomography (CT) abnormalities were identified with a clinical diagnosis of COVID-19. | 2020-04-14 |
| 32289516 | Clinical information on patients contracted with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the perioperative period is limited. […] Fever, lymphopenia and ground-glass opacities on computerized tomography (CT) are the most common clinical manifestations of COVID-19 in patients after lung resection surgery. | 2020-04-14 |
| 32289548 | We conducted an uncontrolled non-comparative observational study in a cohort of 80 relatively mildly infected inpatients treated with a combination of hydroxychloroquine and azithromycin over a period of at least three days, with three main measurements: clinical outcome, contagiousness as assessed by PCR and culture, and length of stay in infectious disease unit (IDU). | 2020-04-16 |
| 32289565 | To investigate the epidemiological and clinical features of patients with COVID-19 in Anhui province of China. […] Clinical outcomes were followed up to Feb 18, 2020. […] Common symptoms include fever [116 (92.8%)], cough [102(81.6%)], and shortness of breath [57(45.6%)]. | 2020-04-16 |
| 32289791 | Using Richardson and Davidson’s model and the sciences of pharmacokinetics and clinical pharmacopsychology, this article reviewed the: (1) poor life expectancy associated with treatment-resistant schizophrenia (TRS), which may be improved in patients who adhere to clozapine; (2) findings that clozapine is the best treatment for TRS (according to efficacy, effectiveness and well-being); and (3) potential for clozapine to cause vulnerabilities, including potentially lethal adverse drug reactions such as agranulocytosis, pneumonia, and myocarditis. […] Psychiatrists should call their clozapine patients and families and explain to them that if the patient develops fever or flu-like symptoms, the psychiatrist should be called and should consider halving the clozapine dose. […] If the patient is hospitalized with pneumonia, the treating physician needs to assess for symptoms of clozapine intoxication since halving the dose may not be enough for all patients; consider decreasing it to one-third or even stopping it. | 2020-04-14 |
| 32290293 | In this article, we present a succinct overview of the epidemiology, clinical features, and molecular characteristics of SARS-CoV-2. […] We summarize the current epidemiological and clinical data from the initial Wuhan studies, and emphasize several features of SARS-CoV-2, which differentiate it from SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), such as high variability of disease presentation. […] We systematize the current clinical trials that have been rapidly initiated after the outbreak of COVID-19 pandemic. […] The initial clinical studies revealed the promising therapeutic potential of several of such drugs, including favipiravir, a broad-spectrum antiviral drug that interferes with the viral replication, and hydroxychloroquine, the repurposed antimalarial drug that interferes with the virus endosomal entry pathway. | 2020-04-16 |
| 32290348 | This short communication focuses on four treatments recommended by WHO and included in the first clinical trial of the European Discovery project. | 2020-04-15 |
| 32290644 | The objective of this work is to report the initial experience with epidemiologic and clinical features, as well as with the management of COVID-19 patients in India. […] Clinical, laboratory, and radiologic data were collected, including age, sex, nationality, travel history, symptoms, duration of stay, and comorbidities. […] The most common symptoms were fever and cough (42.9%) followed by sore throat, headache and breathlessness. […] Among the first 21 patients diagnosed with COVID-19 infection in India, the typical clinical presentation consisted in a mild upper respiratory tract infection predominantly affecting the young male population. […] All patients recovered with no residual symptoms. | 2020-04-16 |
| 32290839 | Moreover, Tocilizumab treatment that blocking IL-6 receptors showed inspiring clinical results including temperature returned to normal quickly and respiratory function improved. | 2020-04-16 |
| 32291112 | Hundreds of clinical studies have been registered with the intention of discovering effective treatments. […] Here, we review currently registered interventional clinical trials for the treatment and prevention of COVID-19 to provide an overall summary and insight into the global response. | 2020-04-15 |
| 32291137 | We propose to utilize interleukin-6 (IL-6) blockade to manage COVID-19-induced CRS and discuss several factors that should be taken into consideration for its clinical application. | 2020-04-15 |
| 32291207 | We enrolled patients with confirmed diagnosis of COVID-19 retrospectively and collected heart-related clinical data, mainly including cardiac imaging findings, laboratory results and clinical outcomes. […] The clinical evidence in our study suggested that myocardial injury is more likely related to systemic consequences rather than direct damage by the 2019 novel coronavirus. […] The elevation in cardiac markers was probably due to secondary and systemic consequences and can be considered as the warning sign for recent adverse clinical outcomes of the patients. | 2020-04-15 |
| 32291351 | There is no approved drug or vaccine for COVID-19, although more than 10 clinical trials have been launched to test potential drugs. | 2020-04-15 |
| 32291365 | In late 2019, a mass of patients showing symptoms of a pneumonia-like disease of unknown origin emerged in Wuhan, China. | 2020-04-16 |
| 32291373 | During the pandemic, physicians may need to raise the index of suspicion earlier in at-risk patients presenting with gastrointestinal symptoms, which are uncommon findings in coronavirus disease 2019 (COVID-19) patients. […] We report a patient in Indonesia with chest pain and gastrointestinal symptoms who was later confirmed to have SARS-CoV-2 infection after spending days of hospitalisation in the standard ward. | 2020-04-16 |
| 32291374 | The objective of this case study is to investigate the importance and utility of chest computed tomography (CT) in the diagnosis of COVID-19, as increasing pieces of evidence suggest that chest CT could prove useful in the clinical pathway in diagnosing COVID-19. | 2020-04-16 |
| 32291376 | COVID-19 symptom is highly various in each patient, with fever, fatigue, shortness of breath, and cough as the main presenting symptoms. | 2020-04-16 |
| 32291382 | Various challenges associated with developing a vaccine during the pandemic such as technological hurdles, clinical development pathways, regulatory issues, and support from global funding agencies are expressed here. | 2020-04-15 |
| 32291501 | This review is mainly about the differences in clinical symptom spectrum, diagnosis of COVID-19, and CT imaging findings between adults and children, while highlighting the value of radiology in prevention and control of COVID-19 in pediatric patients. […] KEY POINTS: • Compared with adults, pediatric patients with COVID-19 have the characteristics of lower incidence, slighter clinical symptoms, shorter course of disease, and fewer severe cases. | 2020-04-15 |
| 32291502 | CT images and medical records of 88 patients with confirmed mild COVID-19 pneumonia, a baseline CT, and at least one follow-up CT were retrospectively reviewed. […] The most common symptoms were fever (84.1%) and cough (56.8%). | 2020-04-15 |
| 32291505 | The majority of patients presents with mild symptoms of coronavirus disease 2019 (COVID-19). | 2020-04-15 |
| 32291542 | In this review, we summarized the epidemiological characteristics, clinical features, diagnosis, treatment, and prognosis of COVID-19. | 2020-04-15 |
| 32292012 | Objective: Todiscuss the the effects, indications and protective measures of tracheotomy for severe cases of 2019 novel corona virus disease(COVID-19)patients. Methods: A retrospectively analyze was conducted to explore the clinical data of ofCOVID-19 patients who received tracheotomy in February to March 2020,descriptive statistics were used to analyze the indication of tracheotomy, particularity of intraoperative treatment and protective measures. Results: A total of 4 cases were included in this article, 3 cases were successfully operated, 1 case of postoperative incision continuous bleeding, there were not other complications and nosocomial infection among the medical staff.the patient’s condition was relieved in different degrees after the operation, who remain hospitalized. Conclusion: Tracheotomy for severe cases of COVID-19 can achieve certain curative effect, but the occurrence of tracheotomy related complicationsand nosocomial infection should be effectively controlled, and the risk benefit ratio of tracheotomy should be carefully weighed before surgery. 目的： 探讨新型冠状病毒肺炎危重型患者施行气管切开术的指征、术中处理的特殊性及防护措施。 | 2020-04-15 |
| 32292205 | General demographic characteristics, epidemiological history, and clinical symptoms of COVID-19 were collected that had been reported on the websites of multiple Municipal Health Commissions in China. | 2020-04-15 |
| 32292213 | The clinical course of the disease known as coronavirus disease 2019 (COVID-19) ranges from mild respiratory symptoms to severe lung failure. […] Molecular diagnostic methods have been established in a very short time and a number of clinical studies on the effectiveness of different antiviral drugs are ongoing. | 2020-04-15 |
| 32292300 | Symptoms of COVID-2019 include cough, fever, and shortness of breath. […] Primary care providers must be alert to respiratory symptoms they encounter that are associated with pertinent travel history, be prepared to safely screen, examine and possibly test and/or report suspicions to the health department for further evaluation. | 2020-04-15 |
| 32292517 | The clinical outcomes were monitored up to February 11, 2020. […] Three kinds of responses to clinical treatment were defined and evaluated: 1) good, symptoms continually improved; 2) fair, symptoms not improved or relapsed; 3) poor, symptoms aggravated. […] The risk factors, including basal clinical characteristics, CT imaging features, and follow-up CT changes (no change, progress, and improvement) related to poor/fair outcomes, were also investigated. Results: Six patients were improved to no-emergency type, 2 remained the same, and 2 progressed to fatal type. […] The progression in abnormal imaging findings indicate a poor/fair response, whereas the alleviated symptoms seen from CT suggest a good response. Conclusion: Most cases are no-emergency type and have a favorable response to clinical treatment. | 2020-04-16 |
| 32292529 | We extracted the case definition and clinical classifications of COVID-19 in China along with relevant TCM treatments cited in the seventh edition of the guideline, with an intend to disseminate practical information to TCM practitioners and researchers around the world. […] We presented the most recent case definition, clinical classifications, and relevant TCM treatments of COVID-19 in accordance to recommendations of the Chinese guideline. […] Several herbal formulae are recommended for confirmed COVID-19 cases according to their clinical classification and TCM pattern diagnoses. | 2020-04-15 |
| 32292587 | The highly prevalence of COVID-19 is due to the lack onset of symptoms. […] Our study aimed to present an overview of the virus in terms of structure, epidemiology, symptoms, treatment, and prevention. | 2020-04-15 |
| 32292626 | Since its outbreak in December 2019, a series of clinical trials on Coronavirus Disease 2019 (COVID-19) have been registered or carried out. […] This study aimed to develop a core outcome set (COS) for clinical trials on COVID-19 in order to tackle the outcome issues. […] A research group was set up that included experts in respiratory and critical medicine, traditional Chinese medicine, evidence-based medicine, clinical pharmacology, and statistics, in addition to medical journal editors. […] Clinical trial registry websites (chictr.org.cn and clinicaltrials.gov) were searched to retrieve clinical trial protocols and outcomes in order to form an outcome pool. […] A total of 78 clinical trial protocols on COVID-19 were included and 259 outcomes were collected. […] After two rounds of Delphi survey and one consensus meeting, the most important outcomes for the different clinical classifications of COVID-19 were identified and determined to constitute the COS for clinical trials on COVID-19 (COS-COVID). […] The COS-COVID includes one outcome for the mild type (time to 2019-nCoV reverse transcription-polymerase chain reaction (RT-PCR) negativity), four outcomes for the ordinary type (length of hospital stay, composite events, score of clinical symptoms, and time to 2019-nCoV RT-PCR negativity), five outcomes for the severe type (composite events, length of hospital stay, arterial oxygen partial pressure (PaO2)/fraction of inspired oxygen (FiO2), duration of mechanical ventilation, and time to 2019-nCoV RT-PCR negativity), one outcome for critical type (all-cause mortality), and one outcome for rehabilitation period (pulmonary function). […] The COS-COVID is currently the most valuable and practical clinical outcome set for the evaluation of intervention effect, and is useful for evidence assessment and decision-making. | 2020-04-15 |
| 32292627 | MSCs transplant into patients with H7N9 induced ARDS were conducted in a single center and open-label clinical trial. […] Collectively, these results suggest that MSCs significantly improve survival rate of H7N9 induced ARDS and provide a theoretical basis for the treatment of H7N9 induced ARDS in both preclinical research and clinical studies. | 2020-04-15 |
| 32292633 | It is found that the existence, relatedness, and growth needs coexist in clinical nurses. | 2020-04-15 |
| 32292634 | This scientific and practical consensus guideline can provide clinical guidance on the holistic nursing care of patients with severe COVID-19. | 2020-04-15 |
| 32292686 | Along with severe acute respiratory syndrome (SARS) and Middle Eastern respiratory syndrome (MERS), COVID-19 appears to cause a severe clinical picture in humans, ranging from mild malaise to death by sepsis/acute respiratory distress syndrome. | 2020-04-15 |
| 32292689 | In addition, a database of 78 commonly used anti-viral drugs including those currently on the market and undergoing clinical trials for SARS-CoV-2 was constructed. […] This study will provide new lead compounds and targets for further in vitro and in vivo studies of SARS-CoV-2, new insights for those drugs currently ongoing clinical studies, and also possible new strategies for drug repositioning to treat SARS-CoV-2 infections. | 2020-04-15 |
| 32292802 | We have also provided information about the classification, genome, proteins, clinical presentation of COVID-19, type of clinical specimens to be collected and diagnostic methods adopted to identify the respiratory illness. […] Management of the ongoing outbreak of SARS-CoV-2 encompassing surveillance, clinical, immunological, genetic and evolutionary investigations are likely to provide the desired results. | 2020-04-15 |
| 32292826 | Since the coronavirus disease 2019 (COVID-19) outbreak was identified in December 2019 in Wuhan, China, a strong response from the research community has been observed with the proliferation of independent clinical trials assessing diagnostic methods, therapeutic and prophylactic strategies. […] While there is no intervention for the prevention or treatment of COVID-19 with proven clinical efficacy to date, tools to distil the current research landscape by intervention, level of evidence and those studies likely powered to address future research questions is essential. […] This living systematic review aims to provide an open, accessible and frequently updated resource summarising the characteristics of COVID-19 clinical trial registrations. […] Weekly search updates of the WHO International Clinical Trials Registry Platform (ICTRP) and source registries will be conducted. […] This living systematic review will provide a useful resource of COVID-19 clinical trial registrations for researchers in a rapidly evolving context. | 2020-04-15 |
| 32292837 | Adopted preventive measures and recommendations are highlighted for patients, professionals and clinical operations to minimize the risk of infection while safely treating cancer patients. | 2020-04-15 |
| 32292839 | Recommendations are provided by National Comprehensive Cancer Network (NCCN) risk group, including clinical node positive, post-prostatectomy, oligometastatic, and low volume M1 disease. […] Unfavorable intermediate-risk, high-risk, clinical node positive, recurrence post-surgery, oligometastatic, and low-volume M1 disease can receive neoadjuvant hormone therapy for 4-6 months as necessary. […] Ultrahypofractionation was preferred for localized, oligometastatic, and low volume M1, and moderate hypofractionation was preferred for post-prostatectomy and clinical node positive disease. | 2020-04-15 |
| 32292842 | In the setting of a public health emergency with the potential to strain critical healthcare resources and place patients at infection risk, the parsimonious application of breast radiotherapy may alleviate a significant clinical burden without compromising long term oncologic outcomes. | 2020-04-15 |
| 32292847 | Dealing with the immense challenge of COVID-19 disease, confronted with severely ill patients in dire straits with virtually no rigorous evidence base to guide our therapy, we must call upon our clinical skills and judgment. […] Lacking a robust evidence base, pathophysiologic reasoning can help guide our choices of therapy for individual clinical scenarios. | 2020-04-15 |
| 32292848 | We review the most current data with a focus on our basic understanding of the mechanism(s) of disease and translation to the clinical syndrome and potential therapeutics. […] We discuss the basic virology, epidemiology, clinical manifestation, multi-organ consequences, and outcomes. | 2020-04-15 |
| 32292866 | During the first phase of the disease (from onset of the symptoms up to 7-10 days) viral-induced effects are prominent with the opportunity to institute antiviral therapy. […] Furthermore, we provide some clinical and physiopathological background, as well as preliminary outcome data of our cohort, in order to better clarify the pathogenesis of the disease and clinical management. | 2020-04-15 |
| 32292880 | In order to know about the progress and prospective on imaging of COVID-19, this review focus on interpreting the CT findings, stating the potential pathological basis, proposing the challenge of patients with underlying diseases, differentiating with other diseases and suggesting the future research and clinical directions, which would be helpful for the radiologists in the clinical practice and research. | 2020-04-15 |
| 32292881 | Understanding the role of paucisymptomatic subjects and stratifying patients according to the risk of developing severe clinical presentations is pivotal for implementing reasonable measures to contain the infection and to reduce its mortality. | 2020-04-15 |
| 32292899 | We intended to describe their clinical characteristics and outcomes. […] We retrospectively analyzed the clinical data of 34 patients underwent elective surgeries during the incubation period of COVID-19 at Renmin Hospital, Zhongnan Hospital, Tongji Hospital and Central Hospital in Wuhan, from January 1 to February 5, 2020. […] Common symptoms included fever (31 [91·2%]), fatigue (25 [73·5%]) and dry cough (18 [52·9%]). 15 (44·1%) patients required admission to intensive care unit (ICU) during disease progression, and 7 patients (20·5%) died after admission to ICU. | 2020-04-15 |
| 32292901 | Mapping of the genes encoding human protein matches to pathways point to targets that could explain the observed presentation of symptoms in COVID-19 disease. | 2020-04-15 |
| 32292902 | An overt diagnosis of pneumonia was made in 91.8% and the most common symptoms were fever (82.6%), cough (57.1%) and dyspnea (27.0%). […] None of the 41 newborns assessed showed clinical signs of vertical transmission. […] There have been no published cases of clinical evidence of vertical transmission. | 2020-04-15 |
| 32292903 | Fourteen (32.6%) patients presented without any COVID-associated viral symptoms, and were identified either after developing symptoms during admission or following the implementation of universal testing for all obstetrical admissions on March 22. […] Of these, 10/14 (71.4%) developed symptoms or signs of COVID-19 infection over the course of their delivery admission or early after postpartum discharge. […] Of the other 29 (67.4%) patients who presented with symptomatic COVID-19 infection, three women ultimately required antenatal admission for viral symptoms, and an additional patient represented six days postpartum after a successful labor induction with worsening respiratory status that required oxygen supplementation. | 2020-04-15 |
| 32292904 | This report describes the clinical characteristics of COVID-19 in an in-center hemodialysis patient, as well as our experience in implementing steps to prevent the spread of COVID-19 pneumonia among in-center hemodialysis patients. | 2020-04-15 |
| 32292906 | We also propose to further explore the use of resiniferatoxin (RTX), an ultra-potent TRPV1 agonist currently in clinical trials for cancer and osteoarthritis pain, as a possible ablating agent of TRPV1 positive pulmonary pathways in patients with advanced COVID-19 disease. | 2020-04-15 |
| 32292908 | The capacity and capabilities of global producers to meet the potential demand for treating patients inflicted with COVID-19 by the novel corona virus SARS-CoV-2, should HCQ’s efficacy be established by more definitive clinical trials, is also assessed. | 2020-04-15 |
| 32293003 | We also review in detail the molecular mechanisms linking the RAS to lung damage and the potential clinical impact of treatment with RAS blockers in patients with COVID-19 and a high cardiovascular and renal risk. | 2020-04-15 |
| 32293018 | Whilst it usually takes 10-15 years to develop a vaccine, it has only taken just over 9 weeks from the publication of the viral genetic sequence for the first vaccine candidate to reach clinical testing. […] Development has been expediated by using existing technological platforms and by performing preclinical and clinical testing simultaneously. | 2020-04-16 |
| 32293020 | Coronavirus Disease 2019 (COVID-19) can cause severe respiratory failure and distressing symptoms including fever, cough, breathlessness and anxiety. | 2020-04-16 |
| 32293098 | Most patients have mild to moderate symptoms, but a subgroup will become severely ill. | 2020-04-15 |
| 32293168 | Here, we report a field-effect transistor (FET)-based biosensing device for detecting SARS-CoV-2 in clinical samples. […] Our FET device could detect SARS-CoV-2 spike protein at concentrations of 1 fg/ml in PBS and 100 fg/ml clinical transport medium. […] In addition, the FET sensor successfully detected SARS-CoV-2 in culture medium (limit of detection [LOD]: 1.6 x 101 pfu/ml) and clinical samples (LOD: 2.42 x 102 copies/ml). | 2020-04-15 |
| 32293224 | The current COVID-19 crisis continues to grow and has resulted in marked changes to clinical operations. […] In parallel with clinical preparedness, universities have shut down the majority of scientific research activities. | 2020-04-15 |
| 32293709 | With this letter, we proposed a hypothesis that could explain the interaction between HIV infection and the clinical course of SARS-CoV-2 infection. | 2020-04-15 |
| 32293713 | A handful of literatures have summarized its clinical and radiologic features, whereas therapies for COVID-19 are rather limited. […] The efficacy of this intervention was determined by the alleviation of symptoms, changes in radiologic abnormalities and laboratory tests. | 2020-04-15 |
| 32293714 | In clinical practice, not only fever and respiratory tract symptoms but also multiple organ symptoms are observed in patients diagnosed with COVID-19. […] Herein, we report a rare case of a patient diagnosed with COVID-19 who manifested with concomitant neurological symptoms. […] The patient developed fever and respiratory symptoms at disease onset, followed by muscle soreness, and subsequently altered consciousness and psychiatric symptoms, with positive signs based on neurological examination. […] This rare case indicates that SARS-CoV-2 can invade the central nervous system, thus causing neurological symptoms and signs. | 2020-04-15 |
| 32293716 | We aim to systematically review the clinical characteristics of Coronavirus disease 2019 (COVID-19). […] Seven datebases were searched to collect studies about the clinical characteristics of COVID-19 from 1 January 2020 to 28 February 2020. […] Fever (80.4%), fatigue (46%), cough (63.1%) and expectoration (41.8%) were the most common clinical manifestations. […] Other common symptoms included muscle soreness (33%), anorexia (38.8%), chest tightness (35.7%), shortness of breath (35%), dyspnea (33.9%). […] Minor symptoms included nausea and vomiting (10.2%), diarrhea (12.9%), headache (15.4%), pharyngalgia(13.1%), shivering (10.9%) and abdominal pain (4.4%). […] The most commonly experienced symptoms of COVID-19 patients were fever, fatigue, cough and expectoration. | 2020-04-15 |
| 32293741 | This retrospective study aimed to analysis the clinical characteristics and complications in death cases with novel coronavirus disease-19 (COVID-19). […] We collected the medical records of 92 patients with COVID-19 in Renmin Hospital of Wuhan University who died during January 6th to February 25th, 2020, summarized the clinical characteristics of complications. | 2020-04-15 |
| 32293807 | We systematically reviewed the clinical outcomes of using antiretroviral drugs for the prevention and treatment of coronaviruses and planned clinical trials. […] Three databases were screened from inception to 30 March 2020 for studies reporting clinical outcomes of patients with SARS, MERS or COVID-19 treated with antiretrovirals. […] From an initial screen of 433 titles, two randomized trials and 24 observational studies provided clinical outcome data on the use of antiretroviral drugs; most studies reported outcomes using LPV/r as treatment. […] In one randomized trial 99 patients with severe COVID-19 illness were randomized to receive LPV/r (400/100 mg twice a day) and 100 patients to standard of care for 14 days: LPV/r was not associated with a statistically significant difference in time to clinical improvement, although LPV/r given within 12 days of symptoms was associated with shorter time to clinical improvement; 28 day mortality was numerically lower in the LPV/r group (14/99) compared to the control group (25/100), but this difference was not statistically significant. […] On the basis of the available evidence it is uncertain whether LPV/r and other antiretrovirals improve clinical outcomes or prevent infection among patients at high risk of acquiring COVID-19. | 2020-04-16 |
| 32293817 | In this paper we share the early experiences from the clinical field in Northern Italy, where the epidemic started in February. | 2020-04-15 |
| 32293832 | Seven coronavirus species are known to cause human infection, four of which, HCoV 229E, HCoV NL63, HCoV HKU1 and HCoV OC43, typically cause cold symptoms in immunocompetent individuals. | 2020-04-15 |
| 32293834 | There have been more than 300 clinical trials going on, various antiviral and immunomodulating agents are in various stages of evaluation for COVID-19 in those trials and some of them will be published in the next couple of months. | 2020-04-15 |
| 32293910 | Patients have diverse clinical outcomes, but those with pre-existing cardiovascular (CV) disease, hypertension, and related conditions incur disproportionately worse outcome. […] The tissue localization of the receptors correlates with COVDI-19 presenting symptoms and organ dysfunction. | 2020-04-15 |
| 32294051 | We developed a triplex, real-time reverse transcription PCR for SARS-CoV-2 that maintained clinical performance compared with singleplex assays. | 2020-04-15 |
| 32294179 | Here we review the basic and clinical science spanning the intersections of diabetes, coronavirus infections, ACE2, and DPP4 biology, highlighting clinical relevance and evolving areas of uncertainty underlying the pathophysiology and treatment of T2D in the context of coronavirus infection. | 2020-04-15 |
| 32294264 | In a recent review on clinical characteristics of coronavirus disease 2019 in China, rash was observed in 0,2% of cases2 . | 2020-04-15 |
| 32294270 | Current researches emphasize on understanding of transmission patterns, severity, clinical features, and risk factors for infection, but the data remain limited. | 2020-04-15 |
| 32294271 | Recalcati noted that 20.4 % of the patients have cutaneous problem and mentioned that this is the first report on this clinical aspect of COVID-19. | 2020-04-15 |
| 32294273 | Many clinical manifestations of this virus are described and new symptoms are emerging particularly outside respiratory sphere, such as anosmia and ageusia which are recent ORL published symptoms. | 2020-04-15 |
| 32294285 | The authors found that abnormalities of liver function tests are common in COVID-19 patients, but the clinically significant liver dysfunction in COVID-19 was not a prominent feature of this illness and also may not have serious clinical consequences. | 2020-04-15 |
| 32294297 | Due to this pandemic, the rapid integration of virtual psychosocial care in bariatric surgery programs to address patients’ needs will create new opportunities for clinical and implementation science research. | 2020-04-15 |
| 32294485 | Data on the clinical characteristics and outcomes of patients with severe COVID-19 are limited. | 2020-04-15 |
| 32294503 | This study aims to observe the clinical features and outcomes of pregnant women who have been confirmed with COVID-19. […] These cases were subjected to pulmonary CT scan and routine blood test, manifested symptoms of fever, cough, chest tightness or gastrointestinal symptoms. […] They were admitted to an isolated suite, with clinical features and newborn babies being carefully observed. […] The clinical symptoms and laboratory indicators are not obvious for asymptomatic and mild COVID-19 pregnant women. | 2020-04-15 |
| 32294504 | Aimed to characterize the CT imaging and clinical course of asymptomatic cases with COVID-19 pneumonia. […] The characteristics of CT imaging and clinical feature were collected and analyzed. 58 asymptomatic cases with COVID-19 pneumonia admitted to our hospital between Jan 1, 2020 and Feb 23, 2020 were enrolled. […] On admission, patients had no symptoms and laboratory findings were normal. […] After short-term follow-up, 16 patients (27.6%) presented symptoms with lower lymphocyte count and higher CRP, mainly including fever, cough and fatigue. | 2020-04-15 |
| 32294617 | Undoubtedly, healthcare providers have had to rapidly alter care delivery models while simultaneously acknowledging the crucial unknowns of how these changes may affect clinical outcomes. | 2020-04-15 |
| 32294667 | The rapid increase in clinical cases of the new coronavirus disease, COVID-19, suggests high transmissibility. | 2020-04-15 |
| 32294713 | The sample consisted of 715 Brazilian adults aged 18-78 years, who answered the Big Five Inventory 2 Short (BFI-2-S) and factors from the Dimensional Clinical Personality Inventory 2 (IDCP-2). | 2020-04-15 |
| 32294796 | This study was conducted to explore the clinical value of noninvasive assessment of bedside ultrasound in the diagnosis of lung lesions of Coronavirus Disease-19. […] The clinical value of ultrasound in the noninvasive assessment of lung lesions was evaluated. […] Bedside ultrasound has important clinical significance for noninvasive assessment and dynamic observation of lung lesions in patients with Coronavirus Disease-19, which is worth further consideration. | 2020-04-15 |
| 32294807 | At present, there are no studies demonstrating the clinical efficacy of hydroxychloroquine for the prophylaxis or treatment of COVID-19 infection. | 2020-04-15 |
| 32294810 | The global 2019 coronavirus disease (COVID-19) pandemic has led to major challenges in clinical decision making when the demand for intensive care exceeds local capacity. | 2020-04-16 |
| 32294814 | COVID-19 is a highly infectious respiratory infection disease, which leads to dysfunction of respiratory, physical, and psychological of the patients. pulmonary rehabilitation is an important intervention for clinical patients as well as cure patients. […] With the deeper cognition of COVID-19 and accumulation of clinical experience, we proposed the recommendations for pulmonary rehabilitation of COVID-19 in adults based on the opinions of front-line clinical experts involved in the management of this epidemic and a review of the relevant literature and evidences: (1)for the inpatients with COVID-19, pulmonary rehabilitation would relieve the symptoms of dyspnea, anxiety, and depression; eventually improve physical function and the quality of life; (2)For severe/critical inpatients, the early performance of pulmonary rehabilitation is not suggested. […] These recommendations can serve as a clinical practice guidence and basis for pulmonary rehabilitation of COVID-19. | 2020-04-17 |
| 32294816 | The case reports 2 cases of novel coronavirus pneumonia diagnosed by concurrent bronchoalveolar lavage in our hospital, 1 case had a history of epidemiology, clinical symptoms and high imaging suspicion, but repeated negative throat swabs. […] Before the patient was discharged, the clinical symptoms disappeared, the chest CT showed significant improvement, and the pharynx swab was twice negative, reaching the discharge standard.We detected the ORF 1ab gene, the N gene and the nucleic acid of the new coronavirus in the broncho-alveolar lavage fluid of 2 patients. | 2020-04-17 |
| 32294817 | The experience and knowledge we gained from severe acute respiratory syndrome (SARS), especially with regard to the time course of viral replication, host immune response and clinical progression of the patient, may provide important insights into understanding and management of COVID-19. […] Clinical deterioration accompanied by decreasing viral load in the second week after symptom onset was noted both in SARS and COVID-19, suggesting that the lung damage at this phase is more related to excessive host immune response rather than uncontrolled viral replication. | 2020-04-17 |
| 32294858 | There were 3 cases of mild type, 27 cases of common type and 3 cases of severe type.There were 2 cases with hypertension, 1 case with postoperative lung,1 case with diabetes, 1 case with chronic bronchitis, and 1 case with bronchiectasis.SPSS25.0 Chi-square test was used to analyze the distribution of lesions in each lung lobe; SPSS25.0 Spearman correlation coefficient was used to analyze the image score and clinical classification. Results: There were 3 cases (9.1%) with normal lung and 30 cases (90.9%) with Novel Coronavirus Pneumonia(COVID-19) of the 2019-nCoV infected patients. […] The correlation coefficient between the degree of lesion distribution and clinical classification was 0.819, and the two were highly correlated.There were 30 cases (90.9%) with subpleural lesions, 17 cases (51.5%) with central lesions. | 2020-04-17 |
| 32295153 | Plant-based vaccines are a technology with proven viability, which have led to promising results for candidates evaluated at the clinical level, meaning this technology could contribute towards the fight against COVID-19. | 2020-04-16 |
| 32295188 | In particular, we focus on public health impact, pathophysiology and clinical manifestations, diagnosis, case management, emergency response and preparedness. | 2020-04-21 |
| 32295300 | To date, protease inhibitor drugs, especially HIV-1 protease inhibitors, have been available for human clinical use in the treatment of coronaviruses. | 2020-04-17 |
| 32295322 | Objective: To analyze the epidemiological characteristics and clinical features of the patients with 2019-nCoV infection in Nanyang City, so as to provide evidence for clinical diagnosis and treatment. Methods: The epidemiology, clinical symptoms, atory and radiologic data of 150 patients with 2019-nCoV infection admitted to the designated hospitals in Nanyang City from January 24,2020 to February 16, 2020 were retrospectively analyzed. Results: The 150 patients with 2019 nCov infection consisted of 67 men and 83 women, and the median age was 45±16 years; 69 of them were the first generation case,60 of them were the second generation case, 6 of them were the third generation case,the median incubation period of the first generation case was 5.4±2.2 days, and the second generation case was 6.7±3.1 days, and the first-generation cases are the majority in severe patients (69%) . […] The most common basic disease was hypertension (13 cases, 9%), diabetes (9 cases, 6%), and the most common symptom is fever(142 cases, 95%, 63% showed moderate fever) , cough and sputum(108 cases,72%), fatigue(23 cases,15%), anorexia(20 cases, 13%), headache, diarrhea, muscle soreness, sore throat as the first symptoms. […] The average time from onset of symptoms to consultation was 4.2±2.2 days for all patients. […] After active treatment, 45% of patients were discharged according to discharge standards. 33% of sever and critically ill patients were discharged, 49% of them were degraded hospitalization.The average length of hospitalization was 12±4 days. Conclusion: A history of epidemiological exposure, fever, chest CT with signs of pneumonia, normal or decreased WBC, and lymphocytopenia, eosinophilia are the clinical basis for the diagnosis of this disease, and most of the sever patients were the first generation cases. | 2020-04-16 |
| 32295324 | Eighty-one patients diagnosed as coronavirus disease-19 in Guangxi Zhuang Autonomous Region People’s Hospital were enrolled with ophthalmological consultation screening for novel coronavirus related conjunctivitis, including the inquiring of eye symptoms and checking for conjunctivitis-related signs. […] Conjunctival swab novel coronavirus nucleic acid test was performed on patients with clinical manifestation of conjunctivitis. Results: Only 3 of the 81 patients (3.70%) complained of eye discomfort, which appeared on the day 16.67±9.29 after the diagnosis of coronavirus disease-19. […] Screening of clinical symptoms and signs of conjunctivitis in the remaining 78 patients showed no significant abnormalities. Conclusions: There wasn’t any novel coronavirus related conjunctivitis in 81 patients with coronavirus disease-19.(Chin J Ophthalmol, 2020, 56:). 目的： 探讨新型冠状病毒肺炎（COVID-19）患者新型冠状病毒相关性结膜炎的患病情况。 | 2020-04-16 |
| 32295460 | Three main aspects are discussed, namely clinical, administrative, and training and educational. | 2020-04-16 |
| 32295661 | In particular, the majority of patients that are currently tested in Italy have severe clinical symptoms that usually require hospitalization and this translates to a large CFR. | 2020-04-30 |
| 32295662 | Finally, 28 had evidence-based clinical processes and operations. | 2020-05-07 |
| 32295811 | Every month, DTB scans sources of information on treatments, disease management and other healthcare topics for key items to bring to our readers’ attention and help them keep up to date. | 2020-05-28 |
| 32296046 | Of respondents who worked at an inpatient facility, 53.3% reported that only individuals with symptoms were being screened and 29.9% said that no screening was occurring. | 2020-04-20 |
| 32296473 | The initial clinical presentation of CoronaVirus Disease 2019 may be appendicular syndrome. | 2020-05-07 |
| 32296808 | We discuss important ethical considerations and predictive scoring systems that may assist clinical decision-making to optimise resource allocation. | 2020-05-18 |
| 32296817 | Investigators are employing unprecedented innovation in the design of clinical trials to rapidly and rigorously assess potentially promising therapies for COVID-19; this is in stark contrast to the continued near universal regressive practice of exclusion of pregnant and breastfeeding women from these trials. | 2020-04-30 |
| 32296824 | Decision curve and clinical impact curve analysis indicated that nomogram conferred high clinical net benefit. | 2020-04-30 |
| 32296884 | Here, we summarize our American College of Nuclear Medicine members’ experiences from Wuhan, China; Singapore; and the USA, so to provide advice to the nuclear medicine personnel for their clinical practice and management strategies in responding to COVID-19. | 2020-05-28 |
| 32296888 | Furthermore strictly defined hygiene measures to protect employees in various clinical scenarios should be set up. | 2020-04-20 |
| 32296910 | We propose several mechanisms by which coronavirus disease 2019 causes thrombocytopenia to better understand this disease and provide more clinical treatment options. | 2020-05-22 |
| 32296940 | Currently, the 2019 novel coronavirus (SARS-CoV-2) can be identified by virus isolation or viral nucleic acid detection; however, false negatives associated with the nucleic acid detection provide a clinical challenge and thus make the imaging examination crucial. […] Imaging exams have been a main clinical diagnostic criteria for the 2019 novel coronavirus disease (COVID-19) in China. […] • Imaging examination has become the indispensable means not only in the early detection and diagnosis but also in monitoring the clinical course, evaluating the disease severity, and may be presented as an important warning signal preceding the negative RT-PCR test results. | 2020-04-30 |
| 32297540 | The clinical and laboratory data of 383 patients with the definite outcome by March 1, 2020 in the Central Hospital of Wuhan were reviewed. | 2020-05-22 |
| 32297727 | The Brescia-COVID respiratory severity scale/algorithm is a stepwise management approach to COVID-19 patients based on clinical severity. […] The scale simplifies the clinical summary of a patient’s status, and allows clinicians to compare patients to one another and to track the trend of a patient’s level of respiratory severity over time. | 2020-04-20 |
| 32297828 | The correlation between the relative load of nasopharyngeal SARS-CoV-2 RNA and severe disease symptoms was analyzed. | 2020-04-16 |
| 32297980 | Based on our data, disease management in the 2 weeks following the first reported cases is of utmost importance. | 2020-04-28 |
| 32297981 | At present, it mainly relies on Real-time RT-PCR to detect SARS-CoV-2 virus nucleic acid collected from the clinical specimens of patients as the standard for diagnosis, discontinuation of quarantine and discharge.1,2 This article is protected by copyright. | 2020-04-27 |
| 32297985 | Information including age, gender and duration from illness onset to admission, clinical manifestations and laboratory data at admission, and length of hospital stay were evaluated. […] The clinical symptoms and laboratory tests at discharge were also assessed. […] At admission, no significant differences were found among the groups, including duration from illness onset to admission, clinical symptoms and main laboratory results. […] At discharge, 7/184 (4%) patients had a mild cough while their other symptoms had disappeared, and the proportion of patients with abnormal liver function and with increased leucocytes, neutrophils or erythrocyte sedimentation rate among the 184 patients were close to those at admission. […] In addition, the results of chest CT imaging, clinical manifestations, and laboratory tests at discharge were not completely consistent. | 2020-04-16 |
| 32297988 | Following the demonstration of the efficacy of hydroxychloroquine against severe acute respiratory syndrome coronavirus 2 in vitro, many trials started to evaluate its efficacy in clinical settings. […] We conducted a systematic review and meta-analysis with the objectives of evaluation of safety and efficacy of HCQ alone or in combination in terms of “time to clinical cure,” “virological cure,” “death or clinical worsening of disease,” “radiological progression,” and safety. […] In terms of clinical cure, two studies reported possible benefit in “time to body temperature normalization” and one study reported less “cough days” in the HCQ arm. […] No difference was observed in virological cure (OR, 2.37, 95% CI, 0.13-44.53), death or clinical worsening of disease (OR, 1.37, 95% CI, 1.37-21.97), and safety (OR, 2.19, 95% CI, 0.59-8.18), when compared with the control/conventional treatment. | 2020-05-03 |
| 32297995 | In this study, a meta-analysis was performed to investigate whether the IL-6/IFN-γ ratio can help predict clinical severity in patients with COVID-19. | 2020-04-28 |
| 32298029 | In this context, in Italy, we reorganized the National Health System and prioritized the clinical cancer care scenario, balancing risk of SARS-CoV-2 transmission versus the magnitude of clinical benefit deriving from a specific therapeutic approach. | 2020-04-27 |
| 32298036 | Finally, we discuss our preoperative clinical pathway for transmission mitigation including defining low-risk and high-risk surgery for transmission and role of preoperative COVID-19 testing. | 2020-05-29 |
| 32298146 | Multiple areas of surge planning progressed, simultaneously focused on infection control, clinical operational challenges, ICU surge capacity, staffing, ethics, and maintenance of staff wellness. […] The protocols developed focused on clinical decisions regarding intubation, the use of high-flow oxygen, engagement with infectious disease consultants, and cardiac arrest. […] Support was provided for both clinical and nonclinical staff affected by the profound impact COVID-19 had on our city. | 2020-05-29 |
| 32298247 | Although 4,336 (92%) HCP patients reported having at least one symptom among fever, cough, or shortness of breath, the remaining 8% did not report any of these symptoms. | 2020-04-17 |
| 32298249 | Among 121 hospital A health care personnel (HCP) who were exposed to the patient, 43 (35.5%) developed symptoms during the 14 days after exposure and were tested for SARS-CoV-2; three had positive test results and were among the first known cases of probable occupational transmission of SARS-CoV-2 to HCP in the United States. | 2020-04-17 |
| 32298251 | This report presents age-stratified COVID-19-associated hospitalization rates for patients admitted during March 1-28, 2020, and clinical data on patients admitted during March 1-30, 2020, the first month of U.S. surveillance. […] In addition, older adults and persons with serious underlying medical conditions should avoid contact with persons who are ill and immediately contact their health care provider(s) if they have symptoms consistent with COVID-19 (https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html) (5). […] Ongoing monitoring of hospitalization rates, clinical characteristics, and outcomes of hospitalized patients will be important to better understand the evolving epidemiology of COVID-19 in the United States and the clinical spectrum of disease, and to help guide planning and prioritization of health care system resources. | 2020-04-16 |
| 32298273 | And thus, both the vertical transmission and the placenta dysfunction/abortion caused by SARS-CoV-2 need to be further carefully investigated in clinical practice. | 2020-04-22 |
| 32298473 | Our aim is to provide a template for the development of clinical recommendations and policies to mitigate the impact of the COVID-19 pandemic on liver patients and healthcare providers. | 2020-04-16 |
| 32298480 | FDA/EMA-approved monitoring guidelines, clinical practice guidelines, and relevant, up-to-date publications regarding initiation and monitoring of beta-blocker therapy were used to inform the recommendations. […] Clinical decision-making guidelines about when telehealth is an appropriate alternative to in-office visits, including medication initiation, dosage changes, and ongoing evaluation, are included. | 2020-05-16 |
| 32298643 | In this article, the authors share several operational guidelines and strategies implemented in our practice to reduce spread of COVID-19 and maintain clinical and educational needs of a teaching hospital. | 2020-04-29 |
| 32298676 | This study analyzed salivary samples of COVID-19 patients and compared the results with their clinical and laboratory data. […] Prevalence of positivity in saliva and association between clinical data and the cycle threshold as a semiquantitative indicator of viral load were considered. […] The role of saliva in COVID-19 diagnosis could not be limited to a qualitative detection of the virus, but it may also provide information about the clinical evolution of the disease. | 2020-05-05 |
| 32298686 | All the outpatient clinical activities during the 4 weeks following the national lockdown (March 9-April 3, 2020) in the Department of Urology of the Trento Province, Italy, were reviewed and categorized. […] Seventy-four percent of face-to-face visits regarded suspected recurrent or new onset malignancy or potentially dangerous clinical conditions (severe urinary symptoms or complicated urinary stones or infection). | 2020-05-29 |
| 32298745 | The patient avoided mechanical ventilation and acquired an immediate clinical and radiological improvement, after treatment of intensive plasma exchange (PE) followed by intravenous immunogloblin (IVIG). […] What’s more, it may improve poor clinical outcomes of these patients. | 2020-05-05 |
| 32298767 | We evaluated the clinical characteristics of COVID-19 in patients with abnormal liver test results. […] Clinical records and laboratory results were obtained from 417 patients with laboratory-confirmed COVID-19 who were admitted to the only referral hospital in Shenzhen, China from January 11 to February 21, 2020 and followed up to March 7, 2020. […] Information on clinical features of patients with abnormal liver tests were collected for analysis. | 2020-05-05 |
| 32298769 | This includes an intensification of the preventative care provided to patients with compensated cirrhosis, proactive chronic disease management, robust telehealth programs, and a reorganization of care delivery to provide a full service of care with flexible clinical staffing. | 2020-05-05 |
| 32298802 | This longitudinal study surveyed the general population twice - during the initial outbreak, and the epidemic’s peak four weeks later, surveying demographics, symptoms, knowledge, concerns, and precautionary measures against COVID-19. […] IES-R measures PTSD symptoms in survivorship after an event. […] Nevertheless, the mean IES-R score of the first- and second-survey respondents were above the cut-off scores (>24) for PTSD symptoms, suggesting that the reduction in scores was not clinically significant. | 2020-04-19 |
| 32298803 | Past pandemics have demonstrated that diverse types of neuropsychiatric symptoms, such as encephalopathy, mood changes, psychosis, neuromuscular dysfunction, or demyelinating processes, may accompany acute viral infection, or may follow infection by weeks, months, or longer in recovered patients. | 2020-04-24 |
| 32298988 | There is a need to study the clinical features of patients in a hospital near Wuhan. […] To identify clinical features of patients with COVID-19 in a tertiary hospital near Wuhan. […] General information, clinical manifestations, laboratory data, and computed tomography (CT) data were collected for 225 patients diagnosed of COVID-19 admitted between January 20 and February 14, 2020, to the Hanchuan City People’s Hospital. […] The major clinical symptoms were fever (84.44% of patients), cough (56.44% of patients), and dyspnea (4.00% of patients); 3.56%-22.67% of subjects suffered from expectoration, fatigue, chills, headache, chest pain, and pharyngalgia. […] Clinical characteristics of COVID-19 patients in the tertiary hospital near Wuhan are very similar to those found in Wuhan, but the lower mortality. | 2020-05-27 |
| 32299017 | Precise and targeted documentation of neurological symptoms, detailed clinical, neurological, and electrophysiological investigations of the patients, attempts to isolate SARS-CoV-2 from cerebrospinal fluid, and autopsies of the COVID-19 victims may clarify the role played by this virus in causing neurological manifestations. | 2020-05-27 |
| 32299200 | The symptoms are undiagnostic, the results of viral nucleic acid detection method (PCR) can delay, so that chest computerized tomography is often key diagnostic test in patients with possible COVID-19 pneumonia. | 2020-04-22 |
| 32299205 | Therefore, how to ensure the triage of the patient with acute respiratory symptoms should be determined in advance, the contact distance should be arranged to be at least 2 m, COVID-19 suspect or diagnosed patient should be instructed to wear a surgical mask. | 2020-04-22 |
| 32299206 | Last human coronavirus which emerged world from Wuhan China, SARS CoV-2 and its clinical expression, Coronavirus disease (COVID-19) recently taken a significant place in our daily practice. | 2020-04-22 |
| 32299304 | These results support the CAS as an efficient and valid tool for clinical research and practice. | 2020-05-08 |
| 32299636 | Neurological symptoms were rarely reported in the SARS-CoV and MERS-CoV epidemics, although isolated cases were described. […] There are also reports of cases of neurological symptoms associated with CoV-OC43 and CoV-229E infection. […] Although neurological symptoms are not frequent in coronavirus epidemics, the high number of patients with SARS-CoV-2 infection may explain the presence of the virus in the CNS and increase the likelihood of early- or delayed-onset neurological symptoms. | 2020-05-04 |
| 32299752 | At present, Canada has more than 8000 cases of COVID-19, with considerable variation in rates of infection among provinces and territories.3 Amid concerns over growing resource constraints, cardiac surgeons from across Canada have been forced to make drastic changes to their clinical practices. | 2020-05-10 |
| 32300245 | We validated our method using contrived reference samples and clinical samples from patients in the United States, including 36 patients with COVID-19 infection and 42 patients with other viral respiratory infections. | 2020-04-17 |
| 32300370 | While many younger people experience no or mild symptoms on infection, older adults are highly susceptible to life-threatening respiratory and systemic conditions which demand a full understanding and leveraging of knowledge of the differences between immunity in young and old people. | 2020-04-20 |
| 32300496 | In December 2019, several patients from Wuhan, China were admitted to hospitals with symptoms of pneumonia. […] As the number of patients presenting with similar symptoms started to rise, the causative agent was eventually isolated from samples. | 2020-04-20 |
| 32300516 | While there are currently no specific data for psoriasis biologics and COVID-19, data are presented here from phase III clinical trials of psoriasis biologics on rates of upper respiratory infection, influenza, and serious infection. | 2020-05-16 |
| 32300673 | The finding heavily supports an intense requirement for additional prompt, inclusive investigations that combine genomic detail, epidemiological information and graph records of the clinical features of patients with COVID-19. | 2020-04-21 |
| 32300971 | We aim to identify differences in CT imaging and clinical manifestations between pneumonia patients with and without COVID-19, and to develop and validate a diagnostic model for COVID-19 based on radiological semantic and clinical features alone. […] Three models were constructed using radiological semantic and clinical features through multivariate logistic regression. […] Clinical usage was evaluated by decision curve analysis and nomogram. […] Eighteen radiological semantic features and seventeen clinical features were identified to be significantly different. […] The clinical and radiological semantic models provided a better diagnostic performance and more considerable net benefits. […] Based on CT imaging and clinical manifestations alone, the pneumonia patients with and without COVID-19 can be distinguished. […] A model composed of radiological semantic and clinical features has an excellent performance for the diagnosis of COVID-19. […] • Based on CT imaging and clinical manifestations alone, the pneumonia patients with and without COVID-19 can be distinguished. […] • A diagnostic model for COVID-19 was developed and validated using radiological semantic and clinical features, which had an area under the curve value of 0.986 (95% CI 0.966~1.000) and 0.936 (95% CI 0.866~1.000) in the primary and validation cohorts, respectively. | 2020-04-30 |
| 32301099 | We reported on the epidemiological, clinical, laboratory, and radiological characteristics of children cases to help health workers better understand and provide timely diagnosis and treatment. […] Epidemiological, clinical, laboratory, and radiological characteristics of children and adults were analyzed and compared. […] Most cases in children were mild (21.4%) and conventional cases (78.6%), with mild clinical signs and symptoms, and all cases were of family clusters. […] Fever (35.7%) and dry cough (21.4%) were described as clinical manifestations in children cases. […] Dry cough and phlegm were not the most common symptoms in children compared with adults (p = 0.03). […] The clinical symptoms of children are mild, there is substantial lung injury even among children, but that there is less clinical disease, perhaps because of a less pronounced inflammatory response, and that the occurrence of this pattern appears to inversely correlate with age. | 2020-05-29 |
| 32301155 | The clinical characteristics, management, and outcome of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after solid organ transplant (SOT) remain unknown. […] After a median follow-up of 18 days from symptom onset, 30.8% (4/13) of survivors developed progressive respiratory failure, 7.7% (1/13) showed stable clinical condition or improvement, and 61.5% (8/13) had been discharged home. | 2020-05-10 |
| 32301198 | Here, we report the clinical features and our treatment approach for a kidney transplant patient with a diagnosis of COVID-19. | 2020-05-22 |
| 32301206 | With clinical placement and exams cancelled, we are determined to use our hard-earned skills in some way, to help in what is the biggest global emergency of our lifetime. | 2020-05-07 |
| 32301284 | The symptoms presently recognized by the World Health Organization are cough, fever, tiredness, and difficulty breathing. | 2020-04-17 |
| 32301300 | A walk-through (WT) screening center using negative pressure booths that is inspired by the biosafety cabinet has been designed and implemented in Korea for easy screening of COVID-19 and for safe and efficient consultation for patients with fever or respiratory symptoms. | 2020-04-20 |
| 32301390 | Examination of the original clinical specimen from which the isolate was derived, and 26 additional SARS-CoV-2 positive clinical specimens, failed to detect these variants. | 2020-05-06 |
| 32301508 | Several systematic reviews (SRs) have been conducted on the COVID-19 outbreak, which together with the SRs on previous coronavirus outbreaks, form important sources of evidence for clinical decision and policy making. | 2020-04-28 |
| 32301600 | While in most cases, mild symptoms are observed, in some cases the infection leads to serious pulmonary disease. […] Reported data suggest that symptoms in pregnant women are similar to those in other people, and that there is no evidence for higher maternal or fetal risks. | 2020-04-28 |
| 32301631 | OBJECTIVE. This series of patients presented to the emergency department (ED) with abdominal pain, without the respiratory symptoms typical of coronavirus disease (COVID-19), and the abdominal radiologist was the first to suggest COVID-19 infection because of findings in the lung bases on CT of the abdomen. CONCLUSION. COVID-19 infection can present primarily with abdominal symptoms, and the abdominal radiologist must suggest the diagnosis when evaluating the lung bases for typical findings. | 2020-04-17 |
| 32301647 | Patients with negative reverse-transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2 in nasal-pharyngeal swabs, negative chest CT, and incomplete clinical data were excluded. […] Clinical parameters included demographics, comorbidities, symptoms and symptom duration, oxygen saturation and laboratory values. […] Logistic regression was used to evaluate relationship between clinical parameters and CT metrics versus patient outcome (ICU admission/death vs. no ICU admission/ death). […] In comparison with clinical model containing only clinical parameters (AUC, 0.83), all three quantitative models showed higher diagnostic performance (AUC 0.86 for all models). […] The models containing %V-WAL<73% and VOL-WAL<2.9L were superior in terms of performance as compared to the models containing only clinical parameters (P=0.04 for both models). | 2020-04-27 |
| 32301692 | While it affects the respiratory system causing symptoms ranging from fever, cough, dyspnea, diarrhea, nausea, myalgia and fatigue, it eventually causes pneumonia and respiratory distress needing oxygenation and ventilation. | 2020-05-20 |
| 32301746 | In addition, the need of certified laboratories, expensive equipment and trained personnel led many countries to limit the rRT-PCR tests only to individuals with pronounced respiratory syndrome symptoms. […] Methods We analyzed the plasma levels of white blood cells (WBCs), platelets, C-reactive protein (CRP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (GGT), alkaline phosphatase and lactate dehydrogenase (LDH) of 207 patients who, after being admitted to the emergency room of the San Raffaele Hospital (Milan, Italy) with COVID-19 symptoms, were rRT-PCR tested. | 2020-04-17 |
| 32301749 | The clinical spectrum of the disease varies from mild to severe acute respiratory distress syndrome (ARDS). […] Methods The imprecision of the MAGLUMI™ 2000 Plus 2019-nCov IgM and IgG assays (Snibe, Shenzhen, China) was assessed by adopting the Clinical and Laboratory Standards Institute (CLSI) EP15-A3 protocol. | 2020-04-17 |
| 32301761 | Coronavirus disease 2019 (COVID-19) most commonly presents with respiratory symptoms, including cough, shortness of breath, and sore throat. […] However, digestive symptoms also occur in patients with COVID-19 and are often described in outpatients with less severe disease. […] In this study, we sought to describe the clinical characteristics of COVID-19 patients with digestive symptoms and mild disease severity. […] We identified COVID-19 patients with mild disease and one or more digestive symptoms (diarrhea, nausea, and vomiting), with or without respiratory symptoms, and compared them with a group presenting solely with respiratory symptoms. […] We then compared the clinical features between those with digestive symptoms and those with respiratory symptoms. […] There were 206 patients with low severity COVID-19, including 48 presenting with a digestive symptom alone, 69 with both digestive and respiratory symptoms, and 89 with respiratory symptoms alone. […] Between the 2 groups with digestive symptoms, 67 presented with diarrhea, of whom 19.4% experienced diarrhea as the first symptom in their illness course. […] Patients with digestive symptoms presented for care later than those with respiratory symptoms (16.0 ± 7.7 vs 11.6 ± 5.1 days, P < 0.001). […] Nevertheless, patients with digestive symptoms had a longer duration between symptom onset and viral clearance (P < 0.001) and were more likely to be fecal virus positive (73.3% vs 14.3%, P = 0.033) than those with respiratory symptoms. […] We describe a unique subgroup of COVID-19 patients with mild disease severity marked by the presence of digestive symptoms. […] These patients are more likely to test positive for viral RNA in stool, to have a longer delay before viral clearance, and to experience delayed diagnosis compared with patients with only respiratory symptoms. | 2020-04-23 |
| 32301764 | This consensus statement provides information on the neurological manifestations of COVID-19, advice for neuroanesthesia clinical practice during emergent neurosurgery, interventional radiology (excluding endovascular treatment of acute ischemic stroke), transnasal neurosurgery, awake craniotomy and electroconvulsive therapy, as well as information about healthcare provider wellness. | 2020-05-22 |
| 32301766 | Pre-clinical models suggest that ACE2 upregulation confers protective effects in acute lung injury. […] We review current knowledge of the role of ACE2 in cardiovascular physiology and SARS-CoV-2 virology as well as clinical data to inform the management of patients with or at risk for COVID-19 who require renin-angiotensin-aldosterone system inhibitor therapy. | 2020-05-16 |
| 32301997 | The clinical and laboratory data were collected. […] Clinical characteristics analysis of 48 cases of COVID-19 showed that RNAaemia was diagnosed only in the critically ill group and seemed to reflect the severity of the disease. | 2020-04-30 |
| 32302000 | Most of studies paid attention to epidemiological, clinical, and radiological features of inpatients with COVID-191-3. […] However, little studies have focused on clinical characteristics of discharged patients with severe COVID-19, especially the duration of viral shedding. | 2020-04-30 |
| 32302069 | These assays can be used for research studies and for testing in clinical laboratories. | 2020-04-22 |
| 32302257 | The documented clinical experience, the measures of professional prevention, and the actual Italian situation were reported and described. | 2020-04-17 |
| 32302280 | The National Institutes of Health is conducting a Phase 1 clinical trial to evaluate for a potential vaccine and the recipients have started to receive the investigational vaccine.2 We present a brief overview of the potential prophylactic and treatment agents under investigation, some which could be initiated in the ED if proven effective. | 2020-05-21 |
| 32302286 | Which non-clinical volunteers can we use and in what capacities? | 2020-05-20 |
| 32302401 | If our hypothesis is correct, targeting NETs directly and/or indirectly with existing drugs may reduce the clinical severity of COVID-19. | 2020-04-23 |
| 32302411 | AZ is not approved for the treatment of viral infections, and there is no well-controlled, prospective, randomized clinical evidence to support AZ therapy in coronavirus disease 2019 (COVID-19). […] It is essential that the clinical pharmacology (CP) characteristics of AZ be considered in planning and conducting clinical trials of AZ alone or in combination with other agents, to ensure safe study conduct and to increase the probability of achieving definitive answers regarding efficacy of AZ in the treatment of COVID-19. […] The safety profile of AZ used as an antibacterial agent is well established.1 This work assesses published in vitro and clinical evidence for AZ as an agent with antiviral properties. […] It also provides basic CP information relevant for planning and initiating COVID-19 clinical studies with AZ, summarizes safety data from healthy volunteer studies, and safety and efficacy data from phase II and phase II/III studies in patients with uncomplicated malaria, including a phase II/III study in pediatric patients following administration of AZ and CQ in combination. | 2020-05-12 |
| 32302438 | Clinical trials are urgently needed to establish the type of drug, dosage and optimal duration of prophylaxis. | 2020-04-17 |
| 32302448 | Reports of thromboembolic complications are scarce but suggestive for a clinical relevance of the problem. […] The pro-coagulant pattern of these patients may justify the clinical reports of thromboembolic complications (pulmonary embolism) during the course of the disease. | 2020-05-06 |
| 32302462 | Patients that are critically ill with COVID-19 have hallmark signs of disseminated intravascular coagulation (DIC)(2), and as noted in the ISTH interim guidance and our own clinical practice, thrombosis is the overwhelming phenotype with rare bleeding complications. | 2020-04-17 |
| 32302706 | Moreover, accumulating evidence has demonstrated the implication of ACE2 in the pathological progression in tissue injury and several chronic diseases, ACE2 may also be essential in the progression and clinical outcomes of COVID-19. | 2020-05-30 |
| 32302722 | The most common symptoms at onset were fever (65, 81.25%), cough (47, 58.75%), fatigue (28, 35%), myalgia (19, 23.75%), expectoration (19, 23.75%), and diarrhea (15, 18.75%). […] Patients of frontline medical workers at a single-center hospital showed some unique clinical and laboratory findings compared with other patients in Wuhan and outside of Wuhan. | 2020-05-03 |
| 32302782 | To raise awareness for possible benefits of examining known COVID-19 patients presenting sudden clinical worsening with CT pulmonary angiography instead of standard non-contrast chest CT. | 2020-05-30 |
| 32302816 | This study aimed to investigate the psychological symptoms of ordinary Chinese citizens during the Level I Emergency Response throughout China. […] Based on a cut-off point of the GSI T-scores of 63, the overall sample was divided into high and low-risk groups. of the 1,060 participants investigated in China, more than 70% of them have moderate and higher level of psychological symptoms specifically elevated scores for obsessive compulsion, interpersonal sensitivity, phobic anxiety, and psychoticism. […] Those who were of over 50 years old, had an undergraduate education and below, were divorced or widowed, and agricultural workers had significantly more symptoms. | 2020-05-19 |
| 32302817 | It has been associated with anxiety including multiple clinical activities, depression in the face of the coexistence of countless deaths, long work shifts with the most diverse unknowns and demands in the treatment with patients with COVID-19. | 2020-05-19 |
| 32302927 | Furthermore, in cases of high clinical suspicion for COVID-19, a positive CXR may obviate the need for CT. | 2020-05-22 |
| 32302935 | Preliminary evidence suggests that symptoms of anxiety and depression (16-28%) and self-reported stress (8%) are common psychological reactions to the COVID-19 pandemic, and may be associated with disturbed sleep. | 2020-05-29 |
| 32302953 | We report the epidemiological, clinical, laboratory, and high-resolution CT findings for these children. […] Clinical manifestations included fever in four cases, respiratory symptoms in three cases, febrile convulsions in one case, vomiting in one case, abdominal pain in one case, and asymptomatic infection in two cases. | 2020-05-27 |
| 32302954 | The number of cases has increased rapidly, but information on the clinical characteristics remains limited. […] This paper describes the epidemiological and clinical characteristics of COVID-19. […] This study included a retrospective, single-center case series of 99 consecutively hospitalized patients with confirmed COVID-19 at Chengdu Public Health Clinical Medical Center in Chengdu, China, from January 16 to February 20, 2020. […] We collected and analyzed epidemiological, demographic, clinical, laboratory, radiological, and treatment data. […] Common symptoms included fever (85 [86 %]), dry cough (84 [85 %]), and fatigue (72 [73 %]). […] We analyzed the clinical characteristics of patients. | 2020-05-27 |
| 32302955 | Here, we report the clinical characteristics of the newborns delivered by SARS-CoV-2 infected pregnant women. […] We prospectively collected and analyzed the clinical features, laboratory data and outcomes of 7 newborns delivered by SARS-CoV-2 infected pregnant women in Zhongnan Hospital of Wuhan University during January 20 to January 29, 2020. 4 of the 7 newborns were late preterm with gestational age between 36 weeks and 37 weeks, and the other 3 were full-term infants. | 2020-05-27 |
| 32303090 | The clinical manifestations of COVID-19 can be subtle, encompassing a broad spectrum from asymptomatic mild disease to severe respiratory illness. | 2020-05-29 |
| 32303365 | Obviously clinical trials are necessaries, but due to the potential benefit of these two therapies we highly recommended to add to the therapeutic arsenal. | 2020-05-21 |
| 32303564 | Food & Drug Administration (FDA) for the detection of SARS-CoV-2, but little has been studied to determine how well these assays perform using clinical specimens. | 2020-04-18 |
| 32303590 | In SARS-CoV-2-infected macaques, virus was excreted from nose and throat in the absence of clinical signs and detected in type I and II pneumocytes in foci of diffuse alveolar damage and in ciliated epithelial cells of nasal, bronchial, and bronchiolar mucosae. | 2020-05-31 |
| 32303607 | In the UK, we have rapidly mobilised inflammatory bowel disease (IBD) centres in order that preparations can be made to protect our patients and the clinical services they rely on. […] Further considerations are given to service provision, medical and surgical therapy, endoscopy, imaging and clinical trials. | 2020-05-13 |
| 32303609 | Although covid-19 leads to little or mild flu-like symptoms in the majority of affected patients, the disease may cause severe, frequently lethal complications such as progressive pneumonia, acute respiratory distress syndrome and organ failure driven by hyperinflammation and a cytokine storm syndrome. | 2020-05-14 |
| 32303650 | Patient data were obtained from medical records from the University Hospital “Príncipe de Asturias”, Alcalá de Henares, Madrid, Spain and from the University Hospital “12 de Octubre”, Madrid, Spain. […] The full clinical spectrum of neurological symptoms in patients with COVID-19 remains to be characterized. | 2020-04-18 |
| 32303672 | One difference between this case and the known clinical course of COVID-19 is that did not develop cough. […] Another interesting feature of our case is that, despite tetraplegia, the clinical course was not severe. | 2020-04-24 |
| 32304092 | Data were collected from medical records by 11 neurologists using a standard case report form. […] Two people had seizurelike symptoms during hospitalization due to acute stress reaction and hypocalcemia, and 84 (27%) had brain insults or metabolic imbalances during the disease course known to increase the risk of seizures. | 2020-05-02 |
| 32304191 | The epidemiological and clinical patterns of COVID-19 and treatment approaches in pediatric patients still remain unclear although many pediatric reports are published. […] This review aims to summarize the current epidemics, clinical presentations, diagnosis, and treatment of COVID-19 in pediatric patients. | 2020-04-22 |
| 32304395 | His clinical course involved rapid and profound respiratory decompensation such that he required support with venovenous extracorporeal membrane oxygenation (VV-ECMO). | 2020-05-30 |
| 32304401 | These areas affecting inpatient paradigms include surgical priority, physical or social distancing, file sharing for online clinical communications, and physician wellness. | 2020-05-25 |
| 32304402 | To assess the clinical severity of COVID-19 pneumonia using qualitative and/or quantitative chest CT indicators and identify the CT characteristics of critical cases. | 2020-04-23 |
| 32304435 | Currently, there is no specific treatment or approved vaccine against COVID-19 and many clinical trials are currently investigating potential medications to treat COVID-19. […] This short review aims to focus on the impact of COVID-19 on a cancer patient and discuss management options and recommendation in addition to highlighting the currently available clinical guidelines and resources. | 2020-05-29 |
| 32304509 | Symptoms are usually less severe in children than in adults. […] Clinical physicians should be alert to asymptomatic children with COVID-19. | 2020-05-19 |
| 32304747 | Controlled clinical studies should be conducted to determine whether ARBs may be included as additional therapy for COVID-19 patients. | 2020-05-20 |
| 32304772 | The prognostic effects of variables, including clinical features and laboratory findings, were analyzed by using Kaplan-Meier methods and a Cox proportional hazards model. […] The proposed nomogram accurately predicted clinical outcomes of patients with COVID-19 based on individual characteristics. | 2020-05-28 |
| 32304822 | The children had no symptoms or mild flu-like illness. | 2020-05-20 |
| 32304994 | Fever (83.8%) and cough (70.9%) were the two most common symptoms. […] The binary logistic analysis identified elevated NLR (hazard risk [HR] 2.46, 95% confidence interval [CI] 1.98-4.57) and age (HR 2.52, 95% CI 1.65-4.83) as independent factors for poor clinical outcome of COVID-19. […] Elevated age and NLR can be considered independent biomarkers for indicating poor clinical outcomes. | 2020-05-28 |
| 32305025 | To investigate the epidemiological history and initial clinical characteristics of 10 patients with family aggregation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Western Chongqing, China. | 2020-05-27 |
| 32305134 | COVID-19 infected patients can be asymptomatic carriers or present with mild-to-severe respiratory symptoms. […] In our multicenter case series, we outline the clinical presentations and illustrate the most common imaging manifestations in patients hospitalized with COVID-19. | 2020-04-22 |
| 32305181 | In the current document, the European Society for Clinical Nutrition and Metabolism (ESPEN) aims at providing concise guidance for nutritional management of COVID-19 patients by proposing 10 practical recommendations. | 2020-05-31 |
| 32305249 | The typical clinical manifestations were fever, cough, dyspnea, and myalgia or fatigue. […] Less common symptoms included headache, diarrhea, nausea and vomiting. […] The case demonstrate that gastrointestinal symptoms ware not rare in NCIP, and diarrhea could be the initial symptom. | 2020-04-22 |
| 32305287 | Here we describe the case of a young woman presenting with severe pulmonary embolism, without any associated symptoms of infections. […] Despite emergency surgical embolectomy, her clinical conditions continued to deteriorate. | 2020-04-21 |
| 32305359 | The American Society for Transplantation and Cellular Therapy Pharmacy Special Interest Group Steering Committee aims to provide pharmacy practice management recommendations for how to transition clinical HCT or cellular therapy pharmacy services using telemedicine capabilities in the inpatient and outpatient settings to maintain an equivalent level of clinical practice while minimizing viral spread in a high-risk, immunocompromised population. […] In addition, the Steering Committee offers clinical management recommendations for COVID-19 in HCT and cellular therapy recipients based on the rapidly developing literature. […] As the therapeutic and supportive care interventions for COVID-19 expand, collaboration with clinical pharmacy providers is critical to ensure safe administration in HCT recipients. […] The COVID-19 pandemic has challenged all members of the healthcare team, and we must continue to remain vigilant in providing pharmacy clinical services to one of the most high-risk patient populations while also remaining committed to providing compassionate and safe care for patients undergoing HCT and cellular therapies. | 2020-05-29 |
| 32305506 | We hypothesize that factors related to ethnicity, environment, behaviors, associated illness, and medications involving this complex system are probably responsible for situations regarded as anomalous from both an epidemiological and a clinical point of view, but, taken together, such factors may explain most of the aspects of current outbreak. | 2020-05-17 |
| 32305587 | Based on our experience, further clinical studies are recommended for COVID-19 PEP. | 2020-04-29 |
| 32305589 | Some counties are against the use of these drugs because of adverse effects associated with drug repurposing and lack of statistically significant clinical data but they were found to be effective in some countries to treat affected COVID-19 patients (Off label/ Investigational). […] There is a need to reassess the in vitro data and to carry out randomised clinical trials. | 2020-04-24 |
| 32305883 | Preliminary reports on COVID-19 patients’ clinical and laboratory findings include thrombocytopenia, elevated D-dimer, prolonged prothrombin time, and disseminated intravascular coagulation. | 2020-05-27 |
| 32305884 | Studies are rapidly published to share information regarding epidemiology, clinical and diagnostic patterns, and prognosis. | 2020-05-28 |
| 32305937 | Moreover, the computer-aided platforms help radiologists make clinical decisions, i.e., for disease diagnosis, tracking, and prognosis. | 2020-05-01 |
| 32306036 | We found virus shedding was up to 6 weeks after onset of symptoms. | 2020-04-30 |
| 32306118 | Otorhinolaryngological manifestations are common symptoms of COVID-19. […] This study provides a brief and precise review of the current knowledge regarding COVID-19, including disease transmission, clinical characteristics, diagnosis, and potential treatment. […] Upper respiratory tract (URT) symptoms were commonly observed in younger patients and usually appeared initially. […] Ear, nose and throat (ENT) symptoms may precede the development of severe COVID-19. […] Additional studies analyzing why some patients develop ENT symptoms during COVID-19 and others do not are needed. | 2020-04-30 |
| 32306166 | With the cooperation of the whole hospital and radiology department, a number of effective evaluation methods have been carried out to ensure the optimization of clinical protection. […] To our knowledge, the establishment of standardized protection and clear process has opened up a new idea of epidemic prevention management, which can effectively provide timely, efficient, and accurate support for clinical research, and promote the transformation from clinical research type to scientific research management type. | 2020-05-29 |
| 32306288 | Since in vitro studies and a preliminary clinical report suggested the efficacy of chloroquine for COVID-19-associated pneumonia, there is increasing interest in this old antimalarial drug. […] Clinical experience has shown that chloroquine has a narrow safety margin, as three times the adult therapeutic dosage for malaria can be lethal when given as a single dose. | 2020-05-08 |
| 32306452 | We reasonably speculate several potential directions of clinical management including host-directed therapies aiming to restore dysregulated RAS caused by ACE2 deficiency. | 2020-05-06 |
| 32306491 | Although some insights have been garnered in the study of cardiovascular diseases for these patients, these insights remain fragmented and have yet to cement clear guidelines for actionable clinical practice. […] While some information is available, further studies are imperative for a more cohesive understanding of the cardiac pathophysiology in COVID-19 patients to promote more informed treatment and, ultimately, better clinical outcomes. | 2020-04-19 |
| 32306492 | Early and effective predictors of clinical outcomes is urgent needed to improve management of Covid-19 patients. | 2020-04-19 |
| 32306500 | Pre-clinical responses to fast-moving infectious disease outbreaks heavily depend on choosing the best isolates for animal models that inform diagnostics, vaccines and treatments. | 2020-05-25 |
| 32306513 | The patient had been already treated with topical and traditional therapies, without any clinical benefits. | 2020-04-29 |
| 32306596 | Based on our clinical practice, the four major measures of strengthening pre-hospital screening, perioperative prevention and control, medical staff protection, and ward management were adopted. […] Our preliminary practice shows that following the work guidelines issued by the Guangdong Province COVID-19 Prevention and Control Office and adopting precise management strategies in combination with the specific clinical features of gastrointestinal surgery, it is possible to safely resume regular care for the patients and comply to epidemic control at the same time. | 2020-04-20 |
| 32306597 | Methods: A retrospective cohort study was carried out to analyze the clinical data of selective endoscopy performed at the Endoscopic Center, Zhongshan Hospital of Fudan University from February 20 to March 6, 2020. […] Clinical data included epidemiological questionnaire, chief complaints, endoscopic findings and biopsy pathology results, etc. […] Meanwhile, the clinical data of selective endoscopy during the same period from February 20 to March 6, 2019 were collected as the control group to compare the overall results of endoscopy examinations during the epidemic and the detection rate of GI malignancy. […] Conclusion: Compared with the same period in 2019, the number of selective endoscopy decreases sharply during the epidemic period, while the detection rate of various GI malignant tumors increases significantly, which indicates that patients with high-risk symptoms of GI malignancies should still receive endoscopy as soon as possible. […] Provided strict adherence to the epidemic prevention standards formulated by the state and professional societies, it is necessary to carry out clinical diagnosis and treatment as soon as possible. | 2020-04-20 |
| 32306616 | Based on the previous studies and our own research, we summarize the potential transmission route and clinical symptoms of COVID-2019 in the eye, as well as the further prevention and research, with the expectation of contributing to the development in the field of infectious eye disease in China. | 2020-04-20 |
| 32306656 | In view of the above questions, this article now puts forwards the corresponding suggestions and considerations from the perspective of clinical infectious diseases physician. | 2020-04-21 |
| 32306657 | Objective: To investigate the clinical features and outcome of treatment for novel coronavirus pneumonia. Methods: Literature on novel coronavirus pneumonia was retrieved from PubMed and EMBASE databases. […] The meta-analysis result showed that the most common clinical symptoms of the novel coronavirus pneumonia were fever (91.6%) and cough (64.5%), followed by dyspnea (32.8%) and sputum (28.1%). […] Headache (10.5%), sore throat (11.2%), hemoptysis (3.2%), diarrhea (6.6%) and the other symptoms were relatively rare. […] Heterogeneity between studies was significant; however, subgroup and sensitivity analysis had failed to identify clear sources of heterogeneity. Conclusion: Fever, cough and liver dysfunction are the main clinical manifestations of this disease and the mortality rate is low. 目的： 自2019年12月首次报道新型冠状病毒肺炎以来，该传染病已迅速发生于全国各地及海外多个国家。 | 2020-04-20 |
| 32306755 | To explore the clinical and dynamic computed tomography features of coronavirus disease 2019. […] Symptoms were fever, cough, chest tightness, dyspnea, fatigue, and muscle pain. […] Coronavirus disease 2019 has certain clinical characteristics and typical computed tomography features. | 2020-04-20 |
| 32306822 | Potential compounds were screened from the CHEMBL database, ZINC database, FDA approved drugs and molecules under clinical trials. | 2020-05-14 |
| 32306836 | Thousands of compounds including approved drugs and drugs in the clinical trial are available in the literature. | 2020-05-06 |
| 32306853 | Our RT-LAMP assay is simple to perform, less expensive, time-efficient, and can be used in clinical laboratories for preliminary detection of SARS-CoV-2 in suspected patients. | 2020-05-19 |
| 32306864 | Here, we conducted a serial investigation on 21 individuals infected with SARS-CoV-2 in two medical centres from Jiangsu Province, including 11 non-severe COVID-19 patients, and 5 severe COVID-19 patients and 5 asymptomatic carriers based on nucleic acid test and clinical symptoms. […] Such information is of immediate relevance and would assist COVID-19 clinical diagnosis, prognosis and vaccine design. | 2020-05-05 |
| 32307014 | The consensus produced 18 recommendations which are being used to guide clinical work. | 2020-04-23 |
| 32307115 | The pathogen is spread by human-to-human transmission via droplets exposure and contact transfer, causing mild symptoms in the majority of cases, but critical illness, bilateral viral pneumonia, and acute respiratory distress syndrome (ARDS) in a minority. | 2020-05-02 |
| 32307151 | This consensus document has been prepared on evidence-informed guidelines developed by a multidisciplinary panel of health care providers from four Spanish scientific societies (Spanish Society of Intensive Care Medicine [SEMICYUC], Spanish Society of Pulmonologists [SEPAR], Spanish Society of Emergency [SEMES], Spanish Society of Anesthesiology, Reanimation, and Pain [SEDAR]) with experience in the clinical management of patients with COVID-19 and other viral infections, including SARS, as well as sepsis and ARDS. […] The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. | 2020-05-21 |
| 32307189 | Twenty cases who were confirmed positive for COVID-19 and had none of the known symptoms for this viral infection formed the test group. […] Patients who had definite symptoms of COVID-19 infection as well as those who had a history of hearing loss or a history of any known cause of hearing loss were excluded from the examined sample. | 2020-04-23 |
| 32307192 | Medicare has recently allowed “broad flexibilities to furnish services using remote communications technology to avoid exposure risks to health care providers, patients, and the community.” [1] The implementation of telemedicine, or virtual, services, will help the Otolaryngologists provide needed care to patients while mitigating the clinical and financial impact of the pandemic. | 2020-04-22 |
| 32307245 | Despite the worsening trends of COVID-19, no drugs are validated to have significant efficacy in clinical treatment of COVID-19 patients in large-scale studies. […] A large-scale study investigating the clinical efficacy of remdesivir (200 mg on day 1, followed by 100 mg once daily) is on-going. […] Another promising alternative is hydroxychloroquine (200 mg thrice daily) plus azithromycin (500 mg on day 1, followed by 250 mg once daily on day 2-5), which showed excellent clinical efficacy on Chinese COVID-19 patients and anti-SARS-CoV-2 potency in vitro. | 2020-05-02 |
| 32307265 | Nevertheless, patients without clinical or radiological (CT scan) markers of COVID-19, and with negative nasopharyngeal sample within 24h of surgery, are at low risk of being infected. | 2020-05-22 |
| 32307298 | HLH with cerebral involvement should be considered in patients presenting with severe systemic inflammatory response syndrome (SIRS) but negative cultures and unusual or unexpectedly severe clinical and/or radiologic signs of cerebral dysfunction. | 2020-04-23 |
| 32307313 | The models used to compensate the total dose in case of temporary treatment interruption are well known but it is of importance in that pandemic context to update and homogenize clinical practice in order to improve local control without increasing normal tissue complications. | 2020-04-26 |
| 32307322 | The clinical characteristics and spectrum are still unknown. […] A random effects model was used to pool clinical data in the meta-analysis. […] Gastrointestinal symptoms (12%) were uncommon. | 2020-05-13 |
| 32307519 | The patient developed symptoms on 3rd March while staying in Miami where he arrived on 12th February. | 2020-04-30 |
| 32307550 | Here, we investigated the clinical, cytokine levels, T cell proportion and related gene expression occurring in COVID-19 patients on admission and after intial treatment. 11 patients diagnosed as COVID-19 with similar initial treatment regimen were enrolled in the hospital. […] Cough and fever were the top symptoms in the 11 COVID-2019 cases. | 2020-04-30 |
| 32307593 | Since the 2019 novel coronavirus disease (COVID-19) outbreak originated from Wuhan, Hubei Province, China, at the end of 2019, it has become a clinical threat to the general population worldwide. | 2020-04-23 |
| 32307653 | Clinical tests with allogeneic MSCs from healthy individuals are underway to enhance endogenous lung repair and suppress inflammation. | 2020-05-29 |
| 32308263 | Recent clinical trials to rescue Tex show promising outcomes. | 2020-04-23 |
| 32308494 | Most studies to date on COVID-19 have focused on disease etiology and the genomics of 2019-nCoV, with few reports on the epidemiologic and clinical characteristics of infected patients. […] We report early clinical features of 26 patients with confirmed COVID-19 who were admitted to Liaocheng Infectious Disease Hospital in Shandong Province. | 2020-04-23 |
| 32308532 | We describe the clinical and epidemiological aspects of the first two confirmed COVID-19 cases in the Philippines, both admitted to the national infectious disease referral hospital in Manila. […] Patient 1, a 39-year-old female, had symptoms of cough and sore throat and was admitted to San Lazaro Hospital in Manila on January 25. […] Her symptoms resolved, and she was discharged. […] Patient 2, a 44-year-old male, had symptoms of fever, cough, and chills. Influenza B and Streptococcus pneumoniae were detected by PCR on initial NPS/OPS swabs. […] This case report highlights several important clinical and public health issues. […] Despite both patients being young adults with no significant past medical history, they had very different clinical courses, illustrating how COVID-19 can present with a wide spectrum of disease. | 2020-04-23 |
| 32308732 | Thus, we aimed to explore TCM characteristics of clinical efficacy to NCP, as well as to optimize Qingfei Paidu decoction (QFPDD) and the recommended formulas to NCP by National Health Commission (NHC). […] Chinese medical sciences theory and clinical application of TCM were analyzed. […] A total of 54 NCP patients were observed in a hospital from Wuhan, whose clinical characteristics and utilization of Chinese Medicines (CMs) were described. […] TCM has a systemic theoretical understanding on the pathological evolution and a positive clinical efficacy on NCP. | 2020-04-23 |
| 32309266 | The most common manifestation is flu-like symptoms. […] Gastrointestinal symptoms are less common but possible and more difficult to recognize as part of a COVID-19 syndrome. […] We report the cases of COVID-19 patients admitted to our Emergency Department who complained of gastrointestinal symptoms at admission. […] The novel COVID-19 infection is a severe public health problem which is causing an increasing number of deaths worldwide.Although uncommon, there may be a relationship between gastrointestinal symptoms and COVID-19, as reported in recent studies.Early detection and isolation of patients with COVID-19 infection is the only way to control and limit the global spread of this virus. | 2020-04-22 |
| 32309267 | We describe two elderly patients evaluated at emergency departments for anosmia/dysgeusia in the absence of any other respiratory symptoms prior to or upon admission. […] In the current epidemiological context, clinical and biological work-up led to a diagnosis of COVID-19 infection. […] In the current epidemiological situation, anosmia and dysgeusia in the absence of other respiratory conditions should be carefully evaluated.Special attention should be given to patients with non-classic COVID-19 symptoms in order to reduce transmission and protect health providers. | 2020-05-27 |
| 32309388 |
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2020-04-23 |
| 32309679 | The COVID-19 pandemic has resulted in a proliferation of clinical trials that are designed to slow the spread of SARS-CoV-2, the virus that causes COVID-19. […] Here we have provided a foundation for cardiovascular and cardio-oncology physicians who are on the frontline providing care to COVID-19 patients, so that they can better understand the emerging cardiovascular epidemiology of COVID-19, as well as the biological rationale for the clinical trials that are ongoing for the treatment of COVID-19 patients. | 2020-05-31 |
| 32309809 | In addition, clinical trials on the efficacy of antiviral therapies in the management of Severe Acute Respiratory Syndrome coronavirus (SARS-Cov) or Middle East Respiratory Syndrome coronavirus (MERS-CoV) have also been reviewed, in order to identify potential treatment options for COVID-19. […] Only one clinical trial on the efficacy of antiviral therapy in management of COVID-19 was found. […] In addition, no clinical trials were found to be performed on the efficacy of antiviral agents in the management of SARS-CoV and MERS-CoV. […] In the time of the current pandemic and future epidemics, organizations such as WHO should pursue more proactive actions and plan well-designed clinical trials so that their results can be used in managing future epidemics. | 2020-04-23 |
| 32309810 | In this study, we reported 8 incidentally detected cases of COVID-19 pneumonia in chest computed tomography (CT) scan of patients referred to emergency department following multiple trauma without any respiratory symptoms. | 2020-04-23 |
| 32309812 | SARS-CoV-2 virus causes a pneumonia that was identified through fever, dyspnea, and acute respiratory symptoms and named COVID-19. | 2020-04-23 |
| 32310621 | In humans, CoVs mostly cause respiratory and gastrointestinal symptoms. […] Clinical manifestations range from a common cold to more severe disease such as bronchitis, pneumonia, severe acute respiratory distress syndrome, multi-organ failure and even death. […] SARS-CoV, MERS-CoV and SARS-CoV-2 seem to less commonly affect children and to cause fewer symptoms and less severe disease in this age group compared with adults, and are associated with much lower case-fatality rates. […] Preliminary evidence suggests children are just as likely as adults to become infected with SARS-CoV-2 but are less likely to be symptomatic or develop severe symptoms. […] Children more often have gastrointestinal symptoms compared with adults. […] The majority of children infected by novel CoVs have a documented household contact, often showing symptoms before them. […] In this review, we summarize epidemiologic, clinical and diagnostic findings, as well as treatment and prevention options for common circulating and novel CoVs infections in humans with a focus on infections in children. | 2020-04-24 |
| 32310815 | Therefore, more flexible options for screening for SARS-CoV-2 RNA and serologic responses are critical to inform clinical and public health responses. […] Providers will record whether they are confident in the suitability of the specimen for laboratory testing that would inform clinical decision making. | 2020-04-30 |
| 32310915 | However, there is no clinical evidence to support this hypothesis. […] In the light of the above considerations, it is reasonable to conclude that the suggestion to discontinue ACE-inhibitors or ARBs in all patients with the aim of preventing or limiting the diffusion of SARS-CoV-2 virus is not based on clinical evidence. […] Controlled clinical studies in this area are eagerly awaited. | 2020-04-22 |
| 32310916 | Some pathophysiological reasons have been hypothesized regarding the frequently observed increase in troponin levels in patients hospitalized with COVID-19, but, at the moment, these data could already suggest some clinical management implications, also with the aim of prospectively collecting research data: a troponin dosage should be considered, as a prognostic indicator, in all patients with moderate/severe COVID-19 at hospital admission, periodically during hospitalization, and in the case of clinical deterioration. […] In those patients with increased troponin levels, serial determinations should be carried out to define the enzymatic trajectory and therefore also the degree of clinical attention that must necessarily be closer in those who turn out to have persistently high or increasing troponin levels. | 2020-04-22 |
| 32310920 | The integrated clinical, laboratory and ultrasound approach is essential for the diagnosis, monitoring and evaluation of the patient’s therapy in COVID-19 pneumonia. | 2020-04-22 |
| 32310921 | Our opinion is that a syndemic approach, which considers the complex interplay between social, economic, environmental and clinical problems, can be the most appropriate and achieved by means the contribution of telemedicine and telecardiology, intended as integration and not as an alternative to traditional management. […] A flexible use of telematic tools, now available for teleconsultation, and/or remote monitoring adapted to the needs of clinical, family and social-health contexts could allow the creation of integrated and personalized management programs that are effective and efficient for the care of patients. | 2020-04-22 |
| 32311109 | To analyse the clinical prognosis of discharged COVID-19 patients by monitoring their SAR-CoV-2 nucleic acid status, which may provide evidence to establish discharge standards and follow-up management for COVID-19 patients. […] The patient’s daily clinical signs were recorded and sputum and faecal specimens were regularly sent for the detection of SARS-CoV-2 nucleic acid. […] The time between initial symptoms and meeting discharge criteria was 18 - 44 days with an average of 25 ± 6 days. | 2020-04-20 |
| 32311151 | Under the outbreak of COVID-19, it was urgent to analyze the cases from clinical features and epidemiological factors, as well as understand the effectiveness of measures taken on disease prevent and control. […] A retrospective study was applied for descriptive analysis of clinical features and epidemiological factors of confirmed cases in four cities of Zhejiang. […] Clinical features of fever and cough were found mostly happen on patients. | 2020-05-22 |
| 32311318 | Since the outbreak of coronavirus disease 2019 (COVID-19), clinicians have tried every effort to understand the disease, and a brief portrait of its clinical features have been identified. […] In clinical practice, we noticed that many severe or critically ill COVID-19 patients developed typical clinical manifestations of shock, including cold extremities and weak peripheral pulses, even in the absence of overt hypotension. […] Understanding the mechanism of viral sepsis in COVID-19 is warranted for exploring better clinical care for these patients. | 2020-05-12 |
| 32311350 | This study aimed to conduct a systematic review of the clinical outcomes reported for pregnant patients with coronavirus disease 2019. […] Coronavirus disease 2019 associated with respiratory insufficiency in late pregnancies certainly creates a complex clinical scenario. | 2020-05-16 |
| 32311437 | However, there are few reports on clinical application of 2019-nCoV nucleic acid detection in other biological samples. […] COVID-19 diagnostic criteria: according to China’s ⟪pneumonia diagnosis and treatment Program of novel coronavirus infection (trial version 7) ⟫, in accordance with the relevant epidemiological and clinical manifestations, nasopharyngeal swabs real-time fluorescence RT-PCR detection of 2019-nCoV nucleic acid positive, COVID-19 cases were divided into mild, ordinary, severe and severe [1]. […] Simple detection of nasopharyngeal swab 2019-nCoV nucleic acid detection positive rate is not high, multi-sample 2019-nCoV nucleic acid detection can improve the accuracy, reduce the false negative rate, better guide clinical treatment and evaluate the therapeutic effect. | 2020-05-13 |
| 32311451 | The infected patients presented with fever, respiratory symptoms, sometimes with digestive and other systemic manifestations, and some progressed with a severe acute respiratory syndrome or even death. […] Associated digestive symptoms were frequently observed in the patients, with an unknown significance and mechanism. […] We collected the clinical data of the 2019-nCoV-infected patients from published studies and extracted the data about the incidence of gastrointestinal symptoms. […] Furthermore, we used online datasets to analyze ACE2 expression in different human organs, especially in the small intestine, to explore the relationship between ACE2 expression patterns and clinical symptoms. […] High expression of ACE2 on the surface cells in the digestive tract may lead to gastrointestinal symptoms and inflammation susceptibility. […] Overall, digestive symptoms were common in the COVID-19 patients. […] It is a possible mechanism of digestive symptoms in the COVID-19 patients and explains the presence of the virus in patients’ stool samples. | 2020-05-31 |
| 32311512 | We compared clinical, laboratory, radiological, and outcome features of patients with SARS-CoV-2 infection (COVID-19) with pneumonia, with vs without diarrhea. | 2020-05-28 |
| 32311643 | In the midst of the epidemic in Italy, the CIPOMO promoted a national survey aiming to evaluate the impact of COVID-19 on clinical activity of oncologists and the implementation of containment measures of COVID-19 diffusion. | 2020-05-29 |
| 32311650 | We aimed to study the epidemiology, clinical features and short-term outcomes of patients with COVID-19 in Wuhan, China. […] Most common symptoms in severe patients were high fever, anorexia and dyspnea. […] As of February 15, 2020, 19.0% patients had been discharged and 5.4% patients died. 80% of severe cases received ICU (intensive care unit) care, and 52.3% of them transferred to the general wards due to relieved symptoms, and the mortality rate of severe patients in ICU was 20.5%. […] Patients with elder age, chronic comorbidities, blood leukocyte/lymphocyte count, procalcitonin level, co-infection and severe complications might increase the risk of poor clinical outcomes. | 2020-05-27 |
| 32311668 | Considering the clinical impact of the new outbreak, it is highly important to study the potential responses of the human immune system during the SARS-CoV-2 infection as well as the role of virus-specific T cells and by B-lymphocytes. | 2020-05-28 |
| 32311771 | We propose that transmission is associated with time in proximity to severe acute respiratory syndrome coronavirus-1 patients with respiratory symptoms, rather than the procedures per se. | 2020-05-08 |
| 32311790 | A total of 138 medical records of critically ill patients with COVID-19 were included in the study. […] Demographic and clinical characteristics on admission used for calculating Modified Early Warning Score (MEWS) and Rapid Emergency Medicine Score (REMS) and outcomes (survival or death) were collected for each case and extracted for analysis. | 2020-05-21 |
| 32311816 | This document addresses the care of these patients focusing on (a) varied clinical presentations; (b) appropriate personal protection equipment (PPE) for health care workers; (c) the roles of the emergency department, emergency medical system, and the cardiac catheterization laboratory (CCL); and (4) regional STEMI systems of care. | 2020-05-14 |
| 32311826 | Like SARS and MERS, COVID-19 infection manifests most frequently with lower respiratory symptoms. […] In addition to its central role in the diagnosis of COVID-19 infection, the clinical laboratory provides critical information to clinicians regarding prognosis, disease course, and response to therapy. | 2020-04-20 |
| 32311836 | Participants in a US-wide longitudinal observational registry responded to a supplemental COVID-19 questionnaire by e-mail on March 25, 2020, about their symptoms, COVID-19 testing, health care changes, and related experiences during the prior 2 weeks. […] Analysis compared responses by diagnosis, disease activity, and new onset of symptoms. | 2020-05-09 |
| 32311843 | One of the most important clinical features of the infection is a profound coagulopathy. | 2020-04-20 |
| 32312018 | The distribution and morphology of lesions on chest CT, clinical data will be recorded. | 2020-04-23 |
| 32312025 | While sensitive for detecting lung parenchymal abnormalities in COVID-19 pneumonia, CT for initial diagnosis is discouraged and should be reserved for specific clinical indications. […] Interpretation of chest CT findings should be correlated with duration of symptoms to better determine the disease stage and aid in patient management. | 2020-04-21 |
| 32312064 | As two important means of examination, computed tomography (CT) and real-time reverse transcription polymerase chain reaction (RT-PCR) have always been controversial in the clinical diagnosis of COVID-19 pneumonia. […] Here, we report a family cluster case of a father and a son diagnosed as COVID-19 at our hospital, and described the clinical manifestations, laboratory results, CT changes, diagnosis and treatment strategy of these two patients. […] For patient 2 (son), the clinical symptoms were not obvious, but CT imaging clearly displayed dynamic changes of the lung lesions. […] Therefore, in clinical work, doctors should make full use of the advantages of CT and RT-PCR, and take other measures to make up for their disadvantages. | 2020-04-21 |
| 32312158 | The decrease in clinical opportunities due to the limitations on elective surgical cases and office visits as well as potential resident redeployment could lead to a decline in overall experience as well as key indicator cases. | 2020-04-21 |
| 32312163 | Immediate measures to reduce transmission rates and protect patients and providers take priority and necessitate some delays in care, particularly for patients with mild symptoms or less aggressive cancers. | 2020-04-21 |
| 32312362 | The Subspecialty Group of Endocrinology and Metabolism, Society of Pediatrics, Chinese Medical Association and the Subspecialty Group of Endocrinology and Metabolism, Society of Pediatrics, Chinese Medical Doctor Association have developed the recommendations on the identification and transfer of children with critical diabetes during the COVID-19 outbreak, which provide a reference for primary doctors to quickly assess the severity of patient’s condition and treat the illness accordingly, thus reducing the risk of referral infection and improving clinical prognosis. | 2020-04-22 |
| 32312363 | To study the clinical features of children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. […] A retrospective analysis was performed for the clinical data of 115 children who were diagnosed with SARS-CoV-2 infection in the Wuhan Children’s Hospital, including general information, history of close contact with individuals of SARS-CoV-2 infection, early clinical symptoms, laboratory examination results, and lung CT results. […] As for clinical symptoms, 29 children (25.2%) had fever, 47 (40.9%) had respiratory symptoms (including cough, rhinorrhea, and nasal congestion), and 61 (53.0%) were asymptomatic. | 2020-04-22 |
| 32312364 | To study the clinical features of children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. […] A retrospective analysis was performed for the clinical data of 13 children with SARS-CoV-2 infection who hospitalized in a Changsha hospital. […] Of the 13 children, 2 had no symptoms, and the other 11 children had the clinical manifestations of fever, cough, pharyngeal discomfort, abdominal pain, diarrhea, convulsions, or vomiting. […] As for clinical typing, 7 had mild type, 5 had common type, and 1 had severe type. […] Mild and common types are the major clinical types in children with SARS-CoV-2 infection, and cytokine storm is not observed. | 2020-04-22 |
| 32312365 | In addition to the typical respiratory symptoms, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection also has the clinical symptoms of cardiovascular system damage. | 2020-04-22 |
| 32312544 | We provide treatment advice as a pragmatic perspective on the risk/benefit ratio in specific clinical scenarios. | 2020-05-28 |
| 32312567 | They should also be trained to prevent, detect and treat early warning symptoms of post-traumatic stress disorder, because their prevalence was high in the regions of China most affected by the pandemic. | 2020-05-08 |
| 32312571 | Clinical information on airway management and expert recommendations in these patients are urgently needed. […] Based on clinical information and expert recommendation, we propose detailed planning, strategy, and methods for tracheal intubation in COVID-19 patients. | 2020-05-02 |
| 32312574 | The overlap in the signs and symptoms of COVID-19 associated Acute Respiratory Distress Syndrome (ARDS) and COVID-19 with concurrent pulmonary embolism creates a diagnostic challenge for emergency medicine physicians in patients already at risk for renal impairment. […] Additionally, the presence of right heart strain on electrocardiography (EKG) is a well described clinical presentations of pulmonary embolism not reported commonly with COVID-19 infections. | 2020-04-26 |
| 32312600 | This consensus document has been prepared on evidence-informed guidelines developed by a multidisciplinary panel of health care providers from four Spanish scientific societies (Spanish Society of Intensive Care Medicine [SEMICYUC], Spanish Society of Pulmonologists [SEPAR], Spanish Society of Emergency [SEMES], Spanish Society of Anesthesiology, Reanimation, and Pain [SEDAR]) with experience in the clinical management of patients with COVID-19 and other viral infections, including SARS, as well as sepsis and ARDS. […] The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. | 2020-04-21 |
| 32312628 | Coronaviruses can cause multiple systemic infections that respiratory complications are the most obvious symptoms. […] In this report, we describe the symptoms of Guillain Barre syndrome (GBS) in one infected patient with COVID-19, for the first time. | 2020-04-23 |
| 32312676 | A nation-wide workgroup drew guidelines based on clinical experience, national and local recommendations and scientific literature. | 2020-05-22 |
| 32312892 | Clinical trials and other research activities are inevitably impacted. […] Regulatory bodies have issued guidance on managing clinical trials during the pandemic, including contingency measures for remote study visits, delivery of investigational product, and site monitoring visits. […] New cancer clinical trial practices during the SARS-CoV-2 pandemic include new risk assessment strategies, decentralized and remote trial coordination, data collection, and delegation of specific therapeutic activities. […] This experience could provide evidence of more feasible and cost-effective methods for future clinical trial conduct. | 2020-05-21 |
| 32313360 | In this regard, it discusses the specific effects of automated decision support systems on public services and the growing expectations for governments to play a more prevalent role in the digital society and to ensure that the potential of technology is harnessed, while negative effects are controlled and possibly avoided. | 2020-04-21 |
| 32313463 | The most common presenting symptoms are fever, cough, dyspnea, and myalgias and/or fatigue. | 2020-04-23 |
| 32313588 | The utility of the noncontrast CT chest in the diagnosis of COVID-19 has been controversial, but there are specific imaging findings that have been increasingly associated with this virus in the appropriate clinical context. | 2020-05-31 |
| 32313785 | Saliva has also been used in screening respiratory viruses among hospitalized patients without pyrexia or respiratory symptoms. […] Salivary diagnostics is a dynamic field that is being incorporated as part of disease diagnosis, clinical monitoring of systemic health and to make significant clinical decisions for patient care. | 2020-04-23 |
| 32313804 | In this review, we discuss the current implications of the changing genomic epidemiology of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), etiological agent of the Coronavirus Disease 2019 (COVID-19) and its potential relationship with the change of clinical manifestations in patients with confirmed infection. […] Simultaneously, also new clinical manifestations are observed, particularly more prominent gastrointestinal and neurological findings. […] SARS-CoV-2/COVID-19 is changing not only its epidemiology, but also its genomic diversity and clinical manifestations, both aspects coupled, needs to be considered in the study of this ongoing pandemic. | 2020-04-23 |
| 32313807 | Clinicians should consider this entity since it may warrant appropriate isolation precautions especially in a patient who may not present primarily with typical constitutional and respiratory symptoms associated with COVID-19. | 2020-05-31 |
| 32313885 | The COVID-19 pandemic has resulted in a proliferation of clinical trials that are designed to slow the spread of SARS-CoV-2, the virus that causes COVID-19. […] Here we have provided a foundation for cardiovascular and cardio-oncology physicians who are on the frontline providing care to COVID-19 patients, so that they can better understand the emerging cardiovascular epidemiology of COVID-19, as well as the biological rationale for the clinical trials that are ongoing for the treatment of COVID-19 patients. | 2020-05-22 |
| 32313886 | Somatic symptom disorder (SSD) is characterized by a dysfunctional preoccupation with physical symptoms leading to excessive and unnecessary healthcare utilization. […] We report a detailed clinical case of a 16 years old adolescent, who presented with a history suggestive of COVID-19 infection and associated psychological distress. […] When COVID-19-like symptoms occur, we highlight the importance of differentially diagnosing a possible exacerbation of a pre-existing SSD, triggered by fear of being infected. | 2020-05-20 |
| 32314010 | Her symptoms and laboratory results gradually improved. | 2020-05-04 |
| 32314249 | Patients developed their symptoms (fever, cough, dyspnea, and fatigue) 1, 2, 4, and 14 days after surgery. | 2020-04-23 |
| 32314274 | Changes in clinical features, laboratory characteristics, and imaging features of pregnant women during the pre-partum and post-partum periods require further elucidation. […] Here, we retrospectively analyzed the clinical features, laboratory characteristics, and imaging features of eight pregnant cases of SARS-CoV-2 infection during the pre-partum and post-partum periods. | 2020-05-08 |
| 32314329 | A similar effect of SARS-CoV-2 could partly explain risk factors and symptoms, and could potentially be treatable. | 2020-04-27 |
| 32314436 | Having been infected by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), patients with COVID-19 mainly present with fever and respiratory symptoms (2). | 2020-04-21 |
| 32314460 | We discuss the available data on cutaneous symptoms, although disease-specific symptoms have yet not been observed. […] The consequences for systemic treatment are obvious but it will be most important to collect the clinical data for a better decision process. | 2020-05-22 |
| 32314483 | Previous coronaviruses outbreaks reports, current published evidences on pathogenesis and on clinical reports of COVID infection in immunosuppressed patients are used to make a scientifically based decision. | 2020-05-22 |
| 32314685 | He presented initially with vague gastrointerestinal symptoms and later a cough. […] Subsequently, the patient’s clinical status improved, and after 8 days of hospitalization, he was transferred out of the country, where he recovered. | 2020-04-21 |
| 32314790 | Coronaviruses contribute to the burden of respiratory diseases in children, frequently manifesting in upper respiratory symptoms considered to be part of the “common cold.” Recent epidemics of novel coronaviruses recognized in the 21st century have highlighted issues of zoonotic origins of transmissible respiratory viruses and potential transmission, disease, and mortality related to these viruses. | 2020-05-04 |
| 32314799 | Given the paucity of robust clinical trial data for most COVID-19 pharmacotherapies at this time, clinicians should continue to remain steadfast in recognition of interventions that improve clinical outcomes and vigilant in monitoring for acute adverse effects that are difficult to detect in clinical trials with small sample sizes. | 2020-05-12 |
| 32314805 | We systematically reviewed the computed tomography (CT) imaging features of coronavirus disease 2019 (COVID-19) to provide reference for clinical practice. | 2020-04-29 |
| 32314808 | I have read with great interest the article “COVID-19 patients’ clinical characteristics, discharge rate, and fatality rate of meta-analysis” by Li and colleagues1 . […] The authors have conducted a comprehensive search for articles concerning the clinical characteristics of Chinese patients with COVID-19. | 2020-04-21 |
| 32314810 | Our observations of virus in neural tissue, in conjunction with clinical correlates of worsening neurologic symptoms, pave the way to a closer understanding of the pathogenic mechanisms underlying CNS involvement by SARS-CoV-2. | 2020-05-20 |
| 32315076 | The COVID-19 pandemic has massively disrupted essential clinical research. […] The objective was to study older participants’ and their caregivers’ perspectives to participate in ongoing clinical research during the COVID-19 pandemic. […] VISN-16/Geriatric Research, Education and Clinical Center (GRECC), Department of Veterans Affairs. […] Older participants and their caregivers (N = 51) enrolled in ongoing clinical research studies. | 2020-05-05 |
| 32315079 | We hereby present a case of COVID-19-associated varicella-like exanthem in an 8-year-old girl with mild systemic symptoms. | 2020-05-19 |
| 32315122 | In this report, we present a dual-organ (heart/kidney) transplant recipient who was found to have COVID-19 and, despite the presence of a number of risk factors for poor outcomes, had a relatively mild clinical course. | 2020-04-21 |
| 32315171 | Taking advantage of a recently released crystal structure of SARS-CoV-2 main protease in complex with a covalently bonded inhibitor, N3 (Liu et al., 10.2210/pdb6LU7/pdb), I conducted virtual docking screening of approved drugs and drug candidates in clinical trials. | 2020-05-07 |
| 32315386 | Common symptoms of pandemic coronavirus disease (COVID-19) include fever and cough. […] We describe a 94-year-old man with well-controlled schizoaffective disorder, who presented with non-specific and atypical symptoms: delirium, low-grade pyrexia and abdominal pain. […] This has implications for the screening, assessment and isolation of frail older people to COVID-specific clinical facilities and highlights the potential for spread among healthcare professionals and other patients. | 2020-04-30 |
| 32315487 | In this study we report on the clinical and autoimmune characteristics of severe and critical novel coronavirus pneumonia caused by severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2). […] The clinical, autoimmune, and laboratory characteristics of 21 patients who had laboratory-confirmed severe and critical cases of coronavirus disease 2019 (COVID-19) from the intensive care unit of the Huangshi Central Hospital, Hubei Province, China, were investigated. […] Cough (90.5%) and fever (81.0%) were the dominant symptoms, and most patients (76.2%) had at least one coexisting disorder on admission. […] We also retrospectively analyzed the clinical and laboratory data from 21 severe and critical cases of COVID-19. | 2020-05-14 |
| 32315614 | We tried to find some useful information by analyzing the covid-19 screening data, so as to provide help for clinical practice. | 2020-05-30 |
| 32315723 | Based on the published data, this review systematically discusses the etiology, epidemiology, clinical characteristics, and current intervention measures related to COVID-19 in the hope that it may provide a reference for future studies and aid in the prevention and control of the COVID-19 epidemic. | 2020-05-16 |
| 32315725 | We found a significant decrease of T lymphocyte subsets and an increase of inflammatory cytokines of hospitalized patients with COVID-19 in clinical practice. […] Demographic, clinical, laboratory information, especially T lymphocyte subsets and inflammatory cytokines were reported. | 2020-04-26 |
| 32315756 | Presently, the World Health Organization indicates that the fatality rate due to COVID-19 is about 2%, inferring that many positive subjects may potentially overcome the illness with mild influenza-like symptoms and no need for hospitalization at intensive-care units. | 2020-05-03 |
| 32315817 | Medline, SinoMed, EMBASE, and Cochrane Library were searched for clinical and epidemiological studies on confirmed cases of COVID-19. […] The incidence of fever, cough, fatigue, and dyspnea symptoms were 85.6 % (95CI 81.3-89.9 %), 65.7 % (95CI 60.1-71.4 %), 42.4 % (95CI 32.2-52.6 %) and 21.4 % (95CI 15.3-27.5 %). | 2020-05-27 |
| 32315980 | However, it has been speculated that overactive immune response could drive clinical deterioration and, based on this hypothesis, several immunosuppressants are currently being tested as potential treatment for COVID-19. […] Despite complete B cell depletion, patient symptoms abated few days after hospitalization, and he was discharged to home-quarantine. […] Phone interview follow-up confirmed that, after 14 days, no new symptoms occurred. | 2020-05-26 |
| 32316270 | Besides the ethical concern related to accelerated large-scale clinical trials of drugs with unproven efficacy, the known potential detrimental cardiac effects of these drugs should also be considered. | 2020-04-23 |
| 32316618 | Symptoms of COVID-19 include fever (88%), cough (68%), vomiting (5%) and diarrhoea (3.7%), and transmission of SARS-CoV-2 is thought to occur from human to human via respiratory secretions released by the infected individuals when coughing and sneezing. […] The purpose of this review is to provide a comprehensive update on the pathogenesis, clinical aspects, diagnosis, challenges and treatment of SARS-CoV-2 infections. | 2020-05-29 |
| 32316712 | Nearly one third of patients developed new symptoms or exacerbation of existing symptoms. | 2020-05-16 |
| 32316713 | With comprehensive analysis of relevant literature, this paper reviews the clinical characteristics of neoplastic patients with COVID-19, and puts forward some suggestions on how to deal with this epidemic. | 2020-04-24 |
| 32316718 | Four of them are “calls for action”, 3 provide recommendations about rehabilitation interventions in the acute phase, 2 address the needs of people quarantined at home or with restricted mobility due to the lockdown, and 1 provides a Core Outcome Set to be used in clinical trials to test the efficacy of health strategies in managing Covid-19 patients. | 2020-04-22 |
| 32317038 | Each subscriber receives free daily supportive text messages, for 3 months, crafted by a team of clinical psychologists, psychiatrists, mental health therapist, and mental health service users. | 2020-05-07 |
| 32317050 | However, they lack diversity and are almost non-existent in some study fields, such as clinical research. […] The findings suggest that evidence for the development of clinical practice guidelines and public health policies will be improved when more results from clinical research becomes available. | 2020-04-24 |
| 32317180 | To evaluate the clinical features and outcomes of COVID-19 pneumonia in kidney transplant recipients. […] The clinical outcomes (the severity of pneumonia, recovery rate, time of virus shedding, and length of illness) were compared with the control group by statistical analysis. […] The clinical symptomatic, laboratory, and radiological characteristics of COVID-19 pneumonia in the renal transplant recipients were similar to those of severe COVID-19 pneumonia in the general population. […] Kidney transplant recipients had more severe COVID-19 pneumonia than the general population, but most of them recovered after a prolonged clinical course and virus shedding. | 2020-05-28 |
| 32317205 | Our experience highlights the importance of the use of a multidisciplinary therapeutic approach that tailors to the specific condition of the patient in achieving a favorable clinical outcome. | 2020-04-24 |
| 32317225 | While clinical reports from China to date demonstrate that the majority of cases remain relatively mild and recover with supportive care, it is also crucial to be well prepared for severe cases warranting intensive care. | 2020-04-24 |
| 32317267 | Epidemiological, clinical, and laboratory characteristics and treatment and outcomes data were obtained through data collection forms from electronic medical records, and the relation between clinical data and disease severity was analysed. 3497 respiratory, stool, serum, and urine samples were collected from patients after admission and evaluated for SARS-CoV-2 RNA viral load. | 2020-04-24 |
| 32317402 | Although immunosuppressed individuals are thought to be at an increased risk of severe disease, little is known about their clinical presentation, disease course, or outcomes. […] We report 15 kidney transplant recipients from the Columbia University kidney transplant program who required hospitalization for confirmed COVID-19, and describe their management, clinical course, and outcomes. | 2020-05-30 |
| 32317434 | Of those who were still examining patients, 82.9% (287/347) were only seeing emergency cases, based on their own clinical judgement. | 2020-04-27 |
| 32317557 | The purpose of this manuscript is to review our initial clinical experience in 32 patients with confirmed COVID-19 treated with ECMO.A multi-institutional registry and database was created and utilized to assess all patients who were supported with ECMO provided by SpecialtyCare. […] Additional patient experience and associated clinical and laboratory data must be obtained to further define the optimal role of ECMO in patients with COVID-19 and ARDS. | 2020-05-15 |
| 32317808 | The clinical knowledge about the course, complications and treatment of COVID-19 in children and adolescents is so far limited. […] This systematic review summarizes the current scientific evidence regarding the clinical presentation of COVID-19 in hospitalized children based on available case series from China. […] Most commonly reported symptoms were fever and cough; in 40-100% of cases involvement of the lower respiratory tract was reported, usually confirmed by computed tomography (CT). | 2020-04-24 |
| 32317810 | Hence, the experiences from the clinical intervention for that region should be considered in control and treatment strategies. | 2020-04-24 |
| 32318325 | The objectives of this study were to analyze the clinical features of coronavirus disease 2019 (COVID-19) and evaluate the diagnosis and treatment. […] A retrospective analysis of the clinical manifestation and auxiliary examination of 19 patients with COVID-19 from the Liyuan Hospital intensive care unit (ICU) between January 16, 2020 and February 20, 2020 was undertaken. […] The clinical laboratory indices change significantly, especially the D-dimer level among non-survivors. | 2020-04-24 |
| 32318327 | Effective antivirals with safe clinical profile are urgently needed to improve the overall prognosis. […] In a proof-of-concept trial involving 31 patients with COVID-19, DIP supplementation was associated with significantly decreased concentrations of D-dimers (P<0.05), increased lymphocyte and platelet recovery in the circulation, and markedly improved clinical outcomes in comparison to the control patients. […] In particular, all 8 of the DIP-treated severely ill patients showed remarkable improvement: 7 patients (87.5%) achieved clinical cure and were discharged from the hospitals while the remaining 1 patient (12.5%) was in clinical remission. | 2020-04-24 |
| 32318665 | Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2, and then analyzed by clinical signs, viral replication, chest X-ray, histopathological changes and immune response. | 2020-05-19 |
| 32318703 | Epidemiological and clinical characteristics from the 26 asymptomatic patients with positive results for SARS-CoV-2 RNA testing were obtained. | 2020-04-30 |
| 32318706 | Antivirals should preferably be used as part of a clinical trial if available. | 2020-05-14 |
| 32318916 | To investigate the chest CT imaging characteristics and clinical manifestations of patients with COVID-19 pneumonia. […] This study included 150 patients with COVID-19 pneumonia diagnosed from January 10 to February 12, 2020 to analyze their clinical and CT imaging characteristics. | 2020-05-29 |
| 32319041 | The results of this cross-sectional study suggest that nearly 40.4% the sampled youth were found to be prone to psychological problems and 14.4% the sampled youth with Post-traumatic stress disorder (PTSD) symptoms. | 2020-05-08 |
| 32319118 | The recent SARS-CoV-2 pandemic, which has recently affected Italy since February 21, constitutes a threat to normal subjects, as the coronavirus disease-19 (COVID-19) can manifest with a broad spectrum of clinical phenotypes ranging from asymptomatic cases to pneumonia or even death. […] When the SARS-CoV-2 epidemic has reached Italy, we have activated a surveillance protocol of patients with IEI, to perform SARS-CoV-2 search by nasopharyngeal swab in patients presenting with symptoms that could be a manifestation of COVID-19, such as fever, cough, diarrhea, or vomiting. | 2020-05-19 |
| 32319129 | At the current stage of knowledge, children have less severe symptoms of COVID-19, and severe asthma and immunodeficiency are classified as risk factors. | 2020-05-20 |
| 32319131 | At the same time, clinical services could be maintained, however, not without deployment of personnel exposed to employees infected with SARS-CoV-2. […] Apart from massive testing of personnel in pre-defined phases and increased hygiene measures, including a general obligation to wear surgical face masks, we identified the need to monitor cases of illness across all groups of employees, to ensure social distancing within personnel and to evaluate contacts of clinical personnel outside of the hospital environment, in order to be able to interpret chains of infections and to disrupt them. | 2020-05-18 |
| 32319218 | In this report, we present a 77-year old patient with a heart transplant under relevant immunosuppressive therapy who was tested positive for SARS-CoV-2 after several days of dyspnoea, dry cough and light general symptoms. […] The patient received an antiviral therapy with hydroxychloroquine showing no further deterioration of the clinical state. | 2020-04-22 |
| 32319433 | Above all, this pandemic force us to review what is essential and really necessary in term of priorities and regulatory process for clinical pharmacological research. […] However, several clinical centres decided to use off label drugs as a standard of care in the absence of efficacy and safety data. […] The lessons we will learn from this emergency may result crucial in redesigning a better way of conducting clinical trials and information on drugs. | 2020-04-24 |
| 32319435 | We still do not have clear what positive criteria can help make clinical decisions in contexts of insufficient resources that force us to make choices. | 2020-04-24 |
| 32319443 | On 6 March 2020, the Italian Society of Anaesthesia Analgesia Resuscitation and Intensive care (SIAARTI) published the document “Clinical Ethics Recommendations for Admission to and Suspension of Intensive Care in Exceptional Conditions of Imbalance between Needs and Available Resources”. | 2020-04-24 |
| 32319444 | They have to apply specific clinical and ethical criteria, in emergency conditions. […] The clinical criteria should include the disease severity, the number and severity of comorbidities, frailty, the organ failures and their stage, the patient’s age, the functional autonomy and cognitive status. […] The patients not admitted to ICU due to clinical reasons and advanced stage diseases should receive a high quality palliative care, to obtain a good symptoms control (mainly dyspnea, anxiety and delirium) and to implement palliative sedation at the end of life. | 2020-04-24 |
| 32319446 | The clinical spectrum of this infection includes, in order of lesser to greater severity, asymptomatic viremia, paucisymptomatic forms, clinical conditions characterized by respiratory failure that needs mechanical ventilation and support in an intensive care unit, systemic manifestations of infection, septic shock, and multiple organ dysfunction syndromes. […] Starting from the pathogenetic mechanisms involved in the development of this infection up to the clinical characteristics of the infected patients, in this review we tried to focus on the crucial points of the infection in combination with the appropriateness of the medical intervention. […] We aim to offer indications of therapeutic intervention that are timely and, as far as possible, effective, targeted to the individual patient in relation to age, clinical condition and comorbidities. | 2020-04-24 |
| 32319971 | Therefore, identifying the early symptoms of COVID-19 is of particular importance and is a health system priority. […] Early studies from COVID-19 outbreak in China have illustrated several non-specific signs and symptoms in infected patients, including fever, dry cough, dyspnea, myalgia, fatigue, lymphopenia, and radiographic evidence of pneumonia (3, 4). | 2020-04-22 |
| 32320003 | To describe the clinical characteristics and outcomes of patients with COVID-19 hospitalized in a US health care system. […] Clinical outcomes during hospitalization, such as invasive mechanical ventilation, kidney replacement therapy, and death. | 2020-05-01 |
| 32320004 | All articles reflected research performed in China, except for 1 clinical case in Singapore. […] Children at any age were mostly reported to have mild respiratory symptoms, namely fever, dry cough, and fatigue, or were asymptomatic. […] To our knowledge, this is the first systematic review that assesses and summarizes clinical features and management of children with SARS-CoV-2 infection. […] The rapid spread of COVID-19 across the globe and the lack of European and US data on pediatric patients require further epidemiologic and clinical studies to identify possible preventive and therapeutic strategies. | 2020-04-22 |
| 32320059 | The safety and efficacy of this strategy should be investigated strictly using animal experiments and clinical trials, and even if the experiments and trials all support the strategy, it should be implemented with enough cautiousness. | 2020-04-22 |
| 32320066 | SARS-CoV-2 shares highly homological sequences with SARS-CoVs causing highly lethal pneumonia with respiratory distress and clinical symptoms similar to those reported for SARS-CoV and MERS-CoV infections. | 2020-04-29 |
| 32320082 | Clinical, laboratory and imaging characteristics of Coronavirus disease 2019 (Covid-19) and risk factors associated with poor outcomes have been reported in various studies.1-2 Nevertheless, information on whether other respiratory pathogens (RP) were co-detected in patients in these series was not provided, despite the fact that coinfections with RP have been reported to occur in this clinical setting.3-6 This article is protected by copyright. | 2020-04-22 |
| 32320375 | We need to use contemporary methods of assessing causality to ensure that clinical, laboratory and public health measures draw on a rational, evidence-based approach to argumentation. | 2020-05-29 |
| 32320477 | The knowledge-driven, model-informed dose selection paradigm can serve as a science-based alternative to recommend pediatric dosing when pediatric clinical trial data is absent. | 2020-05-21 |
| 32320516 | Here, we summarized the current known knowledge regarding epidemiological, pathogenesis, pathology, clinical features, comorbidities and treatment of COVID-19/ SARS-CoV-2 as reference for the prevention and control COVID-19. | 2020-05-07 |
| 32320677 | The sudden clinical deterioration 7-8 days after initial symptom onset suggests that severe respiratory failure (SRF) in COVID-19 is driven by a unique pattern of immune dysfunction. | 2020-04-24 |
| 32320825 | Favilavir is an antiviral drug that is approved in Japan for common influenza treatment and is now approved to treat symptoms of COVID-19 in China. […] The first COVID-19 vaccine is not expected to be ready for clinical trials before the end of the year. | 2020-05-26 |
| 32320852 | In the COVID-19 pandemic, despite being a new virus, there are already drugs suggested as active in in vitro assays that are being repurposed in clinical trials. | 2020-04-29 |
| 32321116 | This review aims to verify the main epidemiologic, clinical, laboratory-related, and therapeutic aspects of coronavirus disease 2019 (COVID-19) in critically ill pediatric patients. […] The report emphasizes on the clinical presentations of the disease and ventilatory support in pediatric patients with COVID-19. […] COVID-19 is essentially an unknown clinical condition for the majority of pediatric intensive care professionals. | 2020-04-27 |
| 32321117 | The world is fighting the COVID-19 outbreak and health workers, including inflammatory bowel diseases specialists, have been challenged to address the specific clinical issues of their patients. […] We hereby summarize the current literature in the management of inflammatory bowel disease (IBD) patients during the COVID-19 pandemic era that support the rearrangement of our IBD unit and the clinical advice provided to our patients. | 2020-04-27 |
| 32321540 | The spectrum of respiratory symptoms may range from mild to severe, strictly depending on the age of the patient and the underlying comorbidities.In children COVID-19 related disease is less frequent and less aggressive. | 2020-04-24 |
| 32321878 | The recent clinical trial reports pertaining to the efficacy of chloroquine and hydroxychloroquine against COVID-19 albeit yet to be validated with larger clinical trials, have sparked much interest globally to evaluate whether this anti-malarial drug can be repurposed for the treatment of COVID-19. | 2020-05-08 |
| 32321903 | In this article, we give a practice of anesthesia scenario design for emergency cesarean section in a supposed standard patient suffering COVID-19, aimed to optimize the work flow and implement the protective details through simulation of a real operation scenario, which may be useful for training and clinical practice of anesthesia management for patients suffering COVID-19 or other fulminating infectious diseases. | 2020-04-23 |
| 32321904 | However, asymptomatic carriers will not be included in confirmed cases unless they develop clinical manifestations while in quarantine. | 2020-04-23 |
| 32321905 | Although infrequent, neuropsychiatric symptoms have been reported in patients who received chloroquine for the treatment of malaria or autoimmune diseases. | 2020-05-22 |
| 32322102 | Our SIDARTHE model discriminates between infected individuals depending on whether they have been diagnosed and on the severity of their symptoms. | 2020-05-01 |
| 32322107 | Based on the literature available at the moment, it can be assumed that the clinical course of COVID-19 disease may be complicated by pregnancy which could be associated with a higher mortality rate. | 2020-04-26 |
| 32322111 | The symptoms, course and outcome all seem to show parallels. | 2020-04-23 |
| 32322146 | We have expanded on non-US public health recommendations to provide guidance to frontline HCWs to enhance collaboration between clinicians, who are often siloed in their clinical practices, and ultimately to protect the federal workforce, which cannot sustain a significant loss of frontline HCWs. | 2020-04-26 |
| 32322398 | The limited clinical data about the virus’s behavior to date, especially extrapulmonary symptoms, suggest that we should be aware of the possibility of initial cerebrovascular manifestations of COVID-19. | 2020-04-26 |
| 32322400 | Most infected individuals are asymptomatic or only exhibit mild symptoms. […] After the incubation period, the most common symptoms are fever, cough and fatigue. | 2020-04-26 |
| 32322401 | However, in clinical trials, few broad-spectrum antiviral drugs were evaluated against COVID-19 infection which resulted in clinical recovery. | 2020-05-30 |
| 32322402 | Clinical trials are currently underway. | 2020-04-26 |
| 32322478 | No published treatment to date has been shown to adequately control the inflammation and respiratory symptoms associated with COVID-19, apart from oxygen therapy and assisted ventilation. […] Repeated use of both 2000 mg of PO and IV glutathione was effective in further relieving respiratory symptoms. | 2020-04-25 |
| 32322993 | In sum, SARS, MERS and COVID-19 are caused by recently discovered coronaviruses that cause flu-like illnesses, but with a clinical outcome that tends to be more severe. | 2020-05-01 |
| 32323646 | Although there are ongoing clinical trials of repurposed and investigational antiviral and immune-based therapies, there are as yet no scientifically proven, clinically effective pharmacological treatments for COVID-19. […] Among the repurposed drugs, the commonly used antimalarials chloroquine (CQ) and hydroxychloroquine (HCQ) have become the focus of global scientific, media, and political attention despite a lack of randomized clinical trials supporting their efficacy. | 2020-04-23 |
| 32323908 | Our history of agility in learning and teaching is now only inhibited by the time constraints of current clinical demands on the genetics community. | 2020-05-29 |
| 32323974 | The results of the validation experiment met the requirements for clinical diagnostic reagents. | 2020-05-21 |
| 32324209 | COVID-19 was confirmed by real-time reverse transcription-polymerase chain reaction and epidemiologic, clinical, radiologic, laboratory, and drug therapy data were analyzed in all patients. […] This study provides clinical data on the association between ACEIs/ARBs and outcomes in patients with hypertension hospitalized with COVID-19 infections, suggesting that ACEIs/ARBs are not associated with the severity or mortality of COVID-19 in such patients. | 2020-04-30 |
| 32324358 | The current article is a literature review, in which the authors elaborated the recently available scientific articles with their relevancy for clinical interventions as primary factor. | 2020-04-27 |
| 32324359 | We detail the relevant anamnestic factors and initial examination results which serve as basics for the clinical suspicion of COVID-19. | 2020-04-27 |
| 32324362 | This viral disease (COVID-19) can appear in a variety of forms, from asymptomatic through the spectrum of mild symptoms to severe respiratory failure, requiring intensive care. | 2020-04-27 |
| 32324456 | John Tingle, Lecturer in Law, Birmingham Law School, University of Birmingham, discusses some recent reports in maternity care, which can be seen to also to have general application across all clinical specialities. | 2020-04-27 |
| 32324622 | With regard to cardiac electrophysiology (EP) services, we discuss the “real-world” challenges and solutions that have been essential for efficient and successful (i) ramping down of standard clinical practice patterns and (ii) pivoting of workflow processes to meet the demands of this pandemic. […] The aims of these recommendations are to outline: (1) essential practical steps to approaching procedures, as well as outpatient and inpatient care of EP patients, with relevant examples, (2) successful strategies to minimize exposure risk to patients and clinical staff while also balancing resource utilization, (3) challenges related to redeployment and restructuring of clinical and support staff, and (4) considerations regarding continued collaboration with clinical and administrative colleagues in order to implement these changes. | 2020-04-30 |
| 32324640 | The COVID-19 pandemic is dominating the educational and clinical environments and is now the biggest disruptor in all aspects of life, not just medical education. | 2020-05-02 |
| 32324653 | Consultation with clinical colleagues at each institution is suggested to establish a consensus reporting approach. | 2020-05-30 |
| 32325129 | The adaptable change in IL-10 level might contribute to the relatively mild pneumonia symptoms in children with 2019-nCoV pneumonia and bacterial co-infection might be a risk factor of severe 2019-nCoV pneumonia. | 2020-05-06 |
| 32325167 | Most prevalent symptoms (n) were breathlessness (67), agitation (43), drowsiness (36), pain (23), and delirium (24). | 2020-05-11 |
| 32325252 | Epidemiological studies showed that elder patients were more susceptible to severe diseases, while children tend to have milder symptoms. | 2020-05-31 |
| 32325282 | To evaluate lung abnormalities on thin-section computed tomographic (CT) scans in patients with COVID-19 and correlate findings to duration of symptoms. […] In total, 348 CT scans in 112 patients were classified according to the time after the onset of the initial symptoms, namely stage-1 (0-4 days); stage-2 (5-9 days); stage-3 (10-14 days); stage-4 (15-21 days); stage-5 (22-28 days); and stage-6 (＞28 days). | 2020-05-15 |
| 32325383 | Using a web-based cross-sectional survey, we collected data from 7,236 self-selected volunteers assessed with demographic information, COVID-19 related knowledge, generalized anxiety disorder (GAD), depressive symptoms, and sleep quality. […] The overall prevalence of GAD, depressive symptoms, and sleep quality of the public were 35.1%, 20.1%, and 18.2%, respectively. […] Younger people reported a significantly higher prevalence of GAD and depressive symptoms than older people. | 2020-05-19 |
| 32325642 | To evaluate the viability of the assay, a comparison between the RT-LAMP and a commercial RT-qPCR assay was made using 56 clinical samples. | 2020-04-27 |
| 32325767 | While novel vaccines and drugs that target SARS-CoV-2 are under development, this review provides information on therapeutics which are under clinical trials or are proposed to antagonize SARS-CoV-2. […] Since several antiviral therapies can inhibit viral replication cycles or relieve symptoms, mechanisms unique to RNA viruses will be important for the clinical development of antivirals against SARS-CoV-2. | 2020-04-27 |
| 32326426 | We urge national agencies and authorities to start clinical trials to evaluate the preventive effects of βCD-Citrox therapeutic oral biofilm rinses in reducing the viral load of the infection and possibly disease progression. | 2020-05-23 |
| 32326509 | Technical and logistical issues arise when establishing such a non-standardized treatment into clinical practice with safety and proper governance. […] In this context, our manuscript describes a process of donor safety screening for FMT compiling clinical and biological examinations, questionnaires and interviews of donors. | 2020-04-24 |
| 32326943 | The novel coronavirus (SARS-CoV-2) is new to humans, and only limited scientific evidence is available to identify the impact of the disease COVID-19 on SRH, including clinical presentation and outcomes of the infection during pregnancy, or for persons with STI/HIV-related immunosuppression. […] Beyond the clinical scope of SRH, we should not neglect the impacts at the health system level and disruptions or interruptions in regular provision of SRH services, such as pre- and postnatal checks, safe abortion, contraception, HIV/AIDS and sexually transmitted infections. […] Therefore, there is an urgent need for the scientific community to generate sound clinical, epidemiological, and psycho-social behavioral links between COVID-19 and SRH and rights outcomes. | 2020-04-27 |
| 32327202 | Nine of the 26 showed clinical signs of kidney injury that included increased serum creatinine and/or new-onset proteinuria. | 2020-05-13 |
| 32327229 | The clinical information and chest CT images of 93 patients infected with 2019-nCov from multiple centres were reviewed. […] The CT and clinical appearances of COVID-19 are variable and reflect the severity of COVID-19 to some extent. | 2020-05-12 |
| 32327397 | Combinations of hydroxychloroquine (HCQ) and azithromycin have been promoted as treatments for COVID-19 based on small, uncontrolled clinical trials that have not assessed potential risks. | 2020-04-27 |
| 32327490 | The first was "How should we/clinicians modify our clinical care pathway for people with epilepsy during the COVID-19 pandemic? | 2020-04-24 |
| 32327757 | Data on the detailed clinical progression of COVID-19 in conjunction with epidemiological and virological characteristics are limited. […] Common symptoms at illness onset were cough (n = 8) and fever (n = 7). […] Patients had mild to moderately severe illness; seven were hospitalized and demonstrated clinical or laboratory signs of worsening during the second week of illness. | 2020-04-24 |
| 32327758 | The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org. | 2020-05-28 |
| 32327904 | The available reports suggest that gastrointestinal (GI) involvement in coronavirus disease 2019 (COVID-19) is common and in some cases the GI symptoms may precede the respiratory symptoms. […] Many of the medications used for treatment of COVID-19 can also be associated with GI symptoms or liver injury and can be included in the differential diagnosis in these patients. | 2020-04-27 |
| 32328367 | This review will introduce a general overview of coronavirus and describe the clinical features, evaluation, and treatment of COVID-19 patients. […] Furthermore, our review focuses on the most up-to-date clinical information for the effective management, prevention, and counseling of patients worldwide. | 2020-04-27 |
| 32328588 | A 67-year-old female presented with upper respiratory symptoms and was diagnosed with COVID-19. […] Clinical course was complicated by development of Takotsubo cardiomyopathy. […] She was treated with pericardiocentesis, colchicine, corticosteroids and hydroxychloroquine with improvement in symptoms. | 2020-04-24 |
| 32328595 | This paper is aimed at addressing the urgent need to develop a protocol that will address the operatory and clinical aspects of dental care during the Coronavirus disease 2019 (COVID-19) outbreak. […] The epidemiology, clinical signs and symptoms, and modes of transmission of COVID-19 are presented. […] This protocol is based on a detailed review of the existing English language literature as well on the logistic and clinical experience of each facility and the opinion of the authors. […] The first part of this review discusses operatory considerations; the second part discusses general dental clinical aspects; the third part discusses endodontic considerations; and the fourth part discusses surgical aspects. […] Logistic and clinical steps are required to provide dental care during the COVID-19 outbreak while preventing cross-contamination and protecting the dental team during the provision of care. | 2020-04-27 |
| 32328757 | Management of patients with retinal disease receiving intravitreal injections during the COVID-19 pandemic will require adjustment to regular clinical practice to minimize the risk of exposure of patients and healthcare staff, and to prioritize those with the greatest medical need. | 2020-05-21 |
| 32328954 | Clinical features of COVID-19 include high fever, cough, and fatigue which may progress to ARDS. […] The importance of a clinical pathway to implement the most effective and relevant diagnostic strategy is of critical importance to establish the control of this virus that is responsible for more and more deaths each day. | 2020-05-08 |
| 32329026 | Although this should be interpreted cautiously, it may be possible that either the viral clearance kinetics in these matrices matches the progressive clinical recovery of the patient or that the virus was never present in these fluids at the time of the laboratory diagnosis. | 2020-05-07 |
| 32329044 | Clinical and experimental studies have shown that the coronavirus family has a certain tropism for the central nervous system. […] Neurological symptoms have been reported in patients affected by COVID-19, such as headache, dizziness, myalgia and anosmia, as well as cases of encephalopathy, encephalitis, necrotising haemorrhagic encephalopathy, stroke, epileptic seizures, rhabdomyolysis and Guillain-Barre syndrome, associated with SARS-CoV-2 infection. | 2020-04-28 |
| 32329222 | Self-reported olfactory impairment has recently been recognized as a hallmark of Covid-19 and may be an important predictor of clinical outcome. […] A retrospective review of all patients presenting to a San Diego Hospital system with laboratory-confirmed positive Covid-19 infection was conducted with evaluation of olfactory and gustatory function and clinical disease course. […] Smell loss in Covid-19 may associate with a milder clinical course. | 2020-04-24 |
| 32329246 | In this review, we discuss the repurposing of fibrinolytic drugs, namely tissue-type plasminogen activator (tPA), to treat COVID-19 associated ARDS. tPA is an approved intravenous thrombolytic treatment, and the nebulizer form has been shown to be effective in plastic bronchitis and is currently in Phase II clinical trial. | 2020-04-24 |
| 32329275 | All articles were categorized into epidemiology, clinical diagnosis and treatment, basic research, pregnant women and children, mental health, epidemic prevention & control, and others. | 2020-04-27 |
| 32329419 | The clinical trials are underway for Remdesivir, an investigational anti-viral drug from Gilead Sciences. | 2020-05-14 |
| 32329520 | Where available, data from clinical trials involving patients with COVID-19 are reported. […] Preliminary clinical trials seem to support their benefit. […] Thus, adequate clinical trials are necessary for these compounds. […] Nevertheless, while waiting for effective preventive measures i.e. vaccines, many clinical trials on drugs belonging to different therapeutic classes are currently underway. […] Their results will help us in defining the best way to treat COVID-19 and reducing its symptoms and complications. | 2020-05-16 |
| 32329659 | In order to better control the rapid spread of coronavirus and manage the COVID-19 crisis, both developed and developing countries can improve the efficiency of their health system by replacing a proportion of face-to-face clinical encounters with telehealth. | 2020-04-24 |
| 32329756 | Highlighting the potential clinical relevance of these findings, cell-free DNA strongly correlated with acute phase reactants including C-reactive protein, D-dimer, and lactate dehydrogenase, as well as absolute neutrophil count. | 2020-05-29 |
| 32329877 | In this crisis, a collective pool of knowledge about the advancement of clinical diagnostic and management for COVID-19 is a prerequisite. […] Moreover, the review discusses different aspects of the COVID-19, including its epidemiology; incubation period; the general clinical features of patients; the clinical features of intensive care unit (ICU) patients; SARS-CoV-2 infection in the presence of co-morbid diseases and the clinical features of pediatric patients infected with the SARS-CoV-2. | 2020-04-30 |
| 32329915 | The coronavirus disease 2019 (COVID-19) affects principally the respiratory tract but recent studies described that COVID-19 could present a broader clinical spectrum from the absence of any symptoms to heart 1 , digestive 2 or Ear-Nose-Throat (including anosmia and ageusia) 3 manifestations. | 2020-04-24 |
| 32329920 | The coronavirus disease 2019 (COVID-19) pandemic has resulted in the reorganization of health-care settings affecting clinical care delivery to patients with Duchenne and Becker muscular dystrophy (DBMD) as well as other inherited muscular dystrophies. […] We address issues surrounding corticosteroid and exon-skipping treatments, cardiac medications, hydroxychloroquine use, emergency/respiratory care, rehabilitation management, and the conduct of clinical trials. | 2020-05-05 |
| 32329921 | The coronavirus disease 2019 (COVID-19) pandemic has resulted in reorganization of healthcare settings affecting the delivery of clinical care to patients with spinal muscular atrophy (SMA). […] There is a concern that patients with SMA may be at increased risk of manifesting severe symptoms of COVID-19. | 2020-05-06 |
| 32329922 | Articles reporting clinical practice guidelines for tracheostomy in the context of COVID-19 were included. | 2020-05-29 |
| 32329923 | Factors contributing to reduced clinical volume included lack of personal protective equipment (PPE) (35%) and lack of rapid COVID-19 testing (86%). | 2020-05-29 |
| 32329926 | This study is a multidisciplinary review of institutional tracheostomy guidelines and clinical pathways. […] Modifications to support clinical decision making in the context of COVID-19 were derived by consensus and available evidence. | 2020-05-29 |
| 32329971 | Symptoms that had been present during the preceding 14 days were recorded. […] Residents with SARS-CoV-2 infection were categorized as symptomatic with typical symptoms (fever, cough, or shortness of breath), symptomatic with only atypical symptoms, presymptomatic, or asymptomatic. […] Of these 48 residents, 27 (56%) were asymptomatic at the time of testing; 24 subsequently developed symptoms (median time to onset, 4 days). | 2020-05-29 |
| 32329978 | The aim of the study was to identify the clinical characteristics and risk factors associated with severe incidence of SARS ‑CoV‑2 infection. | 2020-05-29 |
| 32330073 | Despite some similarities in clinical features between the two entities, such as hypoxemia, radiographic opacities and altered lung compliance, the pathophysiological mechanisms of HAPE and lung injury due to COVID-19 are fundamentally different and the entities cannot be viewed as equivalent. | 2020-04-24 |
| 32330078 | Oral symptoms are prominent before fever and cough occur. | 2020-04-24 |
| 32330209 | The clinical features of the infection are not specific and are often indistinguishable from those of other respiratory infections, making it difficult to diagnose. | 2020-04-27 |
| 32330277 | This parallel, double-masked, randomized, phase IIb clinical trial with 81 adult patients who were hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was conducted from March 23 to April 5, 2020, at a tertiary care facility in Manaus, Brazilian Amazon. […] Secondary end points included participant clinical status, laboratory examinations, and electrocardiogram results. | 2020-04-29 |
| 32330287 | Clinical presentation and outcomes of COVID-19 infection during pregnancy remain limited and fragmented. […] To summarize the existing literature on COVID-19 infection during pregnancy and childbirth, particularly concerning clinical presentation and outcomes. […] A descriptive summary organized by aspects of clinical presentations (symptoms, imaging, and laboratory) and outcomes (maternal and perinatal). […] COVID-19 infection during pregnancy probably has a clinical presentation and severity resembling that in non-pregnant adults. | 2020-05-18 |
| 32330288 | Blood transfusion programmes should be continued, but specific changes to usual clinical pathways can be instituted to reduce risk of patient exposure to COVID-19, as well as contingency planning for possible reductions in blood available for transfusions. | 2020-05-19 |
| 32330293 | As an emerging infectious disease, the clinical course and virological course of SARS-CoV-2 infection remain to be further investigated. […] In this case report, we described a case of SARS-CoV-2 infection with clinical course more than two months. […] In conclusion, these findings indicate that SARS-CoV-2 can cause a long clinical course. | 2020-04-24 |
| 32330297 | It is best implemented in subgroups with low clinical suspicion. | 2020-05-03 |
| 32330303 | Clinical and laboratory data were collected and analyzed. | 2020-05-08 |
| 32330305 | The purpose of this study was to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ribonucleic acid (RNA) in urine and blood specimens, and anal and oropharyngeal swabs from patients with confirmed SARS-CoV-2 infection, and correlated positive results with clinical findings. […] Patients’ demographic and clinical data were recorded. […] The presence of viral RNA was not necessarily predictive of clinical symptoms, for example, the presence of viral RNA in the urine did not necessarily predict urinary tract symptoms. | 2020-05-05 |
| 32330313 | This study is to investigate the clinical characteristics of late pregnancy with asymptomatic 2019 novel coronavirus disease (COVID-19) infection, evaluate the outcome of maternal and fetal prognosis, and identify the evidence of intrauterine vertical transmission. […] Clinical data including laboratory test results and chest computed tomography (CT) scanning were collected and reviewed. […] We reported an asymptomatic COVID-19 pregnant woman with detailed clinical information and our result indicated that for late pregnant women with asymptomatic COVID-19 infection, there might be no intrauterine infection caused by vertical transmission. | 2020-04-30 |
| 32330317 | Given the cancellation of all elective procedures with the COVID-19 crisis, many anesthesiology learners are assigned to stay at home, limiting opportunities to learn in the clinical environment. | 2020-04-24 |
| 32330343 | Baseline characteristics, clinical presentation, antiviral and immunosuppressive management were compared between patients with mild/moderate and severe disease (defined as ICU admission, intubation or death). […] The most common presenting symptoms were fever (70%), cough (59%), and dyspnea (43%). | 2020-05-19 |
| 32330356 | With the rapidly expanding pandemic of SARS-CoV-2, there is concern that solid organ transplant recipients will be particularly vulnerable to infection and may experience a more severe clinical course. […] We describe each patient’s medical history including transplantation history, their clinical presentation and workup, and their course from diagnosis to either hospital discharge or to improvement in symptoms. […] These reports demonstrate a range of symptoms, clinical severity, and disease course in solid organ transplant recipients with COVID-19, including two hospitalized patients and two patients managed entirely in the outpatient setting. | 2020-05-08 |
| 32330458 | When a new infectious disease emerges, appropriate case definitions are important for clinical diagnosis and for public health surveillance. | 2020-05-13 |
| 32330521 | We also searched the largest clinical medicine preprint repository, medRxiv.org. […] The adequately powered, comparative, and robust clinical research that is needed for optimal evidence-informed decision-making remains absent in COVID-19. | 2020-05-08 |
| 32330544 | This document addresses the care of these patients focusing on 1) the varied clinical presentations; 2) appropriate personal protection equipment (PPE) for health care workers; 3) role of the Emergency Department, Emergency Medical System and the Cardiac Catheterization Laboratory; and 4) Regional STEMI systems of care. | 2020-05-03 |
| 32330593 | Since the declaration of the coronavirus 2019 (COVID-19) outbreak as pandemic, there are reports on the increased prevalence of physical symptoms observed in the general population. […] We investigated the association between psychological outcomes and physical symptoms among healthcare workers. […] The prevalence of physical symptoms displayed by healthcare workers and the associations between physical symptoms and psychological outcomes of depression, anxiety, stress, and post-traumatic stress disorder (PTSD) were evaluated. […] The commonest reported symptom was headache (32.3%), with a large number of participants (33.4%) reporting more than four symptoms. […] Participants who had experienced symptoms in the preceding month were more likely to be older, have pre-existing comorbidities and a positive screen for depression, anxiety, stress, and PTSD. […] After adjusting for age, gender and comorbidities, it was found that depression (OR 2.79, 95% CI 1.54-5.07, p = 0.001), anxiety (OR 2.18, 95% CI 1.36-3.48, p = 0.001), stress (OR 3.06, 95% CI 1.27-7.41, p = 0.13), and PTSD (OR 2.20, 95% CI 1.12-4.35, p = 0.023) remained significantly associated with the presence of physical symptoms experienced in the preceding month. […] Linear regression revealed that the presence of physical symptoms was associated with higher mean scores in the IES-R, DASS Anxiety, Stress and Depression subscales. […] Our study demonstrates a significant association between the prevalence of physical symptoms and psychological outcomes among healthcare workers during the COVID-19 outbreak. […] We postulate that this association may be bi-directional, and that timely psychological interventions for healthcare workers with physical symptoms should be considered once an infection has been excluded. | 2020-04-27 |
| 32331217 | In fact, the main clinical manifestation of COVID-19 patients is represented by an acute hypoxic respiratory failure secondary to bilateral pulmonary infiltrates, that in many cases, results in an acute respiratory distress syndrome and requires an invasive ventilator support. […] It can also limit the room contamination, improve comfort for the patients, and allow for better clinical assistance with long-term tolerability. | 2020-05-23 |
| 32331343 | In addition to this first aspect, the recent evidence of an increased frequency of venous thromboembolism in patients with COVID-19 (a clinical element associated with a worse prognosis) calls the attention on the safety of treatment with testosterone, in particular in hypogonadal men with greater genetic predisposition. | 2020-04-28 |
| 32331519 | We report here the clinical features and therapeutic course of the first reported patient with confirmed COVID-19 pneumonia that recovered in Colombia, after the use of chloroquine and clarithromycin. […] Progressively his clinical condition improved and at day 9, patient rRT-PCR for SARS-CoV-2 became negative. […] This and other COVID-19 cases are urgently demanding results from clinical trials that support evidence-based therapeutical approaches to this pandemic and the clinical management of patients, especially those at critical care. | 2020-04-28 |
| 32331845 | We discuss and propose mitigation strategies for: the risk of COVID-19 infection and its associated morbidity and mortality for individuals with ADRD; the impact of COVID-19 on the diagnosis and clinical management of ADRD; consequences of societal responses to COVID-19 in different ADRD care settings; the effect of COVID-19 on caregivers and physicians of individuals with ADRD; mental hygiene, trauma, and stigma in the time of COVID-19; and the potential impact of COVID-19 on ADRD research. | 2020-04-28 |
| 32332004 | Procedures that are particularly at high risk of contamination are clinical and flexible endoscopic pharyngo-laryngological evaluation, and probably also video fluoroscopic swallowing exams. | 2020-05-22 |
| 32332061 | Our objective was to evaluate three sample-to-answer molecular diagnostic platforms (Cepheid Xpert® Xpress SARS-CoV-2 [Xpert Xpress], Abbott ID NOW™ COVID-19 [ID NOW], GenMark ePlex® SARS-CoV-2 Test [ePlex]) to determine analytical sensitivity, clinical performance, and workflow for the detection of SARS-CoV-2 in nasopharyngeal swabs from 108 symptomatic patients. […] In the workflow analysis, the ID NOW produced the most rapid time to result per specimen (∼17 minutes) as compared to the Xpert Xpress (∼46 minutes) and the ePlex (∼1.5 hours), but what the ID NOW gained in rapid results, it lost in analytical and clinical performance. […] Information about the clinical and analytical performance of these assays, as well as workflow, will be critical in making informed and timely decisions on testing platform. | 2020-04-25 |
| 32332185 | This demanded an unprecedented adaptation of our hospital organisation, and we have met many clinical issues in the care for Covid-19 patients. | 2020-04-28 |
| 32332319 | Neurological symptoms and gastrointestinal symptoms were rare at onset in COVID-19. […] Here we report a 37-year-old man with vertigo, fever, and diarrhea symptoms as the first manifestation. […] We illustrate the symptoms initiation, the laboratory test results, the imaging examination, and the treatment strategy in the duration of COVID-19 with a timeline chart. | 2020-05-06 |
| 32332481 | After receiving reports of newly confirmed cases, an epidemiological services team at the CCDC or trained medical professionals at local clinical facilities start a case-contact investigation. | 2020-05-29 |
| 32333196 | As we know more about the clinical and laboratory features of COVID-19, which is now accepted as a pandemic, many questions have been raised about how to manage and monitor the treatment of cancer patients. | 2020-04-28 |
| 32333248 | The early warning indicators for severe pediatric cases have been summarized which is utmost important for clinical practice. | 2020-05-01 |
| 32333431 | There is a paucity of clinical data on critically ill patients with COVID-19 requiring extracorporeal life support. […] A statewide multi-institutional collaborative for COVID-19 patients was utilized to obtain clinical data on the first 10 critically ill COVID-19 patients who required extracorporeal membrane oxygenation (ECMO). […] The most common symptoms leading to the presentation were high fever ≥103°F (90%), cough (80%) and dyspnea (70%), followed by fatigue and gastrointestinal symptoms (both 30%), myalgia, loss of taste, pleuritic chest pain, and confusion (all 10%). […] These preliminary multi-institutional data from a statewide collaborative offer insight into the clinical characteristics of the first 10 patients requiring ECMO for COVID-19 and their initial clinical course. | 2020-04-25 |
| 32333487 | Clinical heterogeneity potentially driven by differential host immune-mediated responses will require extensive investigation. | 2020-05-23 |
| 32333603 | Healthcare worker contacts of an initially undiagnosed COVID-19 case, who were without personal protective equipment, in particular not wearing facemasks, were screened with nasopharyngeal swabs and polymerase chain reaction tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), irrespective of respiratory symptoms or fever seven days after initial contact. […] Three healthcare workers reported respiratory symptoms (cough) or low-grade fever within 4 days. […] All 21 healthcare workers tested SARS-CoV-2 negative 7 days after initial index case contact, including the three healthcare workers with previous symptoms. | 2020-04-29 |
| 32333832 | The worldwide medical community is striving to pursue the most appropriate clinical choices in the worst event of pandemic of the modern times [1], with over 1 million patients affected by COVID-19 (i.e., swab positive patients with or without symptoms) reported so far [1]. | 2020-04-25 |
| 32333836 | Here, we show that clinical grade hrsACE2 reduced SARS-CoV-2 recovery from Vero cells by a factor of 1,000-5,000. | 2020-05-19 |
| 32333849 | In this context, however, there has been little clinical guidance or information regarding life-threatening conditions requiring emergency surgery that cannot be delayed. […] We herein present a case of acute type A aortic dissection with COVID-19 in order to highlight the clinical implications of a true emergent procedure during the COVID-19 outbreak. | 2020-04-27 |
| 32333961 | We provide a toolbox of strategies for supporting family-centered inpatient care during physical distancing responsive to the current clinical climate. | 2020-05-13 |
| 32334062 | Numerous potential therapies, including supportive intervention, immunomodulatory agents, antiviral therapy, and convalescent plasma transfusion, have been tentatively applied in clinical settings. […] Furthermore, intensive research and clinical trials are underway to assess the efficacy of existing drugs and identify potential therapeutic targets to develop new drugs for treating COVID-19. | 2020-04-29 |
| 32334064 | The COVID-19 pandemic has led to high levels of psychological distress in the general public, including symptoms of anxiety and depression. […] It was found that many of the measures advocated in their guidelines could positively influence immunity either by direct effects on symptoms of depression or anxiety, or through their symbolic significance. | 2020-04-28 |
| 32334082 | Combined with clinical data, we showed that pancreatic injury can occur in some COVID-19 patients. | 2020-05-23 |
| 32334118 | To explore the clinical value of immune-inflammatory markers to assess the severity of coronavirus disease 2019 (COVID-19). 127 consecutive hospitalized patients with confirmed COVID-19 were enrolled in this study, and classified into non-severe and severe groups. […] Demographics, symptoms, underlying diseases and laboratory data were collected and assessed for predictive value. | 2020-05-29 |
| 32334163 | The symptoms are fever, malaise, and cough which resolve in a few days in most cases; but may progress to respiratory distress and organ failure. | 2020-05-19 |
| 32334392 | While data regarding nutrition in coronavirus infection (COVID-19) are not available, in this review, we aimed to evaluate evidence from previous clinical trials that studied nutrition-based interventions for viral diseases (with special emphasis on respiratory infections), and summarise our observations. […] Clinical trials on vitamins, minerals, nutraceuticals and probiotics were included. | 2020-05-27 |
| 32334862 | In order to better address this major health crisis, which has given rise to numerous scientific publications, we have synthesized the main original clinical studies to facilitate the day-to-day management of patients with COVID-19. […] We detail the early signs and progression of the disease as well as the different clinical forms, including extra-pulmonary, as known at the beginning of this pandemic. […] We focus on clinical, biological and CT markers predictive of severity or mortality. | 2020-05-08 |
| 32334905 | Despite most of patients develops benign symptoms, cancer patients are at risk of a severe form of the disease. | 2020-04-28 |
| 32335053 | To evaluate the clinical characteristics and outcomes in pregnancy and the vertical transmission potential of severe acute respiratory syndrome coronavirus 2 infection. […] Clinical records were retrospectively reviewed for 116 pregnant women with coronavirus disease 2019 pneumonia from 25 hospitals in China between January 20, 2020, and March 24, 2020. […] The most common symptoms were fever (50.9%, 59/116) and cough (28.4%, 33/116); 23.3% (27/116) patients presented without symptoms. | 2020-05-26 |
| 32335067 | The panel was convened by video teleconference to discuss and then vote on statements related to 12 common clinical scenarios. […] Twelve statements related to baseline and annual lung cancer screening (n = 2), surveillance of a previously detected lung nodule (n = 5), evaluation of intermediate and high-risk lung nodules (n = 4), and management of clinical stage I non-small cell lung cancer (n = 1) were developed and modified. | 2020-05-24 |
| 32335068 | Further studies are needed to confirm our observed clinical efficacy. | 2020-05-05 |
| 32335089 | The detection of SARS-CoV-2 RNA by real-time reverse transcription-polymerase chain reaction (rRT-PCR) is used to confirm the clinical diagnosis of COVID-19 by molecular diagnostic laboratories. […] The proposed multiplex rRT-PCR methodology will enable highly sensitive detection of SARS-CoV-2 RNA, reducing reagent use and cost, and time required by clinical laboratory technicians. | 2020-05-18 |
| 32335167 | Patients presenting with respiratory symptoms at outpatient clinics or hospital wards were screened for COVID-19 per protocol. […] Community-wide mask wearing may contribute to the control of COVID-19 by reducing the amount of emission of infected saliva and respiratory droplets from individuals with subclinical or mild COVID-19. | 2020-05-04 |
| 32335169 | We aimed to find risk factors for the progression of COVID-19 to help reducing the risk of critical illness and death for clinical help. […] Clinical manifestations such as fever, shortness of breath or dyspnea were associated with the progression of disease [fever: 0R = 0.56, 95% CI (0.38, 0.82), P = 0.003;shortness of breath or dyspnea: 0R=4.16, 95% CI (3.13, 5.53), P < 0.00001]. […] Laboratory examination such as aspartate amino transferase(AST) > 40U/L, creatinine(Cr) ≥ 133mol/L, hypersensitive cardiac troponin I(hs-cTnI) > 28pg/mL, procalcitonin(PCT) > 0.5ng/mL, lactatede hydrogenase(LDH) > 245U/L, and D-dimer > 0.5mg/L predicted the deterioration of disease while white blood cells(WBC)<4 × 109/L meant a better clinical status[AST > 40U/L:OR=4.00, 95% CI (2.46, 6.52), P < 0.00001; Cr ≥ 133μmol/L: OR = 5.30, 95% CI (2.19, 12.83), P = 0.0002; hs-cTnI > 28 pg/mL: OR = 43.24, 95% CI (9.92, 188.49), P < 0.00001; PCT > 0.5 ng/mL: OR = 43.24, 95% CI (9.92, 188.49), P < 0.00001;LDH > 245U/L: OR = 43.24, 95% CI (9.92, 188.49), P < 0.00001; D-dimer > 0.5mg/L: OR = 43.24, 95% CI (9.92, 188.49), P < 0.00001; WBC < 4 × 109/L: OR = 0.30, 95% CI (0.17, 0.51), P < 0.00001]. […] Clinical manifestation such as fever, shortness of breath or dyspnea and laboratory examination such as WBC, AST, Cr, PCT, LDH, hs-cTnI and D-dimer could imply the progression of COVID-19. | 2020-05-03 |
| 32335171 | We present the epidemiological and clinical features of the clusters of three large and one small families. […] Among those infected, 20/22 had mild symptoms and only two had moderate to severe clinical manifestations. […] Children in the families generally showed milder symptoms. | 2020-05-03 |
| 32335200 | There were no significant differences in the severity of psychiatric symptoms between workers/technicians and executives/managers. >95% reported psychoneuroimmunity prevention measures including good ventilation in the workplace and wore a face mask as protective. […] Factors that were associated with the severity of psychiatric symptoms in the workforce were marital status, presence of physical symptom, poor physical health and viewing return to work as a health hazard (p < 0.05). […] In contrast, personal psychoneuroimmunity prevention measures including hand hygiene and wearing face masks as well as organizational measures including significant improvement of workplace hygiene and concerns from the company were associated with less severe psychiatric symptoms (p < 0.05). […] Contrary to expectations, returning to work had not caused a high level of psychiatric symptoms in the workforce. […] The low prevalence of psychiatric symptoms could be due to confidence instilled by psychoneuroimmunity prevention measures before the resumption of work. | 2020-04-29 |
| 32335334 | Considering the current pandemic of COVID-19, it is imperative to gauge the role of molecular divergence in SARS-CoV-2 with time, due to clinical and epidemiological concerns. […] We believe that such molecular analyses correlated with clinical characteristics and host predisposition need to be evaluated at the earliest to understand viral adaptability, disease prognosis, and transmission dynamics. | 2020-05-29 |
| 32335336 | Vaccines targeting women of reproductive age, and in particular pregnant patients, should be evaluated in clinical trials and should include the endpoints of neonatal infection and disease. | 2020-05-27 |
| 32335338 | This study aims to evaluate the clinical characteristics and outcomes of pregnant women confirmed with COVID-19 to provide reference for clinical work. […] The clinical features and outcomes of 10 pregnant women confirmed with COVID-19 at Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, a tertiary- care teaching hospital in Hubei province, Wuhan, China from January 23 to February 23, 2020 were retrospectively analyzed. | 2020-05-29 |
| 32335456 | Our hypothesis needs to be tested in in vitro and clinical studies, however as we are in an urgent situation as the burden of SARS-CoV2 is increasing all around the world, we recommend the usage of unfractioned heparin or LMWH in intensive care unit (ICU) and non-ICU hospitalized patients with the risk-benefit judgement of the clinician. | 2020-05-26 |
| 32335560 | We seek to draw the attention of the scientific community to the possibility of drastically reducing the effects of the virus on the affected patients and improving clinical trials outcome through the synergistic action of zinc and chloroquine in patients suffering from the coronavirus disease. | 2020-04-28 |
| 32335561 | At the same time, a great number of clinical trials have been launched to investigate the potential efficacy therapies for COVID-19 highlighting the urgent need to get as quickly as possible high-quality evidence. | 2020-04-28 |
| 32335585 | CoV, and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) with its clinical presentations. […] There is no proven antiviral agent against SARS-CoV-2 so the treatment for COVID-19 is symptomatic, aiming for the management of the symptoms and prevention of the complications. | 2020-04-28 |
| 32335609 | The novel coronavirus (COVID-19) cause various symptoms such as pneumonia, fever, breathing difficult and lung infection. […] This case series is to describe the initial clinical features of COVID-19 among the patients admitted in isolation ward of Seti Provincial Hospital. […] The patient coming from United Arab Emirate was presented with mild symptoms and others were asymptomatic. | 2020-04-29 |
| 32335697 | This article aims to share northern Italy’s experience in hospital re-organization and management of clinical pathways for traumatic and orthopaedic patients in the early stages of the COVID-19 pandemic. | 2020-05-29 |
| 32335900 | The current international COVID-19 health crisis underlines the importance of adequate and suitable personal protective equipment for clinical staff during acute airway management. | 2020-05-29 |
| 32336042 | We evaluated ocular symptoms and ocular tropism of SARS-CoV-2 in a group of patients with COVID-19. […] Ocular history and ocular symptoms data were obtained by communicating directly with the subjects. […] Fifteen (27%) had aggravated ocular symptoms, of which 6 (11%) had prodromal ocular symptoms before disease onset. […] Ocular symptoms are relatively common in COVID-19 disease and may appear just before the onset of respiratory symptoms. | 2020-04-26 |
| 32336069 | The most common symptoms of COVID‑19 are: fever (81.8%-100%), cough (46.3%-86.2%), myalgia and fatigue (11%-50%), expectoration (4.4%-72%), and dyspnea (18.6%-59%). […] One of the life‑threatening cardiac manifestations is coronavirus fulminant myocarditis, which may also occur without accompanying symptoms of pulmonary involvement. […] Thus, it is important to know typical COVID‑19 symptoms, possible clinical manifestations, complications, and recommended treatment. | 2020-04-30 |
| 32336243 | Through a comprehensive review of existing studies on COVID-19, this article presents the epidemiological and clinical characteristics of COVID-19, reviews current medical management, and suggests ways to improve the safety of anesthetic procedures. | 2020-05-14 |
| 32336519 | We report the summarized findings of these studies, the financial and HIPAA considerations of using telemedicine, potential benefits, pitfalls and strategies for the utilization of telemedicine into the clinical practice of general surgery and its subspecialties during the COVID-19 pandemic. | 2020-05-05 |
| 32336563 | This consensus document has been prepared on evidence-informed guidelines developed by a multidisciplinary panel of health care providers from four Spanish scientific societies (Spanish Society of Intensive Care Medicine [SEMICYUC], Spanish Society of Pulmonologists [SEPAR], Spanish Society of Emergency [SEMES], Spanish Society of Anesthesiology, Reanimation, and Pain [SEDAR]) with experience in the clinical management of patients with COVID-19 and other viral infections, including SARS, as well as sepsis and ARDS. […] The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. | 2020-04-27 |
| 32336572 | In this paper, we have presented an adult otitis media case whom infected with COVID-19, but she have not any classical COVID-19 symptoms. | 2020-04-30 |
| 32336586 | PubMed and SCOPUS were queried using a combination of the keywords “COVID 19,” “SARS-CoV-2,” and “treatment.” All types of studies were evaluated including systematic reviews, case-studies, and clinical guidelines. […] There are several ongoing clinical trials that are testing the efficacy of single and combination treatments with the drugs mentioned in this review and new agents are under development. | 2020-05-03 |
| 32336594 | Clinical data from hospitals in China have revealed that approximately 10% of the infected patients have severe disease requiring intensive care. | 2020-04-30 |
| 32336612 | Clinical reports of patients infected with SARS-CoV-2 show that several features associated with infection and severity of the disease (i.e., older age, hypertension, diabetes, cardiovascular disease) share a variable degree of ACE2 deficiency. | 2020-04-30 |
| 32336723 | Currently, no treatment for SARS-CoV-2 are approved because of lack of evidence, but a number of clinical trials are in process and we are expecting fruitful results very soon. […] This review focuses on various approaches of treatment and few of the most recent clinical trials carried out in this field. | 2020-05-08 |
| 32336959 | Due to lack of data on treatment strategies specific to this subset of patients, currently available evidence on management of the critically ill needs to be extrapolated and customized to their clinical needs. […] The article calls attention to fluid stewardship in the critically ill with COVID-19 by judiciously applying the evidence-based resuscitation principles to their specific clinical features such as high rates of cardiac injury. | 2020-05-06 |
| 32337113 | In this study, we will provide a brief review of viral origin, identification, symptoms, transmission, diagnosis, and potential treatment strategies for the newly identified SARS-CoV-2 strain. | 2020-04-30 |
| 32337131 | However, the unpreparedness of the nations, even with the advanced medical sciences and resources, has failed to address the mental health aspect amongst the public, as all efforts are focused on understanding the epidemiology, clinical features, transmission patterns, and management of COVID-19 pneumonia. | 2020-04-30 |
| 32337143 | The disease is characterized by distinct medical signs and symptoms that include high fever, chills, cough, and shortness of breath or difficulty in breathing. […] The infected people may also present with other symptoms such as diarrhea, myalgia, fatigue, expectoration, and hemoptysis. | 2020-04-30 |
| 32337148 | Patients with Covid-19 disease commonly present with symptoms related to respiratory illness, and less commonly they develop cardiovascular complications either on presentation or during the course of the disease. | 2020-04-30 |
| 32337151 | Thus, COVID-19, due to its regular flu-like symptoms, is also expected to show similar seasonality and subside as the global temperatures rise in the northern hemisphere with the onset of spring. | 2020-04-30 |
| 32337201 | The symptoms included fever, coughing, and breathing difficulties. […] A few patients with this infection may only have atypical symptoms, which could lead to a misdiagnosis and subsequently further facilitate the spread of the virus. […] Given the clinical characteristics, epidemiological history, and examination, the patient was diagnosed with coronavirus disease-2019 (COVID-19). […] Our patient had atypical symptoms of COVID-19. | 2020-04-30 |
| 32337584 | In addition, each contact was assessed for exposure to the index case and monitored for clinical symptoms. […] Eleven cases reported flu-like symptoms without positive results. […] Ct values were significantly lower in cases presenting typical COVID-19 symptoms, suggesting high viral shedding (p =0.007). | 2020-05-06 |
| 32337591 | Clinical information and laboratory data were retrieved from electronic medical records. | 2020-05-06 |
| 32337664 | Tocilizumab, which is the IL-6 receptor antagonist, has been approved by the US FDA for the treatment of cytokine release syndrome (CRS), is expected to treat cytokine storm caused by COVID-19 and is now in clinical trials. […] In this paper, we will elaborate the role of cytokine storm in COVID-19, the mechanism of tocilizumab on cytokine storm and the key points of pharmaceutical care based on the actual clinical application for COVID-19 in our hospital, the latest research reports, clinical trial progress of tocilizumab, drug instruction from the US FDA, and “Diagnosis and Treatment Plan of Novel Coronavirus Pneumonia (seventh trial edition)” in China, so as to provide reference for the treatment of COVID-19. | 2020-05-28 |
| 32337769 | Therefore, any treatment which can decrease the severe symptoms due to lung damage may help attenuate mortality rates. | 2020-04-27 |
| 32337790 | The clinical course was complicated by extreme overexposure to the mammalian target of rapamycin inhibitor everolimus, following coadministration of chloroquine and lopinavir/ritonavir therapy. | 2020-05-13 |
| 32337859 | Herein, we demonstrated two distinct cases with different clinical progress. […] He was diagnosed with COVID-19 expressing relevant symptoms. […] The second case was developed in a 56-year-old man without any symptoms. […] These apparently different cases suggest that assertive screening and management could improve the clinical course. | 2020-05-16 |
| 32338155 | Anti-malarial medicine chloroquine (CQ) and particularly its chemical analogue hydroxychloroquine (HCQ) have been recommended as promising candidate therapeutics that are now under either compassionate off-label use or clinical trials for the treatment of COVID-19 patients. […] Given the fact that for decades HCQ has been approved as an immunomodulatory drug for the long term treatment of chronic rheumatic diseases, as experienced rheumatologists, we would like to share our thoughts in this regard and trigger a brainstorm among clinical care providers for exchanging their diverse opinions on this urgent topic. | 2020-05-05 |
| 32338224 | In this connection, both SARS-CoV and MERS-CoV have been shown to induce T cell apoptosis, thus, aggravating the clinical course of disease [24, 25]. […] Despite lymphopenia, evidence for an exaggerate release of proinflammatory cytokines [interleukin (IL)-1 and IL-6] has been reported in the course acute respiratory syndrome in COVID19 infected patients, thus, aggravating the clinical course of disease [34]. […] Then, Gurwitz suggests to evaluate severity of symptoms in COVID-19 infected patients under previous chronic treatment with AT1R blockers in comparison to COVID-19 infected patients who did not take AT1R blockers [40]. […] Conversely, increase in ACE2 expression may facilitate the access into the host of COVID-19, thus, aggravating the clinical picture. […] Such a dilemma would be solved by clinical trials based on RAS blockade or initiation and monitoring related effects. | 2020-04-27 |
| 32338254 | The clinical manifestations of Covid-19 range from asymptomatic carrier status to severe pneumonia. […] In a study of 7,736 Covid-19 patients in China, of all the clinical symptoms, hyposmia was not reported in any patient(2). | 2020-04-27 |
| 32338347 | Clinical symptoms are similar to any acute respiratory viral infection with less pronounced nasal symptoms. | 2020-05-19 |
| 32338400 | The COVID-19 pandemic has forced an abrupt change in the delivery of clinical services, including for individuals with an eating disorder. […] Articles included describe original research or systematic reviews on obstacles to health services use and strategies to improve access to care; technological tools to provide or enhance interventions; patients’ and clinicians’ attitudes or perspectives on using digital tools for clinical care; factors influencing therapeutic alliance; and ideas for improving reach and uptake of digital interventions. | 2020-05-15 |
| 32338566 | A literature review revealed few reports providing front-line clinical and research teams guidance related to multilevel, rapidly evolving COVID-19 directives.Method: The Rapid Assessment Procedure Informed Clinical Ethnography (RAPICE) method was used to develop a clinical case series and conduct participant observation during an ongoing comparative effectiveness trial of peer-integrated, patient-centered interventions after traumatic injury. […] Participants were patients enrolled in the intervention arm of the ongoing trial, as well as front-line clinicians, patient peer interventionists, and clinical research team members implementing the trial. […] A daily clinical research team huddle that flexibly accommodated virtual participation was also feasibly implemented.Conclusions: Primary and secondary COVID-19 prevention strategies can be feasibly integrated into ongoing clinical interventions during the pandemic. […] Routine, proactive clinical and research team communication that transparently addresses ethical tensions and health-sustaining activities may promote well-being for providers grappling with rapidly evolving pandemic directives. | 2020-04-27 |
| 32338605 | Common symptoms include a fever and persistent cough and COVID-19 patients also often experience an excess of fluid in the lungs, which makes it difficult to breathe. | 2020-05-14 |
| 32338613 | The top five searches related to health were “face masks,” “amuchina” (disinfectant), “symptoms of the novel coronavirus,” “health bulletin,” and “vaccines for coronavirus.” The regions of Umbria and Basilicata recorded a high number of infodemic monikers (APC weighted total >140). […] The majority of searches were related to amuchina, face masks, health bulletins, and COVID-19 symptoms. | 2020-05-08 |
| 32338767 | To slow the spread of COVID-19, both the paid and unpaid activities of these employees warrant consideration in the identification of appropriate clinical, policy, and informal supports. | 2020-05-14 |
| 32339074 | The novel coronavirus SARS-CoV-2 (COVID-19) strain has caused a pandemic that affects everyday clinical practice. | 2020-05-13 |
| 32339082 | The system is meant to be used in patients presenting with moderate to severe symptoms of COVID-19. […] The system was evaluated using 105 chest CTs of patients admitted to the hospital with clinical suspicion of COVID-19 in whom RT-PCR was performed (62 +/- 16 years, 61 men, 53 with positive RT-PCR). […] The resulting area under the receiver operating characteristics curve (AUC) was compared to results from RT-PCR and clinical diagnosis of COVID-19. […] The average AUC was 0.91 (95% CI 0.85-0.97) for predicting RT-PCR outcome and 0.95 (95% CI 0.91-0.99) for clinical diagnosis. […] Conclusions CO-RADS is a categorical assessment scheme for pulmonary involvement of COVID-19 on non-enhanced chest CT providing very good performance for predicting COVID-19 in patients with moderate to severe symptoms and has a substantial interobserver agreement, especially for categories 1 and 5. | 2020-04-27 |
| 32339091 | Meanwhile, nationwide surveillance data revealed drastic decreases in influenza diagnoses in outpatient departments, positivity rates of clinical specimens, and confirmed severe cases during the first 12 weeks of 2020 compared with the same period of 2019. | 2020-04-27 |
| 32339235 | Incorporation of COVID-19-associated risk models into analysis of randomized trials can help guide clinical decisions during this pandemic. | 2020-05-06 |
| 32339248 | This parallel, double-masked, randomized, phase IIb clinical trial with 81 adult patients who were hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was conducted from March 23 to April 5, 2020, at a tertiary care facility in Manaus, Brazilian Amazon. […] Secondary end points included participant clinical status, laboratory examinations, and electrocardiogram results. | 2020-04-30 |
| 32339250 | Many established medications have been used to treat the disease symptoms; however, no specific drugs or vaccines have been developed. | 2020-04-27 |
| 32339344 | Usual clinical manifestations of COVID-19 infection include fever, fatigue, myalgia, headache, diarrhea, dry cough, dyspnea that may lead to acute respiratory distress syndrome and death (1). […] Skin symptoms of COVID-19 have been poorly described but may include erythematous rash, urticaria and chicken pox like lesions (2-7). | 2020-04-27 |
| 32339382 | Data were collected from the clinical records using a standardised questionnaire on maternal general characteristics, any medical or obstetric co-morbidity, course of pregnancy, clinical signs and symptoms, treatment of COVID 19 infection, mode of delivery, neonatal data and breastfeeding. | 2020-05-29 |
| 32339391 | To reduce the severity and mortality with COVID-19, we propose to probe for the clinical response to thiazolidinediones (TZDs), PPARγ agonists, that are the well-known anti-diabetic drugs. | 2020-05-27 |
| 32339394 | With the COVID-19 pandemic, clinicians and researchers have been suddenly confronted with the difficulty of treatment provision and continuation of clinical trials without face-to-face contact. […] In this piece, we will describe electronic scales (e-scales) and provide guidance on how clinicians/researchers might best implement e-scales in their clinical practice or research studies to remotely measure weight. | 2020-04-27 |
| 32339508 | None of health care providers have developed symptoms or tested positive for COVID-19. | 2020-05-04 |
| 32339895 | Several sociodemographic variables like gender, profession, age, place of work, department of work and psychological variables like poor social support, self-efficacy were associated with increased stress, anxiety, depressive symptoms, insomnia in HCW. | 2020-05-30 |
| 32339960 | This study focused on older patients with COVID-19 infection and analyzed the epidemiological and clinical characteristics of them. […] The information including demographic, epidemiological, clinical, classification of severity and outcomes. […] 56.7 % of elderly confirmed patients were male, fever (78.3 %), cough (56.7 %), dyspnea (30.0 %), and fatigue (23.3 %) were common symptoms of COVID-19 infection. | 2020-05-29 |
| 32339971 | This protocol is a collaborative effort based on knowledge gleaned from clinical and simulation experience from Children’s Hospital Colorado, Children’s Hospital of Philadelphia, The Hospital for Sick Children in Toronto, and Boston Children’s Hospital. | 2020-05-19 |
| 32339998 | From the adoption of electronic medical records to mobile health apps and other disruptive technologies, digital health solutions have promised a better quality of care at a more sustainable cost. | 2020-05-07 |
| 32340018 | The patient’s symptoms and lung imaging changes were atypical. | 2020-04-27 |
| 32340047 | Across 13 identified studies, quarantine measures were consistently associated with negative psychosocial outcomes, including depressive symptoms, anxiety, anger, stress, posttraumatic stress, social isolation, loneliness and stigmatization. | 2020-04-29 |
| 32340048 | An extensive strain was reported due to stress experience as well as depression and anxiety symptoms. […] Severe degrees of those symptoms were found in 2.2 % to 14.5 % of all participants. […] The severity of mental symptoms was influenced by age, gender, occupation, specialization, type of activities performed and proximity to COVID-19 patients. […] Considering the frequency of mental symptoms occurring in healthcare workers, accompanying mental health informed interventions to facilitate coping are necessary. | 2020-04-29 |
| 32340051 | The SARS-CoV-2 pandemic triggered increasing symptoms of an undiagnosed delusional disorder at a mid-60-year-old woman resulting in an attempted suicide. […] Because of a pandemic with noticeable and visible social changes, it seems likely that people with previously subclinical psychotic illnesses are more often admitted to psychiatric care for the first time. | 2020-04-29 |
| 32340089 | Cough, fever, malaise and dyspnea were the main clinical symptoms. | 2020-04-28 |
| 32340092 | Based on systematic review of the role of clinical treatment, disease control and scientific research, and combining with the problems exposed by the COVID-19 epidemic, suggestions were proposed to reform and improve the prevention and treatment system for major epidemics diseases in China. […] In clinical treatment, it is necessary to enhance clinical staff’s awareness of law-based reporting, capabilities of syndromic surveillance, the use of infectious diseases reporting systems, and to improve national or local monitoring platforms for emerging infectious diseases detection. | 2020-04-28 |
| 32340095 | Objective: To analyze the clinical courses and outcomes of COVID-19 cases and the influencing factors in Guangdong province and provide basis for the formulation or adjustment of medical care and epidemic control strategy for COVID-19. Methods: We collected demographic data, medical histories, clinical courses and outcomes of 1 350 COVID-19 patients reported in Guangdong as of 4 March 2020 via epidemiological investigation and process tracking. […] Disease severity and clinical course characteristics of the patients and influencing factors of severe illness were analyzed in our study. Results: Among 1 350 cases of COVID-19 cases in Guangdong, 72 (5.3%) and 1049 (77.7%) were mild and ordinary cases, 164 (12.1%) were severe cases, 58 (4.3%) were critical cases and 7 (0.5%) were fatal. […] The influencing factors for severe illness or worse included male (aHR=1.87, 95%CI: 1.43-2.46), older age (aHR=1.67, 95%CI: 1.51-1.85), seeking medical care on day 2-3 after onset (aHR=1.73, 95%CI: 1.20-2.50) pre-existing diabetes (aHR=1.75, 95%CI: 1.12-2.73) and hypertension (aHR=1.49, 95%CI: 1.06-2.09). Conclusions: The course of illness and length of hospitalization of COVID-19 cases were generally long and associated with severity of disease clinical outcomes. | 2020-04-28 |
| 32340096 | Objective: To explore the feasibility of direct renin inhibitor aliskiren for the treatment of severe patients of COVID-19 with hypertension. Methods: A retrospective case analysis of effectiveness and safety of aliskiren treatment to lower blood pressure in three severe and one critically ill patients of COVID-19 with hypertension. Results: Four patients, two males and two females, with an average age of 78 years (66-87 years), were referred to hospital mainly because of respiratory symptoms. […] The condition improved, and all patients had reached the discharge standard and were discharged. Conclusion: Our preliminary clinical data shows that aliskiren’s antihypertensive therapy is effective and safe for severe COVID-19 patients complicated with hypertension. […] Further clinical aliskiren therapy study is required with more COVID-19 patients.. 目的： 探索直接肾素抑制剂阿利吉伦用于重型新型冠状病毒肺炎(COVID-19)合并高血压患者治疗的可行性。 | 2020-04-28 |
| 32340097 | We compared the epidemiological and clinical characteristics of severe acute respiratory syndrome (SARS), pandemic (H1N1) 2009 and COVID-19 and found that COVID-19 was more contagious, more concealed in transmission, with greater infectious intensity and more severe clinical manifestations. | 2020-04-28 |
| 32340216 | A wealth of mechanistic and clinical data show that vitamins, including vitamins A, B6, B12, C, D, E, and folate; trace elements, including zinc, iron, selenium, magnesium, and copper; and the omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid play important and complementary roles in supporting the immune system. | 2020-04-30 |
| 32340539 | The pandemic has resulted in significant changes in clinical practice for otolaryngologists in the United States; many changes have been implemented to mitigate risks identified by otolaryngologists in other countries. […] As a result of COVID-19 recommendations, multiple institutions have overhauled resident clinical rotations and resident education. | 2020-04-28 |
| 32340588 | Clinical data were derived from peer-reviewed primary literature and published guidelines from national or international medical organizations. | 2020-04-28 |
| 32340614 | Second, when necessary, CMR on patients with confirmed or suspected active COVID-19 should focus on the specific clinical question with an emphasis on myocardial function and tissue characterization while optimizing patient and staff safety. | 2020-04-30 |
| 32340654 | Issues include pharmacy practice, clinical therapeutics, and possible new treatments for the virus. | 2020-04-30 |
| 32340737 | In August 2014, our team developed and implemented an algorithm to triage suspected cases of Ebola virus disease in a midwestern United States emergency department and outpatient clinics based on patient travel history and symptoms. | 2020-04-30 |
| 32341078 | With the surge in COVID-19 cases worldwide, the medical community should be aware of atypical clinical presentations to help with correct diagnosis, to take the proper measures to place the patient in isolation and to avoid healthcare professionals being infected by coronavirus (SARS-CoV-2). […] To report that patients who subsequently test positive for COVID-19 may present with acute abdominal pain and no pulmonary symptoms, although they already have typical lung lesions on computed tomography (CT) scan. | 2020-04-28 |
| 32341103 | While relevant preclinical, experimental models to date favor a protective effect of RAAS-SCoV-axis inhibition on both lung injury and survival, clinical data related to the role of RAAS modulation in the setting of SARS-CoV-2 remains limited. […] We propose a preponderance of evidence that supports clinical equipoise regarding the efficacy of RAAS-based interventions, and the imminent need for a multisite randomised controlled clinical trial to evaluate the inhibition of the RAAS-SCoV-axis on acute lung injury in COVID-19. | 2020-05-01 |
| 32341111 | Patients with COVID-19 present a broad spectrum of clinical presentation. […] Identifying these clinical phenotypes and applying a personalised approach would benefit the optimisation of therapies and improve outcomes. | 2020-05-27 |
| 32341142 | This assay is the first rapid multiplex PCR (mPCR) assay including SARS-CoV-2 detection, and is fully compatible with a non-PCR trained laboratory or point-of-care (POC) testing.This evaluation was performed using 69 primary clinical samples (66 NPS, 1 BAL and 1 tracheal aspirate and 1 bronchial aspirate) comparing the SARS-CoV-2 detection with the currently WHO recommended RT-PCR (WHO-PCR) workflow. […] Additionally, a comparative limit of detection (LoD) assessment was performed between QIAstat-SARS and the WHO-PCR using a quantified clinical sample. […] The overall percent agreement between QIAstat-Dx SARS and WHO-PCR on 69 clinical samples was 97% with a sensitivity at 100% (40/40) and specificity at 93% (27/29). | 2020-04-28 |
| 32341143 | The clinical presentation of COVID-19 is fairly non-specific, and symptoms overlap with other seasonal respiratory infections concurrently circulating in the population. […] Furthermore, it is estimated that up to 80% of infected individuals experience mild symptoms or are asymptomatic, confounding efforts to reliably diagnose COVID-19 empirically. […] In the present study, we have evaluated the analytical sensitivity and clinical performance of four SARS-CoV-2 molecular diagnostic assays granted Emergency Use Authorization by the FDA using nasopharyngeal swabs from symptomatic patients: the New York SARS-CoV-2 Real-time Reverse Transcriptase (RT)-PCR Diagnostic Panel (Modified CDC), the Simplexa COVID-19 Direct (Diasorin Molecular), GenMark ePlex SARS-CoV-2 assay (GenMark) and the Hologic Panther Fusion® SARS-CoV-2 assay (Hologic). […] This information is crucial for both laboratories and clinical teams, as decisions on which testing platform to implement are made. | 2020-04-28 |
| 32341311 | With the onset of the COVID-19 pandemic, the shifting of clinical care to telemedicine visits has been hastened. | 2020-05-16 |
| 32341442 | Importantly, however, there is no clinical or experimental evidence supporting that ARBs and ACEIs either augment the susceptibility to SARS-CoV-2 or aggravate the severity and outcomes of COVID-19 at present. | 2020-04-30 |
| 32341519 | Timely analysis of the laboratory characteristics associated with 2019 novel coronavirus pneumonia (COVID-19) can assist with clinical diagnosis and prognosis. […] This study is a collection of clinical data from 54 hospitalized adult patients diagnosed with COVID-19 in the Zhongfa Xincheng district of China at Tongji Hospital of Huazhong University of Science and Technology from January 28, 2020 to February 11, 2020. | 2020-05-08 |
| 32341630 | Symptoms usually include fever, cough, difficulty in breathing, pneumonia, severe acute respiratory syndrome. | 2020-04-30 |
| 32341721 | The clinical, biological and radiological data of the patients who developed a nosocomial infection with SARS-Cov-2 were collected from the computerized medical record. | 2020-04-28 |
| 32341722 | The symptoms associated with COVID-19 are mainly characterized by a triad composed of fever, dry cough and dyspnea. […] However, digestive symptoms have also been reported; at first considered as infrequent, they in fact seem to affect (to some extent) more than half of patients. […] The symptoms are mainly manifested by anorexia, diarrhea, nausea and/or vomiting and abdominal pain. […] Even though prognosis is associated with lung injury, digestive symptoms seem significantly more frequent in patients presenting with severe COVID-19 infection. […] Digestive forms, which may be isolated or which can precede pulmonary symptoms, have indeed been reported, with diarrhea as a leading clinical sign. […] No data exist on the interest of digestive endoscopy in cases of persistent digestive symptoms. […] Fecal-oral transmission of the infection is possible, especially insofar as viral shedding in stools seems frequent and of longer duration than at the ENT level, including in patients with negative throat swab and without digestive symptoms. | 2020-04-28 |
| 32341913 | Clinical symptoms of coronavirus infections can range from relatively mild (similar to the common cold) to severe (bronchitis, pneumonia, and renal involvement). | 2020-04-30 |
| 32341943 | On 31 December 2019, the Wuhan Municipal Committee of Health and Healthcare (Hubei Province, China) reported that there were 27 cases of pneumonia of unknown origin with symptoms starting on the 8 December. […] The Ministry of Health summoned the Specialties Societies to prepare a clinical protocol for the management of COVID-19. | 2020-04-30 |
| 32342049 | He was treated conservatively, with complete clinical recovery and resolution of his EKG abnormalities. | 2020-04-28 |
| 32342112 | We further compiled expert consensus regarding management of FPMRS patients in the virtual setting, scenarios when in-person visits are necessary, symptoms that should alert providers, and specific considerations for FPMRS patients with suspected or confirmed COVID-19. | 2020-05-01 |
| 32342140 | The aim of this manuscript is to review the available strategies in the international literature to efficiently and safely return to both normal orthopaedic surgical activities and to normal outpatient clinical activities in the aftermath of a large epidemic or pandemic. […] After restrictions will be lifted, clinical and surgical volume will progressively increase. | 2020-05-29 |
| 32342191 | To illustrate the [18F]FDG-PET/CT findings in patients affected by cancer with clinical diagnosis of Covid-19 METHODS: We retrospectively reviewed the cases of patients who showed pulmonary involvement unrelated to cancer metastases on March 13 and 16 2020. […] At 1-week follow-up, 2/5 patients experienced the onset of mild respiratory symptoms. […] The [18F]FDG-PET/CT can identify probable Covid-19 disease in the absence or before symptoms onset and can guide patient management. | 2020-05-28 |
| 32342252 | In a preliminary clinical study, we observed that the combination of hydroxychloroquine and azithromycin was effective against SARS-CoV-2 by shortening the duration of viral load in Covid-19 patients. | 2020-05-18 |
| 32342479 | The aim of this study was to investigate the clinical characteristics of Corona Virus Disease 2019 in Taizhou, China. […] All patients with confirmed Corona Virus Disease 2019 were enrolled, and their clinical data were gathered by reviewing electronic medical records. […] Common symptoms included dry cough (81.4%), fever (75.2%), anorexia (42.8%), fatigue (40.7%), chest tightness (32.4%), diarrhea (26.9%) and dizziness (20%). […] Treatments of COVID-19 is still experimental and more clinical trials are needed. | 2020-05-07 |
| 32342566 | Statistically significant differences in chemosensitive recovery were detected based on age and distance from the onset of clinical manifestations. […] Olfactory and gustatory dysfunctions represent common clinical findings in COVID-19 patients. […] Otolaryngologists and head-neck surgeons must by now keep this diagnostic option in mind when evaluating cases of ageusia and nonspecific anosmia that arose suddenly and are not associated with rhinitis symptoms. | 2020-05-29 |
| 32342609 | Most cases are mild, but a significant minority of patients develop moderate to severe respiratory symptoms, with the most severe cases requiring intensive care and/or ventilator support. […] We hypothesize that non-invasive vagus nerve stimulation (nVNS) might provide clinical benefits in patients with respiratory symptoms similar to those associated with COVID-19. […] In case 2, the patient experienced immediate and consistent relief from symptoms of chest tightness and shortness of breath, as well as an improved ability to clear his lungs. […] Preliminary observations and a strong scientific foundation suggest that nVNS might provide clinical benefits in patients with COVID-19 via multiple mechanisms. | 2020-05-13 |
| 32342636 | From the first reports, ageusia and anosmia appear to be frequent clinical features in coronavirus disease 19 (COVID-19) patients. | 2020-04-28 |
| 32342676 | COVID-19 patients may be asymptomatic or show various clinical manifestations, including acute symptoms such as fever, fatigue, sore throat; pneumonia presenting as acute respiratory distress syndrome; and multiple organ failure. […] As COVID-19 has such varied clinical manifestations and case fatality rates, no standard antiviral therapy regimen has been established other than supportive therapy. […] In the present guideline, we aim to introduce potentially helpful antiviral and other drug therapies based on in vivo and in vitro research and clinical experiences from many countries. | 2020-04-28 |
| 32342677 | Since clinical feature of COVID-19 has not been fully evaluated yet, empirical antibacterial agents are frequently combined for the treatment of COVID-19 in addition to antiviral agents, concerning co-existing bacterial pathogens. | 2020-04-28 |
| 32342849 | We report a 71-year-old woman with documented viral shedding (based on reverse transcription-polymerase chain reaction (RT-PCR) testing) of SARS-CoV-2 for 60 days from the onset of symptoms (55 days from her first positive test and 36 days after complete resolution of symptoms). | 2020-04-28 |
| 32342863 | This joint ESTRO-ASTRO practice recommendation established pragmatic and balanced consensus recommendations in common clinical scenarios of radiotherapy for lung cancer in order to address the challenges of the COVID-19 pandemic. | 2020-05-29 |
| 32342870 | During more than one and a half months of uninterrupted radiation oncology clinical operation through the worst of the Wuhan outbreak, no known COVID-19 infection occurred at our radiotherapy center to our patients or employees. | 2020-05-27 |
| 32342872 | The general recommendations to mitigate the potential detriment of an unexpected shortage of radiotherapy facilities include: (1) maintain current standards of care as long as possible (2) refer to another specialist paediatric radiotherapy department with similar level of expertise (3) prioritise use of existing radiotherapy resources to treat patients with tumours where radiotherapy has the most effect on clinical outcome (4) use chemotherapy to defer the start of radiotherapy where timing of radiotherapy is not expected to be detrimental (5) active surveillance for low-grade tumours if appropriate and (6) consider iso-effective hypofractionated radiotherapy regimens only for selected patients with predicted poor prognosis. […] It has wider applications for the optimal utilisation of facilities, to improve clinical outcome in low- and middle-income countries, where limited resources continue to be a challenge. | 2020-05-27 |
| 32342928 | The viral load of SARS-CoV-2 RNA in the upper respiratory tract was significantly higher during the first week and peaked at 4-6 days after onset of symptoms, during which it can be potentially sampled. | 2020-04-30 |
| 32343122 | While clinicians are focused on correcting respiratory homeostasis, echoing the original SARS, SARS-CoV-2 is also invading other end-organs, which may not exhibit overt clinical features. […] In our previous viewpoint, we implored our colleagues to recognize the covert tactics of SARS-CoV-2 and emphasized that symptoms like anosmia, dysgeusia, ataxia, and altered mental status could be early signs of the neurotropic potential of this virus. | 2020-05-11 |
| 32343162 | The COVID-19 pandemic has greatly impacted dermatology clinical trial operations due to mandated governmental and institutional shut-downs and newly implemented restrictions. | 2020-05-14 |
| 32343342 | We discuss the implications of the COVID-19 global pandemic with respect to: (1) increased risk of infection and poor outcomes among people with schizophrenia, (2) anticipated adverse mental health consequences for people with schizophrenia, (3) considerations for mental health service delivery in inpatient and outpatient settings, and (4) potential impact on clinical research in schizophrenia. […] Recommendations emphasize rapid implementation of measures to both decrease the risk of COVID-19 transmission and maintain continuity of clinical care and research to preserve safety of both people with schizophrenia and the public. | 2020-05-06 |
| 32343363 | Its initial emergence in a skilled nursing facility (SNF) not only highlighted the vulnerability of its patients and residents, but also the limited clinical support that led to national headlines. | 2020-05-30 |
| 32343408 | On 26 March 2020 we searched CENTRAL, MEDLINE, Embase, WHO Global Index Medicus, and the WHO International Clinical Trials Registry Platform. […] A retrospective case-control study and a cohort study assessed diarrhoea in children under the age of five years and self-reported reproductive tract symptoms in women, respectively. […] Similarly, it was very uncertain whether the rate of women experiencing symptoms of reproductive tract infection differed between women cleaning hands with ash compared with cleaning hands using soap (RR 0.48, 95% CI 0.12 to 1.86; very low-certainty evidence) or when compared with handwashing with water only or not washing hands (RR 0.50, 95% CI 0.13 to 1.96; very low-certainty evidence). | 2020-04-29 |
| 32343410 | The clinical features and treatment of pulmonary tuberculosis patients with COVID-19 is unclear and understudied. | 2020-04-28 |
| 32343415 | Here, 26 cases of COVID-19 in Jinan, China, were examined and shown to be mild or with common clinical symptoms, and no case of severe symptoms was found among these patients. | 2020-05-05 |
| 32343454 | These changes raise a lot of questions regarding patient triage and treatment decisions in clinical situations when it is unclear if the workup and management can be postponed. | 2020-05-29 |
| 32343593 | The initial gastrointestinal symptoms that appear early during the course of Covid-19 support this hypothesis. […] In this special review, we describe the interaction of SARS-CoV-2 with the cell and enterocyte and its potential clinical implications. | 2020-05-25 |
| 32343658 | This article is based on a selective literature search in PubMed and ClinicalTrials.gov, followed by an assessment of the ongoing clinical trials that were revealed by the search. […] The potential therapeutic efficacy and tolerability of these and other active substances remain to be investigated in clinical trials. […] At present, more than 80 trials on COVID-10 have already been registered with Clinical- Trials.gov. […] Clinical trials are now indispensable in order to determine the true clinical benefits and risks of the substances that have been found to be active against SARSCoV- 2 in vitro. | 2020-05-01 |
| 32343745 | Clinical characteristics, laboratory parameters, and outcomes were compared and analyzed between males and females. […] Eleven laboratory parameters showed significant differences between male and female patients, and six of them were higher during the whole clinical course in patients who died than in patients who were discharged. […] We highlighted sex-specific differences in clinical characteristics and prognosis. | 2020-05-13 |
| 32343947 | However, measures of respiratory muscle performance are not routinely performed in clinical practice, including those with symptoms such as dyspnea. | 2020-04-30 |
| 32343948 | Validation studies of serological antibody tests must be properly designed for clinical, epidemiological and Public Health objectives such as confirmation of suspected COVID-19 cases, certification of seroconversion after infection, and epidemiological surveillance. | 2020-05-18 |
| 32343968 | Both patients progressed to sHLH despite treatment with tocilizumab, and one developed viral myocarditis, challenging the safety and clinical usefulness of tocilizumab in the treatment of COVID-19-induced CRS. […] These cases highlight the need for clinical trials to determine optimal patient selection and timing for the use of tocilizumab during this disease process. | 2020-05-06 |
| 32344011 | While the clinical status, in particular peripheral oxygen saturation (SpO2) levels, and concurrent comorbidities of COVID-19 patients largely determine the need for their admittance to ICUs, several laboratory parameters may facilitate the assessment of disease severity. | 2020-05-29 |
| 32344056 | Eosinophil levels vary dramatically in a number of clinical settings, especially following eosinophil-targeted therapy, which is now available to selectively deplete these cells. | 2020-05-24 |
| 32344166 | A wealth of data has been generated since its emergence in December 2019, and it is vital for clinicians to keep up with this data from across the world at a time of uncertainty and constantly evolving guidelines and clinical practice. […] Here we provide an update for clinicians on the recent developments in the virology, diagnostics, clinical presentation, viral shedding, and treatment options for COVID-19 based on current literature. […] We considered published peer-reviewed papers and non-peer-reviewed pre-print manuscripts on COVID19 and related aspects with an emphasis on clinical management aspects. […] We describe the virological characteristics of SARS-CoV-2 and the clinical course of COVID-19 with an emphasis on diagnostic challenges, duration of viral shedding, severity markers and current treatment options. | 2020-05-22 |
| 32344167 | Baseline clinical and laboratory characteristics were comparable between the two groups. […] The median time from onset of symptoms to SARS-CoV-2 turning negative was 18 days (interquartile range (IQR) 12-21) in the umifenovir group and 16 days (IQR 11-21) in the control group (p 0.42). […] A randomized control clinical trial is needed to assess the efficacy of umifenovir. | 2020-05-08 |
| 32344177 | In vivo it showed efficacy, especially when combined with azithromycin in a preliminary clinical trial. | 2020-05-28 |
| 32344226 | The patients show flu-like symptoms with a dry cough, sore throat, high fever, and breathing problems. […] It was analyzed that a combination of antiviral drugs with hydroxyl-chloroquine and azithromycin (with the consultation of a medical practitioner) may be the best option to treat the patients, depending on the patient’s conditions and symptoms. | 2020-05-19 |
| 32344276 | Coronaviruses have been known to cause common cold symptoms. […] COVID-19 infections have been described as causing more severe respiratory infections and the symptoms reported by authors from Wuhan, China have not specifically included anosmia. […] Most had either no symptoms or mild respiratory symptoms. | 2020-05-12 |
| 32344310 | A novel virus named 2019 novel coronavirus (2019-nCoV/SARS-CoV-2) causes symptoms that are classified as coronavirus disease (COVID-19). […] It was also revealed that alternative treatments currently being considered for COVID-19 such as chloroquine and hydroxychloroquine by increasing hemoglobin production and increasing hemoglobin availability for oxygen binding and acetazolamine (for the treatment of altitude sickness) by causing hyperventilation with associated increasing levels of oxygen and decreasing levels of carbon dioxide in the blood may significantly ameliorate COVID-19 respiratory symptoms. […] In conclusion, is recommend, given HBOT, pRBC, and ESA therapies are currently available and routinely utilized in the treatment of other conditions, that such therapies be tried among COVID-19 patients with serious respiratory conditions and that future controlled-clinical trials explore the potential usefulness of such treatments among COVID-19 patients with respiratory conditions. | 2020-05-18 |
| 32344314 | Monalizumab is an inhibiting antibody against NKG2A which can restore the function of CD8 + T and NK cells in cancers, successfully ceasing tumor progression with no significant side effects in Phase 2 clinical trials. | 2020-05-18 |
| 32344317 | In this review paper we expose the challenges of cancer management in the era of SARS-CoV-2, the epidemiological, clinical, pathological and radiological characteristics of the disease in cancer patients and its outcomes on this population. | 2020-05-28 |
| 32344320 | To explore the clinical course and its dynamic features of immune status in COVID-19 patients and find predictors correlated with severity and prognosis of COVID-19. […] The electronic medical records of 204 patients with COVID-19 pneumonia confirmed by nucleic acid testing were retrospectively collected and analyzed. | 2020-05-27 |
| 32344321 | Data on demographic characteristics, baseline clinical characteristics, and the levels of IL-6, CRP, and PCT on admission were collected. | 2020-05-27 |
| 32344370 | The available technologies of Industry 4.0 could also help the detection and diagnosis of COVID-19 and other related problems and symptoms. | 2020-05-27 |
| 32344422 | These recommendations for physicians who perform bronchoscopy will help to protect those patients (un)-affected by the current COVID-19 pandemic, minimize the risk of transmission, and maintain clinical care for all patients. | 2020-05-29 |
| 32344439 | Additionally a retrospective observational cohort study with descriptive analysis of epidemiological and clinical data of COVID patients admitted until March 31st was performed. […] In the upcoming pandemic, adequate COVID management and care could be secured by a collaborative approach with inclusion of administrative departments, clinical disciplines and theoretical institutes of the University Medical Center Freiburg. | 2020-05-22 |
| 32344441 | As such, clinical protocols and practice on labor and delivery units must adapt to optimize the safety of patients and health care workers and to better conserve health care resources. | 2020-04-28 |
| 32344449 | These doses are higher than recommended for malaria chemoprophylaxis, and clinical trials are needed to establish safety and efficacy. | 2020-04-28 |
| 32344456 | These recommendations focus on seven specific domains including: planning of resources and staffing; modifying the clinical environment; preparing equipment, supplies and drugs; selecting appropriate personal protective equipment; providing adequate oxygen therapy; assessing for and safely performing regional anaesthesia procedures; and monitoring during the conduct of anaesthesia and post-anaesthetic care. | 2020-05-14 |
| 32344688 | The practicality and clinical suitability of four face shields printed using a fused deposition modeling printer were examined. […] To assess the clinical suitability, each face shield was worn for one hour by 10 clinicians and rated using a visual analogue scale. […] For clinical suitability, a chosen design should allow sufficient space for goggles and N95 respirators as well as maximum coverage of the facial area. | 2020-05-19 |
| 32345226 | To date, the clinical characteristics of COVID-19 patients in the non-Wuhan areas of Hubei Province in China have not been described. […] We retrospectively analyzed the clinical characteristics and treatment progress of 91 patients diagnosed with COVID-19 in Jingzhou Central Hospital. | 2020-04-30 |
| 32345343 | This article discusses how ICU professionals (e.g., physicians, nurses, physiotherapists, pharmacologists) can use our knowledge and resources to limit the burden of delirium on patients by reducing modifiable risk factors despite the imposed heavy workload and difficult clinical challenges posed by the pandemic. | 2020-04-30 |
| 32345443 | In view of the current pandemic by SARS-CoV-2 it deems essential to understand the key concepts about the infection: its epidemiological origin, presentation, clinical course, diagnosis and treatment (still experimental in many cases). | 2020-05-01 |
| 32345446 | Literatures on the epidemiology, clinical characteristics and infection control measures of COVID-19 were reviewed, practical knowledge from first-line otolaryngologists in China, the United States, and Brazil were reviewed and collated. […] It was recommended that otolaryngology professionals should improve screening in suspected patients with relevant nasal and pharyngeal symptoms and signs, suspend non-emergency consultations and examinations in clinics, and rearrange the working procedures in operating rooms. | 2020-05-03 |
| 32345579 | This study explores the clinical characteristics of patients with diabetes with severe covid-19, and the association of diabetes with survival duration in patients with severe covid-19. […] In this single-center, retrospective, observational study, the clinical and laboratory characteristics of 193 patients with severe covid-19 were collected. 48 patients with severe covid-19 had diabetes, and 145 patients (ie, the controls) did not have diabetes. | 2020-04-30 |
| 32345702 | However, little is known about the clinical characteristics of kidney-related complications, including hematuria, proteinuria, and AKI. […] In this retrospective, single-center study in China, we analyzed data from electronic medical records of 333 hospitalized patients with COVID-19 pneumonia, including information about clinical, laboratory, radiologic, and other characteristics, as well as information about renal outcomes. […] Although proteinuria, hematuria, and AKI often resolved in such patients within 3 weeks after the onset of symptoms, renal complications in COVID-19 were associated with higher mortality. | 2020-05-30 |
| 32345728 | Pooled descriptive statistics of clinical data and comorbidities were examined. […] Emerging literature suggests a daunting clinical relationship between COVID-19 and neurologic illness. | 2020-05-29 |
| 32345861 | These conditions are engendering high levels of fear and anxiety in the short-term, and place individuals at risk for persistent stress-exposure syndromes, sub-clinical mental health symptoms, and professional burnout in the long-term. | 2020-05-19 |
| 32346093 | Alongside investigations into the virology of SARS-CoV-2, understanding the fundamental physiological and immunological processes underlying the clinical manifestations of COVID-19 is vital for the identification and rational design of effective therapies. | 2020-05-07 |
| 32346373 | The questionnaire, administered through the WeChat program, obtained demographic data and asked self-design questions related to the COVID-19 outbreak, insomnia/depressive/anxiety symptoms, and stress-related symptoms. […] We used a logistic regression analysis to examine the associations between sociodemographic factors and insomnia symptoms. […] Five-hundred-and-sixty-four (36.1%) participants had insomnia symptoms according to the Insomnia Severity Index (ISI) (total score ≥ 8). […] A multiple binary logistic regression model revealed that insomnia symptoms were associated with an education level of high school or below (OR = 2.69, p = 0.042, 95% CI = 1.0-7.0), being a doctor (OR = 0.44, p = 0.007, 95% CI = 0.2-0.8), currently working in an isolation unit (OR = 1.71, p = 0.038, 95% CI = 1.0-2.8), is worried about being infected (OR = 2.30, p < 0.001, 95% CI = 1.6-3.4), perceived lack of helpfulness in terms of psychological support from news or social media with regard to COVID-19 (OR = 2.10, p = 0.001, 95% CI = 1.3-3.3), and having very strong uncertainty regarding effective disease control (OR = 3.30, p = 0.013, 95% CI = 1.3-8.5). […] Our study found that more than one-third of the medical staff suffered insomnia symptoms during the COVID-19 outbreak. | 2020-05-05 |
| 32346490 | To date, no licensed antiviral drugs or vaccines are available against COVID-19 although several clinical trials are underway to test possible therapies. | 2020-05-01 |
| 32346492 | Based on previous experience of blood purification for patients with severe acute respiratory syndrome and Middle East respiratory syndrome combined with clinical front-line practice, we developed a blood purification protocol for patients with severe COVID-19. | 2020-05-01 |
| 32346593 | The main clinical symptoms of COVID-19 are fever, fatigue, and a dry cough. […] This paper reviews the published literature, guidelines and consensus, and summarizes the clinical and imaging characteristics of COVID-19, in order to provide a reliable basis for early diagnosis and treatment. | 2020-05-11 |
| 32346594 | All clinical data and the chest CT on admission were retrospectively reviewed and analyzed. […] The interval from onset symptoms to first chest CT scan was 8 days. | 2020-05-01 |
| 32346676 | These community-led initiatives will fill key knowledge gaps to tackle crucial clinical questions on the complexities of infection with the causative coronavirus SARS-Cov-2 in the large, heterogeneous group of vulnerable patients with cancer. | 2020-05-01 |
| 32346785 | Data was obtained regarding demographics and clinical and surgical practice during the pandemic. | 2020-05-07 |
| 32346873 | We investigated the epidemiological and clinical features of patients infected by SARS-CoV-2 without any symptoms. […] The demographic characteristics, clinical data, treatment, and outcomes of SARS-CoV-2 infected patients without any symptoms were analyzed. […] Patients without any symptoms but with SARS-CoV-2 exposure should be closely monitored and tested for SARS-CoV-2 both in anal and throat swabs to excluded the infection. | 2020-05-13 |
| 32347067 | Therefore, the optimized assay developed in this study can be used in screening and early clinical diagnosis. […] Our work provides a tool to facilitate rapid clinical diagnosis of COVID-19. | 2020-05-01 |
| 32347200 | Healthcare workers (n = 803) with mild symptoms were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (n = 90 positive) and asked to complete a symptom questionnaire. […] A predictive model based on these symptoms showed moderate discriminative value (sensitivity: 91.2%; specificity: 55.6%). | 2020-05-01 |
| 32347201 | We describe clinical characteristics, treatments and outcomes of 44 Caucasian patients with coronavirus disease (COVID-19) at a single hospital in Pavia, Italy, from 21-28 February 2020, at the beginning of the outbreak in Europe. | 2020-05-04 |
| 32347453 | The department of surgery played a leading role in establishing clinical protocols, guidelines, and policies in preparation for a surge of COVID-19 patients. […] A multidisciplinary approach with input from clinical and nonclinical stakeholders is critical to successful crisis planning. | 2020-05-05 |
| 32347618 | Their age, sex, diagnosis of disease, requirement for emergent intervention, and their medical records about COVID-19 were obtained. | 2020-05-22 |
| 32347747 | Thus, by using the safe over-the-counter drug melatonin, we may be immediately able to prevent the development of severe disease symptoms in coronavirus patients, reduce the severity of their symptoms, and/or reduce the immuno-pathology of coronavirus infection on patients’ health after the active phase of the infection is over. | 2020-04-29 |
| 32347772 | Identified strategies included early recognition of the threat and rapid activation of national response protocols led by national leadership; rapid establishment of diagnostic capacity; scale-up of measures for preventing community transmission; and redesigning the triage and treatment systems, mobilizing the necessary resources for clinical care. […] Key recommendations include (1) recognize the problem, (2) establish diagnostic capacity, (3) implement aggressive measures to prevent community transmission, (4) redesign and reallocate clinical resources for the new environment, and (5) work to limit economic impact through and while prioritizing controlling the spread and impact of COVID-19. | 2020-05-04 |
| 32347975 | The European AIDS Clinical Society states the lack of evidence for a higher COVID-19 infection rate among people living with HIV (PLHIV) and there is a few published literature on the course of COVID-19 co-infection in PLHIV. | 2020-04-29 |
| 32347997 | When thoughtfully applied in the appropriate clinical context, small practice adaptations like this can facilitate telehealth solutions that diminish unnecessary exposure for patients, their caregivers, and health care staff. | 2020-05-29 |
| 32348042 | This review summarizes current knowledge on the incidence and clinical course of SARS-CoV-2 infection in patients with solid organ transplantation. | 2020-05-01 |
| 32348047 | Older patients do not always present with typical symptoms (fever, cough and dyspnoea) but sometimes are and remain asymptomatic (contact screening), or have aspecific presentations (altered general condition, falls, delirium, unusual fatigue). | 2020-05-01 |
| 32348049 | In this article, we discuss the known or suspected interactions between the virus and the kidneys, as well as their clinical presentations. | 2020-05-01 |
| 32348051 | These patients should therefore isolate themselves and remain alert to the occurrence of other symptoms suggestive of the infection and/or be tested. | 2020-05-01 |
| 32348052 | Any possible clinical impact of these treatments on COVID-19 infection remains to be clarified; in the meantime, they should be continued. | 2020-05-01 |
| 32348053 | At an individual level, they have to adapt their clinical practice and consider specific issues of teleconsultations to address patient’s needs. | 2020-05-04 |
| 32348055 | However recently acquired data and clinical experience suggest that COVID-19-related ARDS presents some specificities that will be summarized in the present article. | 2020-05-01 |
| 32348056 | Alongside organizational challenges, clinical issues such as rapid respiratory distress, clinical suspicions with negative PCR and treatment uncertainties in the absence of sufficient evidence were overcome. | 2020-05-01 |
| 32348111 | Therefore, it is important to screen the COVID-19 patients for neurological symptoms as well as possibility of the collapse of the respiratory center in the brainstem should be investigated in depth. | 2020-05-22 |
| 32348166 | Epidemiological, demographic, clinical and laboratory data were collected, analyzed and compared between these groups. | 2020-04-29 |
| 32348339 | Our study has been registered with the Chinese Clinical Trial Registry, the registration number: ChiCTR2000029829. | 2020-05-04 |
| 32348545 | To describe the cutaneous manifestations of COVID-19 disease and to relate them to other clinical findings METHODS: Nationwide case collection survey of images and clinical data. […] Using a consensus, we described 5 clinical patterns. […] We later described the association of these patterns with patient demographics, timing in relation to symptoms of the disease, severity, and prognosis. […] Vesicular eruptions appear early in the course of the disease (15% before other symptoms). […] The pseudo-chilblain pattern frequently appears late in the evolution of the COVID-19 disease (59% after other symptoms), while the rest tend to appear with other symptoms of COVID-19. […] Results are similar for confirmed and suspected cases, both in terms of clinical and epidemiological findings. | 2020-04-29 |
| 32348581 | We describe a small-team “cohorting” protocol including guidelines for faculty and resident in common clinical scenarios with attention paid to the risk of common otolaryngologic procedures. […] A rotating small-team approach was implemented at each clinical site, limiting interaction between department members but providing comprehensive coverage. […] Faculty were involved at the earliest phase of clinical interactions. | 2020-05-06 |
| 32348582 | Some are continuing routinely, especially those who are overseeing clinical trials that could offer life-saving therapies, particularly against the novel coronavirus. | 2020-05-02 |
| 32348588 | The disease caused by SARS-CoV-2, coronavirus disease 2019 (COVID-19), presents flu-like symptoms which can become serious in high-risk individuals. […] Here, we provide an overview of the known clinical features and treatment options for COVID-19. […] We included publications from 1 January 2019 to 3 April 2020 which focused on clinical features and treatments. […] The main symptoms of COVID-19 are fever, cough, fatigue, slight dyspnoea, sore throat, headache, conjunctivitis and gastrointestinal issues. […] Specifically designed randomized clinical trials are needed to determine the most appropriate evidence-based treatment modality. | 2020-05-13 |
| 32348591 | This document provides clinical practice guidelines based on available evidence to date to balance the risks of SARS-CoV-2 exposure with the risks associated with dysphagia. […] Despite significant limitations in clinical service provision during the pandemic of COVID-19, a safe and reasonable dysphagia care pathway can still be implemented with modifications of setup and application of newer technologies. | 2020-05-11 |
| 32348783 | Early clinical evidence suggests that severe cases of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are frequently characterized by hyperinflammation, imbalance of renin-angiotensin-aldosterone system, and a particular form of vasculopathy, thrombotic microangiopathy, and intravascular coagulopathy. […] We discuss the underlying pathogenesis and the interaction between multiple systems, resulting in propagation of immunothrombosis, which through investigation in the coming weeks, may lead to both an improved understanding of COVID-19 pathophysiology and identification of innovative and efficient therapeutic targets to reverse the otherwise unfavorable clinical outcome of many of these patients. | 2020-05-18 |
| 32349014 | Without the protections provided to paid health care workers, students are uniquely disadvantaged within the medical hierarchy; these inequalities must be addressed before medical students are safely reintegrated into clinical roles. […] Although graduating medical students and institutional leadership may worry that suspending clinical rotations might prevent students from completing graduation requirements, the authors argue the ethical obligation to “flatten the curve” supersedes usual teaching responsibilities. | 2020-05-08 |
| 32349033 | These platforms can facilitate routine diagnostic assays in certified clinical labs. | 2020-04-29 |
| 32349035 | Studies about the biological symptoms of SARS-CoV-2 in clinic animal and humans will manipulate an understanding the origin of pandemic crisis. | 2020-04-29 |
| 32349045 | The pressure to the health services worldwide has been unprecedented.The redeployment of staff and resources to treat more efficiently COVID-19 cases along with the need to reduce disease transmission has affected the field of electrophysiology among many others.Amendments to clinical pathways are obligatory in this perspective to continue to provide the necessary health services to the people who need them while at the same time infection control and prevention are not compromised by inadvertent disease transmission or unnecessary use of resources.We aim to providea guide of the logistic aspects of electrophysiology procedures derived fromour Tertiary Cardiac Centre duringthe current COVID-19 pandemic. | 2020-05-01 |
| 32349053 | However, once again, pregnant and breastfeeding women are excluded from participating in clinical trials during this pandemic. […] This “protection by exclusion” of pregnant women from drug development and clinical therapeutic trials, even during epidemics and pandemics, is not unprecedented. […] Therefore, we recommend and urge the scientific community and professional societies that, without clear justification for exclusion, pregnant women should be given the opportunity to be included in clinical trials for COVID-19 based on the concepts of justice, equity, autonomy, and informed consent. | 2020-05-26 |
| 32349055 | In this hypothesis paper, we suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may induce intravascular pulmonary thrombosis, which may result in the rapid worsening of clinical conditions and, eventually, exitus. | 2020-05-30 |
| 32349133 | Thus, we performed a systematic review of COVID-19 literature reporting measures of clotting activation to assess if changes are detectable in this setting and their relationship with clinical severity. | 2020-04-29 |
| 32349183 | Clinical questions were collated, and an evidence report was rapidly generated and disseminated. | 2020-04-29 |
| 32349517 | The outbreak caused by COVID-19 is causing a major challenge to clinical management and a worldwide threat to public health. […] Therefore, on the basis of epidemiology and virology information, we reviewed relevant meta-analysis and clinical studies of anti-coronavirus therapeutics by TCM, in the aspect of mortality, symptom improvement, duration and dosage of corticosteroid, incidence of complications and the like. […] In addition, we also summarized preclinical rationale for anti-coronavirus activity by TCM in terms of virion assembly and release, as well as viral entry and replication, which could be a useful contribution for figuring out effective Chinese herbal medicine (CHM) for coronavirus, including ingredients from single monomeric compounds, Chinese herbs, Chinese herb extracts and Chinese herb formulas, or potential targets for medicine. […] We would like to see these relevant studies, ranging from basic researches to clinical application, could provide some idea on effects of CHM to combat COVID-19 or other coronaviruses, and also offer new thinking for the exploration of therapeutic strategies under the guidance of TCM. | 2020-04-30 |
| 32349772 | The SARS-CoV-2 causes a clinical syndrome designated coronavirus disease 2019 (COVID19) with a spectrum of manifestations ranging from mild upper respiratory tract infection to severe pneumonitis, acute respiratory distress syndrome (ARDS) and death. […] Few cases have been observed in children and adolescents who seem to have a more favorable clinical course than other age groups, and even fewer in newborn babies. […] This review provides an overview of the knowledge on SARS-CoV-2 epidemiology, transmission, the associated clinical presentation and outcomes in newborns and infants up to 6 months of life. | 2020-05-01 |
| 32349982 | Therefore, with World Scleroderma Foundation endorsement, experts from different specialties including rheumatology, virology and clinical immunology gathered virtually to answer to the main practical clinical questions regarding SARS-CoV-2 infection coming from both patients and physicians. | 2020-05-22 |
| 32350047 | While Food and Drug Administration (FDA) emergency use authorization (EUA) is required for clinical application of SARS-CoV-2 molecular tests, submission for EUA is currently a voluntary process for manufacturers of serologic assays. | 2020-04-30 |
| 32350048 | We compared the analytical performance of a laboratory developed test (LDT) developed in our clinical laboratory based on CDC primer sets and four commercially available, FDA emergency use authorized assays for SARS-CoV-2 (Cepheid, DiaSorin, Hologic Panther, and Roche Cobas) on a total of 169 nasopharyngeal swabs. | 2020-04-30 |
| 32350134 | The changes of clinical manifestations, computerized tomography (CT) scan image, and laboratory examinations were retrospectively analyzed. […] Fever returned to normal on the first day, and other symptoms improved remarkably within a few days. […] Preliminary data show that tocilizumab, which improved the clinical outcome immediately in severe and critical COVID-19 patients, is an effective treatment to reduce mortality. | 2020-05-22 |
| 32350161 | We retrospectively analyzed 303 patients diagnosed with COVID-19 and evaluated the clinical data of 240 patients who were discharged. | 2020-04-30 |
| 32350226 | For further validation, the assays were compared with the commercially available kits using SARS CoV-2 viral RNA and the clinical specimens obtained from COVID19-suspected individuals. […] The LightMix Modular SARS and Wuhan CoV E-gene (LN S&W-E) assay was highly sensitive for SARS-CoV-2, as was the N2 set, and both assays had perfectly consistent results with the clinical specimens. | 2020-04-30 |
| 32350632 | We aim to review available clinical and biomedical literature on cardiovascular risks of COVID-19. | 2020-05-04 |
| 32350686 | Several existing antiviral drugs, previously developed or used as treatments for severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), human immunodeficiency virus (HIV), and malaria, are being investigated as COVID-19 treatments and some of them are being used in clinical trials. […] There are currently no complete data available from large randomized clinical trials (RCTs) to provide clinical guidance on the use, dosing, or duration to validate the effective role, safety profile, and adverse effects of all of the trial drugs for prophylaxis or treatment of COVID-19. […] Therefore, for the better safety of patients with COVID-19, further clinical trials and large randomized controlled studies are needed to validate the effective role, safety profile, and adverse effects of all the potential drugs. | 2020-05-29 |
| 32350794 |
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2020-05-13 |
| 32350796 | The current global outbreak of COVID-19 represents a major challenge in terms of epidemiology, contagiousness, treatment, as well as clinical and radiological behavior of this disease. […] Radiological imaging plays a key role in the diagnostic process and during the monitoring of the clinical conditions especially of patients with severe symptoms. | 2020-05-13 |
| 32350861 | COVID-19 may also be such a defining moment for clinical pharmacology in terms of its role in drug development and therapy. | 2020-04-30 |
| 32350871 | A retrospective analysis of medical records and comparison of vaginal delivery outcomes between 10 pregnant women with clinical diagnosis of COVID-19 and 53 pregnant women without COVID-19 admitted to Zhongnan Hospital of Wuhan University between January 20 and March 2, 2020. […] Results of laboratory tests, imaging tests, and SARS-CoV-2 nucleic acid tests were also analyzed in neonates delivered by pregnant women with clinical diagnosis of COVID-19. […] Neonates delivered by pregnant women with clinical diagnosis of COVID-19 tested negative for SARS-CoV-2 infection. | 2020-05-19 |
| 32350928 | As an increasing number of patients with COVID-19 are treated with these agents and more evidence accumulates, there continues to be no high-quality clinical data showing a clear benefit of these agents for this disease. […] Given these facts and the growing uncertainty about these agents for the treatment of COVID-19, it is clear that at the very least thoughtful planning and data collection from randomized clinical trials are needed to understand what if any role these agents may have in this disease. […] In this article, we review the datasets that support or detract from the use of these agents for the treatment of COVID-19 and render a data informed opinion that they should only be used with caution and in the context of carefully thought out clinical trials, or on a case-by-case basis after rigorous consideration of the risks and benefits of this therapeutic approach. | 2020-05-06 |
| 32351037 | This study elaborates on the epidemiological and clinical characteristics of COVID-19 based on a descriptive study of the 333 patients infected with COVID-19 in Shanghai for the purpose of probing into this new disease and providing reference. […] 299 (89.8%) cases presented mild symptoms. […] 207 (62.2%) cases had fever symptoms at the onset, whereas 273 (82.0%) cases experienced fever before hospitalization. […] These findings suggest that most cases experienced fever symptoms and had mild pneumonia. | 2020-05-13 |
| 32351040 | Most individuals required hospitalization and presenting symptoms were similar to those of nontransplant individuals. | 2020-05-28 |
| 32351103 | In the early stages, thorax CT findings could be present even before the onset of symptoms, thorax CT has quite high sensitivity in COVID-19 patients with false negative RT-PCR results, and it has a great importance not only in diagnosis but also in follow up (6,7). | 2020-04-30 |
| 32351807 | In a recently published, single-center case series of 138 consecutive hospitalized patients with confirmed COVID-19, investigators reported that approximately 10% of patients initially presented with GI symptoms, prior to the subsequent development of respiratory symptoms. […] Common and often very subtle symptoms included diarrhea, nausea, and abdominal pain, with a less common symptom being nonspecific GI illness. | 2020-05-05 |
| 32351851 | Hydroxychloroquine therapy was started, and the patient responded favorably with improvement of symptoms. | 2020-05-05 |
| 32351860 | We report a case of COVID-19 infection that presented with symptoms suggestive of pneumonia. | 2020-05-05 |
| 32352081 | The recent outbreak of coronavirus disease (COVID-19) resulting from a distinctive severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to evolve in many countries and pose life-threatening clinical issues to global public health. […] Though a significant portion of SARS-CoV-2 infected individuals has been recovering from pathological symptoms, the impact of the COVID-19 on the structural and functional properties of the lungs, heart, brain and other organs at the post-recovery state remains unknown. […] However, a mild dose of the purified form of BoNT has been known to attenuate chronic cough, dyspnoea, pneumonia, acute respiratory failure, abnormal circulation, cardiac defects and various neurological deficits that have been recognised as the prominent clinical symptoms of COVID-19. | 2020-05-05 |
| 32352202 | The clinical presentation of European patients with mild-to-moderate Covid-19 infection is still unknown. […] To study the clinical presentation of Covid-19 in Europe. […] Epidemiological and clinical data were obtained through a standardized questionnaire. […] The most common symptoms were headache (70.3%), loss of smell (70.2%), nasal obstruction (67.8%), cough (63.2%), asthenia (63.3%), myalgia (62.5%), rhinorrhea (60.1%), gustatory dysfunction (54.2%) and sore throat (52.9%). […] The mean duration of Covid-19 symptoms of mild-to-moderate cured patients was 11.5±5.7 days. […] The prevalence of symptoms significantly varied according to age and sex. […] The clinical presentation of mild-to-moderate Covid-19 substantially varies according to the age and the sex characteristics of patients. | 2020-04-30 |
| 32352224 | Hence, several possible clinical scenarios in the setting of liver diseases have been postulated. […] First, patients with chronic liver disease may be more vulnerable to the severe clinical consequences of COVID-19, including oxygen desaturation and hypoxemia due to severe pneumonia or the cytokine storm 1;2 . | 2020-04-30 |
| 32352308 | OBJECTIVE. The purpose of this article is to review new pediatric lung disorders-including disorders that have occurred in recent years years such as severe acute respiratory syndrome (SARS), swine-origin influenza A (H1N1), Middle East respiratory syndrome (MERS), e-cigarette or vaping product use-associated lung injury (EVALI), and coronavirus disease (COVID-19) pneumonia-to enhance understanding of the characteristic imaging findings. CONCLUSION. Although the clinical symptoms of SARS, H1N1, MERS, EVALI, and COVID-19 pneumonia in pediatric patients may be nonspecific, some characteristic imaging findings have emerged or are currently emerging. | 2020-04-30 |
| 32352397 | Clinical characteristics and hemocyte counts of severe and non-severe COVID patients were collected. […] A concordance index (C-index), calibration curve, decision curve and the clinical impact curve were calculated to assess the predictive accuracy. […] A total of 82.8% of severe patients had lymphopenia after the onset of symptoms, and as the disease progressed, there was marked lymphopenia. […] The C-index (0.821 [95% CI, 0.746-0.896]), calibration curve, decision curve and the clinical impact curve showed that the nomogram can be used to predict the disease progression in COVID-19 patients accurately. | 2020-04-30 |
| 32352401 | Although the clinical and laboratory characteristics of this illness have been reported in patients from China and Europe, data are scant in the United States. […] Presenting signs and symptoms, laboratory and imaging findings, treatment, and complications were recorded from electronic medical records (EMRs). […] The most common presenting symptoms were fever (94%), cough (88%), and dyspnea (81%). | 2020-05-05 |
| 32352450 | Since the outbreak of the pandemic, anecdotal observations have been accumulating rapidly that sudden anosmia and dysgeusia are peculiar symptoms associated with the COVID-19 infection. […] Hopkins, as President of British Rhinological Society, published a letter describing “the loss of sense of smell as a marker of COVID-19 infection” and proposed that adults presenting with anosmia but no other symptoms should self-isolate for seven days. […] Only 51% reported the recognized symptoms of cough or fever. | 2020-04-30 |
| 32352535 | We provide a comprehensive review of the clinical course of COVID-19, its comorbidities, and mechanistic considerations for future therapies. | 2020-05-22 |
| 32352576 | The authors evaluated the clinical features and outcomes of five pregnant patients with COVID-19 at term, whose delivery was uneventful and led to favorable perinatal outcomes for both mother and neonate. […] Centers should therefore be meticulous in their approach to a SARS-CoV-2+ pregnancy to optimize clinical outcomes for both mother and child. | 2020-04-30 |
| 32352913 | With this report we aimed to share our concerns, clinical management, maternal and neonatal outcomes, and to present our current circuits and adjustments regarding the COVID-19 pandemic in our maternity hospital. | 2020-04-30 |
| 32352957 | In each city, the objective was to test all shelter residents and staff members at each assessed facility, irrespective of symptoms. | 2020-05-04 |
| 32353223 | Demographic and daily clinical data were collected to identify predictors of early mortality. | 2020-05-05 |
| 32353347 | Cases were older than the general population (mean age 45 years) and balanced between males (n=187) and females (n=204). 356 (91%) of 391 cases had mild or moderate clinical severity at initial assessment. […] Cases were isolated on average 4·6 days (95% CI 4·1-5·0) after developing symptoms; contact tracing reduced this by 1·9 days (95% CI 1·1-2·7). […] Moreover, children are at a similar risk of infection to the general population, although less likely to have severe symptoms; hence they should be considered in analyses of transmission and control. | 2020-05-05 |
| 32353398 | While elderly patients are at high risk of fatality, research concerning COVID-19 has largely been done on clarifying the clinical features. […] Given that single-centre studies are less likely informative as elderly remains a minority in the total Chinese population, the present study reviewed the clinical data of geriatric COVID-19 patients gathered from different sources in the public domain. | 2020-05-29 |
| 32353441 | Several studies have been published describing the clinical and radiographic findings on the novel coronavirus (COVID-19) pneumonia. | 2020-05-02 |
| 32353518 | Seventy-six psychiatric patients and 109 healthy control subjects were recruited from Chongqing, China and completed a survey on demographic data, physical symptoms during the past 14 days and a range of psychiatric symptoms using the Impact of Event Scale-Revised (IES-R), Depression, Anxiety and Stress Scale (DASS-21) and Insomnia Severity Index (ISI). […] IES-R measures PTSD symptoms in survivorship after an event. | 2020-05-03 |
| 32353549 | This study aimed to compare clinical courses and outcomes between pregnant and reproductive-aged non-pregnant women with COVID-19, and to assess the vertical transmission potential of COVID-19 in pregnancy. […] Medical records of pregnant and reproductive-aged non-pregnant women hospitalized with COVID-19 from January 15 to March 15, 2020 were retrospectively reviewed. […] Pregnant women have comparable clinical courses and outcomes with reproductive-aged non-pregnant women when infected with SARS-CoV-2. | 2020-05-29 |
| 32353740 | Although some people infected with SARS CoV-2 have no symptoms, the spectrum of symptomatic infection ranges from mild to critical, with most COVID-19 infections being not severe. […] The common mild symptoms include body aches, dry cough, fatigue, low-grade fever, nasal congestion, and sore throat. […] More severe COVID-19 symptoms are typical of pneumonia, and upon progression, the patient’s condition can worsen with severe respiratory and cardiac problems. | 2020-05-18 |
| 32353760 | The Panther Fusion SARS-CoV-2 assay and the SHC LDT perform similarly on clinical nasopharyngeal swab specimens. | 2020-05-27 |
| 32353857 | Diagnostic testing is critical for epidemiological surveillance, but the accuracy (sensitivity and specificity) and clinical utility (impact on health outcomes) of the current diagnostic methods used for SARS-CoV-2 detection are not known. […] I did not find any papers that report on the clinical utility of the tests currently used for COVID-19 detection, meaning that we are fighting a battle without proper knowledge of the proportion of false negatives that current testing is resulting in. | 2020-05-04 |
| 32353859 | There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. […] Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). | 2020-05-30 |
| 32353898 | The clinical features of COVID-19 range from a mild illness to patients with a very severe illness with acute hypoxemic respiratory failure requiring ventilation and Intensive Care Unit admission. […] Little is known about the mechanisms behind observed episodes of sudden deterioration or the infrequent idiosyncratic clinical demise in otherwise healthy and young subjects. […] As in other diseases, the answer to some of these questions may in time be provided by genotyping as well careful clinical, serological, radiological and histopathological phenotyping, which enable mechanistic insights into the differences in pathogenesis and underlying immunological and tissue regenerative response patterns. | 2020-04-30 |
| 32353982 | In the current work, we analyzed and elucidated the two main elements that should be taken into account to understand the “ocular route”, both from a clinical and molecular point of view. | 2020-05-01 |
| 32353991 | We estimated the early transmissibility via time-varying reproduction number based on the Bayesian method that incorporates uncertainty in the distribution of serial interval (time interval between symptoms onset in an infected individual and the infector), and adjusted for disease importation. | 2020-05-06 |
| 32354081 | Moreover, it has been reported that infected subjects, both with and without clinical signs of COVID-19, can transmit the virus. […] This protocol should be implemented by modifying both patient management and clinical practice, introducing particular devices and organizational practices. | 2020-05-08 |
| 32354181 | High-impact articles covered fields of basic science and clinical medicine. | 2020-05-06 |
| 32354293 | Fever (87.5%) and cough (53.8%) were the most commonly reported symptoms, followed by fatigue (22.5%), diarrhea (8.8%), dyspnea (11.3%), sore throat (7.5%), and myalgia (16.3%). […] There are reports of neonatal infection, but no direct evidence of intrauterine vertical transmission has been found.Conclusions: The clinical characteristics of pregnant women with COVID-19 are similar to those of non-pregnant adults. | 2020-05-01 |
| 32354360 | Information on the clinical course and prognosis of COVID-19 was not thoroughly described. […] We described the clinical courses and prognosis in COVID-19 patients. […] Epidemiological, demographic, and clinical data were collected. […] The clinical course of survivors and non-survivors were compared. […] The clinical course of COVID-19 presented as a tri-phasic pattern. […] During week 2, in mild cases, fever, cough, and systemic symptoms began to resolve and platelet count rose to normal range, but lymphopenia persisted. | 2020-05-04 |
| 32354631 | The purpose of this study was to report the clinical evaluation of a 3D-printed protective face shield designed to protect interventional radiologists from droplet transmission of the SARS-Cov-2. | 2020-05-03 |
| 32354634 | These preliminary findings describe a rapid clinical deterioration associated with chest radiographic deterioration and escalating oxygen requirement in renal transplant recipients with SARS-Cov2 pneumonia. | 2020-05-27 |
| 32354637 | All patients displayed respiratory symptoms and fever. […] Other common clinical features included hypoxia, chest crepitation, lymphopenia and high C-reactive protein. […] The symptoms are predominantly respiratory and associated with fever. | 2020-05-28 |
| 32354653 | The aim of this project was to evaluate which personal protective equipment (PPE) eye care practitioners (ECP) will use during the next months and also what they will ask the patient to use in clinical practice. | 2020-05-27 |
| 32354770 | We present two patients with covid-19 and concurrent neurological symptoms. […] Our first patient is a 31-year-old man who had flu-like symptoms due to covid-19 and later developed an acute-onset severe headache and loss of consciousness and was diagnosed with a Hunt and Hess grade 3 subarachnoid haemorrhage from a ruptured aneurysm. | 2020-05-01 |
| 32354798 | We sought to explore the prevalence and immediate clinical implications of acute myocardial injury in a cohort of patients with covid-19 in a region of China where medical resources are less stressed than in Wuhan (the epicentre of the pandemic). | 2020-05-01 |
| 32354990 | Data regarding age, sex, IBD (type, treatments and clinical activity), other comorbidities (Charlson Comorbidity Index (CCI)), signs and symptoms of COVID-19 and therapies were compared with COVID-19 outcomes (pneumonia, hospitalisation, respiratory therapy and death). | 2020-05-28 |
| 32355099 | Secondary to policies enacted by the New York State government to limit spread of the virus, Orthopedic Surgery departments at hospitals around the area have witnessed an abrupt change in clinical demands. […] At a local level one trauma hospital in Queens, New York, Orthopedic Surgery elective cases have been cancelled, trauma consult volume has experienced a sharp decline, and both residents and attendings have been repurposed to meet the new clinical demands of this medical crisis. […] We prepared this primer to make our experience with caring for COVID-19 patents available as a reference for other surgical subspecialty services preparing to adjust the clinical focus of their hospital teams during this or future pandemics. | 2020-05-16 |
| 32355546 | To evaluate the diagnostic performance and clinical utility of the colloidal gold immunochromatography assay for SARS-Cov-2 specific IgM/IgG anti-body detection in suspected COVID-19 cases. […] In the prospective cohort, 150 patients with fever or respiratory symptoms were enrolled in Taizhou Public Health Medical Center, Taizhou Hospital, Zhejiang province, China, between January 20 to February 2, 2020. […] Subgroup analysis were performed with respect to age, sex, period from symptom onset and clinical severity. […] In subgroup analysis, the sensitivity was significantly higher in patients with symptoms more than 14 days 95.2% [95% CI 0.741-0.998] and patients with severe clinical condition 86.0% [95% CI 0.640-0.970]. […] Further investigations should be done to evaluate this assay in variety of clinical settings and populations. | 2020-05-03 |
| 32355564 | Dornase alfa should be considered for clinical trials in treatment of severe COVID-19. | 2020-05-21 |
| 32355889 | We aimed to survey gastroenterologists worldwide using Twitter to help elucidate these definitions using commonly encountered clinical scenarios during the COVID-19 pandemic. Methods A 16-question survey was designed by the authors to include common clinical scenarios that do not have clear guidelines regarding the timing or urgency of endoscopic evaluation. | 2020-05-05 |
| 32356025 | These findings should be carefully interpreted in light of the clinical context of the patient and could prompt a pharyngeal swab PCR test to rule out the possibility of SARS-CoV-2 infection in asymptomatic patients. | 2020-05-29 |
| 32356569 | The unprecedented challenges posed by the coronavirus disease 2019 (COVID-19) pandemic highlight the urgency for applying clinical pharmacology and model-informed drug development in (i) dosage optimization for COVID-19 therapies, (ii) approaching therapeutic dilemmas in clinical trial settings, and (iii) maximizing value of information from impacted non-COVID-19 trials. […] More than ever, we have a responsibility for adaptive evidence synthesis with a Totality of Evidence mindset in this race against time across biomedical research, clinical practice, drug development, and regulation. | 2020-05-29 |
| 32356583 | This manuscript summarizes the common themes of the podcast which centered around three main topics: more benign clinical disease and progression in pediatric cases compared to adults, a strong need for strategies to protect health care workers, and social or economic disparities as a barrier to successful pandemic control. | 2020-05-01 |
| 32356626 | Concern has been aroused regarding a potential harmful effect of angiotensin-converting-enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) in this clinical context. […] Our results did not confirm previous concerns regarding a potential harmful association of ACE inhibitors or ARBs with in-hospital death in this clinical context. | 2020-05-09 |
| 32356627 | Information about the use of selected drugs and patients’ clinical profiles was obtained from regional databases of health care use. […] The use of ACE inhibitors and ARBs was more common among case patients than among controls, as was the use of other antihypertensive and non-antihypertensive drugs, and case patients had a worse clinical profile. | 2020-05-09 |
| 32356641 | However, in a significant proportion of patients, there are no clinical manifestations of the disease, and symptoms may be very mild or atypical. […] There is a growing body of evidence that digestive manifestations of COVID‑19 are frequently reported and may precede typical respiratory symptoms. […] These data suggest that gastrointestinal symptoms in COVID‑19 are not accidental findings and they may result from direct digestive involvement. | 2020-05-29 |
| 32356761 | We hereby review the clinical insights with regard to using molecular tests and immunoassays in the context of COVID-19 management life cycle: the preventive phase, the preparedness phase, the response phase and the recovery phase. […] Clinical needs are discussed to identify existing technology gaps in these tests. | 2020-05-04 |
| 32356863 | This was a cohort study performed at an academic tertiary care center in Boston, Massachusetts, of patients hospitalized with at least 1 positive COVID-19 nasopharyngeal polymerase chain reaction test result and clinical findings consistent with pneumonia who received at least 1 day of hydroxychloroquine from March 1, 2020, through April 7, 2020. | 2020-05-06 |
| 32356867 | During the quarantine period, any relevant symptoms (fever, cough, or other respiratory symptoms) of contacts triggered a COVID-19 test. […] Secondary clinical attack rate (considering symptomatic cases only) for different exposure time windows of the index cases and for different exposure settings (such as household, family, and health care). […] The overall secondary clinical attack rate was 0.7% (95% CI, 0.4%-1.0%). | 2020-05-06 |
| 32356900 | This statement was planned on 11 March 2020 to provide clinical guidance and aid staff preparation for the coronavirus disease 2019 (COVID-19) pandemic in Australia and New Zealand. | 2020-05-31 |
| 32356910 | The main findings from available data are as follows: (a) Convalescent plasma may reduce mortality in critically ill patients, (b) Increase in neutralizing antibody titers and disappearance of SARS-CoV-2 RNA was observed in almost all the patients after CPT therapy, and (c) Beneficial effect on clinical symptoms after administration of convalescent plasma. […] Well-designed large multicenter clinical trial studies should be conducted urgently to establish the efficacy of CPT to COVID-19 patients. | 2020-05-13 |
| 32356926 | In this commentary article, the authors make the case for the election of telmisartan as such alternative on the basis of its pharmacokinetic and pharmacodynamic properties and present an open-label randomized phase II clinical trial for the evaluation of telmisartan in COVID-19 patients (NCT04355936). | 2020-05-05 |
| 32357072 | We aimed to further clarify the clinical characteristics of diabetes with COVID-19. Methods: Twenty-eight patients with diabetes and COVID-19 were enrolled from January 29, 2020, to February 10, 2020, with a final follow-up on February 22, 2020. […] Epidemiologic, demographic, clinical, laboratory, treatment, and outcome data were analyzed. Results: The average age of the 28 patients was 68.6 ± 9.0 years. […] Fever (92.9%), dry cough (82.1%), and fatigue (64.3%) were the most common symptoms, followed by dyspnea (57.1%), anorexia (57.1%), diarrhea (42.9%), expectoration (25.0%), and nausea (21.4%). | 2020-05-01 |
| 32357074 | Based on preliminary clinical reports, hypoxic respiratory failure complicated by acute respiratory distress syndrome is the leading cause of death. […] We review the rapidly changing epidemiology, pathophysiology, emerging therapy, and clinical outcomes of coronavirus disease 2019; and based on these data and previous experience with artificial cardiopulmonary support strategies, particularly in the setting of infectious diseases, provide consensus recommendations from American Society for Artificial Internal Organs. | 2020-05-05 |
| 32357086 | Objective: To analyze the application of Kirkpatrick’s model in the nurse training program among the emergency surgery department based on clinical demand during the COVID-19 (coronavirus disease-2019). […] To provide reference for the training of emergency surgical nurses during the outbreak of COVID-19. Design: Guided by Kirkpatrick’s model, 35 nurses in the emergency surgery department were trained according to a program that resulted from the clinical demand during the pandemic. […] At learning level, the differences between theoretical and operational scores of tested nurses before and after training proved to be statistically significant (p < 0.001). Conclusion: The application of Kirkpatrick’s model based on clinical demand during the COVID-19 confirms to be effective for the training program of nurses in the emergency surgery department. […] It is also beneficial to improve nurses’ knowledge and skills during the pandemic, which serves as a positive influence for clinical reference. | 2020-05-01 |
| 32357257 | This review discusses respirators, their purpose, types, clinical efficiency and proper donning and doffing techniques. | 2020-05-29 |
| 32357275 | We retrospectively analyzed the clinical data of outpatients and inpatients in the department of kidney transplantation from January 20 to March 1, 2020, and followed up the in-home kidney transplant recipients and those waiting for kidney transplantation through the Internet platform. | 2020-05-27 |
| 32357503 | Due to the scientific community’s efforts, there is an increasing body of published studies describing the virus’ biology, its transmission and diagnosis, its clinical features, its radiological findings, and the development of candidate therapeutics and vaccines. […] Defining the pathophysiology of death is not only limited to forensic considerations; it may also provide useful clinical and epidemiologic insights. […] Only by working with a complete set of histological samples obtained through autopsy can one ascertain the exact cause(s) of death, optimize clinical management, and assist clinicians in pointing out a timely and effective treatment to reduce mortality. | 2020-05-04 |
| 32357575 | The clinical complexity associated with the management of frailty may increase the risk of complications during infection as well as the lack of the early recognition of atypical symptoms. […] There is an urgent need to share expertise and clinical management skills with geriatricians as well as the need for early diagnosis to start treatment at the earliest convenience in the community, with the aim to avoid the collapse of intensive care units. | 2020-05-04 |
| 32358044 | We also made necessary changes to clinical practices and enforced strict infection control measures. | 2020-05-02 |
| 32358202 | However, clinical evidence suggests that the intestine may present another viral target organ. | 2020-05-07 |
| 32358217 | Telemedicine has rapidly moved to the frontline of clinical practice due to the need for prevention and mitigation strategies; these have been encouraged, facilitated, and enabled by changes in government rules and regulations and payer-driven reimbursement policies. | 2020-05-28 |
| 32358230 | Clinical practice modifications are recommended during the pandemic, in outpatient and perioperative settings. | 2020-05-15 |
| 32358232 | Based on preliminary clinical reports, hypoxic respiratory failure complicated by acute respiratory distress syndrome is the leading cause of death. […] We review the rapidly changing epidemiology, pathophysiology, emerging therapy, and clinical outcomes of COVID-19; and based on these data and previous experience with artificial cardiopulmonary support strategies, particularly in the setting of infectious diseases, provide consensus recommendations from ASAIO. | 2020-05-30 |
| 32358833 | We assess the scope for targetting key host and viral targets in the mid-term, by first screening these targets against drugs already licensed; an agenda for drug re-purposing, which should allow rapid translation to clinical trials. | 2020-05-08 |
| 32358954 | Articles presenting clinical data for patients with coronavirus infection (defined as SARS-1, MERS, SARS-COV-2, and other coronavirus) and bacterial/fungal co-infection reported in English, Mandarin, or Italian were included. | 2020-05-06 |
| 32358956 | Antibody assay was conducted to detect COVID-19 envelope protein E and nucleocapsid protein N antigen. 112 patients were recruited with symptoms of fever, cough, fatigue, myalgia, and diarrhoea. | 2020-05-06 |
| 32358960 | As it uses the standard protocols, reagents and equipment, this pooling method can be applied immediately in current clinical testing laboratories. | 2020-05-06 |
| 32359035 | Clinical and laboratory parameters were prospectively collected at baseline, day 1, 2, 7 and 14. | 2020-05-29 |
| 32359101 | Through our hypothesis, we make the prediction that the FDA-approved molecule, icatibant, might be able to interrupt this feedback loop and, thereby, improve the clinical outcomes. […] This hypothesis could lead to basic, translational, and clinical studies aimed at reducing COVID-19 morbidity and mortality. | 2020-05-02 |
| 32359177 | To reveal the hepatic injury related to this disease and its clinical significance, we conducted a multicenter retrospective cohort study that included 5,771 adult patients with COVID-19 pneumonia in Hubei Province. | 2020-05-02 |
| 32359203 | In this study, the literature currently available on CQ and HCQ as treatment of COVID-19 was surveyed using EMBASE, PubMed, Cochrane Library, MedRxiv, and one clinical trial registry. […] There are currently seven completed clinical trials and 29 registered clinical trials focusing on HCQ or CQ as a therapeutic avenue for COVID-19. […] There are several clinical trials currently under way with results expected soon. | 2020-05-29 |
| 32359205 | To report the clinical characteristics, including gastrointestinal symptoms, of COVID-19 in IBD patients, and to assess the risk of COVID-19 in IBD. | 2020-05-02 |
| 32359210 | After initial flulike symptoms, progression to an inflammatory phase may occur, characterized by cytokine release rapidly leading to respiratory and multiorgan failure. […] We report the clinical course and management of a liver transplant recipient on hemodialysis, who presented with COVID-19 pneumonia, and despite completing a 5-day course of hydroxychloroquine, later developed marked inflammatory manifestations with rapid improvement after administration of off-label, single-dose tocilizumab. | 2020-05-02 |
| 32359479 | With no antiviral drugs nor vaccines, and the presence of carriers without obvious symptoms, traditional public health intervention measures are significantly less effective. | 2020-05-05 |
| 32359788 | Specifically, it has been used in the treatment of many viral infections with varying degrees of clinical efficacy. […] The concluding sections of this review address the potential use of convalescent plasma during the present-day SARS-CoV-2 pandemic, not only insofar as its clinical benefit but also the steps required to make convalescent plasma treatments readily available for an exponentially growing patient population. | 2020-05-05 |
| 32359937 | The purpose of this study was to highlight the importance of timely brachytherapy treatment for patients with gynecologic, breast, and prostate malignancies, and provide a framework for brachytherapy clinical practice and management in response to the COVID-19 pandemic. | 2020-05-06 |
| 32359943 | We prospectively collected medical records of 14 health care workers (HCWs) who were infected with SARS-CoV-2, in neurosurgery department of Wuhan Union Hospital, China. […] The main symptoms included myalgia or fatigue (100%), fever (86%) and dry cough (71%). | 2020-05-25 |
| 32360053 | A great percentage of patients with this disease developed symptoms of dry cough, malaise, and a high fever. | 2020-05-26 |
| 32360126 | Respiratory illness is the major cause of morbidity and mortality in these patients with the disease spectrum ranging from asymptomatic subclinical infection, to severe pneumonia progressing to acute respiratory distress syndrome. […] Patients with cardiovascular disease are more likely to be infected with SARS-CoV-2 and they are more likely to develop severe symptoms. | 2020-05-26 |
| 32360133 | It is unclear whether a more aggressive clinical course might develop in asymptomatic COVID-19 infected subjects during biological therapy and current evidence does not support treatment suspension. […] When clinical conditions and the disease activity do not allow a treatment delay, before starting a biological therapy, screening of IBD patients for COVID-19 active infection by RT-PCR should be advisable, even in absence of clinical suspicion. | 2020-05-06 |
| 32360205 | The symptoms associated with COVID-19 are mainly characterized by a triad composed of fever, dry cough and dyspnea. […] However, digestive symptoms have also been reported. […] The symptoms mainly include anorexia, diarrhea, nausea and/or vomiting and abdominal pain. […] Even though prognosis is associated with lung injury, digestive symptoms seem significantly more frequent in patients presenting with severe COVID-19 infection. […] Digestive presentations, which may be isolated or which can precede pulmonary symptoms, have indeed been reported, with diarrhea as a leading clinical sign. […] No data exist on the value of digestive endoscopy in cases of persistent digestive symptoms. […] Fecal-oral transmission of the infection is possible, especially insofar as viral shedding in stools seems frequent and of longer duration than at the ENT level, including in patients with negative throat swab and without digestive symptoms. | 2020-05-05 |
| 32360286 | Forty-eight cytokines in the plasma samples from 50 COVID-19 cases including 11 critically ill, 25 severe and 14 moderate patients were measured and analyzed in combination with clinical data. | 2020-05-03 |
| 32360301 | Herein, we propose that by incorporating readily available point-of-care tests and conducting accurate clinical risk assessments, a safe and timely return to elective endoscopy is feasible. | 2020-05-30 |
| 32360420 | Clinical intervention in patients with corona virus disease 2019 (COVID-19) has demonstrated a strong upregulation of cytokine production in patients who are critically ill with SARS-CoV2-induced pneumonia. […] In a retrospective study of 41 patients with COVID-19, most patients with SARS-CoV-2 infection developed mild symptoms, whereas some patients later developed aggravated disease symptoms, and eventually passed away because of multiple organ dysfunction syndrome (MODS), as a consequence of a severe cytokine storm. | 2020-05-13 |
| 32360439 | Most patients with COVID-19 present with constitutional and respiratory symptoms, some patients present with atypical symptoms including gastrointestinal, cardiovascular, or neurological symptoms. […] We elucidate the clinical characteristics, imaging findings, and the clinical course. | 2020-05-06 |
| 32360444 | To narratively summarize the available literature on the management of COVID-19 in order to combine current evidence and frontline opinions and to provide balanced answers to pressing clinical questions. […] The available literature and the authors’ frontline-based opinion are summarized in brief narrative answers to selected clinical questions, with a conclusive statement provided for each answer. […] Physicians must be aware that, as they are not supported by high-level evidence, these treatments may often be ethically justifiable only in those worsening patients unlikely to improve only with supportive care, and who cannot be enrolled onto randomized clinical trials. | 2020-05-18 |
| 32360481 | However, the clinical characteristics of patients in other areas around Wuhan, Hubei Province are still unclear. […] In this study, we performed epidemiological and clinical characteristics analysis on these regional cases. […] Their epidemiological, clinical manifestations, and imaging characteristics were analysed. […] Among the 73 patients studied, 12.3 % developed symptoms after returning to Shiyan from Wuhan, and 71.2 % had a history of close contact with Wuhan personnel or confirmed cases. […] The first main symptoms presented by these patients were fever (84.9 %) and cough (21.9 %). […] The longest incubation period was 26 days, and the median interval from the first symptoms to admission was 5 days. […] Multivariate regression analysis should be used to further guide the allocation of clinical resources. | 2020-05-30 |
| 32360482 | The French Minister of Health, who has raised an alarm on a possible risk deriving from the use of ibuprofen for the control of fever and other symptoms during the disease, opened the debate a few days ago. […] In this paper we examine available evidence from preclinical and clinical studies that had analysed the role of COX in the inflammatory process and the effects of NSAIDs in patients with infections. […] Since nowadays no scientific evidence establishes a correlation between NSAIDS and worsening of COVID-19, patients should be advice against any NSAIDs self-medication when COVID-19 like symptoms are present. | 2020-05-30 |
| 32360500 | They have published a great amount of first-hand clinical data. […] These presentations are the clinical features of COVID-19 in children. | 2020-05-07 |
| 32360516 | Acute respiratory distress syndrome (ARDS) is a devastating clinical manifestation of COVID-19 pneumonia and is mainly based on an immune-driven pathology. […] While a “cytokine storm” involving IL-6 and other cytokines has been documented, complement C3 activation has been implicated as an initial effector mechanism that exacerbates lung injury in preclinical models of SARS-CoV infection. […] Herein, we report the clinical course of a patient with severe ARDS due to COVID-19 pneumonia who was safely and successfully treated with the compstatin-based complement C3 inhibitor AMY-101. | 2020-05-31 |
| 32360578 | The order of treatments may be on the basis of patient factors and clinical resources. […] For patients who are confirmed to have COVID-19, usually, cancer therapies may be withheld until symptoms have resolved with negative viral test results. | 2020-05-19 |
| 32360581 | Azithromycin has been shown to have a clinical efficacy against severe acute respiratory syndrome coronavirus 2; ivermectin has also demonstrated a remarkable experimental efficacy with a potential to be used for Coronavirus disease 2019. […] Further, BCG vaccination is being considered for clinical trials aiming to test its potential for lowering COVID-19 morbidity and mortality. […] The author also recommends testing their combined administration as early during the clinical course of COVID-19 as possible. | 2020-05-30 |
| 32360583 | The primary outcomes were mortality, virological eradication and clinical improvement, and secondary outcomes were improvement of symptoms and chest radiography results, incidence of acute respiratory disease syndrome (ARDS), utilization of mechanical ventilation, and adverse events (AEs). […] Compared with control treatment, anti-coronary virus interventions significantly reduced mortality (RR 0.65, 95% CI 0.44-0.96; I2 = 81.3%), remarkably ameliorate clinical improvement (RR 1.52, 95% CI 1.05-2.19) and radiographical improvement (RR 1.62, 95% CI 1.11-2.36, I2 = 11.0 %), without manifesting clear effect on virological eradication, incidence of ARDS, intubation, and AEs. | 2020-05-30 |
| 32360585 | The majority of patients showed nonspecific symptoms such as fever, dry cough, and fatigue. […] Although many clinical trials are already underway and the majority of patients have received antiviral therapy based on medication experience with severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), and preliminary results from some clinical trials, there are no antiviral drugs proven to be effective currently. […] We summarize the current therapeutic medicines used in the clinic, hope to be able to provide some implications for clinical medication. | 2020-05-30 |
| 32360679 | The aim of our study was to determine the incidence, characteristics, and clinical outcomes of patients with the novel coronavirus (COVID-19) infection who had presented with and been treated for acute limb ischemia (ALI) during the 2020 coronavirus pandemic. | 2020-05-15 |
| 32360703 | Since the infection starts in the upper respiratory system, first flu-like symptoms develop that spread throughout the body. | 2020-05-31 |
| 32360729 | Here, we report the postmortem lung findings from a 37-year-old man with asthma, who met the clinical criteria for severe acute respiratory distress syndrome and died of COVID-19 less than 2 weeks after presentation to the hospital. | 2020-05-14 |
| 32360780 | Detailed knowledge on the prevalence of asymptomatic cases of coronavirus disease 2019 (COVID-19) and the clinical characteristics of mild COVID-19 is essential for effective control of the COVID-19 pandemic. […] We determined the prevalence of asymptomatic cases of COVID-19 and characterized the symptoms of patients with mild COVID-19. […] Study participants were recruited from a community facility designated for the isolation of patients without moderate-to-severe symptoms of COVID-19 in South Korea. […] The prevalence of asymptomatic patients at admission and the detailed symptoms of mild COVID-19 were evaluated through a questionnaire-based survey. […] Of the 68 individuals with hyposmia, 61 (90%) had accompanying symptoms such as hypogeusia, nasal congestion or rhinorrhoea. […] Social distancing should be strongly implemented to prevent disease transmission from asymptomatic individuals or those with mild and inconspicuous symptoms. | 2020-05-29 |
| 32360909 | Epidemiological, clinical and immunological studies from COVID-19 recovered patients are particularly important to understand the disease and to prepare better for potential outbreaks in the future. | 2020-05-12 |
| 32361028 | We hypothesize that amantadine could decrease the viral load in SARS-CoV-2 positive patients and as such it may serve as a potent therapeutic decreasing the replication and infectivity of the virus likely leading to better clinical outcomes. […] Clinical studies will be needed to examine the therapeutic utility of amantadine in COVID-19 infection. | 2020-05-08 |
| 32361072 | After instituting our new COVID-19 guidelines, our average weekly clinical volume decreased by 96.5% (from 43.1 patients to 1.5 patients per week), our average weekly surgical volume decreased by 71.7% (from 15 cases to 4.25 cases per week), and our inpatient consultation volume decreased to 1.81 consultations daily; 60% of the consultations were completed as telemedicine “e-consults” in which the patient was never evaluated in-person. | 2020-05-25 |
| 32361098 | Clinical studies confirmed that 2019-nCoV and SARS-CoV could be detected in saliva of human patients. | 2020-05-18 |
| 32361152 | ▪▪▪ STUDY DESIGN AND METHODS: A group of approved panelists developed key clinical questions by using the Population, Intervention, Comparator, and Outcome (PICO) format that addressed specific topics on bronchoscopy related to COVID-19 infection and transmission. | 2020-05-29 |
| 32361161 | In this paper, we will systematically review the pathogenic features, transmission routes, and infection mechanisms of SARS-CoV-2, as well as any adverse effects on the digestive system, urogenital system, central nervous system, and circulatory system, in order to provide a theoretical and clinical basis for the diagnosis, classification, treatment, and prognosis assessment of SARS-CoV-2 infection. | 2020-05-21 |
| 32361322 | Of 52 clinical samples collected from 50 persons tested, respiratory viruses were detected in 22 samples (42 %), including SARS CoV-2 (n = 5), rhinovirus (n = 7), enterovirus (n = 5), influenza B (n = 4), hMPV (n = 5), influenza A (n = 2), PIV-2 (n = 1), RSV (n = 2), CoV-NL63 (n = 1) and CoV-229E (n = 1). […] The Ct values of the real-time in-house-developed PCR assay targeting the E gene was significantly lower than the corresponding RdRp gene assay when applied to clinical samples, viral culture and positive controls (mean 21.75 vs 28.1, p = 0.0031). | 2020-05-28 |
| 32361323 | To assess clinical profiles of pediatric COVID-19. […] A retrospective analysis was undertaken using clinical data of sixteen children (11 months-14 years) diagnosed with COVID-19 between January 1, 2020 and March 17, 2020 at Xiangyang Central Hospital, Hubei province, China. | 2020-05-27 |
| 32361324 | The median period between symptoms presence and positive SARS-CoV-2 RT-PCR results was 16 days (IQR, 10-23, N = 301). […] The median period between symptoms presence and an effective negative SARS-CoV-2 RT-PCR result was 20 days (IQR, 17-24; N = 216). | 2020-05-27 |
| 32361327 | A few studies have revealed the clinical characteristics of hospitalized patients with COVID-19. […] Clinical, laboratory, and treatment data were collected and analyzed from 111 hospitalized patients with laboratory-confirmed COVID-19 in Union Hospital. | 2020-05-27 |
| 32361387 | Data were collected from 7,236 participants assessed with anxiety disorders, depressive symptoms, and poor sleep . […] The overall prevalence of anxiety disorders, depressive symptoms, sleep quality were 35.1%, 20.1%, 18.2%, respectively. […] Younger people reported a higher prevalence of anxiety disorders and depressive symptoms than older people (P < 0.001). | 2020-05-29 |
| 32361409 | Clinical manifestations of COVID-19 include diarrhea, pneumonia, lymphopenia, exhausted lymphocytes, and pro-inflammatory cytokine production. […] Immunology is part of the process of clinical evolution, but there are some questions around immunity-based protection: (1) why some infected people have only mild symptoms of the disease or are asymptomatic; (2) why delayed and weak antibody responses are associated with severe outcomes; and (3) why positivity in molecular tests does not represent protective antibody IgG. | 2020-05-27 |
| 32361413 | The objective of this report is to better understand the initial CT imaging spectrum and the relationship between clinical characteristics and initial CT imaging features of an imported family cluster cases involving 7 laboratory-confirmed COVID-19 patients. […] We find that initial CT findings of 4 patients were positive within one week after the onset of symptoms and 1 patient was negative before the onset of symptoms. | 2020-05-29 |
| 32361455 | Clinical and epidemiological evidence has been advanced for human-to-human transmission of the novel coronavirus rampaging the world since late 2019. | 2020-05-12 |
| 32361529 | We hope that this strategy could be applied rapidly, and confirmed for viability with clinical samples, before being rolled out for mass-diagnostic testing in these current times. | 2020-05-12 |
| 32361535 | The purpose of this case report is to describe the radiographic and clinical features of a COVID-19 pneumonia patient without clear epidemiological history outside Wuhan, China. | 2020-05-29 |
| 32361701 | Suspicious cases included patients with a history of dry cough, chills or sore throat accompanying by shortness of breath with or without fever, patients with upper/lower respiratory symptoms with radiological manifestations as single or double-sided multilobular infiltrations on CT scan or plain chest radiography, any one that has a history of close contact with a definite COVID-19 case within the last 14 days, any one with a history of presence in COVID-19 epidemic regions within the last 14 days and patient with pneumonia that despite of proper treatment has an inappropriate clinical response and clinical condition becomes more severe in an unusual way or unexpectedly. | 2020-05-06 |
| 32361703 | He was discharged healthy without development of new pulmonary symptoms despite immunosuppressive treatment. | 2020-05-06 |
| 32361714 | The common clinical symptoms of the highly pathogenic and large-scale epidemic virus include fever, cough, fatigue, ageusia and anosmia and in some patients, gastrointestinal infection symptoms. […] Under these circumstances, it is critical for health care settings, including nuclear medicine departments to take infection control measures, to prevent a potential spread not just among patients but also to staff members as well as to reconsider the performance of randomized clinical trials. […] Hellenic Journal of Nuclear Medicine will remain true to the set principles, values and past and prepared to cope with future challenges in the scientific and clinical setting. | 2020-05-05 |
| 32361715 | For his experiment Galen used the random allocation of treatment, today’s prospective randomised clinical trial, implemented in the evaluation of novel therapies, widely used internationally, particularly in cancer research! […] According to the Declaration of Helsinki participation of a subject in a clinical trial requires their explicit written consent. […] Perhaps human ingenuity will seek new investigative methods that will render the randomised clinical trial obsolete, both, on methodological and ethical grounds. | 2020-05-05 |
| 32361723 | We selected baseline clinical and laboratory data through the stepwise Akaike information criterion and ensemble XGBoost model to build mortality-prediction models. […] The clinical model developed with age, history of hypertension and coronary heart disease showed AUC of 0.88 (95% CI, 0.80-0.95); threshold, -2.6551; sensitivity, 92.31%; specificity, 77.44% and negative predictive value (NPV), 99.34%. […] The laboratory model developed with age, high-sensitivity C-reactive protein (hsCRP), peripheral capillary oxygen saturation (SpO2), neutrophil and lymphocyte count, D-dimer, aspartate aminotransferase (AST) and glomerular filtration rate (GFR) had a significantly stronger discriminatory power than the clinical model (p=0.0157), with AUC of 0.98 (95% CI, 0.92-0.99); threshold, -2.998; sensitivity, 100.00%; specificity, 92.82% and NPV, 100.00%. […] In the subsequent validation cohort (N=44), the AUCs (95% CI) were 0.83 (0.68, 0.93) and 0.88 (0.75, 0.96) for clinical model and laboratory model, respectively. | 2020-05-06 |
| 32361738 | Data are urgently needed about risk factors associated with clinical outcomes. […] Patients were classified into three disease severity groups (non-severe, severe, and critical), based on initial clinical presentation. […] Clinical outcomes were designated as favorable and unfavorable, based on disease progression and response to treatments. […] Logistic regression models were performed to identify risk factors associated with clinical outcomes, and log-rank test was conducted for the association with clinical progression. […] By univariate logistic regression analysis, 27 risk factors were significantly associated with clinical outcomes. […] Multivariate regression indicated age over 65 years (p<0.001), smoking (p=0.001), critical disease status (p=0.002), diabetes (p=0.025), high hypersensitive troponin I (>0.04 pg/mL, p=0.02), leukocytosis (>10 x 109/L, p<0.001) and neutrophilia (>75 x 109/L, p<0.001) predicted unfavorable clinical outcomes. […] We also found novel risk factors, such as higher hypersensitive troponin I, predicted poor clinical outcomes. […] Overall, our study provides useful data to guide early clinical decision making to reduce mortality and improve clinical outcomes of COVID-19. | 2020-05-06 |
| 32361744 | This method represents a useful tool for studying remdesivir and GS-441524 clinical pharmacokinetics, particularly during the current COVID-19 outbreak. | 2020-05-06 |
| 32361996 | In asymptomatic patients as well as patients with flu-like symptoms and fever, no SARS-CoV-2 RNA could be detected in the blood or serum despite a clearly positive result in all throat swabs. […] As patients with symptoms of infectious disease will not be admitted to blood donation, the risk for transfusion transmission of SARS-CoV-2 seems to be negligible. | 2020-05-27 |
| 32362005 | Bioinformatics techniques such as artificial intelligence should be used for collecting the hemogram and serum biochemistry data of all COVID-19- infected people worldwide, even they do not show severe symptoms. | 2020-05-21 |
| 32362061 | In particular, there are no current clinical data about the interference exerted by dupilumab, a biologic drugs blocking IL-4 and IL-13, used for adult atopic dermatitis. […] Indeed, viral infections, including respiratory infections, have not been reported as a significant adverse event in clinical trials. | 2020-05-21 |
| 32362062 | This unprecedented virus has caused global pandemic and over 2,300,000 cases worldwide in total number(2), which has been bringing tremendous pressure and challenges to medical institutions and clinical staff around the world. 2019-nCoV can be transmitted by droplets primarily, while it has been reported that surface contact transmission exists as well(3). […] It is of prime importance to ensure and maintain the skin clean, sterilized and protected of clinical health care staff during the fight against the epidemic. | 2020-05-03 |
| 32362104 | The COVID-19 pandemic has changed the Australian medical landscape, especially in relation to how we need to provide clinical care in general practice. | 2020-05-04 |
| 32362193 | Whether asymptomatic patients are contagious or not and whether they need medication are the arguments among clinical experts.Areas covered: This paper reports a special asymptomatic couple with COVID-19, of which the male patient is an intercity bus driver but has not induced confirmed infection of his 188 passengers. […] Their clinical characteristics and medication were summarized and analyzed.Expert opinion: The two asymptomatic patients far away from Wuhan did not seem to be highly contagious. | 2020-05-14 |
| 32362243 | However, further validation and investigation of these inhibitors against SARS-CoV-2 main protease are needed to claim their candidacy for clinical trials. | 2020-05-20 |
| 32362244 | The document includes practice implications for evaluation of stroke patients with caution for stroke team members to avoid COVID-19 exposure, during clinical evaluation and performance of imaging and laboratory procedures with special considerations of intravenous thrombolysis and mechanical thrombectomy in stroke patients with suspected or confirmed COVID-19 infection. | 2020-05-04 |
| 32362245 | Currently, several clinical trials are underway to identify specific drugs for the treatment of this novel virus. […] As this study is based on molecular docking, hence being particular about the results obtained, requires extensive wet-lab experimentation and clinical trials under in vitro as well as in vivo conditions.Communicated by Ramaswamy H. | 2020-05-20 |
| 32362295 | COVID-19 presents new challenges for psychiatry as clinical management, ethical dilemmas and administrative complications need to be addressed. | 2020-05-30 |
| 32362299 | Here, we discuss five considerations arising from our clinical experience and pharmacological background knowledge to enable safe and well-informed psychopharmacotherapy during the COVID-19 pandemic. | 2020-05-28 |
| 32362344 | The purpose of this study was to determine the risk factors associated with pneumonia, acute respiratory distress syndrome (ARDS), and clinical outcome among patients with novel coronavirus disease 2019 (COVID-19). […] This was a cross-sectional multicenter clinical study. […] Clinical, laboratory, and radiologic results, as well as treatment outcome data, were obtained. | 2020-05-06 |
| 32362384 | The objective of this document is to compile these experiences, based on recommendations from official agencies, in a document offering guidance in daily clinical practice. | 2020-05-16 |
| 32362392 | The epidemiologic and clinical characteristics of heart transplant (HTx) recipients during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic remains unclear. | 2020-05-07 |
| 32362504 | The analysis of real-life data from hospital information systems could make possible to decide on the efficacy and safety of Covid-19 treatments by avoiding the pitfalls of preliminary studies and randomized clinical trials. […] The different drugs tested in current clinical trials are already widely prescribed to patients by doctors in hospitals, and can therefore be immediately analysed according to validated methodological standards. | 2020-05-06 |
| 32362505 | Also, knowledge about specific characteristics of respirators is of utmost importance to select the proper type according to the clinical setting. […] Clinical evidence on the use of respirators is poor and interest in the topic has not been constant over time. […] A better understanding of SARS-CoV-2 transmission is needed, together with high-quality clinical data on the use of respirators or alternative devices. | 2020-05-06 |
| 32362564 | In Otorhinolaryngology - Head and Neck Surgery, clinical examination and invasive procedures on the respiratory tract and on airway-connected cavities, such as paranasal sinuses and the middle ear, expose people to direct transmission of SARS-CoV-2 by inhalation or ocular projection of contaminated droplets, and to indirect transmission by contact with contaminated hands, objects or surfaces. | 2020-05-22 |
| 32362644 | Patients will be monitored to document clinical (hospital length of stay and mortality at 14, 28 and 90 days), laboratory (presence of viral RNA in serial throat swab samples) and safety (adverse events and serious adverse events) outcomes. […] Treatment outcomes amongst initial cases would be useful in providing guidance about the clinical management of patients with COVID-19. | 2020-05-06 |
| 32362645 | It was assumed that symptomatic quarantine would identify and quarantine 50 per cent of symptomatic individuals within three days of developing symptoms. […] Port-of-entry-based entry screening of travellers with suggestive clinical features and from COVID-19-affected countries, would achieve modest delays in the introduction of the virus into the community. | 2020-05-06 |
| 32362732 | Although it mainly causes respiratory symptoms, respiratory failure and death due to multiorgan failure, there is evolving evidence to suggest gastrointestinal (GI) and liver involvement by this virus. | 2020-05-21 |
| 32362735 | At the end of December 2019, a novel strain of coronavirus, given the name of 2019-nCoV, emerged for exhibiting symptoms of severe acute respiratory syndrome. | 2020-05-07 |
| 32362969 | The main aim of this systematic review is to provide a comprehensive clinical summary of all the available data from high-quality research articles relevant to the epidemiology, demographics, trends in hospitalization and outcomes, clinical signs and symptoms, diagnostic methods and treatment methods of COVID-19, thus increasing awareness in health care providers. | 2020-05-07 |
| 32363045 | Based on the current epidemic situation, this study reviewed publications on this virus and coronavirus disease 2019 (COVID-19), analyzed common features of respiratory viral pneumonias, and presented the currently reported clinical characteristics of COVID-19 in transplant recipients to improve strategies regarding the diagnosis and treatment of COVID-19 in this special population. | 2020-05-07 |
| 32363137 | •There is currently no evidence that ACEI/ARB increase risk for COVID-19 infection from clinical trials. | 2020-05-07 |
| 32363205 | We aimed to investigate the epidemiological and clinical features, and medical care-seeking process of patients with the 2019 coronavirus disease (COVID-19) in Wuhan, China, to provide useful information to contain COVID-19 in other places with similar outbreaks of the virus. […] We collected epidemiological and clinical information of patients with COVID-19 admitted to a makeshift Fangcang hospital between 7 and 26 February, 2020. […] After clinical recovery from COVID-19, which took a mean of 21 days from illness onset, there was still a substantial proportion of patients who had persistent SARS-CoV-2 infection. […] Clinical recovery is not an appropriate criterion to release isolated patients and as long as 4 weeks’ isolation for patients with COVID-19 is not enough to prevent the spread of the virus. | 2020-05-07 |
| 32363212 | Hydroxychloroquine and chloroquine have garnered unprecedented attention as potential therapeutic agents against COVID-19 following several small clinical trials, uncontrolled case series, and public figure endorsements. […] Here, we perform a rapid narrative review and discuss the strengths and limitations of existing in vitro and clinical studies. | 2020-05-04 |
| 32363219 | Re-purposing the available protease inhibitor drugs for immediate use in treatment in SARS-CoV-2 infections could improve the currently available clinical management. | 2020-05-07 |
| 32363221 | Fever, cough, respiratory distress with fatigue, diarrhea, nausea and vomiting are common symptoms seen in adults. […] The results of ongoing clinical trials on hydroxychloroquine, azithromycin alone or in combination and a new antiviral agent remdesivir may help to treat some of the infections. […] However the results of clinical trials and incorporation of vaccines in public health programs is a long way to go. | 2020-05-07 |
| 32363222 | Few information on clinical features and immunological profile of COVID-19 in paediatrics. […] The clinical features and treatment outcomes of twelve paediatric patients confirmed as COVID-19 were analyzed. […] Clinically, cough (9/12, 75%) and fever (7/12, 58.3%) were the most common symptoms. […] Children infected with SARS-CoV-2 had different immune profile with higher T cell amount and low inflammatory factors level, which might ascribed to the mild clinical symptom. […] We advise that nucleic acid test or examination of serum IgM/IgG antibodies against SARS-CoV-2 should be taken for children with exposure history regardless of clinical symptom. | 2020-05-07 |
| 32363226 | The clinical classification was light. | 2020-05-04 |
| 32363334 | We identified potential clinical scenarios (cardiac injury, myocardial infarction with and without obstructive coronary artery disease, viral myocarditis, and decompensated heart failure) leading to CS and risk factors for poor/uncertain benefit (age, sepsis, mixed/predominantly vasodilatory shock, prothrombotic state and/or coagulopathy, severe acute respiratory distress syndrome, multi-organ failure or high-risk prognostic scores) specific to using VA-ECMO as BTR in COVID-19 infection. | 2020-05-07 |
| 32363337 | We present a case of rapid clinical decompensation and development of severe Acute Respiratory Distress Syndrome (ARDS) in a woman at 31 weeks’ gestation to highlight these unique considerations and present an algorithmic approach to the disease’s diagnosis and management. | 2020-05-04 |
| 32363349 | Health care providers are facing increased risk of moral distress during the COVID-19 pandemic because of changes in clinical practice and resource allocation procedures. | 2020-05-07 |
| 32363351 | A 58 year old woman was admitted with symptoms of COVID-19. | 2020-05-04 |
| 32363409 | In particular, it has been previously demonstrated, in specific populations, a role of particulate matter in worsening clinical presentation of virus infection in airways. | 2020-05-06 |
| 32363492 | This study sought to assess the prevalence rate and socio-demographic correlates of depressive and anxiety symptoms among Chinese adolescents affected by the outbreak of COVID-19. […] An online survey was used to collect demographic data, assess students’ awareness of COVID-19, and assess depressive and anxiety symptoms with the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder (GAD-7) questionnaire, respectively. […] The prevalence of depressive symptoms, anxiety symptoms, and a combination of depressive and anxiety symptoms was 43.7%, 37.4%, and 31.3%, respectively, among Chinese high school students during the COVID-19 outbreak. […] Multivariable logistic regression analysis revealed that female gender was the higher risk factor for depressive and anxiety symptoms. […] In terms of grades, senior high school was a risk factor for depressive and anxiety symptoms; the higher the grade, the greater the prevalence of depressive and anxiety symptoms. | 2020-05-07 |
| 32363506 | Because of COVID-19 outbreak, regular clinical services for Parkinson’s disease (PD) patients have been suddenly suspended, causing worries, confusion and unexpected needs in such frail population. […] Forty-six percent queried about clinical services; 28% communicated an acute clinical worsening for which a therapeutic change was done in 52% of cases; 17% (those patients with younger age and milder disease) asked about the relationship between PD and COVID-19; 8% informed about an intercurrent event. […] Our analysis suggests that PD patients’ needs during COVID-19 emergency include appropriate and complete information, a timely update on changes in clinical services, and the continuity of care, even in a remote mode. […] By addressing these issues, acute clinical worsening, complications and subsequent therapeutic changes could be prevented. | 2020-05-07 |
| 32363615 | In response to the increased demand to screen patients with symptoms concerning for COVID-19, we created a risk assessment triage process for our internal medicine clinic that utilizes residents’ clinical reasoning skills without direct exposure to high-risk patients. | 2020-05-04 |
| 32363707 | In order to better prevent and treat SARS-CoV-2, this article compares the infectivity, pathogenicity, and related clinical characteristics of the three human pathogenic coronaviruses, SARS-CoV-2, SARS-CoV and MERS-CoV to help us further understand the pathogenic characteristics of novel coronaviruses. | 2020-05-04 |
| 32363809 | The presentation of COVID-19 overlaps with common influenza symptoms. […] There is limited data on whether a specific symptom or collection of symptoms may be useful to predict test positivity. […] Respondents were questioned regarding 10 presenting symptoms, demographic information, comorbidities and COVID-19 test results. […] A model using all 5 diagnostic symptoms had the highest accuracy with a predictive ability of 82% in discriminating between COVID-19 results. […] To maximize sensitivity and maintain fair diagnostic accuracy, a combination of 2 symptoms, change in sense of smell or taste and fever was found to have a sensitivity of 70% and overall discrimination accuracy of 75%. | 2020-05-04 |
| 32363880 | Several clinical trials have already been conducted or are currently ongoing to evaluate the efficacy of such drugs. | 2020-05-29 |
| 32364119 | In view of the magnitude of the epidemic, we conducted a speculative review of possible medium- and long-term neurological consequences of SARS-CoV-2 infection, with particular emphasis on neurodegenerative and neuropsychiatric diseases of neuroinflammatory origin, based on the available evidence on neurological symptoms of acute SARS-CoV-2 infection. | 2020-05-10 |
| 32364126 | Despite a low level of consensus between participants, there was strong (85%) and moderate consensus (70%) about certain subjects, mainly the increase in precautions to be taken, the use of telemedicine and teleconsultations, the reduction of care provided in in-person consultations to avoid the presence of large numbers of people in waiting rooms, the development of remote training solutions, and the changes in monitoring visits during clinical trials. | 2020-05-13 |
| 32364528 | We reviewed the chest CT scans, laboratory findings, and clinical records of 66 COVID-19 patients who were admitted to affiliated hospitals of Nanchang university, Nanchang, China, from Jan 21 to Feb 2, 2020. […] The major symptoms were fever (60/66, 91%) and cough (37/66, 56%). […] Fever and cough are the major symptoms. […] Evaluating chest CT, clinical symptoms, and laboratory results could facilitate the early diagnosis of COVID-19, and judge disease progression. | 2020-05-26 |
| 32364677 | A liver and kidney transplant patient with SARS-CoV-2 pneumonia without respiratory failure was treated in a clinical multimodal strategy consisting of symptomatic support therapy, immunosuppression reduction, use of anti-coronavirus drugs and heparin leading to a progressive improvement of patient symptoms till discharge. | 2020-05-26 |
| 32364793 | The manuscript is focused mainly on anatomic pathology; however, the technologies easily lend themselves to clinical pathology education as well. | 2020-05-04 |
| 32364890 | Recent epidemiologic, virologic, and modeling reports support the possibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission from persons who are presymptomatic (SARS-CoV-2 detected before symptom onset) or asymptomatic (SARS-CoV-2 detected but symptoms never develop). […] SARS-CoV-2 transmission in the absence of symptoms reinforces the value of measures that prevent the spread of SARS-CoV-2 by infected persons who may not exhibit illness despite being infectious. | 2020-05-04 |
| 32364962 | This retrospective study aims to illustrate the radiographic characteristics of Coronavirus Disease 2019 and the correlation with the clinical course. 195 hospitalized patients confirmed as Coronavirus Disease 2019 at First Hospital of Changsha, Hunan Province from December 31, 2019 to February 20, 2020 were enrolled. […] Chest computed tomography scan, clinical data and laboratory tests results were collected accordingly. | 2020-05-29 |
| 32365190 | TREC-COVID is an information retrieval (IR) shared task initiated to support clinicians and clinical research during the COVID-19 pandemic. | 2020-05-29 |
| 32365215 | Use of hydroxychloroquine or chloroquine should be reserved to current indications or clinical trials, as recommended by several governmental medical products agencies. | 2020-05-07 |
| 32365221 | Effective laboratory markers for the estimation of disease severity and predicting the clinical progression of coronavirus disease-2019 (COVID-19) is urgently needed. […] The IL-2R/lymphocyte was a prominent biomarker for early identification of severe COVID-19 and predicting the clinical progression of the disease. | 2020-05-15 |
| 32365233 | It is supported by Diabetes UK, the Association of British Clinical Diabetologists and NHS England. | 2020-05-18 |
| 32365277 | According to clinical reports, fever, headache, cough and myalgia are common clinical symptoms. […] Many symptoms also occur, such as sputum formation, haemoptysis and diarrhea. | 2020-05-04 |
| 32365353 | Viral subgenomic fragments were generated using viral isolates, cloned viral DNA, clinical samples, or synthetic DNA, and reassembled in one step in Saccharomyces cerevisiae using transformation associated recombination (TAR) cloning to maintain the genome as a yeast artificial chromosome (YAC). | 2020-05-04 |
| 32365415 | As we recover from this pandemic, surgical cases should once again be driven by multi-disciplinary discussion and clinical trial data, and not a mentality of crisis management. | 2020-05-04 |
| 32365466 | Given the lack of registered clinical therapies or vaccines, many physicians and scientists are investigating previously used clinical drugs for COVID-19 treatment. | 2020-05-05 |
| 32365944 | In the wild type mice, SARS-CoV SUD-MC triggered the pulmonary infiltration of macrophages and monocytes, inducing CXCL10-mediated inflammatory responses and severe diffuse alveolar damage symptoms. | 2020-05-05 |
| 32366034 | This overview will address several issues concerned with the COVID-19 pandemic that directly relate to dental practice in terms of prevention, treatment, and orofacial clinical manifestations. | 2020-05-08 |
| 32366160 | Although typically described with characteristic symptoms of fever, cough, and shortness of breath, greater understanding of COVID-19 has revealed myriad clinical manifestations. | 2020-05-05 |
| 32366173 | In this article, we propose a simple memorandum of clinical recommendations to minimize the risk of operator infection deriving from epistaxis management. | 2020-05-05 |
| 32366279 | Notably, because our study is a bioinformatics assay, further functional and clinical validation is warranted. | 2020-05-07 |
| 32366290 | In this commentary, we summarize the clinical trials of MSCs treatments on ALI/ARDS and raise MSCs as a hopefully alternative therapy for severe or critical COVID-19. | 2020-05-07 |
| 32366299 | A rapidly evolving evidence suggests that smell and taste disturbance are common symptoms in COVID-19 infection. | 2020-05-06 |
| 32366319 | In their reports, the ICA provided no valid clinical scientific evidence that chiropractic care can impact the immune system. […] We call on regulatory authorities and professional leaders to take robust political and regulatory action against those claiming that chiropractic adjustments have a clinical impact on the immune system. | 2020-05-07 |
| 32366488 | Among them, demographics and clinical features of the 35 laboratory-confirmed cases were investigated and viral RNA of 12 cases was sequenced and analysed. […] All patients showed mild to moderate clinical manifestation and recovered without deterioration. […] The average periods of incubation, clinical onset serial interval (COSI), and virus shedding were 4.5 days, 5.2±3.2 days, and 18.5 days, respectively. […] SARS-CoV-2 can be rapidly transmitted person-to-person regardless of whether they have symptoms in both hospital settings and social activities based on the short period of incubation and COSI. | 2020-05-05 |
| 32366580 | COVID-19, the disease caused by the SARS-CoV-2 beta-coronavirus, has changed clinical practice in a matter of weeks. | 2020-05-05 |
| 32366614 | COVID-19 runs its course in two phases, the initial incubation phase and later clinical symptomatic phase. […] Patients in the initial incubation phase often have insidious clinical symptoms, but they are still highly contagious. […] At the later clinical symptomatic phase, the immune system is fully activated and the disease may enter the severe infection stage in this phase. […] Although many patients are known for their respiratory symptoms, they had neurological symptoms in their first 1-2 days of clinical symptomatic phase, and ischaemic stroke occurred 2 weeks after the onset of the clinical symptomatic phase. | 2020-05-14 |
| 32366658 | We find that people respond to the first report of COVID-19 in their state by immediately seeking information about COVID-19, as measured by searches for coronavirus, coronavirus symptoms, and hand sanitizer. | 2020-05-29 |
| 32366669 | Accurate and fast test results may permit more efficient use of protective and isolation resources and allow for rapid therapeutic interventions.Methods. We evaluated the analytical and clinical performance characteristics of the Xpert® Xpress SARS-CoV-2 (Xpert) test, a rapid, automated molecular test for SARS-CoV-2. […] Clinical performance was assessed using 483 remnant upper and lower respiratory specimens previously analyzed by standard of care (SOC) NAATs.Results. The limit of detection of the Xpert test was 0.01 plaque forming units (PFU)/mL. | 2020-05-05 |
| 32366746 | This article summarized the understanding of the etiology, pathogenesis, epidemiology, clinical characteristics, diagnosis, treatment, rehabilitation, and prevention and control measures of COVID-19 based on the available data and anti-epidemic experience in China. | 2020-05-05 |
| 32366816 | In March 2020, the first phase I clinical trial of a novel lipid nanoparticle (LNP)-encapsulated mRNA-based vaccine, mRNA-1273, which encodes the spike protein (S protein) of SARS-CoV-2, began in the United States (US). | 2020-05-06 |
| 32367170 | Medical history, symptoms, biological data and imaging were prospectively collected. | 2020-05-13 |
| 32367205 | Headache, anosmia, and dysgeusia are common symptoms. | 2020-05-08 |
| 32367615 | Molecular diagnostic assays based on quantitative reverse transcription polymerase chain reaction are used in most clinical laboratories. | 2020-05-27 |
| 32367746 | We briefly summarize the renin-angiotensin-aldosterone system and comprehensively review the literature pertaining to the angiotensin-converting enzyme 2/angiotensin-(1-7) pathway in children and the clinical evidence for how angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers affect this important pathway. | 2020-05-22 |
| 32367749 | Two days later, her platelet count decreased gradually without any signs or symptoms of bleeding. […] This case emphasized the importance of peripheral blood smear and clinical manifestation, especially in the differential diagnosis of thrombocytopenia. | 2020-05-14 |
| 32367765 | Clinical characteristics and indexes of coagulation function were collected. […] Based on the results of multivariate Cox analysis, a Nomogram was built and the predictive accuracy was evaluated through the calibration curve, decision curve, clinical impact curve, and Kaplan-Meier analysis. […] Sensitivity, specificity, predictive values were calculated to assess the clinical value. […] The C-index [0.712 (95% CI = 0.610-0.814)], decision curve, clinical impact curve showed that Nomogram could be used to predict the disease progression. | 2020-05-14 |
| 32367793 | Information included such as general demographic indicators, population data and clinical outcome. | 2020-05-28 |
| 32367812 | A gentleman in his early fifties became ill with flu-like symptoms after vacationing abroad and was diagnosed with COVID-19 after returning to Iceland. […] A few days later he was admitted to the University Hospital, Landspitali, due to worsening respiratory symptoms and severe fatigue. […] He subsequently showed clinical improvement and did not require endotracheal intubation. | 2020-05-06 |
| 32367837 | While patients typically present with fever and symptoms of a respiratory illness, patients have also presented with gastrointestinal symptoms such as diarrhea, vomiting and abdominal pain. | 2020-05-05 |
| 32367847 | The technique of nasopharyngeal wash to prevent the virus from inhabiting and replicating in the nasal and pharyngeal mucosa has been suggested to be useful in reducing symptoms, transmission, and viral shedding in cases of viral acute respiratory tract infections. | 2020-05-05 |
| 32367888 | This study explored the dynamic CT manifestations of COVID-19 at different times and the value of some laboratory indicators for clinical guidance. […] CONCLUSIONS The dynamic changes of CT images of lungs of COVID-19 patients, combined with the clinical manifestations and laboratory indicators of patients, can help guide clinical diagnosis and treatment. | 2020-05-06 |
| 32368429 | Radiation therapy is another essential clinical service that cannot afford to suffer prolonged delays without compromising patient outcomes. | 2020-05-08 |
| 32368483 | Its rapid progressions from mild URI symptoms to severe acute respiratory distress syndrome (ARDS) in a matter of days is the underlying reason as to why the world is struggling to keep up with ventilator production. […] He was started on hydroxychloroquine and azithromycin with no improvement of symptoms. | 2020-05-31 |
| 32368495 | As the number of COVID-19 cases increase, it will be necessary to comprehensively evaluate imaging and other clinical findings as well as consider co-infection with other respiratory viruses. | 2020-05-08 |
| 32368528 | The gastrointestinal symptoms of vomiting, diarrhea and abdominal pain and the detection of COVID-19 nucleic acid from fecal specimens in a small number of patients suggest the possibility of transmission via the gastrointestinal tract. | 2020-05-07 |
| 32368531 | In patients infected with severe acute respiratory syndrome coronavirus 2, the respiratory symptoms, such as fever, cough and dyspnea, are the most frequent clinical manifestations. […] These patients may also present with less well-defined symptoms like diarrhea, nausea, vomiting and/or abdominal discomfort both at the time of diagnosis and during the clinical course. […] In a few cases, these symptoms may also present before the appearance of respiratory symptoms. | 2020-05-08 |
| 32368570 | The clinical symptoms of COVID-19 are very similar to other respiratory viruses. […] The present study review is on the general continent, virology, pathogenesis, global epidemiology, clinical presentation, diagnosis, treatment and control of COVID-19 with the reference to India. | 2020-05-07 |
| 32368728 | Many cities have established designated fever clinics to triage suspected COVID-19 patients from other patients with similar symptoms. […] We aimed to identify simple and quickly available laboratory biomarkers to facilitate effective triage at the fever clinics for sorting suspected COVID-19 patients from those with COVID-19-like symptoms. […] We collected clinical, etiological, and laboratory data of 989 patients who visited the Fever Clinic at Wuhan Union Hospital, Wuhan, China, from Jan 31 to Feb 21. […] We compared the clinical features and laboratory findings of the two groups, and analyzed the diagnostic performance of several laboratory parameters in predicting SARS-CoV-2 infection and made relevant comparisons to the China diagnosis guideline of having a normal or decreased number of leukocytes (≤9•5 109/L) or lymphopenia (<1•1 109/L). […] The combination of eosinopenia and elevated hs-CRP can effectively triage suspected COVID-19 patients from other patients attending the fever clinic with COVID-19-like initial symptoms. | 2020-05-05 |
| 32368755 | This case highlights management strategies including the use of corticosteroids, an IL-6 inhibitor, and an aldose reductase inhibitor resulting in complete clinical recovery. | 2020-05-05 |
| 32368792 | As research continues, we have learned the genome structure, epidemiological and clinical characteristics and pathogenic mechanisms of SARS-CoV-2. […] This review will facilitate the identification of potential targets and provide promising clues for drug development that can be translated into clinical applications for combating SARS-CoV-2. | 2020-05-05 |
| 32368800 | The coronavirus 2019 (COVID-19) pandemic has had widespread implications on clinical practice at U.S. hospitals. | 2020-05-12 |
| 32368875 | During the COVID-19 outbreak, staff must use proper personal protective equipment and patients should be evaluated as the elective case according to clinical status. […] If the result is negative, RNT can be applied; but if not or if the symptoms are present, RNT must be postponed. | 2020-05-14 |
| 32368928 | The imaging findings in both groups were recorded and compared. RESULTS. Twenty-one patients with symptoms (nine men, 12 women; age range, 26-90 years) were evaluated. | 2020-05-05 |
| 32369097 | There have been recommendations to discontinue these medications, which are essential in the treatment of several chronic disease conditions, while, in the absence of clinical evidence, professional societies have advocated their continued use. […] To study the association between use of ACEIs/ARBs with the likelihood of testing positive for COVID-19 and to study outcome data in subsets of patients taking ACEIs/ARBs who tested positive with severity of clinical outcomes of COVID-19 (eg, hospitalization, intensive care unit admission, and requirement for mechanical ventilation). […] These clinical data support current professional society guidelines to not discontinue ACEIs or ARBs in the setting of the COVID-19 pandemic. […] However, further study in larger numbers of hospitalized patients receiving ACEI and ARB therapy is needed to determine the association with clinical measures of COVID-19 severity. | 2020-05-14 |
| 32369190 | Comparing the clinical presentation and epidemiological characteristics of COVID-19 with previous coronavirus-associated respiratory diseases (SARS-CoV1 and MERS) revealedsome remarkable findings and differences. […] Moreover, the clinical course of SARS-CoV-2 infection showed the complexity of COVID-19 profile with the variable clinical presentations. | 2020-05-05 |
| 32369191 | Tocilizumab, an interleukin-6 inhibitor, may ameliorate the inflammatory manifestations associated with severe coronavirus disease 2019 (COVID-19) and thus improve clinical outcomes. […] Fever (92%), cough (84%), and dyspnea (72%) were the commonest presenting symptoms. | 2020-05-11 |
| 32369204 | During the clinical course of coronavirus disease 2019 (COVID-19), it has been observed that hepatic injury occurs in a significant proportion of patients, particularly in those with severe or critical illness. | 2020-05-13 |
| 32369205 | In conclusion, two models comprised common symptoms (fever and sputum), underlying diseases (diabetes and coronary heart disease) and blood routine test are developed for predicting the future requirement of oxygen support in mild COVID-19 cases. | 2020-05-18 |
| 32369208 | Clinical and laboratory data available on patients with coronavirus disease 2019 (COVID-19) in Beijing, China remain extremely limited. […] Here, we summarized the clinical characteristics of patients with COVID-19 in a designated hospital in Beijing, China. 55 patients with laboratory-confirmed SARS-CoV-2 infection were admitted to Beijing 302 Hospital and enrolled in this study. […] Demographic data, symptoms, comorbidities, laboratory values, treatments, and clinical outcomes were all collected and retrospectively analyzed. […] The most common symptoms of illness were fever (45, 81.8%), 51 (92.7%) patients had abnormal findings on chest CT. […] Compared with patients in Wuhan, the symptoms of patients in Beijing are relatively mild. | 2020-05-05 |
| 32369209 | This retrospective study aimed to analysis clinical characteristics and outcomes of cancer patients with novel coronavirus disease-19 (COVID-19). […] Medical records, laboratory results and radiologic findings of 52 cancer patients with COVID-19 were collected, clinical characteristics and outcomes were summarized. […] The common symptoms were as follows: fever (25%), dry cough (17.3%), chest distress (11.5%) and fatigue (9.6%). | 2020-05-05 |
| 32369217 | This report focused on the outside-Wuhan patients to assess the transmission and clinical characteristics of this illness. […] Demographic, clinical and outcomes were collected and analyzed. | 2020-05-05 |
| 32369320 | Clinical research and, disproportionately, bench research were restricted. […] Rapid adoption of telehealth and reduced clinical and research experiences were important changes. | 2020-05-05 |
| 32369409 | At the Seattle Cancer Care Alliance, the primary oncology clinic for the University of Washington/Fred Hutchinson Cancer Consortium, our specialists who manage adult patients with hematologic malignancies have rapidly adjusted clinical practices to mitigate the potential risks of COVID-19 to our patients. […] Despite a rapidly changing environment that necessitates opinion-based care, we provide recommendations that are based on best available data from clinical trials and collective knowledge of disease states. | 2020-05-05 |
| 32369429 | Olfactory and gustatory dysfunction are common symptoms in patients with COVID-19 and may represent early symptoms in the clinical course of infection. […] To our knowledge, this is the first meta-analysis to report on the prevalence of these symptoms in COVID-19 patients. | 2020-05-05 |
| 32369430 | Academic otolaryngology has historically comprised a tripartite mission of research, education, and clinical care. | 2020-05-05 |
| 32369435 | Generally causing mild clinical signs of persistent cough and nasal discharge, the virus is highly infectious and is most prevalent in rehoming shelters worldwide where dogs are often closely housed and infections endemic. | 2020-05-05 |
| 32369475 | It is recommended to screen patients based on temperature, symptoms, and epidemiological factors to classify them according to their risk of infection. | 2020-05-07 |
| 32369578 | The clinical signs and symptoms of acute respiratory tract infections (RTIs) are not pathogen specific. […] Highly sensitive and specific nucleic acid amplification tests have become the diagnostic reference standard for viruses and translation of bacterial assays from basic research to routine clinical practice represents an exciting advance in respiratory medicine. […] How best to use newer molecular tests for RTI in combination with clinical judgment and traditional methods can be bewildering given the plethora of available assays and rapidly evolving technologies. | 2020-05-05 |
| 32369632 | Patients were asked about fever, cough, shortness of breath or gastrointestinal symptoms. | 2020-05-05 |
| 32369634 | The National Diabetes Stakeholders Covid-19 Response Group was formed in early April 2020 as a rapid action by the Joint British Diabetes Societies for Inpatient Care, Diabetes UK, the Association of British Clinical Diabetologists, and Diabetes Frail to address and support the special needs of residents with diabetes in UK care homes during Covid-19. […] The guidance covers the management of hyperglycaemia by discussion of various clinical scenarios that could arise, the management of hypoglycaemia, foot care and end of life care. | 2020-05-05 |
| 32369656 | We collected clinical data, vaginal secretions, stool specimens and breast milk from SARS-CoV-2-infected women during different stages of pregnancy and collected neonatal throat and anal swabs. | 2020-05-26 |
| 32369658 | The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious viral disease that predominantly causes respiratory symptoms. | 2020-05-21 |
| 32369666 | The observed risk for VTE in COVID-19 is high, particularly in ICU patients, which should lead to a high level of clinical suspicion and low threshold for diagnostic imaging for DVT or PE. | 2020-05-05 |
| 32369736 | These findings provide clinical evidence correlating improved glycemic control with better outcomes in patients with COVID-19 and pre-existing T2D. | 2020-05-29 |
| 32369975 | In contrast, the COVID-19 pandemic has been harder to contain, partly because of its wide spectrum of symptoms in infectious hosts. […] Current evidence suggests that individuals can transmit the novel coronavirus while displaying few symptoms. […] Here, we show that the proportion of infections arising from hosts with few symptoms at the start of an outbreak can, in combination with the basic reproduction number, indicate whether or not interventions targeting symptomatic hosts are likely to be effective. […] However, as an outbreak continues, the proportion of infections arising from hosts with few symptoms changes in response to control measures. […] A high proportion of infections from hosts with few symptoms after the initial stages of an outbreak is only problematic if the rate of new infections remains high. […] This should be considered when interpreting estimates of the extent of transmission from hosts with few COVID-19 symptoms. | 2020-05-06 |
| 32370116 | The present study aims to establish the prevalence of psychiatric symptoms and identify risk and protective factors for psychological distress in the general population. | 2020-05-11 |
| 32370128 | Public health planning should consider DENV inter-epidemic periodicity, the current COVID-19 pandemic and similar clinical symptomology between DF and COVID-19. | 2020-05-06 |
| 32370129 | Leveraging the recent Cloud computing and Internet of Things (IoT) technologies, this paper aims at proposing a tele-medical laboratory service where clinical exams are performed on patients directly in a hospital by technicians through IoT medical devices and results are automatically sent via the hospital Cloud to doctors of federated hospitals for validation and/or consultation. | 2020-05-08 |
| 32370561 | Early screening and triage is achievable from the outset of a pandemic with point-of-care host immune response testing which will improve response time to clinical and public health actions.Key messagesDelayed testing deployment has led to uncertainty surrounding overall disease burden and community spread, severely hampering public health containment and healthcare system preparation efforts.A multi-tiered testing strategy incorporating rapid, host immune point-of-care tests can be used now and for future pandemic planning by effectively identifying patients at risk of disease thereby facilitating quarantine earlier in the progression of the outbreak during the weeks and months it can take for pathogen specific confirmatory tests to be developed, validated and manufactured in sufficient quantities.The ability to triage patients at the point of care and support the guidance of medical and therapeutic decisions, for viral isolation or confirmatory testing or for appropriate treatment of COVID-19 and/or bacterial infections, is a critical component to our national pandemic response and there is an urgent need to implement the proposed strategy to combat the current outbreak. | 2020-05-21 |
| 32370577 | Background: To investigate the risk factors related to aggravation and clinical outcomes in coronavirus disease 2019 (COVID-19) patients.Methods: We performed a retrospective study on the risk factors for disease progression of cases with COVID-19. […] Based on the clinical types, the patients were divided into a progression group and an improvement group. | 2020-05-27 |
| 32370606 | Diabetes is associated with poor clinical outcomes in hospitalized patients with coronavirus disease 2019 (COVID-19). […] Not optimizing glycemic control due to clinical inertia driven by fear or lack of supplies may lead to poor outcomes in patients with diabetes and COVID-19. | 2020-05-06 |
| 32370747 | Compared to adults, there are relatively few studies on COVID-19 infection in children, and even less focusing on the unique features of COVID-19 in children in terms of laboratory findings, locations of computerized tomography (CT) lesions, and the role of CT in evaluating clinical recovery. […] Clinical, imaging, and laboratory data of 76 children were collected retrospectively and analyzed with the Fisher exact test and Cox regression statistical methods. […] CT is a powerful tool to detect and characterize COVID-19 pneumonia but has little utility in evaluating clinical recovery for children. | 2020-05-08 |
| 32370758 | Currently, drugs originally developed for other viruses or parasites are currently in clinical trials based on empiric data. | 2020-05-11 |
| 32370766 | While many of these adjunctive drugs are being investigated in clinical trials, professional bodies have attempted to clarify the setting where the use of these drugs may be considered as off-label or compassionate use. […] This review summarizes the clinical evidence of investigational adjunctive treatments used in COVID-19 patients as well as the recommendations of their use from guidelines issued by international and national organizations in healthcare. | 2020-05-07 |
| 32370982 | They should also be trained to prevent, detect and treat early warning symptoms of post-traumatic stress disorder, because their prevalence was high in the regions of China most affected by the pandemic. | 2020-05-08 |
| 32370983 | Due to the broad psychopathological consequences, we have to look for these various symptoms to manage them. | 2020-05-08 |
| 32370984 | We highlighted most relevant data concerning the disease characteristics, the organizational factors and personal factors that may contribute to developing psychological distress and other mental health symptoms. […] The disease characteristics of the current COVID-19 pandemic provoked a generalized climate of wariness and uncertainty, particularly among health professionals, due to a range of causes such as the rapid spread of COVID-19, the severity of symptoms it can cause in a segment of infected individuals, the lack of knowledge of the disease, and deaths among health professionals. | 2020-05-08 |
| 32371006 | Diarrhea appeared 4.5 days (±1.8) after the onset of the first other symptoms in COVID-19. […] Myalgia, sore throat, sneezing and the other GI symptoms were statistically more frequent in the group with diarrhea than in the group without diarrhea (P<0.05). | 2020-05-08 |
| 32371192 | The differential diagnosis between novel coronavirus pneumonia patients (NCPP) and influenza patients (IP) remains a challenge in clinical practice. | 2020-05-29 |
| 32371231 | WBE surveillance of populations is shown to be orders of magnitude cheaper and faster than clinical screening, yet cannot fully replace it. […] Effective surveillance may be envisioned as a two-step process in which WBE serves to identify and enumerate infected cases, where after clinical testing then serves to identify infected individuals in WBE-revealed hotspots. | 2020-05-31 |
| 32371416 | Following treatment with oseltamivir and short-term methylprednisolone combined with symptomatic management, all three patients recovered within 3 weeks, as evidenced by the disappearance of their symptoms, clearance of pulmonary infiltrates and consecutive negative molecular diagnostic test findings. | 2020-05-07 |
| 32371417 | A 40-year-old man developed acute brainstem dysfunction 3 days after hospital admission with symptoms of the novel SARS-CoV-2 infection (COVID-19). | 2020-05-06 |
| 32371463 | Our study aims to present a summary of the clinicopathological characteristics of patients affected by the coronavirus disease 2019 (COVID-19) that can be used as a reference for further research and clinical decisions. […] Studies were included in the meta-analysis if they had cohort, case-control or case series designs and provided sufficient details on clinical symptoms, laboratory outcomes and asymptomatic patients. […] Meta-analysis showed that a higher proportion of infected patients were male (53.3%), and the two major symptoms observed were fever (78.4%) and cough (58.3%). […] Other common symptoms included fatigue (34%), myalgia (21.9%), expectoration (23.7%), anorexia (22.9%), chest tightness (22.9%) and dyspnoea (20.6%). […] Minor symptoms included nausea and vomiting (6.6%), diarrhoea (8.2%), headache (11.3%), pharyngalgia (11.6%), shivering (15.2%) and rhinorrhea (7.3%). […] The most commonly experienced symptoms of patients with COVID-19 were fever and cough. | 2020-05-11 |
| 32371466 | Any study that described the psychological reactions of healthcare staff working with patients in an outbreak of any emerging virus in any clinical setting, irrespective of any comparison with other clinicians or the general population. 59 papers met the inclusion criteria: 37 were of severe acute respiratory syndrome (SARS), eight of coronavirus disease 2019 (covid-19), seven of Middle East respiratory syndrome (MERS), three each of Ebola virus disease and influenza A virus subtype H1N1, and one of influenza A virus subtype H7N9. | 2020-05-07 |
| 32371477 | This mobile application offers data on risk factors, herald symptoms, clinical outcomes, and geographical hot spots. | 2020-05-09 |
| 32371536 | However, the frequency and clinical significance of direct infection in COVID-19 is unclear. | 2020-05-07 |
| 32371551 | This mobile application collects information on risk factors, daily symptoms, and outcomes through a user-friendly interface that minimizes participant burden. […] The linkage of symptom data collected in the app with information and biospecimens already collected in epidemiology cohorts will position us to address key questions related to diet, lifestyle, environmental and socioeconomic factors on susceptibility to COVID-19, clinical outcomes related to infection, and long-term physical, mental health, and financial sequalae. | 2020-05-09 |
| 32371558 | There are also no clinical trial data supporting prophylactic HCQ therapy in COVID-19. | 2020-05-06 |
| 32371563 | Symptoms that may differentiate COVID-19 from asthma exacerbations caused by another trigger may include fever, fatigue, anorexia, or myalgias. | 2020-05-06 |
| 32371564 | Information about the clinical presentation and course of COVID-19 is rapidly evolving. […] Data are emerging from retrospective clinical studies conducted in Wuhan, China, showing the symptoms and characteristics of COVID-19 caused by severe acute respiratory virus coronavirus 2 (SARS-CoV-2) infection, including fever, cough, and shortness of breath. | 2020-05-16 |
| 32371611 | Of 178 potentially eligible patients with symptoms of coronavirus disease 2019, 23 patients (12.92%) were diagnosed as suspected cases, and one patient (0.56%) suffered from cardiac arrest immediately after admission. […] Acute Physiology and Chronic Health Evaluation II score was an effective clinical tool to predict hospital mortality in patients with coronavirus disease 2019 compared with Sequential Organ Failure Assessment score and CURB65 score. […] Acute Physiology and Chronic Health Evaluation II score greater than or equal to 17 serves as an early warning indicator of death and may provide guidance to make further clinical decisions. | 2020-05-15 |
| 32372026 | Observational studies were analyzed for quality using the modified Newcastle-Ottawa scale and randomized clinical trials, using the Jadad scale. […] We included 11 reports including 10 cohort studies and 1 randomized clinical trial involving 5249 subjects (2003-2020). […] Because of a preponderance of observational studies in the dataset and selection and publication biases our conclusions, especially regarding SARS-CoV-2, need confirmation in a randomized clinical trial. | 2020-05-08 |
| 32372695 | Multiple off-label and investigational drugs, such as chloroquine and hydroxychloroquine, have gained broad interest due to positive pre-clinical data and are currently used for treatment of COVID-19. | 2020-05-29 |
| 32372752 | A 25-year-old medical student presented in Multan, Pakistan with a high fever, cough, myalgia, and diarrhea consistent with the typical signs and symptoms of novel coronavirus disease (COVID-19). | 2020-05-06 |
| 32372784 | We don’t yet know if being exposed to more coronavirus particles leads to more severe covid-19 symptoms, reports Linda Geddes. | 2020-05-06 |
| 32373183 | Although much of this attention has a mechanistic basis, the hard efficacy data for chloroquine/hydroxychloroquine in the management of the clinical syndrome of COVID-19 have been limited thus far. […] This review aims to present the available in vitro and clinical data for the role of chloroquine/hydroxychloroquine in COVID-19 and attempts to put them into perspective, especially in relation to the different risks/benefits particular to each patient who may require treatment. | 2020-05-20 |
| 32373235 | CT features, adjusted for age and gender, on day 4 and in terms of changes from day 0 to day 4 outperformed APACHE-II, NLR, and d-dimer. Conclusions: CT quantification of pneumonia lesions can early and non-invasively predict the progression to severe illness, providing a promising prognostic indicator for clinical management of COVID-19. | 2020-05-07 |
| 32373237 | However, the imaging risk factors for poor clinical outcomes remain unclear. […] Clinical and initial CT findings at admission were extracted from medical records. […] Patients aged < 18 years or without available clinical or CT records were excluded. | 2020-05-07 |
| 32373340 | We prospectively collected the demographic and clinical data of the first 38 fatalities whose information was made public by the Health Commission of Hubei province and the official Weibo account of China Central Television news center, starting from 9 January through 24 January 2020. […] The death cases were described from four aspects (gender and age characteristics, underlying diseases, the time course of death, symptoms at the incipience of illness and hospital admission). […] The median time between the first symptoms and death was 12.50 days (IQR = 10.00-16.25), while the median time between the admission and death was 8.50 (IQR = 5.00-12.00) days. […] In persons aged over 56 years, the time between the first symptoms and death decreased with age, and so did the time between the admission and death, though the latter increased again in persons aged over 85 years. […] The major first symptoms included fever (52.63%), cough (31.58%), dyspnea (23.68%), myalgia and fatigue (15.79%). […] The time between the first symptoms and death decreased with the advanced age. | 2020-05-08 |
| 32373467 | These patients tested positive on RT-PCR of naso-pharyngeal swabs and developed no fever, malaise, or respiratory symptoms throughout the course of their illness. […] In the current efforts to fight the spread of this virus, authors want to emphasize that atypical clinical presentations of COVID-19 can occur and a high level of suspicion should be maintained. […] For this reason, eye protection in the form of goggles or a face shield should be considered essential for all healthcare providers, even when taking care of patients who are not showing typical symptoms of COVID-19. | 2020-05-08 |
| 32373990 | A combination of chest CT and repeat Reverse Transcription-Polymerase Chain Reaction (RT-PCR) testing may be beneficial for the diagnosis of COVID-19 in the setting of strongly clinical suspicion. | 2020-05-08 |
| 32373992 | In this short report, combined with the progress of preclinical and clinical research, we comment the efficacy of MSCs in the treatment of COVID-19. | 2020-05-08 |
| 32373993 | We reviewed in vitro studies, in vivo studies, original studies, clinical trials, and consensus reports, that were conducted to evaluate the antiviral activities of chloroquine and hydroxychloroquine. […] The studies on "COVID-19 and its allied treatment were found from World Health Organization (WHO), ISI-Web of Science, PubMed, EMBASE, Scopus, Google Scholar, and clinical trial registries. […] For this study, we identified a total of 09 published articles: 03 clinical trials with sample size 150; 03 in vitro studies and 03 expert consensus reports. […] It is reasonable, given the hypothetical benefit of these two drugs, that they are now being tested in clinical trials to assess their effectiveness to combat this global health crisis. | 2020-05-08 |
| 32373998 | Meanwhile, we analyzed the epidemiologic and clinical characteristics of COVID-19, in order to provide recommendations for present clinical treatments and inspirations for potential therapy options. | 2020-05-08 |
| 32373999 | Here we present an overview of the viral structure, pathogenesis, diagnosis, and clinical features of COVID-19 based on the current state of knowledge, and we compare its clinical characteristics with SARS and Middle East Respiratory Syndrome (MERS). | 2020-05-08 |
| 32374001 | This study aimed to provide a summary of the up-to-dated clinical display, diagnostics, molecular and genetic implications for COVID-19 infected patients. […] In this review, 73 research articles published before 25 March 2020 were analyzed to better understand the clinical characteristics of patients and to introduce the available serological, hematology and molecular diagnostic methods. […] Apart from articles extracted from PubMed and Google Scholar, WHO (https://www.who.int/), NHC (National Health Commission of the People’s Republic of China (http://www.nhc.gov.cn/), NICE (National Institute for Health and Clinical Excellence, https://www.nice.org.uk/), CDC (Centers for Disease Control and Prevention, https://www.cdc.gov/), and National Administration of Traditional Chinese Medicine (http://www.satcm.gov.cn/) were also accessed to search for eligible studies. […] Papers published between January 1, 2020, and 25 March 2020 were searched in English and the terms “2019-nCoV, Covid-19, Clinical Characteristics OR manifestation, method of detection, COVID-19 Genome and molecular test” were used. […] All the data in this article will assist researchers and clinicians to develop their clinical views regarding infected patients and to emphasize the origin of SARS-CoV-2 for diagnostics. | 2020-05-08 |
| 32374007 | Chinese Clinical Guidance for COVID-19 Pneumonia Diagnosis and Treatment (7th edition) by National Health Commission is recommended to follow as it provides detailed diagnostic procedures using currently available tools. | 2020-05-08 |
| 32374032 | 1] The relationship between these symptoms and faecal calprotectin would be interesting to note. | 2020-05-06 |
| 32374033 | We present four children investigated for suspected COVID-19 infection with who presented with acral skin findings and mild systemic symptoms. | 2020-05-06 |
| 32374074 | Through a total of 1 485 144 screenings, 64 potential drugs (11 approved, 14 clinical, and 39 preclinical drugs) were predicted to show high binding affinity with Mpro . […] The procedure used in this study is a possible strategy for discovering anti-SARS-CoV-2 drugs from drug libraries that may significantly shorten the clinical development period with regard to drug repositioning. | 2020-05-29 |
| 32374208 | If provided a simple surveillance form, their detection of symptoms (lethargy, hyposmia, anosmia, and others) might be quickly reported to a central data collection site if one were created. | 2020-05-28 |
| 32374248 | Coronavirus disease 2019 (COVID-19) patients were classified into four clinical stages (uncomplicated illness, mild, severe and critical pneumonia) depending on disease severity. […] We aim to investigate the corresponding clinical, radiological and laboratory characteristics between different clinical stages. […] Clinical data were collected and compared during the course of illness. […] Fever (68%), cough (50%) and fatigue (23%) are the most common symptoms. […] Significant differences were observed among groups of different clinical stages in numbers of influenced pulmonary segments (6 vs. 12 vs. | 2020-05-18 |
| 32374264 | Real-world drug repurposing-the immediate “off-label” prescribing of drugs to address urgent clinical needs-is a widely overlooked opportunity. […] Clinical trials to assess efficacy are already underway for famotidine, dipyridamole, and sildenafil, and further trials of all these agents will be important in due course. | 2020-05-26 |
| 32374289 | We show that an individual-patient-based, beneficence-based deliberative clinical judgment is not an adequate basis for organizational policy in response to a public health emergency. […] Instead, physicians, especially those in leadership positions, must frameshift to population-based clinical ethical judgment that focuses on reduction of mortality as much as possible in the entire population of patients served by a healthcare organization. | 2020-05-06 |
| 32374419 | One of the reasons for the rapid spread is that the virus can be transmitted from infected individuals without symptoms. […] Detailed clinical, laboratory and radiological data were also described. | 2020-05-06 |
| 32374430 | In a rapidly evolving pandemic such as COVID-19, theories which help unify disparate pre-clinical and clinical observations would be useful. | 2020-05-08 |
| 32374440 | The resulting recommendations defend a particular view of distributive justice that maximizes relevant clinical factors and de-emphasizes or eliminates factors placing arbitrary, disproportionate weight on advanced age. | 2020-05-14 |
| 32374457 | These results warrant further investigations of the potential of nelfinavir mesylate to inhibit virus spread at early times after SARS CoV-2 symptoms appear. | 2020-05-18 |
| 32374537 | A limitation of the propagation, the understanding of the functioning of the virus and its clinical manifestations, the administration of specific treatments, rapid and reliable diagnostic tools are the basis of the fight against this germ, which is still little known today. | 2020-05-08 |
| 32374538 | The clinical presentation of COVID-19 range from non-specific symptoms to adult acute respiratory distress syndrome (ARDS). | 2020-05-08 |
| 32374546 | We conclude with important considerations in terms of students’ clinical supervision. | 2020-05-08 |
| 32374806 | The authors analyzed stress, anxiety, and depression with the arrival of the virus and the levels of symptoms according to age, comorbidity, and confinement. […] Although levels of symptoms were generally low at the start of the alert, younger individuals with chronic diseases reported more symptoms than the rest of the population. […] The study also detected higher levels of symptoms after the stay-at-home order was issued. […] Such symptoms are predicted to increase as the confinement continues. | 2020-05-11 |
| 32374815 | To validate and compare clinical findings with data from medical autopsy, virtual autopsy, and virologic tests. […] Clinical data and medical course were evaluated. Results: Median patient age was 73 years (range, 52 to 87 years), 75% of patients were male, and death occurred in the hospital (n = 10) or outpatient sector (n = 2). […] Further studies are needed to investigate the molecular mechanism and overall clinical incidence of COVID-19-related death, as well as possible therapeutic interventions to reduce it. | 2020-05-23 |
| 32374823 | As per the results, Prevotella proteins, but not viral proteins are involved in multiple interactions with NF-kB, which is involved in increasing clinical severity of COVID-2019. | 2020-05-06 |
| 32374903 | Physicians should be aware of this characteristic of the virus to anticipate the clinical course of infection. | 2020-05-06 |
| 32375085 | Subsequently, the virus spreads out and damages other vital organs and tissues, triggering a complicated spectrum of pathophysiological changes and symptoms, including cardiovascular complications. […] Diverse clinical manifestations and laboratory abnormalities occur in patients with cardiovascular injury in COVID-19, characterizing the development of this complication, as well as providing clues to diagnosis and treatment. […] This review provides a summary of the rapidly appearing laboratory and clinical evidence for the pathophysiology and therapeutic approaches to COVID-19 pulmonary and cardiovascular complications. | 2020-05-08 |
| 32375150 | We pre-sent a report of a patient with COVID-19 who presented with acute onset of symptoms and normal renal function at baseline but rapidly deteriorated resulting in death. […] The timing of decline in renal function correlated with his worsening clinical status. […] He was started on continuous veno-venous hemofiltration without signs of clinical benefit. | 2020-05-06 |
| 32375197 | These articles could be classified into the topics “Modes and prevention of (ocular) transmission”, “Ophthalmological manifestations of COVID-19”, “Clinical guidance concerning ophthalmological practice during the COVID-19 pandemic”, and “Practical recommendations for clinical infrastructure”. | 2020-05-22 |
| 32375201 | As a result, the public health and clinical community are hindered in their ability to monitor and contain the spread of COVID-19. | 2020-05-28 |
| 32375488 | Coronavirus disease 2019 may present with a wide range of clinical spectrum and severity, including severe interstitial pneumonia with high prevalence of hypoxic respiratory failure requiring intensive care admission. […] There has been increasing sharing experience regarding the patient’s clinical features over the last weeks which has underlined the need for general guidance on treatment strategies. | 2020-05-29 |
| 32375845 | The clinical manifestations were relatively mild in some COVID-19 patients, which was inconsistent with the severity of laboratory and imaging findings. | 2020-05-11 |
| 32375887 | Opiate users may misinterpret SARS-CoV2 symptoms as opiate withdrawal and manage this by using opioids. | 2020-05-11 |
| 32375909 | Therefore, we intend to shed light on its potential clinical and epidemiological characteristics. […] According to the contents of the reports, we recorded in detail the gender, age, first symptom date, death date, primary symptoms, chronic fundamental diseases, and other data of the patients, and carried out analyses and discussion. | 2020-05-23 |
| 32376004 | Clinically, symptoms suggestive of COVID-19 (fever, cough, dyspnea, digestive signs) can be caused by various psychotropic drugs and require vigilance to avoid false negatives and false positives. […] For these two treatments the possibility of a reduction in the dosage - in case of minimal infectious signs and in a situation, which does not allow rapid control - should ideally be considered taking into account the clinical response (even biological; plasma concentrations) observed in the face of previous dose reductions. […] In a COVID+ patient, the consequences of an abrupt cessation of smoking, particularly related with the appearance of respiratory symptoms (cough, dyspnea), must therefore be anticipated for patients receiving psychotropics metabolized by CYP1A2. | 2020-05-09 |
| 32376072 | There is an increasing number of reports on the presentation of gastrointestinal symptoms in cases of COVID-19. […] To review the studies reporting gastrointestinal symptoms in COVID-19. […] Those symptoms can be the first manifestation of COVID-19, but whether they reflect a better or worse prognosis, is controversial. […] Gastrointestinal symptoms may be common in COVID-19, in some cases appearing as the first manifestation, even before fever and respiratory symptoms. | 2020-05-17 |
| 32376098 | Information is lacking on the clinical impact of the novel coronavirus, SARS-CoV-2, on people with cystic fibrosis (CF). | 2020-05-09 |
| 32376101 | These results may help guide the clinical management of patients with severe COVID-19, particularly in settings requiring strategic allocation of limited critical care resources. | 2020-05-09 |
| 32376170 | Owing to this particular novel and highly infectious strain of coronavirus, the rapid community spread and clinical severity of the subsequent respiratory syndrome created a substantial strain on hospitals and health care systems around the world. […] The rapid surge of patients presenting over a small period for emergent clinical care, admission to the hospital, and intensive care units with many requiring mechanically assisted ventilators for respiratory support demonstrated the potential to overwhelm health care workers, hospitals, and health care systems. […] The purpose of this article is to describe an effective system for redeployment of health care supplies, resources, and personnel to hospitals within a suburban academic hospital system to optimize the care of COVID patients, while treating orthopedic patients in an equally ideal setting to maximize their surgical and clinical care. | 2020-05-09 |
| 32376263 | To partially overcome these issues “WhatsApp” has been adopted to get family members to participate in clinical rounds. […] Four formal questions were posed: 1) Are you happy to virtually attend the clinical round? […] 3) Do you think that your loved one was happy to see you during the clinical rounds? […] 4) This technology may substitute your presence during the clinical rounds? | 2020-05-22 |
| 32376308 | Lymphopenia is a prominent part of severe COVID-19 and a lymphocyte count of less than 1.5×109/L may be useful in predicting the severity clinical outcomes. | 2020-05-31 |
| 32376309 | Patients who have COVID-19 may already be infectious before there are symptoms, and 14 days of isolation after diagnosis may be sufficient in entirely asymptomatic cases. | 2020-05-29 |
| 32376359 | An mRNA-based anti-COVID-19 candidate vaccine has entered a phase 1 clinical trial. | 2020-05-28 |
| 32376368 | Chinese Medicines (CMs) had been used to treat and prevent viral infection pneumonia diseases for thousands of years and had accumulated a large number of clinical experiences and effective prescriptions. | 2020-05-30 |
| 32376392 | This unprecedented situation led to the inception of numerous fundamental research protocols and many clinical trials. […] Next, reviewing current evidence drawn from clinical trials, we examine a number of cytokine and anti-cytokine therapies, including interleukin-1, -6, and TNF inhibitors, as well as less targeted therapies, such as corticosteroids, chloroquine, or JAK inhibitors. | 2020-05-11 |
| 32376395 | In this cross-sectional study, Tuscan outpatients with systemic autoimmune diseases followed at a tertiary referral centre were telephonically interviewed between April 1st-14th 2020 to collect demographic and clinical data, information on ongoing immunomodulating/immunosuppressive treatments, and on the presence of symptoms suspected of SARS-CoV-2 or of a confirmed infection. 458 patients were interviewed [74% female, median age 56 years (IQR 43-68)]; 56% of them were receiving corticosteroids, 44% traditional disease-modifying anti-rheumatic drugs (DMARDs), of whom 23% hydroxychloroquine, 5% colchicine, while 41% were on biologic DMARDs (of whom 9% on tocilizumab). […] Thirteen patients reported symptoms suggesting SARS-CoV-2 infection. | 2020-05-10 |
| 32376397 | In the current pandemic era, although there have been many efforts to diagnose a number of patients with symptoms or close contacts, there is no definite guideline for the initial therapeutic approach for them and therefore, many patients have been dying due to a hyperinflammatory immunological reaction labeled as “cytokine storm”. […] Currently, however, no treatment is provided for those who are isolated at home or shelter until they get severe symptoms, which will increase the harms to the patients. | 2020-05-30 |
| 32376398 | A third infusion was optional based on clinical response. […] The response to TCZ was rapid, sustained, and associated with significant clinical improvement. | 2020-05-29 |
| 32376543 | Among the 23 patients with pneumonia, 9 (39.1%) had common or severe SARS-CoV-2- associated pneumonia with a positive epidemiological history and corresponding respiratory symptoms. | 2020-05-08 |
| 32376573 | To investigate the correlation between the clinical classification of coronavirus disease 2019 (COVID-19) and the imaging characteristics of multislice spiral computed tomography (MSCT) volume scanning of the lungs. […] The clinical data and thoracic MSCT volume scanning data were analyzed retrospectively for 102 patients with COVID-19 diagnosed and hospitalized in the First Affiliated Hospital of Bengbu Medical College between January 18 and February 26, 2020. […] The imaging characteristics including the lung sides of the lesions, lung segment involved, lesion distribution, and lesion number and density were compared among the patients with different clinical types of COVID-19. […] The main clinical manifestations included fever, cough and fatigue. […] Severe and critical types were more frequently seen in elderly patients, who were more prone to show such symptoms as asthenia, breathing difficulty and dyspnea. […] The lesion side, lesion number or lesion density did not differ significantly among the patients with different clinical types of COVID-19 (P > 0.05). […] MSCT volume scanning not only allows early diagnosis of COVID-19 but also provides evidence for evaluating the severity of COVID-19 to assist in the clinical treatment of the patients. | 2020-05-11 |
| 32376581 | We retrospectively analyzed the clinical data of 63 patients with COVID- 19 from Hubei Provincial Hospital of Integrated Chinese and Western Medicine, including 32 moderate cases and 31 severe cases. […] The demographic data, underlying diseases, clinical manifestations and laboratory test results were compared between the two groups. | 2020-05-11 |
| 32376587 | In the setting of epidemics of communicable diseases, early initiation of epidemiological and clinical data collection and analysis and conducting relevant researches are essential to the success of epidemic containment. […] We recommend that clinical research and health economics research be incorporated into the prevention and control plan and measures be taken to ensure both the standards and feasibility of these studies to improve the response capacity against outbreaks of communicable diseases. | 2020-05-11 |
| 32376589 | ObjectiveTo define chest CT findings and their dynamic changes in patients with coronavirus disease 2019 (COVID-19) from disease onset to the cure.MethodWe analyzed the clinical and chest CT data of 6 patients with RT-PCR-confirmed COVID-19. | 2020-05-11 |
| 32376592 | To analyze the clinical characteristics of patients with severe or critical coronavirus disease 2019 (COVID-19) receiving tracheal intubation. […] We analyzed clinical characteristics of 18 severely or critically ill patients with COVID-19 undergoing tracheal intubation. […] The general demographic and clinical data of the patients including their age, gender, pre- intubation state of consciousness and the ventilation mode were recorded. | 2020-05-11 |
| 32376593 | We collected clinical blood samples from voriconazole-treated patients in heparinized tubes and sterilized the surface of the tubes with 75% ethanol. | 2020-05-11 |
| 32376603 | These data support clinical development of SARS-CoV-2 vaccines for humans. | 2020-05-22 |
| 32376700 | Porcine hemagglutinating encephalomyelitis virus (PHEV), a lesser-researched coronavirus, can infect naive pigs of any age, but clinical disease is observed in pigs ≤4 weeks of age. […] Although subclinical PHEV infections are thought to be common, PHEV ecology in commercial swine herds is unknown. | 2020-05-20 |
| 32377462 | The highest percentage of correct responses were from undergraduate medical students and the lowest was from non-clinical/administrative staff. | 2020-05-09 |
| 32377468 | Her symptoms started six days prior to presentation with no cough, rhinorrhea, or other respiratory manifestations reported. […] These findings serve as a practical reference for the clinical diagnosis and medical treatment of children with COVID-19. | 2020-05-09 |
| 32377469 | We report an interesting 2019-nCoV case in a tertiary community hospital with the initial concern of acute pyelonephritis without respiratory symptoms that ultimately led to the quarantine of a number of healthcare providers. | 2020-05-09 |
| 32377559 | This manuscript reviews the epidemiology, etiology, mortality, COVID-19 clinical symptoms, and potential therapeutic drugs, while highlighting the seriousness and damage-induced by SARS-CoV-2. | 2020-05-09 |
| 32377594 | A 63-year-old male was admitted in intensive care unit (ICU), seven days after the beginning of an influenza-like symptoms, to manage an acute respiratory syndrome related with SARS-CoV-2. | 2020-05-31 |
| 32377596 | Radiation Oncology made aggressive efforts to reduce patients on treatment to protect patients and staff as well reallocate staff and space for more acute clinical needs. […] The majority of residents were deployed into COVID-19 clinical settings. | 2020-05-07 |
| 32377597 | Radiation pneumonitis (RP) is a common toxicity of thoracic radiotherapy with overlapping clinical and imaging features with COVID-19, however, RP is treated with high-dose corticosteroids, which may exacerbate COVID-19-associated lung injury. […] We reviewed patients who presented with symptoms of RP during the intensification of a regional COVID-19 epidemic to report on their clinical course and COVID-19 testing results. […] The clinical course and chest computed tomography (CT) imaging findings of consecutive patients who presented with symptoms of RP in March 2020 were reviewed. […] Four patients with clinical suspicion for RP were assessed. […] All patients presented with symptoms of cough and dyspnea. […] Two patients started on an empiric high-dose corticosteroid taper for presumed RP, but both had clinical deterioration, and ultimately tested positive for COVID-19 and required hospitalization. […] As this pandemic continues, patients with symptoms of RP require diagnostic attention. | 2020-05-10 |
| 32377638 | To date, there is no specific vaccine against the causative virus, SARS-CoV-2, nor is there an effective medicine for treating COVID-19, thus raising concerns with respect to the effect of risk factors such as clinical course and pathophysiological parameters on disease severity and outcome in patients with COVID-19. […] By extracting and analyzing all available published clinical data, we identified several major clinical characteristics associated with increased disease severity and mortality among patients with COVID-19. […] Moreover, additional clinical data are needed in order to determine whether a supportive therapy can help mitigate the development of severe, potentially fatal complications, and further studies are needed to identify the pathophysiology and the mechanism underlying this novel coronavirus-associated infectious disease. […] Taken together, these findings provide new insights regarding clinical strategies for improving the management and outcome of patients with COVID-19. | 2020-05-09 |
| 32377677 | We frame our findings within an overview of the disease and have also evaluated the inclusion of older people within forthcoming clinical trials. […] Exclusion of older people, particularly those with comorbidities, from clinical trials is well recognised and is potentially being perpetuated in the field of current COVID-19 research. | 2020-05-29 |
| 32377694 | The most difficult scientific challenge for this future vaccine obtained in the laboratory is the proof of clinical safety and efficacy. | 2020-05-07 |
| 32377709 | All age groups can be infected from the virus, but more serious symptoms that can possibly result in death are observed in older people and those with underlying medical conditions such as cardiovascular and pulmonary disease. […] Novel data report more severe symptoms and even a negative prognosis for the obese patients. | 2020-05-19 |
| 32378030 | The COVID-19 pandemic is associated with neurological symptoms and complications including stroke. | 2020-05-22 |
| 32378314 | Because of a lack of clinical improvement several days later, tocilizumab, methylprednisolone, and therapeutic anticoagulation were initiated. | 2020-05-22 |
| 32378325 | Liver Transplant Programs in Italy have faced a sequela of management and clinical decision-making problems due to the high incidence in some regions of the country of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2). | 2020-05-07 |
| 32378464 | A summary of available clinical guidelines with recommendations is presented, to provide community nurses with the up-to-date information required for protecting individuals living with a number of long-term conditions. | 2020-05-08 |
| 32378471 | Current clinical treatment at hand is inadequate to suppress viral replication and inflammation, and reverse organ failure. | 2020-05-15 |
| 32378648 | Even though remdesivir was proposed as a promising option for treating COVID-19 based on laboratory experiments and reports from compassionate use, its safety and effect in humans requires high-quality evidence from well-designed and adequately-powered clinical trials for further clarification. | 2020-05-08 |
| 32378705 | From India, two clinical isolates have been sequenced and the full genome has been deposited in GenBank. | 2020-05-18 |
| 32378737 | In summary, the likelihood of a successful clinical trial using the approved dose of ivermectin is low. | 2020-05-07 |
| 32378743 | The etiopathogenesis and clinical implications of these lesions remains unclear. | 2020-05-07 |
| 32378797 | The COVID-19 Emergency Department (COVED) Quality Improvement Project aims to provide regular and real-time clinical information to ED clinicians caring for patients with suspected and confirmed COVID-19. […] The mean age of patients was 60 years and the commonest symptoms were acute shortness of breath (n = 122 [67%]), cough (n = 108 [56%]) or fever (n = 98 [51%]). […] Although the low incidence of positive cases currently precludes the development of predictive tools, the COVED Project demonstrates that the rapid establishment of an agile clinical registry for emergency care is feasible. | 2020-05-19 |
| 32378801 | In this article, we compared SARS-CoV-2 with SARS-CoV and influenza virus, discussed current researching progress of COVID-19, including clinical characteristics, pathological changes, treatment measures, and so on. | 2020-05-22 |
| 32378805 | This pandemic has proven to be a challenge given that there is no immediate cure, no vaccine is currently available and medications or treatments being used are still undergoing clinical trials. […] This evidence needs to be backed by large randomised-controlled clinical trials. | 2020-05-13 |
| 32378815 | In February 2020, the World Health Organisation designated the name COVID-19 for a clinical condition caused by a virus identified as a cause for a cluster of pneumonia cases in Wuhan, China. […] Clinical, laboratory, and epidemiological data gathered during their hospitalization are presented. | 2020-05-08 |
| 32378844 | The COVID-19 outbreak is presenting the health system with new challenges, and there is a great need for knowledge about symptoms, clinical findings and course of illness in patients admitted to Norwegian hospitals with COVID-19. […] We present here patient characteristics, symptoms, clinical findings, experience of using clinical scoring systems and course of illness based on data in medical records. […] Fever (79 %), reduced general condition (79 %), dyspnoea (69 %) and cough (67 %) were the most common symptoms. […] Most patients admitted to our hospital with COVID-19 had a fever and respiratory tract symptoms. | 2020-05-12 |
| 32378845 | Healthcare professionals should be aware that such symptoms may be due to COVID-19. | 2020-05-12 |
| 32378854 | We report on two cases (spouses) with SARS-CoV-2 infection with self-reported OTDs, but otherwise no typical respiratory symptoms of COVID-19. […] A man in his nineties (index patient) had respiratory symptoms and dysgeusia, and was diagnosed with COVID-19. […] His daughter-in-law and son had no respiratory COVID-19 symptoms. […] Our case histories support recent reports hypothesising that anosmia and ageusia may be the only symptoms of SARS-CoV-2 infection, and that SARS-CoV-2 may infect oral and nasal tissues. | 2020-05-12 |
| 32378864 | In addition to abdominal pain, she had vomiting, loss of appetite, diarrhoea and symptoms of pyrexia. […] She had no symptoms from the respiratory tract, but was later found to have COVID-19. […] A number of patients have presented with similar symptoms at our hospital. | 2020-05-12 |
| 32379056 | Outpatient visits are reduced under well protected after appointment, and rigorous investigation of epidemiological history and clinical symptoms are needed. | 2020-05-26 |
| 32379070 | The availability of COVID-19 clinical guidelines and patient information sheets on national plastic surgery society websites is limited. | 2020-05-07 |
| 32379077 | While in some cases a history of fever and/or respiratory distress (e.g. cough or shortness of breath) may suggest the diagnosis, epidemiologic studies indicate that the majority of individuals infected with COVID-19 develop mild to no symptoms. | 2020-05-09 |
| 32379114 | Studies of the novel coronavirus-induced disease COVID-19 in Wuhan, China, have elucidated the epidemiological and clinical characteristics of this disease in the general population. […] The present investigation summarizes the clinical characteristics and early prognosis of COVID-19 infection in a cohort of patients with fractures. […] Analyses of early prognosis were based on clinical outcomes and trends in laboratory results during treatment. […] The clinical outcomes for the surviving patients are not yet determined. […] The clinical characteristics and early prognosis of COVID-19 in patients with fracture tended to be more severe than those reported for adult patients with COVID-19 without fracture. […] This finding may be related to the duration between the development of symptoms and presentation. | 2020-05-20 |
| 32379191 | This study aims to investigate the clinical and laboratory characteristics associated with viral shedding in children with mild COVID-19. […] The clinical and laboratory information of 110 children with COVID-19 at Wuhan Children’s Hospital, Wuhan, China, from January 30 to March 10, 2020, were analyzed retrospectively. […] Monitoring of symptoms could help to know the viral shedding in children with COVID-19. | 2020-05-07 |
| 32379193 | Fever and pulmonary lesions on computed tomography were the early clinical manifestations, and the patient developed nonproductive cough later. | 2020-05-07 |
| 32379199 | However, our understanding of the clinical characteristics and treatment of critically ill pediatric patients and their ability of transmitting the coronavirus that causes COVID-19 still remains inadequate because only a handful pediatric cases of COVID-19 have been reported. […] Epidemiology, clinical characteristics, treatment, laboratory data and follow-up information and the treatment of critically ill infant were recorded. […] The infant had life-threatening clinical features including high fever, septic shock, recurrent apnea, petechiae and acute kidney injury and persistent declined CD3+, CD4+ and CD8+ T cells. | 2020-05-08 |
| 32379417 | The underlying mechanisms for the olfactory symptoms are unclear. | 2020-05-24 |
| 32379502 | The overall IFR for COVID-19 should be lower when we account for cases that remain and recover without symptoms. | 2020-05-07 |
| 32379592 | Previous researches have presented the common clinical manifestations including respiratory symptoms (i.e., fever and cough), fatigue and myalgia. | 2020-05-07 |
| 32379667 | In this randomized controlled clinical trial, a total of 51 patients who entered the isolation ward were included in the study and randomly divided into experimental and control groups. | 2020-05-11 |
| 32379692 | The Traditional Chinese Medicine is widely used in clinical practice in China, but many other countries of the world to deal with diseases that remain clinically challenging. | 2020-05-11 |
| 32379699 | In patients with clinical insufficiency showing clinical deterioration during an acute COVID-19 infection, we advise immediate (self-)injection of 100mg hydrocortisone intramuscularly, followed by continuous intravenous infusion of 200mg hydrocortisone per 24 hours, or until this can be established, administration of 50mg hydrocortisone every 6 hours. | 2020-05-08 |
| 32379729 | Detailed data on demographic characteristics, underlying medical conditions, and clinical outcomes for persons hospitalized with COVID-19 are needed to inform prevention strategies and community-specific intervention messages. | 2020-05-08 |
| 32379731 | Methods to decrease transmission within the facility include worker symptom screening programs, policies to discourage working while experiencing symptoms compatible with COVID-19, and social distancing by workers. | 2020-05-08 |
| 32379854 | In an effort to ameliorate this devastation, the biomedical research complex has allocated billions of dollars and scientists have initiated hundreds of clinical trials in an expedited effort to understand, prevent, and treat this disease. | 2020-05-08 |
| 32379863 | Unlike targeted SARS-CoV-2 qRT-PCR testing, metagenomic analysis of these SARS-CoV-2 negative samples identified candidate etiological agents for the patients’ respiratory symptoms. | 2020-05-29 |
| 32379882 | Panel members evaluate best available evidence and expert opinion on use of remote and virtual platforms in clinical care, adaptability to alterations in clinic and referral management, and provide guidance on post-graduate impact. […] Several strategies will help address these challenges, including employing telehealth capabilities to continue clinical experiences, and providing trainees with opportunities to continue their professional growth beyond fellowship completion. | 2020-05-29 |
| 32379925 | The patient contracted the SARS-CoV2 infection after a dinner with some friends but fortunately she developed very discrete symptoms including only mild fever and rhinorrhea. […] These findings support the potential role of IL-23p19 inhibitors to counteract the « cytokine storm » triggered by the SARS-CoV2 and which is potentially implicated in the severity of the symptoms 3 . | 2020-05-07 |
| 32380026 | We used patient counts and descriptive statistics to report sociodemographic, system, and clinical outcomes. | 2020-05-23 |
| 32380051 | Given this, based on the Guideline on Diagnosis and Treatment of Coronavirus Disease 2019 in China, the present review summarized the basic information, clinical evidence and published literatures of recommended CPMs against COVID-19. […] The details were thoroughly introduced involving compositions, therapeutic effects, clinical indications, medication history of CPMs and the profiles of corresponding research. […] With regard to infected patients with different stages and syndrome, the preferable potentials and therapeutic mechanism of CPMs were addressed through the comprehensive collection of relevant literatures and on-going clinical trials. […] This study could provide an insight into clinical application and underlying mechanism of recommended CPMs against COVID-19, with the aim to share the Chinese experience in clinical practice and facilitate scientific development of TCM, especially CPMs in the fierce battle of COVID-19. | 2020-05-30 |
| 32380337 | Patient screening was performed only when there were symptoms (57%) and not routinely before surgery (18%). | 2020-05-19 |
| 32380430 | In addition, we retrieved clinical data on patients with cancer and with confirmed COVID-19 in our institution. […] None of the patients receiving immunotherapy experienced severe adverse outcomes, and four patients were discharged with complete reversal of the clinical syndrome and SARS-CoV-2 clearance. […] Any significant work in the design and implementation of health system actions, including clinical care, must be framed as an initiative under the global response agenda and through a community approach, with the intention of pursuing common goals to tackle COVID-19 and cancer, as ‘One Community’ working for ’One Health’s. | 2020-05-29 |
| 32380474 | They should know hyponatraemia symptoms. | 2020-05-08 |
| 32380475 | • Clinical evaluation should guide those needing investigation • Strict adherence to COVID-19 protection measures is necessary • Alternative ways of consultations (telephone, video) should be used • Early discussion with regional/national experts about investigation and management of potential and existing patients is strongly encouraged • Patients with moderate and severe clinical features need urgent investigation and management • Patients with active Cushing’s syndrome, especially when severe, are immunocompromised and social shielding is recommended • In patients with mild features or in whom a diagnosis is less likely, clinical re-evaluation should be repeated at three and six months or deferred until the prevalence of SARS-CoV-2 has significantly decreased • Diagnostic pathways may need to be very different from usual recommendations in order to reduce investigations • When extensive differential diagnostic testing is not feasible, it should be deferred, and medical treatment should be initiated • Transsphenoidal pituitary surgery may be avoided during high SARS-CoV-2 viral prevalence • Medical management rather than surgery will be the used for most patients since the short- to mid-term prognosis depends in most cases on hypercortisolism rather than its cause; it should be initiated promptly to minimize the risk of infection in these immunosuppressed patients. | 2020-05-08 |
| 32380501 | With the outbreak of the COVID-19 pandemia, routine clinical work was immediately, deeply, and sustainably impacted in Germany and worldwide. […] In parallel, routine as well as emergency clinical care for all patients in need has to be secured. […] This includes sustained conduction of clinical trials as well as ongoing translational research. | 2020-05-07 |
| 32380510 | Infected pangolins showed clinical signs and histological changes, and circulating antibodies against Pangolin-CoV reacted with the S protein of SARS-CoV-2. | 2020-05-07 |
| 32380803 | We hereby discuss the challenges faced while approaching any case of shortness of breath, or other common upper respiratory symptoms during the current COVID-19 pandemic era. | 2020-05-11 |
| 32380908 | Overall, after one treatment, patients’ clinical status and oxygenation improved with an average pressure of arterial oxygen to fraction of inspired oxygen ratio (PaO2/FiO2) increase of 192% (P < 0.001). | 2020-05-23 |
| 32381057 | The clinical data including age, sex, exposure history, laboratory parameters and aetiological diagnosis of all patients were collected. […] Older age, symptoms of diarrhoea, exposure history related to Wuhan, and a lower white blood cell and lymphocyte count were significantly suggestive of COVID-19 rather than non-COVID-19 (p < 0.05). | 2020-05-11 |
| 32381073 | Therefore, it is necessary to understand the clinical characteristics of COVID-19 in children and the differences from adults. […] The patient continued to test positive for SARS-CoV-2 RNA in the nasopharyngeal swabs and stool at 17 days after the disappearance of symptoms. […] The present pediatric case of COVID-19 was acquired through household transmission, and the symptoms were mild. […] The RNA of SARS-CoV-2 in stool and nasopharyngeal swabs remained positive for an extended period of time after the disappearance of symptoms. […] This suggests that attention should be given to the potential contagiousness of pediatric COVID-19 cases after clinical recovery. | 2020-05-12 |
| 32381140 | Examples include universal masking of providers and patients; decreasing thresholds to test asymptomatic patients; using face shields and N95 respirators regardless of symptoms and test results; novel additions to the list of aerosol-generating procedures; and more comprehensive personal protective equipment including hair, shoe, and leg covers. | 2020-05-22 |
| 32381147 | Although screening all patients with respiratory symptoms for COVID-19 has been recommended, the practicality of such an effort has yet to be assessed. […] Over a 6-week period during a SARS-CoV-2 outbreak, our institution introduced a “respiratory surveillance ward” (RSW) to segregate all patients with respiratory symptoms in designated areas, where appropriate personal protective equipment (PPE) could be utilized until SARS-CoV-2 testing was done. | 2020-05-28 |
| 32381426 | The clinical, biological and radiological data of the patients who developed a nosocomial infection with SARS-Cov-2 were collected from the computerized medical record. | 2020-05-11 |
| 32381430 | However, overall similarities in the clinical presentation of these dermatological manifestations have not yet been summarized. […] Studies written in the English language that mentioned cutaneous symptoms and COVID-19 were included. […] Skin lesion development occurred before the onset of respiratory symptoms or COVID-19 diagnosis in 12.5% (9/72) of the patients, and lesions spontaneously healed in all patients within 10 days. […] Infection with COVID-19 may result in dermatological manifestations with various clinical presentations, which may aid in the timely diagnosis of this infection. | 2020-05-11 |
| 32381642 | Acute diagnosis of COVID-19 infection is critically dependent on detection of SARS-CoV-2 RNA from clinical specimens (e.g. nasopharyngeal swabs). […] While laboratory-developed testing for SARS-CoV-2 is an essential component of diagnostic testing for this virus, the majority of clinical microbiology laboratories are dependent on commercially available SARS-CoV-2 molecular assays. […] Outside of highly specialized academic and commercial laboratory settings, clinical microbiology laboratories are likely unfamiliar with EUA classification and thus assay verification can be daunting. […] Here, we describe guidance for the verification of assays with EUA for the detection of SARS-CoV-2 nucleic acid from clinical specimens. | 2020-05-08 |
| 32381643 | Taken together, these data imply both platforms can be considered comparable in terms of their clinical performance. | 2020-05-08 |
| 32382001 | Pregnant women seem to had no serious symptoms. | 2020-05-11 |
| 32382146 | Precaution is necessary to prevent possible SARS-CoV-2 infection through ocular surface in clinical practice. | 2020-05-11 |
| 32382213 | Our findings show that across various research domains, and apart from the medical and clinical aspects such as the safety of vaccines and treatments, issues related to patient transport safety, occupational safety of healthcare professionals, biosafety of laboratories and facilities, social safety, food safety, and particularly mental/psychological health and domestic safety have thus far attracted most attention of the scientific community in relation to the COVID-19 pandemic. | 2020-05-11 |
| 32382259 | This report describes measures that can be adopted by oral healthcare personnel to minimize the risk of cross-contamination in clinical practice during the current SARS-CoV-2 pandemic. | 2020-05-11 |
| 32382449 | This study evaluates how the implementation of clinical diagnostics and universal symptom surveys contributed to epidemic control in Wuhan. […] The SEIR+Q dynamics model was fitted using the daily reported number of confirmed infections and unconfirmed cases by clinical diagnostic criteria up to February 14, 2020 in Wuhan. […] Effective reproductive number R(t) analysis using observed frequencies showed a remarkable decline after the implementation of clinical diagnostic criteria and universal symptom surveys, which was significantly below the R(t) curve estimated by the model assuming that the pre-February 14 trend was carried forward. […] The implementation of clinical diagnostic criteria and universal symptom surveys contributed to a contraction in both the magnitude and the duration of the epidemic in Wuhan. | 2020-05-11 |
| 32382463 | However, patients may present with atypical symptoms that pose a diagnostic challenge. | 2020-05-11 |
| 32382743 | Information on demographics, risk factors, and hospital outcomes of cases was obtained through epidemiological investigations and an electronic medical records match, and summarized descriptively. | 2020-05-29 |
| 32382746 | This paper also reports narrative information on the spectrum of symptoms collected directly from the patients. […] It would be difficult to triage patients with COVID-19 based on the typical symptoms of fever and/or cough, although PCR and CT are definitive in diagnosis. | 2020-05-29 |
| 32382748 | Our review summarizes the current knowledge of pediatric clinical disease, role in transmission, risks for severe disease, protective immunity, as well as novel therapies and vaccine trials for children. | 2020-05-29 |
| 32382873 | Clinical trials for future therapies are still ongoing. | 2020-05-11 |
| 32383125 | Currently, there is a lack of evidence-based therapies to prevent COVID-19 following exposure to the virus, or to prevent worsening of symptoms following confirmed infection. […] We describe the design of a clinical trial of hydroxychloroquine for post-exposure prophylaxis (PEP) and pre-emptive therapy (PET) for COVID-19. […] We will conduct two nested multicentre international double-blind randomized placebo-controlled clinical trials of hydroxychloroquine for: 1) PEP of asymptomatic household contacts or healthcare workers exposed to COVID-19 within the past four days, and 2) PET for symptomatic outpatients with COVID-19 showing symptoms for less than four days. | 2020-05-11 |
| 32383179 | We evaluated the concordance between the Roche Diagnostics cobas 6800 SARS-CoV-2 test and a laboratory-developed test (LDT) real-time reverse transcription-polymerase chain reaction based on a modified Centers for Disease Control and Prevention protocol, for the detection of SARS-CoV-2 in samples submitted to the Clinical Laboratories of the Mount Sinai Health System. […] A total of 1006 nasopharyngeal swabs in universal transport medium from persons under investigation were tested for SARS-CoV-2 as part of routine clinical care using the cobas SARS-CoV-2 test with subsequent evaluation by the LDT. | 2020-05-23 |
| 32383183 | The convalescent plasma containing a high level of SARS-CoV-2 immunoglobulin G (IgG) antibody has been used in clinical therapy and achieved good effects in China. | 2020-05-23 |
| 32383234 | Associated symptoms, latency time, treatment, and prognosis were also carefully summarized. | 2020-05-22 |
| 32383239 | The Covid-19 pandemic confronted us with unknown clinical pictures, also in diabetology and endocrinology. […] Sharing clinical experiences is therefore of enormous importance. | 2020-05-25 |
| 32383254 | Taken together, our results confirm that the colorimetric cytopathic effect-based microneutralization assay could be used as a valid clinical test method for epidemiological and vaccine studies. | 2020-05-18 |
| 32383264 | If proven true, this may explain frequent neurological symptoms associated with severe COVID-19 diseases. | 2020-05-08 |
| 32383284 | A 48-year-old woman with a past medical history of migraines and hyperlipidemia presented due to severe retrosternal chest pain with no other associated signs or symptoms. […] To our knowledge, this case is the first in which SCAD has been reported in the LAD in a patient with COVID-19 with no other symptoms of respiratory illness or symptoms classically associated with the novel coronavirus. | 2020-05-08 |
| 32383370 | Initially, acute loss of smell (anosmia) and taste (ageusia) was not considered important symptoms for coronavirus disease 2019 (COVID-19). […] To determine the prevalence of these symptoms and to evaluate their diagnostic significance, we (approximately 150 physicians of the Daegu Medical Association) prospectively collected data of cases of anosmia and ageusia from March 8, 2020, via telephone interview among 3,191 patients in Daegu, Korea. […] The median time to recovery was 7 days for both symptoms. […] Anosmia and ageusia seem to be part of important symptoms and clues for the diagnosis of COVID-19, particularly in the early stage of the disease. | 2020-05-13 |
| 32383530 | Seventy clinical colleagues of the authors were emailed and invited to share their concerns online about how to deliver cognitive-behavioral therapy for eating disorders (CBT-ED) via telehealth, and how to adapt clinical practice to deal with the problems that they and others had encountered. […] A large proportion were general clinical and practical domains (patient and therapist concerns about telehealth; technical issues in implementing telehealth; changes in the environment), but there were also specific considerations and clinical recommendations about the delivery of CBT-ED methods. | 2020-05-08 |
| 32383624 | The hypothesis has been proposed that patients COVID-19 positive, under anti-hypertensive treatment with angiotensin enzyme inhibitors or angiotensin receptor-blockers, might have a worse or a better clinical prognosis. […] However, no solid clinical data are available at the present moment to support or disprove such hypotheses. […] We hope that our letter will encourage other clinical centres, even outside Italy, to join our study. | 2020-05-08 |
| 32383638 | The prolonged persistence of virus RNA in various body fluids may guide the clinical diagnosis and prevention of onward virus transmission. | 2020-05-08 |
| 32383763 | To compare demographic characteristics, clinical presentation, and outcomes of patients with and without concomitant cardiac disease, hospitalized for COVID-19 in Brescia, Lombardy, Italy. | 2020-05-19 |
| 32383778 | Most reports of COVID-19 highlight fever and upper respiratory symptoms as the dominant initial presentations, consistent with the World Health Organization guidelines regarding suspected SARS-CoV-2 infection. […] A 73-year-old man who presented with confusion in the absence of any respiratory symptoms or fever. […] Although he began to experience a spiking fever and mild upper respiratory symptoms, he recovered rapidly with no residual sequela. | 2020-05-16 |
| 32383809 | Data retrieved from electronic medical records regarding symptoms, signs, and laboratory findings on admission, and final outcomes of all older patients with COVID-19, were retrospectively reviewed. […] Univariate analysis revealed that several clinical characteristics and laboratory variables were significantly different (ie, P < .05) between discharged and deceased patients. | 2020-05-12 |
| 32383963 | The purpose of the study is to propose an operating protocol that can be useful for all clinical and forensic autopsies with particular reference to the correct methods to be applied to the examination of positive or suspected COVID-19 cases regarding both the autopsy procedure and the collection and analysis of biological samples. | 2020-05-08 |
| 32384004 | These barriers have altered many aspects of our established workflow and algorithms for care, including changes in communication, goals of care discussions, how providers and nurses are monitoring for symptoms, and end-of-life monitoring. | 2020-05-08 |
| 32384078 | Limited data are available for clinical characteristics of patients with coronavirus disease 2019 (COVID-19) outside Wuhan. […] This study aimed to describe the clinical characteristics of COVID-19 and identify the risk factors for severe illness of COVID-19 in Jiangsu province, China. […] Clinical data of hospitalized COVID-19 patients were retrospectively collected in 8 hospitals from 8 cities of Jiangsu province, China. […] Clinical findings of COVID-19 patients were described and risk factors for severe illness of COVID-19 were analyzed. […] At the onset of illness, the common symptoms were fever (156 [77.2%]) and cough (120 [59.4%]). […] In this case series in Jiangsu Province, COVID-19 patients had less severe symptoms and had better outcomes than the initial COVID-19 patients in Wuhan. | 2020-05-26 |
| 32384153 | The assay showed no cross-reactivity to any other screened coronaviruses or respiratory viruses of clinical significance. | 2020-05-29 |
| 32384159 | We assessed the effectiveness of syndromic screening at departure and/or arrival & traveller sensitisation to the COVID-2019-like symptoms with the aim to trigger rapid self-isolation and reporting on symptom onset to enable contact tracing. | 2020-05-29 |
| 32384180 | Clinical characterization of skin findings was conducted by dermatologists. […] Out of all, 19 patients (79.2%) presented the skin rash after the onset of COVID-19 symptoms. […] This monocentric study shows the clinical characteristics of vesicular skin rashes in COVID-19 patients. | 2020-05-08 |
| 32384251 | Monitoring can be used in particular to gather pandemic data and obtain real-time clinical feedback. | 2020-05-08 |
| 32384397 | Little is known about the risk factors for the clinical outcomes of COVID-19 in children. […] For cases with severe pneumonia caused by COVID-19, the most common symptoms were dyspnea (87.5%), fever (62.5%) and cough (62.5%). | 2020-05-08 |
| 32384412 | The familiarity of radiologists with clinical and imaging manifestations of COVID-19 pneumonia and their prognostic implications is essential to provide optimal care to patients. | 2020-05-08 |
| 32384516 | While several companies have already begun vaccine trials and healthcare facilities have been using a wide-range of medications to treat the virus and symptoms, there is not yet an approved medication regimen for COVID-19 infections. | 2020-05-13 |
| 32384798 | Systemic ozone therapy (OT) could be potentially useful in the clinical management of several complications secondary to SARS-CoV-2. […] (3) Results: In experimental models and the few existent clinical studies, homeostasis of the free radical and antioxidant balance by OT was associated with a modulation of NF-κ B/Nrf2 balance and IL-6 and IL-1β expression. […] Controlled clinical trials are needed. | 2020-05-11 |
| 32384917 | While still little is known on the true efficacy of ECMO in this setting, the natural resemblance of seasonal influenza’s characteristics with respect to acute onset, initial symptoms, and some complications prompt to ECMO implantation in most severe, pulmonary decompensated patients. | 2020-05-13 |
| 32385130 | However, there is limited information about the clinical characteristics of hemodialysis patients with COVID-19 or about interventions to control COVID-19 in hemodialysis centers. […] We reviewed epidemiologic and clinical data of patients with laboratory-confirmed COVID-19 between January 1, 2020 and March 10, 2020. […] After initiating comprehensive interventions-including entrance screening of body temperature and symptoms, universal chest CT and blood tests, and other measures-new patients presenting with COVID-19 peaked at 10 per day on January 30, decreasing to 4 per day on February 11. | 2020-05-09 |
| 32385132 | Therefore, patients with nervous system involvement as the presenting symptoms in the early stage of infection may easily be misdiagnosed and their treatment delayed. | 2020-05-14 |
| 32385568 | Surgeons have had to immediately react to this unprecedented clinical challenge by systematically repurposing surgical wards. […] Strictly segregating patient groups in emergency rooms, non-intensive care wards and operating areas prevents viral spread while adequately training and carefully selecting hospital staff allow them to confidently and successfully undertake their respective clinical duties. | 2020-05-14 |
| 32385614 | At many institutions, the number of telemedicine visits dramatically increased within days following the institution of novel coronavirus pandemic restrictions on in-person clinical encounters. | 2020-05-14 |
| 32385628 | Thirteen studies examining the clinical characteristics of hospitalized COVID-19 patients in China and presenting data on the smoking status were found. | 2020-05-14 |
| 32385648 | To analyse clinical and radiological changes from disease onset to exacerbation in coronavirus infectious disease-19 (COVID-19) patients. […] We reviewed clinical histories of 276 patients with confirmed COVID-19 pneumonia and extracted data on patients who met the diagnostic criteria for COVID-19 severe/fatal pneumonia and had an acute exacerbation starting with mild or common pneumonia. […] Following acute exacerbation, patients were likely to have more clinical symptoms (p < 0.01) and abnormal laboratory changes (p < 0.01). […] There are significant changes in clinical, laboratory, and CT findings in patients from disease onset to exacerbation. […] An increase in the number of involved lobes or an increased CT score from the baseline may predict poor clinical outcomes. […] Combining an assessment of CT changes with clinical and laboratory changes could help clinical teams evaluate the prognosis. […] • An increase in number of involved lobes or an increased CT score from the baseline may predict a poor clinical outcome. […] • Worsened symptoms and abnormal laboratory results are also associated with poor prognosis. | 2020-05-14 |
| 32385672 | To minimize the mortality rate, it becomes prudent to identify symptoms promptly and employ treatments appropriately. […] Even though no cure has been established, multiple clinical trials are underway to determine the most optimal strategy. […] In this comprehensive review, we discuss the impact of COVID-19 on health and the immune system of those affected, reviewing the latest treatment approaches and ongoing clinical trials. | 2020-05-12 |
| 32385712 | While most COVID-19 clinical trials focus on “anti-viral” and “anti-inflammatory” strategies, stimulating inflammation resolution is a novel host-centric therapeutic avenue. […] Importantly, SPMs and sEH inhibitors are currently in clinical trials for other inflammatory diseases and could be rapidly translated for the management of COVID-19 via debris clearance and inflammatory cytokine suppression. | 2020-05-14 |
| 32385829 | In this short communication we aim at describing two ways of off-label use as clinical practice or investigational use. […] There is no international guideline for regulating investigational off-label uses as clinical practice. […] Furthermore, respecting the four ethical principles necessitates codification and strict regulation of off-label uses either as clinical practice or investigational. | 2020-05-14 |
| 32385858 | The mean time period between the onset of COVID-19 symptoms to the appearance of cutaneous lesions was 19.5 days (range 16 - 24). […] The remaining 3 patients had been previously discharged after clinical, analytical and radiologic improvement, and negativization of COVID-19 PCR test. […] However, none of the patients presented recurrence of clinical symptoms of COVID-19. | 2020-05-09 |
| 32385859 | Psoriasis treatment relies on immunosuppression, and although most experts agree that the benefit-to risk-ratio is in favor of maintaining selective biologic therapies, and small molecules such as apremilast, they recommend dismission if severe COVID-19 symptoms occur. | 2020-05-09 |
| 32385891 | In this quick review we have analyzed the mechanisms of action and related infective risk of drugs used for the treatment of immune-mediated and oncologic skin conditions during the daily clinical practice. | 2020-05-09 |
| 32385900 | IJED recognizes the disruptive impacts that COVID-19 has on all activities in our field, including clinical work, teaching, and advocacy, and is committed to supporting authors during this difficult time while striving to publish high-quality research. | 2020-05-09 |
| 32386011 | This document summarizes the epidemiological characteristics, clinical features, imaging examination procedure, imaging findings, CT staging, the value of imaging examination, and the methods for control and prevention of nosocomial infection for COVID-19 during imaging examination. […] Furthermore, it extends the clinical characteristics and imaging manifestations of COVID-19 in children. | 2020-05-13 |
| 32386012 | To design a standardized imaging diagnostic reporting mode for screening coronavirus disease 2019 (COVID-19), and to prospectively verify its effectiveness in clinical practice. […] After systematic training, the radiologist experienced clinical practice for screening CT features. | 2020-05-13 |
| 32386013 | To describe the CT features and clinical characteristics of pediatric patients with coronavirus disease 2019 (COVID-19). […] Clinical history, laboratory examination, and detailed CT imaging features were analyzed. […] Two children presented other symptoms like sore throat and stuffy nose. […] One child showed no clinical symptom. […] Pediatric COVID-19 patients have certain imaging and clinical features as well as disease prognosis. | 2020-05-13 |
| 32386014 | These characteristics are of great value in assisting clinical diagnosis and dynamically observing changes undersuch condition. 目的: 分析2019冠状病毒病不同时期的影像学表现特点，并总结其演变特征。 | 2020-05-13 |
| 32386015 | The improvement time of clinical symptoms and the image changes of follow-up CT were statistically analyzed. […] The changes of CT imaging lesions during follow-up were significantly different in different clinical symptoms improvement time (P< 0.01). […] The change of clinical symptoms is synchronous with the change of reexamination CT. […] Follow-up CT can reflect the trend of clinical changes. […] Repeat CT examination plays an important role in the early clinical diagnosis and the evaluation for the therapeutic effect on COVID-19 patient. 目的: 通过多阶段观察2019冠状病毒病(coronavirus disease 2019，COVID-19)患者的CT影像学表现，研究COVID-19各期CT影像学特征，为临床早期诊断和治疗提供依据。 | 2020-05-13 |
| 32386016 | The clinical data and imaging findings of the first nucleic acid-negative COVID-19 patients were analyzed and compared with the first nucleic acid-positive patients. […] There were no significant differences in the characteristics of the clinical data and radiological findings between the 2 groups (P>0.05). | 2020-05-13 |
| 32386017 | Imaging data of the first chest CT examination and clinical data (age, sex, clinical history, epidemiological history, and laboratory tests) of 163 patients with COVID-19 from 2 hospitals were collected for retrospective analysis. | 2020-05-13 |
| 32386019 | We reported a group of family cluster outbreak cases confirmed in Xiangya Hospital, Central South University, China, and their clinical and image characteristics have been analyzed in order to provide reference for the prevention and early diagnosis of this disease. […] Four adult patients showed different symptoms, including cough, fever, pharyngeal pain, and dyspnea, while the child patient had no symptoms. | 2020-05-13 |
| 32386285 | The systematic literature search returned 31 articles eligible for inclusion in the study and informed our recommendations for clinical assessment and management. | 2020-05-09 |
| 32386433 | While most patients will have mild to moderate symptoms, a subset will become severely ill, with possible complications including respiratory failure and acute respiratory distress syndrome (ARDS). | 2020-05-09 |
| 32386459 | Since the beginning of the pandemic of Coronavirus disease (COVID-19) an increasing number of skin manifestations have been reported.1,2 Most reports concern adult patients and describe various patterns of skin eruptions, in most of cases with low specificity and no univocal temporal association with the onset of systemic symptoms of COVID-19.1-3. | 2020-05-09 |
| 32386460 | Pruritus and mild pain were the only skin symptoms elicited, and only 10 had mild respiratory and/or GI symptoms. […] One out of 16 tested cases had elevated D-dimer results, but without systemic symptoms or other laboratory anomalies. | 2020-05-23 |
| 32386464 | COVID-19 symptoms and mortality are disproportionately more severe in people with obesity and obesity related comorbidities (2, 3). | 2020-05-09 |
| 32386514 | Some randomized clinical trials assessing the effects of different drugs have been published, and more are currently underway. […] We will conduct a living systematic review based on searches of major medical databases (e.g., MEDLINE, EMBASE, CENTRAL) and clinical trial registries from their inception onwards to identify relevant randomized clinical trials. […] We will include randomized clinical trials comparing any intervention for the treatment of COVID-19 (e.g., pharmacological interventions, fluid therapy, invasive or noninvasive ventilation, or similar interventions) with any comparator (e.g., an “active” comparator, standard care, placebo, no intervention, or “active placebo”) for participants in all age groups with a diagnosis of COVID-19. […] Risk of bias will be assessed with domains, an eight-step procedure will be used to assess if the thresholds for clinical significance are crossed, and the certainty of the evidence will be assessed by Grading of Recommendations, Assessment, Development and Evaluations (GRADE). […] This review will continuously inform best practice in treatment and clinical research of this highly prevalent disease. | 2020-05-13 |
| 32386567 | The traditional weight-centric patient-selection criteria do not favour cases based on actual clinical needs. | 2020-05-29 |
| 32386671 | This article summarises the clinical and surgical experience of Maxillofacial Surgery Unit of “Magna Graecia” University (Catanzaro -Italy) during the COVID-19 pandemic and would like to provide a number of recommendations that should facilitate the scheduling process of surgical activities during the COVID-19 pandemic and reduce the risk of infection among healthcare professionals. | 2020-05-14 |
| 32386675 | We did a comprehensive exploration of the epidemiological and clinical characteristics of 136 patients with confirmed COVID-19 in main district of Chongqing which was adjacent to the west of Hubei province. […] Data of patients included demographic, epidemiological, clinical features, chest radiographs of imported cases, local cases, second-generation cases and third-generation cases. […] The median age was 47 years and common symptoms of illness were cough (50.7%), fever (47.1%) and fatigue (14.0%). […] We concluded the epidemiological and clinical characteristics of the cases andsuggested to take more comprehensive measures for screening patients, especially for elderly person, avoid family gatherings, and implement more closely surveillance of suspect patients and their close contacts. | 2020-05-14 |
| 32386804 | Upon admission to the hospital, his clinical condition deteriorates requiring ventilatory support. | 2020-05-14 |
| 32386911 | An expert panel convened to develop initial consensus guidelines regarding anti-neoplastic therapy during the COVID-19 pandemic with respect to gynecologic cancer care and clinical trials. […] In addition, this pandemic will likely strain resources, making delivery of cancer care or conduct of clinical trials unpredictable. […] Deviations will occur in clinical trials as a result of limited resources, and it is important to understand regulatory obligations to trial sponsors as well as to the IRB to ensure that clinical trial and patient safety oversight are maintained. | 2020-05-14 |
| 32386966 | Additionally, all the elective surgeries and non-urgent clinical interventions have also been deferred during this time. | 2020-05-14 |
| 32387014 | Chlorpromazine (CPZ) is a phenothiazine derivative widely used in clinical routine in the treatment of acute and chronic psychoses. […] In comparison to other antiviral drugs, the main advantages of CPZ lie in its biodistribution: (i) preclinical and clinical studies have reported a high CPZ concentration in the lungs (20-200 times higher than in plasma), which is critical because of the respiratory tropism of SARS-CoV-2; (ii) CPZ is highly concentrated in saliva (30-100 times higher than in plasma) and could therefore reduce the contagiousness of COVID-19; (iii) CPZ can cross the blood-brain barrier and could therefore prevent the neurological forms of COVID-19. […] At this end, we designed a pilot, phase III, multicenter, single blind, randomized controlled clinical trial. […] Efficacy of CPZ will be assessed according to clinical, biological and radiological criteria. […] Response to treatment is defined by a reduction of at least one level of severity on the WHO-Ordinal Scale for Clinical Improvement (WHO-OSCI). […] The secondary objectives are to demonstrate in the CPZ+SOC group, compared to the SOC group: (A) superior clinical improvement; (B) a greater decrease in the biological markers of viral attack by SARS-CoV-2 (PCR, viral load); (C) a greater decrease in inflammatory markers (e.g. […] Indeed, CPZ is an FDA-approved drug with an excellent tolerance profile, prescribed for around 70 years in psychiatry but also in clinical routine in nausea and vomiting of pregnancy, in advanced cancer and also to treat headaches in various neurological conditions. […] The discovery of those CPZ properties, as for many other molecules in psychiatry, is both the result of serendipity and careful clinical observations. | 2020-05-14 |
| 32387040 | Sofosbuvir active metabolite, however, shows an extremely high intracellular stability So, it is hypothesized that SARS-CoV-2 infection could also be susceptible to sofosbuvir and we were convinced to design and run a clinical trial to evaluate the effect of sofosbuvir 400 mg (in combination with velpatasvir 100 mg, as add-on treatment, in addition to standard of care) on the COVID-19. | 2020-05-17 |
| 32387041 | This case highlights a problematic ethical double standard in multinational clinical research: trials that would be considered unethical in high income countries (e.g., placebo-controlled where there is an existing treatment) are nonetheless justified in low-and-middle-income countries because the existing standards of care are less (i.e., no access to a treatment). […] Underlying this ethical double standard in some multinational clinical trials is a moral imperialism and persistent colonialist thinking that must be rejected. | 2020-05-14 |
| 32387057 | The initial clinical presentation of coronavirus disease 2019 may be appendicular syndrome. | 2020-05-14 |
| 32387082 | Abdominal pain is one of the known symptoms associated with coronavirus disease 2019. | 2020-05-16 |
| 32387138 | The COVID-19 pandemic requires health care teams to rethink how they can continue to provide high-quality care for all patients, whether they are suffering from a COVID-19 infection or other diseases with clinical uncertainty. | 2020-05-26 |
| 32387139 | Overall, the cohort reflects previously described experiences, with increased frailty (median Clinical Frailty Scale score of 5) and extensive comorbidity burden. | 2020-05-26 |
| 32387238 | Covid-19 is characterized by weak symptoms in most affected patients whilst severe clinical complications, with frequent fatal issues, occur in others. | 2020-05-29 |
| 32387246 | The clinical findings include changes in ECG, cardiac biomarkers, and impaired cardiac function. | 2020-05-14 |
| 32387301 | COVID-19 is a medical emergency, with 20 % of patients presenting with severe clinical manifestations. | 2020-05-30 |
| 32387333 | In view of the pandemic caused by the novel coronavirus (SARS-CoV-2), clinical trials have been designed to examine the effects of inhaled nitric oxide in COVID-19 subjects. | 2020-05-16 |
| 32387384 | The initial phase of the epidemic, from February 17th to March 23rd, 2020, is used to estimate the contact rates, infectious periods and mortality rate using both confirmed cases (by date of symptoms initiation), and daily mortality. | 2020-05-22 |
| 32387409 | Outcomes were death, clinical worsening (transfer to ICU, and >10 day hospitalization) and viral shedding persistence (>10 days). […] Good clinical outcome and virological cure were obtained in 973 patients within 10 days (91.7%). […] A poor clinical outcome (PClinO) was observed for 46 patients (4.3%) and 8 died (0.75%) (74-95 years old). […] A total of 2.3% of patients reported mild adverse events (gastrointestinal or skin symptoms, headache, insomnia and transient blurred vision). | 2020-05-16 |
| 32387456 | Overall, males developed more severe complications, were more frequently hospitalized, and had a worse clinical outcome than females. | 2020-05-14 |
| 32387470 | The severe form of COVID-19 share several clinical and laboratory features with four entities gathered under the term “hyperferritinemic syndromes” and including macrophage activation syndrome (MAS), adult-onset Still’s disease (AOSD), catastrophic anti-phospholipid syndrome (CAPS) and septic shock. | 2020-05-14 |
| 32387575 | The most prevalent symptoms in COVID-19 are breathlessness, cough, drowsiness, anxiety, agitation and delirium. | 2020-05-14 |
| 32387682 | No special factors were found accounting for the presence or absence of symptoms. | 2020-05-14 |
| 32387694 | While few clinical trials have suggested some beneficial effects of CQ and HCQ in COVID-19 patients, most of the reported data are still preliminary. […] Given the current uncertainty, it is worth being mindful of the potential risks and strictly rationalise the use of these drugs in COVID-19 patients until further high quality randomized clinical trials are available to clarify their role in the treatment or prevention of COVID-19. | 2020-05-22 |
| 32387756 | The novel coronavirus Covid-19 follows transmission route and clinical presentation of all community-acquired coronaviruses. […] Children and younger people are almost protected from severe clinical presentation. | 2020-05-14 |
| 32387778 | Given the uncertainty and variation in the input parameters, the model estimated a median range of 171 to 1,090 infected persons in the catchment, which is in reasonable agreement with clinical observations. | 2020-05-19 |
| 32387786 | Necessary adaptations in patient management, triage, and diagnosis are evolving in light of the ongoing scientific and clinical findings. […] Specific recommendations pertaining to clinical practice for neurologists and neurosurgeons have also been provided. | 2020-05-31 |
| 32387924 | The reticular patterns were noted from the 14 days after symptoms onset in 7 of 20 patients (45 %). | 2020-05-27 |
| 32387968 | We evaluated the clinical performance of an immunochromatographic (IC) IgM/IgG antibody assay for severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) and chest computed tomography (CT) for the diagnosis of Coronavirus disease 2019 (COVID-19). | 2020-05-29 |
| 32388117 | Nursing campus courses have also been suspended, and there may be a learning gap between hand hygiene theory and clinical training for nursing students. […] A virtual classroom education approach may help address the learning gap by providing ongoing theoretical strengthening of hand hygiene during clinical nursing training. | 2020-05-29 |
| 32388326 | The search was conducted over clinical trials and literature and systematic reviews on the effects of increasing the aerobic capacity on the function and strength of specific immune and respiratory elements essential for overcoming COVID-19 infections. | 2020-05-27 |
| 32388333 | IoT implementation impacts on reducing healthcare cost and improve treatment outcome of the infected patient. […] IoT is helpful for an infected patient of COVID-19 to identify symptoms and provides better treatment rapidly. | 2020-05-27 |
| 32388390 | Epidemiology, risk factors, and clinical characteristics of patients with COVID-19 have been reported but the factors affecting the immune system against COVID-19 have not been well described. | 2020-05-18 |
| 32388451 | After recovery natalizumab has been administered in the window of the extended interval dosing (EID), without reporting any worsening or new symptoms. | 2020-05-27 |
| 32388458 | All of them had two-week quarantine since documented exposure and none of them developed clinical manifestations of infectious disease. | 2020-05-26 |
| 32388469 | The time from onset of gastrointestinal symptoms to hospital presentation is often delayed compared to that of respiratory symptoms. | 2020-05-29 |
| 32388470 | So far, one of the major drawbacks of the available molecular assays for the diagnosis of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) is the need for viral nucleic acid extraction from clinical specimens. […] Crossreactive analysis performed in 20 nasopharyngeal swabs confirmed a 100% of clinical specificity of the assay. […] Clinical performances of Simplexa™ COVID-19 Direct assay were assessed in 278 nasopharyngeal swabs tested in parallel with Corman’s method. | 2020-05-29 |
| 32388471 | Analytical performance was evaluated using in-vitro transcribed RNA and clinical performance was compared to the cobas 6800-based reference assay within the lab. […] The E-Gene-LDT showed analytical and clinical performance comparable to the cobas6800-based reference assay. […] Due to its random-access workflow concept and rapid time-to-result of about 80 min, the system is very well suited for providing fast-tracked SARS-CoV-2 diagnostics for urgent clinical samples in the hospital setting. | 2020-05-29 |
| 32388472 | To describe the clinical manifestations and epidemiological characteristics of patients with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in Hunan Province in 2020. […] These patients are early mild cases, most common symptoms are fever [23 (70 %)] and cough [13 (39 %)]. […] The clinical symptoms, laboratory results and imaging reports of patients with COVID-19 in Hunan area are significantly different from those in Wuhan area. […] For non-Wuhan epidemic areas, more attention should be paid to nucleic acid test results of throat swabs and stools, and it is not easily to diagnose based on clinical symptoms and CT results. | 2020-05-29 |
| 32388486 | The pandemic calls for rapid mobilization of every potential clinical tool, including phototherapy-one of the most effective treatments used to reduce the impact of the 1918 “Spanish influenza” pandemic. […] These findings call for urgent efforts to further explore the clinical value of light, and not wait for another pandemic to serve as a reminder. | 2020-05-27 |
| 32388698 | These evidences further emphasize the new era of gBRCA testing in the management of cancer patients and confirms definitively the integration of gBRCA testing/Next Generation Sequencing (NGS) into clinical oncology. […] Finally, a re-organization of gBRCA testing in our Unit, mainly related to delayed and reduced arrival of tests was necessary, ensuring, however, a high-quality standard and reliability, mandatory for gBRCA testing in a clinical setting. | 2020-05-14 |
| 32388722 | Moreover, child’s will must not be forced.Conclusion: On the basis of clinical findings, we think that the universal use of facial masks seems necessary when people have to go out in their everyday lives. | 2020-05-14 |
| 32388805 | Although these historical reports are of low-level evidence per se, hampering recommendations for decision-making in the clinical setting, they indicate effectiveness in the dose range between 0.3 and 1 Gy, similar to more recent dose concepts in the treatment of acute and chronic inflammatory/degenerative benign diseases with, e.g., a single dose per fraction of 0.5 Gy. […] This concise review aims to critically review the evidence for low-dose radiation treatment of COVID-19 pneumopathy and discuss whether it is worth investigating in the present clinical situation. | 2020-05-14 |
| 32388880 | We describe the case of a 54-years-old Caucasian female patient with typical clinical and electrophysiological manifestations of AIDP, who was reported positive with PCR for SARS-CoV-2, 3 weeks prior to onset of the neurological symptoms. […] She did not experience a preceding fever or respiratory symptoms, but a transient loss of smell and taste. […] The neurological symptoms improved significantly during treatment with immunoglobulins. […] Our case draws attention to the occurrence of GBS also in patients with COVID-19 (coronavirus disease 2019), who did not experience respiratory or general symptoms. […] It emphasizes that SARS-CoV-2 induces immunological processes, regardless from the lack of prodromic symptoms. | 2020-05-26 |
| 32388937 | Objective: To evaluate the efficacy and safety of lopinavir/ritonavir (LPV/r) and arbidol in the treatment of COVID-19 in the real world. Methods: The clinical data of 178 patients diagnosed with COVID-19 admitted to Guangzhou Eighth People’s Hospital were retrospectively analyzed from January 21 to February 9, 2020. […] There was also no significant difference in the rate of negative conversion rate of 2019-nCoV nucleic acid, the improvement ration in clinical symptoms, and the improvement ration of pulmonary infection in the lung CT imaging (P> 0.05). […] Moreover, the frequency of adverse reactions in the three groups receiving antiviral drugs was significantly higher than that in the conventional treatment group (χ(2) = 14.875, P = 0.002). Conclusions: No evidences could prove that LPV/r and arbidol could shorten the negative conversion time of novel coronavirus nucleic acid in pharyngeal swab nor improve the symptoms of patients. | 2020-05-10 |
| 32388947 | The epidemiological history and clinical characteristics of 7 cases of COVID-19 and 1 case of close contact in the first family aggregation epidemic of COVID-19 in Gansu Province were analyzed. | 2020-05-12 |
| 32389027 | This retrospective observational study of laboratory-confirmed COVID-19 adults evaluated glycemic and clinical outcomes in patients with and without diabetes and/or acutely uncontrolled hyperglycemia hospitalized March 1 to April 6, 2020. | 2020-05-21 |
| 32389148 | We aimed to assess outbreak-related psychological distress and symptoms of acute stress reaction (ASR) in health professional students and to characterize individuals with potential need for interventions. […] Our findings suggest that COVID-19 related psychological distress and high symptoms burden of ASR are common among health professional students. | 2020-05-16 |
| 32389195 | Between Feb 7 and April 5, 2018, we visited 228 health facilities, and observed at least one infection prevention and control indication in 220 facilities (118 [54%] dispensaries, 66 [30%] health centres, and 36 [16%] hospitals). 18 710 indications were observed across 734 health workers (49 [7%] medical doctors, 214 [29%] assistant medical officers or clinical officers, 106 [14%] nurses or midwives, 126 [17%] clinical assistants, and 238 [32%] laboratory technicians or assistants). […] For hand hygiene, nurses and midwives (odds ratio 5·80 [95% CI 3·91-8·61]) and nursing and medical assistants (2·65 [1·67-4·20]) significantly outperformed the reference category of assistant medical officers or clinical officers. | 2020-05-27 |
| 32389373 | The clinical characteristics and radiological findings (chest radiography and chest computed tomography [CT]) of nine children infected with the 2019-nCoV were reviewed in this retrospective case series. […] The clinical manifestations and radiological findings of the 2019-nCoV-infected children were mild and lacked a typical pattern. | 2020-05-29 |
| 32389499 | The aging process is characterized by the gradual development of a chronic subclinical systemic inflammation (inflamm-aging) and by acquired immune system impairment (immune senescence). […] Here, we advance the hypothesis that four well-recognized features of aging contribute to the disproportionate SARS-CoV-2 mortality suffered by elderly men: i. the presence of subclinical systemic inflammation without overt disease, ii. a blunted acquired immune system and type I interferon response due to the chronic inflammation; iii. the downregulation of ACE2 (i.e. the SARS-CoV-2 receptor); and iv. accelerated biological aging. | 2020-05-29 |
| 32389518 | It collects epidemiological variables, contagion and diagnosis data, signs and symptoms, treatments and outcomes. […] Patients were diagnosed with SARS-CoV-2 infection based on the results of the PCR of the virus, carried out both in patients who had manifested compatible symptoms or had suspicious signs, as well as in those who had undergone screening after some contact acquainted with another patient. […] Symptoms are similar to the general population. | 2020-05-14 |
| 32389615 | Clinical advice on the management of psychosis during the outbreak needs to be based on the best available evidence. […] Clinical management of these patients, where adherence with infection control procedures is paramount, was challenging. […] Increased vigilance for psychosis symptoms in patients with COVID-19 is warranted. | 2020-05-15 |
| 32389720 | The clinical significance of this observation is unclear; however, the magnitude of this mechanism of drug accumulation via ion-trapping in lysosomes could be an important factor for the pharmacodynamic effects of this drug combination. | 2020-05-15 |
| 32389847 | The clinical picture of COVID-19 suggests a role of ACE2 blockade, rather than its overexpression, in causing the pathogenesis. […] Unfortunately, these agonists have not been tested in clinical studies. | 2020-05-31 |
| 32389849 | In the review, we draw upon the lessons learnt from SARS in the epidemiology, clinical characteristics and pathogenesis for further understand the features of COVID-19. […] Children started with gastrointestinal symptoms may progress to severe condition and newborn whose mother was infected with COVID-19 could have severe complications. | 2020-05-14 |
| 32389999 | CONCLUSIONS There are psychological symptoms and sleep symptoms in front-line medical staff who participate in the fight against COVID-19, and they affect each other. […] Hospitals should improve emergency management measures, strengthen psychological counseling for clinical front-line medical staff, strengthen exercise intervention, and improve their sleep quality and mental health. | 2020-05-12 |
| 32390064 | Here we attempt to coalesce the key knowledge of SARS-CoV-2 biology to the disease and clinical care concepts in the context of older adults. | 2020-05-15 |
| 32390091 | We aimed to report the clinical characteristics of 194 cases coronavirus disease-19 (COVID-19) in Huanggang, Hubei and Taian, Shandong. […] We retrospectively investigated the clinical, laboratory characteristics and CT imaging of confirmed cases of COVID-19 from January 22 to February 28, 2020 in Huanggang Central Hospital and The Second Affiliated Hospital of Shandong First Medical University. […] The average preclinical period was 7.44 day. […] Except for 37 severe or critically ill patients, the rest of the 157 patients exhibited mild or moderate symptoms. […] The main clinical symptom of the patients were fever, sore throat and cough, which accounted for 146 cases (75.26%), 98 (50.52%) and 86 cases (44.33%), respectively. 30 patients (15.46%) showed liver dysfunction. […] Clinical symptoms, laboratory tests and CT imaging should be combined for comprehensive analysis to diagnose COVID-19. | 2020-05-15 |
| 32390279 | With the increasing involvement of dermatologist in management of this crisis, cutaneous symptoms gained more and more attention. […] In this review, we will describe cutaneous symptoms of patients of all ages in association with COVID-19. […] Although more systematic investigations are warranted, it becomes clear that some symptoms are clinical signs of a milder COVID-19 course, while others are a red flag for a more severe course. | 2020-05-30 |
| 32390285 | International studies describing COVID-19 in children have shown low proportions of paediatric cases and generally a mild clinical course. […] We recorded epidemiological and clinical data. | 2020-05-11 |
| 32390367 | Although some information on the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and a few selected cases has been reported, data on the clinical characteristics and outcomes of patients hospitalized therewith in South Korea are lacking. […] Here, we report the clinical characteristics and laboratory findings of SARS-CoV-2 patients in South Korea up to March 29, 2020. | 2020-05-12 |
| 32390368 | This article mainly summarized the causes, clinical manifestations and preventive measures of COVID-19 impact on psychology of Chinese people, and presented two representative cases at the same time. | 2020-05-12 |
| 32390495 | At the end of the day, vascular access creation is the lifeline of haemodialysis patients and the indication for surgery warrants patient-specific clinical judgement rather than ‘group labelling’. | 2020-05-11 |
| 32390694 | Informed consent has become a challenging issue when surgery at the time of novel corona virus disease 2019 (COVID-19) is to be performed, in view of increased risk of the need of intensive care unit (ICU) in the post-operative period and the associated high mortality if a patient exhibits COVID-19 symptoms in the post-operative period. | 2020-05-15 |
| 32390971 | Multiple ongoing clinical trials for vaccines and antivirals against CoVs showcase the availability of medical interventions to both prevent and treat the future emergence of highly pathogenic CoVs in human. | 2020-05-15 |
| 32391234 | We describe the clinical presentation of this patient, the diagnostic process, the laboratory and imaging investigations, as well as the course of treatment. | 2020-05-15 |
| 32391242 | To apply PM premises in an emerging coronavirus pandemic acquires potentially greater relevance in order to allow the selection of specific preventive measures as well as biomarkers that will be useful in disease management. […] Better understanding of pathogenic pathways together with an accurate phenotype classification of patients presented with SARS-CoV-2 infection and symptoms might contribute to a more accurate definition of biomarkers and other diagnostic tools, which may lead to more precise mitigation strategies, personalized pharmacologic options, as well as new biological therapy developments. | 2020-05-15 |
| 32391282 | Potential risks associated with COVID-19 infection should be considered, considering tumor histology and natural course, disease setting, clinical conditions, and disease burden, together with the expected benefit, toxicities (e.g., myelosuppression or interstitial lung disease), and response obtained from the planned or ongoing treatment. […] Proactive management and containment measures, applied in a structured and daily way, has significantly aided the identification of advance patients with suspected symptoms related to COVID-19, limiting their admission to our cancer center; we have thus been more able to protect other patients from possible contamination and at the same time guarantee to the suspected patients the immediate treatment and evaluation in referral hospitals for COVID-19. | 2020-05-15 |
| 32391309 | Currently, more information is needed so as to further understand the transmission and clinical characteristics of 2019-nCoV infection and the infection control procedures required. | 2020-05-15 |
| 32391369 | Two studies reported negative findings regarding the use of corticosteroids in patients with COVID-19, i.e., corticosteroids had a detrimental impact on clinical outcomes. […] One study reported no significant association between the use of corticosteroids and clinical outcomes. | 2020-05-15 |
| 32391441 | Second, multi-sectoral efforts to offer incentives for those with no or minor symptoms to seek care and to quarantine themselves are critical, which would need concerted efforts from payers, providers, and public health. | 2020-05-15 |
| 32391444 | Our institution and radiation oncology department have used telemedicine services for many years; we would like to report on our departmental experience to guide other radiation oncology practices on its long-term use for clinical evaluation and patient care. […] Our institution’s telemedicine program provides clinical services for a number of remote locations and represents the largest telehealth network in the world, with over 300 sites and 60,000 patient encounters a year. | 2020-05-15 |
| 32391518 | Hospitalized infants were also assessed for clinical signs and symptoms, including fever, cough, and nasal congestion. […] None of the infants tested positive for SARS-CoV2 on days of life 1 through 5, and none demonstrated symptoms of COVID-19 infection. […] While there were no clinical signs of vertical transmission, our findings raise the possibility of intrapartum viral exposure. | 2020-05-11 |
| 32391519 | To describe the clinical course of severe and critical infection in hospitalized pregnant women with positive laboratory testing for SARS-CoV2. […] The clinical courses are described by the median disease day on which these outcomes occurred after the onset of symptoms. […] Gestational age at symptom onset was at a mean 29 ±6 weeks and at hospital admission a mean of 30 ±6 weeks, on a median day of disease 7 since first symptoms. | 2020-05-11 |
| 32391651 | Others do not show any symptoms, but can still contribute to transmission of the virus. | 2020-05-25 |
| 32391657 | The diagnosis of COVID-19 is largely based on the epidemiological evidence and clinical manifestations, and confirmed by positive detection of virus nucleic acid in respiratory samples. […] The main symptoms of COVID-19 in children are fever and cough; the total number of white blood cell count is usually normal or decreased; the chest imaging is characterized by interstitial pneumonia, which is similar to other respiratory virus infections and Mycoplasma pneumoniae infections. […] Early identification, early isolation, early diagnosis and early treatment are important for clinical management. | 2020-05-12 |
| 32391658 | As the National Clinical Research Center for Infectious Diseases, the First Affiliated Hospital of Zhejiang University School of Medicine is the primary medical care center for COVID-19 in Zhejiang province. […] Based on the present expert consensus carried out by National Health Commission and National Administration of Traditional Chinese Medicine, our team summarized and established an effective treatment strategy centered on “Four-Anti and Two-Balance” for clinical practice. […] The importance of early viralogical detection, dynamic monitoring of inflammatory indexes and chest radiograph was emphasized in clinical decision-making. | 2020-05-12 |
| 32391663 | The chest CT images of patients with COVID-19 have certain characteristics with dynamic changes, which are of value for monitoring disease progress and clinical treatment. | 2020-05-12 |
| 32391664 | To investigate the CT findings of patients with different clinical types of coronavirus disease 2019 (COVID-19). […] A total of 67 patients diagnosed as COVID-19 by nucleic acid testing were collected and divided into 4 groups according to the clinical stages based on Diagnosis and treatment of novel coronavirus pneumonia (trial version 6). […] The CT imaging characteristics were analyzed among patients with different clinical types. […] CT images of patients with different clinical types of COVID-19 have characteristic manifestations, and solid shadow may predict severe and critical illness. | 2020-05-12 |
| 32391665 | To explore the risk factors of anxiety and depression in patients with suspected coronavirus disease 2019 (COVID-19) so as to achieve early intervention and better clinical prognosis. […] Their clinical baseline data were collected. | 2020-05-12 |
| 32391666 | The clinical data of 48 patients with suspected COVID-19 admitted in Jinhua Municipal Central Hospital from January 21, 2020 to March 20, 2020 were retrospectively analyzed. | 2020-05-12 |
| 32391667 | We prospectively enrolled 30 treatment-naïve patients with confirmed COVID-19 after informed consent at Shanghai Public Health Clinical Center. […] This study has been approved by the Ethics Committee of Shanghai Public Health Clinical Center and registered online (NCT04261517). | 2020-05-12 |
| 32391668 | In the absence of effective antiviral drugs, early use of appropriate doses of corticosteroids in critically ill patient with COVID-19 can quickly alleviate inflammatory response and improve clinical symptoms, however, it may reduce the number of T cells, and to adjust the dose in time is necessary. | 2020-05-12 |
| 32391669 | To observe the clinical effect of plasma exchange and tocilizumab in treatment of patients with severe coronavirus disease 2019 (COVID-19). | 2020-05-12 |
| 32391671 | To analyze the clinical characteristics and pregnancy outcomes of pregnant women complicated with coronavirus disease 2019 (COVID-19). […] The clinical data of 3 pregnant women with COVID-19 admitted to the First Affiliated Hospital of Zhejiang University School of Medicine from January 19 to February 10, 2020 were retrospectively analyzed. | 2020-05-12 |
| 32391672 | The management and clinical outcome of a sigmoid cancer patient with COVID-19 were analyzed. | 2020-05-12 |
| 32391676 | To investigate the clinical outcome of patients with moderate type of coronavirus disease 2019 (COVID-19) after discharge by retesting viral nucleic acid. […] During the quarantined period, the symptoms and signs were documented, and sputum or nasal swab and feces samples were collected to test SARS-CoV-2 nucleic acid by RT-PCR method. […] There was no symptoms and signs during the quarantine period in all 7 patients. | 2020-05-12 |
| 32391719 | Given the crucial importance of this issue for clinical cardiologists and all specialists dealing with coronavirus disease 19, we tried to recapitulate the current evidence and provide some practical recommendations. | 2020-05-15 |
| 32391741 | Purpose To investigate patients with primary non-respiratory symptoms who underwent abdomen/pelvis or cervical spine/neck CT with unsuspected findings highly suspicious for pulmonary COVID-19. […] Patients without known COVID-19 were included who presented to the emergency room (ER) with primary non-respiratory [gastrointestinal (GI) or neurological] symptoms, had lung parenchymal findings suspicious for COVID-19 on a non-chest CT but no concurrent chest CT and had COVID-19 testing in the ER. […] Cough and fever were more common in group 1 (37/62, 60%, 29/62, 47%) than group 2 (9/57, 16%, 12/57, 21%) respectively, with no significant difference in the remaining symptoms. […] Conclusion In a substantial percentage of patients with primary non-respiratory symptoms who underwent non-chest CT, the CT provided the first evidence of COVID-19 related pneumonia. | 2020-05-11 |
| 32391742 | Medical records were reviewed for clinical data. | 2020-05-11 |
| 32391746 | Over a 16-week surveillance period, we detected 14 cases of COVID-19 among HCWs with ARI symptoms. […] With ongoing local transmission, vigilance must be maintained for intrahospital spread in nonclinical areas where social mingling of HCWs occurs. […] Because most individuals with COVID-19 have mild symptoms, addressing presenteeism is crucial to minimize potential staff and patient exposure. | 2020-05-28 |
| 32391877 | To investigate the characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 (COVID-19). […] Clinical, laboratory, and treatment data were collected and compared between patients who died and survivors. | 2020-05-29 |
| 32391997 | At admission 61% of patients had fever and about 50% presented at day 6 or more after onset of symptoms. | 2020-05-20 |
| 32391998 | Demographic characteristics of patients, clinical presentation and course of disease up to the moment of analysis showed similarity with what has been described in Chinese and Italian literature. […] However the higher proportion of patients presenting with gastro-intestinal symptoms and the high number of patients with overweight and obesity stood out. | 2020-05-20 |
| 32392009 | To describe disease presentation and clinical characteristics of patients with COVID-19 presenting to the Emergency Department (ED) of Bernhoven hospital in Uden, the Netherlands. […] The registry focused on atypical symptoms and co-infections. […] We hypothesized that patients older than 70 years more often have atypical symptoms. […] Therefore, we prospectively registered medical history, duration of symptoms, symptoms, temperature, lab results and co-infections of patients with confirmed COVID-19 in the period March 4-16th. […] The clinical characteristics of 107 patients were registered. […] The median duration of symptoms was 5 days. 19% of patients had not been referred to pulmonary or internal medicine. […] Symptoms were fever (78%), respiratory complaints (78%), chest pain (28%), abdominal pain (13%), and diarrhea (34%). […] Over 35% of patient did not have the typical symptoms of fever and respiratory complaints; atypical symptoms like chest pain, abdominal pain and diarrhea are frequently seen. […] COVID-19 patients can present with atypical symptoms, co-infections and distributed over various medical specialties. | 2020-05-20 |
| 32392017 | Clinical studies, reviews, and guidelines were selected and reviewed by all authors and discussed by internet conference and email. […] A triage algorithm based on clinical estimations of the incremental survival benefit (saving the most life-years) provided by ICU care is proposed. “First come, first served” is used to choose between individuals with equal priorities and benefits. […] Although the algorithm improves consistency and provides practical and psychologic support to those performing triage, the final decision remains a clinical one. | 2020-05-15 |
| 32392072 | Furthermore, we demonstrate the binding poses of three viral RdRp inhibitors (Galidesivir, Favipiravir, and Penciclovir), which were recently reported to have clinical significance for SARS-CoV-2. | 2020-05-23 |
| 32392125 | Although 5 participants had no or mild symptoms, 6 had typical coronavirus disease, without dyspnea. | 2020-05-11 |
| 32392129 | Real-time RT-PCR was used to detect viral RNA from a throat+nose self-swab. 3% of HCWs in the asymptomatic screening group tested positive for SARS-CoV-2. 17/30 (57%) were truly asymptomatic/pauci-symptomatic. 12/30 (40%) had experienced symptoms compatible with coronavirus disease 2019 (COVID-19) >7 days prior to testing, most self-isolating, returning well. […] Our data demonstrates the utility of comprehensive screening of HCWs with minimal or no symptoms. | 2020-05-11 |
| 32392280 | To evaluate early lessons from a remote patient monitoring engagement and education technology solution for patients with COVID-19 symptoms. […] A COVID-19-specific remote patient monitoring solution (GetWell Loop) was offered to patients with COVID-19 symptoms. […] Between March 18 and April 20, 2020, 2,255 of 3,701 (60.93%) patients with COVID-19 symptoms enrolled resulting in over 2,303 alerts, 4,613 messages, 13 hospital admissions, and 91 emergency room visits. […] Remote patient monitoring appears to be an effective approach for managing COVID-19 symptoms at home. | 2020-05-29 |
| 32392282 | To describe the association between use of hydroxychloroquine, with or without azithromycin, and clinical outcomes among hospital inpatients diagnosed with COVID-19. […] Medications, preexisting conditions, clinical measures on admission, outcomes, and adverse events were abstracted from medical records. | 2020-05-20 |
| 32392288 | To provide an early description and characterization of COVID-19 infection in North American PICUs, focusing on mode of presentation, presence of comorbidities, severity of disease, therapeutic interventions, clinical trajectory, and early outcomes. […] Prehospital characteristics, clinical trajectory, and hospital outcomes of children admitted to PICUs with confirmed COVID-19 infection. […] Forty patients (83%) had significant preexisting comorbidities; 35 (73%) presented with respiratory symptoms and 18 (38%) required invasive ventilation. | 2020-05-11 |
| 32392331 | Epidemiological, demographic and clinical data (when available) were collected. | 2020-05-29 |
| 32392334 | Clinicians - eager to offer the best care in the absence of guiding data - have provided patients with COVID-19 diverse clinical interventions. […] Moving forward, randomized controlled clinical trials (RCTs) are necessary to ensure that clinicians can treat patients effectively during this outbreak and the next. | 2020-05-29 |
| 32392337 | We aimed to understand the infection rate, clinical presentation, clinical outcomes and transmission dynamics for SARS-CoV-2, in order to inform clinical and public health measures. […] Data on clinical outcomes are scarce but include several reports of asymptomatic infection and a milder course of disease in young children, though radiological abnormalities are noted. | 2020-05-29 |
| 32392351 | In the current climate, we sought to develop a novel and entertaining online educational method for introducing pre-clerkship students to common clinical presentations in neurology. | 2020-05-11 |
| 32392354 | COVID-19 has disrupted medical education on an international scale with clinical attachments cancelled, assessments and teaching moved online, and numerous universities graduating their final year medical students early to assist pressured health systems. | 2020-05-11 |
| 32392389 | We studied the clinical course of COVID-19 in five hospitalized patients with autoimmune MG (four with acetylcholine receptor antibodies, one with muscle-specific tyrosine kinase antibodies) between April 1, 2020-April 30-2020. […] Our findings suggest that the clinical course and outcomes in patients with MG and COVID-19 are highly variable. | 2020-05-22 |
| 32392431 | Today, in the United States, we have a health care system that is designed to treat symptoms, not people-and to do so as cheaply as possible with the dual goals of minimizing costs and preventing hospital visits. | 2020-05-18 |
| 32392559 | An important distinction is the prevalence of “exposure” versus “clinical infectivity,” which determine the risk versus benefit of modifying potentially highly curative therapies in leukemia. […] At present, the rate of clinical infection is <1-2% worldwide. | 2020-05-11 |
| 32392562 | Since the combination of MTX and baricitinib leads to outstanding clinical outcomes, the addition of baricitinib to MTX might be a potential strategy. | 2020-05-11 |
| 32392591 | Clinical course in children below the age of 10 years is considered to be mild or even with subclinical signs (Sinha IP, Ha et al. | 2020-05-11 |
| 32392741 | The aim of our study was to describe the basic clotting parameters in COVID-19 patients and their prognostic role in different clinical forms of the disease. […] Fibrinogen seems to increase early in COVID-19 patients and may be used as a risk stratification marker for the early detection of a subgroup of COVID-19 patient at increased risk to develop SARS, who might benefit from a different and thorough clinical surveillance and treatment. | 2020-05-12 |
| 32392859 | Severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2) is a novel viral infection characterized by several symptoms range from mild to severe clinical conditions that could lead to death. | 2020-05-12 |
| 32392948 | Objective: To investigate the application of pulmonary ultrasound in the diagnosis of neonatal COVID-19. Methods: In this retrospective study, the clinical data of 5 infants, who were admitted to the Department of Neonatology in Wuhan Children’s Hospital from 31(st) January to 25(th) February 2020, were collected. […] The main clinical manifestations were respiratory and gastrointestinal symptoms. | 2020-05-13 |
| 32393105 | While some surgical cases of laryngotracheal stenosis may be deferred, patients with significant airway obstruction or progressing symptoms often require urgent surgical intervention. | 2020-05-12 |
| 32393325 | To achieve sustainable ICU services, we propose the need to 1) prepare and implement rapid identification and isolation protocols, and a surge in ICU bed capacity; (2) provide a sustainable workforce with a focus on infection control; (3) ensure adequate supplies to equip ICUs and protect healthcare workers; and (4) maintain quality clinical management, as well as effective communication. | 2020-05-13 |
| 32393346 | A significant proportion of individuals infected with COVID-19 may not have symptoms, raising the likelihood of transmission of the disease to inadequately protected health care workers from patients who do not have probable or confirmed infection. | 2020-05-14 |
| 32393381 | Perceived causes of infection, infection prevention, control knowledge and behaviour, psychological changes, symptoms and treatment were measured. […] The top three first symptoms displayed before diagnosis were fever (41.8%), lethargy (33.0%) and muscle aches (30.1%). […] Arbidol (Umifenovir; an anti-influza drug; 69.2%) was the drug most commonly used to target infection in mild and moderate symptoms. | 2020-05-14 |
| 32393438 | The method is a powerful tool for studying the underlying mechanism of platelet aggregation and is expected to open a window on an entirely new class of clinical diagnostics, pharmacometrics, and therapeutics. | 2020-05-14 |
| 32393446 | The lockdown declared to prevent the spread of Covid 19 in India created unforeseen problems, including severe alcohol withdrawal symptoms and the need to manage them. | 2020-05-14 |
| 32393448 | This is cause for concern with regard to bioethics and good clinical practice. […] The evidence for the efficacy of chloroquine and hydroxychloroquine is currently derived from open label trials and cell culture studies with no conclusive evidence available from randomised clinical trials. | 2020-05-14 |
| 32393482 | The SARS-CoV-2 pandemic has caused a severe international shortage of the nasopharyngeal swabs that are required for collection of optimal specimens, creating a critical bottleneck blocking clinical laboratories’ ability to perform high-sensitivity virological testing for SARS-CoV-2. […] We performed a multi-step preclinical evaluation on 160 swab designs and 48 materials from 24 companies, laboratories, and individuals, and shared results and other feedback via a public data repository (http://github.com/rarnaout/Covidswab/) We validated four prototypes through an institutional review board (IRB)-approved clinical trial that involved 276 outpatient volunteers who presented to our hospital’s drive-through testing center with symptoms suspicious for COVID-19. | 2020-05-20 |
| 32393593 | Based on existing clinical data and experience with similar viruses such as influenza and SARS-CoV, the management approach in the context of COVID-19 should, ideally, take into consideration the overall presentation as well as the trajectory of illness. | 2020-05-12 |
| 32393594 | Flu-like symptoms with dyspnea may distinguish COVID-19 infection from dyspnea due to a COPD-related exacerbation. | 2020-05-12 |
| 32393664 | Because the therapeutic window for hydroxychloroquine in the setting of SARS-CoV-2 is unknown, well-designed clinical trials that include patients with rheumatic disease are urgently needed to characterize the efficacy, safety, and target exposures for hydroxychloroquine. | 2020-05-12 |
| 32393767 | However, there is a paucity of further guidance for people with spinal cord injury (SCI) who may not present with typical symptoms of COVID-19 due to altered physiology. | 2020-05-15 |
| 32393804 | A total of 2,618,862 participants reported their potential symptoms of COVID-19 on a smartphone-based app. […] A model combining symptoms to predict probable infection was applied to the data from all app users who reported symptoms (805,753) and predicted that 140,312 (17.42%) participants are likely to have COVID-19. | 2020-05-12 |
| 32393985 | These primary predictive biotargets may potentially be used to treat sepsis in future clinical practice. | 2020-05-12 |
| 32394237 | Interestingly, the patient had no symptoms or signs of infection and also had no risk factors for thromboembolism. | 2020-05-15 |
| 32394338 | For anesthesiologists deployed to units caring for patients with COVID-19, this narrative review provides guidance on conducting goals of care discussions, withdrawing life-sustaining measures, and managing distressing symptoms. | 2020-05-15 |
| 32394344 | This case series of 33 PLWH patients with COVID-19 reveals symptoms and outcome in this special population. […] Retrospective analysis of anonymized data including age, gender, HIV-associated parameters, symptoms, and outcome. | 2020-05-15 |
| 32394467 | Ribavirin reduces hemoglobin concentrations in respiratory patients, and remdesivir improves respiratory symptoms. […] Favipiravir increases clinical recovery and reduces respiratory problems and has a stronger antiviral effect than LPV/r. currently, appropriate treatment for patients with COVID-19 is an ACE2 inhibitor and a clinical problem reducing agent such as favipiravir in addition to hydroxychloroquine and corticosteroids. | 2020-05-12 |
| 32394605 | An online survey was sent to both member and non-member dental schools to investigate the impact on non-clinical and clinical education, assessment and the well-being/pastoral care measures implemented. | 2020-05-12 |
| 32394650 | The outcomes included the symptoms changes, e.g. anxiety, emotional disturbance, fatigue, headache and diarrhea, as well as whether quarantine release and the case confirmed or not, etc. | 2020-05-13 |
| 32394687 | Prompt diagnosis of COVID-19 is essential to prevent disease transmission and provide close clinical observation of patients with clinically severe disease. | 2020-05-12 |
| 32394986 | The precise measurement with the appropriate clinical and epidemiological indicators associated with COVID-19 is a necessary step in reducing the individual and population burden of the current pandemic. […] The options include returning to clinical care or resorting to online textbooks and resources for accelerated courses on the research of outbreaks. | 2020-05-12 |
| 32395064 | In the absence of actual data on cancer surgery care during this pandemic, clinical decisions should be based on careful consideration of disease-related and patient-related factors. | 2020-05-15 |
| 32395417 | This review intends to discuss the symptoms, prevention, and management carried out related to the coronavirus, while also providing the healthcare provider strategies used by different countries in combating the disease. | 2020-05-15 |
| 32395418 | Current clinical management includes infection prevention and control measures and supportive care including supplemental oxygen and mechanical ventilatory support. […] Evolving research and clinical data regarding the virologic SARS-CoV-2 suggest a potential list of repurposed drugs with appropriate pharmacological effects and therapeutic efficacies in treating COVID-19 patients. | 2020-05-15 |
| 32395423 | We report a 69-year-old patient without typical risk factors for invasive pulmonary aspergillosis (IPA), who developed IPA two weeks after onset of symptoms. | 2020-05-15 |
| 32395425 | The chest CT found a spontaneous pneumomediastinum that resorbed over 7 days with a good clinical outcome. | 2020-05-26 |
| 32395473 | Expert members of NBS extra quality assessment in National Clinical Center of Laboratory (NCCL) give a brief consensus for NBS of IMDs in the COVID-2019 epidemic, hoping that the brief consensus could be reference for NBS of IMDs in the other epidemic areas or periods all over the world. | 2020-05-15 |
| 32395474 | Clinical severity (symptoms, laboratory and chest CT findings, etc.), clinical course, and short time outcome were analyzed after hospital admission. […] There was no significant difference in clinical severity, clinical course and in-hospital mortality between Group A and Group B. […] We observed there was no obvious difference in clinical characteristics between RAS blockers and non-RAS blockers groups. […] These data suggest ACEIs/ARBs may have few effects on increasing the clinical severe conditions of COVID-19. | 2020-05-15 |
| 32395487 | The epidemic of Coronavirus Disease 2019 (COVID-19) has become a global health emergency, but the clinical characteristics of COVID-19 are not fully described. […] We aimed to describe the clinical characteristics of COVID-19 outside of Wuhan city; and to develop a multivariate model to predict the risk of prolonged length of stay in hospital (ProLOS). […] Medical records of all confirmed cases of COVID-19 were retrospectively reviewed. […] Our study described clinical characteristics of COVID-19 outside of Wuhan city and found that the illness was less severe than that in the core epidemic region. | 2020-05-15 |
| 32395542 | Symptoms, such as fever and cough caused by cancer, and the therapeutic process (including chemotherapy and surgery) should be differentiated from some COVID-19 related characteristics. […] Besides, clinical workers should not only consider the therapeutic strategy for cancer, but also emphasize COVID-19’s prevention. | 2020-05-15 |
| 32395550 | The respiratory tract is the main route of transmission of the virus, and the majority of symptoms are respiratory relative. […] After antiviral and anti-infective treatment, the symptoms recovered. | 2020-05-15 |
| 32395567 | Imaging is primarily performed in patients with a negative RT-PCR, but a high clinical suspicion of COVID-19, or, in patients with diagnosed COVID-19 who are suffering from moderate to severe symptoms. | 2020-05-16 |
| 32395672 | Recognizing the need to provide access to treatment and the anticipated toxicity of such treatment, we have developed and implemented guidelines for clinical care management with the hope of avoiding added risk to our patients. | 2020-05-15 |
| 32395673 | We highlight their clinical symptoms, imaging findings, potential confounders, and clinical workflow to triage these patients to the next level of care. | 2020-05-15 |
| 32395720 | We surveyed over 3,000 doctoral psychologists about the impact of the COVID-19 health crisis on their clinical practices. | 2020-05-15 |
| 32395788 | The purpose of our study was to report epidemiological, clinical, radiological and therapeutic features of patients with 2019-nCoV infection admitted in the pneumology department. […] Common symptoms included fever (100%), shortness of breath (70%) and cough (70%). | 2020-05-13 |
| 32395831 | These protocols were disseminated online at covidneurology.org on April 3, 2020, and have been updated continuously based on emerging literature and frontline clinical experience. | 2020-05-12 |
| 32395850 | The Australian Treatment Outcomes Profile (ATOP) is a brief clinical tool measuring recent substance use, health and wellbeing among clients attending alcohol and other drug (AOD) treatment services. | 2020-05-12 |
| 32395964 | In this article, we review the first studies into COVID-19-associated coagulopathy and give the most important do’s and don’ts for diagnostics and the daily management of coagulopathy and the prevention of complications in patients with, or with strongly-suspected, COVID-19 in Dutch clinical practice. | 2020-05-20 |
| 32395966 | Clinical characteristics and outcomes among older patients with a SARS-CoV-2 infection differ greatly from those seen in younger patients. […] Here we highlight atypical presentations of this fulminant infectious disease COVID-19, based on a clinical case and a cohort of 19 patients admitted to a geriatric ward. […] Clinical laboratory results considered typical for COVID-19 were present less often in this frail older population. […] As in other countries, morbidity and mortality is most severe among frail male patients; therefore, assessment of changes suggestive of typical acute geriatric syndromes in frail older patients with chronic diseases should lead to a careful clinical examination for a SARS-CoV-2 infection. | 2020-05-20 |
| 32396101 | Coronavirus disease 2019 (COVID-19) has emerged as a pandemic with serious clinical manifestations including death. […] The article will focus specifically on 1) wearable devices suitable for monitoring the populations at risk and those in quarantine, both for evaluating the health status of caregivers and management personnel, and for facilitating triage processes for admission to hospitals; 2) unobtrusive sensing systems for detecting the disease and for monitoring patients with relatively mild symptoms whose clinical situation could suddenly worsen in improvised hospitals; and 3) telehealth technologies for the remote monitoring and diagnosis of COVID-19 and related diseases. | 2020-05-14 |
| 32396137 | Therefore, the aim of this document, prepared by the COVID-19 taskforce of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC), is to provide a set of recommendations, adapted from official documents of international and national health agencies, on biosafety measures for routine clinical chemistry laboratories that operate at biosafety levels 1 (BSL-1; work with agents posing minimal threat to laboratory workers) and 2 (BSL-2; work with agents associated with human disease which pose moderate hazard). […] We believe that the interim measures proposed in this document for best practice will help minimazing the risk of developing COVID-19 while working in clinical laboratories. | 2020-05-12 |
| 32396143 | We aimed to consider clinical characteristics, laboratory data of COVID-19 that provided more information for the research of this novel virus. […] We performed a retrospective cohort study on the clinical symptoms and laboratory findings of a series of the 100 confirmed patients with COVID-19. | 2020-05-12 |
| 32396163 | To develop and validate a clinical score at hospital admission for predicting which patients with COVID-19 will develop critical illness based on a nationwide cohort in China. […] Epidemiological, clinical, laboratory, and imaging variables ascertained at hospital admission were screened using Least Absolute Shrinkage and Selection Operator (LASSO) and logistic regression to construct a predictive risk score (COVID-GRAM). | 2020-05-20 |
| 32396239 | Studies have demonstrated that comorbidities, especially cardiovascular and endocrine diseases, correlated with poorer clinical outcomes. […] We extracted clinical data regarding 95 patients in Jin-yin tan hospital, Wuhan, China between January 26th , 2020 and February 21st . […] Among hospitalized patients with COVID-19, RSI score greater than 13, indicative of LPRD, correlated with poorer clinical outcomes. | 2020-05-12 |
| 32396384 | Besides mounting a massive response to the viral outbreak, healthcare systems needed to consider provision of clinical services to other patients in need. […] Key determinants of robust thoracic surgery service provision included: preexisting plans for an epidemic response, aggressive early action to “flatten the curve”, ability to dedicate resources separately to COVID-19 and routine clinical services, prioritization of thoracic surgery, and the volume of COVID-19 cases in that region. | 2020-05-15 |
| 32396445 | Data on demographics, comorbidities, COVID-19 symptoms and severity, consult reason, treatment, and personal protective equipment (PPE) use were collected and analyzed. | 2020-05-15 |
| 32396491 | The coronavirus disease 2019 (COVID-19) pandemic has disrupted all aspects of clinical care, including cancer clinical trials. […] In March 2020, ASCO launched a survey of clinical programs represented on its Cancer Research Committee and Research Community Forum Steering Group and taskforces to learn about the types of changes and challenges that clinical trial programs were experiencing early in the pandemic. […] Respondents indicated that COVID-19 is leading programs to halt or prioritize screening and/or enrollment for certain clinical trials and cease research-only visits. […] Numerous challenges with conducting clinical trials were reported, including enrollment and protocol adherence difficulties with decreased patient visits, staffing constraints, and limited availability of ancillary services. […] The changes in clinical trial procedures identified by the survey could serve as strategies for other programs attempting to maintain their clinical trial portfolios during the COVID-19 pandemic. […] Additionally, many of the adaptations to trials made during the pandemic provide a long-term opportunity to improve and transform the clinical trial system. […] Specific improvements could be expanded use of more pragmatic or streamlined trial designs, fewer clinical trial-related patient visits, and minimized sponsor and CRO visits to trial programs. | 2020-05-12 |
| 32396504 | We report 3 clinical cases of patients in Italy with COVID-19 who developed abdominal viscera infarction, demonstrated by computed tomography. | 2020-05-12 |
| 32396505 | Results from all 3 assays were highly correlated during clinical specimen testing. | 2020-05-12 |
| 32396670 | Prior to testing, HCW were asked about the presence of 10 symptoms. […] Dry cough, regardless of the presence or absence of other symptoms, was the most sensitive (74%) and the least specific (32%) symptom. […] The existing testing criteria consisting of any combination of one or more of three symptoms (fever, shortness of breath, dry cough) was 93% sensitive and 9% specific (AUC = 0.63, 95% CI: 0.59 - 0.67). […] The derived testing criteria consisting of any combination of one or more of two symptoms (fever, loss of taste or smell) was 89% sensitive and 48% specific (AUC = 0.75, 95% CI: 0.71 - 0.78). […] The hybrid testing criteria consisting of any combination of one or more of four symptoms (fever, shortness of breath, dry cough, loss of taste or smell) was 98% sensitive and 8% specific (AUC = 0.77, 95% CI: 0.73 - 0.80). | 2020-05-12 |
| 32396759 | The emerging clinical reality is that methanol poisoning around the globe has claimed increasingly large numbers of deaths largely due to the press of poverty and the delay in suspecting and diagnosing methanol toxicity. | 2020-05-25 |
| 32396769 | Current approved drugs or molecules under clinical trials can be a good pool for repurposing through in-silico techniques to quickly identify promising drug candidates. | 2020-05-30 |
| 32396771 | We have also displayed the ongoing clinical trials, as well as a published study that was conducted on compassionate base. | 2020-05-30 |
| 32396877 | In this article, we summarise the physiology and virulence of SARS-CoV-2 and discuss the implications for breath testing (in both the clinical and research arena) as well as outlining methods to mitigate these risks. | 2020-05-12 |
| 32396947 | Patients monitored for hypertension as an outpatient should receive written instructions on the important signs and symptoms of disease progression and provided contact information to report the development of any concern for change in status. […] As the clinical management of gestational hypertension and preeclampsia is the same, assessment of urinary protein is unnecessary in the management once a diagnosis of a hypertensive disorder of pregnancy is made. […] Pregnant women with suspected hypertensive disorders of pregnancy and signs and symptoms associated with the severe end of the disease spectrum (e.g., headaches, visual symptoms, epigastric pain, and pulmonary edema) should have an evaluation including complete blood count, serum creatinine level, and liver transaminases (aspartate aminotransferase and alanine aminotransferase). | 2020-05-12 |
| 32396948 | Based on the incorporation of telehealth into prenatal care for high-risk patients, specific recommendations are made for the following conditions, clinical scenarios, and services: (1) hypertensive disorders of pregnancy including preeclampsia, gestational hypertension, and chronic hypertension; (2) pregestational and gestational diabetes mellitus; (3) maternal cardiovascular disease; (4) maternal neurologic conditions; (5) history of preterm birth and poor obstetrical history including prior stillbirth; (6) fetal conditions such as intrauterine growth restriction, congenital anomalies, and multiple gestations including monochorionic placentation; (7) genetic counseling; (8) mental health services; (9) obstetric anesthesia consultations; and (10) postpartum care. | 2020-05-12 |
| 32396985 | Children/young adults seem to have a less severe clinical manifestation of COVID-19 (2), but data on disease susceptibility in pediatric transplant recipients on chronic immunosuppressive therapy are limited (3, 4). | 2020-05-12 |
| 32396996 | In this review, we aim to improve our understanding on the immune response and immunopathological changes in patients linked to detoriating clinical conditions such as, cytokine storm, acute respiratory distress syndrome, autopsy findings and changes in acute phase reactants and serum biochemistry in COVID-19. | 2020-05-12 |
| 32396999 | The clinical and histopathological features and relationship to COVID-19 have not been well described. […] The objective of this case series is to describe the clinical features and determine the histopathologic findings and clinical implications of the clusters of acral perniosis cases identified in pediatric patients. […] Affected patients had mild symptoms of viral upper respiratory infection (URI) or contact with symptomatic persons 1-2 weeks preceding the rash. […] While SARS-CoV-2 polymerase chain reaction was negative, testing was performed 1-2 weeks after URI symptoms or sick contact exposure. […] We offer a clinical approach to evaluation of patients with this presentation and discuss the possibility that these skin findings represent a convalescent-phase cutaneous reaction to SARS-CoV-2 infection. | 2020-05-12 |
| 32397008 | Further research is required before these devices can be considered safe for clinical use. | 2020-05-12 |
| 32397011 | We analyzed 465 confirmed cases in Zhejiang province to determine the epidemiological, clinical, and virological characteristics of COVID-19. […] Epidemiological, demographic, clinical, laboratory, and management data from qRT-PCR confirmed COVID-19 patients from January 17, 2020, to January 31, 2020, were collected, followed by multivariate logistic regression analysis for independent predictors of severe/critical-type COVID-19 and bioinformatic analysis for features of SARS-CoV-2 from Zhejiang province. […] Fever and cough were the most common symptoms, while diarrhea/vomiting was reported in 58 (12.47%) patients. […] SARS-CoV-2 showed virological mutations and more human transmission in Zhejiang province, indicating considerable epidemiological and clinical changes. | 2020-05-19 |
| 32397174 | Typical manifestations consist of flu-like symptoms such as fever, cough, fatigue, and dyspnea. […] However, such a use should follow a multidisciplinary approach, be accompanied by close monitoring, be tailored to patient’s clinical and serological features, and be initiated at the right time to reach the best results. | 2020-05-14 |
| 32397182 | Although considerable progress has been achieved, including demonstration of safety and immunogenicity of H7N9 VLPs in the human clinical trials, the remaining challenges need to be addressed. | 2020-05-19 |
| 32397262 | Such tests can be performed on nasopharyngeal and oropharyngeal swabs for the categories of those with symptoms and those potentially exposed. | 2020-05-18 |
| 32397399 | Secondary outcomes included clinical and laboratory data. Results: There were 112 patients evaluated (82 were male and 30 were female, with a median age of 63.55 years). | 2020-05-13 |
| 32397511 | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), with a clinical outcome ranging from mild to severe, including death. […] To date, it is unclear why some patients develop severe symptoms. | 2020-05-14 |
| 32397515 | Half of these cases developed symptoms before arrival, most of the remainder developed symptoms 1-13 days (mean 4.0 days) after arrival, and 3.4% never developed symptoms. […] Three-quarters of the cases had respiratory symptoms, 44.9% had fever, 13.1% lost smell or taste, and 7.2% had diarrhoea. | 2020-05-18 |
| 32397530 | While telemedicine has been able to solve some problems in clinical ophthalmology, the lack of adequate health and legal protection for surgeons and patients may result in an excessive reduction in the volume of surgical interventions during a pandemic era and the immediately following period, thus determining inability to ensure health care to all patients. | 2020-05-13 |
| 32397643 | After molecular dynamics calculations of the stability of the binding modes of high-scoring nsp16/nsp10-drug complexes, we considered their pharmacological overlapping with functional modules of the virus-host interactome that is relevant to the viral lifecycle, and to the clinical features of COVID-19. | 2020-05-19 |
| 32397688 | The spectrum of symptoms ranges from asymptomatic infections to mild respiratory symptoms to the lethal form of COVID-19 which is associated with severe pneumonia, acute respiratory distress, and fatality. | 2020-05-19 |
| 32397896 | This study describes the pathology and clinical information on 20 placentas whose mother tested positive for the novel Coronovirus (2019-nCoV) cases. | 2020-05-14 |
| 32397906 | A broad-spectrum of antiviral agents are being currently evaluated in clinical trials, and in this review, we specifically focus on the application of Remdesivir (RVD) as a potential anti-viral compound against Middle East respiratory syndrome (MERS) -CoV, SARS-CoV and SARS-CoV-2. […] Finally, some ongoing challenges and future perspective on the application of RDV either alone or in combination with other anti-viral agents against CoVs infection were surveyed to determine the efficiency of RDV in preclinical trials. | 2020-05-30 |
| 32397911 | This review highlights the preventive measures, available clinical therapies and the potential of vaccine development against SARS-CoV-2 by taking into consideration the strong genetic similarities of the 2003 epidemic SARS-CoV. […] Recent studies are investigating the repurposing of US FDA-approved drugs as there is no available vaccine yet with many attempts under clinical evaluation. | 2020-05-22 |
| 32397915 | Increasing the understanding of PLT functions in COVID-19 will undoubtedly improve our knowledge on disease pathogenesis, clinical management, and therapeutic options, but could also lead to the development of more precise therapeutic strategies for COVID-19 patients. | 2020-05-13 |
| 32397940 | In order to provide potential lead molecules against the Mpro for clinical use, we docked a set of 65 bioactive molecules of Tea plant followed by exploration of the vast conformational space of protein-ligand complexes by long term molecular dynamics (MD) simulations (1.50 µs). | 2020-05-30 |
| 32397951 | It was also revealed that acute and chronic cardiovascular diseases (CVDs) may result in the clinical severity of COVID-19. | 2020-05-13 |
| 32398026 | The allo-priming is performed using activated, intentionally mismatched, ex vivo differentiated and expanded living Th1-like cells (AlloStim®) derived from healthy donors currently in clinical use as an experimental cancer vaccine. | 2020-05-18 |
| 32398164 | However, synthesis and full investigation from preclinical studies to phase III trials of new medications is a time-consuming procedure, and not viable in a global emergency, such as the one we are facing. […] Most drugs considered for repurposing/repositioning in the therapy of the COVID-19 outbreak are commercially available and their dosage and toxicity in humans is well known, due to years (or even decades) of clinical use. […] This can allow their fast-track evaluation in phase II-III clinical trials, or even within straightforward compassionate use. | 2020-05-14 |
| 32398268 | There is growing evidence regarding the imaging findings of COVID-19 in chest X-rays and computed tomography (CT) scans; however, their availability to clinical staff in this pandemic outbreak might be compromised. […] Clinical examination was unremarkable. […] During follow up, subpleural consolidations appeared before symptoms slightly aggravated (cough, tiredness and fever). […] We emphasise the utility and the opportunity that LUS presents in some clinical scenarios, like this COVID-19 pandemic, and how it may serve as a monitoring and therapy guide. | 2020-05-13 |
| 32398322 | Other than symptoms of the respiratory tract, many children may present with gastrointestinal symptoms. | 2020-05-13 |
| 32398343 | There is no evidence to support the use of azithromycin for the treatment of COVID-19 outside of the context of clinical trials, unless it is used to treat bacterial super-infection. […] Well-conducted clinical trials are urgently needed in this area. | 2020-05-13 |
| 32398569 | In contrast to initial reports, recent studies suggest that children are just as likely as adults to become infected with the virus but have fewer symptoms and less severe disease. […] In this review, we summarize the epidemiologic and clinical features of children infected with SARS-CoV-2 reported in pediatric case series to date. […] The most common symptoms were cough (48%; range 19%-100%), fever (42%; 11%-100%) and pharyngitis (30%; 11%-100%). […] Further symptoms were nasal congestion, rhinorrhea, tachypnoea, wheezing, diarrhea, vomiting, headache and fatigue. | 2020-05-18 |
| 32398954 | We summarized epidemiology, virological characteristics, clinical symptoms, diagnostic methods, clinical treatments, and prevention methods for COVID-19 to present a reference for the future wave of probable CoV outbreaks. | 2020-05-15 |
| 32399192 | Clinical protection is still suboptimal for all of these reasons, and vaccine uptake remains too low in most countries. | 2020-05-19 |
| 32399213 | Clinical data of the patient were collected from medical records. | 2020-05-16 |
| 32399375 | Results While an overall positive response toward this mode of neurosurgical education was expected, interesting insights were gained from the short-answer section, demonstrating a direct influence on clinical practice through online conference participation. | 2020-05-16 |
| 32399393 | We report the first case of 2019-nCoV infection in a patient with Ankylosing Spondylitisthe (AS), who was a biological agent (anti-TNFα) user in Wenzhou, China, and describe the clinical course and management of the case. | 2020-05-31 |
| 32399449 | The most common symptoms are fever and cough, which can progress to pneumonia, acute respiratory distress syndrome (ARDS) and/or end-organ failure. […] Deep vein thrombosis and pulmonary embolism can occur in patients with COVID-19 pneumonia.Low-molecular-weight heparin prophylaxis does not decrease the risk of venous thromboembolism (VTE) in COVID-19 pneumonia.In the presence of clinical signs and/or suspicion of VTE, compression ultrasound and echocardiography should be always performed, irrespective of disease stage. | 2020-05-16 |
| 32399450 | During his hospitalization in an isolation ward, he had no respiratory distress or fever but developed symptoms consistent with anxiety and insomnia. […] The COVID-19 pandemic requires social distancing, quarantine and isolation, which may precipitate new psychiatric symptoms in people without mental illness or aggravate existing conditions.Mental health service providers, including psychiatrists, clinical psychologists and social workers, should be available in every facility taking care of COVID-19 patients.Health workers treating patients during the COVID-19 pandemic should be aware of symptoms of depression, anxiety, insomnia and/or distress developing in their patients and colleagues. | 2020-05-16 |
| 32399453 | We report the clinical, laboratory and radiological findings of a patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). | 2020-05-16 |
| 32399455 | The rapid clinical and biochemical improvement following TCZ administration suggests that treatment with immunotherapy can be life-saving in selected patients with COVID-19-induced CRS. […] Cytokine release syndrome may cause sudden and potentially life-threatening clinical deterioration in COVID-19 pneumonia, particularly in younger patients.Immunosuppressive therapy may provide important additional therapeutic benefit in these patients.Tocilizumab, a specific IL-6 inhibitor, led to dramatic clinical improvement in a young patient with severe COVID-19-associated cytokine release syndrome. | 2020-05-16 |
| 32399457 | We describe the case of a 59-year-old man who presented with headache, hypertension and a single episode of fever with no other symptoms. | 2020-05-16 |
| 32399507 | We estimated the reproduction number, R, during the early transmission phase in Lima from the daily series of imported and autochthonous cases by the date of symptoms onset as of March 30th, 2020. […] Prior to the implementation of the social distancing measures in Lima, the local incidence curve by the date of symptoms onset displays near exponential growth dynamics with the mean scaling of growth parameter, p, estimated at 0.9 (95%CI: 0.9,1.0) and the reproduction number at 2.3 (95% CI: 2.0, 2.5). | 2020-05-29 |
| 32399655 | Therefore, new therapeutic strategies are needed to improve clinical outcomes, particularly in patients with severe disease. […] Adverse reactions to CAP-1002, clinical status on the World Health Organization (WHO) ordinal scale, and changes in pro-inflammatory biomarkers and leukocyte counts were analyzed. | 2020-05-14 |
| 32399710 | To investigate the clinical and chest CT characteristics of COVID-19 pneumonia and explore the radiological differences between COVID-19 and influenza. […] The clinical data and the chest CT findings were recorded. […] The most common symptoms of COVID-19 were fever (74%) and cough (63%), and 102 patients (83%) had Wuhan contact. | 2020-05-16 |
| 32399719 | Case analysis indicated that the nervous system can be invaded by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and that 36.4% of COVID-19 patients had neurological symptoms. […] Here, we discussed the symptoms and evidence of nervous system involvement (directly and indirectly) caused by SARS-CoV-2 infection and possible mechanisms. […] CNS symptoms could be a potential indicator of poor prognosis; therefore, the prevention and treatment of CNS symptoms are also crucial for the recovery of COVID-19 patients. | 2020-05-29 |
| 32399908 | The availability of COVID-19 clinical guidelines and patient information sheets on national plastic surgery society websites is sparse. | 2020-05-16 |
| 32399942 | Clinical and surgical practices which are standard in normal times may not be standard or safe during the COVID-19 crisis. | 2020-05-16 |
| 32399950 | During Italian severe acute respiratory syndrome coronavirus-2 outbreak, a woman presented with a rapidly progressive flaccid paralysis with unilateral facial neuropathy after a few days of mild respiratory symptoms. […] Despite immunoglobulin infusions and intensive supportive care, her clinical picture worsened simultaneously both from the respiratory and neurological point of view, as if reflecting different aspects of the same systemic inflammatory response. | 2020-05-16 |
| 32399995 | There were no significant differences in time delays or severity of clinical symptoms for patients treated by IVT or MT, nor in the distribution of final diagnosis among stroke alerts and stroke unit admissions. | 2020-05-13 |
| 32400017 | At the same time, in the near future, clinical trials in COVID-19 patients will produce an enormous quantity of clinical and translational data on the control of inflammation, and complement/microthrombosis activation. | 2020-05-13 |
| 32400044 | This case emphasizes the risks of discharge location in the COVID-19 era as well as the importance of clinical suspicion, early isolation practices for those presumed positive, and repeat testing, given the marginal sensitivity of available COVID-19 RT-PCR. | 2020-05-13 |
| 32400074 | In this paper we report anamnestic data, clinical features and therapeutic management of two lung transplant recipients with confirmed COVID-19 pneumonia. […] Both patients were in good clinical conditions prior to the infection and were on immunosuppression with calcineurin inhibitors (CNI), mycophenolate mofetil and corticosteroids. […] He was discharged with a satisfactory pulmonary function and a complete resolution of radiological and clinical findings. […] The second patient required mechanical ventilation, had a progressive deterioration of his clinical conditions and had a fatal outcome. | 2020-05-13 |
| 32400087 | The isolation of SARS-CoV-2 from non-lung clinical specimens, the detection of SARS-CoV-2 in autopsy specimens, previous experience with the related coronaviruses SARS-CoV and MERS-CoV, and the vast experience with other common RNA respiratory viruses are all addressed. | 2020-05-13 |
| 32400366 | Diagnosing IV can be challenging, because its clinical features are subject to great variation, ranging from mild cases with slight xerosis to severe cases with marked scaling and formation of fissures. | 2020-05-18 |
| 32400371 | This case report describes a physician in the early 30ies with subjective anosmia and ageusia as the major presenting symptoms of COVID-19. […] Two weeks after normalisation of the mild sino-nasal symptoms, the patient was tested positive for SARS-CoV-2, and anosmia was verified with Sniffin’ Sticks tests. […] Olfactory and gustatory loss may be underestimated symptoms of COVID-19. | 2020-05-18 |
| 32400380 | This review aims to elucidate potential mechanisms, which make HCQ treatment interesting in the fight against SARS-CoV-2 infection, as well as the current evidence for clinical use of HCQ to treat COVID-19. | 2020-05-18 |
| 32400911 | Based on lessons learned from prior studies and clinical delivery of CPT via telehealth, recommendations are made with regard to overall strategies for adapting CPT to a telehealth format, including how to conduct routine assessments and ensure treatment fidelity. | 2020-05-13 |
| 32400924 | Therefore, we have brought together the relevant clinical leads from SIOP Europe, COG, and SIOP-PODC (Pediatric Oncology in Developing Countries) to focus on the six most curable cancers that are part of the WHO Global Initiative in Childhood Cancer. | 2020-05-29 |
| 32400931 | He was a permanent resident in Wuhan, China, and began having symptoms on January 29 (day 1 of illness). | 2020-05-13 |
| 32400965 | Faced with this novel coronavirus, scientists have been trying to use drugs that have not been validated by rigorous clinical trials, such as lopinavir/ritonavir (LPV/r) and hydroxychloroquine (HCQ). | 2020-05-13 |
| 32401064 | Accurate and rapid diagnostic tools are essential for early recognition and treatment of infectious diseases, allowing timely implementation of infection control, improved clinical care and other public health measures to stop the spread of the disease. | 2020-05-26 |
| 32401079 | The main areas of concern were: campus-based teaching and learning; clinical teaching; selection and assessment, and educator needs. | 2020-05-13 |
| 32401210 | We conducted data mining on Sina Weibo and extracted the data of 485 patients who presented with clinical symptoms and imaging descriptions of suspected or laboratory-confirmed cases of COVID-19. […] Most patients had fever symptoms, and ground-glass opacities were noted in chest computed tomography. | 2020-05-28 |
| 32401211 | Searches for symptoms of diarrhea, fever, shortness of breath, cough, nasal obstruction, and rhinorrhea all had a negative lag greater than 1 week compared to new daily cases, while searches for anosmia and dysgeusia peaked worldwide and in China with positive lags of 5 days and 6 weeks, respectively, corresponding with widespread media coverage of these symptoms in COVID-19. […] Although certain online search trends for this disease were influenced by media coverage, many search terms reflected clinical manifestations of the disease and showed strong correlations with real-world cases and deaths. | 2020-05-27 |
| 32401215 | A telephone-based survey was administered in Spain to 93 participants in the TV-AssistDem clinical trial from March 25 to April 6, 2020. […] Health status was found to be optimal in 89/93 respondents (96%), with no COVID-19 symptoms. | 2020-05-27 |
| 32401359 | The clinical manifestations and clinical outcomes of these patients are not clear. […] We described the clinical characteristics, clinical manifestations, treatments and clinical outcomes of both patients. […] The experience of these two cases suggested that COVID-19 patients with HIV infection could still have satisfactory clinical outcomes following proper medical care. | 2020-05-13 |
| 32401360 | During the COVID-19 pandemic: In patients with cancer with fever and/or respiratory symptoms, consider causes in addition to COVID-19, including other infections and therapy-related pneumonitis. […] Australasian Leukaemia and Lymphoma Group; Australasian Lung Cancer Trials Group; Australian and New Zealand Children’s Haematology/Oncology Group; Australia and New Zealand Society of Palliative Medicine; Australasian Society for Infectious Diseases; Bone Marrow Transplantation Society of Australia and New Zealand; Cancer Council Australia; Cancer Nurses Society of Australia; Cancer Society of New Zealand; Clinical Oncology Society of Australia; Haematology Society of Australia and New Zealand; National Centre for Infections in Cancer; New Zealand Cancer Control Agency; New Zealand Society for Oncology; and Palliative Care Australia. | 2020-05-31 |
| 32401361 | This study aims to observe the clinical characteristics of recovered patients from Coronavirus Disease 2019 (COVID 19) with positive in RT-PCR or serum antibody. […] The profile, clinical symptoms, laboratory outcomes and radiologic assessments were extracted on 11 patients, who tested positive for COVID-19 with RT-PCR or serum antibody after discharged and was admitted to Hubei No. […] The main symptoms were cough (54.5%), fever (27.3%) and feeble (27.3%) in the second hospitalization. […] Compared with the first hospitalization, there were significant decreases in gastrointestinal symptoms (5 vs. […] Additionally, 6 patients’ chest CT exhibited notable improvements in acute exudative lesions CONCLUSION: There could be the positive results for RT-PCR analysis or serum IgM-IgG in discharged patients, even with mild clinical symptoms, however, their laboratory outcomes and chest CT images would not indicate the on-going development in those patients. | 2020-05-13 |
| 32401550 | While important and effective innovations are appearing almost daily, there are also some worrying trends towards hobbyists attempting manufacture of complex medical devices with little understanding of the clinical or scientific rationale behind their design. | 2020-05-13 |
| 32401630 | Its clinical manifestations may have similarities to other septic, thoracic, or gastrointestinal post-surgical complications. […] We sought to evaluate the frequency of COVID-19 in a cohort of patients who had recently had operations who were undergoing imaging for acute symptoms and the role of chest computed tomography (CT) in this setting. Patients and Methods: We included all patients who had chest CT for acute symptoms in the 15 days after a surgical procedure between March 1 and 31, 2020. Results: Of 46 patients with acute post-operative symptoms requiring chest imaging, eight (17%) were ultimately diagnosed with COVID-19. […] In centers with a high prevalence of COVID-19, chest acquisition should be included in CT scans done for acute post-operative symptoms. | 2020-05-13 |
| 32401670 | Corticosteroids, through their suppressive effects on type 2 inflammation, are thus likely to restore impaired anti-viral immunity in asthma and, in contrast to non-asthmatic subjects, have beneficial clinical effects in the context of SARS-CoV-2 infection. | 2020-05-13 |
| 32401673 | We argue for inhibition of the TRPV4 calcium-permeable ion channel as a strategy to address this issue, based on the rationale that TRPV4 inhibition is protective in various preclinical models of lung edema, and that TRPV4 hyperactivation potently damages the alveolo-capillary barrier, with lethal outcome. […] A clinical trial using a selective TRPV4 inhibitor demonstrated a benign safety profile in healthy volunteers and in patients suffering from cardiogenic lung edema. […] We argue for expeditious clinical testing of this inhibitor in Covid-19 patients with respiratory malfunction and at risk for lung edema. | 2020-05-13 |
| 32401715 | Early triple antiviral therapy was safe and superior to lopinavir-ritonavir alone in alleviating symptoms and shortening the duration of viral shedding and hospital stay in patients with mild to moderate COVID-19. […] Future clinical study of a double antiviral therapy with interferon beta-1b as a backbone is warranted. | 2020-05-31 |
| 32401844 | Its symptoms include fever, cough, and headache, but the main one is shortness of breath. | 2020-05-13 |
| 32401931 | In this sense, dental offices, both in the public and private sectors, are high-risk settings of cross infection among patients, dentists and health professionals in the clinical environment (including hospital’s intensive dental care facilities). […] Dentists should consider that a substantial number of individuals (including children) who do not show any signs and symptoms of COVID-19 may be infected and can disseminate the virus. | 2020-05-19 |
| 32401989 | Most of the infected patients present with mild symptoms, not requiring hospitalization. | 2020-05-18 |
| 32402061 | However, little is known about their clinical performance. […] However, diagnostic sensitivity was poor in both assays during the first 14 days of symptoms. | 2020-05-29 |
| 32402090 | Liver impairment has been frequently reported as a common manifestation, although its clinical significance is still unclear, particularly in patients with underlying chronic liver disease (CLD). | 2020-05-13 |
| 32402104 | Clinical symptoms of the COVID-19 includes cough (67.8%), fever (43.8%), fatigue (38.1%), production of sputum (33.7%), and shortness of breath (18.7%). […] Gastrointestinal symptoms of COVID-19 include nausea or vomiting (5.0%), as well as diarrhea (3.8%) 1 . | 2020-05-13 |
| 32402130 | Remdesivir has emerged as a promising treatment for SARS-Co-V-2 infection yet published clinical pharmacology and drug interaction studies are limited. | 2020-05-13 |
| 32402433 | Moreover, COVID-19 and EBV co-infections do not seem to aggravate the clinical outcome. | 2020-05-16 |
| 32402477 | One of the most important strategies to reduce and mitigate the advance of the epidemic are social distance measures; this is where telemedicine can help, and provide support to the healthcare systems, especially in the areas of public health, prevention and clinical practices, just as it is doing in others sectors. | 2020-05-31 |
| 32402532 | In this context, the allocation of resources or the prioritization of treatment become crucial elements, and it is important to have an ethical reference framework to be able to make the necessary clinical decisions. | 2020-05-16 |
| 32402764 | This has led to significant changes in the way geriatric oncologists provide care to older patients, including the implementation of novel methods for clinical visits, interruptions or delays in procedures, and modification of therapeutic strategies, both in the curative and palliative settings. | 2020-05-29 |
| 32402766 | In a first clinical trial, CQ was effective in inhibiting exacerbation of pneumonia, improving lung imaging findings, promotion of virus-negative conversion, and shortening the disease. | 2020-05-26 |
| 32403008 | To assess the assay’s clinical performance, we tested a large panel of previously studied specimens: 192 human respiratory specimens from pneumonia patients, 5 clinical specimens from COVID-19 patients, 81 poultry oral secretion specimens, 109 pig slurry specimens, and 31 aerosol samples from a live bird market. | 2020-05-29 |
| 32403010 | Days since onset of symptoms was collected from their medical records. […] This study shows accurate and equivalent performance of the five serological antibody assays (ELISA, CLIA and three lateral flow tests) in detecting SARS-CoV-2 antibodies 14 days after the onset of COVID-19 symptoms. […] This is compatible with their application in specific clinical contexts and in determining epidemiological strategies for the COVID-19 pandemic. | 2020-05-31 |
| 32403153 | After the first PCR turned in negative another PCR-analysis for SARS-CoV-2 of a deep oral swab-sample was performed since the clinical, laboratory and radiological findings were typical for COVID-19. […] Due to clinical recovery antiviral therapy was not performed after confirming the diagnosis. […] The patient was discharged 17 days after onset of first symptoms without any requirements for further isolation. […] This casuistic describes a case of COVID-19 associated pneumonia presenting with typical clinical features, laboratory and radiological findings. […] Analysis of deeper airway samples (sputum, bronchoalveolar lavage, tracheal secretions) or stool for SARS-CoV-2 should be performed in cases of evident clinical suspicion of COVID-19 and negative PCR results from deep oral swabs. | 2020-05-13 |
| 32403168 | Case-based teaching conferences, such as morning report, offer trainees a forum to refine their clinical reasoning skills. […] To meet this need, the Clinical Problem Solvers developed and implemented a multi-institutional, online model for morning report called, “virtual morning report (VMR).” | 2020-05-13 |
| 32403176 | In the meantime, clinical activities of medical students (MS) were on hold, and teaching had to be restructured to online formats. | 2020-05-22 |
| 32403182 | Governments are investing in public health, clinical and research efforts to avoid the spread of the SARS-CoV-2 virus, reduce the number of deaths and prevent the collapse of health care systems. | 2020-05-13 |
| 32403217 | The symptoms most commonly reported by patients affected by coronavirus disease (COVID-19) include cough, fever, and shortness of breath. […] Herein, we report a systematic and comprehensive evaluation of both clinical and preclinical evidence supporting the hypothesis that the endothelium is a key target organ in COVID-19, providing a mechanistic rationale behind its systemic manifestations. | 2020-05-22 |
| 32403255 | The novel coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection has been predominantly linked to respiratory distress syndrome, but gastrointestinal symptoms and hepatic injury have also been reported. […] We aimed to systematically review data on the prevalence of hepatic impairments and their clinical course in SARS and MERS Coronaviridae infections. […] More studies to elucidate the mechanism and importance of liver injury on the clinical course and prognosis in patients with novel SARS-CoV-2 infection are warranted. | 2020-05-14 |
| 32403895 | Healthcare professionals from all specialties are facing this situation and designing guidelines and recommendations that are contributing to the literature that is crucial for disease management at the current time. | 2020-05-14 |
| 32403911 | After aerosol infection, most people experience mild respiratory infection with cold symptoms such as cough and fever, and healing within two weeks. […] This review article considers epidemiological aspects of novel corona virus infection and presents both the clinical as well the possible economic effects of the pandemic on gynaecology, obstetrics and reproductive medicine in Germany in the past, present and future. […] In addition, useful preventive measures for daily clinical work and the previously known scientific findings dealing with the impact of corona virus on pregnancy and birth are discussed. | 2020-05-14 |
| 32404011 | The current study aimed to explore the clinical characteristics of COVID-19 complicated by hypertension. […] Compared with the non-hypertensive group, the lymphocyte count was significantly lower in the hypertensive group (average value, 0.96 × 109/L vs 1.26 × 109/L), and analysis of clinical outcomes showed that the crude mortality rate was higher in the hypertensive group [7/36 (19.4%) vs 2/74 (2.7%)]. | 2020-05-20 |
| 32404126 | This study aims to assess the effectiveness of delivering Solution Focused Brief Therapy (SFBT) through telecommunication with a group of adolescents who present anxiety symptoms during the COVID-19 outbreak. […] We hypothesize that participants who are randomly assigned to receive 2-4 sessions of Solution Focused Brief Therapy would have better clinical outcomes than participants who are in the waitlist group. […] This study employs a randomized delayed crossover open label controlled trial in adolescents who are presenting anxiety symptoms during the COVID-19 outbreak. | 2020-05-15 |
| 32404258 | Here we present the clinical case of a Spanish woman with bipolar disorder that included coronavirus infection in her delusional themes even faster than the real infection reached mainland Spain. | 2020-05-16 |
| 32404302 | Various clinical scenarios, as well as management algorithms for patients with a diagnosed or suspected COVID-19 infection, presenting with ST- and non-ST-segment elevation ACS are described. | 2020-05-14 |
| 32404376 | The clinical sequelae vary from mild, self-limiting upper respiratory infection symptoms to severe respiratory distress, acute cardiopulmonary arrest and death. […] In this paper, we review existing literature and the clinical course of SARS-CoV-2 in relation to the reported symptoms of hyposmia, hypogeusia and dysgeusia. | 2020-05-18 |
| 32404436 | Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA are frequently observed in COVID-19 patients. | 2020-05-18 |
| 32404451 | What should I tell parents worried about their children contracting the coronavirus (SARS-CoV-2) causing COVID-19, and what symptoms should I look for to determine if there is a need to test for the virus? […] Only 5% of those tested and found to have COVID-19 have been younger than 19 years, possibly owing to limited testing, as the symptoms in children are usually mild. […] Symptoms in children include fever, dry cough, rhinorrhea, sore throat, and fatigue, and in 10% diarrhea or vomiting. | 2020-05-15 |
| 32404473 | Clinical investigations facilitated development of accurate case definition and guidance for laboratories on the optimum specimens and procedures for diagnoses. | 2020-05-14 |
| 32404477 | A competition assay indicates their different epitopes on the RBD, making them a potential virus-targeting MAb-pair to avoid immune escape in future clinical applications. | 2020-05-22 |
| 32404498 | We should adapt CME sessions to keep trainees up to date with core clinical competencies as they will continue to manage both COVID-19 and non-COVID-19 cases and this pandemic may last until year’s end. | 2020-05-29 |
| 32404512 | In the absence of proven antiviral agents or an effective vaccine, substances with immunomodulatory activity may be able to inhibit inflammatory and Th1 cytokines and/or yield an anti-inflammatory and/or Th2 immune response to counteract COVID-19 symptoms and severity. […] This report briefly describes the following four unconventional but commercially accessible immunomodulatory agents that can be employed in clinical trials to evaluate their effectiveness at alleviating disease symptoms and severity: low-dose oral interferon alpha, microdose DNA, low-dose thimerosal, and phytocannabinoids. | 2020-05-20 |
| 32404514 | A number of drugs that have been approved for other diseases are being tested for the treatment of COVID-19 patients, but there is an absence of data from appropriately designed clinical trials showing that these drugs, either alone or in combination, will prove effective. | 2020-05-20 |
| 32404711 | We reach out to our ACNM (American College of Nuclear Medicine) international members from Wuhan, China and Singapore, who have participated in dealing with COVID-19 for the last 2 months, to learn from their lessons and experiences, so to provide advice to all ACNM members for their clinical practice and management strategies in responding to COVID-19. | 2020-05-14 |
| 32404718 | We performed a review of the existing literature regarding COVID-19 and prior viral outbreaks to help guide clinical practice in terms of how to safely perform medically necessary orthopaedic procedures during the pandemic for both asymptomatic patients and high-risk (e.g., COVID-19-positive) patients. | 2020-05-14 |
| 32404780 | The patient showed a prolonged manifestation of symptoms and a protracted diagnosis period of COVID-19. | 2020-05-14 |
| 32404786 | To describe the characteristics of clinical manifestations of children with 2019 novel coronavirus (2019-nCoV) infection in Chongqing. […] Clinical data and epidemiological history of these patients were retrospectively collected and analyzed. […] These patients could be categorized into different clinical types, including 8 (32%) asymptomatic, 4 (16%) very mild cases and 13 (52%) common cases. […] The most common symptoms were cough (13 cases, 52%) and fever (6 cases, 24%). […] The duration time of clinical symptoms was 13.0 (8.0-25.0) days. […] The morbidity of 2019-nCoV infection in children is lower than in adults and the clinical manifestations and inflammatory biomarkers in children are nonspecific and milder than that in adults. | 2020-05-14 |
| 32404896 | To describe the clinical and analytical features of a coronavirus disease 2019 (Covid-19) infected cohort with SCI to enable accurate diagnosis and to outline prevention measures. […] Clinical, analytical, and radiographic findings were registered. […] Our patients with SCI and Covid-19 infection exhibited fewer symptoms than the general population. […] Furthermore, they presented similar or greater clinical severity. […] The clinical evolution was not as pronounced as had been expected. […] This study recommends close supervision of the SCI population to detect early compatible signs and symptoms of Covid-19 infection. | 2020-05-19 |
| 32404899 | The aim of this study was to assess the nutritional risks among older patients with COVID-19 and their associated clinical outcomes using four nutritional risk screening (NRS) tools: Nutrition Risk Screening 2002 (NRS 2002), Malnutrition Universal Screening Tool (MUST), Mini Nutrition Assessment Shortcut (MNA-sf), and Nutrition Risk Index (NRI). […] We retrospectively analyzed the data of patients with COVID-19 older than 65 years who were treated in our hospital from January 28, 2020 to March 5, 2020, and explored the relationship between nutritional risk and clinical outcomes. | 2020-05-16 |
| 32405028 | Development of gastrointestinal symptoms in some patients with COVID-19 and detection of viral RNA in fecal specimens suggest that SARS-CoV-2 might cause enteric, in addition to respiratory, infection3,4. | 2020-05-14 |
| 32405071 | The impact of discontinuing ACEI and ARBs in patients with COVID-19 remains uncertain.DESIGNBRACE CORONA is a pragmatic, multicenter, randomized, phase IV, clinical trial that aims to enroll around 500 participants at 32 sites in Brazil. […] BRACE CORONA will evaluate whether the strategy of continued ACEI/ARB therapy compared with temporary discontinuation of these drugs impacts clinical outcomes among patients with COVID-19. | 2020-05-16 |
| 32405073 | While we continue to see patients, this is the time to engage outside clinical encounters by participating in lobbying and other advocacy efforts to preserve essential services, protecting the health, life, and welfare of our patients during COVID-19. | 2020-05-14 |
| 32405081 | The present analytical paper on the role of point-of-care lung ultrasound in this pandemic examines its diagnostic accuracy, clinical utility, and physical practicality in the intensive care unit. | 2020-05-14 |
| 32405093 | We review different biomarkers to evaluate if they are able to predict clinical outcomes and correlate with the severity of COVID-19 disease. | 2020-05-23 |
| 32405102 | SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. […] The role of human genetics in determining clinical response to the virus remains unclear. | 2020-05-14 |
| 32405111 | This study explored the prevalence of post-traumatic stress disorder (PTSD) and depression in a sample of home-quarantined college students to identify the psychological distress risk factors. : The PTSD and depressive symptoms in the 2485 participants from 6 universities were investigated using online survey versions of the PTSD Checklist Civilian Version and the 9-question Patient Health Questionnaires (PHQ-9), and data on sleep durations, exposure, home-quarantine time and socio-demographic variables were also collected. : The PTSD and depression prevalence were found to be 2.7% and 9.0%. | 2020-05-16 |
| 32405115 | Individuals with substance user disorders (SUD) are at risk population for contamination due to multiple factors - attributable to their clinical, psychological and psychosocial conditions. | 2020-05-22 |
| 32405150 | The 18.7% of the sample revealed depressive, 21.6% anxiety and 15.8% PTSD symptoms. […] However, female gender, previous diagnoses of mental health problems or neurological disorders, having symptoms associated with the virus, or those with a close relative infected were associated with greater symptomatology in all three variables. | 2020-05-22 |
| 32405160 | Patients receiving tocilizumab showed significantly greater survival rate as compared to control patients (hazard ratio for death, 0.035; 95% confidence interval [CI], 0.004 to 0.347; p = 0.004), adjusting for baseline clinical characteristics. […] Tocilizumab results to have a positive impact if used early during Covid-19 pneumonia with severe respiratory syndrome in terms of increased survival and favorable clinical course. | 2020-05-16 |
| 32405162 | We report here a case of the asymptomatic patient and present clinical characteristics of 455 contacts, which aims to study the infectivity of asymptomatic carriers. 455 contacts who were exposed to the asymptomatic COVID-19 virus carrier became the subjects of our research. […] We extracted their epidemiological information, clinical records, auxiliary examination results and therapeutic schedules. […] During the quarantine, seven patients plus one family member appeared new respiratory symptoms, where fever was the most common one. | 2020-05-26 |
| 32405164 | The first report of the unusual manifestation of pneumonia-like symptoms in Wuhan City, China was made on 31 December 2019. […] One such potential clinical protocol is proposed as a hypothesis. | 2020-05-16 |
| 32405183 | The worldwide pandemic of COVID-19, caused by the virus SARS-CoV,-2 has continued to progress, and increasing information is becoming available about the incidence of digestive symptoms as well as abnormal liver-associated enzymes in patients who are infected. […] The most common digestive symptoms are anorexia, nausea, vomiting, and diarrhea. […] Currently there is no firm evidence to suggest that severity of digestive symptoms corresponds to severity of COVID-19 clinical course, however, more severe alterations in liver enzymes may correlate with worse clinical course. | 2020-05-16 |
| 32405229 | Hypertension and CVD, after the adjustment for other clinical and demographic parameters, primarily age, did not remain independent predictors of the lethal outcome in COVID-19 patients. | 2020-05-23 |
| 32405236 | The respiratory disease that it caused, COVID-19 (stands for coronavirus disease in 2019), has similar clinical symptoms with other two CoV diseases, severe acute respiratory syndrome and Middle East respiratory syndrome (SARS and MERS), of which causative viruses are SARS-CoV and MERS-CoV, respectively. […] These three CoVs resulting diseases also share many clinical symptoms with other respiratory diseases caused by influenza A viruses (IAVs). […] This is a discussion and comparison of the virus structures, transmission characteristics, clinical symptoms, diagnosis, pathological changes, treatment and prevention of the two kinds of viruses, CoVs and IAVs. | 2020-05-23 |
| 32405245 | We investigated the clinical course of individuals with 2019 novel coronavirus disease (COVID-19) who were transferred from the Diamond Princess cruise ship to 12 local hospitals. […] The conditions and clinical courses of patients with pneumonia were compared with those of patients without pneumonia. […] Among 70 patients (median age: 67 years) analyzed, the major symptoms were fever (64.3%), cough (54.3%), and general fatigue (24.3%). | 2020-05-16 |
| 32405253 | In addition, 220 clinical and laboratory observations/records were also collected. […] Clinical indicators were associated with severe/critical symptoms were identified and a model for severe/critical symptom prediction was developed. […] Totally, 36 clinical indicators significantly associated with severe/critical symptom were identified. […] The clinical indicators are mainly thyroxine, immune related cells and products. […] Cox multivariate regression and survival analyses revealed that the model significantly discriminated the severe/critical cases and used the information of the selected clinical indicators. | 2020-05-22 |
| 32405270 | Given that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA has demonstrated stability, we posited that phosphate-buffered saline (PBS) may be a viable transport medium, as an alternative to VTM, for clinical real-time quantitative PCR (qPCR) testing. […] The intra-individual reliability and interindividual reliability of SARS-CoV-2 qPCR were assessed in clinical endotracheal secretion samples transported in VTM or PBS to evaluate the stability of the qPCR signal for three viral targets (N gene, ORF1ab, and S gene) when samples were stored in these media at room temperature for up to 18 hours. | 2020-05-30 |
| 32405288 | Patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection mainly present with upper and lower respiratory tract symptoms, with complications related to cytokine storm syndrome and acute respiratory distress syndrome. | 2020-05-31 |
| 32405411 | A number of drugs, both new and old, are currently in clinical trials and being used on an experimental basis in clinical practice. | 2020-05-31 |
| 32405421 | Twenty-nine studies were identified as potential sources of evidence of the clinical safety of favipiravir. | 2020-05-16 |
| 32405422 | A review of nitazoxanide clinical research was conducted using EMBASE and MEDLINE databases, supplemented by ClinicalTrials.gov. […] If efficacy against SARS-CoV-2 is demonstrated in clinical studies, nitazoxanide may represent a safe and affordable treatment in the ongoing pandemic. | 2020-05-16 |
| 32405423 | Several promising drugs have been identified and are in various stages of clinical trials globally. | 2020-05-16 |
| 32405452 | Collected data included the current MS DMT and patient-reported disability level, history of recent sick contact, recent fever, respiratory symptoms, diagnosis with COVID-19, and the disposition after the diagnosis. […] We calculated the proportion of COVID-19-suspect patients and compared their demographics, clinical characteristics, and DMT categories with the rest of survey-responders, using univariable and multivariable models. | 2020-05-27 |
| 32405454 | The patient referred to treatment clinic for COVID-19 in Imam Reza hospital of Tabriz (Iran) after having flu-like symptoms. | 2020-05-30 |
| 32405509 | We discuss the current knowledge gaps driven by questions around the quality and consistency of clinical trial results, patient selection, diagnostic methodologies, use of suppressive antibiotic therapy, and methods for adverse event reporting. […] We provide specific recommendations for future trial designs of FMT to provide improved quality of the clinical evidence to better inform treatment guidelines. | 2020-05-14 |
| 32405603 | The prevalence and prognosis of digestive system involvement, including gastrointestinal symptoms and liver injury, in patients with COVID-19 remains largely unknown. […] We included studies that reported the epidemiological and clinical features of COVID-19 and the prevalence of gastrointestinal findings in infected patients, and excluded preprints, duplicate publications, reviews, editorials, single case reports, studies pertaining to other coronavirus-related illnesses, and small case series (<10 cases). […] Extracted data included author; date; study design; country; patient demographics; number of participants in severe and non-severe disease groups; prevalence of clinical gastrointestinal symptoms such as vomiting, nausea, diarrhoea, loss of appetite, abdominal pain, and belching; and digestive system comorbidities including liver disease and gastrointestinal diseases. […] We analysed findings from 35 studies, including 6686 patients with COVID-19, that met inclusion criteria. 29 studies (n=6064) reported gastrointestinal symptoms in patients with COVID-19 at diagnosis, and the pooled prevalence of digestive system comorbidities was 4% (95% CI 2-5; range 0-15; I2=74%). […] The pooled prevalence of digestive symptoms was 15% (10-21; range: 2-57; I2=96%) with nausea or vomiting, diarrhoea, and loss of appetite being the three most common symptoms. […] Subgroup analysis showed patients with severe COVID-19 had higher rates of gastrointestinal symptoms (odds ratio [OR] 1·60 [95% CI 1·09-2·36]; p=0·0020; I2=44%) and liver injury (2·20 [1·60-3·02]; p<0·00001; I2=36%) compared with those with non-severe disease. […] Paediatric patients with COVID-19 had a similar prevalence of gastrointestinal symptoms to those of adult patients. […] 10% (95% CI 4-19; range 3-23; I2=97%) of patients presented with gastrointestinal symptoms alone without respiratory features. […] Our study showed that digestive symptoms and liver injury are not uncommon in patients with COVID-19. | 2020-05-16 |
| 32405641 | Various clinical scenarios, as well as management algorithms for patients with a diagnosed or suspected COVID-19 infection, presenting with ST- and non-ST-segment elevation ACS are described. | 2020-05-20 |
| 32405780 | The effectiveness and safety of drug therapy need to be confirmed by more clinical studies. | 2020-05-19 |
| 32405872 | In any cases, COVID symptoms including fever and increased temperature should be constantly monitored until the day of surgery. | 2020-05-16 |
| 32405955 | We identify and review some of the short- and long-term consequences of this global pandemic for the community of ataxia patients and their families and for the clinical and academic neurologists/ataxiologists caring for these patients. | 2020-05-16 |
| 32405974 | This paper provides a clinical reference and a new strategy for the optimal treatment of COVID-19 worldwide. | 2020-05-15 |
| 32406001 | In this case report, we describe the clinical features of 5 rheumatic immune disease patients with the concomitant presence of COVID-19. […] Fever (80%), cough (80%), dyspnea (40%), and fatigue (20%) were the most common presenting symptoms. | 2020-05-16 |
| 32406140 | This review examines the evidence for this hypothesis, and its implications for clinical practice. […] Necessary precautions to prevent person-to-person transmission should be employed in clinical practice throughout the pandemic, and patients should be reminded to maintain good hygiene practices. | 2020-05-14 |
| 32406181 | He had an excellent clinical recovery within four days and was able to be discharged home. […] His respiratory symptoms resolved but the diarrhea persisted during a 4 week follow-up period. […] This report provides a brief perspective on the short-term COVID-19 clinical course in an immunosuppressed child. | 2020-05-14 |
| 32406305 | Adequate infection control measures are necessary during day-to-day clinical work. | 2020-05-29 |
| 32406317 | It is noteworthy that Viomycin showed higher -CDocker energy as compared to the drugs currently under clinical trial for SARS-CoV-2 treatment viz. Ritonavir and Lopinavir. | 2020-05-25 |
| 32406369 | Significant clinical presentations of COVID-19 include respiratory symptoms and pneumonia. […] Infection of such extrapulmonary organs may serve as a reservoir for SARS-CoV-2, representing a potential source of viral shedding after the cessation of respiratory symptoms in recovered patients or in asymptomatic individuals. | 2020-05-14 |
| 32406374 | The clinical manifestations of COVID-19 include fever, dry cough, fatigue, sputum production, shortness of breath, sore throat, and headache. | 2020-05-14 |
| 32406420 | To discuss the high resolution computed tomography (HRCT) manifestations of coronavirus disease 2019 (COVID-19) patients among different clinical types on initial and follow-up CT. […] The main CT features and semi-quantitative score which represent disease severity among different clinical types were evaluated. […] CT scanning can accurately assess the severity of COVID-19, and help to monitor disease transformation during follow-up among different clinical conditions. | 2020-05-16 |
| 32406522 | Currently affecting more than 3,000,000 individuals worldwide, COVID-19 is most commonly associated with symptoms caused by the acute respiratory distress syndrome (ARDS). […] The gastrointestinal symptoms, like for example diarrhoea, vomiting, nausea, or abdominal pain are frequent in patients with COVID-19. […] Moreover, alimentary tract symptoms may precede the respiratory presentation of SARS-CoV-2 infection. […] Here, we aim to provide an update on the gastrointestinal involvement of COVID-19 presenting the symptoms that can be encountered in infected patients. | 2020-05-14 |
| 32406536 | In this Perspective, we provide evidence, where available, regarding the general care of patients with osteoporosis in the COVID-19 era and provide clinical recommendations based primarily on expert opinion when data are absent. […] It is hoped that these recommendations can be used to safely guide care for patients with osteoporosis until a return to routine clinical care standards is available. | 2020-05-26 |
| 32406551 | To compare the number of patients attending the Urology ED of Centro Hospitalar Universitário do Porto (CHUP), as well as their demographic characteristics, the reasons for admission, the clinical severity under the Manchester triage system (MTS), and the need for emergency surgery or hospitalization, during the pandemic and the equivalent period in 2019. […] No significant differences were noted between different clinical severity groups under the MTS. | 2020-05-14 |
| 32406594 | Clinical characteristics and outcomes (as of April 4, 2020) were compared among control (group 1), secondary hyperglycaemia (group 2: no diabetes history, FPG levels ≥7.0 mmol/L once and HbA1c values <6.5%) and diabetic (group 3) patients. | 2020-05-14 |
| 32406606 | More eye swabs should be collected from COVID-19 patients, especially from those immunocompromised, those with eye symptoms and those had a history of ocular diseases. | 2020-05-14 |
| 32406637 | Here the clinical data are summarized of the first 236 patients that have been admitted to hospitals in Uden, Breda and Tilburg which were all at the centre of the initial outbreak in the Netherlands. […] This commentary focusses on the clinical characteristics of the patients that are currently being treated on the Dutch clinical corona units, their medical management and the first clinical outcomes. | 2020-05-20 |
| 32406638 | Patients with fever with no apparent cause and patients with recently developed respiratory symptoms, whether or not in combination with fever, were routinely given a PCR test, blood tests (lymphocyte count and LDH levels) and a chest CT scan. […] In case of patients who have been referred to an emergency department for suspected COVID-19, a good COVID-19 risk assessment can be made on the basis of clinical signs, laboratory abnormalities and low-dose CT scans. | 2020-05-20 |
| 32406852 | The vast majority were aware of the main symptoms, mode of transmission, high risk groups, and aware of how to use personal protective equipment. | 2020-05-14 |
| 32406927 | We rated the certainty of evidence using the GRADE approach for the following outcomes: all-cause mortality at hospital discharge, improvement of clinical symptoms (7, 15, and 30 days after transfusion), grade 3 and 4 adverse events, and serious adverse events. […] Improvement of clinical symptoms (assessed by respiratory support) Six studies, including 28 participants, reported the level of respiratory support required; most participants required respiratory support at baseline. […] All studies reported improvement in clinical symptoms in at least some participants. […] We do not know whether convalescent plasma improves clinical symptoms (very low-certainty evidence). | 2020-05-19 |
| 32406952 | Most of the literature show that the elevated liver enzymes in COVID-19 are of little clinical significance. | 2020-05-25 |
| 32407051 | The endpoints are the improvement of clinical symptoms and laboratory parameters of these patients. […] The optimal dose and time point, as well as the clinical benefit of hyper- immune/convalescent plasma therapy, needs further investigation in larger well-controlled trials. | 2020-05-14 |
| 32407142 | Consumers, clinicians, and policymakers need balanced information that is free of commercial influence to make decisions about the best ways to prevent the spread and manage the symptoms and clinical consequences of COVID-19. | 2020-05-14 |
| 32407151 | These include the need to embrace telemedicine, advice on surgical prioritization, planning of clinical area flow plans, advice on pre-/peri- and postoperative care as well as recommendations on training for residents and well-being for surgeons. | 2020-05-14 |
| 32407255 | Clinical and laboratory variables were collected. […] Multivariable logistic regression was utilized to evaluate the relationship between clinical parameters, CXR scores, and patient outcomes. | 2020-05-14 |
| 32407284 | Limited data are available on the clinical presentation and outcomes of coronavirus disease (COVID-19) patients in the United States hospitalized under normal-caseload or nonsurge conditions. | 2020-05-20 |
| 32407289 | This viewpoint suggested different strategies and measures for case detection and contact tracing, clinical management of cases, public health system functioning, and civil society organizations contribution. | 2020-05-14 |
| 32407303 | Another 25 persons had compatible symptoms. | 2020-05-15 |
| 32407411 | Among the infected Chinese healthcare workers whose symptoms onset appeared during the same ten-day period, the percentage of those in severe conditions decreased significantly from 19.7% (Jan 11-20) to 14.4% (Jan 21-31) to 8.7% (Feb 1-11). […] The clinical outcomes of infected Chinese healthcare workers may represent a more accurate estimation of the severity of COVID-19 for those who have access to quality healthcare. | 2020-05-19 |
| 32407459 | We conducted a systematic review and meta-analysis of all published studies up to March 15, 2020 which reported COVID-19 clinical features and/or treatment outcomes. 45 studies reporting 4203 patients were included. | 2020-05-29 |
| 32407464 | We also aim to draw parallels between the clinical/chemosensory symptomology reported in association to past coronavirus pandemics (such as SARS and MERS) and the novel COVID-19. | 2020-05-29 |
| 32407467 | Little is known about the clinical outcomes of HIV patients infected with SARS-CoV-2. | 2020-05-29 |
| 32407491 | ACE2 binding compounds and 7 antiviral drugs were closely embedded in which two of them have been under clinical trial for COVID-19. iBioProVis and its carefully filtered dataset are available at https://ibpv.kansil.org/ for public use. | 2020-05-14 |
| 32407539 | Yet, generating clinical evidence of efficacy and safety of these candidate treatments may be frustrated by the absence of comprehensive trial coordination mechanisms. […] We here discuss actions that all stakeholders in the clinical trial ecosystem need to take to ensure that the window of opportunity during this pandemic will not shut, both for patients in need of treatment and for researchers to conduct decision-relevant clinical trials. | 2020-05-14 |
| 32407561 | Recent news stories have explicitly stated that patients with symptoms of COVID-19 were “turned away” from emergency departments. | 2020-05-14 |
| 32407564 | Many clinical manifestations of the virus are described, and new symptoms are emerging, only few cases of patients with skin manifestation were described since the pandemic was announced by the WHO on March. […] Common clinical features of COVID-19 reported include fever, cough, myalgia, fatigue, headache, shortness of breath and diarrhea. | 2020-05-14 |
| 32407609 | Patient 2 had COVID-19 pneumonia, and fluctuating mental status that raised the suspicion of subclinical SE. | 2020-05-14 |
| 32407719 | To describe the clinical profiles and risk factors for critical illness in hospitalized children and adolescents with COVID-19. […] Demographic and clinical data were collected. 67 children tested positive for COVID-19; 21 (31.3%) were managed as outpatients. | 2020-05-30 |
| 32407799 | Whilst there has been a growing literature base describing the early clinical course of COVID-19 and on aspects of critical care related to treating these patients, there has been a dearth of evidence on how this pandemic will affect surgical practice. | 2020-05-16 |
| 32407808 | Multiple gastrointestinal (GI) symptoms including diarrhea, nausea/vomiting, and abdominal pain, as well liver enzyme abnormalities have been variably reported in patients with COVID-19. […] The AGA) Institute Clinical Guideline Committee and Clinical Practice Updates Committee performed a systematic review and meta-analysis of international data on GI and liver manifestations of COVID-19. […] Pooled prevalence estimates of GI symptoms was diarrhea 7.7% (95% CI 7.2-8.2), nausea/vomiting 7.8% (95% CI 7.1-8.5), abdominal pain 2.7% (95% CI 2.0-3.4). […] Isolated GI symptoms were rarely reported. […] We also summarized of the Gl and liver adverse effects of the most commonly utilized medications for COVID19 CONCLUSIONS: GI symptoms are associated with COVID-19 in less than 10% of patients. […] Further studies are needed with standardized GI symptoms questionnaires and LFT checks on admission to better quantify and qualify the association of these symptoms with COVID-19. | 2020-05-16 |
| 32407893 | The clinical features that were significantly related to infection were chill, shortness of breath, chest pain and nausea. | 2020-05-17 |
| 32407937 | To investigate the clinical features of COVID-19 cases in Suzhou China. | 2020-05-29 |
| 32407959 | The primary outcome was the change in clinical status based on a 7-category ordinal scale (1 = not hospitalised, resuming normal daily activities; 7 = deceased). […] Our data suggest that remdesivir can benefit patients with SARS-CoV-2 pneumonia hospitalised outside ICU where clinical outcome was better and adverse events are less frequently observed. | 2020-05-31 |
| 32408043 | However, there exists limited statistical method to estimate a comprehensive risk for a case in which a patient has several characteristics and symptoms concurrently. […] We applied Boolean Monte Carlo method (BMCM) to the Novel Corona Virus 2019 Dataset to determine interrelation of patient’s characteristics and symptoms. | 2020-05-29 |
| 32408047 | Research and clinical observations suggest that during times of pandemic many people exhibit stress- or anxiety-related responses that include fear of becoming infected, fear of coming into contact with possibly contaminated objects or surfaces, fear of foreigners who might be carrying infection (i.e., disease-related xenophobia), fear of the socio-economic consequences of the pandemic, compulsive checking and reassurance-seeking regarding possible pandemic-related threats, and traumatic stress symptoms about the pandemic (e.g., nightmares, intrusive thoughts). […] A stable 5-factor solution was identified, corresponding to scales assessing COVID-related stress and anxiety symptoms: (1) Danger and contamination fears, (2) fears about economic consequences, (3) xenophobia, (4) compulsive checking and reassurance seeking, and (5) traumatic stress symptoms about COVID-19. | 2020-05-29 |
| 32408070 | The antimalarial drug chloroquine (CQ) and its metabolite hydroxychloroquine (HCQ) are currently being tested in several clinical studies as potential candidates to limit SARS-CoV-2-mediated morbidity and mortality. […] Therefore, CQ/HCQ in combination with zinc should be considered as additional study arm for COVID-19 clinical trials. | 2020-05-26 |
| 32408119 | The objectives were to determine the epidemiological, clinical, laboratory, and radiological characteristics of COVID-19 patients. […] The most common symptoms were: fever (n = 8; 53.3%), cough (n = 7; 46.7%), shortness of breath (n = 3; 20.0%), fatigue (n = 3; 20.0%), and taste and smell disorders (n = 4; 26.7%). | 2020-05-27 |
| 32408156 | These results will provide a helpful reference for diagnosis and clinical treatment of COVID-19 patients. | 2020-05-29 |
| 32408336 | We established a human cell culture model for infection with SARS-CoV-2 clinical isolate. | 2020-05-14 |
| 32408528 | Public understanding, including knowledge about signs and symptoms, mode of transmission, and hygiene of COVID-19, is vital for designing effective control strategies during a public health crisis. […] Questions were focused on the prevention, transmission, clinical features, and control of COVID-19. | 2020-05-16 |
| 32408699 | However, essential oil components may act synergistically, essential oils may potentiate other antiviral agents, or they may provide some relief of COVID-19 symptoms. | 2020-05-18 |
| 32408730 | This special article introduces clinical practice guidelines to prevent secondary transmission of COVID-19 within hemodialysis facilities, which were developed to protect patients, healthcare workers, and caregivers from this highly transmissible virus. | 2020-05-15 |
| 32408776 | The results of the systematic review of the existing literature are presented in the following nine sections: Symptoms of the COVID-19 in pregnancy, Pregnancy management, Delivery Management, Mode of delivery, Recommendations for health care provider in delivery, Neonatal outcomes, Neonatal care, Vertical Transmission, Breastfeeding. | 2020-05-15 |
| 32408845 | Results - Transmission of infectious viruses from patient to surgeon during surgery is possible, but does not appear to be a considerable problem in clinical practice. | 2020-05-15 |
| 32408911 | We reviewed the current evidence on the transmission dynamics and on pathogenic and clinical features of COVID-19 to critically identify any gaps in the current infection prevention and control (IPC) guidelines. […] We extracted information related to COVID-19 transmission dynamics, clinical presentations, and exposures that may facilitate transmission. | 2020-05-29 |
| 32409114 | Older adults and patients with comorbidities and immunosuppressive conditions may experience severe signs and symptoms that can lead to death. […] This case series assesses the clinical course, imaging features, and outcomes for 12 patients with COVID-19 and a history of kidney transplantation. […] Patients were evaluated for symptoms, laboratory data, imaging findings, and outcomes from February 2020 to April 2020. […] Fever, cough, and dyspnea were the most common clinical symptoms, noted in 75% (nine/12), 75% (nine/12), and 41.7% (five/12) of the patients, respectively. | 2020-05-18 |
| 32409150 | Two outcomes were sudden cardiac arrest/ventricular arrhythmias (SCA/VA) and cardiac symptoms. […] The adjusted incidence of cardiac symptoms among azithromycin and amoxicillin users was 276 vs 254 per 10,000 person-years with an adjusted HR of 1.10 (95%CI, 0.62-1.95). | 2020-05-18 |
| 32409163 | None of the nursing/medical staff presented signs or symptoms of COVID-19 within 15 days after the procedure. | 2020-05-18 |
| 32409210 | The patients had all commonly reported symptoms of Covid-19. […] In particular, elder patients with prothrombotic risk factors should also be considered for the signs of cerebrovascular events in addition to infectious symptoms. | 2020-05-18 |
| 32409215 | The most common reported symptoms to include headache and dizziness followed by encephalopathy and delirium. | 2020-05-16 |
| 32409230 | Based on the data available from the scientific literature and ongoing clinical trials, we have focused on therapeutic strategies. | 2020-05-16 |
| 32409298 | Second, many of the considerations on how we should adapt clinical practice in neuro-oncology in view of COVID-19 that are now dominating discussions at local tumour boards, as well as on the institutional level and within societies of neuro-oncology, are not novel but have been valid before and only now have become a priority. | 2020-05-16 |
| 32409328 | We searched registries of clinical trials, websites of governmental and other relevant organisations, reference lists of the included papers and relevant systematic reviews, and Epistemonikos for relevant systematic reviews. | 2020-05-19 |
| 32409432 | This novel, team-based approach to caring for patients with COVID-19 incorporates a self-monitoring app for patient engagement, monitors symptoms for early intervention, and promotes a holistic view of care. | 2020-05-15 |
| 32409433 | Several antivirals are being investigated for symptomatic COVID-19 but no definitive data support their clinical use. […] A randomized controlled trial of lopinavir/ritonavir demonstrated no apparent clinical or virologic benefit and drug-drug interactions and side effects further limit its utility. […] Antivirals with evidence of clinical activity must be studied as treatment and prophylaxis for those at high risk for severe COVID-19. | 2020-05-16 |
| 32409434 | At this time, there is no clinical evidence to suggest that treatment with RAS inhibitors should be discontinued in stable patients with COVID-19. […] In hospitalized patients with severe COVID-19, decisions about these medications should be based on clinical condition, including hemodynamic status and renal function. | 2020-05-28 |
| 32409437 | Rapid, sweeping changes for successful management are based on creating an educational platform to introduce and then further cement these concepts through a unified approach to clinical care. | 2020-05-15 |
| 32409438 | A targeted combination of psychopharmacology (targeting acute anxiety and panic symptoms) and psychotherapy (relaxation techniques, breathing exercises, and encouragement) is recommended. | 2020-05-28 |
| 32409439 | The pandemic has created major ethical and practical questions about patient selection and nonapproved use vs use in the context of a randomized clinical trial. | 2020-05-15 |
| 32409440 | Cardiac imaging has different utility in different clinical scenarios, and the importance of minimizing healthcare worker exposure should be considered. | 2020-05-15 |
| 32409441 | Results of clinical trials and data from the Global Rheumatology Alliance registry are eagerly awaited to gain further insight into the impact of this novel infection on our vulnerable patient population. | 2020-05-15 |
| 32409442 | Some of these cutaneous manifestations arise before the signs and symptoms more commonly associated with COVID-19, suggesting that they could be presenting signs of COVID-19. utaneous manifestations are well known to occur in the setting of viral illnesses, and occasionally these manifestations have diagnostic or prognostic value. | 2020-05-16 |
| 32409498 | Here, we describe the clinical characteristics of and outcomes in patients with diabetes in whom COVID-19 has been confirmed or clinically diagnosed (with typical features on lung imaging and symptoms), and their association with glucose-lowering or blood pressure-lowering medications. […] In this retrospective study involving 904 patients with COVID-19 (136 with diabetes, mostly type 2 diabetes), clinical and laboratory characteristics were collected and compared between the group with diabetes and the group without diabetes, and between groups taking different medications. […] Clinical outcomes of those who use an ACE inhibitor (ACEI) or angiotensin II type-I receptor blocker (ARB) were comparable with those of patients who do not use ACEI/ARB among patients with diabetes and hypertension who have COVID-19. | 2020-05-15 |
| 32409502 | Obese patients tended to have symptoms of cough (P = 0.03) and fever (P = 0.06) compared with patients who were not obese. | 2020-05-15 |
| 32409504 | Demographic, clinical, and laboratory data were abstracted. | 2020-05-15 |
| 32409625 | We conclude by considering how a justifiable process of reallocating professionals to high-risk clinical roles should be configured once those who are ‘fit for reallocation’ have been identified. | 2020-05-28 |
| 32409826 | To assess the case fatality risk (CFR) of COVID-19 in mainland China, stratified by region and clinical category, and estimate key time-to-event intervals. | 2020-05-29 |
| 32409832 | This Viewpoint summarizes the strong scientific arguments supporting the use of alisporivir, a non-immunosuppressive analogue of cyclosporine A with potent cyclophilin inhibition properties that has reached Phase 3 clinical development, for the treatment of COVID-19. […] They include the strong cyclophilin dependency of the lifecycle of many coronaviruses, including SARS-CoV and MERS-CoV, and preclinical data showing strong antiviral and cytoprotective properties of alisporivir in various models of coronavirus infection, including SARS-CoV-2. […] Alisporivir should be tested without delay on both virological and clinical endpoints in patients with or at-risk of severe forms of SARS-CoV-2 infection. | 2020-05-29 |
| 32410141 | To analyze the expression profiles and clinical significances for this gene in humans, RNA-seq data representing 27 different tissues were analyzed using NCBI; total RNA was extracted from different tissues of mouse and semi-quantitative reverse transcriptional-polymerase chain reaction (Q-RT-PCR) was carried out. […] Taken together, this study may not only provide potential clues for further medical pathogenesis of COVID-19 and male fertility, but also indicate the clinical significance of the role of the ACE2 gene in cancer. | 2020-05-18 |
| 32410196 | Defining manageable, evidence-based protocols for testing, surgical/procedural risk mitigation and clinical flow management/contamination management will be paramount for the safety of non-urgent surgical procedures. […] Articles and referenced literature describing possible procedural impact factors leading to exacerbation of the clinical evolution of COVID-19-positive patients were identified to perform risk stratification for elective surgery. […] Based on these impact factors, considerations for patient selection, choice of procedural complexity, duration of procedure, type of anesthesia, etc., are discussed in this article and translated into algorithms for surgical/anesthesia risk management and clinical management. […] We propose a clinical algorithm to enhance patient safety in elective surgery in the context of COVID-19 and to minimize cross-contamination between healthcare workers and patients. […] New evidence-based guidelines regarding surgical risk stratification, testing, and clinical flow management/contamination management are proposed. | 2020-05-18 |
| 32410206 | Background Clinical characteristics of patients with the coronavirus disease 2019 (COVID-19) may present differently within and outside the epicenter of Wuhan, China. […] More clinical investigations are needed. […] Objective The study was aimed to describe the clinical characteristics, laboratory parameters, and therapeutic methods of COVID-19 patients in Hunan, China. […] The following data were obtained from electronic medical records: demographics, medical history, exposure history, underlying comorbidities, symptoms, signs, laboratory findings, computer tomography scans, and treatment measures. […] Main outcome measure Epidemiological, clinical, laboratory, and radiological characteristics and treatments. […] The median time from the first symptoms to hospital admission was seven days. […] The most common symptoms at the onset of illness were fever (74.5%), cough (56.9%), and fatigue (43.1%) among patients in the common-type group. […] Conclusion As of February 10, 2020, the symptoms of COVID-19 patients in Hunan province were relatively mild comparing to patients in Wuhan, the epicenter. | 2020-05-25 |
| 32410234 | Intravenous tocilizumab, an antirheumatic drug, seems to be promising in counteracting cytokine storm caused by SARS-CoV-2 infection with associated clinical improvements. […] We report herein a case series of patients with COVID-19 pneumonia who were treated with tocilizumab administrated, for the first time, subcutaneously with good clinical and radiological outcomes. | 2020-05-15 |
| 32410245 | In our study, we did a retrospective review of medical records from COVID-19 patients admitted to one ward of Tongji Hospital of Hua Zhong University of Science and Technology from 10 February to 13 April 2020. […] On the second admission, they had no symptoms and their chest CT was almost normal. | 2020-05-15 |
| 32410266 | If the activation of memory B cells can be selectively inhibited in high-risk patients at an early stage of COVID-19 to reduce the production of cross-reactive antibodies against the virus, we speculate that ADE can be circumvented and severe symptoms can be prevented. […] The mammalian target of rapamycin (mTOR) inhibitors satisfy such needs and it is recommended to conduct clinical trials for mTOR inhibitors in preventing the severity of COVID-19. | 2020-05-23 |
| 32410285 | To explore epidemiological characteristics and risk factors of COVID-19 in Chongqing and establish early warning system that provides a feasible protocol for clinical assessment of COVID-19. […] Prediction model has a high sensitivity and is easy to use, which provides a strong basis for the early clinical evaluation on the severity of COVID-19. | 2020-05-15 |
| 32410319 | Without active screening, little will be known about the clinical and epidemiological manifestations which could negatively impact public health efforts. | 2020-05-15 |
| 32410333 | The most common symptoms reported include dry cough, fever and fatigue with ground-glass opacification bilaterally in the lungs on imaging and lymphopenia on haematological analysis. […] Current evidence shows an incubation period of up to 14 days post exposure to the virus, and on average most patients first display symptoms on day five after initial exposure. | 2020-05-15 |
| 32410347 | In the context of Covid-19, key issues include providing support to clinical trials in low- and middle-income countries, without taking needed resources away from other critical clinical and public health needs; designing recruitment strategies likely to generate sufficient enrollment from groups that have been disproportionately burdened by the virus, such as African Americans; supporting studies designed to improve outcomes in high-risk environments, such as nursing homes and group homes for the developmentally disabled; and ensuring that the medical products resulting from research are made available throughout the world at an affordable price. […] If clinical trials are not designed with equity considerations consciously in mind, the response to the pandemic may further exacerbate disparities in health status between population groups. | 2020-05-15 |
| 32410386 | Physicians administered a survey-based questionnaire to SARS-CoV-2 positive patients with the aim of assessing symptoms, focusing on OD and GD. | 2020-05-15 |
| 32410412 | To identify the initial chest computed tomography (CT) findings and clinical characteristics associated with the course of coronavirus disease 2019 (COVID-19) pneumonia. […] Baseline CT scans and clinical and laboratory data of 72 patients admitted with COVID-19 pneumonia (39 men, 46.2 ± 15.9 years) were retrospectively analyzed. […] Multivariable Cox proportional hazard regression was used to explore the association between initial CT, clinical or laboratory findings, and discharge with recovery, whereby hazard ratio (HR) values < 1 indicated a lower rate of discharge at four weeks and longer time until discharge. | 2020-05-20 |
| 32410413 | To identify predictors of pulmonary fibrosis development by combining follow-up thin-section CT findings and clinical features in patients discharged after treatment for COVID-19. […] Clinical data and CT imaging features of all the patients in different stages were collected and analyzed for comparison. […] Fibrosis was more likely to develop in patients with severe clinical conditions, especially in patients with high inflammatory indicators. | 2020-05-20 |
| 32410714 | The clinical information in caring of critically ill patients with COVID-19 needs to be shared timely, especially under the situations that there is still a largely ongoing spread of COVID-19 in many countries. […] The demographic information, clinical characteristics, vital signs, complications, laboratory values, and clinical managements of the patients were studied. […] The duration from the date of ICU admission to the study date was 11 (5-17) days, and the duration from onset of symptoms to the study date was 31 (24-36) days. […] Chinese Clinical Trial Registry, ChiCTR2000030164. | 2020-05-18 |
| 32410765 | The COVID-19 pandemic has given rise to the need for changes in clinical practice, with new strategies to enable integrated care for patients with headache and neuralgia. | 2020-05-18 |
| 32410788 | We present a case of facial diplegia after 10 days of SARS-CoV-2 confirmed infection symptoms in a 61 year old patient without prior clinically relevant background. […] There are few known cases of Guillain-Barré Syndrome (GBS) related to SARS-CoV-2 infection; we propose this case as a rare variant of GBS in COVID-19 infection context, due to Its chronology, clinical manifestations and cerebrospinal fluid (CSF) findings. | 2020-05-18 |
| 32410808 | The observations at our tertiary care corroborate anecdotal reports that the number of new stroke diagnoses is falling, which seems related to a smaller proportion of patients seeking healthcare services for milder symptoms. | 2020-05-18 |
| 32410823 | •Waiting for atleast a period of 2 weeks would a prudent solution to rule out coexistence of COVID 19 infection in low risk cases without any symptoms. | 2020-05-18 |
| 32411034 | It is extremely important to understand the prevalence and influencing factors of anxiety and depression symptoms in first-line anti-epidemic medical staff and their coping styles for these negative emotions. […] A linear regression model was used to determine the influencing factors for anxiety or depression symptoms. […] The prevalence rates of anxiety and depression symptoms among doctors was 11.4% and 45.6%, respectively. […] History of depression or anxiety (T=-2.644, p= 0.010, 95%CI: -10.514~-1.481) was shown to be a risk factor for anxiety symptoms in doctors, while being male (T=2.970, p=0.004, 95%CI: 2.667~13.521) was a protective factor for depression. […] The prevalence rate of anxiety and depression symptoms among nurses was 27.9% and 43.0%, respectively. […] History of depression or anxiety was a common risk factor for anxiety symptoms (T=-3.635, p=0.000, 95%CI: -16.360~-4.789) and depression symptoms (T=-2.835, p=0.005, 95%CI:-18.238~-3.254) in nurses. […] The first-line anti-epidemic medical staff have high anxiety and depression symptoms and adopting positive coping styles will help to improve their negative emotions. | 2020-05-18 |
| 32411271 | " Demographic and clinical data was collected, including sex, age, marital status, employment, annual household income, region, current smoking status, current alcohol consumption, number of chronic physical conditions, number of chronic psychiatric conditions, any physical symptom experienced during self-isolation, and number of days of self-isolation. | 2020-05-18 |
| 32411310 | This study aimed to clarify the epidemiology and clinical characteristics of COVID-19 outside of Hubei province, China, and to optimize screening strategies for COVID-19 in attempts to contain spread of the virus. […] The epidemiology and clinical characteristic of these cases were investigated according to outcome in attempts to optimize screening strategies for COVID-19. | 2020-05-16 |
| 32411313 | These data suggest that administration of Anakinra may be beneficial for treating severe COVID-19 patients with sHLH as determined by the HScore and support the need for larger clinical studies to validate this concept. | 2020-05-28 |
| 32411359 | The clinical symptoms include multiple motor and one or more phonic (vocal) tics. […] In addition, several symptoms of GTS may mimic COVID-19, such as a dry cough and sniffing (phonic tics), while other symptoms such as spitting, inappropriate touching of others and “non-obscene socially inappropriate symptoms” can potentially get patients with GTS into trouble with the law. | 2020-05-21 |
| 32411396 | Nevertheless, new or ongoing clinical trials, not related to the disease itself, remain important for the development of new therapies, and require interactions among patients, clinicians and research personnel, which is challenging, given isolation measures. | 2020-05-16 |
| 32411552 | Anecdotal experiences have shown that imaging characteristics are crucial to diagnosis as radiological evidence of disease appears prior to clinical manifestations and tends to evolve over time, which can be useful in predicting the stage of the disease. | 2020-05-18 |
| 32411566 | Dihydropyridine calcium channel blockers (CCB) are typically used agents in the clinical management of hypertension. […] The electronic medical records for all patients that tested positive for SARS-CoV-2 that were at or above the age of 65 and that expired or survived to discharge from a community hospital in Brooklyn, NY, between the start of the public health crisis due to the viral disease up until April 13, 2020, were included. […] Further clinical studies are warranted. | 2020-05-18 |
| 32411619 | Although clinical presentation may be similar among different viruses, associated symptoms may range from a mild cold to a severe respiratory illness, and thus require a fast and reliable diagnosis. | 2020-05-19 |
| 32411751 | Notably, COVID-19 must become the research hotspot of coronavirus research, and clinical research on COVID-19 may be the key to defeating this epidemic. | 2020-05-16 |
| 32411770 | However, the clinical characteristics of discharged patients remain little known. […] Here, we attempt to describe the clinical characteristics and treatment experiences of discharged cases from Taizhou, China. | 2020-05-18 |
| 32411943 | Demographic and clinical variables were retrospectively collected, including co-morbidities and risk factors for TB and COVID-19 mortality. | 2020-05-15 |
| 32412088 | Since the outbreak, various reports detail its symptoms and outcomes, primarily focusing on respiratory complications. […] Less common symptoms include seizure, stroke and isolated cases of Guillain-Barre syndrome. […] Further research is now warranted to precisely determine the relationship between those patients developing neurological sequelae, their clinical state and any subsequent morbidity and mortality. | 2020-05-16 |
| 32412101 | However, other manifestations such as headache, abdominal pain, diarrhea, loss of taste and smell were added to the clinical spectrum, during the course of the COVID-19 pandemic. […] Headache was reported in 11%-34% of the hospitalized COVID-19 patients, but clinical features of these headaches were totally missing in available publications. | 2020-05-27 |
| 32412125 | The androgen sensitivity model explains why males are more likely to develop severe symptoms while children are ostensibly resistant to infection. […] In addition to theoretical epidemiological and molecular mechanisms, there are reports of high rates of androgenetic alopecia of from hospitalized COVID-19 patients due to severe symptoms. | 2020-05-15 |
| 32412156 | Patients with cardiovascular disease and, namely, heart failure are more susceptible to coronavirus disease 2019 (COVID-19) and have a more severe clinical course once infected. | 2020-05-16 |
| 32412159 | We performed a multicenter nationwide observational study within the Swiss Transplant Cohort Study (STCS) to describe the epidemiology, clinical presentation, treatment and outcomes of the first microbiologically documented SARS-CoV-2 infection among SOT recipients. […] The most common presenting symptoms were fever (76%), dry cough (57%), nausea (33%) and diarrhea (33%). […] These data suggest that clinical manifestations of SARS-CoV-2 infection in middle-aged SOT recipients appear to be similar to the general population without an apparent higher rate of complications. | 2020-05-15 |
| 32412303 | Since its origin in China in December 2019, there is compelling evidence that novel SARS-CoV-2 is a highly transmissible virus, and it is associated to a broad clinical spectrum going from subclinical presentation to severe respiratory distress and multi-organ failure. | 2020-05-15 |
| 32412509 | For others such as lopinavir/ritonavir, neither significant virological nor clinical benefit has been shown. | 2020-05-26 |
| 32412510 | Main manifestations of the disease include a febrile syndrome accompanied by respiratory symptoms; however, cases of systemic involvement are increasingly being reported, including cardiac and central nervous system compromise. | 2020-05-15 |
| 32412512 | In Mexico, social distancing is being applied, but studies are still required on the dynamics of the epidemic, person-to-person transmission, incidence of subclinical infections, and patient survival. | 2020-05-15 |
| 32412515 | Except for pregnant women, the management of critically ill patients with COVID-19 during the pandemic includes the standard procedures that are used for any patient that requires to be attended to at the intensive care unit, as well as limited administration of crystalloid solutions, orotracheal intubation, invasive mechanical ventilation in the event of patient clinical deterioration, and muscle relaxants continuous infusion only if necessary. | 2020-05-15 |
| 32412538 | Historically, first coronavirus had surfaced in 1965 with symptoms of common cold. | 2020-05-16 |
| 32412679 | Despite many neurologic complications associated with SARS-CoV-2 infection, it is still unclear whether these symptoms results from direct neural injury or due to some other reason. […] Currently, it appears that most of the neurological symptoms of COVID-19 are nonspecific and secondary to the systemic illness. | 2020-05-27 |
| 32412693 | The present work highlights the need to estimate the individual patient risk of infection, which depends on both epidemiological considerations and individual clinical characteristics. […] This work also provides useful suggestions on the modality of patient triage, the conduct of clinical trials, the management of an oncologic team, and the approach to patients’ and health workers’ psychological distress. | 2020-05-26 |
| 32412790 | This review aimed to assess these reports and found chest CT to have a clinical utility that is limited, particularly for patients who show no symptoms and patients who are screened early in disease progression. CONCLUSION. CT has limited sensitivity for COVID-19 and a lower specificity than RT-PCR testing, and it carries a risk of exposing providers to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] Chest CT should be considered a supplemental diagnostic tool, particularly for patients who show symptoms. | 2020-05-15 |
| 32412891 | Patients with COVID-19 disease present with a wide array of symptoms, ranging from mild flu-like complaints to life threatening pulmonary and cardiac complications. […] At present, there have been no conclusive series of reproducible randomised clinical trials demonstrating the efficacy of any one drug or therapy for COVID-19. | 2020-05-16 |
| 32412913 | While “Live” patient contact is an irreplaceable tenet of clinical teaching, these extraordinary times demand exceptional measures. […] Since the medical educators have been pushed inevitably to rely on technology-based learning, they should not only embrace it but also develop and evaluate its sustainability and application in preclinical and clinical setting. | 2020-05-15 |
| 32412914 | Telemedicine is the delivery of health care services using information or communication technology. | 2020-05-15 |
| 32412918 | An incubation period of 0 to 14 days has been reported, with acute to chronic symptoms being cough, nasal congestion, high fever, dyspnea, pneumonia, invasive lesions in both lungs, respiratory failure, and even death, including in pediatric cases. […] Several countries have started clinical trials to evaluate the safety and effectiveness of some drugs, but the ability to vaccinate people with existing or new molecules will require time. | 2020-05-15 |
| 32412931 | The rapid transition away from in-person examination, dosing and group therapy in an era of social isolation calls for adjustments to clinical practice, including emphasizing patient-provider communication, favoring new inductees on buprenorphine and leveraging technology to optimize safety of medication treatment. | 2020-05-20 |
| 32413158 | Many studies have analyzed the clinical picture of COVID-19, but they are focused on respiratory symptoms and headache is generically treated. […] More than 41,000 COVID-19 patients have been included in clinical studies and headache was present in 8%-12% of them. […] As a headache expert and based on my own personal clinical case, headaches related to COVID-19 can be classified in the 2 phases of the disease. […] All of them are headaches specified in the ICHD3, except 1 that occurs from the 7th day after the clinical onset. | 2020-05-16 |
| 32413201 | The aim of this study was to investigate exposure to SARS-CoV-2, symptoms and antibody responses in a large sample of health care workers following a COVID-19 outbreak. […] A COVID-19 outbreak among staff members of a major German children’s and women’s hospital was followed by massive RT-PCR SARS-CoV-2 tests and provided the opportunity to study symptoms, chains of infection and SARS-CoV-2 specific antibody responses (IgG and IgA) by ELISA. […] Study participants were classified as COVID-19 cases, and persons with close, moderate or no exposure to SARS-CoV-2 in the clinical setting, respectively. […] While most study participants experienced many symptoms indicative for SARS-CoV-2 infection, anosmia and coughing were remarkably more frequent in COVID-19 cases. […] Approximately 80% of COVID-19 cases developed some specific antibody response (IgA and IgG) approximately 3 weeks after onset of symptoms. | 2020-05-15 |
| 32413554 | Moreover, the rapid onset of societal disruption and evolving regulatory restrictions may not have allowed for systematic planning of how clinical and research work may continue throughout the pandemic or be restarted as restrictions are abated. […] To facilitate the re-establishment of access to NIBS clinical services and research operations during the current COVID-19 pandemic and possible future outbreaks, we develop and discuss a framework for balancing the importance of NIBS operations with safety considerations, while addressing the needs of all stakeholders. […] The document reflects the analysis of experts with domain-relevant expertise spanning NIBS technology, clinical services, and basic and clinical research - with an international perspective. […] We discuss COVID-19 considerations specifically for clinical (sub-)populations including pediatric, stroke, addiction, and the elderly. | 2020-05-29 |
| 32413609 | Here we evaluated the temporal variation of detection delay from symptoms onset to laboratory confirmation of SARS-CoV-2 in Hong Kong. | 2020-05-31 |
| 32413707 | We further present effects seen on psychiatric physicians in the setting of new and constantly evolving protocols where adjustment and flexibility have become the norm, training of residents, leading a team of professionals with different expertise, conducting clinical research, and ethical considerations. | 2020-05-16 |
| 32413736 | There are, however, no controlled clinical trials that show whether the use of corticosteroids can reduce COVID-19-related death. […] Tocilizumab, a monoclonal antibody against IL6, could confer clinical benefit in patients with high IL6 levels. | 2020-05-28 |
| 32414407 | We hope that our experiences will serve as pearls for otolaryngologists and other healthcare personnel working in institutes that serve large numbers of patients every day, particularly with regard to the sharing of clinical and administrative tasks during the COVID-19 pandemic. | 2020-05-20 |
| 32414522 | Both patients had no respiratory symptoms, they only complained of generalized weakness and were found to have elevated CK. | 2020-05-19 |
| 32414594 | To illustrate the clinical course and difficulties in early diagnosis of coronavirus disease 2019 (COVID-19) in patients after thoracic surgery. […] We retrospectively analyzed the clinical course of the first 11 patients diagnosed with COVID-19 after thoracic surgery in early January 2020. […] Postoperative clinical, laboratory, and radiologic records and the time line of clinical course were summarized. | 2020-05-29 |
| 32414711 | We propose that medications which inhibit the RAS ACE-dependent pathway may be beneficial in treating COVID-19 and should be explored in animal models and clinical trials. | 2020-05-16 |
| 32414757 | An ethical dilemma arises when one effective vaccine has been successfully developed against an epidemic disease and researchers seek to test the efficacy of another vaccine for the same pathogen in clinical trials involving human subjects. […] Third, clinical trials for novel vaccines may be at odds with efforts to control active outbreaks. | 2020-05-28 |
| 32414781 | Measurement of antibodies to SARS-CoV-2 will improve disease management if used correctly. | 2020-05-16 |
| 32414990 | As coronavirus changes the way we live our lives, clinical psychologists Matthew Whalley and Hardeep Kaur advise on managing wellbeing. | 2020-05-18 |
| 32415419 | Interestingly, some reports indicate that this wonder drug may be also beneficial for COVID-19 and accordingly, many clinical trials have begun. | 2020-05-19 |
| 32415472 | Stereotactic body radiotherapy for early prostate cancer reported safe toxicity profile and a good clinical outcome at the median follow-up of 5 years. | 2020-05-19 |
| 32415473 | SARS-CoV-2 pandemic represents a troubling health emergency but also a main challenge for the clinical governance of the system. […] We report our extended protocol, draft to manage clinical activities in our radiotherapy department, by minimizing contagion risks. […] A telephonic triage was performed to identify the presence of COVID-19 infection risk factors or symptoms. | 2020-05-25 |
| 32415481 | The main clinical manifestation of SARS-CoV-2 infection is pneumonia, cardiovascular complications have also been identified in the earliest reported cases from Wuhan, the epicenter of the outbreak. | 2020-05-21 |
| 32415548 | Human-to-human transmission of the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurs most often when people are in the incubation stage of the disease or are carriers and have no symptoms. | 2020-05-19 |
| 32415723 | General recommendations include those to minimise patient exposure to COVID-19, including the use of telehealth, avoidance of non-essential visits and minimisation of time spent by patients in infusion suites and other clinical areas. | 2020-05-16 |
| 32415727 | An ad hoc, validated questionnaire has 44 items investigating the following domains: knowledge of COVID-19 related to (a) epidemiology, (b) pathogenesis, (c) clinical symptoms, (d) preventive measures, and (e) attitudes. | 2020-05-28 |
| 32415733 | The current study aimed to exam posttraumatic stress symptoms (PTSS) of HCWs fighting for the COVID-19 and to evaluate their sleep quality after one-month stressful suffering. […] HCWs with higher exposure level also significantly rated more hyper-arousal symptoms (hazard ratio= 4.026, 95% CI= 1.233-13.140). | 2020-05-16 |
| 32415870 | Communication between all members of a research team is key to adapting the development of clinical trials to the context of the epidemiological crisis of coronavirus. | 2020-05-16 |
| 32415876 | The current COVID-19 pandemic has necessitated the more widespread use of telemedicine technology for clinical care, and has prompted consideration of its increased use for clinical trials. […] In this opinion piece, we describe the current state of telemedicine for recruitment, consenting and screening of participants for clinical trials. | 2020-05-16 |
| 32415888 | As we know, the likelihood of a favourable outcome in this disease relies heavily on patients presenting promptly after symptoms onset and on hospitals providing immediate access to optimized stroke care. | 2020-05-16 |
| 32415891 | With judicious risk stratification of patients based on clinical features of their OPMD and with consideration of ongoing mitigation efforts and regional pandemic impact, providers are able to safely care for their patients. […] The COVID-19 pandemic has required health care practitioners to make novel decisions that are new to us with development of creative pathways of care that focused on patient safety, mitigation efforts, and clinical management of disease processes. | 2020-05-16 |
| 32415914 | The objective of this study was to examine associations between exposure to coronavirus disease (COVID-19) news, risk perceptions, and depressive symptoms. […] After controlling for sociodemographic and socio-economic factors, news exposure was positively associated with depressive symptoms β = .11; 95% confidence interval (95%CI) = 0.02-0.20. […] Perceived vulnerability to COVID-19 can serve as a pathway through which exposure to COVID-19 news on mainstream media may be associated with depressive symptoms. | 2020-05-16 |
| 32415915 | We discuss possible effects on clinical birth defect diagnoses, routine birth defects surveillance system activities, and epidemiologic considerations, as well as opportunities for mitigating the impact of COVID-19. | 2020-05-16 |
| 32416017 | For example, faculty have had to move in-person classes online; conceptualize and offer alternative clinical experiences; and re-define how student performance is evaluated and graded. | 2020-05-16 |
| 32416028 | Neurological manifestations were extracted from the identified manuscripts and combined to provide a useful summary for the neurologist in clinical practice. […] Cranial nerve symptoms such as olfactory and gustatory dysfunctions are highly prevalent in patients with mild-to-moderate COVID-19 even without associated nasal symptoms and often present in an early stage of the disease. […] Physicians should be aware of the neurological manifestations in patients with COVID-19, especially when rapid clinical deterioration occurs. […] The neurological symptoms in COVID-19 patients may be due to direct viral neurological injury or indirect neuroinflammatory and autoimmune mechanisms. | 2020-05-16 |
| 32416069 | Significantly, our AI system identified important clinical markers that correlated with the NCP lesion properties. […] Together with the clinical data, our AI system was able to provide accurate clinical prognosis that can aid clinicians to consider appropriate early clinical management and allocate resources appropriately. | 2020-05-30 |
| 32416121 | Their demographic data, medical history, signs and symptoms of COVID-19, laboratory test results, and final outcomes of COVID-19 treatment were collected and analyzed. | 2020-05-31 |
| 32416154 | Using these principles, we then review management of gynecologic patients during the COVID-19 epidemic in the outpatient and operative and non-operative inpatient settings, as well as in clinical trials. | 2020-05-19 |
| 32416232 | The organization evaluated its pediatric clinical and wrap-around hospice services and rapidly migrated them to a virtual environment. | 2020-05-19 |
| 32416259 | Based on physical chemical analysis and free energies estimates, we can shed some light on the involved molecular recognition processes, their clinical aspects, the implications for drug developments, and suggest structural modifications on the CR3022 antibody that would improve its binding affinities for SARS-CoV-2 and contribute to address the ongoing international health crisis. | 2020-05-31 |
| 32416289 | The aim of the present observational study was to prospectively assess subjective neurological symptoms (sNS) in patients with SARS-CoV2 infection. […] These symptoms were present from the early phases of the disease. | 2020-05-22 |
| 32416290 | Using a mixed-method triangulation design (QUAN + QUAL), this study investigated and compared the mental status and inflammatory markers of 103 patients who, while hospitalized with mild symptoms, tested positive with COVID-19 and 103 matched controls that were COVID-19 negative. […] The severity of depression, anxiety, and post-traumatic stress symptoms (PTSS) was measured via an on-line survey. […] Results revealed that COVID-19 patients, when compared to non-COVID controls, manifested higher levels of depression (P < 0.001), anxiety (P < 0.001), and post-traumatic stress symptoms (P < 0.001). […] Levels of CRP, a peripheral inflammatory indicator, correlated positively with the PHQ-9 total score (R = .37, P = 0.003, Spearman’s correlation) of patients who presented symptoms of depression. […] Moreover, the change of CRP level from baseline inversely correlated with the PHQ-9 total score (R = -0.31, P = 0.002), indicative of improvement of depression symptoms. […] Thus, we recommend that necessary measures should be provided to address depression and other psychiatric symptoms for COVID-19 patients and attention should be paid to patient perceived stigma and coping strategies when delivering psychological interventions. | 2020-05-22 |
| 32416370 | The COVID-19 pandemics required several changes in stroke management and it may have influenced some clinical or functional characteristics. […] We analyzed admitted patients’ clinical features and outcomes between 9th March 2020 and 9th April 2020 (first month of lockdown), and compared them with patients admitted during the same period in 2019. […] Similar ‘symptoms alert-to-admission’ and ‘door-to-treatment’ times were observed. […] In conclusion, the adopted strategies for stroke management during the COVID-19 emergency have suggested being effective, while suffering a reduced and delayed reporting of symptoms. […] Therefore, we recommend raising awareness among the population against possible stroke symptoms onset. | 2020-05-29 |
| 32416412 | Severe SARS-CoV-2 infection (COVID-19) has a bad clinical outcome, and some reports emphasized the role of cytokine storm and dysfunctions of multiple organs. […] I hypothesized that the damage induced by free DNA is a reason for severe COVID-19, which can explain many symptoms of this disease, such as cytokine storm, acute respiratory distress syndrome (ARDS) and muscus plug, acute injuries of heart, liver and kidney, and some special symptoms of COVID-19. | 2020-05-26 |
| 32416415 | Numerous pathological, clinical and laboratory findings rise the similarity between moderate to severe COVID-19 and haemophagocytic lymphohistiocytosis (HLH). | 2020-05-26 |
| 32416433 | Every single Hospital and Department was forced to radically modify clinical practice decreasing or stopping daily activities. | 2020-05-29 |
| 32416567 | While seizures and status epilepticus have not been widely reported in the past five months since the onset of COVID-19 pandemic, patients with COVID-19 may have hypoxia, multiorgan failure, and severe metabolic and electrolyte disarrangements; hence, it is plausible to expect clinical or subclinical acute symptomatic seizures to happen in these patients. | 2020-05-29 |
| 32416600 | The aim of this study was to compare basic analytical and clinical performance of selected RT-PCR kits from seven different manufacturers (Altona Diagnostics, BGI, CerTest Biotec, KH Medical, PrimerDesign, R-Biopharm AG, and Seegene). […] Furthermore, we ran a panel of SARS-CoV-2-positive clinical samples (n = 13) for a preliminary evaluation of clinical sensitivity. […] Finally, we used clinical samples positive for non-coronavirus respiratory viral infections (n = 6) and a panel of RNA from related human coronaviruses to evaluate assay specificity. […] Using clinical samples, we observed some variations in detection rate between kits. | 2020-05-29 |
| 32416769 | Most patients with COVID-19 have mild symptoms, but about 5% develop severe symptoms, which can include acute respiratory distress syndrome, septic shock, and multiple organ failure. […] Kidney involvement is frequent, with clinical presentation ranging from mild proteinuria to progressive acute kidney injury (AKI) necessitating renal replacement therapy (RRT). […] Current approaches to prevention and management of AKI, and identification of potential indications for use of RRT and sequential extracorporeal therapies, are based mainly on clinical experience, and AKI strategies are adapted empirically to patients with COVID-19. […] International collaborative and cross-disciplinary research is needed to obtain adequate evidence to support current clinical approaches and to develop new approaches to management. | 2020-05-29 |
| 32416785 | We extracted information on comorbidities and prescriptions up to the month before index date (ie, current use) from electronic clinical records of both cases and controls. | 2020-05-31 |
| 32417070 | Despite high clinical knowledge and awareness (97.6%-99.2%), only 8.8% of pharmacists had reported suspected COVID-19 cases, however this varied significantly with pharmacist demographics (geographic region P < 0.001; pandemic training p < 0.001; position p = 0.019; age p = 0.046). | 2020-05-20 |
| 32417123 | In line with this concept, some methodological aspects of the use of the UVC sterilization of FFP/ cryoprecipitate-depleted FFP or immunoglobulins containing neutralizing antibodies for clinical use against COVID-19 are highlighted. […] Moreover, as some of these donors have already been in an induced-hypercoagulable state and prone to thrombosis and DVT, this strategy will be partially aimed at improving their health with the use of citrate based anticoagulants and removal of high molecular weight viscous components which contribute to the untoward clinical effects of DVT. | 2020-05-19 |
| 32417124 | The observed symptoms, the cause of which remains unclear, included impaired consciousness, skeletal muscle injury and acute cerebrovascular disease, and appeared more frequently in severe disease. | 2020-05-20 |
| 32417210 | The inflammatory cell levels were compared among patients according to clinical classifications, disease-associated phases, as well as one-month outcomes. […] Clinical classification-critically severe was the independently risk factor for lymphopenia (OR = 7.701, 95%CI:1.265-46.893, P = 0.027), eosinopenia (OR = 5.595, 95%CI:1.008-31.054, P = 0.049), and worse one-month outcome (OR = 8.984; 95%CI:1.021-79.061, P = 0.048). | 2020-05-31 |
| 32417248 | We describe the case of an Italian 7-week-old suckling baby SARS-CoV-2-positive only by cell culture method with no clinical suspicion and/or risk factors of SARS-CoV-2 infection. […] The patient was referred to the hospital with signs and symptoms of infection of the upper respiratory tract before the virus was spread to the province. | 2020-05-20 |
| 32417380 | Clinical characteristics and outcomes among patients with orthotopic heart transplant (OHT) with COVID-19 remain poorly described. […] Clinical data were obtained through review of the electronic medical record. […] Demographic, clinical, laboratory, radiologic, treatment, and mortality data were collected and analyzed. […] The mean age of patients was 61 ± 12 years, 100% were black males, and symptoms began 6 ± 4 days before admission. […] The most common symptoms included subjective fever (92%), shortness of breath (85%), and cough (77%). […] Presenting signs and symptoms in this cohort are similar to those in the general population. | 2020-05-26 |
| 32417674 | In clinical samples Xpert Xpress SARS-CoV-2 reaches an agreement of 100 % compared to all in-house RT-PCRs CONCLUSION: Cepheids GeneXpert Xpert Xpress SARS-CoV-2 is a valuable addition for laboratories in situations where rapid and accurate diagnostics are of the essence. | 2020-05-29 |
| 32417675 | The most frequently reported symptoms were cough 49% (95% CI: 42 - 55%) and fever 47% (95% CI: 41- 53%). | 2020-05-29 |
| 32417701 | Based on the different healthcare systems, human resources, infrastructure and medical emergencies that will warrant the conduct of clinical neurophysiology studies and the lack of a guide for the management of the situation, it was decided by an expert task force of the Latin American Chapter of the International Federation of Clinical Neurophysiology to carry out these guidelines for the protection of patient and healthcare professionals conducting clinical neurophysiological studies. | 2020-05-29 |
| 32417768 | A novel Coronavirus (SARS-CoV-2) causing a cluster of respiratory infections (Coronavirus Disease 2019, COVID-19) first discovered in Wuhan, China is responsible for a new illness that has been found to affect the lungs and airways of patients with associated symptoms of fever, cough and shortness of breath. […] Government of member states of ECOWAS need to prepare themselves by building capacity as well as implement evidenced-based steps to mitigate this rapidly evolving pandemic by testing persons presenting with symptoms (fever, cough and shortness of breath), isolating and treating those found positive, tracing and quarantining contacts, implementing social distancing as well as optimizing human and material endowment to allow healthcare workers offer safe quality clinical care for affected patients to prevent secondary infection among healthcare workers. | 2020-05-17 |
| 32417802 | Case reports of pregnant patients demonstrate a clinical presentation comparable to non-pregnant adults, but evidence of vertical transmission to the fetus is controversial. | 2020-05-17 |
| 32417878 | In early March 2020, a tornado destroyed the health system’s warehouse for storage of most clinical supplies, including personal protective equipment and fluids. […] After an initial plan, ongoing needs include adjustment in patient care activities if significant staff losses occur, when and how to resume clinical activities, and how to best utilize the resources accumulated. | 2020-05-29 |
| 32417996 | To search for evidence base for using BCG in the fight against COVID-19 and the possible impact of these clinical trials on urology practice. […] A literature review about the basis of the ongoing clinical trials using BCG against COVID-19, as well as the use of BCG in urology and if there are any implications of these trials on our practice. […] Based on data from some epidemiological studies, there are some current clinical trials on the use BCG as a possible prophylactic vaccine against SARS CoV-2 which can affect urology practice. […] The ongoing clinical trials using BCG against COVID-19 can affect our urology practice. | 2020-05-20 |
| 32418029 | The COVID-19 pandemic has spread rapidly, forcing some drastic changes not only in our daily lives, but also in our clinical and surgical activities. | 2020-05-20 |
| 32418146 | Main themes encompassed testing strategies and results (n = 4), changes in use of current therapeutics (n = 3), preventive measurements of transmission and management of COVID-19 (n = 3), and changes in standard clinical care (n = 3). | 2020-05-20 |
| 32418181 | Although the clinical evidence supporting their use is scarce, the off label use of these drugs has spread very quickly in face of the progression of the epidemic and the high mortality rate in susceptible populations. | 2020-05-20 |
| 32418199 | Currently, many interventional strategies are being explored in ongoing clinical trials, encompassing many drug classes and strategies, including antiviral drugs, biological response modifiers and RAAS inhibitors. | 2020-05-21 |
| 32418216 | Evidence-based studies are still expected to formulate clinical decisions for pediatric patients. […] In this review, we evaluated the demographic, clinical, laboratory and imaging features from 2,597 pediatric patients of COVID-19 that reported recently. | 2020-05-17 |
| 32418232 | Objective Structured Clinical Examinations (OSCEs) in United States Medical Schools traditionally involve students interviewing and examining standardized patients (SP) in clinical skills labs. | 2020-05-17 |
| 32418240 | Social distancing, shortages of personal protective equipment, and clinical care needs necessitated that students be removed from the clinical setting. | 2020-05-17 |
| 32418288 | Covid-19 infection has the potential for targeting the central nervous system and several neurological symptoms have been described in patients with severe respiratory distress. […] A progressive clinical improvement along with a reduction of CSF parameters was observed after high-dose steroid treatment, thus arguing for an inflammatory-mediated brain involvement related to Covid-19. | 2020-05-17 |
| 32418307 | In addition to respiratory symptoms, COVID-19 can present with gastrointestinal complaints suggesting possible faeco-oral transmission. […] Search terms for Medline included ‘clinical’, ‘faeces’, ‘gastrointestinal secretions’, ‘stool’, ‘COVID-19’, ‘SARS-CoV-2’ and ‘2019-nCoV’. […] Duration of faecal viral shedding ranged from 1 to 33 days after a negative nasopharyngeal swab with one result remaining positive 47 days after onset of symptoms. | 2020-05-17 |
| 32418377 | The recorded information included clinical data and indicators of kidney-related laboratory tests. Results: The average age of patients was (65.2±17.1) years, and 34.5% (30/87) patients were ≥ 75 years old and 31.0% (27/87) patients were 60~74 years old. | 2020-05-17 |
| 32418446 | We report a series of febrile pediatric patients with acute heart failure potentially associated with SARS-CoV-2 infection and the multisystem inflammatory syndrome in children (MIS-C) as defined by the US Centers for Disease Control. Methods: Over a two-month period contemporary with the SARS-CoV-2 pandemic in France and Switzerland, we retrospectively collected clinical, biological, therapeutic, and early outcomes data in children who were admitted to pediatric intensive care units in 14 centers for cardiogenic shock, left ventricular dysfunction and severe inflammatory state. Results: Thirty-five children were identified and included in the study. […] Gastrointestinal symptoms were prominent. | 2020-05-18 |
| 32418460 | Due to its highly contagious nature and unprecedented global spread, its aggressive clinical presentation and the lack of effective treatment, SARS-CoV-2 infection is causing the losses of thousands of lives and imparting unparalleled strains on healthcare systems around the world. | 2020-05-18 |
| 32418532 | The main SARS-CoV-2-related COVID-19 symptoms/diseases reported hitherto are hypertension, atherosclerosis, thrombosis (coagulopathy), diarrhea, glaucoma, anosmia, ageusia, skin lesions (dermatitis), autoimmune inflammation of the central nervous system, and damages to various organs such as the lung, heart, kidney, and testicle [1, 2, 14]. […] Since RAS appears to be central in COVID-19 symptoms/diseases, selective targeting of key component(s) of this system might be appropriate to treat RAS-dependent disorders. […] Recombinant ACE2 (under clinical trials) is also considered as a decoy for the recognition and competitive binding to the spike (S) glycoprotein of SARS-CoV-2 [9, 10]. | 2020-05-18 |
| 32418715 | Clinical investigations in patients with COVID-19 has shown a strong upregulation of cytokine and interferon production in SARS-CoV2- induced pneumonia, with an associated cytokine storm syndrome. | 2020-05-23 |
| 32418728 | First, the clinical observations of the French Pharmacovigilance Network showed that severe bacterial infections can occur even after a short NSAID treatment, and even if the NSAID is associated with an antibiotic. […] Therefore, in case of infection, symptomatic treatment with NSAIDs for non-severe symptoms (fever, pain, or myalgia) is not to be recommended, given a range of clinical and scientific arguments supporting an increased risk of severe bacterial complication. | 2020-05-20 |
| 32418734 | In the field of functional urology, there are clinical situations with a high risk of complication if management is delayed and a great heterogeneity of advisable reprogramming times after cancellation. […] But the 3 AFU committees covering the field of functional urology have identified three clinical situations in which surgical procedures that can be maintained during the COVID-19 epidemic (priority level A): conclusion of a neuromodulation test in progress (implantation or explantation), botulinum toxin A bladder injections for unbalanced neurologic bladder, cystectomy and ileal conduit for urinary fistula in perineal bedsore or refractory unbalanced neurologic bladder with acute renal failure and vesico-enteric or prostato-pubic fistulas. […] The joint functional urology committees indicate that there are specific clinical situations in this field that demand non-delayed care during COVID crisis. | 2020-05-20 |
| 32418804 | The novel coronavirus is formally named SARS-CoV-2 and the clinical disease state resulting from an infection is known as COVID-19. | 2020-05-22 |
| 32418852 | Our study aimed to evaluate the association of liver injury and gastrointestinal symptoms (GIS) with the progression of COVID-19. | 2020-05-20 |
| 32418885 | No evidence from randomized clinical trials (RCTs) that a treatment may ameliorate the clinical outcome of patients with COVID-19 exists with the only exception of preliminary evidence from remdesivir trials. | 2020-05-28 |
| 32418894 | The review elaborates the mechanism of action, safety (side effects, adverse effects, toxicity) and details of clinical trials for chloroquine and hydroxychloroquine to benefit the clinicians, medicinal chemist, pharmacologist actively involved in controlling the pandemic and to provide therapeutics for the treatment of COVID-19 infection. | 2020-05-29 |
| 32419164 | Lessons learned involved presenting clinical issues, supervision, and working with children and adolescents. | 2020-05-29 |
| 32419272 | Research priorities include infection control, epidemiology, clinical characterization and management, detection methods (including viral RNA detection, viral antigen detection, and serum antibody detection), therapeutics (neutralizing antibody and small molecule drugs), vaccines, and SARS-CoV-2 pathogenesis. | 2020-05-18 |
| 32419401 | Typical patient presentation with respiratory symptoms of COVID-19 was seen in less than 50% of patients, whereas abnormal findings on chest imaging investigations were detected in 93.5% of the study population. […] The chest radiography facility, resuscitation rooms, and triage area were moved to locations outside the ED, and a new surveillance protocol was applied to determine the factors warranting quarantine, including symptoms, chest radiographic findings, and exposure to a source of infection. | 2020-05-19 |
| 32419495 | The Head and Neck Department clinical and surgical activity was substantially reduced. | 2020-05-18 |
| 32419524 | The in vitro database, adverse effects, and potential toxicities of these drugs are reviewed regarding their feasibility of clinical prescription for the treatment of patients with COVID-19. […] In future, clinical trials regarding a combination of potentially effective drugs against SARS-CoV-2 need to be conducted to establish the optimal regimen for the treatment of patients with moderate-to-severe COVID-19. | 2020-05-18 |
| 32419538 | In Italy, all the non-urgent clinical appointments (such as primary prevention visits and elective surgeries) have been postponed. | 2020-05-18 |
| 32419544 | Clinical presentation in neonates is nonspecific, commonly observed are temperature instability, respiratory distress, poor feeding, lethargy, vomiting and diarrhea. | 2020-05-18 |
| 32419558 | Objective: The 2019 coronavirus disease (COVID-19) outbreak that began in China has turned into a pandemic that threatens global health, thereby prompting the concentration of studies and clinical routines on treating and preventing the disease. | 2020-05-18 |
| 32419564 | Although most people have no or mild symptoms, COVID-19 spreads aggressively and can lead to ARDS rapidly in a proportion of individuals. | 2020-05-18 |
| 32419568 | SARS-CoV-2 samples obtained within 24 hours were positive, supporting prior infection despite relatively limited early symptoms of COVID-19. […] Unusual clinical and radiographic characteristics included hemorrhagic abscess with blood of varying age in the first, intracranial epidural abscess in the second, radiographic signal consistent with hemorrhagic or thrombotic phenomena, retro-maxillary antral fat changes, and meningeal enhancement or extension in both cases. | 2020-05-18 |
| 32419667 | Each of these death attributes is a well-documented correlate of bereaved survivors’ symptoms of depression, anxiety, and anger. | 2020-05-18 |
| 32419694 | We report a young Thai man from the Thai-Myanmar border suffering from 2 days of fever and myalgia without respiratory tract signs or symptoms. […] Fever and nonspecific symptoms and laboratory results in early COVID-19 may be difficult to distinguish from tropical infectious diseases, especially when respiratory signs and symptoms are absent. […] This fact necessitates vigilant awareness in clinical investigation, management, and infection control, especially in tropical resource-limited settings. | 2020-05-18 |
| 32419703 | The primary objective of the Scleroderma Patient-centered Intervention Network COVID-19 Home-isolation Activities Together (SPIN-CHAT) Trial is to evaluate the effect of a videoconference-based program on symptoms of anxiety. […] Secondary objectives include evaluating effects on symptoms of depression, stress, loneliness, boredom, physical activity, and social interaction. | 2020-05-18 |
| 32419721 | In the absence of data on the effect of immunosuppressants on COVID-19, these data could be used to make clinical decisions on initiation and continuation of immunosuppressive medications during this pandemic. | 2020-05-22 |
| 32419751 | The 2019 novel Corona Virus pandemic beginning from Wuhan, China primarily affects the respiratory tract but its has impacted clinical practice across a range of specialities including neurology. | 2020-05-22 |
| 32419771 | The clinical manifestations and spectrum of symptomatic disease range from moderate to critical presentations. | 2020-05-18 |
| 32419848 | Critical to this effort is the participation of informaticians who typically work on other basic science or clinical problems. | 2020-05-22 |
| 32419854 | All information (symptoms, signs, management, complications) are taken from the other pandemic infections (SARS, MERS). | 2020-05-26 |
| 32419876 | The platelet count reflects the thrombocyte turnover, acting as a sensitive indicator of illness severity that is of great clinical utility to monitor a quickly changing health condition of patients affected by aggressive viral infections. […] We collected the clinical characteristics and laboratory data of patients. | 2020-05-22 |
| 32419879 | During the pandemic, insofar as an asymptomatic patient may be infected and contagious, the same precautions must be employed whether the patient be ill with, suspected of having, or without any clinical evidence of COVID-19 infection. | 2020-05-18 |
| 32419887 | The pandemic involving COVID-19 caused by the SARS-CoV-2 coronavirus, due to its severe symptoms and high transmission rate, has gone on to pose a control challenge for healthcare systems all around the world. | 2020-05-22 |
| 32419998 | The clinical and logistical challenges created by the COVID-19 public health crisis are clear, but the solutions to these issues are less readily apparent. […] While the full impact of the pandemic remains to be seen, the aim of this paper is to provide a structural framework to optimize delivery of neurosurgically oriented radiosurgery with proposed clinical workflow strategies. | 2020-05-22 |
| 32420073 | The epidemic spread of COVID-19 has brought great challenges to the clinical practice of thoracic oncology. […] Outpatient clinics need to strengthen the differential diagnosis of initial symptoms, pulmonary ground-glass opacity (GGO), consolidation, interstitial and/or interlobular septal thickening, and crazy paving appearance. | 2020-05-22 |
| 32420305 | Based on a positive nasopharyngeal swab nucleic acid test result and clinical characteristics, the patient was diagnosed with COVID-19. | 2020-05-22 |
| 32420523 | We performed a comprehensive investigation of the clinical features of hospitalised patients with schizophrenia with or without suspected COVID-19 in Hubei Province, China. […] To explore the clinical characteristics of hospitalised patients with schizophrenia with suspected COVID-19 in Hubei Province, China. 21 hospitalised patients with schizophrenia with suspected COVID-19 (COVID-19 suspected group) in the isolation ward of a mental health hospital in Wuhan and 30 hospitalised patients with schizophrenia (clean group) in the general ward of another mental health hospital in Yichang were recruited. […] We retrospectively reviewed their clinical characteristics, laboratory findings and chest CT results before 21 February 2020. […] We also compared the emotional and mental symptoms between the two groups. […] Medical records revealed that 21 COVID-19 suspected patients were transferred to the isolation ward between 30 January 2020 and 15 February 2020. […] 12 (57.1%) patients showed abnormalities on chest CT before onset of respiratory symptoms. […] Setting up an independent isolation ward for hospitalised psychiatric patients who are suspected to have symptoms of COVID-19 helped control the spread of the epidemic. | 2020-05-22 |
| 32420607 | The severity of COVID-19 disease has a wide range and varies from asymptomatic to critical severe, clinical researches reported that 10-15% of the patients were in the severe situation and required a great deal of attention of treatment and nursing (WHO-China-Joint-Mission 2020). | 2020-05-18 |
| 32420637 | Over thousand clinical trials with COVID-19 patients are already listed in ClinicalTrials.com, some of them for assessing the utility of therapeutics approved for other conditions. […] However, clinical trials take many months, and are typically done with small cohorts. […] A much faster and by far more efficient method for rapidly identifying approved therapeutics that can be repurposed for treating COVID-19 patients is data mining their past and current electronic health and prescription records for identifying drugs that may protect infected individuals from severe COVID-19 symptoms. […] Data mining of prescription records of COVID-19 patients will not cancel the need for conducting controlled clinical trials, but could substantially assist in trial design, drug choice, inclusion and exclusion criteria, and prioritization. | 2020-05-19 |
| 32420674 | This review analyses information on progression of the pandemic in the past 3 months and systematically discusses the characteristics of SARS-CoV-2019 virus including its epidemiologic, pathophysiologic, and clinical manifestations. | 2020-05-18 |
| 32420705 | For general practitioners (and other first-line responders), a clinical evaluation at any given time merely provides a snapshot of the patient’s condition. | 2020-05-20 |
| 32420710 | There has been an urgent need to determine clinical characteristics of Polish patients with laboratory‑confirmed severe acute respiratory syndrome coronavirus 2 (SARS‑CoV 2) infection in the clinical setting. […] We retrospectively assessed 169 consecutive patients with laboratory‑ confirmed COVID‑ 19 with regard to their clinical manifestations, radiological findings, treatment, complications, and outcomes. […] The most common symptoms on admission were fever (42%), shortness of breath (35%), and fatigue (33%). | 2020-05-29 |
| 32420720 | This concise scientific statement includes references to the most recent and relevant guidelines and clinical trials that shape management decisions. | 2020-05-18 |
| 32420751 | All patients received appropriate supportive care and regular clinical and laboratory monitoring. […] Main evaluation indicators included improvement of clinical symptoms such as fever, cough and diarrhea after hospitalization; pathogen nucleic acid test result of respiratory tract and fecal specimens of the patient after hospitalization, and change of chest CT examination after hospitalization. […] Our results suggest that NHM could improve the clinical symptoms of COVID-19 patients and may be effective in treating COVID-19; thus, a larger, prospective, randomized, controlled clinical trial should be conducted to further evaluate the adjuvant efficacy of NHM in the treatment of COVID-19. | 2020-05-18 |
| 32420777 | When admitted to the hospital on 24 February 2020, she had no clinical manifestations. | 2020-05-18 |
| 32420788 | With the spread of the novel coronavirus, the outpatient lines of hospitals have mostly shut down, which means that routine clinical diagnosis and treatment for autoimmune bullous diseases patients have been disturbed. | 2020-05-18 |
| 32420822 | During public health crises including the COVID-19 pandemic, resource scarcity and contagion risks may require health systems to shift-to some degree-from a usual clinical ethic, focused on the well-being of individual patients, to a public health ethic, focused on population health. | 2020-05-18 |
| 32420863 | Although coronavirus infections in pets are known to be predominantly related to the gastrointestinal tract, it has been observed that there are human-to-animal transmissions in this outbreak and some animals have similar symptoms to humans. | 2020-05-18 |
| 32420926 | They were asked whether they would change daily practice and make clinical decisions according to POC tests. […] Still, 40.3% of respondents would change daily practice because of such tests, and 38.5% would make clinical decisions based of their results. […] Actual understanding of specificity and sensitivity of POC tests was not associated with assessed behavioral outcomes: main positive effectors were identified in perceived reliability and usefulness of rapid tests, acknowledging the existence of official recommendations, understanding the limited clinical implications of POC tests, and working as occupational physicians were characterized as negative effectors. | 2020-05-22 |
| 32420928 | Pursuing the purposes inherent in the concept of humanization of care and assistance, with the aim of offering Apulian citizens a complementary, but also fundamental, service in clinical-therapeutic assistance to the patient affected by COVID-19, in the hope of improving the quality of care, also in relation to the perception of the user, the Strategic Management of the AOU Policlinico of Bari has launched an experimental project that fits into the context of care quality, a crucial and not negligible issue, despite the extreme difficulties dictated by the ongoing medical emergency. […] The experimental project proposes an innovative clinical-organizational model which, through Information and Communications Technology (ICT), intends to make the management of COVID-19 patients optimal, safe and better, in all the spheres that jointly define the concept of Health. | 2020-05-22 |
| 32420929 | Infected children may be asymptomatic or present fever, dry cough, fatigue or gastrointestinal symptoms. […] The CDC recommends that clinicians should decide to test patients based on the presence of signs and symptoms compatible with COVID-19. 42 children (the majority < 5 years of age) were referred, to our Pediatric Department, as possible cases of COVID-19 infection. […] At first presentation, the most frequent signs and symptoms were: fever (71.4%), fatigue (35.7%) and cough (30.9%). […] Testing people who meet the COVID-19 suspected case definition criteria is essential for clinical management and outbreak control. | 2020-05-22 |
| 32420931 | Compared to GPs with absent or mild depressive symptoms (PHQ-9 < 10), GPs reporting moderate to severe depressive symptoms (N=30, 22.9%; PHQ-9 ≥ 10) reported more helplessness (96.7% vs. | 2020-05-26 |
| 32420935 | COVID-19 is a novel virus with an unpredictable course and many uncertainties about its biological, clinical and epidemiological characteristics. […] COVID-19 is a game changer and calls for a revision of IHR as well as a more biological, clinical and community-cantered preparedness strategy. | 2020-05-26 |
| 32420936 | Potential drug targets are emerging as the result of a fast-evolving understanding of SARS-CoV-2 virology, host response to the infection, and clinical course of the disease. […] Ongoing clinical trials are also emphasized. | 2020-05-26 |
| 32420937 | As concerns serological testing, promising information can be garnered from preliminary investigations, showing that the vast majority of COVID-19 patients seem to develop a sustained immune response against the virus, characterized especially by emergence of anti-SARS-CoV-2 IgG and IgA, 1 to 2 weeks after the onset of fever and/or respiratory symptoms. | 2020-05-26 |
| 32420938 | The clinical presentation following human infection ranges from a mild upper respiratory tract infection to severe acute respiratory distress syndrome and sepsis. | 2020-05-26 |
| 32420939 | As other diseases, the COVID-19 presentation in older patients is often atypical with less severe and unspecific symptoms. […] The application of additional instruments would be necessary to facilitate and personalize the clinical approach, not only based on diseases but also on functional status. […] We developed a check-list of respiratory, gastro-intestinal and other less-specific symptoms, summarized in a table and easily to be filled-up by patients, nurses and general practitioners. […] As second step, we reported the clinical phases of this disease. | 2020-05-26 |
| 32420940 | Imaging might play an important role in clinical decision making by supporting rapid triage of patients with suspected COVID-19 and assessing supervening complications, such as super-added bacterial infection and thrombosis. | 2020-05-26 |
| 32420941 | The aim of this review is to underline the epidemiological, clinical and management characteristics in children affected by COVID-19. […] We searched Pubmed, from January to April 2020, for the following search terms: “COVID-19”, “children”, “SARS-COV2”, “complications”, “epidemiology”, “clinical features”, focusing our attention mostly on epidemiology and symptoms of COVID-19 in children. […] Usually, infants and children present milder symptoms of the disease with a better outcome than adults. | 2020-05-26 |
| 32420942 | The disease has a range of clinical presentations in children, for which the potential need for further investigation of myocardial injury and cardiovascular issues should be kept in mind to avoid misdiagnosing severe clinical entities. | 2020-05-22 |
| 32420943 | The clinical symptoms of COVID-19 include fever, fatigue, cough, breathing difficulty that may lead to respiratory distress; a small population of patients may have diarrhea, nausea or vomiting. […] As the outbreak continues to spread worldwide, attention has switched toward determinants of clinical manifes- tations and disease severity. | 2020-05-22 |
| 32420946 | In children with food allergy the visits should be limited to those that are unequivocally needed on clinical basis. | 2020-05-22 |
| 32420954 | Anosmia and dysgeusia have been reported as particular symptoms.4,5 Notably, these sensory symptoms seem to have a peculiar trend, such as usually precede the onset of respiratory symp- toms. […] So, they have been defined as “sentinel” symptoms. | 2020-05-22 |
| 32420958 | Efficacy and safety of sofosbuvir in treatment of COVID-19 may be considered in future clinical studies. | 2020-05-22 |
| 32420961 | Clinical records and laboratory tests were retrospectively reviewed. | 2020-05-22 |
| 32421102 | In view of the high homology of gene sequences between SARS-CoV-2 S-protein RBD domain and SARS virus, as well as their similarities in pathogenesis and clinical manifestations, we established SARS-CoV-2 S-protein model using Swiss-Model. | 2020-05-22 |
| 32421258 | To investigate the ocular manifestations and clinical characteristics of COVID-19 patients caused by SARS-CoV-2 in Wuhan, China. […] Information on demographic characteristics, exposure history, ocular symptoms, eye drop medication, eye protections, chronic eye diseases, systemic concomitant symptoms, radiologic findings and SARS-CoV-2 detection in nasopharyngeal swabs by real-time PCR was collected from questionnaires and electronic medical records. […] The other ocular symptoms, including increased conjunctival secretion, ocular pain, photophobia, dry eye and tearing, were also found in patients with conjunctival congestion. […] Similar to the published studies, the most common clinical symptoms were fever, cough and fatigue. […] Conjunctival congestion is one of the COVID-19-related ocular symptoms, which could occur as the initial symptoms. | 2020-05-18 |
| 32421381 | Demographic and clinical data, laboratory data, including ultrasound scans of the lower extremities, and outcome variables were obtained, comparisons were made between DVT and non-DVT groups. Results: Of the 143 patients hospitalized with COVID-19 (aged 63 ± 14 years; 74 [51.7%] man), 66 patients developed lower extremity DVT (46.1%, included 23 [34.8%] with proximal DVT and 43 [65.2%] with distal DVT). | 2020-05-18 |
| 32421497 | The global COVID-19 pandemic has become one of the largest clinical and operational challenges faced by emergency medicine, and our EDs continue to see increased volumes of infected patients, many of whom are not only ill, but acutely aware and fearful of their circumstances and potential mortality. | 2020-05-28 |
| 32421539 | Patients with Coronavirus Disease 2019 (COVID-19) often have clinical characteristics, such as chest tightness and dyspnea. […] However, our clinical observations showed that although some patients had significant chest distress and dyspnea, the lesions that were observed in the lungs during computed tomography were milder and not completely consistent with clinical symptoms. […] We analyzed the clinical characteristics, laboratory test results, and imaging findings of these patients. | 2020-05-22 |
| 32421541 | Due to a scarcity of information in this area of clinical practice, the purpose of this paper is to explain how to deliver aerosolized medications to mild-, sub-intensive, and intensive-care patients with COVID-19 and how to protect staff from exposure to exhaled droplets during aerosol therapy. | 2020-05-22 |
| 32421627 | Besides, biosensors are also powerful tools for effective assessment of clinical progress and to provide alertness on severity or critical trends of infection. | 2020-05-29 |
| 32421686 | We identified eight topics, namely, actions and recommendations, fighting misinformation, information and knowledge, healthcare system, symptoms and illness, immunity, testing, and infection and transmission. […] The remaining tweets discussed information about symptoms associated with COVID-19 (8%), immunity (7%), testing (6%), and virus infection and transmission (5%). | 2020-05-18 |
| 32421703 | The performance of the nomogram regarding the C-index, calibration, discrimination, and clinical usefulness was assessed. […] We established an early warning model incorporating clinical characteristics that could be quickly obtained on admission. | 2020-05-21 |
| 32421877 | in the end of 2019, a series of pneumonia cases emerged in China, with clinical presentations greatly resembling viral pneumonia, caused by Covid-19 o SARS-CoV-2. | 2020-05-18 |
| 32422057 | If clinical suspicion is high, infection should not be ruled out on the basis of RT-PCR alone, and the clinical and epidemiologic situation should be carefully considered. | 2020-05-23 |
| 32422076 | Systematic macroscopic, histopathologic, and viral analysis (SARS-CoV-2 on real-time polymerase chain reaction assay), with correlation of pathologic and clinical features, including comorbidities, comedication, and laboratory values. | 2020-05-20 |
| 32422078 | Detailed clinical data of those pregnancies with COVID-19 were retrospectively collected and analyzed. Results: Twenty-seven laboratory or clinically confirmed SARS-CoV-2 infection pregnant women (4 early pregnancies included) and 24 neonates born to the 23 late pregnant mothers were analyzed. […] On admission, 46.2% (13/27) of the patients had symptoms, including fever (11/27), cough (9/27) and vomiting (1/27). | 2020-05-18 |
| 32422081 | Case reports and case series depicting the clinical effects of the causative virus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have been published, yet few demonstrate the cytopathologic alterations of this disease. […] We present a clinical-pathological correlation report of a previously healthy Hispanic woman with laboratory-confirmed COVID-19 who had typical features of acute respiratory distress syndrome (ARDS), and also showed cardiac abnormalities thought to represent fulminant viral myocarditis. […] Congruent with the ARDS clinical impression, autopsy findings were remarkable for extensive and markedly severe acute lung injury consistent with viral pneumonia, characterized by diffuse alveolar damage, pulmonary infarction, severe pulmonary edema, desquamation of pneumocytes with intraalveolar aggregation, and pneumocyte morphological alterations suspicious for viral cytopathic effect. […] However, there was incongruence between the clinical impression and the cardiovascular pathology findings in that viral myocarditis was not detected on histopathologic evaluation. […] This case highlights the importance of pathologic corroboration of the clinical impression and, in addition, illuminates the key role autopsy plays during a pandemic by providing valuable insight into viral pathology in tissues. | 2020-05-18 |
| 32422178 | The symptoms associated with COVID-19 are diverse, ranging from mild upper respiratory tract symptoms to severe acute respiratory distress syndrome. | 2020-05-22 |
| 32422201 | Case interviews were done to describe timing of onset and nature of symptoms and to identify and classify contacts as high risk (had cumulative face-to-face contact with a confirmed case for ≥15 min, direct contact with secretions or body fluids of a patient with confirmed COVID-19, or, in the case of health-care workers, had worked within 2 m of a patient with confirmed COVID-19 without personal protective equipment) or low risk (all other contacts). […] High-risk contacts were ordered to stay at home in quarantine for 14 days and were actively followed up and monitored for symptoms, and low-risk contacts were tested upon self-reporting of symptoms. […] We defined fever and cough as specific symptoms, and defined a prodromal phase as the presence of non-specific symptoms for at least 1 day before the onset of specific symptoms. […] Patient 0 was a Chinese resident who visited Germany for professional reasons. 16 subsequent cases, often with mild and non-specific symptoms, emerged in four transmission generations. […] Although patients in our study presented with predominately mild, non-specific symptoms, infectiousness before or on the day of symptom onset was substantial. | 2020-05-22 |
| 32422204 | We aimed to identify demographic and clinical risk factors for testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within the Oxford Royal College of General Practitioners (RCGP) Research and Surveillance Centre primary care network. | 2020-05-22 |
| 32422233 | The electronic medical records were reviewed at least three weeks after admission. […] Fever (86%), cough (76.5%), and dyspnea (68%) were the three most common symptoms. 24% died during hospitalization (BMI < 25 kg/m2: 31.6%, BMI 25-34 kg/m2: 17.2%, BMI ≥ 35 kg/m2: 34.8%, p = 0.03). | 2020-05-28 |
| 32422280 | A significant relationship exists between air pollution and SARS-CoV-2 infection, as more severe COVID-19 symptoms occur in smokers; comorbid conditions due to obesity or excess ectopic fat accumulation as underlying risk factors for severe COVID-19 strongly encourage the virus/ACE2 receptor-ligand interaction concept. | 2020-05-27 |
| 32422287 | Presenting symptoms, patient’s comorbidities, and postoperative course complicated with cardiac and respiratory failure leading to adverse outcome are discussed in this case report. | 2020-05-30 |
| 32422320 | Interestingly, a prior preclinical study showed protective effects of p38 inhibition in a SARS-CoV mouse model. […] A number of p38 inhibitors are in the clinical stage and should be considered for clinical trials in serious COVID-19 infection. | 2020-05-31 |
| 32422341 | The search strategy included clinical date published until May 9, 2020. | 2020-05-31 |
| 32422349 | Further clinical trials are required to ascertain the need for early therapeutic anticoagulation or fibrinolytic therapy to address this state of fibrinolysis shutdown. | 2020-05-22 |
| 32422376 | We describe the diagnosis, clinical course, and management of the case, including the respiratory failure at presentation, the progression to a scenario characterized by profound inflammatory dysregulation similar to that observed during macrophage activation syndrome, and the clinical improvement after treatment with the IL-1 receptor antagonist anakinra. | 2020-05-20 |
| 32422384 | Based on the clinical data, approved cases are divided into four classes including mild, moderate, severe, and critical. […] This review focuses on currently available information on the etiology, clinical symptoms, diagnosis, and mechanism of action of COVID-19. | 2020-05-22 |
| 32422410 | To evaluate the performance of an ultra-fast single-tube nucleic acid isothermal amplification detection assay for SARS-CoV-2 RNA using clinical samples from multiple centers. […] The clinical performance of RT-RAA assay was evaluated using 947 clinical samples from five institutions in four regions of China, and the approved commercial real-time fluorescent RT-PCR (qRT-PCR) kits were used for parallel detection. | 2020-05-22 |
| 32422426 | All clinicians should be aware that the presentation of SARS-CoV-2’s symptoms goes far beyond respiratory and sensorial dimensions and involves psychosensorial and neurological dimensions; these clinical observations could shed light on the neurobiological substrates involved in COVID-19 disease. | 2020-05-26 |
| 32422501 | Our objective was to explore the impact of the COVID-19 pandemic on somatic symptoms among Chinese college and primary school students, to provide reference data pertaining to the mental health of this population in the context of a public health emergency. […] In February and March 2020, we explored the somatic symptoms and concerns regarding COVID-19 of 399 college and primary school students in Sichuan Province using the Somatic Self-rating Scale (SSS) and a novel questionnaire, respectively. […] The incidence of somatic symptoms among college students was 34.85 (mild, 26.26%; moderate, 8.59%). […] The incidence of somatic symptoms in primary school students was 2.39% (all mild). […] Among the entire cohort, concern regarding COVID-19 was positively correlated with the occurrence of somatic symptoms. […] Somatic symptoms were more likely among college students expressing greater concern regarding the threat to life and health posed by COVID-19, and the efficacy of prevention and control measures. […] Among primary school students, only the concern for life and health was associated with a higher likelihood of somatic symptoms. | 2020-05-27 |
| 32422545 | Common reported symptoms included hyposmia, headaches, weakness, altered consciousness. | 2020-05-28 |
| 32422662 | This model is a combination of clinical assessment by using vital parameters and Manchester triage scale (MTS). | 2020-05-18 |
| 32422693 | In France, COVID-19 wasn’t known to cause cutaneous manifestations before April 6th 2020, when an alert about possible associated skin symptoms was raised to the general public and the professional social network2-4 . | 2020-05-18 |
| 32422983 | Autopsy should be considered mandatory to define the exact cause of death, thus providing useful clinical and epidemiologic information as well as pathophysiological insights to further provide therapeutic tools. | 2020-05-19 |
| 32423024 | COVID-19 is being increasingly investigated through virology, epidemiology, and clinical management strategies. […] Therapies include new agents that are currently tested in several clinical trials, in addition to other medications that have been repurposed as antiviral and immune-modulating therapies. […] This review aims to summarize rationalized pharmacotherapy considerations in COVID-19 patients in order to serve as a tool for health care professionals at the forefront of clinical care during this pandemic. […] All the reviewed therapies require either additional drug development or randomized large-scale clinical trials to be justified for clinical use. | 2020-05-19 |
| 32423027 | Results recently published on the clinical evaluation of those drugs are compiled in this brief report, although complete data are still impatiently awaited. | 2020-05-19 |
| 32423059 | Accumulating clinical observations raised hypotheses to explain why some patients develop more severe disease while others only manifest mild or no symptoms. | 2020-05-19 |
| 32423250 | Databases such as MEDLINE, EMBASE, CENTRAL, Scopus, Web of Science, ClinicalTrials.gov, Chinese Knowledge Resource Integrated Database and Chinese Clinical Trial Registry were searched on 20 March 2020. | 2020-05-19 |
| 32423285 | Understanding these less well-characterized symptoms may help develop measures for estimating early markers of disease prevalence and/or resolution. | 2020-05-19 |
| 32423292 | Retrospective assessment was performed to the response and management strategy developed to transform the clinical and academic enterprise. […] The departmental structure was reorganized along new clinical teams to effectively meet the system directives for provision of otolaryngology care and support for inpatient cases of COVID-19. […] A surge deployment schedule was developed to assist frontline colleagues with clinical support as needed. […] Educational and research efforts were redirected to focus on otolaryngology care in the clinical context of the COVID-19 crisis. | 2020-05-23 |
| 32423293 | Professional otolaryngologic societies across the world have proposed limiting patient care to time-sensitive and urgent matters; however, limited literature is available to describe how this transient change in philosophy may translate to clinical practice. | 2020-05-19 |
| 32423296 | This evidence-based clinical consensus is designed to guide practitioners of pediatric otolaryngology for common scenarios during this time. […] A clinical consensus on 6 common scenarios in pediatric otolaryngology developed with evidence-based strategies. | 2020-05-19 |
| 32423297 | Contemporary medical practice is grounded in rigorous scientific evidence in concert with best clinical practices and informed shared decision making with patients. […] It becomes especially important that we continue to use reasonable, informed clinical judgment in discussing the various options with patients. | 2020-05-19 |
| 32423298 | Since March 10, the first day of the lockdown in Italy, diagnostic and therapeutic procedures were limited to emergency and oncology cases, while outpatient procedures and clinical examinations were temporarily suspended to limit virus diffusion and to reallocate personnel into wards dedicated to COVID-19. | 2020-05-19 |
| 32423324 | However, there is a robust pre-clinical and clinical data regarding inhibitor effect of this pathway on the acute or chronic viral infections. […] Here, we report the clinical course of coronavirus infection 2019 infection of a patient in whom older aged, having multiple co-morbidities, and taking nivolumab for metastatic malignant melanoma. […] We think that this good clinical course of coronavirus infection 2019 infection may be related to blockade of PD-1/PDL-1 pathway with nivolumab. | 2020-05-19 |
| 32423357 | We sought to better determine prevalence, severity, and timing of OD in COVID-19 relative to other sinonasal and pulmonary symptoms. | 2020-05-23 |
| 32423359 | Since the COVID-19 pandemic began, many individuals have noted acute loss of smell and/or taste, although not all patients with these symptoms are tested for COVID-19. […] To better characterize all patients with these rare symptoms, a national survey was created. […] Most but not all patients had other symptoms suggestive of COVID-19 at the time of chemosensory loss. […] Despite its inclusion as a major symptom of COVID-19 by the CDC (Centers for Disease Control and Prevention), respondents with additional CDC-defined symptoms associated with COVID-19 were statistically more likely to be tested/diagnosed than those without. | 2020-05-19 |
| 32423368 | We evaluated sociodemographic and clinical characteristics associated with intubation and prolonged intubation for acute respiratory failure secondary to COVID-19 infection. […] In addition to clinical signs of respiratory distress, patients with COVID-19 who are older, male, or diabetic are at higher risk of requiring intubation. | 2020-05-23 |
| 32423435 | Therefore, we aimed to investigate the clinical and chest CT imaging characteristics of COVID-19 in preschool children. […] From January 26, 2020 to February 20, 2020, the clinical and initial chest CT imaging data of eight preschool children with laboratory-confirmed COVID-19 from two hospitals were retrospectively collected. […] Accurate diagnosis requires a comprehensive evaluation of epidemiological, clinical, laboratory and CT imaging data. | 2020-05-26 |
| 32423449 | Coronavirus disease 2019 (COVID-19) is typically associated with fever and respiratory symptoms. […] The in vivo safety of local and intravenous administration of MSCs has been demonstrated in multiple human clinical trials, including studies of acute respiratory distress syndrome (ARDS). […] This literature summary reviews the scientific rationale and need for clinical studies of adipose-derived stem cells and other types of mesenchymal stem cells in the treatment of patients who suffer with COVID-19. | 2020-05-28 |
| 32423584 | The primary endpoint was time to clinical improvement up to day 28, defined as the time (in days) from randomisation to the point of a decline of two levels on a six-point ordinal scale of clinical status (from 1=discharged to 6=death) or discharged alive from hospital, whichever came first. […] Remdesivir use was not associated with a difference in time to clinical improvement (hazard ratio 1·23 [95% CI 0·87-1·75]). […] Although not statistically significant, patients receiving remdesivir had a numerically faster time to clinical improvement than those receiving placebo among patients with symptom duration of 10 days or less (hazard ratio 1·52 [0·95-2·43]). […] In this study of adult patients admitted to hospital for severe COVID-19, remdesivir was not associated with statistically significant clinical benefits. […] However, the numerical reduction in time to clinical improvement in those treated earlier requires confirmation in larger studies. | 2020-05-29 |
| 32423664 | In the process of management of COVID-19 infections, close attention should be paid on both lung and cardiovascular damage, especially on those with only symptoms of cardiovascular diseases. | 2020-05-22 |
| 32423700 | We recommend establishing an alternative feasible system, such as self-isolation by contact history in non-endemic community and by symptoms in endemic community, not relying on the PCR examination, to minimize this ongoing COVID-19 outbreak. […] Further rapid accumulation of knowledge including incubation period, clinical course and types of transmission is warranted to control this outbreak. | 2020-05-22 |
| 32423833 | However, several important clinical considerations have been discussed to inform oncology nursing care and practice. | 2020-05-22 |
| 32423888 | The study was aimed to describe the clinical characteristics and evaluate the dynamic changes of chest CT features in the first three weeks in the common type fo COVID-19 pneumonia patients in Jiangsu Province. 307 patients infected SARS-CoV-2 classified as common type were enrolled in the study. 628 chest CT scans were divided into three groups based on the time interval between symptoms and chest CT scan. […] The clinical characteristics were descriptively analyzed.The chest CT features were quantitatively evaluated. […] Fever (69.1%) and cough (62.8%) were common symptoms. | 2020-05-31 |
| 32423899 | In this article, we propose a guidance to the management of pancreatic cancer during the pandemic, prioritised according to a three-tiered framework, and based on expert clinical judgement and magnitude of benefit expected from specific interventions. | 2020-05-21 |
| 32423903 | Urgent clinical trials are needed to evaluate the role of anticoagulation in COVID-19. | 2020-05-19 |
| 32423908 | We obtained clinical data for 41 consecutive outpatient kidney transplant recipients with known or suspected coronavirus disease 2019. | 2020-05-30 |
| 32423911 | This case demonstrates tension pneumothorax as a possible complication of suspected COVID-19 and emphasises the importance of thorough history-taking and clinical examination. | 2020-05-20 |
| 32423917 | Although over 90% of infected individuals are asymptomatic or manifest noncritical symptoms and will recover from the infection, those individuals presenting with critical symptoms are in urgent need of effective treatment options. […] Emerging data related to mechanism of severity and potential therapies for patients presenting with severe symptoms are scattered and therefore require a comprehensive analysis to focus research on developing effective therapeutics. | 2020-05-19 |
| 32423922 | Every month, DTB scans sources of information on treatments, disease management and other healthcare topics for key items to bring to our readers’ attention and help them keep up to date. | 2020-05-19 |
| 32424063 | The COVID-19 pandemic has generated an imbalance between the clinical needs of the population and the effective availability of advanced life support (ALS) resources. […] Lacking national guidance or public coordination, each hospital has been forced to put forth independent and autonomous triage protocols, most of which were, nonetheless, based on common ethical principles and clinical criteria. […] However, controversial, non-clinical criteria have also been defended by Spanish scientific societies and public institutions, including setting an age cut-off value for unilaterally withholding ALS, using ‘social utility’ criteria, prioritising healthcare professionals or using ‘first come, first served’ policies. […] The problems posed by subjective, non-clinical criteria will also be discussed. | 2020-05-28 |
| 32424327 | We conducted a systematic review of articles referenced in PubMed, Cochrane Library, Web of Science and Chinese Clinical Trial Register (ChiCTR) from December 20, 2019 to April 6, 2020, providing information on the presence of SARS-CoV-2 in cornea, conjunctiva, lacrimal sac, and tears. […] We excluded ongoing clinical studies as for unobtainable conclusive results. | 2020-05-25 |
| 32424329 | Ocular and systemic signs and symptoms were recorded from their medical history. […] The average disease time from initiation of symptoms was 3.27 days, range: 1-7 days. | 2020-05-25 |
| 32424429 | Collected data included clinical history, laboratory results, treatment, and review of all available imaging. | 2020-05-19 |
| 32424503 | Coronaviruses (CoV) are viruses widely known to cause severe respiratory distress due to the prominent clinical symptoms presented. […] These symptoms, which include fever and dry cough, are frequently found in individuals with CoV infection. | 2020-05-25 |
| 32424603 | The Clinical Blood Sciences Laboratory (CBSL) plays a key role in supporting the monitoring and management of patients with COVID-19 disease. […] We provide a test menu for clinical laboratories to ensure the effective monitoring, management and prognostication of COVID-19 patients in hospital. | 2020-05-25 |
| 32424616 | Three patients of coronavirus disease (COVID-19) showed the symptoms of olfactory dysfunction. […] Clinical characteristics and treatment were retrospective analyzed. […] Olfactory disorders are uncommon symptoms of COVID-19 in China. | 2020-05-22 |
| 32424745 | The aim of this study was to systematically review main clinical characteristics and outcomes of SARS-CoV-2 infections in pediatric age. […] The most commonly described symptoms were fever (51.6%) and cough (47.3%). […] Larger epidemiological and clinical cohort studies are needed to better understand possible implications of COVID-19 infection in children.What is Known:• A novel Coronavirus has been recently identified as responsible for a new Severe Acute Respiratory Syndrome (SARS-CoV-2) spreading globally. | 2020-05-22 |
| 32425000 | COVID-19 represents a spectrum of clinical manifestations that typically include fever, dry cough, and fatigue, often with pulmonary involvement. […] Meanwhile, recent research has revealed critical aspects of SARS-CoV-2 biology and disease pathogenesis; other studies have focused on epidemiology, clinical features, diagnosis, management, as well as drug and vaccine development. | 2020-05-20 |
| 32425002 | This study investigates the epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19) patients in Zhejiang Province who did or did not have a history of Wuhan exposure. […] We collected data from medical records of confirmed COVID-19 patients in Zhejiang Province from Jan. 17 to Feb. 7, 2020 and analyzed epidemiological, clinical, and treatment data of those with and without recorded recent exposure in Wuhan. […] From the perspective of epidemiological and clinical characteristics, there was no significant difference between COVID-19 patients with and without Wuhan exposure history. | 2020-05-20 |
| 32425003 | This study summarizes and compares clinical and laboratory characteristics of 34 patients admitted to the intensive care unit (ICU) for complications from coronavirus disease 2019 (COVID-19) at the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China from Jan. 22 to Mar. […] Clinical features of COVID-19 patients were described and the parameters of clinical characteristics between the two groups were compared. | 2020-05-20 |
| 32425004 | To better understand the clinical characteristics of COVID-19 and more effectively prevent and control this disease, we retrospectively analyzed four representative cases of COVID-19 that had recently been screened and diagnosed in our emergency department. | 2020-05-20 |
| 32425006 | We designed an internet-based integrated intervention and evaluated its efficacy on depression and anxiety symptoms in patients infected by SARS-CoV-2. | 2020-05-20 |
| 32425007 | The recently emerged novel coronavirus pneumonia, named the coronavirus disease 2019 (COVID-19), shares several clinical characteristics with severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), and spread rapidly throughout China in December of 2019 (Huang et al., 2020). […] Here we report the clinical course of a pregnant woman with COVID-19. | 2020-05-20 |
| 32425008 | Recent articles have uncovered genomic characteristics and clinical features of COVID-19 (Chan et al., 2020; Chang et al., 2020; Guan et al., 2020; Zhu et al., 2020), while our understanding of COVID-19 is still limited. […] Here, we examined two cases in which nucleic acid test results were inconsistent with clinical and radiological findings, leading to suboptimal care. | 2020-05-20 |
| 32425010 | In accordance with the national standard “Regulation for Cleaning and Disinfection Technique of Flexible Endoscope (WS507-2016),” we improved the workflow of endoscope reprocessing including the selection of chemicals in an effort to ensure quality control throughout the clinical management towards COVID-19 patients. | 2020-05-20 |
| 32425013 | Despite the exact pathophysiological mechanism of coronavirus-induced thromboembolism needs to be further investigated, this finding suggests that it is good practice to assess the risk of thrombosis in COVID-19 patients to improvethe clinical management in terms of anticoagulation therapy. | 2020-05-20 |
| 32425014 | In some cases, cardiovascular symptoms can also be the first and only manifestation of SARS-CoV-2 infection. | 2020-05-20 |
| 32425152 | We review the most promising candidate medicines, including available evidence, clinical recommendations and current options for access. […] Our concluding remarks stress the importance of administering off-label and investigational drugs in the setting of clinical trials, or at least in standardized scenarios, to generate as much scientific knowledge as achievable while engaging in the best efforts to treat patients and save lives. | 2020-05-19 |
| 32425183 | The COVID-19 post-lockdown period and the subsequent progressive withdrawal of the quarantine measures are currently allowing the gradual resumption of the ordinary clinical activities, which have been suppressed during the COVID-19 pandemic. […] In order to ensure the safety of patients and healthcare providers, therefore, it is mandatory to stratify the risk of post-COVID-19 pandemic infection during the clinical and instrumental evaluation of cardiac patients, who are at low risk for COVID-19. | 2020-05-20 |
| 32425198 | This registry will enroll confirmed COVID-19 patients and persons under investigation (PUI) with new ST-segment elevation or new onset left bundle branch block (LBBB) on the ECG with clinical suspicion of myocardial ischemia. […] We will compare demographics, clinical findings, outcomes and management of these patients with a historical control group of over 15,000 consecutive STEMI activation patients from the Midwest STEMI Consortium using propensity matching. […] The primary clinical outcome will be in- hospital major adverse cardiovascular events (MACE) defined as composite of all-cause mortality, stroke, recurrent MI, and repeat unplanned revascularization in COVID-19 confirmed or PUI. […] The multicenter NACMI registry will collect data regarding ST elevation on ECG in COVID-19 patients to determine the etiology and associated clinical outcomes. | 2020-05-22 |
| 32425199 | It is important to have a knowledge of potential cardiotoxic effects of these drugs before using them for COVID-19 patients for better allocation of healthcare resources and improvement in clinical outcomes. | 2020-05-22 |
| 32425222 | In Sainte Anne Hospital (GHU PARIS Psychiatrie & Neuroscience, Paris, France) we have observed a lower incidence of symptomatic forms of COVID-19 among patients than among our clinical staff. | 2020-05-19 |
| 32425224 | Given the considerable presence of type 2 diabetes mellitus in the current population, the pandemic is a health issue that requires an effort to provide better responses to our patients who are more vulnerable to the onset of infection and who are candidates for presenting more severe symptoms. | 2020-05-19 |
| 32425234 | We sought to characterize the clinical course of COVID-19 among IBD patients and evaluate the association between demographics, clinical characteristics, and immunosuppressant treatments on COVID-19 outcomes. | 2020-05-22 |
| 32425237 | This review provides a brief understanding of pathophysiology, clinical features, diagnosis and management of COVID-19 and highlights the current knowledge as well as best practices for orthopaedic surgeons. | 2020-05-22 |
| 32425244 | Since COVID-19 symptoms are aspecific and may resemble a common cold, if it should come back with a seasonal pattern and coincide with the influenza season, this would be particularly challenging, overwhelming and straining the healthcare systems, particularly in resource-limited contexts, and would increase the likelihood of nosocomial transmission. […] In the present study, we devised a mathematical model focusing on the treatment of people complaining of influenza-like-illness (ILI) symptoms, potentially at risk of contracting COVID-19 or other emerging/re-emerging respiratory infectious agents during their admission at the health-care setting, who will occupy the detection kits causing a severe shortage of testing resources. | 2020-05-22 |
| 32425249 | According to previous reports, diabetes seems to be a risk factor which worsens the serious clinical events caused by COVID-19. | 2020-05-20 |
| 32425259 | Therefore, we conducted a study to investigate the susceptibility of COVID-19 in IgG4-RD patients in Hubei province, and to characterize the clinical manifestation of COVID-19 in IgG4-RD patients. […] Medical history, clinical symptoms, laboratory tests, CT imaging, and treatment were obtained through a standardized data collection form, and then independently reviewed by two investigators. 2 of 91 cases were infected with COVID-19. […] The symptoms such as fever and cough and radiologic features were similar to other COVID-19 patients. | 2020-05-29 |
| 32425260 | To investigate the incidence of COVID-19 in a cohort of adult and paediatric patients with rheumatic diseases receiving targeted biologic and synthetic disease modifying anti-rheumatic drugs (tDMARDs) and to explore the possible effect of these treatments in the clinical expression of COVID-19. […] Demographics, disease activity, COVID-19 related symptoms and contact history data were obtained from the start of the 2020 pandemic. […] Suspected cases were defined following WHO criteria and compared to those without compatible symptoms. 959 patients with rheumatic diseases treated with tDMARDs were included. | 2020-05-29 |
| 32425267 | In order to preserve its integrity, we propose an enhanced triage prior to the admission to a Covid-free unit including not only routine questions on fever and respiratory symptoms but also non-respiratory symptoms, history of exposure, and a survey about the social and geographic origin of the patient. | 2020-05-22 |
| 32425268 | This is a single institution retrospective observational study at a tertiary referral medical center examining women who underwent primary hysterectomy or trachelectomy for clinical stage IA-IIA invasive cervical cancer between 2000 and 2017 (N = 217). | 2020-05-22 |
| 32425269 | Patients with COVID-19 hospitalized from February 29th to April 09th, 2020 were analyzed for baseline clinical and laboratory findings at admission and during the disease. | 2020-05-19 |
| 32425283 | The outcome of these simulations is in accordance with literature data measured in the clinical environment. […] The new IABP module is easy to manage and can be used as a training tool in a clinical setting. | 2020-05-27 |
| 32425289 | The current clinical guidelines on the management of cardiorespiratory arrest do not include recommendations for situations that apply to this context. | 2020-05-19 |
| 32425292 | This protocol consists of two simple validated clinical tools for identifying nutritional risk and loss of muscle mass and function -Malnutrition Universal Screening Tool (‘MUST’) and SARC-F (5-item questionnaire: Strength, Assistance with walking, Rise from a chair, Climb stairs and Falls) - and additional practical guidance on nutritional interventions for family physicians. | 2020-05-22 |
| 32425294 | In this review we compare the clinical features, diagnosis, and pathogenesis of COVID-CSS with other hematological CSS, namely secondary hemophagocytic lymphohistiocytosis (sHLH), idiopathic multicentric Castleman disease (iMCD), and CAR-T cell therapy associated Cytokine Release Syndrome (CRS). […] We review the evidence for cytokine blockade and attenuation in these known CSS as well as the emerging literature and clinical trials pertaining to COVID-CSS. | 2020-05-22 |
| 32425304 | Children had mild symptoms and hardly infected other children or adults. […] The cellular immune system of children differs from that of adults may be the keystone of atypical clinical manifestations or even covert infection. | 2020-05-27 |
| 32425307 | This immuno-modulatory effect of MSCs could hold potential to manage a patient with severe symptoms of COVID 19 infection due to a dysfunctional adaptive immune system. | 2020-05-22 |
| 32425328 | Although respiratory symptoms usually dominate the clinical presentation, COVID-19 is now known to also have potentially serious cardiovascular consequences, including myocardial injury, myocarditis, acute coronary syndromes, pulmonary embolism, stroke, arrhythmias, heart failure, and cardiogenic shock. | 2020-05-22 |
| 32425334 | •Whole genomes of 93 clinical samples from COVID-19 patients were analysed to find the primer and probe binding sites. | 2020-05-26 |
| 32425336 | To analyze clinical and thin-section computed tomographic (CT) data from the patients with coronavirus disease (COVID-19) to predict the development of pulmonary fibrosis after hospital discharge. | 2020-05-22 |
| 32425337 | The clinical, laboratory and CT imaging were available to evaluate in all patients. […] The 4 patients (11.76%) with no symptoms were identified during screening for close contacts, who had typical CT findings. | 2020-05-22 |
| 32425338 | Considering the broad spectrum of clinical manifestations and the increasing worldwide burden of the disease, there is an urgent need to rapidly scale up the diagnostic capacity to detect COVID-19 and its complications. | 2020-05-29 |
| 32425356 | •This case shows COVID-19-related drug eruption and specific clinical features. […] •Drug eruption preceding COVID-19 symptoms may facilitate early diagnosis. | 2020-05-22 |
| 32425361 | 64.1%, P<0.001) and clinical cure (78.9% vs. […] In light of the safety and effectiveness profiles, LH capsules could be considered to ameliorate clinical symptoms of Covid-19. | 2020-05-22 |
| 32425429 | On the advent of COVID-19 pandemic, it has been acknowledged by the British Orthopaedic Association (BOA) emergency COVID-19 and the National Health Service England (NHSE) guidelines to manage urgent orthopaedic and trauma conditions pragmatically balancing optimum treatment of patients against clinical safety with resource utilization . | 2020-05-22 |
| 32425470 | The virus, SARS-Coronavirus-2 (2-SARS-CoV-2), is particularly virulent in the elderly who can develop symptoms and become mortally ill within days of contracting the virus. […] To date, most of the medical literature, including Center for Disease Control guidelines, has relied on three necessary symptoms in making the diagnosis of COVID-19: fever, cough and shortness of breath. […] We present four cases of elderly patients who developed altered mental status as their presenting symptom without associated fever or respiratory symptoms. | 2020-05-22 |
| 32425487 | Stress, sleep disorders and depressive symptoms stand out. | 2020-05-19 |
| 32425491 | The purpose of this review is to study the most relevant and current information on the pathogen, as well as epidemiology, pathology, clinical features, transmission, prevention, and treatment of the disease. | 2020-05-19 |
| 32425636 | Clinical characteristics, laboratory findings, treatment and outcome were retrieved. […] The median duration of viral shedding (the number of days from symptoms onset till the successive negative detection of SARS-CoV-2 RNA) was 17 days (interquartile range [IQR], 12 to 21). | 2020-05-19 |
| 32425638 | With no specific treatments being available for treating COVID-19 patients, the global medical, scientific, pharma and funding communities have rapidly initiated over 500 COVID-19 clinical on a range of antiviral drug regimens, biologics, repurposed drugs in various combinations. | 2020-05-19 |
| 32425646 | We assessed the prevalence, clinical presentation and outcomes of dementia among subjects hospitalized for COVID19 infection. […] Clinical records of each patients admitted to the hospital with a diagnosis of COVID19 infection were retrospectively analyzed. […] Diagnosis of dementia, modalities of onset of the COVID-19 infection, symptoms of presentation at the hospital and outcomes were recorded. […] Among patients diagnosed with dementia the most frequent symptoms of onset were delirium, especially in the hypoactive form, and worsening of the functional status. […] The clinical presentation of COVID-19 in subjects with dementia is atypical, reducing early recognition of symptoms and hospitalization. | 2020-05-22 |
| 32425648 | The antibody positive rates were very low in the first five days after initial onset of symptoms, and then rapidly increased as the disease progressed. […] However, the positive rates of viral RNA maintained above 60% in the first 11 days after initial onset of symptoms, and then rapidly decreased. […] Before the 11th day after initial onset of symptoms, nucleic acid test is key for confirmation of viral infection. | 2020-05-23 |
| 32425649 | However, the clinical characteristics and co-infection with other respiratory pathogens of patients with COVID-19 and the factors associated with severity of COVID-19 are still limited. | 2020-05-22 |
| 32425651 | Therefore, in this review, we outline the epidemiology, clinical symptoms, diagnosis, treatment, prevention, possible immune response and role of thymus in children to combat the COVID-19 outbreak. | 2020-05-22 |
| 32425653 | There is a similarity of clinical features of TB and malaria, with those used to track COVID-19 cases. […] This coupled with institutional mistrust and misinformation might result in many patients with clinical features similar to those of COVID-19 being hesitant to voluntarily seek care in a formal health facility. | 2020-05-22 |
| 32425657 | In response, many EUA assays have become available for clinical laboratories, and more recently, the point of care device, Abbott ID NOW. | 2020-05-22 |
| 32425712 | This paper presents an evidence-based strategy for improving clinical outcomes in COVID-19. […] These two aspects of the disease suggest two different patterns of clinical emphasis that seem on the surface to be not entirely concordant. […] Thus, one clinical strategy involves supporting patient innate and adaptive immune responses early in the time course of illness, with the goal of improving the timeliness, readiness, and robustness of both the innate and adaptive immune responses. […] Thus, the second clinical strategy is to prevent or mitigate excessive inflammatory response to prevent the cytokine storm associated with high mortality risk. […] Clinical support for immune system pathogen clearance mechanisms involves obligate activation of immune response components that are inherently inflammatory. […] This puts the goals of the first clinical strategy (immune activation) potentially at odds with the goals of the second strategy(mitigation of proinflammatory effects). | 2020-05-22 |
| 32425713 | Therefore, in response to the estimated potential impact of COVID-19 on Johns Hopkins Aramco Healthcare (joint venture between Saudi Aramco and Johns Hopkins Medicine International), several initiatives were taken by the hospital’s inpatient pharmacy department with focus on infection control, staffing, meeting clinical operational challenges, ethics, increased utilization of automation, and maintenance of employee wellness to prepare for this challenge. […] The key focus areas include development of an institutionalized COVID-19 protocol, measures to improve infection control when handling and dispensing medications, modified staffing plan, system changes in peri-operative areas, keeping pharmacy professionals updated about new and scientific researches, increased utilization of automation, clinical interventions by pharmacist ensuring appropriate utilization of medications while monitoring for drug-drug interactions, adverse drug event prevention, and preparing for handling drug shortages. | 2020-05-19 |
| 32425950 | Non-ICU patients with total T cells counts lower than 800/μL may still require urgent intervention, even in the immediate absence of more severe symptoms due to a high risk for further deterioration in condition. | 2020-05-21 |
| 32425996 | However, there is increasing evidence that many patients with COVID-19 are asymptomatic or have only mild symptoms, but they are able to transmit the virus to others. | 2020-05-22 |
| 32426001 | Five cases with a clinical history of biopolymers in the gluteal region that developed iatrogenic allogenosis (IA) are presented here. […] The 5 cases were put under colchicine treatment for IA crisis and had non-specific symptoms (headache, cough without dyspnoea, and arthralgias) with a positive SARS-CoV-2 test. […] Their close contacts had mild to severe symptoms and three of them died. | 2020-05-19 |
| 32426066 | Concerns regarding conferences/networking opportunities (63%), clinical experience (59%), and board exam scores (42%) were most frequently cited. 76% of M3s reported at least one cancelled/postponed neurosurgery rotation. | 2020-05-19 |
| 32426089 | This compact overview of recommendations by the EUFOREA expert teams on allergic airway diseases and AIT is based on investigation of the current COVID-19 literature in association with the key words above and shared clinical experience of the experts involved. | 2020-05-19 |
| 32426090 | A registry of cases of COVID-19 in patients with severe asthma, including those treated with biologics, will help to address a clinical challenge where we have more questions than answers. | 2020-05-19 |
| 32426099 | This tool aims to help behavior analysts make thoughtful clinical decisions to maintain continuity of care for the vulnerable population with autism spectrum disorders, while adhering to safety measures that provide protection to society. | 2020-05-22 |
| 32426111 | This document will highlight some of the issues facing providers, patients, and the pulmonary arterial hypertension community in real-time as the COVID-19 pandemic is evolving and is intended to share expected common clinical scenarios and best clinical practices to help the community at-large. | 2020-05-22 |
| 32426200 | We noted a correlation between cytokine release, encephalopathy, and the onset of stroke symptoms. | 2020-05-22 |
| 32426209 | However, it has been also speculated about that using immunmodulators could be an advantage for the clinical prognosis. […] Therefore, several immunmodulators are currently being tested as potential treatment for COVID-19. : In this paper we report on a patient that has been treated with type 1 interferon for multiple sclerosis who developed COVID-19. : Despite using immunmodulator, the symptoms of the patient at hospitalization were mild and he did not show elevated D-dimer, and there was no lymphopenia. […] He was discharged to home-quarantine with no symptoms. : This report supports the idea of using type 1 interferon in the treatment could be effective in COVID-19 affected patients. | 2020-05-22 |
| 32426220 | Triage urgency was determined based on clinical assessment of urgency with which a patient would require medical treatment or surgical intervention. […] Clinical conditions were classified into six categories of: 1) Venous thromboembolism (VTE), 2) Chronic Venous Disease (CVD), 3) Vascular anomalies, 4) Venous trauma 5) Venous compression and 6) Lymphatic disease. […] VELTAS aims to standardise the triage of patients with venous and lymphatic disease or vascular anomalies by providing an international consensus-based classification of clinical categories and triage urgency. | 2020-05-22 |
| 32426303 | Clinical findings have been reviewed to confirm or rule out SARS-CoV2 infection. […] Patients with COVID 19 can present few symptoms of the disease, and in PET-CT studies both presymptomatic and almost asymptomatic patients can be detected, so nuclear medicine physicians should take special attention to the pulmonary evaluation of PET-CT studies. | 2020-05-19 |
| 32426374 | We reviewed the inflammatory features and current promising treatments of COVID-19 as well as cardiovascular anti-inflammatory therapies that have been verified in previous clinical trials with positive outcomes. […] We recommend to take the experiences in cardiovascular anti-inflammatory therapy as references in the management of COVID-19 and conduct related clinical trials, while the clinical translation of novel treatments from preclinical studies or in vitro drug screening should proceed with caution due to unguaranteed efficacy and safety profiles. | 2020-05-22 |
| 32426441 | Prioritisation schemes take into account the patient’s wishes, clinical frailty, pre-existing chronic condition, along with severity and evolution of acute condition. | 2020-05-19 |
| 32426556 | We synthesized information from clinical evidence, existing recommendations from the NCCN, and variations in practice between multiple academic tertiary cancer centers to develop the proposed guidance. | 2020-05-22 |
| 32426560 | The patient displayed no fever or upper respiratory tract signs or symptoms. […] Patient was tested positive for Covid 19 virus and later during hospitalization developed more typical fever and respiratory symptoms that were managed medically. | 2020-05-22 |
| 32426575 | •The risk of thromboembolic events in COVID-19 is substantial•Pulmonary embolism should be considered in cases of clinical deterioration•Management of clot in transit is controversial. | 2020-05-19 |
| 32426576 | Furthermore, anaesthesiologic, surgical and clinical data were evaluated in both groups. | 2020-05-26 |
| 32426653 | Several case series from Italy and China have highlighted the lung ultrasound findings of this disease process and may demonstrate its clinical utility during the current pandemic. […] A multi-organ point-of-care ultrasound (POCUS) evaluation was used on the return visit and assisted clinical decision-making. […] We believe that when applied efficiently and safely a POCUS exam can reduce clinical uncertainty and potentially limit the use of other imaging modalities when treating patients with COVID-19. | 2020-05-22 |
| 32426749 | Data selection included preclinical and clinical studies detailing neurologic manifestations of viral respiratory infections. […] Having an understanding of the direct neurotropism of such viruses is imperative to understanding pathogenesis, clinical presentation, and potential treatment paradigms aimed at improving morbidity and mortality. | 2020-05-22 |
| 32426751 | This review will briefly examine the clinical presentation and important immunology of viral pneumonia with a focus on severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019). […] Given the rapidly emerging pandemic associated with the novel severe acute respiratory syndrome coronavirus 2 causing coronavirus disease 2019, it is important to review the clinical presentation and immunologic changes associated with viral pneumonia. […] Symptoms of viral pneumonia include common respiratory tract infection symptoms of cough, fever, and shortness of breath. […] Coronavirus disease 2019 clinical presentation is typical of viral pneumonia with an increased prevalence of early pulmonary infiltrates and lymphopenia. | 2020-05-22 |
| 32426755 | We propose that this dynamic situation calls for a parallel “Clinical Distancing” in which we as a medical culture go against many of our fundamental instincts and, at least in the short term, begin to reduce unnecessary patient-care contacts for the benefit of our patients and our ability to continue to provide care to those who need it most. […] In this commentary, we provide specific recommendations for the rapid implementation of clinical distancing techniques. | 2020-05-22 |
| 32426897 | A prominent clinical feature of severe Covid-19 infection is respiratory failure associated with pulmonary coagulopathy. | 2020-05-19 |
| 32426957 | The paper reviews aspects of COVID-19 that pertain to rheumatology, including symptoms and signs akin to those observed in rheumatic disorders, risk of infection or severe course of the disease in patients with a pre-existing rheumatic disease and those receiving antirheumatic or immunosuppressive medication as well as potential applications of antirheumatic or anticytokine therapeutic strategies that are already applied in rheumatology (including chloroquine, hydroxychloroquine, tocilizumab, baricitinib, and others) for patients with COVID-19. | 2020-05-19 |
| 32427000 | Objective: The aim of this study was to provide recommendations for improving the design of subsequent studies through analysis of the registered coronavirus disease 2019 (COVID-19) clinical trials. Methods: A retrospective analysis of 189 trials retrievals achieved on February 20, 2020. Results: A total of 189 trials are included in the study. […] Primary outcome type most used: 45.8% with clinical characteristics and 21.4% with virological. […] Furthermore, similar or repeated research and small sample studies that have less promise in gains of new information have possibly led to a shortage of recruitable patients and become a barrier to the completion of large multicenter clinical trial studies. | 2020-05-19 |
| 32427134 | It appears that around one third of COVID-19 patients admitted to intensive care units (ICU) for respiratory difficulties exhibit neurologic symptoms. | 2020-05-22 |
| 32427166 | The usefulness of existing approaches for re-purposing range from computational modeling to clinical trials. […] Proposed here is a new but simple concept that would capitalize on the opportunity presented by the on-going natural experiment involving the collection of data from epidemiological surveillance screening and diagnostic testing for clinical treatment. | 2020-05-22 |
| 32427171 | This is a clinical review of these options and their applicability in adult COVID-19 patients. | 2020-05-22 |
| 32427173 | A novel coronavirus (COVID-19) causing acute illness with severe symptoms has been isolated in Wuhan, Hubei Province, China. | 2020-05-22 |
| 32427184 | Constraining the presence of interns in the affiliated hospital has impacted the integrity of delivering the learning outcomes of each clinical rotation. […] In this paper, we present the experience of four faculty preceptors in restructuring the advanced pharmacy practice experience in different clinical settings, including critical care, infectious diseases, cardiology, and internal medicine, in order to reduce the risk of contracting COVID-19 at a large academic medical institution in Saudi Arabia. | 2020-05-22 |
| 32427216 | All patients undergo a clinical and virologic diagnostic process before admittance and receive psychosomatic psychotherapeutic inpatient care, possibly beginning under quarantine conditions. | 2020-05-22 |
| 32427279 | An early short course of methylprednisolone in patients with moderate to severe COVID-19 reduced escalation of care and improved clinical outcomes. | 2020-05-19 |
| 32427334 | Analysis of daily samples from six patients with COVID-19 showed anti-nucleocapsid and spike antibodies appearing between day 8 and day 14 after initial symptoms. | 2020-05-19 |
| 32427361 | The clinical severity ranged from mild to requiring hospitalization. | 2020-05-19 |
| 32427403 | Clinical features of patients, ventilator withdrawal after tracheostomy, surgical complications, and nosocomial infection of the health care workers associated with the tracheostomy were analyzed. | 2020-05-19 |
| 32427529 | In nearly 1 month, with a rapidly expanding corona virus disease 2019 (COVID-19), telemedicine has been transformed into an essential service for delivering routine clinical care. | 2020-05-19 |
| 32427569 | Healthcare workers (HCWs) are at the highest risk of contracting the novel coronavirus (SARS-CoV-2), with 12% of total coronavirus cases confirmed among them recently. 80% of the infected persons show only mild, moderate symptoms or stay asymptomatic. | 2020-05-21 |
| 32427582 | This study addressed the clinical and immunopathological characteristics of severe COVID-19. […] Sixty-nine COVID-19 patients were classified into as severe and non-severe groups to analyze their clinical and laboratory characteristics. […] A panel of circulating cytokines could be used to predict disease deterioration and inform clinical interventions. | 2020-05-19 |
| 32427613 | This study is to summarize the clinical features, extracorporeal membrane oxygenation characteristics, and outcomes of patients with severe acute respiratory syndrome coronavirus 2 pneumonia received extracorporeal membrane oxygenation. […] Clinical records, laboratory results, ventilator parameters, and extracorporeal membrane oxygenation-related data were abstracted from the medical records. | 2020-05-19 |
| 32427637 | In addition, COVID-19 has many cardiovascular complications that affect the clinical course of patients. | 2020-05-19 |
| 32427773 | The COVID-19 pandemic has led to unprecedented stresses on modern medical systems, overwhelming the resource infrastructure in numerous countries while presenting a unique series of pathophysiologic clinical findings. […] All five patients appeared to have an improved respiratory status following tPA administration: one patient had an initial marked improvement that partially regressed after several hours, one patient had transient improvements that were not sustained, and three patients had sustained clinical improvements following tPA administration. | 2020-05-19 |
| 32427774 | Clinical trials of thrombolytic therapy would further serve to underscore the efficacy and utility of this therapy. | 2020-05-26 |
| 32427809 | These patients may have compromised physiological reserve to withstand the insult of surgical intervention before reaching clinical instability. | 2020-05-19 |
| 32427924 | In this study, we used artificial intelligence (AI) algorithms to integrate chest CT findings with clinical symptoms, exposure history and laboratory testing to rapidly diagnose patients who are positive for COVID-19. […] When CT scans and associated clinical history are available, the proposed AI system can help to rapidly diagnose COVID-19 patients. | 2020-05-19 |
| 32428080 | Given the characteristics of the COVID-19 pandemic and the limited tools for orienting interventions in surveillance, control, and clinical care, the current article aims to identify areas with greater vulnerability to severe cases of the disease in Rio de Janeiro, Brazil, a city characterized by huge social and spatial heterogeneity. | 2020-05-26 |
| 32428085 | We also make suggestions for immunocompromised patients’ support in this new emerging context of clinical dental practice. […] Cross infection control procedures for the clinical care of immunocompromised patients should follow the same guidelines that are being proposed for immunocompetent ones. […] However, during the active outbreak, people under immunosuppressive conditions should not receive elective procedures, even if they do not have symptoms or exposure history to COVID-19, and in case of emergence, care must be done in a separate airborne room. | 2020-05-26 |
| 32428112 | Multidisciplinary teams must be attentive to the signs and symptoms of COVID-19 so that decision-making is oriented and assertive for the management of the mother and newborn in both the hospital setting and at hospital discharge. | 2020-05-26 |
| 32428113 | Coronavirus disease (COVID-19) causes flu-like symptoms in most cases. | 2020-05-26 |
| 32428144 | A presentation can be divided into mild (fever, fatigue, cough, myalgia, and sputum) and severe (cyanosis, dyspnoea, tachypnea, chest pain, hypoxemia and need for clinical measurement) and has an estimated estimate of 2%.allows the detection of viral load in CRP-TR of patients with high clinical suspicion. | 2020-05-22 |
| 32428290 | This article presents a case of a pregnant woman from Wuhan infected with SARS-CoV-2, including her symptoms, pregnancy outcome, and treatment strategy. | 2020-05-23 |
| 32428291 | Most patients have mild influenza-like symptoms. | 2020-05-19 |
| 32428835 | In this review, the recent clinical findings about the relationship between coronaviruses and cardiovascular diseases and the underlying pathophysiological mechanisms are discussed. | 2020-05-25 |
| 32428864 | Further clinical trials in this regard can reveal a more definite conclusion against the COVID-19 disaster. | 2020-05-27 |
| 32428865 | We aimed to systematically search the literature to understand the pharmacology and clinical effects of remdesivir in patients with COVID-19. […] We systematically searched the PubMed, ClinicalTrial.Org and MedRxiv database up till May 5, 2020 using specific key words such as “Remdesivir” or ’GS-5734″ AND “COVID-19” or “SARS-CoV-2” and retrieved all the article published in English language, that have reported the pharmacology and the clinical outcomes of remdesivir in patients with COVID-19. | 2020-05-27 |
| 32428957 | For seven days now, the man has fever, dry cough und physical weakness and the wife has similar symptoms of a milder form. […] The clinical examination shows fine crackles over both lungs and a respiratory failure of the husband. | 2020-05-22 |
| 32428964 | Initially, nasopharyngeal testing was performed only on women with a positive screen (symptoms or exposure) but subsequently, testing was universally performed on all women admitted to labor and delivery. […] Eighty-one patients were tested because of a positive screen (symptoms [n = 60] or exposure only [n = 21]) and 75 patients were universally tested (all asymptomatic). […] Pregnant women who presented with COVID19-related symptoms and subsequently tested positive for COVID-19 have a higher rate of preterm delivery and need for respiratory support than asymptomatic pregnant women. […] It is important to be particularly rigorous in caring for COVID-19 infected pregnant women who present with symptoms. […] · Respiratory support is often needed for women who present with symptoms.. […] · Low rate of severe disease in women who present without symptoms.. | 2020-05-19 |
| 32428965 | Pregnant women have been historically excluded from clinical trials for nonobstetric conditions, even during prior epidemics. […] Among 621,370 trials in the World Health Organization International Clinical Trials Registry, 927 (0.15%) were COVID-19 related. | 2020-05-19 |
| 32429038 | We retrieved data on the clinical features and primary composite end point of COVID-19 patients from Medline and Embase which had been released from inception by the April 16, 2020. […] This will lead to better clinical management and inform the process of implementing more stringent preventative measures for this group of patients. | 2020-05-20 |
| 32429041 | Our early understanding of the clinical features of COVID-19 has been based on case series emerging from the first outbreak in Wuhan. […] Gastrointestinal symptoms were rarely reported as a key feature. […] We present a case report of a 74-year-old male who presented with symptoms of gastroenteritis and subsequently tested positive for COVID-19. | 2020-05-20 |
| 32429099 | Considering that the pandemic is a recent event, no large clinical trials have been possible and since coronavirus specific drug are not yet available, there is no strong consensus on how to treat the coronavirus disease 2019 (COVID-19) associated viral pneumonia. […] In this review, we recapitulate the roles of PLPs in coronavirus infections, report a list of PLP inhibitors and suggest possible therapeutic strategies for COVID-19 treatment, using both clinical and preclinical drugs. | 2020-05-21 |
| 32429101 | With the development of appropriate sample collection and processing methods and the use of adequate assays, saliva can provide useful clinical information about the disease and could be potentially included in guidelines for sample collection for the diagnosis, disease management, and control of Covid-19. | 2020-05-20 |
| 32429193 | The survey was aimed at highlighting the practical and emotional consequences of COVID-19 emergence on daily clinical practice. […] Furthermore, the psychological impact of COVID-19 was assessed by means of the Generalized Anxiety Disorder-7 test (GAD-7), that measures the presence and severity of anxiety symptoms. […] Almost 85% of the dentists reported being worried of contracting the infection during clinical activity. | 2020-05-22 |
| 32429235 | By addressing this, we aim to provide the foundations for a clinical perspective that reveals untapped potential, by highlighting how aberrant cell-specific changes in the expression of AMPK subunit isoforms could give rise, in part, to known associations between metabolic disease, such as obesity and type 2 diabetes, sleep-disordered breathing, pulmonary hypertension and acute respiratory distress syndrome. | 2020-05-21 |
| 32429249 | We searched for and summarised clinically relevant topics that could help making clinical decisions. […] This is a subjective analysis of literature concerning specific topics raised in our daily practice (e.g., clinical features of COVID-19 patients; ventilation of the critically ill COVID-19 patient; diagnostic of infection with SARS-CoV-2; stability of the virus; Covid-19 in specific patient populations, e.g., paediatrics, immunosuppressed patients, patients with hypertension, diabetes mellitus, kidney or liver disease; co-medication with non-steroidal anti-inflammatory drugs (NSAIDs); antiviral treatment) and we believe that these answers help colleagues in clinical decision-making. […] While respective guidelines on these topics will serve clinicians in clinical practice, regularly updating all guidelines concerning COVID-19 will be a necessary, although challenging task in the upcoming weeks and months. | 2020-05-20 |
| 32429580 | Remdesivir is a nucleotide prodrug that is currently undergoing extensive clinical trials for the treatment of COVID-19. | 2020-05-21 |
| 32429714 | The simulation training objective of this study was to enhance the neonatal, maternity, and anesthetics teams’ preparedness for the management of the emergency delivery of pregnant women with suspected or confirmed COVID-19 infection.Methods: Three clinical simulation training sessions were conducted in March 2020 at the University Hospital Plymouth, Plymouth, UK. […] The neonatal, maternity, and anesthetics clinical teams participated in these joint training sessions in the obstetric emergency theater.Results: Each session lasted for around an hour. […] The key changes were: first, floor plan adjustment, increase of the clinical area by converting some offices to clinical spaces, and standard operating procedures for transporting patients; second, enhancement of the efficiency of the communication and coordination between the clinical teams; third, availability of extra support for the staff in the Central Delivery Suite (CDS); and fourth, introduction of a neonatal care pathway to manage neonatal resuscitation in such an emergency.Conclusions: Collaboration and joint training between the different clinical teams involved in the care of suspected or confirmed COVID-19 patients was proven to be one of the most effective ways of improving performance. | 2020-05-20 |
| 32429769 | Introduction: During the current pandemic, measures for preventing SARS-CoV-2 virus exposure has severely impacted the delivery of outpatient clinical care to patients with a chronic neurological condition. | 2020-05-20 |
| 32429774 | This disease and its worldwide impact have sparked tremendous interest in the epidemiology, pathogenesis, and clinical consequences of COVID-19. […] COVID-19 patients present special challenges due to rapidly changing clinical status. | 2020-05-20 |
| 32429780 | Background: COVID-19 is a novel type of the coronavirus family with an incompletely described clinical course. […] While the clinical evidence was growing rapidly, this data may guide obstetricians and midwives to perceive what accurate information should be provided to the pregnant women. | 2020-05-20 |
| 32429786 | Although pregnant women are at an immunosuppressive state due to the physiological changes during pregnancy, most patients suffered from mild or moderate COVID-19 pneumonia with no pregnancy loss, proposing a similar pattern of the clinical characteristics of COVID-19 pneumonia to that of other adult populations. | 2020-05-20 |
| 32430088 | In this survey of hospital medical workers during the COVID-19 outbreak in China, we found that study participants experienced anxiety symptoms, especially those who had direct clinical contact with infected patients; as did those in the worst affected areas, including Hubei province; and those who were suspect cases. | 2020-05-29 |
| 32430154 | Development of hypolipidemia begins in patients with mild symptoms. | 2020-05-23 |
| 32430286 | Although in some recent studies a clinical improvement in COVID-19 patients has been observed, the clinical efficacy of CQ and HCQ in COVID-19 has yet to be proven with randomized controlled studies, many of which are currently ongoing, also considering pharmacokinetics, optimal dosing regimen, therapeutic level and duration of treatment and taking into account patients with different severity degrees of disease. […] Here we review what is currently known on the mechanisms of action of CQ and HCQ as anti-viral, anti-inflammatory and anti-thrombotic drugs and discuss the up-to-date experimental evidence on the potential mechanisms of action of CQ/HCQ in Sars-Cov2 infection and the current clinical knowledge on their efficacy in the treatment of COVID-19 patients. […] Given the role of iron in several human viral infections, we also propose a different insight into a number of CQ and HCQ pharmacological effects, suggesting a potential involvement of iron homeostasis in Sars-Cov-2 infection and COVID-19 clinical course. | 2020-05-31 |
| 32430428 | We compared clinical characteristics and SARS-CoV-2 RNA shedding between patients initiated with LPV/r treatment and those without. | 2020-05-20 |
| 32430617 | Also, it should be mentioned that in this manuscript, we discuss preliminary rationales; however, clinical trial evidence is needed to prove them. […] COVID-19 therapy must be based on expert clinical experience and published literature and guidelines from major health organizations. | 2020-05-23 |
| 32430621 | We report here the description of a multicenter retrospective-prospective observational study promoted by the Italian Society of Neurology (SIN), involving the Italian Neurological Departments, who will consecutively recruit patients with neurological symptoms and/or signs, occurred at the onset or as a complication of COVID-19. […] Outpatients with clinical signs of COVID and neurological manifestations will be also referred to participating neurologists from primary care physicians. […] A comprehensive data collection, in the form of electronic case report form (eCRF), will register all possible neurological manifestations involving central nervous systems, peripheral nerves, and muscles, together with clinical, laboratory (including cerebrospinal fluid, if available), imaging, neurological, neurophysiological, and neuropsychological data. | 2020-05-23 |
| 32430627 | Furthermore, patients with existing cardiovascular comorbidities, such as hypertension and coronary heart disease, have a worse clinical outcome following contraction of the viral illness. […] We will finally discuss the impact of clinically available CV drugs on the clinical course of COVID-19 patients. | 2020-05-23 |
| 32430637 | The coronavirus pandemic that started in December 2019 is mainly related to clinical pictures consistent with respiratory symptoms; nevertheless, reports about neurological complications have recently appeared in the medical literature. […] We describe a case of a 36-year-old coronavirus-positive patient that was admitted on emergency basis; his clinical presentation included neurological symptoms such as drowsiness and mild confusion. | 2020-05-23 |
| 32430651 | In clinical practice, angiotensin-converting enzyme inhibitors (ACE-Is) and angiotensin II receptor blockers (ARBs) are extensively used for the treatment of hypertension and other cardiovascular diseases. […] Yet, it has been claimed that both ARBs and ACE-Is could result potentially useful in the clinical course of SARS-CoV-2-infected patients. […] Older COVID-19-affected patients with cardiovascular comorbidities exhibit a more severe clinical course and a worse prognosis, with many of them being also treated with ARBs or ACE-Is. […] Despite the relevance of experimental animal studies, to comprehensively address the question of the potential hazards or benefits of ACE-Is and ARBs on the clinical course of COVID-19-affected patients treated by these anti-hypertensive drugs, we will need randomized human studies. […] Since ACE-Is and ARBs have different molecular targets, the clinical course of SARS-CoV-2 infection could be also different in patients treated by one or the other of these two drug classes. | 2020-05-23 |
| 32430840 | We employed a multivariate prediction model, based on up-to-date transmission and clinical parameters, to simulate outbreak trajectories in 16 countries, from diverse regions and economic categories. […] Efficient implementation of dynamic suppression interventions, therefore, confers a pragmatic option to: (1) prevent critical care overload and deaths, (2) gain time to develop preventive and clinical measures, and (3) reduce economic hardship globally. | 2020-05-27 |
| 32430957 | Eligibility criteria included laboratory-confirmed and/or clinically diagnosed COVID-19, patient being pregnant on admission and availability of clinical characteristics, including at least one maternal, perinatal or neonatal outcome. […] The most common symptoms at presentation were fever, cough, dyspnea/shortness of breath, fatigue and myalgia. | 2020-05-20 |
| 32430964 | Data on viral loads were scarce, but indicated that children may have lower levels than adults, partly because they often have fewer symptoms, and this should decrease the transmission risk. | 2020-05-20 |
| 32430996 | The main clinical manifestation of COVID-19 is the presence of respiratory symptoms, but some patients develop severe cardiovascular and renal complications. […] This review provides a basis for further research and development of clinical applications of curcumin for the treatment of newly emerged SARS-CoV-2. | 2020-05-20 |
| 32431118 | The disease is more severe in the older population, whereas in children lower infection rates and milder symptoms are more common. […] Severe symptoms in the pediatric population, although uncommon, have been reported mainly in infants younger than 1 year of age. | 2020-05-21 |
| 32431120 | Direct exposure to affected patients, the risk of contagion, a subjectively negative perception of one’s medical condition and being in isolation or quarantine, all constitute risk factors for mental symptoms such as depression, anxiety and post-trauma. | 2020-05-21 |
| 32431134 | Our reorganization has exploited the professional skills and clinical expertise of the RPTs. | 2020-05-22 |
| 32431217 | Data presented here predicted that these natural compounds may possess the potential to inhibit the functional activity of SARS-CoV-2 protease (an essential protein for virus survival), and hence (i) may connect to save time and cost required for designing/development, and initial screening for anti-COVID drugs, (ii) may offer some therapeutic value for the management of novel fatal coronavirus disease, (iii) warrants prioritized further validation in the laboratory and clinical tests. | 2020-05-20 |
| 32431755 | The low molecular weight fraction of commercial human serum albumin (LMWF5A), a novel biologic in development for osteoarthritis, demonstrates beneficial in vitro immunomodulatory effects complimentary to addressing inflammation, thus, we hypothesize that LMWF5A could improve the clinical outcomes of COVID-19 by attenuating hyperinflammation and the potential development of a cytokine storm. | 2020-05-23 |
| 32431992 | We present a case of a 41-year-old female, with no significant medical history and no recent history of exposure to sick contacts, presented to the emergency department (ED) with fever, severe shortness of breath, and flu-like symptoms with a positive COVID-19 test. | 2020-05-23 |
| 32432121 | Objective: To explore the clinical characteristics and dynamic follow-up changes of high resolution CT (HRCT) in 270 patients with Coronavirus Disease 2019 (COVID-19) pneumonia. Methods: Two hundred seventy COVID-19 pneumonia patients were retrospectively analyzed, including 146 males and 124 females, with median age of 51 (9,89). […] The clinical features, laboratory examination indexes and HRCT evolution findings of 270 COVID-19 pneumonia patients were analyzed. Results: 264 cases (95.74%) were positive at the first time nucleic acid test, 6 cases (2.22%) were negative, after multiple inspections, 270 cases (100%) were positive. […] During this study, a total of 173 patients (64.08%) were recovered after treatment. Conclusion: In some epidemiological backgrounds, CT imaging manifestations and evolutionary characteristics are of great significance for early warning of lung injury, assessment of disease severity, and assistance in clinical typing and post-treatment follow-up. | 2020-05-23 |
| 32432217 | To date the FDA has given emergency use authorization (EUA) to 48 COVID-19 in vitro diagnostic tests and 21 high complexity molecular-based laboratory developed tests, as well as implemented policies that give broad authority to clinical laboratories and commercial manufacturers in the development, distribution, and use of COVID-19 diagnostic tests. | 2020-05-26 |
| 32432389 | In this work, we review its major impacts on procedures and workflow of clinical physics tasks, and suggest alternate pathways to avoid major disruption or discontinuity of physics tasks in the context of small, medium, and large radiation oncology clinics. […] Three models of facilities characterized by the number of clinical physicists, daily patient throughput, and equipment were identified for this purpose. […] For identical objectives of continuity of clinical operations, with constraints such as social distancing and unavailability of staff due to system strain, however with the possibility of remote operations, the performance of these models was investigated. […] General clinical tasks requiring on-site personnel presence or otherwise were evaluated to determine the scalability of the three models at this point in the course of disease spread within their surroundings. […] The clinical physics tasks within three models could be divided into two categories. | 2020-05-20 |
| 32432527 | Preliminary clinical evidence from China and France showed significant virological and clinical benefit in HCQ-treated patients, while other studies, mostly including critically ill patients, did not show favorable results. | 2020-05-20 |
| 32432953 | I aim to share my thoughts as an unsettled 4th year medical student about to embark on my first set of clinical exams conducted in this format. […] The luxury of reference will not be afforded in all clinical settings thus leading to concerns regarding students skimming over essential learning points. | 2020-05-20 |
| 32432996 | However, there is limited data on the clinical characteristics, stroke mechanism, and outcomes of patients who have a stroke and COVID-19. […] We compared the clinical characteristics of stroke patients with a concurrent diagnosis of COVID-19 to stroke patients without COVID-19 (contemporary controls). | 2020-05-30 |
| 32433010 | In this review, we summarize demographic data, clinical characteristics, complications and outcomes and finally prevention and control of this serious pandemic. | 2020-05-20 |
| 32433161 | The patient was currently asymptomatic and without clinical evidence of active pneumonia. | 2020-05-23 |
| 32433162 | Meanwhile, the patient’s symptoms worsened, and a blood test later confirmed COVID-19 infection. | 2020-05-20 |
| 32433168 | A retrospective review of her clinical and laboratory data was strongly suggestive for diagnosis of COVID-19 infection. | 2020-05-20 |
| 32433216 | Clinical data were collected, and survival predictors were calculated. | 2020-05-20 |
| 32433217 | Specifically, focus is given to SARS-CoV-2 immunopathogenesis in the context of experimental therapies and pre-clinical evidence and their applicability in supporting efficacious clinical trial planning. | 2020-05-20 |
| 32433226 | HCoVs detected in children with acute gastroenteritis have included 229E, OC43, HKU1, NL63, and severe acute respiratory syndrome coronavirus, Middle East Respiratory Syndrome Coronavirus and severe acute respiratory syndrome coronavirus-2 have also been associated with gastrointestinal symptoms in children. […] Although digestive tract has been recognized as an infection route, it has not been possible to fully investigate the association between HCoVs infection and the gastrointestinal symptoms because of the limited number of pediatric cases. […] It has been necessary to pay more attention on gastrointestinal transmission to identify the infected children early and avoid the children without apparent or mild symptoms becoming the sources of infection. | 2020-05-20 |
| 32433251 | Plan adoption is, however, challenged by the need to coordinate with institutional efforts, a rapidly expanding number of patients, and the diversity of clinical and administrative functions in the department. | 2020-05-20 |
| 32433260 | In endemic regions, lower trauma volume may allow redeployment of orthopaedic surgeons and staff to other clinical arenas. | 2020-05-20 |
| 32433342 | Here we provide a review of COVID-19 on cardiovascular system to assist clinical cardiologists to better understand the disease and being capable of providing comprehensive medical support. | 2020-05-20 |
| 32433345 | To date, several direct anti-SARS-CoV-2 agents have demonstrated promising in vitro and clinical efficacy. | 2020-05-20 |
| 32433364 | These cases highlight an important opportunity to provide access to life-saving OUD treatment for vulnerable patients in the setting of a pandemic that mandates reduced face-to-face clinical interactions. | 2020-05-20 |
| 32433453 | To investigate the clinical evolution of coronavirus disease 2019 (COVID-19) in hospitalized pregnant women and potential factors associated with severe maternal outcomes. […] Clinical records, laboratory and radiologic examinations, and pregnancy outcomes were collected. | 2020-05-20 |
| 32433465 | We have previously engineered a synthetic DNA vaccine targeting the MERS coronavirus Spike (S) protein, the major surface antigen of coronaviruses, which is currently in clinical study. | 2020-05-26 |
| 32433778 | Several drugs with anti-inflammatory properties (tocilizumab, siltuximab, sarilumab, anakinra, among others) have been suggested as adjuncts to supportive care in the management of COVID-19, and several clinical trials are underway (NCT04315298, NCT04317092, NCT04306705). | 2020-05-20 |
| 32433799 | SARS-CoV-2, the virus responsible for the disease, is a single-stranded RNA virus which can cause a wide clinical spectrum of symptoms. | 2020-05-20 |
| 32434058 | The review explicitly covers the aspects like genome and pedigree of SARS-CoV-2; epidemiology, prognosis, pathogenesis, symptoms and diagnosis of COVID-19 in order to catalog the right information on transmission route, and influence of environmental factors on virus transmissions, for the robust understanding of right strategical steps for proper COVID-19 management. | 2020-05-29 |
| 32434093 | Lastly, according to the regression analysis, higher levels of intolerance to uncertainty, COVID-19-related worry, loneliness, as well as more severe depressive symptoms, were all predictive of insomnia. | 2020-05-27 |
| 32434108 | The high rate of mortality suggested that all patients on active anticancer treatment with flu-like symptoms have to be carefully screened for COVID-19 infection. | 2020-05-28 |
| 32434211 | Here we analyzed the clinical, molecular and immunological data from 326 confirmed cases of COVID-19 in Shanghai. […] Nevertheless, they exhibited similar virulence and clinical outcomes. | 2020-05-20 |
| 32434254 | Combined action for basic research, chemistry, pharmacognosy, virology, and clinical studies, but also supply chain, sustainable sourcing, and economic aspects have to be considered. | 2020-05-20 |
| 32434272 | However, clinical research is rapidly progressing, as shown by the hundreds of registered clinical trials on candidate drugs for COVID-19. […] All this makes data sharing and secondary analysis difficult.At last, small single centre studies and the use of drugs on a compassionate basis should be replaced by highly powered, multi-centre, multi-arm clinical trials, in orderto provide the required evidence of safety and efficacy of novel or repurposed candidate drugs. […] Hopefully, the efforts of clinical researchers in the fight against the SARS Cov-2 will result into the identification of effective treatments. […] To make this possible, clinical research should be oriented by guidelines for more harmonized high-quality studies and by a united commitment of the scientific community to share personal knowledge and data. […] Allergists and clinical immunologists should have a leading role in this unprecedent challenge. | 2020-05-20 |
| 32434277 | These patients do not normally present with clinical manifestations linked to COVID-19, and their PCR and serological tests are usually negative for specific IgM and IgG. | 2020-05-20 |
| 32434289 | A 66-years-old man presented to the hospital and his recent travel history, infective symptoms and CXR made him a possible COVID-19 suspect. | 2020-05-20 |
| 32434310 | The objectives of this study were to identify the clinical features and chest computed tomography (CT) findings of coronavirus disease 2019 (COVID-19) patients and to compare the characteristics of patients diagnosed in Wuhan and in other areas of China by integrating the findings reported in previous studies. […] Fever (84.8%; 95% CI, 78.5% to 90.1%) was identified as the most common clinical manifestation in all COVID-19 patients, and signs of respiratory infection were also frequently present in these patients. […] When comparing the clinical features according to the location of diagnosis, fever and dyspnea were less frequent in patients diagnosed outside of Wuhan (fever: 78.1%; 95% CI, 73.2% to 82.7%; dyspnea: 3.80%; 95% CI, 0.13% to 12.22%) than in patients diagnosed in Wuhan (fever: 91.7%; 95% CI, 88.0% to 94.8%; dyspnea: 21.1%; 95% CI, 13.2% to 30.3%). | 2020-05-21 |
| 32434314 | A group of Physical Medicine & Rehabilitation specialists from eleven different countries in Europe and North America have shared their clinical experience in dealing with COVID-19 survivors and how they have managed the re-organization of rehabilitation services. […] We analyze all these consequences and propose some practical treatment options, based on current evidence and clinical experience, as well as several suggestions for management of rehabilitation services and patients with suspected or confirmed infection by SARS-CoV-2. | 2020-05-21 |
| 32434337 | The most common symptoms include fever, dry cough, myalgia and shortness of breath. | 2020-05-26 |
| 32434339 | Diagnostic approaches to COVID-19 include clinical history, PCR tests for the presence of SARS-CoV-2 virus and detection of antibodies. […] We used a questionnaire to ascertain travel history and clinical signs of any respiratory tract infection. […] The enzyme-linked immunosorbent assay (ELISA) test system for SARS-CoV-2 from Euroimmun (Germany) was used to analyse immunoglobulin levels. 17 % of the tested cohort reported symptoms compatible with COVID-19 and 35.8 % reported history of international travel. | 2020-05-26 |
| 32434400 | The risk/benefit assessment and the main infection control policies in the clinical practices are also looked at. | 2020-05-21 |
| 32434402 | Currently all efforts are focused on the understanding of epidemiology, clinical features, mode of transmission, counteract the spread of the virus, and challenges of global health, while crucially significant mental health has been overlooked in this endeavor. […] Globally implementing preventive and controlling measures, and cultivating coping and resilience are challenging factors; modified lifestyle (lockdown curfew, self-isolation, social distancing and quarantine); conspiracy theories, misinformation and disinformation about the origin, scale, signs, symptoms, transmission, prevention and treatment; global socioeconomic crisis; travel restrictions; workplace hazard control; postponement and cancellation of religious, sports, cultural and entertainment events; panic buying and hoarding; incidents of racism, xenophobia, discrimination, stigma, psychological pressure of productivity, marginalization and violence; overwhelmed medical centers and health organizations, and general impact on education, politics, socioeconomic, culture, environment and climate - are some of the risk factors to aggravate further problems. | 2020-05-21 |
| 32434518 | The NLR had an area under receiver operating characteristic of 0.849 (95% confidence interval [CI], 0.707 to 0.991) in the derivation cohort and 0.867 (95% CI 0.747 to 0.944) in the validation cohort, the calibration curves fitted well, and the decision and clinical impact curves showed that the NLR had high standardized net benefit. | 2020-05-28 |
| 32434597 | Service provision is an ongoing challenge due to the increasing need for services given the increased mental health burden of COVID-19 but also the restrictions in place in clinical areas to achieve social distancing. | 2020-05-21 |
| 32434605 | We present the case of a lady in her thirties with a history of well controlled contamination OCD who presented acutely with a significant exacerbation of OCD symptoms precipitated by media reports of COVID-19. | 2020-05-21 |
| 32434615 | Management of the high rates of medical and psychiatric complications, including self-harm and suicide, associated with Anorexia Nervosa require regular clinical review. […] However, during the current pandemic, face to face clinical assessments carry the risk of infection and transmission in this vulnerable cohort already compromised by low weight and lowered immunity. | 2020-05-21 |
| 32434620 | Based on their clinical experience, the authors present mindfulness moments for clinicians (MMFC), a selection of short, simple and accessible mindfulness practices to promote resilience and compassion among clinicians working in this pandemic. | 2020-05-22 |
| 32434632 | Wuchang PFTH is the first one to put into clinical practice and the last one suspended in Wuhan. | 2020-05-26 |
| 32434633 | To study the clinical and epidemiological features of children with asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. […] The clinical data of 20 children who were diagnosed with asymptomatic SARS-CoV-2 infection from January 20 to March 4, 2020 were analyzed. […] All these children had no clinical manifestations and attended the hospital for an epidemiological history of SARS-CoV-2. | 2020-05-26 |
| 32434634 | To study the clinical features of coronavirus disease 2019 (COVID-19) in children aged <18 years. […] COVID-19 in children aged <18 years often occurs with family aggregation, with no specific clinical manifestation and laboratory examination results. […] Most of these children have mild symptoms and a good prognosis. | 2020-05-26 |
| 32434635 | Case 2 was a boy aged 13 years and 8 months and had no clinical symptoms; chest CT showed no abnormality, while the nucleic acid test of SARS-CoV-2 yielded a positive result. | 2020-05-26 |
| 32434708 | A questionnaire was used to collect demographic and clinical data. | 2020-05-29 |
| 32434788 | Clinical management is largely symptomatic, with organ support in intensive care for critically ill patients. […] Positive clinical and radiological outcomes have been reported. […] These early findings have led to an ongoing randomized controlled clinical trial in China and Italy. | 2020-05-29 |
| 32434790 | One important clinical question is how to manage patients who need anticancer therapy, including immune checkpoint inhibitors (ICIs) during these conditions. […] In particular, we consider the impact of ICI on COVID-19 severity, decisions surrounding continuing or interrupting therapy, diagnostic measures in patients with symptoms or manifestations potentially consistent with either COVID-19 or ICI toxicity, and resumption of therapy in infected patients. […] While more robust data are needed to guide clinicians on management of patients with cancer who may be affected by COVID-19, we hope this commentary provides useful insights for the clinical community. | 2020-05-29 |
| 32434798 | Based on a multi-institutional collaborative effort, we describe best practices when providing neurosurgical treatment for patients with covid-19 in order to optimize clinical care and minimize the exposure of patients and staff. | 2020-05-21 |
| 32434963 | Epidemic impact of severe acute respiratory syndrome (SARS) due to SARS CoV and Middle East respiratory syndrome (MERS) by MERS CoV has engraved their place in the scientific literature.2 In general, CoV is known to cause respiratory diseases in humans and accounts for one-third of common cold infections.3 The current outbreak by 2019 nCoV in the Chinese city of Wuhan began in December 2019, has infected nearly 102,188 with 3,491 deaths reported as of March 7, 2020, and has spread to nearly 92 countries.1,4 An assumed incubation period between 2 and 14 days, with flu-like symptoms, may progress into severe pneumonia or acute respiratory distress syndrome which may be the reason for mortality.5,6. | 2020-05-22 |
| 32435065 | In about 20% of patients, severe symptoms occur after a mean incubation period of 5 - 6 days; 5% of patients need intensive care therapy. | 2020-05-23 |
| 32435173 | This paper reports clinical recommendations and scientific studies to assist clinicians in this field. | 2020-05-23 |
| 32435268 | In view of the epidemiological and clinical characteristics of the COVID-19 outbreak, it is fundamental to stress that the behavior and hygiene rules adopted by children with cancer must be respected and implemented in order to continue to safeguard their health for the current pandemic. | 2020-05-23 |
| 32435272 | Cancer patients are a special group, the immunity of them will be suppressed because of various anti-tumor treatments, and the risk of infection will be greatly increased, so we will report clinical features of 9 cancer patients with SARS-CoV-2 infection. 5 (56%) patients were ordinary type, 3 (33%) were severe type, and 1 (11%) was critical type. […] From the clinical outcomes of these 8 patients, western combined therapy of traditional Chinese medicine was indeed an effective treatment method. […] D-dimmer rise, infection index rise, and chest CT(computed tomography) progression may be clinical warning indicators for severe patients, in our study, more 50% of patients had elevated levels of these indicators, but only 44% (including the dead) of patients had received treatment in the intensive care unit. 5 (56%) ordinary type patients had been discharged, while the 1 (11%) critical type patient died 3 days after admission. | 2020-05-23 |
| 32435867 | In addition, diabetes patients often suffer from comorbidities which further worsen clinical outcomes. | 2020-05-23 |
| 32435870 | Therefore, healthcare providers need to be familiar with the clinical presentation of infected patients and measures to quickly isolate them. | 2020-05-23 |
| 32435879 | The severity of symptoms was mild in all the patients, with little radiological involvement. […] Fever and upper respiratory symptoms were the most frequent findings. […] COVID-19 disease appears to have a similar clinical course in children with underlying chronic renal pathologies, even in immunosuppressed cases, as in healthy children of the same age; however, special attention must be paid to fluid management and drug dose adjustment. | 2020-05-23 |
| 32435882 | These results suggest that indomethacin could be considered as a promising candidate for the treatment of SARS-CoV-2 whose potential therapeutic effect need to be further assessed in a prospective clinical trial. | 2020-05-23 |
| 32435920 | The present review aims to present most of the pre-clinical and clinical evidence about lithium’s ability to inhibit DNA and RNA viruses, including Coronaviridae, as well as the possible pathways and mechanisms involved in such antiviral activity. […] Despite a broad number of in vitro studies, the rationale for the antiviral activity of lithium failed to translate into methodologically sound clinical studies demonstrating its antiviral efficacy. […] Lithium presents a clear antiviral activity demonstrated at preclinical level, but that remains to be confirmed in clinical settings. | 2020-05-23 |
| 32435925 | • CT findings of COVID-19 pneumonia may not be consistent with the clinical symptoms or the initial RT-PCR test results. | 2020-05-23 |
| 32436029 | Given the extent of the COVID-19 pandemic, and the large numbers of hospitalized patients requiring respiratory support, clinical use of inhaled nitric oxide may become an alternate rescue therapy before extracorporeal membrane oxygenation for the management of acute respiratory distress syndrome in patients with COVID-19. | 2020-05-23 |
| 32436101 | While the epidemic of Coronavirus disease 2019 (COVID-19) continues to spread globally, more and more evidences are collected about the presence of neurological manifestations and symptoms associated with it. […] Neurological manifestations, or NeuroCOVID, are part of the COVID-19 clinical picture, but questions remain regarding the frequency and severity of CNS symptoms, the mechanism of action underlying neurological symptoms, and the relationship of symptoms with the course and severity of COVID-19. […] Further clinical, epidemiological, and basic science research is urgently needed to understand and address neurological sequalae of COVID-19. | 2020-05-23 |
| 32436105 | The clinical spectrum ranges from asymptomatic infection to severe pneumonia, leading to intensive care unit admission. […] A retrospective case series of patients diagnosed with COVID-19 using reverse-transcriptase polymerase chain reaction (RT-PCR) on nasopharyngeal swabs, who developed clinical and neuroimaging evidence of acute stroke during SARS-CoV-2 infection. | 2020-05-23 |
| 32436355 | The pandemic of new severe acute respiratory syndrome (SARS) due to coronavirus (CoV) 2 (SARS-CoV-2) has stressed the importance of effective diagnostic and prognostic biomarkers of clinical worsening and mortality. […] Epidemiological data showing a differential impact of SARS-CoV-2 infection on women and men has suggested a potential role for testosterone (T) in determining gender-disparity in the SARS-CoV-2 clinical outcomes. […] To estimate the association between T level and SARS-CoV-2 clinical outcomes (defined as conditions requiring transfer to higher or lower intensity of care or death) in a cohort of patients admitted in the Respiratory Intensive Care Unit (RICU) MATERIALS AND METHODS: A consecutive series of 31 male patients affected by SARS-CoV-2 pneumonia and recovered in the Respiratory Intensive Care Unit (RICU) of the “Carlo Poma” Hospital in Mantua were analyzed. | 2020-05-21 |
| 32436441 | Based on observations described in our letter, we can draw the following conclusions: (1) anosmia must imperatively be added to the list of specific symptoms of COVID-19 infection, (2) anosmia can serve as a free and specific diagnostic tool for developing countries currently affected by the pandemic, (3) the mechanisms of COVID-19 anosmia seem not to directly involve nasal obstruction but rather seem to be related to damage the olfactory neuroepithelium. | 2020-05-21 |
| 32436445 | The use of chloroquine or hydroxychloroquine (HCQ), remdesivir, and tocilizumab are some of the other promising potential therapies; however, they are yet to be tested in randomized clinical trials (RCTs). | 2020-05-22 |
| 32436460 | Given the similarities of clinical features and pathogenesis between toxic epidermal necrolysis (TEN) and COVID-19, we hypothesize that the application of etanercept, an inhibitor of TNFα, could attenuate disease progression in severe group COVID-19 patients by suppressing systemic auto-inflammatory responses. The reviews of this paper are available via the supplemental material section. | 2020-05-22 |
| 32436581 | There is significant evidence that osteopathic manipulative medicine (OMM) can alleviate pulmonary symptoms and aid in quicker recoveries from various respiratory ailments. | 2020-05-21 |
| 32436617 | While it is unclear whether the patients on ISAs for skin conditions are more prone to develop COVID 19, and what impact the ISA may have on the clinical outcome if a patient does get infected, rationalizations based on the specific immune effects of each drug, and existing literature on incidence of various infections with each, are possible. […] In this review, we provide the readers with practically useful insights into these aspects, related to the conventional ISAs, and briefly mention the clinical outcome data available on related scenarios from other patient groups so far. | 2020-05-21 |
| 32436948 | We describe the clinical, laboratory, and imaging features of an 18-year-old woman who came to our attention for fever, neck pain radiated to the jaw, and palpitations occurring 15 days after a SARS-CoV-2-positive oropharyngeal swab. […] Neck pain and fever recovered within 2 days and the remaining symptoms within 1 week. […] We alert clinicians to additional and unreported clinical manifestations associated with COVID-19. | 2020-05-29 |
| 32436994 | We extracted and analyzed individual level data on baseline characteristics, laboratory findings, and clinical outcomes. […] Recent data indicate that severe COVID 19 causes cytokine release storm and is associated with worse clinical outcomes and IL-6 plays an important role. […] However, to our knowledge, there is no individual patient data systematic review performed to summarize baseline characteristics and clinical outcomes of COVID 19 patients who received tocilizumab. | 2020-05-21 |
| 32436996 | To study the relationship between clinical indexes and the severity of coronavirus disease 2019 (COVID-19), and to explore its role in predicting the severity of COVID-19. […] Clinical data of 443 patients with COVID-19 admitted to our hospital were retrospectively analyzed, which were divided into non-severe group (n=304) and severe group (n=139) according to their condition. […] Clinical indicators were compared between different groups. […] NLR, CRP and platelets can effectively assess the severity of COVID-19, among which NLR is the best predictor of severe COVID-19, and the combination of three clinical indicators can further predict severe COVID-19. | 2020-05-21 |
| 32437000 | This case demonstrates an atypical clinical presentation of COVID - 19 in an HIV infected patient without other co-morbidity. | 2020-05-21 |
| 32437004 | COVID-19 is highly contagious and has a variety of clinical manifestations, it can affect a number of other organs in addition to the lungs, and liver injury may occur. […] Clinical studies have found that liver injury in COVID-19 patients mainly manifests as abnormal liver biochemical indicators, but there have been no reports of liver failure caused by this disease. | 2020-05-21 |
| 32437014 | The results showed that ozone therapy may promote recovery of clinical condition and improvement of chest CT images, shorten the duration of viral shedding and length of hospital stay. | 2020-05-21 |
| 32437017 | We aimed to describe the epidemiological, clinical characteristics, and outcomes of all confirmed cases in Qinghai, a province at high altitude. | 2020-05-21 |
| 32437022 | No significant correlations were found between the presence and severity of chemosensitive disorders and the severity of the clinical course. […] On the contrary, there is a significant correlation between the duration of the olfactory and gustatory symptoms and the development of severe COVID-19. […] Contrary to recent reports, such objective testing refutes the proposal that the presence of olfactory and gustatory dysfunction may predict a milder course, but instead suggests that those with more severe disease neglect such symptoms in the setting of severe respiratory disease. | 2020-05-27 |
| 32437033 | Epidemiological and clinical data were collected. […] The most common symptoms were fatigue (72.9%), headache (60.0%), nasal obstruction (58.6%), and postnasal drip (48.6%). | 2020-05-21 |
| 32437077 | By examining the clinical data available in the public domain, the present work clarifies the clinical presentations in children with COVID-19 in China. […] SARS-CoV and SARS-CoV-2 shared similar clinical features. […] Similar to SARS, younger children had a less aggressive clinical course, compared with adolescents. […] While fewer symptoms were observed in children compared to adults, there is not yet sufficient evidence to conclude shorter hospital stay in children. | 2020-05-27 |
| 32437181 | Finally, clinical and research implications are discussed. | 2020-05-21 |
| 32437232 | In many clinical settings, this requires tools that can be broadly used to identify pathology and risks. | 2020-05-21 |
| 32437242 | The questions covered items on patients, healthcare workers, risk reduction measure and clinical trials. Results: A total of 12 centers involving 861 healthcare members joined the survey. […] The measures applied to patients and health workers partially converged in all the departments while major divergences were found in the clinical trials domain. | 2020-05-28 |
| 32437338 | The couple (the index cases) attended church-related events during March 6-8, and developed nonspecific respiratory symptoms and fever on March 10 (wife) and 11 (husband). […] Before his symptoms had developed, the husband attended a Bible study group on March 11. | 2020-05-22 |
| 32437432 | Of the 247 respondents, 205 (83.0%) knew the main clinical symptoms of COVID-19. | 2020-05-28 |
| 32437513 | In this review, we focus on the genomic, transmission and clinical characteristics of SARS-CoV-2, and comprehensively summarize the principles and related details of assays for SARS-CoV-2. […] SARS-CoV-2 has some unique gene sequences and specific transmission and clinical features that can inform the conduct of molecular and serological assays in many aspects, including the design of primers, the selection of specimens and testing strategies at different disease stages. | 2020-05-21 |
| 32437547 | To conduct surveillance for SARS-CoV-2 and describe symptoms of COVID-19 among residents and staff of an independent/assisted living community. […] SARS-CoV-2 real-time polymerase chain reaction was performed on nasopharyngeal swabs from residents and staff; a symptom questionnaire was completed assessing fever, cough, and other symptoms for the preceding 14 days. | 2020-05-21 |
| 32437575 | However, research on their infection risk and clinical characteristics is limited. […] To explore infection risk and clinical characteristics of HCWs with COVID-19 and to discuss possible prevention measures. […] Clinical, laboratory, and radiologic information was collected from electronic medical records. […] A total of 335 medical staff were randomly sampled to estimate the prevalence of subclinical infection among a high-risk, asymptomatic population. […] The prevalence of subclinical infection was 0.74% (1 of 135) among asymptomatic first-line HCWs and 1.0% (2 of 200) among non-first-line HCWs. […] The 5 most common symptoms were fever (67 [60.9%]), myalgia or fatigue (66 [60.0%]), cough (62 [56.4%]), sore throat (55 [50.0%]), and muscle ache (50 [45.5%]). | 2020-05-30 |
| 32437576 | To determine the prevalence and clinical presentation of COVID-19 among HCWs with self-reported fever or respiratory symptoms. […] Health care workers employed in the participating hospitals who experienced fever or respiratory symptoms were asked to voluntarily participate in a screening for infection with the severe acute respiratory syndrome coronavirus 2. […] Structured interviews were conducted to document symptoms for all HCWs with confirmed COVID-19. […] Of 9705 HCWs employed (1722 male [18%]), 1353 (14%) reported fever or respiratory symptoms and were tested. […] Only 3 (3%) of the HCWs identified through the screening had a history of travel to China or northern Italy, and 3 (3%) reported having been exposed to an inpatient with a known diagnosis of COVID-19 before the onset of symptoms. […] Within 2 weeks after the first Dutch case was detected, a substantial proportion of HCWs with self-reported fever or respiratory symptoms were infected with severe acute respiratory syndrome coronavirus 2, likely as a result of acquisition of the virus in the community during the early phase of local spread. […] The high prevalence of mild clinical presentations, frequently not including fever, suggests that the currently recommended case definition for suspected COVID-19 should be used less stringently. | 2020-05-30 |
| 32437586 | This hyper-responsiveness has been suggested to be the predominant aetiology for clinical deterioration and mortality in patients with this infection [2]. | 2020-05-21 |
| 32437596 | The universality and clinical implications of our observations require further research to define. | 2020-05-21 |
| 32437665 | The aim of the present study is to examine the impact of COVID-19 outbreak on the prevalence of depressive and anxiety symptoms and the corresponding risk factors among pregnant women across China. […] The internationally recommended EPDS was used to assess maternal depression and anxiety symptoms. […] Pregnant women assessed after the declaration of COVID-19 epidemic had significantly higher rates of depressive symptoms (26.0% vs 29.6%, P=0.02) than women assess pre-epidemic announcement. […] Pregnant women who were underweight pre-pregnancy, primiparous, < 35 years old, employed full-time, middle income, and had appropriate living space were at increased risk to develop depressive and anxiety symptoms during the outbreak. | 2020-05-23 |
| 32437679 | Outcomes were psychiatric signs or symptoms; symptom severity; diagnoses based on ICD-10, DSM-IV, or the Chinese Classification of Mental Disorders (third edition) or psychometric scales; quality of life; and employment. […] The systematic review revealed that during the acute illness, common symptoms among patients admitted to hospital for SARS or MERS included confusion (36 [27·9%; 95% CI 20·5-36·0] of 129 patients), depressed mood (42 [32·6%; 24·7-40·9] of 129), anxiety (46 [35·7%; 27·6-44·2] of 129), impaired memory (44 [34·1%; 26·2-42·5] of 129), and insomnia (54 [41·9%; 22·5-50·5] of 129). | 2020-05-24 |
| 32437696 | To prevent the rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and treat patients with mild symptoms, sports stadiums and convention centers were reconstructed into mobile hospitals. […] Whether a mobile cabin hospital can provide a safe treatment site for patients with mild COVID-19 symptoms remains unknown. […] We retrospectively reviewed the medical records of 421 patients with COVID-19 admitted to a mobile cabin hospital in Wuhan from February 9th to March 5th, 2020. […] Clinical data comprised patient age, sex, clinical presentation, chest imaging, nucleic acid testing, length of hospitalization, and outcomes. […] The outcome was recovery and hospital discharge in 86% of patients, while 14.0% developed severe symptoms and were transferred to a designated hospital. […] The most common presenting symptoms were fever (60.6%) and cough (52.0%), while 5.2% showed no obvious symptoms. […] Mobile cabin hospitals provide a safe treatment site for patients with mild COVID-19 symptoms, and provide an effective isolation area to prevent the spread of SARS-CoV-2. | 2020-05-23 |
| 32437706 | On day 11, his respiratory symptoms worsened. | 2020-05-31 |
| 32437740 | Immunologic dysfunction due to COVID-19 is closely related to clinical prognosis, and the inflammatory response of pregnant women may affect the directional differentiation and function of fetal immune cells. […] Along with collecting the clinical data from 51 newborns and their respective mothers, we also recorded the immunophenotypes and cytokine and immunoglobulin levels of the newborns. […] One (1.96%) infant with an extremely elevated IL-6 concentration developed necrotizing enterocolitis in the third week after birth, and the remaining 50 infants did not show abnormal symptoms through the end of the follow-up period. | 2020-05-23 |
| 32437770 | In this retrospective observational single-center study we analyzed the clinical course and outcomes of all MHD patients hospitalized with COVID-19 from March 12th to April 10th, 2020 as confirmed by real time polymerase chain reaction. […] Baseline features, clinical course, laboratory data, and different therapies were compared between survivors and non-survivors to identify risk factors associated with mortality. […] Clinical and radiological evolution during the first week of admission were predictive of mortality. […] Among the 36 patients, 18 had worsening of their clinical status, as defined by severe hypoxia with oxygen therapy requirements greater than 4 Liters/minute and radiological worsening. […] However, a longer time on hemodialysis (hazard ratio 1.008(95% confidence interval 1.001-1.015) per year), increased LDH levels (1.006(1.001-1.011), and lower lymphocyte count (0.996 (0.992-1.000) one week after clinical onset were all significantly associated with higher mortality risk. | 2020-05-23 |
| 32437797 | This virus associated symptoms and infectious respiratory illness is designated as coronavirus disease 19 (COVID-19). […] In the current review, we introduce a general overview about the human CoVs and the associated diseases, the origin, structure, replication and key clinical events that occur in the COVID-19 pathogenicity. | 2020-05-23 |
| 32437830 | Here we reported the clinical characteristics and liver pathological manifestations of COVID-19 patients with liver enzyme abnormality. […] We received 156 patients diagnosed of COVID-19 from two designated centers in China, and compared clinical features between patients with elevated aminotransferase or not. | 2020-05-23 |
| 32437877 | The abnormalities observed on chest computed tomography (CT) and the clinical presentation of COVID-19 patients are not always like those of typical acute respiratory distress syndrome (ARDS) and can change over time. | 2020-05-23 |
| 32437915 | A subgroup analysis revealed gender and occupational differences with female HCPs and nurses exhibiting higher rates of affective symptoms compared to male and medical staff respectively. | 2020-05-23 |
| 32437930 | We considered outbreak information where the first case registered in Marche with onset symptoms (26 February 2020) to the present date (20 April 2020). | 2020-05-31 |
| 32437932 | To report a clinical case of a patient with a compatible HRCT scan and two negative SARS-CoV-2 RNA upper respiratory tract specimens but with a confirmed viral infection by BAL (19 days after symptom onset). […] Revision of a patient’s clinical charts with COVID-19 admitted at INMI L. […] Spallanzani Hospital RESULTS: Two oropharyngeal swab tests of SARS-CoV-2 by qualitative real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay were performed at admission (17 days from symptoms onset) and a day apart and were found negative. […] BAL fluid collected 19 days after symptoms onset was positive for SARS-CoV-2. […] This case highlights importance of clinical suspicion of SARS-CoV-2 infection in diagnosis and infectivity assessment. | 2020-05-23 |
| 32437933 | Among these 31 patients, 22 presented symptoms after admission and were defined as asymptomatic patients in the incubation period (APIs); the other nine patients remained asymptomatic during hospitalization and were defined as asymptomatic patients (APs). | 2020-05-31 |
| 32437935 | To describe the clinical features of coronavirus disease 2019 (COVID-19). | 2020-05-31 |
| 32437936 | Cutaneous manifestation is a newly reported clinical manifestation of COVID-19 infection. […] The clinical description of cutaneous manifestation is still not fully described. | 2020-05-31 |
| 32437942 | Palliative care themes most frequently mentioned across documents were end-of-life visits, advance care planning documentation, and clinical decision-making towards the end of life (focusing on hospital transfers). | 2020-05-23 |
| 32437944 | Survival data were supplemented by descriptions of best- and worst-case clinical scenarios. | 2020-05-30 |
| 32438005 | Subsequently, a questionnaire with epidemiologic, radiologic, clinical, and serologic criteria will be applied to determine the risk of COVID-19 infection to define to which area they are going to be transferred according to the different risk zones in our facility. […] Despite not being a COVID-19 center, we consider all patients at the neurosurgical ward and staff members as asymptomatic carriers or infected in the preclinical period. | 2020-05-23 |
| 32438330 | This clinical protocol has not proven sufficient to save the lives of COVID-19 patients suffering from diabetes or having underlying liver diseases; hence there is utmost need to tackle this situation by other means such as Convalescent Plasma (CP) therapy. […] Hence, randomised clinical trials are recommended at the earliest to save the lives of infected individuals of COVID-19. | 2020-05-27 |
| 32438331 | Clinical evidence exists that patients with diabetes are at higher risk for Coronavirus disease 2019 (COVID-19). […] We investigated the physiological origins of this clinical observation linking diabetes with severity and adverse outcome of COVID-19. […] A deep network analysis has suggested clinical biomarkers predicting the higher risk: Hypertension, elevated serum Alanine aminotransferase, high Interleukin-6, and low Lymphocytes count. […] The revealed biomarkers can be applied directly in clinical practice. | 2020-05-27 |
| 32438333 | Studies published between December-2019 and March-2020 reporting demographic and clinical characteristics of COVID-19 cases were identified. | 2020-05-27 |
| 32438340 | Antithyroid drug (ATD)-induced neutropenia may favour the progression of COVID-19 and symptoms of infection may be confused with SARS-CoV-2 infection. | 2020-05-21 |
| 32438425 | Beginning March 22, 2020, all pregnant women from one large obstetrical practice in New York City were contacted regularly to inquire about symptoms of COVID-19 (fever, cough, shortness of breath, malaise, anosmia), or sick contacts. […] For this report, we included every patient with suspected COVID-19 infection, which was defined as at least two symptoms, or a positive COVID-19 nasopharyngeal polymerase chain reaction test. […] One woman had an unexplained fetal demise at 14 weeks’ gestation around the time of her COVID-19 symptoms. | 2020-05-21 |
| 32438446 | This analysis may be used to select potential candidates for further clinical testing, while deprioritising compounds unlikely to attain target concentrations for antiviral activity. […] Future studies should focus on EC90 values and discuss findings in the context of achievable exposures in humans, especially within target compartments such as the lung, in order to maximise the potential for success of proposed human clinical trials. | 2020-05-21 |
| 32438448 | Due to the COVID-19 pandemic, North Bristol NHS Trust (NBT) doctors were redeployed to unfamiliar clinical teams, where they would work at the level of a fully-registered Foundation doctor. […] As undergraduate clinical teaching fellows, we were re-purposed to rapidly produce a training programme to refresh the medical knowledge of doctors who were from a wide variety of non-medical specialities and grades. […] Building on our experience of facilitating medical students, wedevised medical ward-based scenarios in an informal Objective Structure Clinical Examination (OSCE) style to promote focused active learning and prompt further independent study. | 2020-05-21 |
| 32438450 | Immunomodulatory drugs are hypothesised to abrogate the dysfunctional immune response in hyperinflammatory COVID-19 and are currently being investigated in clinical trials. […] IL-1 blockage with anakinra has been shown to be safe and is associated with clinical improvement in patients with hyperinflammatory COVID-19 (Cavalli, et al 2020). | 2020-05-21 |
| 32438453 | The University of British Columbia (UBC) Faculty of Medicine suspended clinical rotations for medical students on March 14, 2020 due to the COVID-19 pandemic. | 2020-05-21 |
| 32438459 | Among these treatments, the off-label use of hydroxychloroquine (HCQ), a less toxic derivate of chloroquine, has become a common practice among clinicians, including pediatricians, despite lack of evidence of its clinical efficacy for this indication (especially for pediatric patients) at present time (2). | 2020-05-21 |
| 32438527 | The clinical situation is complex, with children presenting different clinical features compared to adults. | 2020-05-21 |
| 32438579 | This study aimed to investigate the clinical characteristics and outcomes of different types of family infections with COVID-19 and to share Taiwan’s experience. | 2020-05-22 |
| 32438622 | Different actions to cope with this situation are being developed, including confinement, different treatments to improve symptoms, and the creation of the first vaccines. | 2020-05-22 |
| 32438677 | IgG tests perform better compared to IgM ones and show better sensitivity when the samples were taken longer after the onset of symptoms. | 2020-05-22 |
| 32438687 | Extreme caution should be taken with diabetics with suspected symptoms of COVID-19 infection. | 2020-05-22 |
| 32438703 |
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2020-05-22 |
| 32438806 | The clinical performance of the OSN-qRT-PCR assay was evaluated using 181 clinical samples. […] Compared to the qRT-PCR kit, OSN-qRT-PCR assay revealed higher sensitivity and specificity hence better suited to clinical applications for the detection of SARS-CoV-2 in patients with low viral load. | 2020-05-22 |
| 32438868 | Quantitative real time PCR (RT-PCR) is widely used as the gold standard for clinical detection of SARS-CoV-2. […] We further explored the feasibility of ddPCR to detect SARS-CoV-2 nucleic acid from 77 clinical throat swabs, and compared with RT-PCR in terms of the diagnostic accuracy based on the results of follow-up survey. […] Overall, ddPCR shows superiority for clinical diagnosis of SARS-CoV-2 to reduce the false negative reports, which could be a powerful complement to the current standard RT-PCR. | 2020-05-22 |
| 32438876 | From 10 January 2020 to 10 February 2020, we continuously observed chest CT imaging of 14 patients with clinically suspected new coronavirus infection in the two weeks after onset of symptoms. | 2020-05-22 |
| 32438878 | The coronavirus disease 2019 (COVID-19) pandemic is having a major clinical as well as organisational impact on the national health-care system in Italy, particularly in high-volume hospitals which are usually active for many essential clinical needs, including inflammatory bowel disease (IBD). […] Here, we report major clinical and organisational challenges at a high-volume Italian IBD centre one month after the start of the Italian government’s restrictions due to the COVID-19 pandemic. […] Everyone attending the centre (e.g. physicians, nurses, administrative personnel and patients) were advised to respect the general recommended rules for hand hygiene and social distancing, to disclose if they had a fever or cough or flu-like symptoms and to wear a surgical mask and gloves. […] At the entrance of the therapy area, a control station was set up in order to double-check all patients with a clinical interview and conduct thermal scanning. […] At present, five patients have been found to be positive for SARS-CoV-2 infection but with minimal symptoms, 22 are in ‘quarantine’ for contact considered to be ‘at risk’ for the infection. […] Up to now, none of them has experienced significant symptoms. | 2020-05-22 |
| 32438895 | We recorded all stroke admissions, and the adequacy of acute care measures, including the number of thrombectomies, workflow metrics, angiographic results, and clinical outcomes. | 2020-05-30 |
| 32438941 | The Central Clinical Committee analyzed that these re-positive cases after the COVID-19 viral clearance are due to the limits of the test method; it is considered that the genetic material of the ‘dead virus’ remaining in the cured patients’ body is amplified during the test process. | 2020-05-22 |
| 32438945 | This study highlights the need at our clinical site for interventions to address the issues identified by staff. | 2020-05-22 |
| 32439197 | Acknowledging the comorbidities and potential organ injuries throughout the course of COVID-19 is therefore crucial in the clinical management of patients. | 2020-05-25 |
| 32439209 | Our study investigated the demographic, clinical, laboratory and imaging features of 63 patients with COVID-19 in Beijing. | 2020-05-25 |
| 32439237 | Telemedicine can help in the triage of patients to screen for symptoms of COVID-19 before their regular appointment. | 2020-05-25 |
| 32439306 | Although some measures have been supported by weak descriptive data, their effectiveness is still unclear pending well controlled clinical trials. | 2020-05-25 |
| 32439389 | To describe maternal disease and obstetrical outcomes associated with Covid-19 disease in pregnancy to rapidly inform clinical care. […] Symptoms resolved in a median of 24 days (interquartile range 13-37). | 2020-05-24 |
| 32439651 | Symptoms of possible COVID-19 infection (ie, fever, cough, and/or shortness of breath) were present in 20 of 27 (74%) patients. […] Correlation of chest CT results with epidemiologic history and clinical presentation, along with real-time reverse transcriptase polymerase chain reaction, is needed for confirmation. | 2020-05-29 |
| 32439716 | The prioritisation of high value cancer interventions must be embedded in the agenda for the pandemic response, ensuring that no inconsistency or discrepancy emerge in the health planning processes.The aim of this work is to organise health interventions for breast cancer management and research in a tiered framework (high, medium, low value), formulating a scheme of prioritisation per clinical cogency and intrinsic value or magnitude of benefit. […] The public health tools and schemes for priority setting in oncology have been used as models, aspiring to capture clinical urgency, value in healthcare, community goals and fairness, while respecting the principles of benevolence, non-maleficence, autonomy and justice.We discuss the priority health interventions across the cancer continuum, giving a perspective on the role and meaning to maintain some services (undeferrable) while temporarily abrogate some others (deferrable). […] Considerations for implementation and the essential link to pre-existing health services, especially primary healthcare, are addressed, outlining a framework for the development of effective and functional services, such as telemedicine.The discussion covers the theme of health systems strategising, and why oncology care, in particular breast cancer care, should be maintained in parallel to pandemic control measures, providing a pragmatic clinical model within the broader context of public healthcare schemes. | 2020-05-27 |
| 32439731 | Patients are presenting at emergency departments with symptoms of dyspnoea, dry cough and fever with varying severity. […] This is assisted through clinical assessment and various imaging and laboratory investigations, including chest X-ray, blood analysis and identification of viral infection with SARS-CoV-2. | 2020-05-27 |
| 32439821 | Patient data were obtained from medical records from the University Hospital “12 de Octubre,” Madrid, Spain. […] Further investigation is required to clarify the full clinical spectrum of neurologic symptoms and its optimal treatment. | 2020-05-22 |
| 32440387 | We review the differential diagnosis of acute airway obstruction after extubation, discuss techniques for achieving smooth extubation with avoidance of coughing and expectoration of secretions, and recommend, on the basis of this review, a clinical pathway for optimal management of upper airway obstruction including laryngospasm to avoid adverse outcomes. | 2020-05-25 |
| 32440660 | Results revealed that low-grade fever and cough were the principal symptoms in all patients. […] Available data showed that pregnant patients in late pregnancy had clinical manifestations similar to non-pregnant adults. | 2020-05-25 |
| 32440661 | Thus, it is necessary to clearly characterize clinical manifestations and management of COVID-19 infection in children to provide accurate information for healthcare workers. […] Accordingly, the present study was designed to review articles published on clinical manifestations and characteristics of children and infants with COVID-19. […] Clinical manifestation in children may be mild (72%), moderate (22%) or severe (6%), and the most common symptoms include dry cough (91%) and fever (96%). […] Infected children have relatively milder clinical symptoms compared to infected adults. | 2020-05-25 |
| 32440663 | Although the findings of some studies have been indicative of the direct relationship between the severity of clinical findings and imaging, reports have been published regarding inconsistency of clinical findings with imaging and laboratory evidence. […] This letter aimed to draw attention to the role of pulmonary thromboembolism as a potential and possible cause of clinical deterioration in covid-19 patients. | 2020-05-25 |
| 32440666 | The relationship of GGO score with age, sex, and symptoms at presentation was investigated. | 2020-05-25 |
| 32440692 | However, how SARS-CoV-2 causes neurological or GI symptoms is not clear. […] Many suggested intestinal and neural inflammations, caused by viral invasion, as the most likely reason for the GI and neurological symptoms; however, the patients with coronavirus disease 2019 (COVID-19) without neurological or GI symptoms indicate that this is not the case. […] The gut-brain axis could explain the reason for why some with COVID-19 do not have these symptoms. […] The temporal correlation between neurological and gastrointestinal symptoms suggests the lymph vessels around the GI tract, the vascular system, or the gut-brain axis (enteric nervous system) as the most likely entry route for SARS-CoV-2 to the brain. | 2020-05-22 |
| 32440724 | HCW were mostly physicians (74%), from high-prevalence regions (52%). 25% experienced typical symptoms during the last 14 days prior to survey completion, with only 45% of them being tested for COVID-19. | 2020-05-25 |
| 32440857 | The clinical characteristics and disease course in COVID-19 patients with pre-existing decompensated cirrhosis has not been described so far. | 2020-05-25 |
| 32440887 | The European Society for Pediatric and Neonatal Intensive Care (ESPNIC) launched the EPICENTRE (ESPNIC Covid pEdiatric Neonatal Registry) international, multicenter, and multidisciplinary initiative to study the epidemiology, clinical course, and outcomes of pediatric and neonatal SARS-CoV-2 infections. […] EPICENTRE is open to centers all over the world, and this will allow to provide a pragmatic picture of the epidemic, with a particular attention to pediatric and neonatal critical care issues.Conclusions: EPICENTRE will allow researchers to clarify the epidemiology, clinical presentation, and outcomes of pediatric and neonatal SARS-CoV-2 infection, refining its clinical management and hopefully providing new insights for clinicians.What is Known:• COVID19 is the new disease caused by SARS-CoV-2 infection and is spreading around the globe. | 2020-05-25 |
| 32440906 | Pulmonary complications are the most common clinical manifestations of coronavirus disease (COVID-19). […] From recent clinical observation, two phenotypes have emerged: a low elastance or L-type and a high elastance or H-type. […] Clinical presentation, pathophysiology, pulmonary mechanics, radiological and ultrasound findings of these two phenotypes are different. | 2020-05-25 |
| 32441229 | With little warning, clinical rotations were cancelled and medical students were sent home. […] While pre-clinical students transitioned to online curricula, clinical students were left without discreet educational goals. | 2020-05-26 |
| 32441243 | Both infections can manifest as digestive symptoms and merit screening when assessing patients with diarrhea during the coronavirus disease pandemic. | 2020-05-26 |
| 32441299 | Due to the lack of efficient therapeutic options and clinical trial limitations, the FDA approved drugs can be a good choice to handle Coronavirus disease (COVID-19). | 2020-05-22 |
| 32441330 | The review also sought to address the effectiveness of video calls on reducing symptoms of depression and improving quality of life. […] We included studies that included participants whether or not they were experiencing symptoms of loneliness or social isolation at baseline. […] We included studies in the review if they reported self-report measures of loneliness, social isolation, symptoms of depression or quality of life. […] The primary outcomes were loneliness and social isolation and the secondary outcomes were symptoms of depression and quality of life. […] We conducted fixed-effect meta-analyses for the primary outcome, loneliness, and the secondary outcome, symptoms of depression. […] Each study measured symptoms of depression using the Geriatric Depression Scale. […] The evidence suggests that video calls may have a small effect on symptoms of depression at one-year follow-up, though this finding is imprecise (MD -2.04, 95% CI -3.98 to -0.10; 1 study; 90 participants). […] The evidence regarding the effectiveness of video calls for outcomes of symptoms of depression was very uncertain. | 2020-05-27 |
| 32441332 | The aim of this study is to report our clinical experience in the management of pregnant women infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) during the first thirty days of the Coronavirus disease (COVID-19) pandemic. […] We reviewed clinical data from the first 60 pregnant women with COVID-19 whose care was managed at Puerta de Hierro University Hospital, Madrid, Spain from March 14th to April 14th , 2020. […] Demographic data, clinical findings, laboratory test results, imaging findings, treatment received, and outcomes were collected. […] The most common symptoms were fever and cough (75.5%, each) followed by dyspnea (37.8%). […] Most of the pregnant COVID-19 positive patients had a favorable clinical course. […] However, one-third of them developed pneumonia, of whom 5% presented a critical clinical status. | 2020-05-22 |
| 32441462 | There is an opportunity, but more importantly, an obligation for the global clinical and quantitative pharmacology community to come together and use our state-of-the-art tools and expertise to help society accelerate therapeutics to fight COVID-19. | 2020-05-22 |
| 32441548 | Social education about early recognition of symptoms of life-threatening cardiac conditions requiring appropriate care in a timely fashion may help to reduce this counter-productive phenomenon. | 2020-05-22 |
| 32441574 | Since its outbreak in Wuhan, Hubei Province China, 2019-coronavirus infected disease (COVID-19) had been widely spread all over the world, the control of which calls for a better understanding of its epidemiology and clinical characteristics. […] We included 12 confirmed cases of COVID-19 in First Affiliated Hospital of Jilin University from 23 January 2020 to 11 February 2020, which were retrospectively analyzed for epidemiological, demographic, clinical, laboratory, and radiological features. […] Clinical manifestations included fever (12/12), fatigue (10/12), cough (6/12), sore throat (4/12), headache (3/12), and diarrhea (2/12). | 2020-05-27 |
| 32441666 | In the study, we aimed to dissect the dynamic profile and clinical implications of hematological findings in hospitalized patients with COVID-19. | 2020-05-22 |
| 32441680 | The COVID-19 pandemic has required us to recognize a new normal and other additions to our general and clinical vocabulary. | 2020-05-27 |
| 32441744 | Online measures of how intense common household odors are perceived and symptoms of COVID-19 were collected from 2440 Swedes. […] Moreover, we found that there was a large difference in rated intensity between individuals with and without COVID-19 symptoms and number of symptoms was related to odor intensity ratings. […] Finally, we found that individuals progressing from reporting no symptoms to subsequently reporting COVID-19 symptoms demonstrated a large drop in olfactory performance. | 2020-05-22 |
| 32441753 | This report describes the clinical and virological characteristics of three children in a family cluster experiencing infection with SARS-CoV2. […] The children were only briefly symptomatic with predominant gastrointestinal symptoms. | 2020-05-22 |
| 32441764 | PARPi’s can effectively decrease IL-6, IL-1 and TNFα levels (key interleukins in SARS-CoV-2-induced cytokine storm) and can alleviate subsequent lung fibrosis, as demonstrated in murine experiments and clinical trials. | 2020-05-22 |
| 32441773 | The worldwide pandemic of the novel coronavirus disease 2019 (COVID-19) has raised many challenges and uncertainties regarding disease management and prognosis in immunocompromised patient populations. […] Previous reports suggest the possibility of a protective factor from standard antiretroviral treatment for HIV patients that could have significant clinical benefits for these patients when co-infected with SARS-CoV-2. […] HIV patients also generally present with atypical clinical presentation and have a less severe form of COVID-19 than the general population. | 2020-05-22 |
| 32441786 | In most cases, application of methylprednisolone in severe and critical viral pneumonia patients can quickly alleviate the symptoms of dyspnea and prevent disease progression. […] By comparing the clinical data we concluded that corticosteroids therapy can effectively release COVID-19 symptoms such as persistent fever and difficult breathing, improve oxygenation and prevent disease progression. | 2020-05-22 |
| 32441787 | Here, a patient with immune thrombocytopenic purpura in Huoshenshan Hospital (Wuhan, China) was reported, whose laboratory data, clinical treatment and hospital outcome was described in this study. | 2020-05-22 |
| 32441788 | Many critically ill patients with COVID-19 need specialty level palliative care to manage symptoms, conduct goals of care conversations, and facilitate medical decision making in ethically and emotionally charged situations. | 2020-05-22 |
| 32441935 | In this study, we established two RT-RAA assays for the S and orf1ab gene of SARS-CoV-2 using clinical specimens for validation. | 2020-05-22 |
| 32442030 | Although recent American College of Radiology recommendations assert that CT should not be used as a screening or diagnostic tool for patients with suspected COVID-19, radiologists should be familiar with the imaging appearance of this disease to identify its presence in patients undergoing CT for other reasons. MATERIALS AND METHODS. We retrospectively reviewed the CT findings and clinical symptoms of 30 pediatric patients with laboratory-confirmed COVID-19 who were seen at six centers in China from January 23, 2020, to February 8, 2020. | 2020-05-22 |
| 32442035 | Animal, mechanistic, laboratory, and preclinical evidence was gathered regarding aerosol dispersion of coronavirus. | 2020-05-27 |
| 32442082 | Whether these common symptoms in their patients are related to SARS-CoV-2 infection is not known. […] However, it is important to mention here that dramatic neurologic symptoms, i.e., depressed level of consciousness, seizure, and stroke, are common in the patients at the late stage of the disease, accounting for increased mortality rate in severely affected patients. […] Nevertheless, to objectively delve into the direct relation between the neurologic symptoms and COVID-19, medical comorbidities of patients should also be considered [2]. […] Further studies are needed because we are in the midst of an ongoing pandemic of COVID-19, and neurologists may be confronted with new-onset neurologic symptoms owing to COVID-19. […] Because SARS-CoV-2 causes severe respiratory symptoms in people aged 60 years and older, it has important implications for patients with Alzheimer’s disease (AD) [6]. […] However, the lockdown of patients with AD caused clinical studies to stop. which has severely affected dementia research. […] It is also known that movement restriction exacerbates AD symptoms [10]. […] Nonetheless, it is not sufficient for the continuation of clinical trials and experimental studies. | 2020-05-27 |
| 32442210 | The clinical features of COVID-19, such as fever, cough, shortness of breath, and fatigue, are similar to those of many acute respiratory infections. […] Here, we summarize recent progress in understanding the epidemiological, virological, and clinical characteristics of COVID-19 and discuss potential targets with existing drugs for the treatment of this emerging zoonotic disease. | 2020-05-28 |
| 32442256 | Infectivity of patients with Ct >24 and duration of symptoms >8 days may be low. […] This information can inform public health policy and guide clinical, infection control and occupational health decisions. | 2020-05-22 |
| 32442265 | Here, we aimed to further clarify the epidemiologic and clinical characteristics of asymptomatic SARS-CoV-2 infections. | 2020-05-22 |
| 32442285 | We aimed to assess the associations between prior use of RAAS inhibitors and clinical outcomes among Korean patients with coronavirus 2019 (COVID-19). […] Adjusted odds ratios (ORs) were used to compare the clinical outcomes between RAAS inhibitor users and nonusers. | 2020-05-22 |
| 32442287 | However, clinical benefits and mechanism of Tα1 supplement to COVID-19 are still unclear. […] We retrospectively reviewed the clinical outcomes of 76 severe cases with COVID-19 admitted into two hospitals in Wuhan from December 2019 to March 2020. | 2020-05-22 |
| 32442308 | To investigate clinical outcomes, distribution of quarantine locations, and the infection status of the contacts of COVID-19 patients after discharge. […] Demographics, baseline characteristics of 131 COVID-19 patients discharged from February 3 to 21, 2020 in Wuhan, China were collected and analyzed by reviewing the medical records retrospectively. […] Post-hospitalization data related to clinical outcomes, quarantine locations and close contact history were obtained by following up the patients every week up to 4 weeks. […] These symptoms constantly declined in 4 weeks post discharge. […] Although no contacted infection observed, appropriate self-quarantine and regular reexamination are necessary, particularly for those who have recurred symptoms. | 2020-05-22 |
| 32442333 | Although the risk is low, with the rapid spread of the COVID-19 and the appearance of alarmingly high infectivity and a high fatality rate, appropriate measures should be taken by health departments to ensure the safety of clinical blood. | 2020-05-22 |
| 32442437 | The clinical interest in proteasome inhibition has considerably increased after the FDA approval in 2003 of bortezomib for relapsed/refractory multiple myeloma, which is now used in the front-line setting. […] Thereafter, two other proteasome inhibitors (carfilzomib and ixazomib), designed to overcome resistance to bortezomib, have been approved for treatment-experienced patients, and a variety of novel inhibitors are currently under preclinical and clinical investigation not only for haematological malignancies but also for solid tumours. […] According to a multidisciplinary approach, spanning from chemistry, biochemistry, molecular biology to pharmacology, this review will summarize the most recent available literature regarding different aspects of proteasome biology, focusing on structure, function and regulation of proteasome in physiological and pathological processes, mostly cancer and neurodegenerative diseases, connecting biochemical features and clinical studies of proteasome targeting drugs. | 2020-05-25 |
| 32442528 | Data on the epidemiology, clinical course, and outcomes of critically ill patients with COVID-19 in this setting are needed. […] We prospectively identified adult patients (aged ≥18 years) admitted to both hospitals from March 2 to April 1, 2020, who were diagnosed with laboratory-confirmed COVID-19 and were critically ill with acute hypoxaemic respiratory failure, and collected clinical, biomarker, and treatment data. […] Secondary outcomes included frequency and duration of invasive mechanical ventilation, frequency of vasopressor use and renal replacement therapy, and time to in-hospital clinical deterioration following admission. […] The relation between clinical risk factors, biomarkers, and in-hospital mortality was modelled using Cox proportional hazards regression. […] National Institute of Allergy and Infectious Diseases and the National Center for Advancing Translational Sciences, National Institutes of Health, and the Columbia University Irving Institute for Clinical and Translational Research. | 2020-05-26 |
| 32442562 | Depleted symbionts and gut dysbiosis persisted even after clearance of SARS-CoV-2 (determined from throat swabs) and resolution of respiratory symptoms. | 2020-05-24 |
| 32442684 | In many places struck by the epidemic, clinical branches have prepared new guidelines for approaching the management of the disease in their area during the pandemic. | 2020-05-31 |
| 32442699 | Of the 18 patients, 50.0% (n=9) experienced de novo psoriasis, 27.8% (n=5) experienced exacerbation of psoriatic symptoms and 22.2% (n=4) had a relapse of psoriasis after HCQ administration. […] Monitoring for adverse effects of HCQ treatment is necessary, and clinical trials are essential in characterizing the safety profile of HCQ use in patients with a COVID-19 infection. | 2020-05-24 |
| 32442756 | In addition, 220 clinical and laboratory observations/records were also collected. […] Clinical indicators were associated with severe/critical symptoms were identified and a model for severe/critical symptom prediction was developed. […] Totally, 36 clinical indicators significantly associated with severe/critical symptom were identified. […] The clinical indicators are mainly thyroxine, immune related cells and products. […] Cox multivariate regression and survival analyses revealed that the model significantly discriminated the severe/critical cases and used the information of the selected clinical indicators. | 2020-05-29 |
| 32442932 | The aim of this study is to describe the clinical characteristics and course of illness of patients infected with Covid-19 that were hospitalized in a private clinical setting during March 2020. […] We recorded data about epidemiological characteristics, clinical signs and symptoms, in addition to comorbidities, laboratory and radiological studies were done. […] Larger population studies are required in order to confirm these clinical findings. | 2020-05-25 |
| 32443023 | Pediatric patients present a unique challenge as they may have minimal symptoms and yet transmit disease. | 2020-05-27 |
| 32443163 | Furthermore, the data obtained with high-dosed native interferon beta in life-threatening acute viral diseases as well as the results of clinical pilot studies with high-dosed recombinant interferon beta-1a are provided because they serve as the rationale for the proposed therapeutic regimen to be applied in acute viral infections. | 2020-05-22 |
| 32443442 | Here we evaluate clinical and imaging parameters for estimating the need of intensive care unit (ICU) treatment. […] We collected clinical, laboratory and imaging data from 65 patients with confirmed COVID-19 infection based on polymerase chain reaction (PCR) testing. | 2020-05-25 |
| 32443459 | We can conclude that: (1) rapid diagnostic tests for COVID-19 are necessary, but should be adequately sensitive and specific; (2) few studies have been carried out to date; (3) the studies included are characterized by low numbers and low sample power, and (4) in light of these results, the use of available tests is currently questionable for clinical purposes and cannot substitute other more reliable molecular tests, such as assays based on RT-PCR. | 2020-05-25 |
| 32443712 | A higher percentage of participants knew about “Clinical and pathogen characteristics of COVID-19”, compared to “Regulations and policies related to COVID-19”. | 2020-05-27 |
| 32443899 | We described features of hospitalized Covid-19 patients and identified predictors of clinical deterioration. […] We included patients consecutively admitted at Humanitas Research Hospital (Rozzano, Milan, Italy); retrospectively extracted demographic; clinical; laboratory and imaging findings at admission; used survival methods to identify factors associated with clinical deterioration (defined as intensive care unit (ICU) transfer or death), and developed a prognostic index. […] Clinical deterioration occurred in 70 patients (29.3%), including 41 (17.2%) ICU transfers and 36 (15.1%) deaths. […] The most common symptoms and signs at admission were cough (77.8%) and elevated respiratory rate (34.1%), while 66.5% of patients had at least one coexisting medical condition. […] Age; increased respiratory rate; abnormal blood gas parameters and imaging findings; coexisting coronary heart disease; leukocytosis; lymphocytopenia; and several laboratory parameters (elevated procalcitonin; interleukin-6; serum ferritin; C-reactive protein; aspartate aminotransferase; lactate dehydrogenase; creatinine; fibrinogen; troponin-I; and D-dimer) were significant predictors of clinical deterioration. | 2020-05-25 |
| 32444169 | The most common symptoms include cough, shortness of breath, and fever. | 2020-05-26 |
| 32444358 | Analyses of hospital length of stay and clinical outcomes included 1328 people admitted by 9 April 2020 (534 in northern California, 711 in southern California, and 83 in Washington). | 2020-05-28 |
| 32444366 | To describe outcomes of people admitted to hospital with coronavirus disease 2019 (covid-19) in the United States, and the clinical and laboratory characteristics associated with severity of illness. | 2020-05-28 |
| 32444382 | Furthermore, there have been extensive debates over antiviral candidates for their effectiveness and safety against severe acute respiratory syndrome CoV 2 (SARS-CoV-2), suggesting that rapid preclinical animal studies are required to identify potential antiviral candidates for human trials. […] While the lopinavir-ritonavir-, hydroxychloroquine sulfate-, or emtricitabine-tenofovir-treated group exhibited lower overall clinical scores than the phosphate-buffered saline (PBS)-treated control group, the virus titers in nasal washes, stool specimens, and respiratory tissues were similar between all three antiviral-candidate-treated groups and the PBS-treated control group. […] To further explore the effect of immune suppression on viral infection and clinical outcome, ferrets were treated with azathioprine, an immunosuppressive drug. […] Compared to the PBS-treated control group, azathioprine-immunosuppressed ferrets exhibited a longer period of clinical illness, higher virus titers in nasal turbinate, delayed virus clearance, and significantly lower serum neutralization (SN) antibody titers. […] Taken together, all antiviral drugs tested marginally reduced the overall clinical scores of infected ferrets but did not significantly affect in vivo virus titers. […] Despite the potential discrepancy of drug efficacies between animals and humans, these preclinical ferret data should be highly informative to future therapeutic treatment of COVID-19 patients.IMPORTANCE The SARS-CoV-2 pandemic continues to spread worldwide, with rapidly increasing numbers of mortalities, placing increasing strain on health care systems. […] While most of the drug treatments marginally reduced clinical symptoms, they did not reduce virus titers, with the exception of emtricitabine-tenofovir treatment, which led to diminished virus titers in nasal washes at 8 dpi. […] As several FDA-approved or repurposed drugs are being tested as antiviral candidates at clinics without sufficient information, rapid preclinical animal studies should proceed to identify therapeutic drug candidates with strong antiviral potential and high safety prior to a human efficacy trial. | 2020-05-27 |
| 32444393 | Our study aimed to investigate the clinical features of patients on maintenance hemodialysis. […] Demographic, clinical, laboratory, and radiologic characteristics and treatment and outcomes data were analyzed. […] In terms of common symptoms, there were differences between patients on hemodialysis and controls (fatigue [59% versus 83%], dry cough [49% versus 71%], and fever [47% versus 90%]). […] The main symptoms of coronavirus disease 2019 pneumonia, including fever and cough, were less common in patients on hemodialysis. | 2020-05-23 |
| 32444412 | Without human-assistance, the deep learning system automatically focused on abnormal areas that showed consistent characteristics with reported radiological findings.Deep learning provides a convenient tool for fast screening COVID-19 and finding potential high-risk patients, which may be helpful for medical resource optimisation and early prevention before patients show severe symptoms. | 2020-05-23 |
| 32444415 | The clinical features of rheumatic patients with coronavirus disease 2019 (COVID-19) have not been reported. […] This study aimed to describe the clinical features of COVID-19 in rheumatic patients and provide information for handling this situation in clinical practice. […] Deidentified data, including gender, age, laboratory and radiological results, symptoms, signs, and medication history, were collected from 2326 patients diagnosed with COVID-19, including 21 cases in combination with rheumatic disease, in Tongji Hospital between 13 January and 15 March 2020. […] Symptoms of fever, fatigue and diarrhoea were seen in 76%, 43% and 23% of patients, respectively. […] There were four rheumatic patients who experienced a flare of rheumatic disease during hospital stay, with symptoms of muscle aches, back pain, joint pain or rash. | 2020-05-23 |
| 32444460 | To characterise the clinical features of patients admitted to hospital with coronavirus disease 2019 (covid-19) in the United Kingdom during the growth phase of the first wave of this outbreak who were enrolled in the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) World Health Organization (WHO) Clinical Characterisation Protocol UK (CCP-UK) study, and to explore risk factors associated with mortality in hospital. […] A case report form developed by ISARIC and WHO was used to collect clinical data. […] The median duration of symptoms before admission was 4 days (interquartile range 1-8). | 2020-05-28 |
| 32444482 | In March 2020, we searched international and Chinese biomedical literature databases, clinical trial registries and prepublication sources for randomized controlled trials (RCTs) and nonrandomized studies comparing patients receiving and not receiving convalescent plasma. | 2020-05-23 |
| 32444493 | To report clinical and laboratory characteristics, as well as treatment and clinical outcomes of patients admitted for neurologic diseases with and without COVID-19. […] Demographic, clinical, treatment, and laboratory data were extracted from medical records and compared (FDR-corrected) to those of neurologic patients without COVID-19 admitted in the same period. | 2020-05-23 |
| 32444504 | Though it is hoped that the actual acute phase of COVID-19 infection will be short lived, it is vital that important clinical research is continued, given the long-term benefits of ongoing clinical research for patients with long-term conditions, including CVD. | 2020-05-23 |
| 32444569 | Rooming in of infected mothers and neonates, provided their good clinical conditions, is not contraindicated based on current knowledge. | 2020-05-23 |
| 32444743 | There is potential for a determined revision of the current activity-driven clinical approach, with the adoption of the minimally invasive oral care philosophy into routine practice and use of technology to remotely support our patients. […] These vital traits and bold clinical leadership, prepared to make timely choices and act fast, will underpin our successful transition towards the safe resumption of routine dental services. | 2020-05-27 |
| 32444797 | Biobanks can be either integrated into healthcare, where preservation of the biological material is a fork in clinical routine diagnostics and medical treatment processes or they can also host prospective cohorts or material related to clinical trials. | 2020-05-29 |
| 32444866 | The conduction of clinical trials should continue with appropriate adaptations to the current circumstances. […] For patients with positive PCR test for SARS-CoV-2, but with no symptoms for COVID-19, a 14-day quarantine should be considered if myeloma-related events allow the delay of treatment. | 2020-05-27 |
| 32444880 | An understanding of the risk factors and clinical outcomes of hospitalized patients with COVID-19 may provide guidance for management. […] Most (63%) had symptoms for 5 days or longer prior to admission. | 2020-05-23 |
| 32444942 | We describe the clinical course of 4 patients with Down syndrome during an outbreak of COVID-19. | 2020-05-26 |
| 32444993 | Urgent total hip arthroplasty in the setting of the COVID-19 pandemic is a complex decision-making process, involving clinical and epidemiological factors. | 2020-05-26 |
| 32445030 | All clinical studies, reviews, consensus and guidelines related to the above medications and COVID-19 were included. […] Lastly, prescription for vitamins B, C and D should continue as per usual clinical practice. | 2020-05-27 |
| 32445105 | Tier 2 consists of prospective functional and cognitive outcomes assessments with more detailed clinical, laboratory and radiographic data collection that would require informed consent. […] Study sites are eligible for participation if they provide clinical care to COVID-19 patients and are able to conduct patient-oriented research under approval of an internal or global ethics committee. […] Hospitalized pediatric and adult patients with SARS-CoV-2 and with acute neurological signs or symptoms are eligible to participate. | 2020-05-30 |
| 32445134 | A review of the literature revealed that the results of some studies suggest that ocular symptoms commonly appear in patients with severe COVID-19 pneumonia and that it is possible to isolate the virus from the conjunctival sac of these patients. | 2020-05-26 |
| 32445165 | Although COVID-19 lacks specific signs and symptoms, we believe internists should develop specific skills to recognize the disease, learning its ‘semeiotic’. […] In this review article, we summarize the key clinical features that may guide in differentiating a COVID-19 case, requiring specific testing, from upper respiratory and/or influenza-like illnesses of other aetiology. […] We consider two different clinical settings, where availability of the different diagnostic strategies differs widely: outpatient and inpatient. […] Our reasoning highlights how challenging a balanced approach to a patient with fever and flu-like symptoms can be. […] At present, clinical workup of COVID-19 remains a hard task to accomplish. […] However, knowledge of the natural history of the disease may aid the internist in putting common and unspecific symptoms into the correct clinical context. | 2020-05-27 |
| 32445195 | COVID-19 has created unprecedented challenges for amyotrophic lateral sclerosis (ALS) clinical care and research in the United States. […] Additionally, the pandemic has impacted ALS clinical trials by impairing the ability to obtain measurements for trial eligibility, to monitor safety and efficacy outcomes, and to dispense study drug since these also often rely on in-person visits. | 2020-05-23 |
| 32445249 | We review recent coronavirus-related epidemics and distinguish clinical and molecular features of CoV-2, the causative agent for COVID-19, and review the current status of vaccine trials. | 2020-05-23 |
| 32445484 | Several drugs are being repurposed into clinical trials in COVID-19 patients, ranging from drugs already well established in other diseases, such as chloroquine/hydroxychloroquine, lopinavir+ ritonavir, azithromycin and tocilizumab/sarilumab, to those such as remdesivir still in development for their initial indication (1). […] The opportunities for clinical pharmacology to contribute to the development of new treatments have already been described by others in Clinical Pharmacology & Therapeutics (2). | 2020-05-23 |
| 32445579 | Data of COVID-19 patients with clinical outcome in a designated hospital in Wuhan, China, were retrospectively collected and analyzed from Jan 30 to Feb 20, 2020. | 2020-05-23 |
| 32445580 | Epidemiological and clinical characteristics of patients with COVID-19 have been reported, but the relationships between laboratory features and viral load has not been comprehensively described. […] Laboratory data, demographic and clinical data were extracted from electronic medical records. | 2020-05-23 |
| 32445581 | Notably, the flux between clinical decisions based on best interests towards decisions explicitly based on resource considerations should be underpinned by an authoritative public policy decision to preserve legitimacy and lawfulness. | 2020-05-23 |
| 32445583 | All patients had an excellent outcome, and had minimal or no systemic symptoms. | 2020-05-23 |
| 32445710 | However, in settings where the outbreak continues to grow (eg, low-feasibility settings), so too will the burden of the number of contacts traced for active monitoring or quarantine, particularly uninfected contacts (who never develop symptoms). | 2020-05-27 |
| 32445839 | As the number of cases increased the demand for tests multiplied, leading the CDC to utilize the Emergency Utilization Authorization to allow clinical and commercial laboratories to develop tests to detect the presence of the virus. […] As SARS-CoV-2 virus arrived in the USA causing the COVID-19 illness, one of the most talked about issues in the management of the disease and the resulting pandemic has been clinical testing. […] In addition, multiple other tests were put in place under a separate authorization by a Presidential memorandum in early March allowing laboratories that carry Clinical Laboratory Improvement Amendment (CLIA) certification to put tests in place without an EUA from the FDA. | 2020-05-25 |
| 32445881 | Of 141 COVID-19 patients, baseline clinical and laboratory characteristics were similar between combined group and monotherapy group, that 30% of the patients leucocytes counts were below the normal range and 36.4% of the patients experienced lymphocytopenia. | 2020-05-26 |
| 32445935 | Overall, a total of 47/1051 (4,5%) cases were tested for COVID-19 by PCR in the same period, and 15 of them due to symptoms compatible with COVID-19. | 2020-05-25 |
| 32445956 | In China, interventional therapies with traditional Chinese medicine for COVID-19 have achieved significant clinical efficacies, but the underlying pharmacological mechanisms are still unclear. […] This article reviewed the etiology of COVID-19 and clinical efficacy. | 2020-05-31 |
| 32446167 | A Cox proportional hazards regression analysis was used to evaluate factors associated with clinical outcomes. | 2020-05-29 |
| 32446287 | Remdesivir (formerly GS-5734) is a nucleoside analogue pro-drug currently being evaluated in COVID-19 clinical trials. […] In pre-clinical models, remdesivir has demonstrated potent antiviral activity against diverse human and zoonotic β-coronaviruses, including SARS-CoV-2. […] In this article we critically review available data on remdesivir with an emphasis on biochemistry, pharmacology, pharmacokinetics and in vitro activity against coronaviruses as well as clinical experience and current progress in COVID-19 clinical trials. | 2020-05-23 |
| 32446305 | The symptoms of TB and COVID-19 can be similar, with for example cough and fever. […] There will be a confounding of symptoms and epidemiological data through co-infection, as happens already with TB-HIV, and this will require unpicking. | 2020-05-29 |
| 32446312 | The demographics, characteristics, laboratory parameters, treatments, and clinical outcome in these patients were retrospectively assessed. […] There were no significant differences between the two groups in gender, age, underlying diseases, clinical severity, and oxygen-support category at admission. | 2020-05-24 |
| 32446594 | Consistent with deaths in men, they are hospitalized more frequently than women: Significant gender differences in signs/symptoms can drive this pattern, already observed in other pathologies. | 2020-05-27 |
| 32446652 | COVID-19 could cause a wide range of symptoms ranging from self-limiting fever, sore throat, and cough to more severe symptoms that could lead to acute respiratory distress syndrome. | 2020-05-27 |
| 32446778 | There are still many unresolved questions regarding the pathogenesis of this disease and especially the reasons underlying the extremely different clinical course, ranging from asymptomatic forms to severe manifestations, including the Acute Respiratory Distress Syndrome (ARDS). […] SARS-CoV-2 showed phylogenetic similarities to both SARS-CoV and MERS-CoV viruses, and some of the clinical features are shared between COVID-19 and previously identified beta-coronavirus infections. […] Basic and clinical evidences obtained from previous SARS and MERS epidemics and available data from COVID-19 will be taken into account. | 2020-05-27 |
| 32446795 | Diabetes is an established risk associated with poor clinical outcomes, but the association of diabetes with COVID-19 has not been reported yet. […] The clinical features, treatment strategies and prognosis data were collected and analyzed. […] Common symptoms included fever (82.2%), dry cough (67.1%), polypnea (48.1%), and fatigue (38%). | 2020-05-26 |
| 32446813 | However, currently, drugs specifically approved for clinical use are not available, except for vaccines against COVID-19 that are being evaluated. […] Traditional Chinese medicine (TCM) is capable of performing syndrome differentiation and treatment according to the clinical manifestations of patients, and has a better ability of epidemic prevention and control. | 2020-05-27 |
| 32446978 | The clinical characteristics of all the COVID-19 patients hospitalised in the early days of the epidemic (21 February -19 March 2020) were recorded upon admission, and the time-dependent probability of death was evaluated using the Kaplan-Meier method (censored as of 20 April 2020). | 2020-05-27 |
| 32447060 | In 2020 both door-to-balloon and symptoms-to-PCI were longer and admission levels of hs-cTnI were higher. | 2020-05-27 |
| 32447102 | These data may be of interest to currently ongoing clinical trials of TCZ effects in Covid-19 patients and of optimal control of glycaemia in this patient subset. | 2020-05-30 |
| 32447193 | Clinical data were extracted from electronic medical records, and particularly data of all neurological symptoms were extracted from the imaging reports. | 2020-05-29 |
| 32447256 | We sought to evaluate the prevalence and etiology of all community acquired viral respiratory infections requiring hospitalization during an ongoing COVID-19 outbreak, with a focus on co-infection rates and clinical outcomes. […] Over a 10-week period, all admissions to our institution, the largest tertiary hospital in Singapore, were screened for respiratory symptoms, and COVID-19 as well as a panel of common respiratory viral pathogens were systematically tested for. […] Information was collated on clinical outcomes, including requirement for mechanical ventilation and in hospital mortality. […] One-fifth (19.3%, 736/3807) of hospitalized inpatients with respiratory symptoms had a PCR-proven viral respiratory infection; of which 58.5% (431/736) tested positive for SARS-CoV-2 and 42.2% (311/736) tested positive for other common respiratory viruses. | 2020-05-29 |
| 32447274 | Studies in subjects with multiple sclerosis (MS) have been heterogeneous in objectives and methodology, but generally support the concept that TM interventions produce clinical benefit, cost-effectiveness and user satisfaction. […] Incorporation of such services in routine clinical MS practice is expected to improve access to specialized care facilities for affected subjects. | 2020-05-24 |
| 32447328 | This has been proposed with a double aim: (1) an in-depth verification of the analytical and clinical performances presented by the manufacturer and (2) an economy of scale in terms of centralized validation for all the laboratories using the tests subject to evaluation. […] Methods A retrospective validation study was conducted including the serum of 125 patients in order to determine the analytical and clinical performances of the LIAISON®SARS-CoV-2 from DiaSorin® detecting anti-SARS-CoV-2 IgG and to compare its clinical performance with the enzyme-linked immunosorbent assay (ELISA) test from Euroimmun®, one of the first commercially available tests allowing the detection of anti-SARS-CoV-2 IgA and IgG. […] Results The performances of the LIAISON®SARS-CoV-2 satisfied all the acceptance criteria and provided “real world” analytical and clinical performances very close to the ones reported by the manufacturer in its insert kit. […] The analytical and clinical performances are excellent, and the automation of the test offers important rates, ideal for absorbing an extension of testing. | 2020-05-27 |
| 32447373 | In an effort to curb the spread of the epidemic, the government has requisitioned a variety of venues and plant buildings and built more than 20 cabin hospitals to receive patients with mild symptoms within 48 hours. | 2020-05-24 |
| 32447429 | The purpose of this review is to quantify the landscape of current clinical trials ongoing for therapies in the treatment of COVID-19. […] A systematic search of clinicaltrials.gov was undertaken on April 22, 2020, to identify all currently registered clinical trials investigating potential therapies for patients with COVID-19. […] Public interest in hydroxychloroquine and chloroquine was plotted against the cumulative number of active clinical trials evaluating antimalarials as potential COVID-19 therapies over time. […] There was a strong positive correlation (r = 0.76, p = 0.01) between the number of registered clinical trials and the public interest in the top ten proposed therapies. […] Moving forward, a concerted effort focused on implementing large, well-coordinated and carefully designed multi-armed clinical trials will help to ensure that the most promising therapeutic options are rigorously studied and clinically meaningful results produced. | 2020-05-27 |
| 32447629 | Concern about the appropriate role of nonsteroidal anti-inflammatory drugs (NSAIDs) in COVID-19 speculate that NSAIDs, in particular ibuprofen, may upregulate the entry point for the virus, the angiotensin-converting enzyme (ACE) 2 receptors and increase susceptibility to the virus or worsen symptoms in existing disease. | 2020-05-27 |
| 32447721 | In order to enhance scientific information interflow in the arena of liver diseases in Asia-Pacific region during this difficult time, Asian-Pacific Association for the Study of the Liver (APASL) has taken the initiative to form the APASL COVID-19 Taskforce to formulate a clinical practice guidance in Hepatology, liver-related oncology, transplantation and conduct of clinical trials. […] Based on scientific data and experiences, recommendations were made in the management of liver injury, liver transplantation, autoimmune diseases, chronic liver diseases, delivery of elective and emergency services and conduct of clinical trials. […] This is the first consensus clinical guidance synthesized by APASL for our hepatologist and their allied medical personal. | 2020-05-27 |
| 32447742 | The COVID-19 is mainly transmitted through respiratory droplets, with the most common symptoms being high fever, cough, myalgia, atypical symptoms included sputum production, headache, hemoptysis and diarrhea. […] However, the incubation period can range from 2 to 14 days without any symptoms. […] It is particularly true with gastrointestinal (GI) symptoms in which patients can still shed the virus even after pulmonary symptoms have resolved. […] Given the high percentage of COVID-19 patients that present with GI symptoms (e.g., nausea and diarrhea), screening patients for GI symptoms remain essential. […] Moreover, the epidemiology, clinical characteristics, diagnostic procedures, treatments and prevention of the gastrointestinal manifestations of COVID-19 remain to be elucidated. | 2020-05-27 |
| 32447746 | Such central nervous system (CNS) signs and symptoms linked to laboratory-confirmed SARS-CoV-2 infection is often life threatening. […] Health care providers currently evaluating patients with neurologic symptoms need consider COVID-19 in any differential diagnosis. […] These considerations will facilitate prompt testing, isolation and prevention of viral transmission speeding best clinical outcomes. | 2020-05-28 |
| 32447801 | We are here by suggesting that the clinical presentation of HZ at the time of the current pandemic even in patients giving mild or no suggestive history of upper respiratory symptoms should be considered as an alarming sign for a recent subclinical SARS CoV2 infection. | 2020-05-24 |
| 32447846 | Eventually, the clinical therapeutic effect may be improved, the national resources be economized on and the COVID-19 epidemic be conquered early. | 2020-05-27 |
| 32447904 | Objective: To estimate the infection rate of close contacts of COVID-19 cases, and to evaluate the risk of COVID-19 under different exposure conditions. Methods: A prospective study was used to conduct continuous quarantine medical observations of close contacts of people infected with COVID-19, collect epidemiological, clinical manifestations, and laboratory test data to estimate the infection rate of close contacts under different exposures. Results: The epidemiological curve of COVID-19 in Ningbo showed persistent human-to-human characteristics. | 2020-05-27 |
| 32447934 | Objective: To investigate the clinical and coagulation characteristics in patients with critical Coronavirus disease 2019 (COVID-19) and acro-ischemia. Methods: The retrospective study included 7 critical COVID-19 patients with acro-ischemia in an intensive care unit (ICU) in Wuhan, from Feb 4 to Feb 15, 2020. […] The clinical and laboratory data before and during the ICU stay were analyzed. Results: The median age of 7 patients was 59 years and 4 of them were men. […] Fever, cough, dyspnea and diarrhea were common clinical symptoms. […] Low molecular weight heparin (LMWH) was administrated in 6 patients, which reduced D-dimer and FDP rather than improved clinical symptoms. […] The timing and protocol of anticoagulation therapy are still under investigation based on more clinical data. 目的： 总结合并肢端缺血的新型冠状病毒肺炎（COVID-19）患者的临床和凝血功能特征。 | 2020-05-26 |
| 32448041 | We present several clinical studies related to the topic as well as a brief review of the potential pathophysiology of secondary infections that could present with Covid-19. | 2020-05-25 |
| 32448084 | In our recent study, we explored the feasibility of droplet digital PCR (ddPCR) for clinical SARS-CoV-2 nucleic acid detection compared with qRT-PCR using the same primer/probe sets issued by Chinese Center for Disease Control and Prevention (CDC) targeting viral ORF1ab or N gene, which showed that ddPCR could largely minimize the false negatives reports resulted by qRT-PCR [1]. […] Here, we further stringently compared the performance of qRT-PCR and ddPCR for 8 primer/probe sets with the same clinical samples and conditions. | 2020-05-25 |
| 32448085 | Overall, it is highlighted an important strategy, some key residues, and chemical groups which may be considered on clinical trials for COVID-19 outbreak. | 2020-05-25 |
| 32448333 | The knowledge of how surgeons dealing with emergency surgery have reacted to the epidemic in the real life can be useful while drafting clinical recommendations. | 2020-05-28 |
| 32448345 | The clinical manifestations of COVID-19 virus infection include asymptomatic infection, mild upper respiratory symptoms, severe viral pneumonia with respiratory failure, and even death. […] There are no antivirals of proven clinical efficacy in coronavirus infections. […] Adults (≥ 18 years) with laboratory-confirmed COVID-19 virus infection, severe pneumonia signs or symptoms, and radiologically confirmed severe pneumonia are randomly assigned in a 2:1 ratio to intravenously administered remdesivir or placebo for 10 days. […] The primary endpoint is time to clinical improvement (censored at day 28), defined as the time (in days) from randomization of study treatment (remdesivir or placebo) until a decline of two categories on a six-category ordinal scale of clinical status (1 = discharged; 6 = death) or live discharge from hospital. | 2020-05-27 |
| 32448405 | The most commonly presenting symptoms were dyspnoea, dry cough, and fever. | 2020-05-26 |
| 32448490 | This newly identified corona virus infection represents flu-like symptoms, but usually the first symptoms are fever and dry cough. […] In the present article, we made an attempt to review the behavior of the virus around the world, epidemiology, a pathway for influx into the host cells, clinical presentation, as well as the treatments currently in use and future approaches; nitazoxanide may be our dream drug. | 2020-05-27 |
| 32448757 | Consequently, diagnostic cardiovascular evaluations such as echocardiography are a crucial part of the disease management. | 2020-05-28 |
| 32448770 | In this open-label prospective study we describe clinical characteristics and outcome of 51 patients hospitalized with confirmed and severe COVID-19 pneumonia treated with tocilizumab intravenously. […] Clinical outcomes, oxygen support, laboratory data and adverse events were collected over a follow-up of 30 days. […] Over a median follow-up time of 34 days from tocilizumab, 34 patients (67%) showed an improvement in their clinical severity class; 31 were discharged; 17 (33%) showed a worsening of their clinical status, of these 14 died (27%). […] Tocilizumab exerts a rapidly beneficial effect on fever and inflammatory markers, although no significant impact on the clinical outcome can be inferred by our results. | 2020-05-30 |
| 32448805 | Before confirming a radiotherapy consult or a follow-up visit, telephone clinical and epidemiological screening is performed by nurses through a questionnaire regarding the presence of respiratory symptoms or eventual social contacts with COVID-19 positive people. | 2020-05-25 |
| 32448818 | These findings suggest that protease inhibitors of this type may inhibit coronavirus 229E replication in human airway epithelial cells at clinical concentrations. | 2020-05-29 |
| 32449021 | Among 175 household contacts not tested for SARS-CoV-2 infection, 67 (38.3%) had SARS-CoV-2 compatible symptoms, 39 (22.3%) had loss of smell or taste with 7 (4.0%) having loss of smell or taste in the absence of other symptoms. | 2020-05-28 |
| 32449022 | A questionnaire-based evaluation of symptoms was performed after 15 days in both groups. […] It appears that the number of patients treated with acetic acid (group 2) that experienced improvement in individual symptoms was double that of the other group of patients (group 1), although numbers are too small for robust statistical analysis. | 2020-05-28 |
| 32449034 | However, since SARS-CoV-2 RNA was detected in stool specimens much more attention has been paid to gastrointestinal symptoms such as loss of appetite, nausea, and diarrhea. | 2020-05-28 |
| 32449043 | In this study, the changes in clinical practice occurred in an orthopaedic center in Milan are described. | 2020-05-28 |
| 32449057 | Imaging and clinical reports have demonstrated central nervous system complications in patients’ with COVID-19, but there is a gap in our understanding of the neuropathology. […] The lesions described in this case provide insight into the potential parainfectious processes affecting COVID-19 patients, which may direct clinical management and ongoing research into the disease. […] The clinical course of the patient also illustrates that during prolonged hospitalizations neurological complications of COVID may develop, which are particularly difficult to evaluate and appreciate in the critically ill. | 2020-05-28 |
| 32449099 | Patients presenting to the ED between March 12 and March 28, 2020, with symptoms suspicious for COVID-19 and subsequent CXR and/or CT exam were selected. | 2020-05-28 |
| 32449100 | Testing remains at a premium, and criteria for testing remains reserved for those with lower respiratory infection symptoms and/or a known high-risk exposure. […] Patients were excluded if COVID-19 infection was suspected at the time of presentation, was the reason for imaging, or if any lower respiratory symptoms were present. […] At the time of presentation, no patients were febrile, and seven endorsed gastrointestinal symptoms. […] Five COVID-19 patients eventually developed respiratory symptoms and required intubation. […] Patients with imaging findings suspicious for COVID-19 warrant prompt reverse transcription polymerase chain reaction (RT-PCR) testing even in low clinical suspicion cases. […] The prevalence of disease in the population may be underestimated by the current paradigm of RT-PCR testing with the current clinical criteria of lower respiratory symptoms and exposure risk. | 2020-05-28 |
| 32449128 | We reviewed 1069 medical records of all cancer patients admitted at Oncology department between Feb 1 and April 7, 2020. […] We described Covid-19 cumulative incidence, treatment outcome, mortality, and associated risk factors. | 2020-05-28 |
| 32449178 | A multivariate analysis of covariance controlling for age, gestational age, household income, education and lifetime psychiatric disorders showed a large effect size (ES) in the difference between the two cohorts on psychiatric symptoms (Wilks’ λ=0.68, F6,1400 =108.50, p < 0.001, partial η2 = 0.32). […] According to post-hoc analyses of covariance, the COVID-19 women reported higher levels of depressive and anxiety symptoms (ES=0.57), dissociative symptoms (ES=0.22 and 0.25), symptoms of post-traumatic stress disorder (ES=0.19), negative affectivity (ES = 0.96) and less positive affectivity (ES=0.95) than the pre-COVID-19 cohort. […] Women from the COVID-19 cohort were more likely than pre-COVID-19 women to present clinically significant levels of depressive and anxiety symptoms [OR=1.94, χ2(1)=10.05, p=.002]. […] Multiple regression analyses indicated that COVID-19 pregnant women having a previous psychiatric diagnosis or low income would be more prone to elevated distress and psychiatric symptoms. […] Pregnant women assessed during the COVID-19 pandemic reported more distress and psychiatric symptoms than pregnant women assessed before the pandemic, mainly in the form of depression and anxiety symptoms. […] Given the harmful consequences of prenatal distress on mothers and offspring, the presently observed upsurge of symptoms in pregnant women calls for special means of clinical surveillance. | 2020-05-25 |
| 32449187 | Clinical nurses were conveniently recruited by an online link in three provinces out of Hubei, including Hunan (Central south), Chongqing (Southwest) and Xinjiang (Northwest) during 4-10 February 2020. | 2020-05-25 |
| 32449224 | Our aim is to report on the clinical characteristics, treatments and prognoses of COVID-19. […] The clinical characteristics, laboratory tests, treatment features and prognoses were summarized. […] Throughout a patient’s hospitalization, their treatment plan should be evaluated and adjusted according to their vital signs, clinical symptoms, laboratory tests and imaging changes. | 2020-05-25 |
| 32449235 | Although immunosuppressed patients may be more prone to SARS-CoV-2 infection with atypical presentation, long-term immunosuppression therapy may provide some sort of protection for severe clinical complications of COVID-19. | 2020-05-25 |
| 32449329 | Patients with coronavirus disease 2019 (COVID-19) can unknowingly spread the virus to several people during the early subclinical period. | 2020-05-27 |
| 32449523 | We also indicate that longer-term goals should include introducing truly innovative digital mental health practices, such as stepped-care models and simultaneously providing preventive and self-management services in addition to clinical services, into the health care system. | 2020-05-25 |
| 32449528 | The impact of Coronavirus disease 2019 (COVID-19) on clinical features of Parkinson’s disease (PD) has been poorly characterized so far. […] Changes in clinical features in the period January-April 2020 were compared with those of 36 PD control subjects, matched for sex, age, and disease-duration, using the clinical impression of severity index for PD, the Movement Disorders Society Unified PD Rating Scale parts II and IV, and the non-motor symptoms scale. […] Motor and nonmotor symptoms significantly worsened in the COVID-19 group, requiring therapy adjustment in one-third of cases. […] Clinical deterioration was explained by both infection-related mechanisms and impaired pharmacokinetics of dopaminergic therapy. | 2020-05-25 |
| 32449614 | The aim of this narrative review is to underline gender differences in epidemiology, etiopathogenesis, risk factors, clinical presentation, diagnosis, prognosis and mortality of patients infected with SARS-CoV-2. | 2020-05-26 |
| 32449663 | This article interprets 3 works of art in light of Roch’s story of illness and recovery and applies key insights of ethical, artistic, and clinical relevance to the COVID-19 pandemic. | 2020-05-27 |
| 32449757 | Caring for older patients with breast cancer presents unique clinical considerations due to preexisting and competing comorbidity, the potential for treatment-related toxicity, and the consequent impact on functional status. | 2020-05-25 |
| 32449766 | After segmenting and parsing documents, we conducted analysis of overrepresented words in patient symptoms. […] We then developed a word embedding-based convolutional neural network for predicting COVID-19 test results based on patients’ self-reported symptoms. […] As a result, screening algorithms were adapted to include these symptoms. […] Informatics tools such as NLP and AI methods can have significant clinical impacts when applied to data streams early in the development of clinical systems for outbreak response. | 2020-05-25 |
| 32449770 | Analysis found significantly greater odds of reporting symptoms of common mental health disorders (CMD), 2.49 (2.03-3.06), post-traumatic stress disorder (PTSD), 2.99 (2.11-4.24), poorer global health 2.09 (1.62-2.70) and emotional problems 1.69 (1.38-2.06) when individuals reported working with inadequate equipment. […] An individual’s perception of having inadequate equipment is significantly associated with symptoms of CMD, probable PTSD, poorer global health and increased reporting of emotional problems. | 2020-05-25 |
| 32449781 | This internet survey study investigated the prevalence, intensity and clinical characteristics of itch related to the use of face masks by the general public during the COVID-19 pandemic. | 2020-05-25 |
| 32449782 | To determine long-term clinical outcomes in survivors of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronavirus infections after hospitalization or intensive care unit admission. […] Original studies reporting clinical outcomes of adult SARS and MERS survivors 3 months after admission or 2 months after discharge were included. | 2020-05-25 |
| 32449791 | We analysed the impact of the pandemic on these patients’ neuropsychiatric symptoms and their quality of life after five weeks of lockdown in Spain. […] The Neuropsychiatric Inventory (NPI) and EuroQol-5D were used to evaluate the neuropsychiatric symptoms and quality of life of patients and caregivers. […] The most frequent neuropsychiatric symptoms affected were apathy (4.15 (3.78) vs 5.75 (4.02); p=0.002) and anxiety (3.95 (3.73) vs 5.30 (4.01); p=0.006) in MCI patients and apathy (2.35 (2.70) vs 3.75 (3.78); p=0.036), agitation (0.45 (1.14) vs 1.50 (2.66); p=0.029) and aberrant motor behaviour (1.25 (2.86) vs 2.00 (2.93); p=0.044) in AD patients. […] We have demonstrated the worsening of neuropsychiatric symptoms in patients with AD and MCI during 5 weeks of lockdown, with agitation, apathy and aberrant motor activity being the most affected symptoms. | 2020-05-25 |
| 32449792 | In this brief report we describe, our first single-centre experience from a 58-year-old Caucasian male patient with HIV who developed a severe SARS-CoV-2 infection, including clinical characteristics, treatment, and outcomes. | 2020-05-25 |
| 32449851 | Growing concerns for the safety of health care workers was raised when up to 80% of people with COVID-19 showed mild or no symptoms at all. | 2020-05-28 |
| 32449972 | In this study, we described the clinical characteristics of patients with coinfection. […] Common symptoms at the onset of illness included fever (six [100%] patients); five (83.3%) patients had a cough, shortness of breath, and fatigue. […] The other symptoms were myalgia (66.6%), gastrointestinal symptoms (33.3%-50%), and altered mental status (16.7%). | 2020-05-25 |
| 32450087 | We have therefore explored ACE2 receptor mRNA expression, and co-factors for Sars-CoV-2 infectivity (TMPRSS2 and furin) in bronchial brushes and biopsies from people with asthma and healthy controls, and looked for relationships between asthma severity, Th2- and IL-17 dependent gene signatures, and clinical demographics (age, sex). | 2020-05-28 |
| 32450165 | Coronaviruses are associated with comorbidities, along with the symptoms of it. | 2020-05-31 |
| 32450197 | Although most patients with COVID-19 manifest fever and respiratory tract symptoms, SARS-CoV-2 infection may also involve other organs/systems and present with extra-respiratory manifestations, including cardiac, gastrointestinal, hepatic, renal, neurological, olfactory, gustatory, ocular, cutaneous and haematological symptoms. […] Occasionally, these extra-respiratory symptoms/signs represent the initial presentation of SARS-CoV-2 infection, prior to fever or respiratory manifestations. […] Therefore, this comprehensive review of the extra-respiratory manifestations of COVID-19 is intended to help clinicians better understand the range of clinical presentations associated with SARS-CoV-2 infection, allowing the consideration of COVID-19 in differential diagnoses. […] Therefore, protective measures should be taken while managing the associated clinical specimens. | 2020-05-29 |
| 32450198 | While the World is finding expedited approvals for the development of vaccine, which is time dependent, being preventative and not possibly a cure, physicians and countries’ leaders are considering several concerted clinical trials suggesting that this age-old antimalarial drug, CQ/HCQ could be a potent therapeutic agent against COVID-19 infection. […] Given that there is no cure for COVID-19, the clinical testing of HCQ is urgently needed to ascertain its potency against the virus as this is the current available treatment option. […] There is still a need to find other innovative drug candidates as other possible candidate to go into clinical evaluation and testing. | 2020-05-28 |
| 32450265 | To assess perceptions of occupational risk and changes to clinical practice of ophthalmology trainees in the United States during the COVID-19 pandemic. […] Survey questions assessed policies guiding COVID-19 response, known or suspected exposure to SARS-CoV-2, changes in clinical duties and volume, and methods to reduce occupational risk including availability of personal protective equipment. […] Additional risk mitigation methods outside of PPE were: reduction in patient volume (n=62, 100%), limiting patient companions (n=59, 95.2%), use of a screening process (n=59, 95.2%), use of a slit lamp face shield (n=57, 91.9%), temperature screening of all persons entering clinical space (n=34, 54.84%), and placement of face mask on patients (n=33, 53.2%). […] Overall, 16.1% reported additional clinical duties within the scope of ophthalmology, and 3.2% reported being re-deployed to non-ophthalmology services. […] No respondents reported loss of employment or reduction in pay or benefits due to COVID-19. and Relevance: Suspected or confirmed clinical exposure to COVID-19 positive patients occurred in approximately one-fifth of trainee respondents. | 2020-05-29 |
| 32450312 | Here we surveyed program directors (PDs) to ascertain how they have altered the education and clinical care responsibilities of residents in response to the COVID-19 pandemic. | 2020-05-27 |
| 32450314 | The clinical data of all patients who underwent a neurosurgical intervention between March 23, 2020 and April 20, 2020 was obtained from a prospectively maintained database. […] Data of the control group was retrospectively collected from the medical records to compare the types of surgeries/interventions performed by the same neurosurgical service before the COVID-19 pandemic started. | 2020-05-27 |
| 32450344 | Our objective was to explore the effects of the administration of anti-platelet therapy on arterial oxygenation and clinical outcomes in patients with severe Covid-19 with hypercoagulability. […] Randomized clinical trials are urgently needed to confirm these results. | 2020-05-28 |
| 32450409 | The Depression Anxiety Stress Scale (DASS-21) was employed to assess symptoms of depression, anxiety and stress. | 2020-05-29 |
| 32450416 | There was a 25-3 fold increase in possible clinical cases of depression and an almost 8-fold increase in suicidal thoughts. | 2020-05-29 |
| 32450565 | Given the current shortage of personal protective equipment (PPE) and high infectivity of this virus, we acknowledge the utility of this tool in obtaining important clinical information while minimizing exposure and PPE consumption. | 2020-05-25 |
| 32450629 | A large number of severe cases lead to strong clinical pressure even treated actively. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | A large number of severe cases lead to strong clinical pressure even treated actively. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | A large number of severe cases lead to strong clinical pressure even treated actively. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | A large number of severe cases lead to strong clinical pressure even treated actively. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | A large number of severe cases lead to strong clinical pressure even treated actively. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | A large number of severe cases lead to strong clinical pressure even treated actively. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | A large number of severe cases lead to strong clinical pressure even treated actively. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | A large number of severe cases lead to strong clinical pressure even treated actively. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | A large number of severe cases lead to strong clinical pressure even treated actively. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | A large number of severe cases lead to strong clinical pressure even treated actively. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | A large number of severe cases lead to strong clinical pressure even treated actively. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | A large number of severe cases lead to strong clinical pressure even treated actively. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | A large number of severe cases lead to strong clinical pressure even treated actively. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | A large number of severe cases lead to strong clinical pressure even treated actively. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | A large number of severe cases lead to strong clinical pressure even treated actively. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | A large number of severe cases lead to strong clinical pressure even treated actively. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450631 | Objective: To analyze the clinical characteristics of 34 COVID-19 cases and to provide the basis for the prevention and control of the epidemic disease. […] The clinical data were collected. […] Excel was used to describe the relationship between clinical classification and age distribution, contact history and date of onset. […] The general information, clinical symptoms, blood test, virus nucleic acid test results, epidemiology, CT imaging, treatment and prognosis were analyzed. […] The main clinical symptoms were fever (27/34)and dry cough(26/34). […] Conclusions: The clinical characteristics of COVID-19 were similar to that of general viral pneumonia but with strong infectivity. | 2020-05-26 |
| 32450718 | At least 1 m of distance among people is recommended; however, some clinical practices cannot allow this distance. […] In this context, we believe that the careful safety assessment of clinical settings, like ophthalmologic ones, may have a remarkable impact on the fight against SARS-CoV-2 spread. | 2020-05-26 |
| 32450727 | The thin-section CT imaging findings and clinical and laboratory data of all the patients were evaluated. […] There were no significant differences between the 12 confirmed COVID-19 (SARS-Cov-2-positive) patients and 16 SARS-CoV-2-negative patients in epidemiology and most of the clinical features or laboratory data. | 2020-05-26 |
| 32450732 | With encouraging signs of pandemic containment nationwide, the promise of return to a full range of clinical practice is on the horizon. […] Since the COVID-19 pandemic is far from being over and the future may hold other highly communicable infectious threats that may require similar precautions, standard approaches to the clinical evaluation of common otolaryngology complaints will have to be modified. | 2020-05-26 |
| 32450752 | Efforts aimed at minimizing the spread of COVID-19 and “flattening the curve” may be affecting clinical care delivery for non-COVID-19 cases that include otolaryngologic and orbital conditions. […] We are witnessing changes in the manner that patients present, as well as modifications in clinical management strategies. […] An improved understanding of these phenomena and the contributing factors is essential for otolaryngologists to provide sound clinical care during this unprecedented pandemic. | 2020-05-26 |
| 32450761 | We performed a prospective analysis of a series of 27 consecutive patients with COVID-19 comparing both tracheostomy techniques, safety, and prognosis clinical markers. | 2020-05-26 |
| 32450906 | The present review summarizes latest clinical and epidemiological evidence for gender and sex differences in COVID-19 from Europe and China. | 2020-05-29 |
| 32451162 | Relevant publications reporting on the epidemiology of the pandemic, the diagnosis of the severe acute respiratory syndrome coronavirus 2 infection, and the clinical management of cancer and surgical patients, as well as studies concerning health care workers’ safety, were included. […] Clinicians should be aware of the importance of providing adequate care to patients with urgent and nondeferrable clinical issues, such as cancer. | 2020-05-29 |
| 32451271 | The basics of the virus, the clinical manifestations, and the possible mechanisms of cardiac complications in patients with COVID-19 are reviewed. | 2020-05-28 |
| 32451301 | Up to date, there are no reported deaths in pregnant women with Covid-19, while in the cases that have presented pneumonia because of Covid-19, the symptoms have been moderate and with a good prognosis in recovery. | 2020-05-29 |
| 32451351 | We agree with the authors that, despite conflicting clinical data to date, it is possible that HCQ may have a protective effect in the setting of COVID-19. […] More importantly, we agree that optimal HCQ dosage and timing is a critical underpinning for clinical trials. | 2020-05-26 |
| 32451353 | We would like to share ideas on the report on “Hydroxychloroquine in Patients with Rheumatic Disease Complicated by COVID-19: Clarifying Target Exposures and the Need for Clinical Trials [1].”Balevic noted that “well-designed clinical trials that include patients with rheumatic disease are urgently needed to characterize the efficacy, safety, and target exposures for hydroxychloroquine [1].” | 2020-05-26 |
| 32451358 | The results of this study suggest a proper PCS algorithm which combines the COVID-19 screening and protection measures could decrease the impact of the disease on the clinical outcomes of EVT for AIS patients to the lowest extent possible during the pandemic. | 2020-05-26 |
| 32451359 | Patient demographics, laboratory values, mechanical thrombectomy technique, and clinical and angiographic outcomes were reviewed. […] Patient clinical outcome was generally poor in this series of patients with COVID-19 large vessel occlusion. | 2020-05-26 |
| 32451362 | The purpose of this study was to explore the early clinical characteristics of COVID-19 patients with cardiovascular disease (CVD). […] Demographic and clinical factors and laboratory data were reviewed and collected to evaluate for significant associations. […] Symptoms of sputum production were more common in patients with CVD (p=0.026). | 2020-05-26 |
| 32451366 | The needed mitigation measures would significantly strain health system capacities, particularly for secondary and tertiary services, while many cases may pass undetected in primary care facilities due to weak diagnostic capacity and non-specific symptoms. | 2020-05-27 |
| 32451367 | We disaggregate the infected compartment into asymptomatic, mildly symptomatic and severely symptomatic to match observed clinical development of COVID-19. […] While most cases will be mild, we project in the absence of policies further containing the spread, that between 0.78% and 1.03%, 0.61% and 1.22%, and 0.60% and 0.84% of individuals in Ghana, Kenya and Senegal, respectively, may develop severe symptoms at the time of the peak of the epidemic. | 2020-05-27 |
| 32451563 | COVID-19 has a varied clinical presentation. […] This study identifies specific symptoms and comorbidities predicting severe COVID-19 and intensive care unit (ICU) admission. […] Random effects meta-analysis identified symptoms and comorbidities associated with severe COVID-19 or ICU admission. | 2020-05-28 |
| 32451564 | Loss of sense of smell and/or taste was reported by 26 of 63 COVID-19 patients (41%), whereas only 31% of the patients experiencing hyposmia had simultaneous symptoms of rhinitis. […] The data imply that a) COVID-19 can lead to hyposmia in a relevant number of patients, the incidence was approximately 30% in this cohort; b) in most cases, the olfactory disturbance was not associated with nasal obstruction, thus indicating a possible neurogenic origin; and c) the olfactory disorder largely resolved within 1-3 weeks after the onset of COVID-19 symptoms. | 2020-05-29 |
| 32451597 | These symptoms are associated with a cytokine storm syndrome. | 2020-05-28 |
| 32451729 | In our clinical practice, we do not use corticosteroids routinely; only low-to-moderate doses of corticosteroids were given to several severely ill patients prudently. | 2020-05-29 |
| 32451877 | Suspected or established COVID-19 patients may also have concomitant cardiovascular symptoms and require further imaging investigations. | 2020-05-29 |
| 32452036 | Participants self-reported onset of hand eczema and associated symptoms. […] A high prevalence of symptoms associated with acute hand dermatitis was found in 90.4% across all HCWs, whereas hand eczema itself was underreported (14.9%). | 2020-05-26 |
| 32452050 | In this review, we provide a comprehensive and up-to-date overview of the different types of Clinical and Para-clinical diagnostic methods and their practical features, which can help understand better the applications and capacities of various diagnostic approaches for COVID-19 infected cases. | 2020-05-26 |
| 32452195 | The diagnosis is based on the exposure history, clinical manifestation, laboratory test results, chest computed tomography (CT) findings and a positive reverse transcription-polymerase chain reaction (RT-PCR) result for coronavirus disease 2019 (COVID-19). | 2020-05-26 |
| 32452410 | Since SARS-CoV-2 spreads rapidly around the world, data have been needed on the natural fluctuation of viral load and clinical indicators associated with it. | 2020-05-29 |
| 32452545 | This can be done retrospectively, reporting on patients in the sample who have already been tested, or prospectively, performing the test on all available patients, regardless of whether they have symptoms. […] The retrospective method has a significant risk of confounding bias: due to the scarcity of COVID-19 tests8 , they are usually reserved for patients with COVID-19-related symptoms, who are obviously more likely to test positive. | 2020-05-26 |
| 32452644 | The coronavirus 2 (SARS-CoV-2) pandemic carries clinical, economic and social burdens that are currently being disclosed. […] Importantly, major concerns derive from the androgen-dependent tissue-expression of both TMPRSS2 and ACE2, suggesting a differential clinical course of the infection between genders. […] On these bases, gender-specific recommendations for the management of male patients affected by SARS-CoV-2 infection are warmly suggested, in order to improve the clinical course of the disease. | 2020-05-26 |
| 32452731 | OBJECTIVE. The purpose of this study was to compare clinical and chest CT findings in patients with influenza A (H1N1) pneumonia and coronavirus disease (COVID-19) pneumonia. MATERIALS AND METHODS. Thirty patients with diagnosed influenza A (H1N1) virus infection (group A) and 30 patients with diagnosed COVID-19 (group B) were retrospectively enrolled in the present study. […] The clinical characteristics and chest CT findings of the two groups were compared. RESULTS. Fever, cough, expectoration, and dyspnea were the main symptoms in both groups with viral pneumonia, with cough and expectoration more frequently found in group A. | 2020-05-26 |
| 32452739 | The objective of this investigation was to quantify airborne aerosol production under clinical and surgical conditions and examine efficacy of mask mitigation strategies. […] Prospective quantification of airborne aerosol generation during surgical and clinical simulation. […] Cadaver laboratory and clinical examination room. […] Aerosol sampling was additionally performed in simulated clinical and diagnostic settings. […] All clinical and surgical procedures were evaluated for propensity for significant airborne aerosol generation. […] In clinical simulations, nasal endoscopy (P < .05), speech (P < .01), and sneezing (P < .01) generated 1- to 10-μm airborne aerosols. […] During simulated clinical activity, airborne aerosol generation was seen during nasal endoscopy, speech, and sneezing. | 2020-05-28 |
| 32452804 | We developed a machine learning classifier to identify “sick posts,” in which users report their own or other people’s symptoms and diagnoses related to COVID-19. […] We found that reports of symptoms and diagnosis of COVID-19 significantly predicted daily case counts up to 14 days ahead of official statistics, whereas other COVID-19 posts did not have similar predictive power. | 2020-05-29 |
| 32452838 | Medical student volunteers, removed from their clinical duties, serve as virtual patient navigators, using social media to reach community members with the goals of improving awareness of precautions to take during the pandemic and of increasing access to needed medical care. | 2020-05-26 |
| 32452879 | COVID-19 survivors may suffer a range of clinical, functional and psychological impairments, resulting in disabilities. | 2020-05-26 |
| 32452954 | The commonest criteria to prioritize surgery were tumor biology (80%), time interval from neoadjuvant therapy (61%), risk of becoming unresectable (57%), and tumor-related symptoms (52%). | 2020-05-26 |
| 32452978 | A higher proportion of children had viral shedding in stools after 14 days of symptoms onset compared to respiratory samples (RR= 3.2, 95%CI 1.2 to 8.9, I2 = 51%). | 2020-05-26 |
| 32452979 | The patient presented with five days of fever, an erythematous maculopapular facial rash, and abdominal pain without respiratory symptoms. | 2020-05-26 |
| 32453053 | Although COVID-19 is principally defined by its respiratory symptoms, it is now clear that the virus can also affect the digestive system. […] In this review, we elaborate on the close relationship between COVID-19 and the digestive system, focusing on both the clinical findings and potential underlying mechanisms of COVID-19 gastrointestinal pathogenesis. | 2020-05-26 |
| 32453074 | Despite much emerging data about the epidemiological association between cardiovascular diseases and COVID-19, little is still known atrial fibrillation (AF) and its optimal management in this clinical contest. | 2020-05-26 |
| 32453196 | Clinical data of HCoV patients were compared with those infected by rhinovirus, respiratory syncytial virus and influenza. […] Clinical data in HCoV cases were similar to those associated with rhinovirus; however, patients with HCoV were younger. | 2020-05-26 |
| 32453451 | The clinical course among non-pregnant women has been described but data about potential risks for women and their fetus remain scarce. […] For COVID-19 infection, only 9 cases of maternal death have been reported as of April 22, 2020 and pregnant women seem to develop the same clinical presentation as the general population. | 2020-05-26 |
| 32453656 | We recognize that our recommendations may change over time based on clinical resources and the evolving nature of the COVID-19 pandemic. | 2020-05-26 |
| 32453695 | There is a growing evidence on the discrepancy between clinical symptoms and radiologic findings in many patients. […] This case report gives details about a patient with only mild symptoms but relatively severe radiological findings. | 2020-05-28 |
| 32453702 | The results were interpreted with respect to the clinical condition of the patients. […] Interventional clinical trials may be helpful in defining the appropriate drug(s), for this purpose, the algorithms of administration, and the optimal duration of therapy. […] At present, the authorization of a clinical trial that attempts to answer these questions is in progress. | 2020-05-28 |
| 32453889 | We have measured Hb O2 affinity curves from severely ill COVID-19 patients and, in comparison to age- and sex-matched controls, find no evidence for a shift in O2 affinity that would support any change in clinical management. | 2020-05-26 |
| 32454025 | The COVID-19 and Cancer Consortium (CCC19) aims to collect and analyze observational data at scale to inform clinical practice in real-time. | 2020-05-28 |
| 32454092 | A significant amount of clinical and research interest in thrombosis is focused on large vessels (e.g., stroke, myocardial infarction, deep venous thrombosis, etc.); however, thrombosis is often present in the microcirculation in a variety of significant human diseases, such as disseminated intravascular coagulation, thrombotic microangiopathy, sickle cell disease, and others. […] In this review, we discuss endogenous regulatory mechanisms that prevent thrombosis in the microcirculation, experimental approaches to induce microvascular thrombi, and clinical conditions associated with microvascular thrombosis. | 2020-05-29 |
| 32454103 | Clinical symptoms and laboratory findings of the human coronavirus disease COVID-19, caused by the novel coronavirus SARS CoV-2, indicate cytokine involvement. | 2020-05-31 |
| 32454157 | Several clinical trials are on-going including testing Remdesivir (anti-viral), Chloroquine and Hydroxychloroquine derivatives (anti-malarial drugs) etc. | 2020-05-31 |
| 32454186 | An analysis of the utilization of palliative care in accordance with patient comorbidities and other characteristics was performed while considering clinical outcomes. | 2020-05-29 |
| 32454187 | We summarised all registered clinical trials examining treatment and prevention options for COVID-19. […] Clinicaltrials.gov, the Chinese Clinical Trial Registry and the European Union Clinical Trials Register were systematically searched. […] Registered clinical trials examining treatment and/or prevention options for COVID-19 were included. […] Numerous clinical trials have been registered since the onset of the COVID-19 pandemic. | 2020-05-29 |
| 32454233 | The majority of vascular surgeons are reusing PPE (71.4%) and N95 masks (86.4%), and 21% of vascular surgeons feel that they do not have adequate PPE to perform clinical their duties. | 2020-05-28 |
| 32454253 | There is a lack of evidence-based literature providing clinical and organizational guidelines for the management of a general surgery department. | 2020-05-29 |
| 32454512 | Our results suggest CB6 deserves further clinical translation. | 2020-05-26 |
| 32454513 | The antibodies identified here may be candidates for the development of SARS-CoV-2 clinical interventions. | 2020-05-26 |
| 32454807 | Of the 222 newborns, 13 were reported as positive for SARS-CoV-2; most of the studies reported no or mild symptoms and no adverse perinatal outcomes. […] Two papers among those from newborns who tested positive reported moderate or severe clinical characteristics. | 2020-05-29 |
| 32454808 | All patients had fever and/or symptoms of acute respiratory illness and chest computed tomography images indicative of COVID-19 pneumonia. | 2020-05-29 |
| 32454888 | At present, COVID-19 has no specific therapeutic drugs, and the main clinical treatment is symptomatic treatment and control of complications. | 2020-05-29 |
| 32454891 | An attempt has been made to translate these sets of guidance into clinical provisions via the recently established Homerton Covid Psychological Support (HCPS) pathway delivered by Talk Changes (Hackney & City IAPT). | 2020-05-29 |
| 32454981 | This commentary aims to elaborate challenges in the regulatory approaches for accessing and investigating COVID-19 potential therapies either with off-label use, compassionate use, emergency use or for clinical trials. […] Since no therapies have been formally approved and completely effective and safe to date, the best clinical choice is acquired only after consistent and fair communication and collaboration between licensed clinicians, researchers, regulatory authorities, manufacturers and patients. | 2020-05-28 |
| 32455089 | The SARS-CoV-2, a novel virus has shown an association with central nervous system (CNS) symptoms. […] Initial retrospective studies emerging from China and France, as well as case reports from different parts of the world revealed a spectrum of neurological symptoms ranging from a simple headache to more serious encephalitis and dysexecutive syndromes. | 2020-05-29 |
| 32455090 | Imaging and clinical presentation was consistent with COVID-19 and lab tests for the pathogen were ordered. […] Once negative results were obtained, the PUI protocol was abandoned despite ongoing symptoms. […] Subsequently, dermatological symptoms developed and transfer to our burn center was initiated. […] Given the lack of resolve of respiratory symptoms and concern for the burn patient population, the patient was placed in PUI protocol and an internal COVID-19 was ordered. | 2020-05-29 |
| 32455147 | Clinical findings indicated that a fraction of coronavirus disease 2019 (COVID-19) patients diagnosed as mild early may progress to severe cases. […] The present study aimed to describe the clinical characteristics of these patients, analyze related factors, and explore predictive markers of the disease aggravation. […] Clinical and laboratory data of nonsevere adult COVID-19 patients in Changsha, China, were collected and analyzed on admission. | 2020-05-26 |
| 32455168 | Allocation of these resources to those most likely to benefit can be supported by clinical prediction models. | 2020-05-29 |
| 32455442 | Recommendations of the Thoracic Imaging Section of the German Radiological Society for clinical application of chest imaging and structured CT reporting in the COVID-19 pandemic. […] Recommendations of the Thoracic Imaging Section of the German Radiological Society for clinical application of chest imaging and structured CT reporting in the COVID-19 pandemic. | 2020-05-26 |
| 32455475 | Patients with preexisting cardio-vascular conditions are at higher risk of developing severe symptoms and worse outcome. | 2020-05-26 |
| 32455515 | Objective: To analyse the clinical history, laboratory tests and pathological data of a patient who suffered from novel coronavirus pneumonia(COVID-19) and provide reference for the clinical treatment of similar cases. Methods: Data of clinical manifestation, laboratory examination, bronchoscopy, echocardiography and cardiopulmonary pathological results were retrospectively reviewed in a case of COVID-19 with rapid exacerbation from mild to critical condition. Results: This patient hospitalized at day 9 post 2019 novel coronavirus(2019-nCoV) infection, experienced progressive deterioration from mild to severe at day 11, severe to critical at day 18 and underwent extracorporeal membrane oxygenation(ECMO) and continuous renal replacement therapy(CRRT) as well as heart lung transplantation during day 28-45 day post infection, and died on the second day post heart and lung transplantation. […] At the early stage of the disease, his symptoms were mild and the inflammatory indices increased and the lymphocyte count decreased continuously. […] His clinical manifestations could not be improved despite viral RNAs test results became negative. […] The pathological changes were mainly diffused pulmonary hemorrhagic injuries and necrosis, fibrosis, small vessel disease with cardiac edema and lymphocyte infiltration. Conclusions: The clinical course of COVID-19 can exacerbate rapidly from mild to critical with lung, liver and heart injuries. | 2020-05-26 |
| 32455517 | Up to date there is little known regarding the impact of this outbreak on spinal specialists’ daily clinical practice. | 2020-05-27 |
| 32455539 | The COVID-19 pandemic is marked by a wide range of clinical disease courses, ranging from asymptomatic to deadly. […] There have been many studies seeking to explore the correlations between COVID-19 clinical outcomes and various clinical variables, including age, sex, race, underlying medical problems, and social habits. […] These data provide a potential model for the increased susceptibility of smoking patients to COVID-19 and encourage further exploration into the androgen and tobacco upregulation of ACE2 to understand the potential clinical ramifications. | 2020-05-27 |
| 32455612 | The aim of this article was to review the available literature on the relevant aspects of dentistry in relation to COVID-19 and to discuss potential impacts of COVID-19 outbreak on clinical dentistry, dental education and research. […] Although the coronavirus pandemic has caused many difficulties for provision of clinical dentistry, there would be an opportunity for the dental educators to modernize their teaching approaches using novel digital concepts in teaching of clinical skills and by enhancement of online communication and learning platforms. […] In conclusion, COVID-19 has had many immediate complications for dentistry of which some may have further long-term impacts on clinical practice, dental education and dental research. | 2020-05-27 |
| 32455629 | Immediate availability for targeted experimental and clinical interrogations of potential COVID-19 pandemic mitigation agents, namely vitamin D and quercetin, as well as of the highly selective (Ki, 600 pm) intrinsically specific FURIN inhibitor (a1-antitrypsin Portland (a1-PDX), is considered an encouraging factor. […] Observations reported in this contribution are intended to facilitate follow-up targeted experimental studies and, if warranted, randomized clinical trials to identify and validate therapeutically viable interventions to combat the COVID-19 pandemic. […] In line with the results of present analyses, a randomized interventional clinical trial evaluating effects of estradiol on severity of the coronavirus infection in COVID19+ and presumptive COVID19+ patients and two interventional randomized clinical trials evaluating effects of vitamin D on prevention and treatment of COVID-19 were listed on the ClinicalTrials.gov website. | 2020-05-27 |
| 32455859 | This risk is even more serious in pediatric dentistry, since affected children, frequently, present an asymptomatic, mild or moderate clinical viral infection and, therefore, they may play a major role in community-based COVID-19 transmission. […] The aim of this paper is to provide clinical recommendations, presenting a needed tool for dentists to allow a valid and safe how-to-do protocol. | 2020-05-29 |
| 32455894 | In this manuscript, we address the unique issues regarding treatment prioritization for the patient with bladder cancer and how we at City of Hope have adjusted our clinical practices using a team-based approach that utilizes shared decision making with all stakeholders (physicians, patients, caregivers) to optimize outcomes during this difficult time. | 2020-05-27 |
| 32455961 | COVID-19 is a highly infectious respiratory disease which leads to several clinical conditions related to the dysfunction of the respiratory system along with other physical and psychological complaints. | 2020-05-29 |
| 32456064 | Mindful of their widespread popularity in the management of diabetes, addressing potential benefits and harms of novel antidiabetic drugs to clinical prognosis at the time of a COVID-19 pandemic deserves careful consideration. | 2020-05-29 |
| 32456286 | Further clinical studies are needed to verify the combination of HCQ and rIFN-ω will be effective and safe treatment for cats with FIP. | 2020-05-29 |
| 32456368 | Although the acute respiratory distress syndrome (ARDS) induced by COVID-19 is similar to the ARDS caused by other diseases in terms of pathophysiological basis and clinical manifestations, they are also different in many aspects, which lead to different clinical therapies. | 2020-05-29 |
| 32456404 | In response to the global coronavirus disease 2019 (COVID-19) emergency, clinical trial research assessing the efficacy and safety of experimental vaccines to prevent COVID-19 are emerging at an unprecedented rate. […] The aim of this systematic review is to summarize the preliminary experiences and ongoing clinical trials of the major candidates and challenges of the vaccine strategies in humans. […] Finally, we scrutinized the Cochrane COVID-19 study register and the COVID-19 section of ClinicalTrials.gov database for identifying relevant ongoing clinical trials. […] Our search identified 1359 published papers, 478 pre-print articles and 367 ongoing clinical trials. […] Finally, only ten ongoing clinical trials met the inclusion criteria. […] Specifically, seven developed vaccines for the S protein of SARS-CoV-2 and three clinical trials assessed the protective role of BCG vaccine against COVID-19. […] Notwithstanding the limitations of our analysis, given by the absence of available results, we try to provide a comprehensive view of the ongoing clinical trials in humans. | 2020-05-27 |
| 32456441 | This is problematic for HPE, which has traditionally relied on face-to-face learner interaction, in the form of skills laboratories, simulation training and industry-based clinical placements. | 2020-05-29 |
| 32456461 | Future work needs to be performed to support this hypothesis, both in in vitro models and preclinical studies. | 2020-05-29 |
| 32456489 | To add to the growing evidence on SARS-CoV-2 infection during pregnancy, so as to better inform clinical decision making and optimize patient outcomes. | 2020-05-27 |
| 32456506 | There is also growing evidence of potentially useful clinical biomarkers to predict COVID-19 progression and disease outcomes. | 2020-05-27 |
| 32456689 | Our results are in line with the most recent recommendations from the World Health Organization, namely, that the best strategy is the early detection and isolation of individuals with symptoms, followed by interventions and public recommendations aimed at reducing the transmissibility of the disease, which, although might not be sufficient for disease eradication, would produce as a second order effect a delay of several days in the raise of the number of infected cases. | 2020-05-29 |
| 32456753 | The COVID-19 pandemic is a rapidly evolving phenomenon that presents serious practical challenges and complex clinical considerations for health care workers, health care administrators, and policy formulators. The Senior Care Pharmacist carries periodic updates addressing matters relevant to pharmacotherapeutics and pharmacy practice as these relate to the care of older people in the time of the pandemic. | 2020-05-29 |
| 32456883 | In order to recover from this extraordinary level of suspended activity, we will be obliged to prioritize pathologies based on purely clinical criteria, for which tables including the relevance of each pathology within each area of urology are being proposed. | 2020-05-29 |
| 32456944 | In the form of a diary, we present the actions undertaken, the incidence of COVID-19 in patients and health staff, some clinical characteristics and the results of screening all the patients in the unit. […] We started with 90 patients on HD: 37 (41.1%) had COVID-19, of whom 17 (45.9%) were diagnosed through symptoms detected in triage or during the session, and 15 (40.5%) through subsequent screening of those who, until that time, had not undergone SARS-CoV-2 PCR testing. […] In terms of staff, of the 44 people involved, 15 (34%) had compatible symptoms, 4 (9%) were confirmed as SARS-CoV-2 PCR cases by occupational health, 9 (20%) required some period of sick leave, temporary disability to work (ILT), and 5 were considered likely cases. […] Most cases are managed as outpatients, however severe symptoms are also appearing and mortality to date is 16.2%. | 2020-05-29 |
| 32456948 | Medical records including demographic data, medical history, clinical characteristics, laboratory examinations, chest computed tomography (CT), and treatment measures were collected, analyzed, and compared between the two groups. | 2020-05-29 |
| 32456959 | Coronavirus disease-2019 (COVID-19), caused by a novel coronavirus termed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has been linked to ocular signs and symptoms in several case reports. […] All health care professionals should ask patients about ocular symptoms consistent with SARS-CoV-2, and use eye protection such as goggles or face shields as part of the standard personal protective equipment for high-risk patients in addition to wearing of masks by both the patient and provider, and should consider tears to be potentially infectious. | 2020-05-29 |
| 32457027 | To appraise the availability, quality, and inclusivity of clinical guidelines produced in the early stage of the coronavirus disease 2019 (covid-19) pandemic. […] Clinical guidelines for the management of covid-19, Middle East respiratory syndrome (MERS), and severe acute respiratory syndrome (SARS) produced by international and national scientific organisations and government and non-governmental organisations relating to global health were included, with no exclusions for language. […] The quality and contents of early covid-19 guidelines were also compared with recent clinical guidelines for MERS and SARS. 2836 studies were identified, of which 2794 were excluded after screening. […] Overall, the clinical guidelines lacked detail and covered a narrow range of topics. […] A framework for development of clinical guidelines during public health emergencies is needed to ensure rigorous methods and the inclusion of vulnerable populations. | 2020-05-28 |
| 32457035 | Recent studies have shown that patients with COVID-19 experience relevant gastrointestinal (GI) symptoms. […] We aimed to perform a systematic review and meta-analysis on the GI symptoms of COVID-19. […] A systematic review of GI symptoms and a meta-analysis comparing symptoms in severe and non-severe patients was performed using RevMan V.5.3. […] Our study revealed that diarrhoea (7.8%) followed by nausea and/or vomiting (5.5 %) were the most common GI symptoms. […] We performed a meta-analysis comparing the odds of having GI symptoms in severe versus non-severe COVID-19-positive patients. 4 studies for nausea and/or vomiting, 5 studies for diarrhoea and 3 studies for abdominal pain were used for the analyses. […] Our study has reiterated that GI symptoms are an important clinical feature of COVID-19. | 2020-05-28 |
| 32457036 | In this article, we propose guidance to the management of colorectal cancer during the pandemic, prioritised according to a three-tiered framework, based on expert clinical judgement and magnitude of benefit expected from specific interventions. | 2020-05-29 |
| 32457038 | Fortunately, there are such clinically approved molecules that elicit antiviral activity in pre-clinical studies, without causing NP-C disease. | 2020-05-27 |
| 32457048 | We examined differences in demographics, clinical features and outcomes of COVID-19 infection. […] Patients with and without rheumatic disease had similar symptoms and laboratory findings. […] Patients with rheumatic disease and COVID-19 infection were more likely to require mechanical ventilation but had similar clinical features and hospitalisation rates as those without rheumatic disease. | 2020-05-27 |
| 32457086 | Video consultations offer clinical assessment despite restricted movement of people.We undertook a rapid literature review to identify the highest currently available level of evidence to inform this major change in clinical practice. […] For patient safety, it will be critical to follow the WHO guidance regarding: a standard operating procedure; clinical protocols for when video consultations can (and cannot) be used; policies to ensure equity of access in disadvantaged populations; adequate staff training; and administrative support to coordinate appointments. | 2020-05-27 |
| 32457133 | COVID-19 is impacting provision of renal transplantation in the UK with a reduction in clinical activity. | 2020-05-27 |
| 32457227 | Evaluation of cause, clinical symptoms, and treatment response. […] It will be important to delineate the full clinical range of emergent COVID-19-related neurologic disease. | 2020-05-29 |
| 32457924 | Several reports on epidemiological and clinical features of the 2019 coronavirus disease (COVID-19) have been published. […] We examine the clinical and laboratory features of 14 patients who died of COVID-19. […] The clinical and laboratory parameters in the cohort of fatal cases may be incorporated into future clinical prognosis models and will be of help in understanding the pathogenesis of this disease. | 2020-05-27 |
| 32457932 | Regulatory and public health authorities recognize that CQ/HCQ may offer little clinical benefit and only add risk requiring further investigation before wider public distribution. | 2020-05-30 |
| 32458019 | There was no significant difference between the groups in terms of the length of preoperative symptoms or surgery, need for postoperative peritoneal drainage or the distribution of complicated versus uncomplicated appendicitis. | 2020-05-29 |
| 32458042 | Virtual interactive tools are well known in different clinical and surgical specialties, and they are considered as a valid support, but it seems that in plastic surgery they are not so used. | 2020-05-29 |
| 32458121 | In our experience, tracheostomy does not seem to influence the clinical course and prognosis of the disease, in the face of possible risks of contagion for healthcare workers. | 2020-05-29 |
| 32458125 | To summarize the chest CT imaging and clinical features of the initial COVID-19 patients and provide a clinical diagnostic method that is more effective and can be performed earlier. […] This retrospective study investigated the clinical, laboratory and imaging information of 25 patients in the Luoyang area. […] The median time from initial symptoms to diagnosis was 7 days. […] Ninety-two percent of patients had respiratory symptoms, and 8% of them had digestive symptoms. […] Fever (92%), cough (60%) and fatigue (56%) were the most common symptoms. | 2020-05-29 |
| 32458149 | In addition, sufficient pre-clinical rationale and evidence have been presented to use chloroquine for the treatment of COVID-19. | 2020-05-29 |
| 32458182 | Healthcare services must adapt to effectively juggle between pandemic management and maintenance of business-as-usual services so that both COVID-19 and non-COVID-19 patients receive appropriate clinical care. | 2020-05-29 |
| 32458193 | COVID-19 patients have presented with a number of different neurological symptoms such as headache, dizziness, hyposmia, and hypogeusia during the course of illness. | 2020-05-29 |
| 32458197 | While it mostly presents with respiratory symptoms, it has already been found that it could manifest with a series of neurological symptoms as well, either at presentation or during the course of the disease. […] Symptoms vary from non-specific such as headache or dizziness to more specific such as convulsions and cerebrovascular disease (CVD). […] Clinicians and especially internists, neurologists, and infectious disease specialists should be aware of these symptoms and able to recognize them early. | 2020-05-29 |
| 32458279 | Based on our data analysis, however, remdesivir with IV administration alone is unlikely to achieve excellent clinical efficacy. […] This analysis is based on the following observations: plasma exposures of remdesivir and its active metabolite are unlikely to be correlated with its clinical efficacy; remdesivir and its active metabolites are unlikely to be adequate in the lung to kill the SARS-CoV-2 virus. | 2020-05-29 |
| 32458356 | Although certain NCDs appear to increase the severity of COVID-19 and mortality risk, SARS-CoV-2 infection in survivors with NCDs may also affect the progression of their pre-existing clinical conditions. […] Infection containment measures will have substantial short- and long-term consequences; social distancing and quarantine restrictions will reduce physical activity and increase other unhealthy lifestyles, thus increasing NCD risk factors and worsening clinical symptoms. | 2020-05-29 |
| 32458395 | Since the outbreak of novel coronavirus (2019-nCoV), it became evident that a proportion of patients may present with gastrointestinal symptoms. […] We report the case of a Covid-19-infected patient who, during recovery from the pulmonary pneumonia, had gastrointestinal symptoms followed by a diastasic right colon perforation due to acute over distension of the bowel. […] This case highlights the importance of paying attention to initial gastrointestinal symptoms in order to prevent possible complications. | 2020-05-29 |
| 32458425 | Both patients, including an 81-year-old man who required extracorporeal membrane oxygenation, showed clinical improvement. | 2020-05-27 |
| 32458502 | SARS-CoV-2 is highly infectious, and infection by this virus results in COVID-19, manifesting predominantly respiratory symptoms in the lower respiratory system. […] Suspected COVID-19 patients who had a documented history of exposure and exhibited symptoms, but did not have positive PCR test results, were generally self-quarantined with prescriptions aiming to help attenuate their symptoms. […] There is an urgent need of alternative medicine to help patients relieve symptoms during self-quarantine, and to potentially help increase their chances of survival and recovery from the infection. […] This patient went through severe COVID-19 but eventually recovered upon the implementation of this treatment regimen, suggesting potential therapeutic effects of diammonium glycyrrhizinate as alternative medicine to help relieve COVID-19 symptoms. | 2020-05-27 |
| 32458550 | This study aimed to estimate the association between anxiety associated with COVID-19 and somatic symptoms, using data from a large, representative sample (N = 2,025) of the UK adult population. […] Results showed that moderate to high levels of anxiety associated with COVID-19 were significantly associated with general somatic symptoms and in particular with gastrointestinal and fatigue symptoms. | 2020-05-27 |
| 32458588 | During remote-visits several interventions were conducted: triage for COVID-19 suspected symptoms, email check of clinical pictures and of laboratory examinations, advices for topical and systemic therapy continuation or discontinuation/switch and re-schedule of next appointment. | 2020-05-27 |
| 32458596 | The increasing spread of COVID-19 presents challenges for the clinical care of patients with gynecological malignancies. | 2020-05-27 |
| 32458599 | Currently, chloroquine phosphate and hydroxychloroquine sulfate, two chloroquine derivatives, are under clinical use. […] This paper summarizes the currently available data and experiences from clinical treatment for malaria with chloroquine drugs, so as to provide insights into the more rational use of chloroquine agents for the treatment of COVID-19. ［摘要］ 2019 年底, 我国湖北省武汉市出现了新型冠状病毒肺炎 疫情, 随后在全国扩散并成为全球大流行。 | 2020-05-28 |
| 32458969 | Hydroxychloroquine+azithromycin has been widely misrepresented in both clinical reports and public media, and outpatient trials results are not expected until September. […] Five studies, including two controlled clinical trials, have demonstrated significant major outpatient treatment efficacy. | 2020-05-27 |
| 32459003 | Therefore adjuvants such as retinoids, capable of increasing IFN-I mediated anti-viral responses should be tested in combinations of IFN-I and anti-viral drugs in pre-clinical studies of SARS-CoV-2. | 2020-05-27 |
| 32459123 | Given the threat to public health posed by sequelae of SARS-CoV-2 infection, the literature surrounding patient presentation in severe and non-severe cases, transmission rates and routes, management strategies, and initial clinical trial results have become available at an unprecedented pace. […] In this review we collate current clinical and immunologic reports, comparing these to reports of previous coronaviruses to identify mechanisms driving progression to severe disease in some patients. […] Finally, we extend these findings to suggest possible treatment options that may merit investigation in randomized clinical trials. | 2020-05-27 |
| 32459186 | The goal of the present study was to examine whether stay-at-home orders produced differential changes in mental health symptoms using internet search queries at a national scale. […] Although more research is needed to examine sustained effects, these results suggest mental health symptoms were associated with an immediately leveling off following the issuance of stay-at-home orders. | 2020-05-27 |
| 32459192 | The global coronavirus disease 2019 (COVID-19) has presented major challenges for clinical laboratories, from initial diagnosis to patient monitoring and treatment. […] Initial response to this pandemic involved the development, production, and distribution of diagnostic molecular assays at an unprecedented rate, leading to minimal validation requirements and concerns regarding their diagnostic accuracy in clinical settings. […] In both cases, the lack of peer-reviewed data and regulatory oversight, combined with general misconceptions regarding their appropriate use, have highlighted the importance of laboratory professionals in robustly validating and evaluating these assays for appropriate clinical use. […] The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Task Force on COVID-19 has been established to synthesize up-to-date information on the epidemiology, pathogenesis, and laboratory diagnosis and monitoring of COVID-19, as well as to develop practical recommendations on the use of molecular, serological, and biochemical tests in disease diagnosis and management. […] This review summarizes the latest evidence and status of molecular, serological, and biochemical testing in COVID-19 and highlights some key considerations for clinical laboratories operating to support the global fight against this ongoing pandemic. | 2020-05-27 |
| 32459529 | PubMed (via MEDLINE), EMBASE (via Ovid), Scopus, Web of Science, Cochrane Library, bioRxiv, Preprints, ClinicalTrials.gov, World Health Organization International Clinical Trials Registry Platform, and the Chinese Clinical Trials Registry from 1 December 2019 until 8 May 2020. […] Evidence was conflicting and insufficient regarding the effect of hydroxychloroquine on such outcomes as all-cause mortality, progression to severe disease, clinical symptoms, and upper respiratory virologic clearance with antigen testing. | 2020-05-27 |
| 32459574 | Sequential analysis has not been frequently used in many clinical trials where it should have been used. | 2020-05-27 |
| 32459655 | We developed a web-based 36-item survey questionnaire by analyzing a preceding qualitative interview study with ICU staff about clinical requirements of future patient monitoring. | 2020-05-27 |
| 32459664 | Two population-based surveys on coronavirus disease-2019 (Covid-19)-like symptoms were conducted by BVA-Doxa on representative samples of the general population from Italy and its largest region, Lombardy, with over 10 million inhabitants and heavily struck by Covid-19, on 27-30 March and 3-7 April, on a total of 2000 individuals - 353 from Lombardy. […] Overall, 14.2% of Italians - and 19.6% in Lombardy - reported Covid-19-like symptoms. […] Although the influenza season was ended by mid-March, at least part of the symptoms may be not Covid-19 related. | 2020-05-27 |
| 32459672 | Clinical course and laboratory metrics were compared between patients that developed venous thromboembolism and patients that did not develop venous thromboembolism. | 2020-05-27 |
| 32459675 | In mid-March, medical schools suspended all clinical rotations for the remainder of the 2019-2020 academic year. […] As such, third-year medical students may not be able to complete sufficient clinical experiences to make important career choices before they have to submit their residency applications. […] While the decision to suspend clinical rotations was necessary to protect students, specialty organizations and residency programs must mitigate the deficits in students’ clinical education caused by the COVID-19 pandemic.In this Perspective, the authors identify potential challenges for third-year medical students and advocate for solutions to improve the residency application process for students and programs. […] First, they propose delaying the date that programs can access applicant data through the Electronic Residency Application Service, thereby affording students more time to complete clinical experiences, solidify their specialty decision, and strengthen their residency application. | 2020-05-27 |
| 32459701 | To characterize symptoms and disease severity among pregnant women with coronavirus disease 2019 (COVID-19) infection, along with laboratory findings, imaging, and clinical outcomes. […] Women were diagnosed with COVID-19 infection based on either universal testing on admission or testing because of COVID-19-related symptoms. […] Clinical and demographic risk factors for moderate or severe disease were analyzed and calculated as odds ratios (ORs) with 95% CIs. […] Laboratory findings and associated symptoms were compared between those with mild or asymptomatic and moderate or severe disease. […] The clinical courses and associated complications of women hospitalized with moderate and severe disease are described. […] Two women underwent preterm delivery because their clinical status deteriorated. | 2020-05-27 |
| 32459790 | Epidemiologic data, previous clinical characteristics, support therapy needed, imaging tests, laboratory observations on admission, and pharmacologic therapy. […] Respiratory symptoms and fever were prevalent. […] Respiratory symptoms were the leading cause of PICU admission, making respiratory support the principal therapy. | 2020-05-30 |
| 32459792 | The most popular tweets shared on Twitter were open-access resources, including links for updated literature, narrative reviews, and educational videos relevant to coronavirus disease 2019 clinical care. | 2020-05-30 |
| 32459793 | Experienced clinicians served as participants, debriefed, and provided feedback that was incorporated into local site clinical pathways, job aids, and suggested practices. […] Clinical management of an actual suspected coronavirus disease 2019 patient with difficult airway demonstrated very similar success and anticipated failure points. […] Following debriefing and assembly of a success/failure grid, a coronavirus disease 2019 airway bundle template was created using these simulations and clinical experiences for others to adapt to their sites. | 2020-05-27 |
| 32459857 | We suggest that it is possible to hypothesise a spectrum of secondarily acquired, prothrombotic coagulopathy mediated by the endothelial interaction with SARS-CoV-2 as a cause of mortality in a subset of patients with a complicated clinical course of COVID-19. | 2020-05-29 |
| 32459916 | Black race was not associated with higher in-hospital mortality than white race, after adjustment for differences in sociodemographic and clinical characteristics on admission. | 2020-05-27 |
| 32459919 | The primary end point was clinical status on day 14, assessed on a 7-point ordinal scale. […] At baseline, patients randomly assigned to the 10-day group had significantly worse clinical status than those assigned to the 5-day group (P = 0.02). […] By day 14, a clinical improvement of 2 points or more on the ordinal scale occurred in 64% of patients in the 5-day group and in 54% in the 10-day group. […] After adjustment for baseline clinical status, patients in the 10-day group had a distribution in clinical status at day 14 that was similar to that among patients in the 5-day group (P = 0.14). | 2020-05-27 |
| 32459978 | The objective of this study was to rate the adequacy of healthcare workers (HCWs) and hospital settings on RID prevention using unannounced standardized patients (USP) in clinical settings of hospital gateways. […] Trained USPs visited 5 clinical settings: information desks, registration desks, two outpatient departments and the emergency departments in 10 hospitals across 3 cities of Inner Mongolia, China. […] USPs observed the hospital air ventilation and distance from the nearest hand-washing facilities to each clinical setting, then mimicked symptoms of either tuberculosis or influenza before observing the HCW’s behavior. […] A total of 480 clinical-setting assessments were made by 19 USPs. […] Compared to the information desk, adequacy of triage and preventing the spread of airborne droplets by physicians in the three clinical departments was less likely to be adequate. […] Triage services for USPs simulating symptoms of influenza were 2.6 times more likely to be adequate than for those simulating symptoms of tuberculosis but there was no significant difference in the prevention of the spread of airborne droplets. | 2020-05-27 |
| 32460086 | Collected data included the current MS DMT and patient-reported disability level, history of recent sick contact, recent fever, respiratory symptoms, diagnosis with COVID-19, and the disposition after the diagnosis. […] We calculated the proportion of COVID-19-suspect patients and compared their demographics, clinical characteristics, and DMT categories with the rest of survey-responders, using univariable and multivariable models. | 2020-05-29 |
| 32460144 | The infection has been associated with a wide range of clinical symptoms. | 2020-05-29 |
| 32460173 | In the context of the pandemic, the rapid emergency use authorisation of diagnostic assays for SARS-CoV-2 has meant there are few peer-reviewed published studies of clinical performance of commercial assays. […] To evaluate the clinical performance of AusDiagnostics respiratory multiplex tandem PCR assay including SARS-CoV-2. | 2020-05-29 |
| 32460229 | A total of 198 chains of transmission together with dates of symptoms onset and 139 dates of infections were identified among 14,829 confirmed cases outside Hubei Province as reported as of March 31, 2020. | 2020-05-29 |
| 32460302 | As the coronavirus disease 2019 (COVID-19) continues to spread across the globe, the knowledge of its epidemiology, clinical features, and management is rapidly evolving. […] Some present with several days of malaise, gastrointestinal symptoms, and consequent hypovolemia requiring aggressive fluid resuscitation, while a subset develop acute respiratory distress syndrome with renal dysfunction and lingering congestion necessitating restrictive fluid management. | 2020-05-27 |
| 32460349 | Using clinical data and images, the authors of a recent nationwide Spanish survey identified 5 clinical patterns which were associated with different patient demographics, onset (timing), and prognosis. | 2020-05-27 |
| 32460358 | We focus on vaccine development in the UK and vaccines which have entered clinical trials around the world. | 2020-05-27 |
| 32460369 | Clinical trials on application of NSAIDs in viral respiratory infections were included. […] Six clinical trials were included. […] No clinical trial has been performed on COVID-19, Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome infections. […] Studies show that ibuprofen and naproxen not only have positive effects in controlling cold symptoms but also do not cause serious side effects in rhinovirus infections. […] Although based on existing evidence, NSAIDs have been effective in treating respiratory infections caused by influenza and rhinovirus, since there is no clinical trial on COVID-19 and case-reports and clinical experiences are indicative of elongation of treatment duration and exacerbation of the clinical course of patients with COVID-19, it is recommended to use substitutes such as acetaminophen for controlling fever and inflammation and be cautious about using NSAIDs in management of COVID-19 patients until there are enough evidence. […] Naproxen may be a good choice for future clinical trials. | 2020-05-27 |
| 32460390 | Data on the clinical course of COVID-19 in immunosuppressed patients are limited and the effective treatment strategy for these patients is unknown. […] Demographic, clinical and treatment data were extracted from the electronic patient files. […] The presenting symptoms were similar to non-immunocompromised patients Eighty-three percent (19/23) of the patients required hospitalization but only two of these were transferred to the intensive care unit. […] Five patients died from COVID-19; all had high Clinical Frailty scores. | 2020-05-27 |
| 32460417 | The new disease caused primarily symptoms of a respiratory tract infection with cough, shortness of breath, and viral pneumonia. […] The clinical spectrum showed mostly mild symptoms with some patients developing bilateral pneumonia needing partly intensive care treatment and causing death(1). | 2020-05-27 |
| 32460433 | We aim to study predictors of trainee well-being and changes to clinical practice using an anonymous survey of American urology residents. | 2020-05-27 |
| 32460440 | The infectionhas an estimated incubation period of 1-14 days and its clinical manifestations and symptoms include cough, fever and shortness of breath (Zhuet al., 2020). | 2020-05-27 |
| 32460453 | This retrospective case series highlights the challenges primary care clinicians face in the early identification of suspect cases based on clinical criteria only. […] To improve case detection, clinicians can sharpen their clinical acumen by keeping abreast with the latest COVID-19 developments and by maintaining a high state of vigilance. | 2020-05-28 |
| 32460457 | Patients were closely observed by doctors or nurses’ interviews twice a day and transferred to hospitals when symptoms worsened. […] Of 113 patients, 54 (47.8%) were asymptomatic at diagnosis, and 15 (13.3%) had no symptoms until they were released from isolation. | 2020-05-28 |
| 32460566 | Students reported a basic level of COVID-19 knowledge, but few students (18%, n = 173/966) correctly identified all three signs and/or symptoms of COVID-19. | 2020-05-28 |
| 32460624 | Depending on the amount of cytokines released as the result of the immunological activation induced by SARS-CoV2, three major clinical phenotypes can be identified: “mild”,symbolized as a “drizzle” of cytokines, severe as a “storm”, and critical as a “hurricane”. […] In patients with mild symptoms, the release of pro-inflammatory cytokines is balanced to obtain a defense response against the virus which is often self-limiting and overcomes without tissue damage. | 2020-05-28 |
| 32460632 | Herpesvirus infections can occur as primary or nosocomial pathogens but clinical manifestations most commonly are re-activation of latent viral infection. […] This is an area of active study, and further research is needed to better understand the risks, clinical manifestations, and attributable morbidity and mortality of viral infections. Conclusions: Major burn injury results in immunosuppression and viral infection in a small number of patients. | 2020-05-28 |
| 32460829 | An IRB-approved prospective registry was set up at ICH on March 13, 2020, for all breast cancer patients with COVID-19 symptoms or radiologic signs. […] Registered data included patient history, tumor characteristics and treatments, COVID-19 symptoms, radiological features, and outcome. […] Common clinical features mostly consisted of fever and/or cough, while ground-glass opacities were the most common radiologic sign at diagnosis. | 2020-05-29 |
| 32460839 | The pulmonary function and symptoms of the patient with COVID-19 pneumonia was significantly improved in 2 days after hWJC transplantation, and recovered and discharged in 7 days after treatment. | 2020-05-30 |
| 32461068 | Administrative support with the aim of zero nosocomial transmission by reducing elective clinical services, decanting wards, mobilizing isolation facilities, providing adequate personal protective equipment, coordinating laboratory network for rapid molecular diagnosis under 4-tier active surveillance for hospitalized- and out-patients, and organizing staff forum and training was implemented under the framework of preparedness plan in Hospital Authority. | 2020-05-30 |
| 32461198 | Hypertension and CVD, after the adjustment for other clinical and demographic parameters, primarily age, did not remain independent predictors of the lethal outcome in COVID-19 patients. | 2020-05-31 |
| 32461285 | The false negative rate of the Accula POC test calls for a more thorough evaluation of POC test performance characteristics in clinical settings, and for confirmatory testing in individuals with moderate to high pre-test probability of SARS-CoV-2 who test negative on Accula. | 2020-05-28 |
| 32461325 | Anosmia and dysgeusia have been reported as potential symptoms of coronavirus disease 2019. […] This study aimed to confirm whether anosmia and dysgeusia are specific symptoms among those who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] Clinical symptoms and comorbidities associated with anosmia and dysgeusia were obtained by telephone interview with a standardized questionnaire. […] The symptoms independently associated with SARS-CoV-2 positivity in conditional logistic regression were anosmia or dysgeusia or both (adjusted odds ratio [OR] 62.9, 95% confidence interval [CI] 11.0-359.7), presence of myalgia (adjusted OR 7.6, 95% CI 1.9-29.9), blurred vision (adjusted OR 0.1, 95% CI 0.0-0.8) and chest pain (adjusted OR 0.1, 95% CI 0.0-0.6). […] We found a strong association between olfactory and gustatory symptoms and SARS-CoV-2 positivity. […] These symptoms should be considered as common and distinctive features of SARS-CoV-2 infection and should serve as an indication for testing and possible retesting of people whose first test result is negative. | 2020-05-28 |
| 32461326 | We aimed to describe the clinical characteristics and outcomes of critically ill patients with coronavirus disease 2019 (COVID-19) in a Canadian setting. | 2020-05-28 |
| 32461415 | Overall, 7,008 tele-calls were addressed, of which 2,805 (40.02%) patients where a clinical-related query was answered were included for analysis. […] Tracking of tele-consultations and access to patient information from the electronic medical records enabled a timely response in an ongoing lockdown due to the COVID-19 pandemic. | 2020-05-29 |
| 32461554 | Recent clinical trials have demonstrated that colchicine may have metabolic and cardiovascular and benefits in at-risk patients; however, the mechanisms through which colchicine may improve outcomes are still unclear. | 2020-05-31 |
| 32461867 | COVID-19 will likely impact UME in the suspension of clinical rotations, alterations in grading, suspension or elimination of away rotations, changes in medical licensing exams, and ramifications on mental health. | 2020-05-30 |
| 32461981 | As of Feb. 9, 2020, a total of 40,260 patients have been diagnosed with NCP, and 23,589 patients were suspected to have infected by the 2019 novel coronavirus (COVID-19), which puts forward a great challenge for public health and clinical treatment in China. | 2020-05-30 |
| 32462195 | To evaluate the clinical performance of 3 molecular assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). | 2020-05-28 |
| 32462267 | As cardiovascular patients are at high risk but also have dyspnea and fatigue as leading symptoms, prevention, diagnostics and treatment in these patients are important to provide adequate care for those with or without COVID-19 but most importantly when comorbid cardiovascular conditions are present. | 2020-05-30 |
| 32462305 | There were a total of 21 studies with 3714 COVID-19 patients, and urinary symptoms were absent in all of them. | 2020-05-30 |
| 32462354 | There is a global concern of increasing number of children presenting with inflammatory syndrome with clinical features simulating Kawasaki disease, during ongoing COVID-19 pandemic. […] His clinical condition improved rapidly, was afebrile from day 2, inflammatory parameters decreased, left ventricular function improved and was discharged after 6 d of hospital stay. | 2020-05-28 |
| 32462378 | The data of 32 hemodialysis patients with COVID-19, including epidemiological, demographic, clinical, laboratory, and radiological, were collected from the Blood Purification Department of Wuhan Fourth Hospital from February 3 to 16, 2020. […] Common symptoms included fever (15 cases), cough (21 cases), and fatigue (7 cases). | 2020-05-30 |
| 32462412 | Historically, the group of human coronaviruses can also affect the central nervous system leading to neurological symptoms; however, the causative mechanisms of the neurological manifestations of COVID-19 disease are not well known. […] They developed acute encephalopathy days into their hospitalization with clinical and electrographic seizures. […] Clinical (motor) seizures may not be readily detected in this population due to the expansive utilization of sedatives and paralytics for respiratory optimization strategies. […] Previously, several neurological symptoms were seen in patients with more advanced COVID-19 disease, and these were thought to be secondary to multi-system organ failure and/or disseminated intravascular coagulopathy-related brain injury. […] Patients with clinical signs of seizures or otherwise unexplained encephalopathy may benefit from electroencephalography monitoring and/or empiric anti-epileptic therapy. | 2020-05-30 |
| 32462423 | In Italy, from March 8, 2020, all the deferrable clinical activities have been suspended to increase the health care offer for COVID-19 patients. | 2020-05-30 |
| 32462468 | New epidemiological data and clinical findings are emerging on a daily basis, making it critical to always refer to the latest information. | 2020-05-30 |
| 32462545 | Further work is needed to prioritize drugs for investigation in well-controlled clinical trials and treatment protocols. | 2020-05-30 |
| 32462663 | However, there is limited data regarding clinical features, disease courses and outcomes of COVID-19 in patients with human immunodeficiency virus (HIV). […] Herein, we presented the demographic data, clinical characteristics and outcomes of nine confirmed COVID-19 patients with HIV infection admitted to our hospital located in south Bronx, New York City. […] More research is needed to determine the impact of HIV on the clinical course of COVID-19. | 2020-05-28 |
| 32462666 | We read with interest the paper entitled «The impact of laryngopharyngeal reflux disease on 95 hospitalized patients with COVID-19 in Wuhan, China: A retrospective study.»1 The authors retrospectively reported that hospitalized patients with laryngopharyngeal reflux (LPR) had poorer clinical outcomes compared with those without LPR according to Reflux Symptom Index (RSI). | 2020-05-28 |
| 32462677 | Moreover, it is importante to highlight the difficulty found to distinguish Dengue fever and COVID-19 and its implications, which present similar laboratorial and clinical characteristics. | 2020-05-28 |
| 32462689 | All human coronaviruses have been variably associated with symptoms of gastroenteritis. | 2020-05-28 |
| 32462708 | In this piece, we describe the background literature and the approach we have taken at our institution as we care for a high burden of COVID-19 cases with respiratory symptoms. | 2020-05-28 |
| 32462717 | Two humanized monoclonal antibodies are in clinical trial following IL6R antagonist therapies namely tocilizumab and sarilumab. | 2020-05-28 |
| 32462732 | Clinical tools will be generated to inform emergency care, both during and beyond the COVID-19 pandemic. | 2020-05-28 |
| 32462970 | Lack of vaccine or antiviral drug with clinical efficacy suggested that drug repurposing approach may provide a quick therapeutic solution to COVID19. […] However, further studies on these drugs for evaluation of their clinical efficacy and dose formulations may be required, which may provide a quick therapeutic option to treat COVID-19.Abbreviation: COVID-19: Coronavirus Disease 2019; PCA: Principal Component Analysis; MD: Molecular Dynamics; MM/PBSA: Molecular Mechanics Poisson-Boltzmann Surface Area; nCoV: Novel Coronavirus; PME: Particle-Mesh Ewald; RMSD: Root Mean Square Deviations; RMSF: Root Mean Square Fluctuations; SARS-CoV-2: Severe Acute Respiratory Syndrome-Coronavirus-2; SASA: Solvent Accessible Surface Area; SPC: Simple Point Charge. | 2020-05-28 |
| 32462990 | A 57 year old patient presented to the emergency center with severe COVID-19 symptoms and developed massive pulmonary embolism. […] CDT can be an additional therapeutic option in patients with COVID-19 and pulmonary embolism that present with rapid clinical collapse. | 2020-05-28 |
| 32463026 | Clinical studies have documented that potentially severe neurological symptoms are associated with SARS-CoV-2 infection, thereby suggesting direct CNS penetration by the virus. | 2020-05-28 |
| 32463076 | Viral load of asymptomatic carriers is comparable to symptomatic patients, viral shedding is highest before symptom onset suggesting high transmissibility before symptoms. […] Extensive universal testing irrespective of symptoms may be considered with priority placed on groups with high frequency exposure to positive patients. | 2020-05-28 |
| 32463179 | In the absence of clinical trial results, we analyzed epidemiological data to support or discard such hypothesis. | 2020-05-28 |
| 32463186 | In this setting, pulmonary embolism may cause further respiratory distress and clinical deterioration. […] We describe the clinical course of three patients admitted with SARS-CoV-2 infection and respiratory distress, where pulmonary embolism was detected during the course of the hospitalisation. […] Further research is required to establish appropriate clinical management guidelines for prevention of thromboembolic complications in COVID-19. | 2020-05-29 |
| 32463289 | Data from a Veterans Affairs medical center’s posttraumatic stress disorder clinical team suggest that not only are veterans interested in continuing with treatment but also that the treatments can be modified to accommodate the current climate. | 2020-05-28 |
| 32463308 | In addition to flu-like respiratory symptoms, acute cardiac manifestations include cardiac injury, shock and arrhythmia. […] How great the risk is relative to the benefit in critically ill COVID-19 patients will need to await the outcome of ongoing, controlled clinical trials. | 2020-05-28 |
| 32463348 | Background Despite a lack of clinical evidence, hydroxychloroquine and azithromycin are being administered widely to patients with verified or suspected COVID-19. | 2020-05-28 |
| 32463367 | People’s anxieties and worries were closely related with physical symptoms and self-protection methods. […] While relatively appropriate to suspect physical symptoms, a high proportion of answers related to self-protection methods were assessed as misinformation or advertisements. | 2020-05-28 |
| 32463395 | Clinical presentations and pathological mechanisms of COVID-19 are broad. | 2020-05-28 |
| 32463543 | Moreover, evaluating and treating HF patients with comorbid COVID-19 represents a formidable clinical challenge as symptoms of both conditions may overlap and they may potentiate each other. […] Therefore, the Heart Failure Association of the European Society of Cardiology and Chinese Heart Failure Association & National Heart Failure Committee conducted web-based meetings to discuss these unique clinical challenges and reach a consensus opinion to help providers worldwide deliver better patient care. | 2020-05-28 |
| 32463545 | The clinical manifestations of COVID-19 run from asymptomatic disease to severe acute respiratory syndrome. | 2020-05-28 |
| 32463802 | 45.1% of programs reported at least one resident with confirmed COVID-19: 101 resident physicians were confirmed COVID-19-positive, with an additional 163 residents presumed positive for COVID-19 based on symptoms but awaiting or unable to obtain testing. | 2020-05-28 |
| 32463803 | We performed a flow cytometric characterization of immune cells subsets from 30 COVID-19 patients and correlated these data with clinical outcomes. […] This study was supported by funds of Dept. of Experimental and Clinical Medicine of University of Florence (ex-60%) derived from Ministero dell’Istruzione, dell’Università e della Ricerca (Italy). | 2020-05-28 |
| 32463809 | During March 29-April 23, all SNF residents, regardless of symptoms, underwent serial (approximately weekly) nasopharyngeal SARS-CoV-2 RT-PCR testing, and positive results were communicated to the county health department. […] All SNF clinical and nonclinical staff members were also screened for SARS-CoV-2 by RT-PCR during March 29-April 10. […] Among these residents, eight developed symptoms 1-5 days after specimen collection and were later classified as presymptomatic; one of these patients died. | 2020-05-29 |
| 32464084 | The aim of this ongoing study is to present the current epidemiological and sociodemographic parameters of 380 COVID-19 patients diagnosed at the University Clinical Hospital Mostar (UCH Mostar) during the first two months of the COVID-19 pandemic. | 2020-05-28 |
| 32464158 | After obtaining their informed consent, we retrospectively analyzed the clinical characteristics of patients, including routine blood and biochemical data. | 2020-05-30 |
| 32464271 | Here, we suggest that this disparity in fatality rates may be attributed to SARS-CoV-2 evolving mutations and urge the international community to begin addressing the phylogenetic clade classification of SARS-CoV-2 in relation to clinical outcomes. | 2020-05-30 |
| 32464297 | Prevention the transmission of COVID-19 to the HCWs, four primary themes should be taken into consideration; (1) ongoing education and importance of the organization of the healthcare facility, (2) proper clinical triage and isolation of the suspected or confirmed COVID-19 patients in the outpatient clinics and in the emergency departments, (3) necessity of the organization of the COVID-19 wards, and (4) utilization of personal protective equipment. | 2020-05-30 |
| 32464333 | SARS-CoV-2 RNA detection was accomplished in volumes of 250 ml of wastewaters collected in areas of high (Milan) and low (Rome) epidemic circulation, according to clinical data. | 2020-05-30 |
| 32464367 | CNS manifestations include: headache and decreased responsiveness considered initial indicators of potential neurological involvement; anosmia, hyposmia, hypogeusia, and dysgeusia are frequent early symptoms of coronavirus infection. | 2020-05-30 |
| 32464579 | Based on clinical signs, 71 (74.7%), 22 (23.2%), and 2 (2.1%) patients had mild or moderate, severe, and critical disease, respectively. | 2020-05-30 |
| 32464585 | We report a para-infectious encephalitis patient with clinical, laboratory, and imaging findings during evolution and convalescence phase of coronavirus infection. | 2020-05-30 |
| 32464587 | The outcome of these simulations is in accordance with literature data measured in the clinical environment. […] The new IABP module is easy to manage and can be used as a training tool in a clinical setting. | 2020-05-31 |
| 32464662 | We modified workflows, deployed home workstations, and changed staffing models with the goal of providing additional clinical support to bedside colleagues while reducing exposure time and conserving personal protective equipment for those caring for this highly contagious patient population. […] Tele-intensive care unit nursing provided clinical knowledge to the nurses covering current and expanded critical care units. | 2020-05-28 |
| 32464685 | Nevertheless, the COVID-19 pandemic led to a drastic reduction of routine clinical activities and a consequent risk of looser connections between LVAD patients and their referring center. | 2020-05-28 |
| 32464700 | Preliminary clinical data fully support such initiatives. […] The response to the COVID-19 epidemic highlights the importance of capacity building for an organized and sustainable national blood system while steps are taken to provide appropriately collected, tested and processed COVID-19 convalescent plasma for investigational clinical use. | 2020-05-28 |
| 32464707 | We describe cases of patients in New York City presenting with stroke secondary to large vessel thrombosis without occlusion, incidentally found to have COVID-19 with only mild respiratory symptoms. | 2020-05-28 |
| 32466164 | We evaluated the mental health burden of coronavirus disease (COVID-19) on physical therapists, including their stress and anxiety levels, who were at risk of developing psychological distress and other mental health symptoms. […] Among the 65 physical therapists who completed our survey, 21 (32.3%) and 12 (18.5%) physical therapists reported having symptoms of anxiety and depression, respectively. | 2020-05-29 |
| 32466458 | A comprehensive strategy, including surveillance, diagnostics, research, clinical treatment, and development of vaccines, is urgently needed to win the battle against COVID-19. | 2020-06-02 |
| 32466477 | Vaccines for SARS-CoV-2 are under development, and clinical trials of several drugs are ongoing. international cooperation is an important way to accelerate research progress and achieve success. | 2020-05-29 |
| 32466623 | We investigated whether lung function measurements at home were comparable to measurements during clinical visits. […] Paired FEV1 measurements were included if the measurement on the home monitor was performed on the same day as the FEV1 measurement on the pneumotachometer during a two monthly clinical visit. […] The mean difference (home measurement was subtracted from clinical measurement) in FEV1 was 0.18 L in CF (95% confidence interval (CI) 0.08-0.27 L; p < 0.001) and 0.12 L in asthma (95%CI 0.05-0.19 L; p < 0.001). […] FEV1 measurements at home were significantly lower than clinically obtained FEV1 measurements, which has implications for the application of this technique in the daily clinical situation. | 2020-05-29 |
| 32466735 | The aim of this study was to describe specific clinical characteristics and outcomes of patients with COVID-19 with a history of stroke. […] Clinical data were analyzed and compared between patients with and without a history of stroke. […] Patients with COVID-19 with a history of stroke had more severe clinical symptoms and poorer outcomes compared with those without a history of stroke. | 2020-05-29 |
| 32466736 | Baseline clinical and radiological findings, treatment, and short-term outcomes are reported. […] Seven had none or mild symptoms of COVID-19 at stroke onset. […] Median time from COVID-19 symptoms to stroke onset was 6 days. […] All patients had brain imaging within 3 hours from symptoms onset. | 2020-05-29 |
| 32466738 | Time of arrival from symptoms onset to stroke units was delayed >30 minutes, reperfusion therapy cases fell, and door-to-needle time started 16 minutes later than usual. […] It is critical to encourage patients to continue seeking emergency care if experiencing acute stroke symptoms and to ensure that emergency professionals continue to use stroke code activation and telestroke networks. | 2020-05-29 |
| 32466830 | An electronic questionnaire was applied that was designed to evaluate the knowledge of symptoms, risk groups for severe disease, prevention measures, and the reprocessing of endoscopes utilized in patients with COVID-19. […] Ninety-five percent of them correctly identified the most frequent symptoms of the virus, and 60% identified the 3 risk groups for severe disease. […] The majority of the gastroenterologists and endoscopists surveyed were familiar with the signs and symptoms of COVID-19 and the populations at risk for complications. […] There was a lack of knowledge about prevention measures (during clinical care and endoscopic procedures) and the reprocessing of endoscopic equipment by 70% and 48%, respectively, of those surveyed. | 2020-06-04 |
| 32466862 | The main objective was to find evidence of clinical interest to support the relationship between anosmia and COVID-19. | 2020-05-31 |
| 32467007 | The viral load, complete blood count, inflammatory indicators, vital signs, and clinical symptoms were observed before and after COVID-19 convalescent plasma transfusion. […] After convalescent plasma transfusion, significant improvement was observed on laboratory indicators and clinical symptoms of the patient. | 2020-05-31 |
| 32467031 | This Cardiac Society of Australia and New Zealand (CSANZ) Imaging Council Position Statement aims to guide local, regional and national clinical practice, and facilitate resource and echocardiographic service planning appropriately during the current COVID-19 global pandemic. | 2020-06-01 |
| 32467101 | The pandemic is the cause of significant mortality and with this the need for rapidly disseminated information for palliative care professionals regarding the prevalence of symptoms, their intensity, their resistance or susceptibility to symptom control and the mode of death for patients. […] We undertook a systematic review of published evidence for symptoms in patients with COVID-19 (with a specific emphasis on symptoms at end of life) and on modes of death. […] Cough, breathlessness, fatigue and myalgia are significant symptoms in people hospitalised with COVID-19. […] Rapid data gathering on the mode of death and the profile of symptoms in the dying and their prevalence and severity in areas where COVID-19 is prevalent will provide important intelligence for clinicians. […] This should be done urgently, within ethical norms and the practicalities of a public health, clinical and logistical emergency. | 2020-05-29 |
| 32467113 | To examine presentation and outcomes of COVID-19 in patients with ESKD on dialysis, we retrospectively collected clinical data on 59 patients on dialysis who were hospitalized with COVID-19. […] The most common presenting symptoms were fever (49%) and cough (39%); initial radiographs most commonly showed multifocal or bilateral opacities (59%). | 2020-05-29 |
| 32467124 | We present a case of a patient with minimal respiratory symptoms but prominent bilateral groundglass opacities in a ‘crazy paving’ pattern on chest CT imaging and a negative initial infectious workup. […] This case illustrates the importance of clinical vigilance to retest patients for COVID-19, particularly in the absence of another compelling aetiology. | 2020-05-29 |
| 32467190 | Miller Fisher syndrome has recently been described in the clinical setting of the novel coronavirus disease 2019 (COVID-19) without accompanying imaging. | 2020-05-29 |
| 32467191 | Clinical and imaging data were extracted, reviewed, and analyzed. | 2020-05-29 |
| 32467359 | To protect medical laboratory personnel from infection, most laboratories inactivate the clinical samples before testing. | 2020-05-29 |
| 32467423 | Due to the lack of prospective, randomized, controlled clinical studies on inflammation and cardiovascular involvement, the exact mechanism of cardiac injury among patients with COVID-19 still remains uncertain. | 2020-06-16 |
| 32467443 | D-dimers and fibrinogen levels should be monitored, and all hospitalized patients should undergo thromboembolism prophylaxis with an increase in therapeutic anticoagulation in certain clinical situations. | 2020-05-31 |
| 32467452 | Coronavirus disease 2019 (COVID-19) symptoms in children are incompletely described. […] This case underlines the need for further study of the clinical presentation of pediatric COVID-19 and the potential association with nonrespiratory symptoms. | 2020-05-29 |
| 32467457 | The respiratory symptoms were not dominant or were absent. | 2020-05-29 |
| 32467554 | Although the majority of patients presented with respiratory-related symptoms, COVID-19 patients may present atypically with neurological manifestations and may even have an increased risk of stroke. | 2020-05-29 |
| 32467561 | Thus, given the key role of the immune system in COVID-19, a deeper understanding of the mechanism behind the immune dysregulation might give us clues for the clinical management of the severe cases and for preventing the transition from mild to severe stages. | 2020-06-12 |
| 32467809 | Our patient received intravenous antibiotics for seven days with a significant improvement in symptoms. | 2020-05-29 |
| 32467810 | The Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the most talked-about clinical entity in early 2020. […] We believe that as more data becomes available, it is going to be necessary to publish detailed guidelines on how to approach this unique clinical challenge. | 2020-05-29 |
| 32468014 | Despite the very fast and large flow of scientific data on possible treatment solutions, none have yet demonstrated unequivocal clinical utility against coronavirus disease 2019 (COVID‑19). […] Drug repurposing, also known as drug repositioning, and target based methods are the most used strategies to advance therapeutic solutions into clinical practice. | 2020-05-29 |
| 32468052 | The novel hypotheses that are stemming out of these data need to be further investigated and validated in large clinical studies. | 2020-05-29 |
| 32468103 | Changes in the clinical management of the proctological disease are presented together with some considerations to be explored. […] Beside the more clinical considerations, this crisis produced unexpected consequences such as an improvement of the therapeutic alliance and a shift towards telemedicine that may be worth exploring also in the post-COVID-19 era. | 2020-06-01 |
| 32468193 | However, it is assumed that these patients are at high risk, because of respiratory symptoms and reduced lung function. | 2020-05-31 |
| 32468196 | We searched PubMed, Google Scholar and government agency websites to identify literature reporting clinical outcomes in patients taking remdesivir for COVID-19. […] In one trial, the benefit of time to clinical improvement was not statistically significant (21 vs 23 days, HR 1.23, 95% CI 0.87-1.75), although the study was underpowered. […] Preliminary clinical trial results suggest that there may be a favourable benefit-risk profile for remdesivir compared with placebo in severe COVID-19 infection and further data on benefits would strengthen this evaluation. […] Ongoing clinical trial data can be incorporated into the framework when available to provide an updated benefit-risk assessment. | 2020-05-31 |
| 32468202 | Furthermore, we analysed the clinical results of fracture patients undergoing confined or emergency surgery during the COVID-19 outbreak. […] All patients were enrolled and managed using the standardized clinical pathway we designed for preoperative COVID-19 screening. […] Clinical, laboratory and outcome data were analysed. […] We introduced a novel clinical pathway for pre-operatively screening of COVID-19 in traumatic orthopaedic patients. […] The delay in surgery caused by COVID-19 screening was minimized to a point at which reasonable and acceptable clinical outcomes were achieved. | 2020-05-31 |
| 32468230 | In this article, we report on the clinical course of two patients on biologic medication for psoriasis who developed COVID-19 and successfully recovered from SARS-CoV-2 infection. […] Both patients presented with fever and respiratory symptoms, but neither patient required hospitalization. | 2020-06-01 |
| 32468357 | Although pulmonary manifestations are more common, patients with severe disease may present with neurological symptoms such as in our case. | 2020-05-29 |
| 32468413 | What we need is more evidence-based knowledge about what routine care practices we should to apply to ameliorate symptoms of patients and fight COVID-19 pathology. | 2020-05-29 |
| 32468414 | Whilst the idea of virtual patient review may be perceived as counterintuitive to the basic foundations and principles of face-to-face clinical practice, the current global pandemic, now more than ever, highlights the importance, need and benefits of this care model. | 2020-05-29 |
| 32468425 | PubMed, Embase, ClinicalTrials.gov, ICTRP (WHO), Cochrane Library databases, and two pre-print servers (medRxiv.org and Research Square) were searched for clinical studies that evaluated the therapeutic role of HCQ on COVID-19 until 10 May 2020. […] A total of 663 articles were screened and 12 clinical studies (seven peer-reviewed and published studies and five non-peer-reviewed studies from pre-print servers) with a total sample size of 3543 patients were included. […] Some of the clinical studies demonstrated good virological and clinical outcomes with HCQ alone or in combination with azithromycin in COVID-19 patients, although the studies had major methodological limitations. […] The results of efficacy and safety of HCQ in COVID-19, as obtained from the clinical studies, are not satisfactory, although many of these studies had major methodological limitations. […] Stronger evidence from well-designed robust randomized clinical trials is required before conclusively determining the role of HCQ in the treatment of COVID-19. […] Clinical prudence is required in advocating HCQ as a therapeutic armamentarium in COVID-19. | 2020-05-31 |
| 32468508 | On March 09, 2020, at the time of protocol design, the Italian Ministry of Health reported 10,149 people who had contracted the virus; of these, 8514 were positive, of which 5038 were hospitalized with symptoms (59.2%) and 877 in intensive care (10.3%), while the remaining 2599 were in home isolation; 631 were deceased (6.2%) and 1004 healed (9.9%). […] Based upon the little existing evidence, we planned to assess the efficacy of the infusion of hyperimmune plasma in COVID-19 patients in a one-arm proof-of-concept clinical trial. […] Moreover, the results from this study, if encouraging, will allow us to plan further informed large clinical trials. | 2020-05-29 |
| 32468710 | The COVID-19 pandemic has halted many ongoing CNS clinical trials, especially in Alzheimer’s disease. […] We propose the concept of mechanistic modeling-based virtual twin patients as a possible solution to harmonize the readouts from these complex and fragmented clinical datasets in a biologically relevant way. | 2020-05-29 |
| 32468775 | Cases are clinically diagnosed based on their signs and symptoms and chest x-rays without laboratory testing. […] Respiratory symptoms, fever, cough, dyspnoea, myalgia, fatigue, breathing difficulties and bilateral lung infiltrates on C.T are common findings. | 2020-05-29 |
| 32468851 | We provided an analysis of laboratory, clinical and therapeutic data related with severe acute respiratory syndrome coronavirus. […] We finally focused on implications of immunotherapy treatments in clinical practice. | 2020-05-29 |
| 32469045 | Results of an observational assessment of operational and clinical pharmacy services at a community teaching hospital during the first weeks of the COVID-19 pandemic are presented. […] Evaluated outcomes included daily order verifications, clinical interventions, and usage of relevant medications. […] The operational and clinical requirements of an inpatient pharmacy department shifted considerably during the first weeks of the COVID-19 pandemic. | 2020-05-29 |
| 32469096 | The sudden and unanticipated COVID-19 viral pandemic of 2020 and its profound impact on the NHS prompted an almost overnight change in the services we are able to offer our patients to fulfil clinical demands. […] Our results show a patient satisfaction of 93% with 83% happy to have telephone follow-up in the future and a clinician satisfaction of 82% in adequacy of the telephone consultation in making a clinical decision. | 2020-05-29 |
| 32469137 | An efficient and convenient method based on clinical characteristics was needed to evaluate the potential deterioration in patients. […] We retrospectively investigated the clinical information of confirmed COVID-19 patients from 10 February 2020 to 29 February 2020 in Wuhan Union Hospital. […] Furthermore, three variables were used to formulate a clinical risk scoring system named COVID-19 index = 3 × D-dimer (µg/L) + 2 × lgESR (mm/hr) - 4 × lymphocyte (×109 /L) + 8. | 2020-06-13 |
| 32469164 | Here, we provide some suggestions for early identification of COVID-19 and differential diagnosis in patients with lung cancer who have fever and respiratory symptoms. […] Our medical team also provide clinical recommendations on lung cancer management during the COVID-19 pandemic, for carrying out meticulous and individualized clinical management of lung cancer patients and maximum protection to effectively prevent COVID-19. […] KEY POINTS: Significant findings of the study This article provides suggestions for early identification of COVID-19 and differential diagnosis in patients with lung cancer with fever and respiratory symptoms. […] What this study adds This article makes clinical recommendations on lung cancer management during the COVID-19 pandemic. | 2020-06-12 |
| 32469189 | Of the 400 patients planned for visits in the ACIM, 349 were consulted by phone. 299 patients confirmed stable health. 14/349 patients reported some symptoms and 4/349 patients were hospitalized; 2/349 patients changed their primary ACIM and were no longer under our care, 1/349 patient was undergoing quarantine, 15/349 patients required additional intervention and 15 patients had died prior to contact. | 2020-05-29 |
| 32469194 | The complete clinical workflow together with infectious disease ward was simulated. | 2020-05-29 |
| 32469225 | A close interaction between the virus SARS-CoV-2 and the immune system of an individual results in a diverse clinical manifestation of the COVID-19 disease. | 2020-05-29 |
| 32469255 | The article aims to highlight the appropriate strategies for combating the COVID-19 pandemic in the clinical setting and emphasize on the areas that require further investigation in relation to COVID-19 infections in patients with obesity and diabetes mellitus from the viewpoint of endocrinology and metabolism. | 2020-06-25 |
| 32469297 | Research from financial stress, disasters, pandemics and other extreme events, suggests that behavioral health will suffer, including anxiety, depression, and posttraumatic stress symptoms. […] Further these symptoms are likely to exacerbate alcohol or drug use, especially for those vulnerable to relapse. […] We propose a four-step services system designed for implementation with a variety of different groups and reserves limited clinical services for the most extreme reactions. […] While we can expect symptoms to remit overtime, many will also have longer-term or more severe concerns. | 2020-05-29 |
| 32469301 | Quinupristin is an antibiotic that has been in clinical use for two decades and is known to cause relatively minor side effects.Conclusion. Quinupristin represents a potential anti-SARS-CoV-2 therapeutic. | 2020-05-29 |
| 32469387 | This review serves to summarize available information regarding coronaviruses in the nervous system, identify the potential tissue targets and routes of entry of SARS-CoV-2 into the central nervous system, and describe the range of clinical neurological complications that have been reported thus far in COVID-19 and their potential pathogenesis. […] Recognition and understanding of the range of neurological disorders associated with COVID-19 may lead to improved clinical outcomes and better treatment algorithms. | 2020-05-29 |
| 32469437 | This literature review aims to provide a comprehensive current summary of the pathogenesis, clinical features, disease course, host immune responses, and current investigational antiviral and immunomodulatory pharmacotherapies, in order to facilitate the development of future therapies and measures for prevention and control. | 2020-05-29 |
| 32469504 | The 2019 novel coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a zoonotic disease that is dominated by pulmonary symptoms. | 2020-06-26 |
| 32469614 | One patient presented with predominantly cardiac symptoms. | 2020-05-29 |
| 32469620 | We discuss the common challenges that we faced across our respective fields ranging from basic to clinical to epidemiological women’s health research, including the impact it had on our career trajectories. | 2020-05-29 |
| 32469632 | Senior medical students at the University of Auckland, New Zealand spend most of their learning time in clinical attachments. […] Acute conversion of their general practice education from experiential clinical exposure to online and offsite learning was required. […] Learning from this experience contributes to the body of knowledge around online education, particularly in meeting the needs of a clinical attachment traditionally grounded in experiential learning. | 2020-05-29 |
| 32469732 | Demographic and clinical data were recorded. […] We stratified patients in groups according to the time interval between symptoms onset (cut-off 5 days) and X-ray imaging and according to age (cut-off 60 years old). […] Computed tomography was performed in case of a discrepancy between clinical symptoms, laboratory and X-ray findings, and/or suspicion of complications. […] Patients admitted to the emergency radiology department after 5 days from symptoms onset, more frequently had interstitial and AO opacities, in comparison to those admitted within 5 days, and lung lesions were more frequently bilateral and peripheral. | 2020-05-31 |
| 32469844 | However, it is important to emphasize that due to its wide availability, telemedicine services can provide sufficient flexibility for both primary and specialist care (outpatient and inpatient clinical care). | 2020-06-02 |
| 32469854 | Different scientific societies have published clinical practice guidelines regarding ophthalmic care in the COVID-19 pandemic, but the information is presented inconsistently, which makes decision-making difficult. […] We conducted a sensitive bibliographic search in EMBASE and ophthalmic society webpages, of the clinical practice guidelines of ophthalmic care in pandemic COVID-19. […] The clinical practice guidelines that we reviewed all recommend rescheduling all non-urgent consultations and surgeries, reinforcing contact precautions, the use of personal protection elements, and the disinfection of surfaces and instruments. | 2020-05-29 |
| 32470088 | The survey collected data on socio-demographic and clinical variables related to COVID-19 (based on the current knowledge); along with measuring psychological impact with the help of Impact of Event-revised (IES-R) scale. […] Presence of physical symptoms and contact history predicted higher psychological impact, but did not reach statistical significance. | 2020-05-29 |
| 32470144 | Before the COVID-19 pandemic, clinicians were already adept at creating workarounds for day-to-day shortages of equipment, inventively cobbling together substitute gadgets together to fulfil a clinical need. | 2020-05-29 |
| 32470148 | Patients were divided into mild-moderate and severe groups, according to respiratory impairment and clinical management. | 2020-05-29 |
| 32470151 | The wide spectrum of symptoms observed in COVID-19 appears to defy explanation. | 2020-05-29 |
| 32470156 | The presenting symptoms for PE were untypical including dyspnea, which is one of the major symptoms in severe COVID-19, especially in those patients with acute respiratory distress syndrome (ARDS). | 2020-06-12 |
| 32470162 | The coronavirus disease-2019 (COVID-19) is a viral illness with heterogenous clinical manifestations, ranging from mild symptoms to severe acute respiratory distress syndrome and shock caused by the severe acute respiratory syndrome coronavirus-2. | 2020-06-12 |
| 32470167 | Restrospective analysis of clinical data of 85 patients infected with SARS-CoV-2, including gender, age, comorbidities, symptoms, blood routine, clotting profile, biochemical examination, albumin, myocardial enzyme profile, inflammatory markers, and chest CT. […] Fever and dry cough accounted for the highest percentage of all symptoms. | 2020-06-11 |
| 32470171 | Here, we describe the necessary precautions in the form of clinical questions and answers (Q&A) regarding the safe deployment of gastrointestinal endoscopy in such situations while protecting endoscopy staff and patients from infection. | 2020-06-19 |
| 32470198 | At this juncture, we do need to consider where do the non-anticoagulant properties of heparin fit in the COVID-19 clinical context? | 2020-05-29 |
| 32470210 | Given the high prevalence of obesity in the United States, we hypothesized that the presence of obesity may play a role in the clinical course of COVID-19 patients. […] Demographics, clinical characteristics, laboratory data, and clinical outcomes were abstracted. | 2020-06-11 |
| 32470237 | This paper, based on proven effective experience, relevant guidelines, and research, not only presents the fundamental knowledge about the name, etiologic characteristics, epidemiologic characteristics and clinical manifestations of COVID-19, transmission routes and risk points of SARS-CoV-2 in dental clinics but also provides recommended protective measures for dental professionals to interdict the transmission of SARS-CoV-2 in dental clinics. […] This paper, based on proven effective experience, relevant guidelines, and research, not only presents the fundamental knowledge about the name, etiologic characteristics, epidemiologic characteristics and clinical manifestations of COVID-19, transmission routes and risk points of SARS-CoV-2 in dental clinics but also provides recommended protective measures for dental professionals to interdict the transmission of SARS-CoV-2 in dental clinics. | 2020-06-02 |
| 32470238 | To review the literature on the presence of two clinical manifestations in patients presenting COVID-19 (SARS-CoV-2) infection: loss of taste (ageusia) and loss of smell (anosmia). […] Of the 19 studies analyzed, five were included to evaluate the presence of ageusia and/or anosmia as symptoms in patients who were tested and resulted positive for the SARS-CoV-2 virus. […] Only one study recorded both symptoms with a percentage of 18.6%. […] These symptoms may be considered as the first manifestation of the infection. | 2020-06-02 |
| 32470316 | Contacts of the case-patient were identified, actively monitored for symptoms, interviewed for a detailed exposure history, and tested for SARS-CoV-2 infection by real-time reverse transcription PCR (rRT-PCR) and ELISA. | 2020-05-29 |
| 32470470 | There are over 2118 on-going clinical trials underway, but to date none of these drugs have consistently proven effective. | 2020-06-13 |
| 32470486 | Treatment with ruxolitinib plus SoC was not associated with significantly accelerated clinical improvement in severe patients with COVID-19, although ruxolitinib recipients had a numerically faster clinical improvement. […] Although no statistical difference was observed, ruxolitinib recipients had a numerically faster clinical improvement. | 2020-05-31 |
| 32470515 | RASTAVI (NCT03201185) is an ongoing randomized clinical trial randomly allocating Ramipril or control after successful transcatheter aortic valve replacement at 14 centers is Spain. | 2020-05-31 |
| 32470547 | Additional experimental and clinical studies explaining more the relationships between NEP and COVID-19 will greatly benefit in designing the future treatment approaches. | 2020-06-28 |
| 32470568 | To summarize evidence from human clinical studies for using HCQ or CQ as antiviral agents for any viral infection. […] Cochrane Clinical Trial Registry and Chinese Clinical Trials Registry for trials registered after 2015. | 2020-05-31 |
| 32470606 | To delineate the clinical characteristics of critically ill COVID-19 patients co-infected with influenza. […] In this study, we included adult patients with laboratory-confirmed COVID-19 form Tongji Hospital (Wuhan, China), with or without influenza, and compared their clinical characteristics. | 2020-06-16 |
| 32470785 | Children had mild symptoms and hardly infected other children or adults. […] The cellular immune system of children differs from that of adults may be the keystone of atypical clinical manifestations or even covert infection. | 2020-05-29 |
| 32470824 | Little is known about the mechanisms by which the virus causes central nervous system (CNS) symptoms, and therefore little guidance is available regarding potential workup or management options. […] In all four cases, a change in mental status was the presenting symptom, and three of the four cases lacked significant respiratory symptoms. | 2020-05-31 |
| 32470885 | In response, many EUA assays have become available for clinical laboratories, and more recently, the point of care device, Abbott ID NOW. | 2020-05-29 |
| 32470974 | The US Department of Veterans Affairs (VA) is using an automated short message service (SMS) application named ‘Annie’ as part of their COVID-19 response with a protocol for coronavirus precautions, which can help the Veteran monitor symptoms and can advise the Veteran when to contact their VA care team or a nurse triage line. | 2020-05-29 |
| 32471001 | Although a higher respiratory rate was observed at admission in nonsurvivors, symptoms at presentation were similar between both groups. | 2020-05-29 |
| 32471004 | COVID-19, the clinical syndrome caused by the novel coronavirus, SARS-CoV-2, continues to rapidly spread, leading to significant stressors on global healthcare infrastructure. | 2020-06-19 |
| 32471013 | Based on this limited data, liver transplant recipients appear to have a low incidence of COVID-19, with less severe symptoms than expected, when compared with the general population and other solid organ recipients. | 2020-06-19 |
| 32471066 | Due to the complexity of Covid-19 patient management, it is of paramount importance to develop a well-defined clinical workflow in order to avoid the inconsistent management of patients. […] The suggested ICP was developed by a multi-professional team composed of different specialists and administrators already involved in clinical and management processes. | 2020-05-30 |
| 32471274 | The impact of the pandemic on clinical trials can be especially profound given their complexities and operational requirements. […] The STREAM Clinical Trial is the largest trial for MDR-TB ever conducted. | 2020-05-30 |
| 32471302 | Despite the wide outbreak of the infection, a remarkable asymmetry is observed in the number of cases and in the distribution of the severity of the COVID-19 symptoms in patients with respect to the countries/regions. | 2020-05-30 |
| 32471311 | The current novel coronavirus, COVID-19, has reduced face-to-face contact, and this has challenged how health professionals and clinical students can access training, accreditation and development. | 2020-05-30 |
| 32471607 | According to previous reports, diabetes seems to be a risk factor which worsens the serious clinical events caused by COVID-19. | 2020-05-30 |
| 32471628 | Every transplant program is unique, and an individualized plan to adapt and modify standard clinical practices will be required to continue providing essential transplantation services. | 2020-05-30 |
| 32471650 | We report on clinical and biochemical features of these patients. […] Clinical presentation of pulmonary embolism patients was usually characterized by persistence or worsening of respiratory symptoms, with increasing oxygen requirement. […] Six out of 7 patients were treated with unfractionated or low molecular weight heparin with clinical benefit within few days; one patient needed systemic thrombolysis (death from hemorrhagic complication). | 2020-05-30 |
| 32471782 | Emergency physicians must maintain a high clinical suspicion for this COVID-19 associated post-infectious cytokine release syndrome, with features that overlap with Kawasaki Disease (KD) and Toxic Shock Syndrome (TSS) in children with recent or current COVID-19 infection, as patients can decompensate quickly. | 2020-05-30 |
| 32471783 | Patients infected with the SARS-CoV-2 virus can present with a wide variety of symptoms including being entirely asymptomatic. […] Despite having no or minimal symptoms, some patients may have markedly reduced pulse oximetry readings. […] We present a case of a 72-year-old male with COVID-19 syndrome who presented to the emergency department with minimal symptoms but low peripheral oxygen saturation readings. | 2020-05-30 |
| 32471794 | In both cases, lower respiratory tract symptoms were observed first, and high fever progressed in about one week. […] In the domestic endemic situation, a comprehensive evaluation of the clinical course, and laboratory and radiological findings was required for diagnosis. | 2020-05-30 |
| 32471884 | To characterize patients with coronavirus disease 2019 (covid-19) in a large New York City medical center and describe their clinical course across the emergency department, hospital wards, and intensive care units. […] Characterization of patients, including demographics, presenting symptoms, comorbidities on presentation, hospital course, time to intubation, complications, mortality, and disposition. […] The most common presenting symptoms were cough (732/1000), fever (728/1000), and dyspnea (631/1000). | 2020-05-30 |
| 32471894 | The recent emergence of the SARS-CoV-2 pandemic has posed formidable challenges for clinical laboratories seeking reliable laboratory diagnostic confirmation. | 2020-05-30 |
| 32471903 | The aim was to examine demographic and clinical factors associated with COVID-19 hospitalisation status in people with rheumatic disease. | 2020-05-30 |
| 32472138 | Clinical course and outcomes were similar to those reported in other hospitalized cohorts. | 2020-05-30 |
| 32472191 | Age- and sex-adjusted multivariable logistic regressions were performed to assess the prognostic value of clinical and biological features with the endpoint. | 2020-05-30 |
| 32472325 | This commentary details an Australian hospital pharmacy response to the COVID-19 pandemic, describing the unique clinical and practical contributions made by a specialized COVID pharmacist in our institution. | 2020-05-30 |
| 32472403 | The safety of minimally invasive procedures during COVID pandemic remains hotly debated, especially in a country, like Italy, where minimally invasive techniques have progressively and pervasively entered clinical practice, in both the hepatobiliary and pancreatic community. | 2020-05-30 |
| 32472408 | Delivery of health care to other populations including cancer patients has been significantly disrupted. […] The effects on surgical oncology training, research and clinical trials are major. | 2020-05-30 |
| 32472454 | A questionnaire was sent to all five ITCC-accredited Spanish Paediatric Oncology Early Phase Clinical Trial Units, including questions about impact on staff activities, recruitment, patient care, supply of investigational products, and legal aspects. […] The COVID-19 crisis has significantly impacted clinical research practice and access to innovation for children with cancer. | 2020-05-30 |
| 32472459 | In these patients, clinical signs and symptoms, as well as laboratory abnormalities, suggest a cytokine storm syndrome in response to the viral infection. […] We reviewed the literature, combining it with our experiences and our specialist knowledge, to propose a management algorithm, correlating the clinical features with laboratory and imaging findings to establish the right timing for each treatment.Key Points• Critically ill COVID-19 patients show signs of cytokine storm syndrome. | 2020-05-30 |
| 32472464 | Taxis can be safely attempted early after the onset of symptoms and is effective in about 70% of patients. | 2020-05-30 |
| 32472516 | Our clinical evaluation was consistent with an involvement of the brainstem and especially of respiratory centre thus possibly explaining the weaning failure in patients that were awake and had recovered from lung involvement. | 2020-05-30 |
| 32472653 | Cell therapy with mesenchymal stromal cells (MSCs) is a potential treatment for COVID-19 ARDS based on preclinical and clinical studies supporting the concept that MSCs modulate the inflammatory and remodeling processes and restore alveolo-capillary barriers. | 2020-05-30 |
| 32472655 | Among these cytokines, IL-6 plays a key role in cytokine storm and can predict the adverse clinical outcomes and fatality in these patients. […] Therefore, parthenolide may be one of the herbal candidates for clinical evaluation. | 2020-05-30 |
| 32472679 | Besides clinical scoring, hamster specimens were tested for viral load, histopathology, and viral nucleocapsid antigen expression. […] Unlike the severe COVID-19 manifestations of challenged hamsters, infected naïve hamsters had lower clinical scores, milder histopathological changes, and lower viral nucleocapsid antigen expression in respiratory tract tissues. | 2020-05-30 |
| 32472683 | Although RNA has been detected in various clinical samples, no reports to date have documented SARS-CoV-2 in human milk. | 2020-05-30 |
| 32472687 | After various public health interventions including enforced public education on hand hygiene, cough etiquette and staying at home with respiratory symptoms, universal mask use in public places, refrain from non-essential social activities and school closure, the duration of the influenza epidemic in 2019/2020 decreased by 6-12 weeks and the influenza activity peak rated 49.8 ILI/1,000 visits compared to 71.9-86.2 ILI/1,000 visits of previous seasons. | 2020-05-30 |
| 32472703 | We describe a clinical series of eight patients treated with Sarilumab an IL-6R inhibitor administered early in Covid-19 pneumonia. | 2020-05-30 |
| 32472706 | We report a review of all the experimental and clinical studies performed in the last 60 years on the antiviral activity of inactivated Corynebacterium Parvum (Cutibacterium acnes). […] This bacterium has been originally investigated and used for its oncolytic properties linked to immunomodulating activity, but the interest to successfully prevent and treat bacterial, fungal and viral infections and lethality, uprising the innate immunity barriers produced many experimental models and very few clinical studies. | 2020-05-30 |
| 32472745 | To address the myriad issues generated by this pandemic, an interdisciplinary breadth of research, clinical and public health communities has rapidly engaged to collectively find answers and solutions. | 2020-05-30 |
| 32472773 | Unlike the closed system that characterizes an intubated patient attached to a respiratory circuit, non-invasive ventilatory support threatens an increased risk of permeating the clinical workspace with airborne viral particles. | 2020-05-30 |
| 32472897 | The main symptoms of COVID-19 are fever, fatigue, dry cough; however, myalgia and dyspnea and the transmission routes include direct transmission by cough, sneeze, droplet inhalation, or contact transmission with the oral, nasal, or eye mucous membranes. […] OMFS should be able to identify a suspected case of COVID-19, its symptoms, risk groups, disease severity, laboratorial and computed tomography alterations, and treatment guidelines. | 2020-05-30 |
| 32472990 | The current paper is a review of the most recent literature regarding SARS-CoV-2 infection and its associated main cardiovascular clinical manifestations. | 2020-05-30 |
| 32472991 | We summarize what makes SARS-CoV2 different from previous highly pathogenic coronaviruses and why it is so contagious, with focus on its clinical presentation and diagnosis, which is mandatory to start the appropriate management and reduce the transmission. […] Clinical management involves the intensive care approach with intubation and mechanical ventilation in the most serious cases and drug therapy with several apparently promising old and new molecules. | 2020-05-30 |
| 32473029 | These may sound like the clinical presentation of COVID-19, but Nay! […] These are the symptoms experienced by the countless health professions education (HPE) teachers who have suddenly been thrust into the online world to engage learners. | 2020-05-30 |
| 32473085 | The emergent presentation with limited clinical information led to exposure of personnel. […] The diagnosis was complicated by two negative tests for SARS-COV-2, and high-clinical suspicion from the patient’s occupational history led to additional testing in order to confirm the diagnosis. | 2020-05-30 |
| 32473108 | We created a tiered priority system to reschedule patients for whom imaging could be delayed with minimal clinical impact. | 2020-05-30 |
| 32473109 | The primary study outcome was safety, and the secondary outcome was clinical status at day 14 post-transfusion. […] Clinical improvement was assessed based on a modified World Health Organization 6-point ordinal scale and laboratory parameters. […] At day 7 post-transfusion with convalescent plasma, nine patients had at least a 1-point improvement in clinical scale, and seven of those were discharged. […] By day 14 post-transfusion, 19 (76%) patients had at least a 1-point improvement in clinical status and 11 were discharged. | 2020-05-30 |
| 32473197 | The evolving ethical and clinical environment requires reappraisal of perioperative factors such as personal protective equipment conservation; limiting the risk of exposure to COVID-19 for patients, families, and health care workers; preservation of hospital beds and intensive care unit resources; and minimizing COVID-19 related perioperative risk to patients. | 2020-05-30 |
| 32473310 | However, their clinical use may be limited by anti-SARS-CoV-2 50% maximal effective concentrations (EC50) that exceeded their achievable peak serum concentrations (Cmax), side effects, and/or availability. | 2020-05-30 |
| 32473390 | In this review, epidemic outbreak, clinical findings, prevention recommendations of COVID-19 and suggestive medicinal value of south Indian plant sources has been discussed. […] In future its required to provide medicinal plant based clinical products (Masks, sanitizers, soap etc.) with better techniques by clinicians to contend the scarcity and expose towards the nature based medicine rather than chemical drugs. […] This could be a benchmark for the economical clinical trials of specific plant material to treat the viral diseases. | 2020-05-30 |
| 32473418 | If signs suggestive of infection (coronavirus or other) occurs, treatments should be discontinued and resumed, if necessary, after 2 weeks without any symptoms. | 2020-05-30 |
| 32473600 | In a case series of patients with bilateral COVID-19 pneumonia, baricitinib treatment was associated with clinical and radiologic recovery, a rapid decline in SARS-CoV-2 viral load, inflammatory markers, and IL-6 levels. | 2020-05-30 |
| 32473603 | Common symptoms of COVID-19 include cough, myalgia, fever, chest pain, and headache. […] However, its clinical presentation ranges from completely asymptomatic to acute respiratory distress syndrome.[ | 2020-05-30 |
| 32473607 | Prevalence of liver injury and associated clinical characteristics are not well-defined. […] Patients with severe liver injury had a more severe clinical course, including higher rates of ICU admission (69%), intubation (65%), renal replacement therapy (33%), and mortality (42%). | 2020-05-30 |
| 32473657 | Information about incidence, clinical characteristics, and outcomes of HIV-infected individuals with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is scarce. […] Clinical, analytical, and radiological presentation of COVID-19 in HIV-infected individuals was similar to that described in the general population. […] SARS-CoV-2 RT-PCR remained positive after a median of 40 days from symptoms onset in six (32%) individuals, four of whom had severe disease or low nadir CD4 cell counts. | 2020-06-03 |
| 32473681 | We collected data on baseline clinical conditions, medications, cancer diagnosis and treatment, and COVID-19 disease course. | 2020-06-23 |
| 32473682 | We aimed to describe the clinical and demographic characteristics and COVID-19 outcomes in patients with cancer. […] The UKCCMP is the first COVID-19 clinical registry that enables near real-time reports to frontline doctors about the effects of COVID-19 on patients with cancer. […] We excluded patients with a radiological or clinical diagnosis of COVID-19, without a positive RT-PCR test. | 2020-06-23 |
| 32473812 | The results of the first clinical studies evaluating the effect of hydroxychloroquine do not support any efficacy of this drug in patients with COVID-19, due to major methodological weaknesses. […] In the absence of evidence of clinical benefits, the main risk is of exposing patients unnecessarily to the well-known adverse effects of hydroxychloroquine, with a possibly increased risk in the specific setting of COVID-19. […] In addition, widespread use outside of any recommendation risks compromising the completion of good quality clinical trials. | 2020-06-04 |
| 32473952 | The duration of quarantine required after clinical recovery to definitively prevent transmission is therefore uncertain. […] In addition, asymptomatic and presymptomatic transmission may occur, and infectivity may be highest early after onset of symptoms, meaning that contact tracing, isolation of exposed individuals and social distancing are essential public health measures to prevent further spread. | 2020-06-22 |
| 32473953 | Sensitivity 14-25 days after the onset of symptoms was between ≥92.1% (78.5-98.0) and 100% (95.7-100) for IgG LFA compared to 89.5% (75.3-96.4) for IgG ELISA. […] Sensitivity for the detection of IgG antibodies 14-25 days after the onset of symptoms was ≥92.1% for all seven LFAs compared to 89.5% for the IgG ELISA. | 2020-06-13 |
| 32473964 | However, further studies are still needed to assess the benefits of such a strategy on clinical outcomes. | 2020-06-13 |
| 32474026 | A number of medications have been proposed and there are ongoing clinical trials around the world to find a suitable treatment. […] This article points out some of those important lessons with some suggestions for future clinical trials. | 2020-06-05 |
| 32474043 | We aimed to measure the effect of ACEIs and/or ARBs on COVID-19 severe clinical illness by a meta-analysis. | 2020-06-07 |
| 32474064 | Thus, this study not only presents a new methodology for detecting the pathophysiologic role of NETs but also lays down a foundation for exploring therapeutic interventions in an effort to cure ALI/ARDS in the clinical setting of severe pneumonia, including the emerging of NCIP. | 2020-06-25 |
| 32474087 | Little is still known about the clinical features associated with the occurrence of acute respiratory distress syndrome (ARDS) in hospitalized patients with Coronavirus disease 2019 (COVID-19). […] The aim of the present study was to describe the prevalence of pre-admission antithrombotic therapies in patients with COVID-19 and to investigate the potential association between antithrombotic therapy and ARDS, as disease clinical presentation, or in-hospital mortality. | 2020-06-28 |
| 32474092 | Patients were grouped into 1 of 3 categories according to imaging and clinical features; encephalopathy, acute necrotizing encephalopathy, and vasculopathy. | 2020-06-28 |
| 32474093 | Since December 2019, when the virus was identified in humans, the literature on COVID-19 has grown exponentially and extrarespiratory symptoms including neurologic symptoms are increasingly highlighted. […] These neurologic disorders are grouped into several categories, ranging from nonspecific and moderate symptoms such as headache, myalgia, and hyposmia to severe symptoms including cerebrovascular disease and intracranial infections. […] Severe neurologic symptoms such as acute cerebrovascular disease occur only in a minority of patients with usual risk factors and are associated with poor outcome. […] However, most COVID-19 patients exhibit only minor or mild neurologic symptoms. […] Management of COVID-19 patients should include early clinical, radiologic, and laboratory neurologic assessment, with a close follow-up, especially in severe forms. | 2020-06-26 |
| 32474126 | We will discuss how clinical physics has transformed to ascertain safety and quality standards across four facilities around the world through diversity of action, innovation, and scientific flexibility. | 2020-06-26 |
| 32474129 | Within our department, a multidisciplinary tracer team prospectively monitored all patients under investigation, tracking their test status, treatment delays, clinical outcomes, employee exposures, and quarantines. | 2020-06-26 |
| 32474280 | WBE measures chemical signatures in sewage, such as fragment biomarkers from the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), simply by applying the type of clinical diagnostic testing (designed for individuals) to the collective signature of entire communities. | 2020-06-24 |
| 32474371 | A laboratory workflow twinning research environment with clinical laboratory capabilities was implemented and validated in the University of Birmingham within 4 days of the project initiation. […] RNA was detected in 54 % of those who reported symptoms compatible with COVID-19, but in only 4% who were asymptomatic. […] This capability was established rapidly and utilised a cold-chain free methodology, applicable to a wide range of settings, and which can provide surge capacity and support to clinical laboratories facing increasing pressure during periods of national crisis. | 2020-06-18 |
| 32474381 | Since the outbreak of Coronavirus Disease 2019 (COVID-19), loss of smell has increasingly been reported as a frequent clinical sign. | 2020-06-16 |
| 32474399 | Though major symptoms are primarily generated from the respiratory system, neurological symptoms are being reported in some of the confirmed cases, raising concerns of its potential for intracranial invasion and neurological manifestations, both in the acute phase and in the long-term. | 2020-06-28 |
| 32474476 | However, there are limited and uncertain clinical data to support the beneficial effect of this drug in COVID-19 treatment. | 2020-05-31 |
| 32474479 | To analyze clinical and thin-section computed tomographic (CT) data from the patients with coronavirus disease (COVID-19) to predict the development of pulmonary fibrosis after hospital discharge. | 2020-06-19 |
| 32474523 | The ablation expert committee of the Chinese Society of Clinical Oncology compiled corresponding expert recommendations. | 2020-06-04 |
| 32474561 | The aim of this study was to analyze and summarize the clinical characteristics of elderly patients with coronavirus disease 2019 (COVID-19) and compare the differences of young-old patients (60-74 years old) and old-old patients (≥75 years old). […] In thisretrospective, multicenter study, the medical records of elderly patients who were diagnosed with COVID-19 in Hunan province, China, from January 21 to February 19, 2020 were reviewed. […] On admission, the most frequent symptoms in elderly patients included fever (66.7%), cough (64.8%), and fatigue (33.3%). […] They could show atypical symptoms without fever or cough and multiple organ dysfunction. | 2020-05-31 |
| 32474598 | Here, we identify risk factors and propose a clinical score to predict COVID-19 lethality, including specific factors for diabetes and obesity and its role in improving risk prediction. […] Finally, we built a clinical score to predict COVID-19 lethality. […] Our score offers a clinical tool for quick determination of high-risk susceptibility patients in a first contact scenario. | 2020-06-26 |
| 32474608 | Clinical data were collected and compared between patients with short and long viral RNA shedding (in the first and last quarter). | 2020-05-31 |
| 32474629 | To compare clinical, laboratory, and chest computed tomography (CT) findings in critically ill patients diagnosed with coronavirus disease 2019 (COVID-19) who survived and who died. […] This retrospective study reviewed 60 critically ill patients (43 males and 17 females, mean age 64.4 ± 11.0 years) with COVID-19 pneumonia who were admitted to two different clinical centers. […] Their clinical and medical records were analyzed, and the chest CT images were assessed to determine the involvement of lobes and the distribution of lesions in the lungs between the patients who recovered from the illness and those who died. | 2020-06-03 |
| 32474630 | • Chest radiography showed lung abnormalities in 75% of patients with confirmed SARS-CoV-2 infection, range varied from 63.3 to 83.9%, respectively, at 0-2 days and > 9 days from the onset of symptoms. | 2020-06-03 |
| 32474631 | To investigate whether meaningful subgroups sharing the CT features of patients with COVID-19 pneumonia could be identified using latent class analysis (LCA) and explore the relationship between the LCA-derived subgroups and clinical types. […] Univariate and multivariate logistic regression models were utilized to analyze the association between clinical types and the LCA-derived subgroups. […] The demographic and clinical differences between the two radiological subgroups based on the LCA were significantly different. […] Two radiological subgroups were significantly associated with clinical moderate and severe types. | 2020-06-03 |
| 32474718 | Scheduled clinical appointments decreased by ~ 22%. […] Telemedicine was used in 90% of outpatient clinical evaluations. | 2020-06-03 |
| 32474757 | This clinical entity seems to be associated with a marked hypercoagulable state that causes both arterial and venous thromboembolic complications. […] Although rapidly worsening respiratory symptoms in a patient with SARS-CoV-2 respiratory infection may correlate with worsening pneumonia itself, it may also mask a pulmonary embolism. | 2020-06-19 |
| 32474850 | Clinical features of COVID-19 have been mostly described in hospitalized patients with and without ICU admission. […] In France, health authorities recommend outpatient management of patients presenting mild-to-moderate COVID-19 symptoms. […] The aim of this study was to describe their clinical characteristics. […] We investigated clinical features and classified symptoms as general, digestive, ear-nose-throat, thoracic symptoms, and eye disease. […] In addition to dry cough and fever reported in more than 90% of cases, the most common symptoms were general symptoms: body aches/myalgia (N = 845; 57%), headache (N = 824; 55%), and asthenia (N = 886; 60%); shortness of breath (N = 479; 32%) and ear-nose-throat symptoms such as anosmia (N = 415; 28%) and ageusia (N = 422; 28%). […] The main difference between male and female patients was an increased prevalence of ear-nose-throat symptoms as well as diarrhea, chest pains, and headaches in female patients. […] General symptoms and ear-nose-throat symptoms were predominant in COVID-19 patients presenting mild-to-moderate symptoms. | 2020-06-03 |
| 32474860 | On the basis of clinical practice and in-vitro studies, we postulated that post-exposure prophylaxis (PEP) using Arbidol is associated with decreased infection among individuals exposed to confirmed cases of COVID-19 infection. […] The emergence of fever and/or respiratory symptoms after exposure to the primary case was collected. | 2020-06-03 |
| 32474883 | Multivariate analysis showed the recommendation score was dependent on beliefs about social distancing, perceptions about clinical examination, and the satisfaction score of the first teleconsultation. | 2020-06-03 |
| 32474885 | COVID-19 infection has a heterogenous disease course; it may be asymptomatic or causes only mild symptoms in the majority of the cases, while immunologic complications such as macrophage activation syndrome also known as secondary hemophagocytic lymphohistiocytosis, resulting in cytokine storm syndrome and acute respiratory distress syndrome, may also occur in some patients. | 2020-06-24 |
| 32474891 | The co-infection has the potential to worsen clinical condition and increase mortality in these patients, as well as to prolong and increase the costs of hospitalization. | 2020-06-03 |
| 32474910 | Concerns about risk of exposure to COVID-19, combined with quarantine measures adopted during the COVID-19 pandemic, adversely affected the thoughts and emotions of new mothers, worsening depressive symptoms. | 2020-06-16 |
| 32474941 | It is thus imperative that sleep considerations be part of research and clinical initiatives aimed at understanding and mitigating the impact of the COVID-19 pandemic in children and adolescents. […] This article considers ways in which the pandemic may impact sleep, including research and clinical implications. | 2020-06-19 |
| 32474947 | Following informed consent, patients underwent: (i) clinical evaluation, (ii) RT-PCR and serology testing for SARS-CoV-2, (iii) digital videocapillaroscopy of finger- and toe-nailfolds, (iv) blood testing to screen for autoimmune diseases and coagulation anomalies, and (v) skin biopsy for histopathology, direct immunofluorescence, and, in selected cases, electron microscopy. […] Nineteen patients, all adolescents (mean age: 14 years), were recruited. 11/19 (58%) of them and/or their cohabitants reported flu-like symptoms one to two months prior to skin manifestation onset. […] Chilblain-like lesions during COVID-19 pandemic have specific epidemiologic, clinical, capillaroscopic and histopathological characteristics, which distinguish them from idiopathic perniosis. | 2020-06-19 |
| 32475003 | A new type of coronavirus family (SARS-CoV-2), which can be found in humans and animals, with many varieties and clinical symptoms, was first seen in Wuhan, China in late 2019, under the name novel Coronavirus Disease 2019 (COVID-19). […] In the literature, cutaneous symptoms related to the disease are generally emphasized. | 2020-06-19 |
| 32475006 | A review of the PubMed database was carried out, describing taxonomy, classification, virology, genetic recombination, host adaptation, and main symptoms related to each type of virus. | 2020-06-26 |
| 32475012 | With the rapid adoption of these tests into clinical practice, combined with the widespread publicity they received, questions arose related to the different types of tests, their utility, performance, and regulatory approval status. | 2020-06-19 |
| 32475019 | FPV trough concentration in critically ill patients was much lower than that of healthy subjects in a previous clinical trial, which is a cause for great concern. | 2020-06-19 |
| 32475035 | The value of these articles and their impact on clinical impact were discussed and we hope that dermatologists can have a better understanding of these areas from this study. | 2020-06-19 |
| 32475036 | Apremilast is a recently approved drug, belonging to the small molecule phosphodiesterase 4 inhibitors, whose optimal safety and efficacy profile is somewhat affected by slow activity rate in clinical trials. | 2020-06-24 |
| 32475054 | We report two cases of early liver transplant recipients infected by SARS-CoV-2 with only mild clinical manifestations. | 2020-06-19 |
| 32475104 | The common symptoms of COVID-19 are fever, cough, fatigue, and shortness of breath. | 2020-06-01 |
| 32475144 | This article described the evolution of the outbreak, and the known properties of the novel virus, SARS-CoV-2 and the clinical disease it causes, and the major public health measures being used to help control it’s spread. […] However, a number of important properties of the virus are still not well understood, and there is an urgent need to learn more about its transmission dynamics, its spectrum of clinical severity, its wildlife origin, and its genetic stability. | 2020-06-01 |
| 32475183 | Lopinavir in combination with ritonavir is approved for the treatment of HIV and has recently been subject to a clinical trial in severe COVID-19. […] After LOTUS China, there is probably no future for lopinavir in the treatment of severe COVID-19, but some clinical trials for prevention or in various stages of COVID-19 have recently started or are ongoing. | 2020-06-12 |
| 32475230 | All patients were classified into moderate, severe and critical groups according to their symptoms. 45 control samples of healthy volunteers were also included. | 2020-06-02 |
| 32475347 | The assay is in clinical use to monitor levels of HCQ in patients. | 2020-06-12 |
| 32475693 | Currently, mental health workers are facing multiple clinical situations such as forced drug and substance withdrawal (linked to difficulties in supplying psychoactive substances), symptoms of anxiety (due to concerns for their own and their relatives’ well-being) and decompensation among patients with severe psychiatric conditions. | 2020-06-05 |
| 32475747 | We found a potentially dangerous overlap of classical urinary symptoms and the as yet not fully described symptoms of COVID-19. […] We propose consideration of urinary frequency as an anamnestic tool in patients with infective symptoms to increase awareness among urologists during the current COVID-19 pandemic to prevent fatal implications of misinterpreting urological symptoms. | 2020-06-04 |
| 32475810 | We review different biomarkers to evaluate if they are able to predict clinical outcomes and correlate with the severity of COVID-19 disease. | 2020-06-17 |
| 32475827 | The COVID-19 pandemic has resulted in significant clinical and economic consequences for medical practices of all specialties across the nation. […] Although the clinical implications are of the utmost importance, the economic consequences have also been serious and resulted in substantial damage to the US healthcare system, including pain practices. […] Outpatient pain practices have had to significantly change their clinical care pathways, including the incorporation of telemedicine. […] This review article will provide insight into solutions to mitigate the clinical and economic challenges induced by COVID-19. […] In order to survive, medical practices will need dynamic, operational, and creative strategic plans to mitigate the disruption in medical care and pathways for successful reintegration of clinical and surgical practice. | 2020-06-01 |
| 32475841 | In all, 98% surveyed doctors continued to provide clinical services during the survey period, but reduced clinic service demands were observed in 45% private practices and 24% public clinics. | 2020-06-22 |
| 32475877 | All epidemiological, clinical and laboratory information was collected. | 2020-06-01 |
| 32475880 | This study aims to investigate blood and biochemical laboratory findings in patients with severe Corona Virus Disease 2019 (COVID-19) and to develop a joint predictor for predicting the likelihood of severe COVID-19 and its adverse clinical outcomes, to provide more information for treatment. | 2020-06-01 |
| 32475884 | COOPERA asked participants questions regarding personal information, preventive actions, and non-specific symptoms related to COVID-19 and their duration. […] No symptoms were reported by 96.93% of participants, but there was a significantly positive correlation between the reported number of COVID-19 cases and self-reported fevers, suggesting that massive monitoring of fever might help to estimate the scale of the COVID-19 epidemic in real time.ConclusionsCOOPERA is the first real-time system being used to monitor trends in COVID-19 in Japan, and provides useful insights to assist political decisions to tackle the epidemic. | 2020-06-01 |
| 32476080 | Routinely recorded, clinical data, up to the 24th of April 2020, from the 2075 patients with Covid-19, admitted in 17 hospitals in Spain between the 1st of March and the 20th of April 2020 were used. | 2020-06-04 |
| 32476126 | Using PubMed, Embase and Medline, articles published between January and April 2020 on Coronavirus disease 2019 (COVID-19), and resources from World Health Organisation were analyzed in order to have an understanding of the clinical characteristics, transmission dynamics, virology, diagnostic possibilities, prevention, management approach, controversies and impact of COVID-19 on the healthcare workforce. […] Our review revealed that COVID-19 patients present with a myriad of symptoms, ranging from mild to severe respiratory disease, which can often be fatal. | 2020-06-03 |
| 32476175 | The current COVID-19 pandemic has created a global context likely to increase eating disorder (ED) risk and symptoms, decrease factors that protect against EDs, and exacerbate barriers to care. […] One, the disruptions to daily routines and constraints to outdoor activities may increase weight and shape concerns, and negatively impact eating, exercise, and sleeping patterns, which may in turn increase ED risk and symptoms. […] Relatedly, the pandemic and accompanying social restrictions may deprive individuals of social support and adaptive coping strategies, thereby potentially elevating ED risk and symptoms by removing protective factors. […] Two, increased exposure to ED-specific or anxiety-provoking media, as well as increased reliance on video conferencing, may increase ED risk and symptoms. […] Three, fears of contagion may increase ED symptoms specifically related to health concerns, or by the pursuit of restrictive diets focused on increasing immunity. | 2020-06-19 |
| 32476204 | For the EARs NOSE AND THROAT (ENT) surgeon, there are many challenges that show-up in the clinical management of a patient affected by a head and neck cancer during COVID-19 pandemic, especially in the postoperative period. […] We reported several clinical data about the hospitalization period, pointing out the difficulties encountered both from clinical and management point of view. […] The changes in the whole health care system during the COVID-19 pandemic have impacted the management of patients with head and neck cancer, generating several clinical challenges for the ENT surgeon. | 2020-06-19 |
| 32476233 | Available guidelines recommend to reorganize transplant care but data on clinical experience in the context of SARS-CoV-2 pandemic are scarce. | 2020-06-19 |
| 32476258 | The clinical features, disease course, and serologic response of COVID-19 among immunosuppressed patients such as solid organ transplant (SOT) recipients, who are at presumed risk for more severe disease, are not well characterized. […] We describe our institutional experience with COVID-19 among ten SOT patients, including the clinical presentation, treatment modalities, and outcomes of seven renal transplant recipients, one liver transplant recipient, one heart transplant recipient, and one lung transplant recipient. | 2020-06-19 |
| 32476261 | There is emerging data depicting the clinical presentation of COVID-19 in solid organ transplant recipients but negligible data-driven guidance on clinical management. […] We present the clinical course of five SOT/CTTRs with SARS-CoV-2-related ARDS that received tocilizumab with favorable short-term outcomes in four. […] We discuss safety concerns and the need for randomized comparative trials to delineate tocilizumab’s clinical utility in this population. | 2020-06-19 |
| 32476285 | The process included a Laboratory Medicine designee for communication with organ recovery and transplant clinical staff, specialized sample labeling and handoff, and priority processing. | 2020-06-23 |
| 32476306 | Anosmia and ageusia are one of the common acute neurologic symptoms, which develop in the early stage of COVID-19. […] However, it is not reported that how immunosuppressive agents affect these symptoms. | 2020-06-09 |
| 32476308 | Therefore, effective countermeasures should be developed based on the already obtained clinical and research information about SARS-CoV-2. | 2020-06-01 |
| 32476380 | These clinical signs are mediated by pro-inflammatory cytokines. […] In light of the above, it is therefore pertinent to think that by blocking pro-inflammatory cytokines with new anti-inflammatory cytokines, such as IL-37 and IL-38, it is possible to alleviate the symptoms of the disease and have a new available therapeutic tool. | 2020-06-09 |
| 32476394 | In this regard, early diagnosis, including on the basis of symptoms from ENT organs, is crucial. […] However, it is in children in the epidemic aspect that early diagnosis of infection and understanding of its key symptoms is of utmost importance. | 2020-06-05 |
| 32476472 | In COVID-19, such imbalance could play an important role in influencing the clinical picture and outcome of the disease. | 2020-06-01 |
| 32476594 | The uncontrolled release of cytokines is seen from the primary stages of symptoms to last acute respiratory distress syndrome (ARDS). | 2020-06-12 |
| 32476607 | Results were analysed in combination with sera collection date and clinical information. | 2020-06-02 |
| 32476644 | This include changes to resource allocation, clinical care, and the consent process during a pandemic. | 2020-06-03 |
| 32476796 | The most common GI symptoms reported are diarrhea, nausea, vomiting, and abdominal discomfort. | 2020-06-08 |
| 32477419 | The complexity related to the new coronavirus and the clinical syndrome it causes is not yet fully understood. […] Observations reveal that immunosuppressive therapy may have a role in the treatment of this virus, placing emphasis on the scenario of safety through maintenance of therapy with biologic agents, especially when there are no signs or symptoms related to the infection or contact with an infected patient. | 2020-06-04 |
| 32477912 | It is very important for the preview and triage personnel to accurately grasp the epidemiology of the virus and identify children’s symptoms in the fever clinic. | 2020-06-04 |
| 32478289 | Here, we reveal sequences of the virus isolated from three different patients with various clinical presentations. | 2020-06-04 |
| 32478302 | To study the clinical, laboratory, and radiological characteristics of the pediatric patients infected with the new emerging 2019 coronavirus virus (SARS-CoV-2) in Hamadan and Sanandaj, west of Iran. […] Medical records of the children diagnosed as probable or confirmed cases of COVID-19 disease were extracted and analyzed in this study. […] The most common symptoms were fever, cough, and dyspnea, and the most common sign was tachypnea. […] The superimposed bacterial infection seems not the determinant of clinical outcomes as most patients had a negative evaluation by specific laboratory tests for bacterial infections; got improved dramatically with a short or no antibiotic therapy. | 2020-06-04 |
| 32478445 | One normal and 7 abnormal LUS cases indicate the impact of routine LUS on the clinical outcome and treatment of pregnant women. | 2020-06-19 |
| 32478465 | Several clinical studies have shown very good effects of TCZ in patients with COVID-19, with a few minor side effects reported. […] Nevertheless, TCZ had a positive effect on clinical and laboratory parameters in cytokine storm, with transaminases values normalizing in 10 days. | 2020-06-11 |
| 32478538 | The present commentary describes the main care services implemented by the clinical psychology unit of an Italian hospital to cope with the COVID-19 emergency outbreak. | 2020-06-04 |
| 32478543 | Researchers have long examined grief-related reactions to the diagnosis of a loved one with a terminal illness, including preloss grief (PLG), which is the experience of grief symptoms prior to the loss of a loved one. | 2020-06-04 |
| 32478557 | The current COVID-19 pandemic places maternity staff at risk of engaging in clinical practice that may be in direct contravention with evidence; professional recommendations; or, more profoundly, deeply held ethical or moral beliefs and values, as services attempt to control the risk of cross-infection. | 2020-06-04 |
| 32478559 | A higher level of vicarious trauma was associated with younger age, less clinical experience, and negative online treatment experiences. | 2020-06-04 |
| 32478706 | The main characteristics and challenging symptoms of COVID-19, caused by the novel coronavirus SARS-CoV-2, are related to re-spiratory distress. […] Although most patients have mild symptoms such as fever, headache, cough, myalgia and anosmia, some develop acute respiratory distress syndrome, leading to death in many cases. | 2020-06-09 |
| 32478951 | To examine the impact of COVID-19 on acute heart failure (AHF) hospitalization rates, clinical characteristics and management of patients admitted to a tertiary Heart Failure Unit in London during the peak of the pandemic. […] Furthermore, we performed detailed comparison of patients hospitalized during the COVID-19 pandemic and patients presenting in the same period in 2019 with respect to clinical characteristics and management during the index admission. […] Patients admitted during the COVID-19 pandemic had higher rates of NYHA III or IV symptoms (96% vs. 77%, p=0.03) and severe peripheral oedema (39% vs. 14%, p=0.01). […] We did not observe any differences in inpatient management, including place of care and pharmacological management of heart failure with reduced ejection fraction (HFrEF) CONCLUSION: Incident AHF hospitalization significantly declined in our centre during the COVID-19 pandemic, but hospitalized patients had more severe symptoms at admission. | 2020-06-19 |
| 32478961 | Of these, 27% avoided the hospital due to fear of COVID-19, 18% believed symptoms were COVID-19 related, and 9% did not want to burden the hospital during the pandemic. […] Patients’ fear and confusion about symptoms are integral parts of this emerging public health crisis. | 2020-06-19 |
| 32478971 | Although the risk for severe upper airway tract infections during clinical controlled trials was mostly in the range of placebo, these data have been obtained before the COVID-19 pandemic and should be interpreted with caution. | 2020-06-19 |
| 32479246 | Given the previous preclinical and clinical studies, MSCs therapy has been shown safety and efficacy in the treatment of respiratory failure or ARDS. […] In this study, we summarized the clinical outcomes of MSCs for ARDS patients in some preclinical and clinical studies, and discussed the application of MSCs for patients with COVID-19 in China and the related important issues with MSCs use during the outbreak. | 2020-06-01 |
| 32479411 | Technologies employed include mobile and web-based services such as Internet hospitals and Wechat, big data analyses (including digital contact tracing through QR codes or epidemic prediction), cloud computing, Internet of things, Artificial Intelligence (including the use of drones, robots, and intelligent diagnoses), 5G telemedicine, and clinical information systems to facilitate clinical management for COVID-19. | 2020-06-20 |
| 32479412 | Participants performed the specimen collection procedures during a telehealth video appointment while clinical observers watched and documented the suitability of the collection. […] Clinical observers assessed that of the samples collected, 147/153 (96.1%) of the saliva samples, 146/151 (96.7%) of the oropharyngeal samples, and 135/145 (93.1%) of the DBS samples were of sufficient quality for submission for laboratory testing; 100% of the OPS samples and 98% of the saliva samples had cycle threshold values for RNase P <30, indicating that the samples contained sufficient nucleic acid for RNA-PCR testing for SARS-CoV-2. […] Clinical observers rated the collection of specimens as suitable for testing, and visual and quantitative laboratory assessment indicated that the specimens were biologically sufficient. | 2020-06-26 |
| 32479413 | Social distancing requirements and stay-at-home orders have shifted patient care from face-to-face consultations in primary care offices to virtual care from clinicians’ homes or offices, moving to a new frontline, which we call the “frontweb.” Our telehealth workgroup employed the Clinical Transformation in Technology implementation framework to accelerate telehealth expansion and to develop a consensus document for clinician recommendations in providing remote virtual care during the pandemic. | 2020-06-26 |
| 32479680 | With the exponential increase of patients worldwide, the clinical spectrum of COVID-19 is being better defined and new symptoms are emerging. […] This narrative review summarizes the available data regarding clinical and histological features of COVID-19-associated skin manifestations. […] Literature reports showed a great heterogeneity in COVID-19-associated cutaneous manifestations, as well as in their latency periods and associated extracutaneous symptoms. […] Based on our experience and the literature data, we subdivided the reported cutaneous lesions into six main clinical patterns: i) urticarial rash, ii) confluent erythematous/maculo-papular/morbilliform rash, iii) papulovesicular exanthem, iv) chilblain-like acral pattern, v) livedo reticularis/racemosa-like pattern, vi) purpuric “vasculitic” pattern. | 2020-06-19 |
| 32479682 | To investigate the incidence of clinical, ultrasonographic and biochemical findings related to pre-eclampsia (PE) in pregnancies with COVID-19, and to assess their accuracy to differentiate between PE and the PE-like features associated with COVID-19. […] Incidence of signs and symptoms related to PE, such as hypertension, proteinuria, thrombocytopenia, elevated liver enzymes, abnormal UtAPI and increased sFlt-1/PlGF. […] Five (11.9%) women presented signs and symptoms of PE, all five being among the severe COVID-19 cases (62.5%). | 2020-06-22 |
| 32479758 | In this article the recently established COVID-19 Task Force of the German Society for Clinical Chemistry and Laboratory Medicine (DGKL) addresses these issues based on the currently available datasets in this rapidly moving field. | 2020-06-03 |
| 32479771 | Understanding risk of deterioration will assist in admission and discharge decisions, and help selection for clinical studies to indicate where risk of therapy-related complications is justified. […] Demographic details, clinical data, comorbidities, blood parameters and chest radiograph severity scores were collected from electronic health records. […] These predictors were incorporated into a risk score that will inform clinical care and stratify patients for clinical trials. | 2020-06-12 |
| 32479777 | In order to maintain activity with radiotherapy clinical assistance, we have implemented different measures in our centers from a patient and staff safety perspective. | 2020-06-26 |
| 32479787 | We aimed to describe clinical characteristics and outcomes of patients with cancer and COVID-19, and examined risk factors for mortality in this population. […] Clinical characteristics, laboratory data, and cancer histories were compared between survivors and non-survivors by use of χ2 test. | 2020-06-04 |
| 32479790 | We aimed to systematically characterise clinical features and determine risk factors of COVID-19 disease severity for patients with cancer and COVID-19. […] Demographic characteristics, laboratory examinations, illness severity, and clinical interventions were compared between patients with COVID-19 with or without cancer as well as between patients with cancer with non-severe or severe COVID-19. […] This study was registered in the Chinese Clinical Trial Register, ChiCTR2000030807. […] The risk factors identified here could be helpful for early clinical surveillance of disease progression in patients with cancer who present with COVID-19. | 2020-06-04 |
| 32479811 | Several uncertainties exist regarding how we will conduct our clinical, didactic, business, and social activities as the coronavirus disease 2019 (COVID-19) global pandemic abates and social distancing guidelines are relaxed. […] We anticipate changes in how we interact with our patients and other providers, how patient workflow is designed, the methods used to conduct our teaching sessions, and how we perform procedures in different clinical settings. […] The objective of the present report is to review some of the changes to consider in the clinical and academic oral and maxillofacial surgery workflow and, allow for a smoother transition, with less risk to our patients and healthcare personnel. […] New infection control policies should be strictly enforced and monitored in all clinical and nonclinical settings, with an overall goal to decrease the risk of exposure and transmission. […] Screening for COVID-19 symptoms, testing when indicated, and establishing the epidemiologic linkage will be crucial to containing and preventing new COVID-19 cases until a vaccine or an alternate solution is available. […] We have an opportunity now to make changes and embrace telemedicine and other collaborative virtual platforms for teaching and clinical care. […] It is crucial that we maintain COVID-19 awareness, proper surveillance in our microenvironments, good clinical judgment, and ethical values to continue to deliver high-quality, economical, and accessible patient care. | 2020-06-15 |
| 32479816 | This paper is an overview of this virus and the disease with a particular focus on SARS-CoV-2/COVID-19 clinical pathology, pathogenesis, and immunopathology, along with recent research developments. | 2020-06-09 |
| 32479829 | The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. | 2020-06-04 |
| 32479856 | The virus poses serious challenges to clinical management because there are still no approved anti- SARS-CoV-2 drugs available. | 2020-06-28 |
| 32479865 | The in vitro antiviral activity of darunavir against a clinical isolate from a patient infected with SARS-CoV-2 was assessed. | 2020-06-28 |
| 32479900 | However, not only has the effectiveness of HCQ remained questionable, but mainly based on preclinical and a few small clinical studies, HCQ is known to be potentially arrhythmogenic, especially as a result of QT prolongation. | 2020-06-22 |
| 32479911 | The patient had no postoperative deficits, and her symptoms completely improved. | 2020-06-27 |
| 32479979 | To describe clinical and pathologic findings of pernio-like lesions in confirmed or suspected COVID-19 cases. […] In patients with other COVID-19 symptoms, pernio-like lesions typically appeared after other symptoms. | 2020-06-03 |
| 32480008 | The reported prevalence of digestive symptoms ranges from 3% to 79%, depending on the setting,2-5 but data on GI endoscopic and histologic findings in COVID-19 patients are lacking. | 2020-06-28 |
| 32480326 | However, it has been also speculated about that using immunmodulators could be an advantage for the clinical prognosis. […] Despite using immunmodulator, the symptoms of the patient at hospitalization were mild and he did not show elevated D-dimer, and there was no lymphopenia. […] He was discharged to home-quarantine with no symptoms. | 2020-06-24 |
| 32480361 | Previous research has shown the feasibility of human activity recognition technologies for monitoring rehabilitation activities in home environments; however, few comprehensive studies ranging from development to clinical evaluation exist. […] From March 2018 to February 2019, we conducted a clinical study with two groups of stroke survivors. […] To measure clinical outcomes, we performed the Wolf Motor Function Test (WMFT), Fugl-Meyer Assessment of Upper Extremity, grip power test, Beck Depression Inventory, and range of motion (ROM) assessment of the shoulder joint at 0, 6, and 12 months, and at a follow-up assessment 6 weeks after retrieving the HBR system. […] Clinical Research Information Service KCT0004818; https://tinyurl.com/y92w978t. | 2020-06-02 |
| 32480420 | Management of COVID-19 may be particularly challenging in patients with AL amyloidosis who often present with cardiac dysfunction, nephrotic syndrome, neuropathy, low blood pressure and gastrointestinal symptoms. | 2020-06-19 |
| 32481322 | The following electronic databases will be used by 2 independent reviewers: Web of Science, Embase, Cochrane Library, PubMed, Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure, Chinese Scientific Journal Database, Wan fang Database, ClinicalTrials, WHO Trials, and Chinese Clinical Trial Registry. […] Clinical recovery time and effective rate will be assessed as the primary outcomes. […] Considering clinical heterogeneity, random effect model will be used for continuous outcomes. | 2020-06-08 |
| 32481340 | HFNC could prevent intubation in some patients, thereby avoiding the above complications; however, this needs confirmation in further clinical studies. | 2020-06-08 |
| 32481379 | Keywords of all related studies could be divided into 4 clusters: “Pathological research,” “Epidemiology research,” “Clinical research,” and “Mechanism research.” The outbreak of the epidemic could promote coronavirus research, meanwhile, coronavirus research contributes to overcoming the epidemic. | 2020-06-15 |
| 32481380 | There is no specific cure for this disease, and the clinical management mainly depends on supportive treatment. […] Our study aims to systematically present the clinical evidence of CHM in the treatment of COVID-19, which will be of guiding significance for further research and clinical practice. | 2020-06-15 |
| 32481460 | More and more clinical practice shows that traditional Chinese medicine has played an important role in the outbreak. […] Searches are limited to clinical studies published in Chinese and English. […] The systematic review and meta-analysis aims to review and pool current clinical outcomes of QPD combined with antiviral drugs for the treatment of COVID-19. | 2020-06-15 |
| 32481672 | This survey assessed the symptoms/signs, protective measures, awareness, and perception levels regarding COVID-19 among dentists in Lombardy, Italy. […] Five hundred two (14.43%) participants had suffered one or more symptoms referable to COVID-19. […] This survey demonstrated that dentists in the COVID-19 highest prevalence area, albeit reported to have more symptoms/signs than the rest of the sample, were the ones who adopted several precautionary measures less frequently and were the more confident of avoiding infection. | 2020-06-17 |
| 32481690 | As emerging infectious diseases, they were characterized by their novel pathogens and transmissibility without available clinical drugs or vaccines. | 2020-06-08 |
| 32482134 | The two biomarkers readily available in routine laboratories, blood lymphocytes and neutrophil counts, are expected to provide an accurate clinical tool to incline reasonable medication and care because lymphopenia marks immune exhaustion while neutrophilia demonstrates the immunological exuberation. | 2020-06-02 |
| 32482138 | To limit exposure and maintain a reserve of caregivers, residency education ceased most clinical activities and shifted to remote lecture consortiums hosted online across the country in lieu of ambulatory and operative experiences. […] Many practicing university otolaryngologists have transitioned their clinics to telehealth medicine to maintain access to clinical care during the pandemic. | 2020-06-02 |
| 32482155 | Pre- and postintervention self-evaluations were measured via standardized clinical competency questionnaires on a 5-point Likert scale ranging from “No knowledge, unable to perform” up to “Highly knowledgeable and confident, independent.” Forty-six participants in this study submitted pre- and postintervention self-assessments. | 2020-06-02 |
| 32482250 | Evidence suggests that COVID-19 infection has a lower maternal case fatality rate than SARS or Middle East respiratory syndrome (MERS), but anecdotal reports suggest that infected, asymptomatic women may develop respiratory symptoms postpartum. | 2020-06-10 |
| 32482336 | We aim to define national practice patterns to assess current clinical practice, anticipated delays and areas of concern that potentially could lead to deviations from the normal standard of care. […] However, the steep decline in clinical volume shows there is a large group of patients who are not being diagnosed or are deferring care. | 2020-06-05 |
| 32482483 | Many patients with COVID-19, the clinical illness caused by SARS-CoV-2 infection, exhibit mild symptoms and do not require hospitalization. […] Instead, these patients are often referred for 14-days of home isolation as symptoms resolve. | 2020-06-05 |
| 32482542 | The patient had no other typical symptoms of COVID-19 such as cough, dyspnea, nausea, vomiting, abdominal pain and diarrhea except for fever, but her epidemiological history was clear. | 2020-06-05 |
| 32482571 | There is currently not enough data in favour of danger or benefit from corticosteroids in COVID-19, so until this matter is resolved it is advisable to limit their indications to the most serious clinical pictures for which it is well established that this type of treatment has a positive impact on the progression of symptoms. | 2020-06-05 |
| 32482597 | During the 28-day follow-up, 69% of TCZ patients experienced a clinical improvement compared to 61% of standard treatment patients (p = 0.61). […] In TCZ group, at multivariate analysis, older age was a predictor of death, whereas higher baseline PaO2:FiO2 was a predictor of clinical improvement at day 28. […] At day 28, clinical improvement and mortality were not statistically different between tocilizumab and standard treatment patients in our cohort. | 2020-06-18 |
| 32482688 | During cohort isolation, nine patients showed symptoms but tested negative for SARS-CoV-2. | 2020-06-02 |
| 32482845 | Neurological symptoms have been reported as part of the clinical spectrum of the disease. […] Demographic characteristics, systemic and neurological clinical manifestations, and complementary tests were analyzed. […] Nonspecific symptoms such as myalgias (17.2%), headache (14.1%), and dizziness (6.1%) were present mostly in the early stages of infection. […] Anosmia (4.9%) and dysgeusia (6.2%) tended to occur early (60% as the first clinical manifestation) and were more frequent in less severe cases. | 2020-06-02 |
| 32482926 | Currently, there is no specific treatment for this virus and the treatment is mainly relied on controlling symptoms. | 2020-06-03 |
| 32483005 | Epidemiological, demographic, clinical, laboratory, treatment, and outcome data were collected and compared. […] No differences in disease severity and clinical outcomes were noted between the groups. | 2020-06-16 |
| 32483035 | Common symptoms include fever, cough, and shortness of breath. | 2020-06-19 |
| 32483311 | Their demographic data, clinical manifestations, laboratory indicators, and treatment methods were collected and analyzed. | 2020-06-05 |
| 32483409 | To fight with COVID-19, National Health and Commission of PRC has recommended some TCM in the guideline, such as HuoxiangZhengqi, LianhuaQingwen ShufengJiedu and XueBijing, and actually displayed a remarkable effect in clinical treatment strategic for COVID-19. | 2020-06-05 |
| 32483428 | While there is currently no specific treatment for COVID-19, several off label drugs approved for other indications are being investigated in clinical trials across the globe. | 2020-06-12 |
| 32483442 | Rationale: To retrospectively analyze serial chest CT and clinical features in patients with coronavirus disease 2019 (COVID-19) for the assessment of temporal changes and to investigate how the changes differ in survivors and nonsurvivors. Methods: The consecutive records of 93 patients with confirmed COVID-19 who were admitted to Wuhan Union Hospital from January 10, 2020, to February 22, 2020, were retrospectively reviewed. […] A series of chest CT findings and clinical data were collected and analyzed. […] Chest CT scores in different periods (0 - 5 days, 6 - 10 days, 11 - 15 days, 16 - 20 days, and > 20 days) since symptom onset were compared between survivors and nonsurvivors, and the temporal trend of the radiographic-clinical features was analyzed. Results: The final cohort consisted of 93 patients: 68 survivors and 25 nonsurvivors. | 2020-06-12 |
| 32483458 | We aimed to explore the predictive value of clinical, laboratory and CT imaging characteristics on admission for short-term outcomes of COVID-19 patients. Methods: This multicenter, retrospective, observation study enrolled 703 laboratory-confirmed COVID-19 patients admitted to 16 tertiary hospitals from 8 provinces in China between January 10, 2020 and March 13, 2020. […] Demographic, clinical, laboratory data, CT imaging findings on admission and clinical outcomes were collected and compared. […] The primary endpoint was in-hospital death, the secondary endpoints were composite clinical adverse outcomes including in-hospital death, admission to intensive care unit (ICU) and requiring invasive mechanical ventilation support (IMV). | 2020-06-12 |
| 32483488 | Clinical and laboratory biomarkers to predict the severity of coronavirus disease 2019 (COVID-19) are essential in this pandemic situation of which resource allocation must be urgently prepared especially in the context of respiratory support readiness. | 2020-06-05 |
| 32483490 | The selectivity determines susceptibility of clinical disease and extent of pathogenesis, including fatal lung and myocardial injury, and may be more cogent than the recently reported risk factors. | 2020-06-05 |
| 32483497 | While its effects on respiratory symptoms are well recognized, neurologic manifestations have been rarer. | 2020-06-05 |
| 32483507 | Symptoms were falsely attributed to the surgical procedure, leading to erroneous early management and a complicated postoperative course. […] In the era of the severe acute respiratory syndrome coronavirus 2 (SARs-CoV-2) pandemic, a high index of suspicion for coronavirus disease 2019 (COVID-19) symptoms and viral chest infection must be raised, primarily in vulnerable patients. | 2020-06-05 |
| 32483515 | Addressing areas of uncertainty will improve clinical outcomes and allow more effective policies to be implemented to control the disease. | 2020-06-05 |
| 32483523 | Many clinical trials on COVID-19 have been registered, and we aim to review the study characteristics and provide guidance for future trials to avoid duplicated effort. […] Thirty-one studies among 266 therapeutic studies (11.7%) used mortality as primary outcome, while the most designed secondary outcomes were symptoms and signs (47.0%). | 2020-06-05 |
| 32483524 | COVID-19 is known to cause serious respiratory symptoms and involvement of other body systems such as hematopoietic, neurological and the immune system. […] She suffered from headache and malaise with no respiratory symptoms, fever or chills. […] A narrow diagnostic approach where only febrile patients with pulmonary symptoms are evaluated for a COVID-19 diagnosis will result in many missed diagnoses; so it is important that physicians are familiar with atypical and rare presentations of COVID-19, such as isolated thrombocytopenia. | 2020-06-05 |
| 32483554 | One potential therapeutic approach currently being evaluated in numerous clinical trials is the agent remdesivir, which has endured a long and winding developmental path. […] Remdesivir is a nucleotide analogue prodrug that perturbs viral replication, originally evaluated in clinical trials to thwart the Ebola outbreak in 2014. […] Here, we provide an overview of remdesivir’s discovery, mechanism of action, and the current studies exploring its clinical effectiveness. | 2020-06-05 |
| 32483586 | We present a clinical validation of a RT-PCR assay for the SARS-CoV-2 nucleocapsid (N1) gene. […] Recovery of genomic RNA was improved by combining lysis buffer with clinical matrix prior to adding RNA. | 2020-06-26 |
| 32483687 | During the current context of COVID-19 pandemic, physicians should be aware of wide spectrum of neurological COVID-19 sign and symptoms for early diagnosis and isolation of patients. | 2020-06-05 |
| 32483811 | Currently, the knowledge regarding the clinical impact of COVID-19 on maternal, fetal, and placental aspects of pregnancy is minimal. | 2020-06-05 |
| 32483934 | Many respiratory viral infections such as influenza and measles result in severe acute respiratory symptoms and epidemics. | 2020-06-19 |
| 32484159 | Areas of innovation to improve our care during this time include increased use of wearable and remote devices to assess patient performance and vital signs, devices for facile cardiac assessment, and widespread use of clinical protocols for expedient discharge with virtual physical therapy and cardiac rehabilitation options. | 2020-06-12 |
| 32484225 | Meetings included relevant clinical education, updates, and leadership building. […] While we conducted real-time reverse transcriptase polymerase chain reaction SARS-CoV-2 laboratory tests for soldiers who were suspected to have COVID-19 (those presenting with compatible signs and symptoms after having been exposed to a confirmed COVID-19 patient), we were not able to screen healthy populations, nor did we have serum antibody serologic tests available during the study period. | 2020-06-26 |
| 32484298 | On admission, clinical, biochemical and anthropometric data, including BMI and NC were collected. | 2020-06-19 |
| 32484425 | To determine the relative correlations of Twitter and Google Search user trends concerning smell loss with daily coronavirus disease 2019 (COVID-19) incidence in the United States, compared to other severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) symptoms. […] Google Search and “tweet” frequency concerning COVID-19, smell, and nonsmell symptoms of COVID-19 generated between January 1 and April 8, 2020, were collected using Google Trends and Crimson Hexagon, respectively. […] Google searches and tweets concerning all nonsmell symptoms (0.744 and 0.761, respectively) and COVID-19 (0.899 and 0.848) are more strongly correlated with disease incidence than smell loss (0.564 and 0.539). | 2020-06-05 |
| 32484453 | To evaluate the clinical value of abnormal laboratory results of multiple organs in patients with coronavirus disease 2019 (COVID-2019) and to help clinicians perform correct treatment. | 2020-06-26 |
| 32484584 | It is unknown whether patients with PD are at greater risk of COVID-19, what their risk factors are, and whether their clinical manifestations differ from the general population. […] In an unselected large cohort of nonadvanced PD patients, COVID-19 risk and mortality did not differ from the general population, but symptoms appeared to be milder. | 2020-06-26 |
| 32484782 | More recently, real world data have been used for a wider range of research projects with the anticipation they could be used to support rapid, lower cost clinical trials. […] To describe the rapid design and development of the Oxford Royal College of General Practitioners Clinical Informatics Digital (ORCHID) Hub, and its first two platforms. […] The Surveillance Platform will provide extended primary care surveillance, while the Trials Platform will be a streamlined clinical trials platform integrated into routine primary care practice. […] We will apply the FAIR (Findable, Accessible, Interoperable and Reusable) metadata principles to a new, integrated digital health hub that will extract routinely collected general practice electronic health data for use in clinical trials and provide enhanced communicable disease surveillance. […] The secure data hub will host routinely collected general practice data linked to other key healthcare repositories for clinical trials and support enhanced surveillance in-situ, without always needing large volume data extracts. | 2020-06-02 |
| 32484930 | To recognize the period of exaggerated cytokine response in patients with Coronavirus disease 2019 (COVID-19) pneumonia, and to describe the clinical outcomes of using tocilizumab as a treatment option. […] Diagnostic tests, laboratory examinations, clinical findings and computed tomography of the thorax imaging results were evaluated. […] A dramatic laboratory and clinical improvement was observed in 83% (10/12) of patients after tocilizumab. […] Based on our experience with twelve adult COVID-19 pneumonia patients, we can say that tocilizumab, an IL-6 inhibitor, is more beneficial in preventing the damage caused by excessive cytokine response in the body if administered at the right time and provides clinical and radiological recovery. | 2020-06-19 |
| 32484958 | Patients with coronavirus disease-2019 may be discharged based on clinical resolution of symptoms, and evidence for viral RNA clearance from the upper respiratory tract. | 2020-06-19 |
| 32484966 | The scope for discussion is outside the neonatal period and entirely based on experimental and clinical experiences related to adults. | 2020-06-19 |
| 32485048 | This is concerning and likely reflects the fact that people are ignoring symptoms and delaying seeking medical advice due to fears related to Covid 19. | 2020-06-02 |
| 32485082 | A trend towards a beneficial effect of ACEi/ARB requires further evaluation in larger meta-analyses and randomised clinical trials. | 2020-06-03 |
| 32485101 | Currently, mounting evidence has shown the occurrence of neurological symptoms in patients with COVID-19. […] In any case, VEGF is deemed a promising therapeutic target in suppressing inflammation during SARS-CoV-2 infection with neurological symptoms. | 2020-06-26 |
| 32485147 | The panel was convened by video teleconference to discuss and then vote on statements related to 12 common clinical scenarios. […] Twelve statements related to baseline and annual lung cancer screening (n = 2), surveillance of a previously detected lung nodule (n = 5), evaluation of intermediate and high-risk lung nodules (n = 4), and management of clinical stage I non-small cell lung cancer (n = 1) were developed and modified. | 2020-06-05 |
| 32485197 | The delay between clinical suspicion and confirmatory testing adds to the complexity of the problem. […] Application of a clinical triage tool to guide isolation and cohorting decisions may reduce the risk of hospital acquired transmission of COVID-19 especially to individuals at the greatest of risk of severe disease. | 2020-06-05 |
| 32485289 | We systematically searched the database Pubmed including studies measuring psychiatric symptoms or morbidities associated with COVID-19 among infected patients and among none infected groups the latter divided in psychiatric patients, health care workers and non-health care workers. […] The two studies investigating COVID-19 patients found a high level of post-traumatic stress symptoms (PTSS) (96.2%) and significantly higher level of depressive symptoms (p = 0.016). […] Patients with preexisting psychiatric disorders reported worsening of psychiatric symptoms. […] Studies investigating health care workers found increased depression/depressive symptoms, anxiety, psychological distress and poor sleep quality. […] Studies of the general public revealed lower psychological well-being and higher scores of anxiety and depression compared to before COVID-19, while no difference when comparing these symptoms in the initial phase of the outbreak to four weeks later. […] A variety of factors were associated with higher risk of psychiatric symptoms and/or low psychological well-being including female gender, poor-self-related health and relatives with COVID-19. | 2020-06-25 |
| 32485299 | While elective activity has halted across the board nationally, the slow plateau of COVID-19 case rates prompts the question of timing of resumption of clinical activity. | 2020-06-26 |
| 32485314 | Empirical evidence of viral genomic material shedding weeks after apparent clinical and laboratorial resolution of COVID-19 may be an indirect proof for persistent viral infection. | 2020-06-16 |
| 32485335 | We retrospectively evaluated clinical and X-ray features in all patients referred to the emergency department for suspected SARS-CoV-2 infection between March 1st and March 13th. […] We stratified patients in groups according to the time interval between symptoms onset and X-ray imaging (≤ 5 and > 5 days) and according to age (≤ 50 and > 50 years old). […] Sensitivity was higher when symptoms had started more than 5 days before, at the expense of lesser specificity, while slightly higher in older patients in comparison to younger ones. | 2020-06-26 |
| 32485483 | In this work, we present the case of a man diagnosed with schizophrenia, who had been stable for more than 20 years and that presented with an atypical picture of psychotic and confusional symptoms related to COVID-19 infection. | 2020-06-23 |
| 32485487 | Italian healthcare professionals reported relevant work-related psychological pressure, emotional burnout and somatic symptoms. | 2020-06-23 |
| 32485610 | Often these are not prescribed by clinicians and patients/caregivers do not discuss the use with their clinical team. | 2020-06-22 |
| 32485618 | Ensuring accurate diagnosis is essential to limit the spread of SARS-CoV-2 and for the clinical management of COVID-19. | 2020-06-26 |
| 32485619 | To report the epidemiological and clinical futures of the 200 patients infected with COVID-19 in Yichang, Hubei Province, China. 200 patients confirmed with COVID-19 in a designated hospital in Yichang from Jan 30 to Feb 8, 2020 were investigated retrospectively. […] The epidemiological data and clinical characteristics were collected. […] The common symptoms included fever (171[85.5 %]), cough (116[58.0 %]), and fatigue (64[32 %]). | 2020-06-26 |
| 32485620 | Specimens from patients, with and without COVID-19 infection, were tested at the University of Chicago Clinical Microbiology and Immunology Laboratory. | 2020-06-26 |
| 32485859 | However, few studies have examined sleep problems, depression, and posttraumatic symptoms among the general adult population during the COVID-19 outbreak, and little is known about coping behaviors. | 2020-06-09 |
| 32485959 | It consisted of different investigations about sociodemographic aspects, profession-related characteristics, knowledge about COVID-19 infection transmission modalities, symptoms, and attitude in treating potentially infected patients. […] Italian dentists were informed correctly on the mode of transmission but partially missed COVID-19 symptoms. | 2020-06-09 |
| 32485970 | Through previous lessons learned from SARS-CoV-1 and MERS-CoV studies, scientific groups worldwide have rapidly expanded the knowledge pertaining to SARS-CoV-2 virology that includes in vitro and in vivo models for testing of antiviral therapies and randomized clinical trials. […] In the present narrative, we review SARS-CoV-2 virology, clinical features, pathophysiology, and animal models with a specific focus on the antiviral and adjunctive therapies currently being tested or that require testing in animal models and randomized clinical trials. | 2020-06-03 |
| 32486140 | Assertions in the literature suggest that respiratory disorders due to COVID-19 commonly present with pneumonia-like symptoms which are radiologically confirmed as opacities. | 2020-06-03 |
| 32486188 | Initially, infection presented with a broad spectrum of symptoms which typically included muscle aches, fever, dry cough, and shortness of breath. | 2020-06-03 |
| 32486196 | Several SARS-CoV-2 positive case studies have been reported where there are mild or no symptoms of this virus. | 2020-06-08 |
| 32486364 | This perspective review expounds recent nanoscience advancements for the detection and treatment of viral infections with focus on coronaviruses and encompasses nano-based formulations and delivery platforms, nanovaccines, and promising methods for clinical diagnosis, especially regarding SARS-CoV-2. | 2020-06-03 |
| 32486469 | Patients have had diverse clinical outcomes, but those developing COVID-19-related coagulopathy have shown a disproportionately worse outcome. […] This narrative review summarizes current evidence regarding the epidemiology, clinical features, known and presumed pathophysiology-based models, and treatment guidance regarding COVID-19 coagulopathy. | 2020-06-03 |
| 32486534 | The reverse transcription polymerase chain reaction (RT-PCR) was employed to detect 2019-nCoV nucleic acid in lung tissue, and the pathological characteristics were demonstrated in combination with clinical data analysis. Results: Of the 10 deaths associated with COVID-19, 7 were male and 3 were female. | 2020-06-05 |
| 32486556 | This article summarized the understanding of the etiology, pathogenesis, epidemiology, clinical characteristics, diagnosis, treatment, rehabilitation, and prevention and control measures of COVID-19 based on the available data and anti-epidemic experience in China. | 2020-06-04 |
| 32486557 | Objective: To investigate the clinical manifestations of the clinical characteristics of 141 patients with coronavirus disease 2019 (COVID-19) and the imaging evolution characteristics of High Resolution CT (HRCT) in the chest. Methods: From January 20, 2020 to February 8, 141 COVID-19 patients in Renmin Hospital of Wuhan University, 77 males and 64 females, with a median age of 49 (9,87) , were retrospectively analyzed. […] The clinical features, laboratory examination indexes and HRCT evolution findings of 141 COVID-19 patients were analyzed. Results: Laboratory examinations of 141 COVID-19 patients showed a decrease in white blood cell count and lymphocyte ratio. […] Among the 141 patients with COVID-19, fever (>37.5 ℃) was the most common clinical manifestation in 139 cases (98.58%) , and occasionally non-respiratory symptoms such as diarrhea in 4 cases (2.84%) . 141 patients with COVID-19 had abnormal HRCT. […] The differences in CT typing at different time were statistically significant (P<0.05) . Conclusion: The clinical features of COVID-19 and HRCT images are diverse, extensive GGO and infiltrates in both lungs are typical. […] In some epidemiological backgrounds, CT imaging manifestations and evolutionary characteristics are of great significance for early warning of lung injury, assessment of disease severity, and assistance in clinical typing and post-treatment follow-up. 目的： 探讨新型冠状病毒肺炎（COVID-19）临床表现及高分辨率CT（HRCT）影像分型和影像演变特征的临床意义。 | 2020-06-04 |
| 32487005 | The COVID-19 virus directly targets the lungs, leading to pneumonia-like symptoms and shortness of breath with life-threatening consequences. | 2020-06-03 |
| 32487093 | The outbreak of the novel coronavirus disease 2019 (COVID-19) and consequent social distancing practices have disrupted essential clinical research functions worldwide. […] As the global crisis has already led to over 15,000 deaths out of 175,000 confirmed cases in New York City and Nassau County, NY alone, it is increasingly urgent to collect patient biospecimens linked to active clinical follow up. | 2020-06-11 |
| 32487159 | Herein, we summarize the virology, epidemiology, clinical manifestations, diagnosis, treatment and prevention of SARS-CoV-2, and hope that countries can control the outbreak as soon as possible to minimize the loss. | 2020-06-17 |
| 32487271 | This study aimed to investigate the clinical characteristics and to analyse the epidemiological features of coronavirus disease 2019 (COVID-19) patients during convalescence. […] Clinical data were collected and analysed statistically. […] In all, 52.9% of adult patients (36/68) had no obvious clinical symptoms, and the remaining ones had mild and non-specific clinical symptoms (e.g. cough, sputum, sore throat, disorders of the gastrointestinal tract etc.). | 2020-06-22 |
| 32487272 | Despite political narratives, the legal texts show that the UK seeks de facto continuity in selected key areas for pharmaceuticals, medical devices, and equipment [including personal protective equipment (PPE)], especially clinical trials, pharmacovigilance, and batch-testing. | 2020-06-04 |
| 32487434 | Multidisciplinary intestinal failure teams may have to adapt their clinical approaches to home care, outpatient care as well as hospital admission and discharge in order to keep this vulnerable group of patients as safe and well as possible during the unprecedented challenges that countries are facing during the pandemic. […] The Home Artificial Nutrition & Chronic Intestinal Failure Special Interest Group of the European Society for Clinical Nutrition and Metabolism (ESPEN) has developed a position paper to outline areas for intestinal failure teams to consider when managing patients with chronic intestinal failure during the SARS-CoV-2 pandemic. | 2020-06-05 |
| 32487491 | A series of multiple linear regressions examined unique associations among adolescents’ motivations to engage in social distancing, perceived amount of social distancing, anxiety symptoms, depressive symptoms, burdensomeness, and belongingness. […] Specific motivations for social distancing were differentially associated with adolescents’ anxiety symptoms, depressive symptoms, burdensomeness, and belongingness. | 2020-06-05 |
| 32487513 | During the ongoing COVID-19 pandemic due to the SARS-CoV-2 virus of which evidence-based medical paradigms cannot be easily applied; difficult clinical decisions shall be required particularly in the ‘difficult-to-treat’ cases of high risk group with associated comorbidities. | 2020-06-05 |
| 32487681 | However, as with all novel assays, significant validation is required to understand the clinical relevance of results.We present the first study to assess clinician interpretation of SARS-CoV-2 serology scenarios. | 2020-06-12 |
| 32487789 | For this observational, retrospective and cross-sectional study, the epidemiological data records were collected from the Hospitals and the Ministry of Health of Bolivia, obtaining the clinical and epidemiological data of the COVID-19 cases that were laboratory-diagnosed during March 2-29, 2020. | 2020-06-11 |
| 32487793 | He was discharged after one month and his clinical conditions showed rapid improvement, with nearly complete normalization of the radiological pattern in three months. […] We report this case as the interest in influenza-associated IPA is high, both due to the clinical severity of this condition, which is treatable if identified early, and the emerging importance of respiratory infections caused by viruses belonging to the SARS family, such as SARS-CoV-2. | 2020-06-11 |
| 32487868 | The aim of this position paper is to provide clinical recommendation regarding the execution of imaging investigations for the cardiac diagnostic work-up of paediatric patients with suspected or confirmed infection. | 2020-06-17 |
| 32487876 | The goal of this review is to discuss the deluge of scientific data and how it might influence clinical reasoning and practice. | 2020-06-16 |
| 32487990 | Here, we estimate impacts of ramping up and accelerating baloxavir treatment on population-level incidence using a new model that links viral load dynamics from clinical trial data to between-host transmission. | 2020-06-04 |
| 32488318 | Several reports in literature show cutaneous lesions similar to chilblain, urticarial eruptions, diffuse or disseminated erythema, livedo racemosa, blue toe syndrome, retiform purpura, vesicle trunk, purpuric exanthema or exanthema with clinical aspects of symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) and others. […] This review describes the complexity of Covid-19, pathophysiological and clinical aspects, dermatological finding and other dermatological conditions associated with SARS-CoV-2 infection or COVID-19. | 2020-06-05 |
| 32488422 | This requires clear communication and leadership structures, communication training, psychosocial support, but most of all optimal framework conditions for the clinical work. | 2020-06-05 |
| 32488493 | There is evidence that a proportion of those infected with SARS-CoV-2 have detectable viral loads prior to exhibiting symptoms, or without ever developing symptoms. […] Viral transmission from patients exhibiting no symptoms in the operating room is plausible and efforts to reduce risk to healthcare providers include reducing aerosolization and wearing appropriate personal protective equipment, the feasibility of which will vary based on geographic risk and equipment availability. | 2020-06-05 |
| 32488505 | This is a case series performed at 4 academic tertiary care centers in Paris of all the children admitted to the pediatric intensive care unit (PICU) with shock, fever and suspected SARS-CoV-2 infection between April 15th and April 27th, 2020. 20 critically ill children admitted for shock had an acute myocarditis (left ventricular ejection fraction, 35% (25-55); troponin, 269 ng/mL (31-4607)), and arterial hypotension with mainly vasoplegic clinical presentation. […] The first symptoms before PICU admission were intense abdominal pain and fever for 6 days (1-10). | 2020-06-05 |
| 32488888 | This study aimed to investigate the clinical significance of liver blood tests in COVID-19 patients. […] The analysis included clinical data of 23 patients with suspected COVID-19 and 66 patients with confirmed COVID-19 from January 25 to February 20, 2020. | 2020-06-19 |
| 32488910 | Still, cutaneous manifestations are uncommonly reported and the majority has no clinical or histological pictures. | 2020-06-19 |
| 32488946 | Skins symptoms during COVID-19 have been recently described but their relation to SARS-CoV-2 is unclear while results for real-time reverse transcriptase polymerase chain reaction (rRT-PCR) testing were variable. […] Recalcati et al. reported 14 cases of patients with skin symptoms consistent with previous described COVID-19 lesions but all the patients were tested negative. | 2020-06-19 |
| 32488957 | In response to the recent COVID-19 pandemic, many laboratories are involved in research supporting SARS-CoV-2 vaccine development and clinical trials. | 2020-06-19 |
| 32488958 | This study aimed to investigate clinical characteristics, laboratory indexes, treatment regimens, and short-term outcomes of severe and critical coronavirus disease 2019 (COVID-19) patients. […] Demographic features, medical histories, clinical symptoms, lung computerized tomography (CT) findings, and laboratory indexes on admission were collected. […] Post-admission complications, treatment regimens, and clinical outcomes were also documented. […] Fever (127 [78.88%]) and dry cough (111 [68.94%]) were the most common symptoms. | 2020-06-19 |
| 32489022 | In the previous research, our laboratory established a mouse model combining disease with syndrome of human coronavi-rus pneumonia with pestilence attacking the lung syndrome, based on the national traditional Chinese medicine clinical classification of Novel Coronavirus Infected Pneumonia Diagnosis and Treatment Plan. […] In this study, a mouse model combining disease with syndrome of human coronavirus pneumonia with pestilence attacking the lung syndrome was used to evaluate the effectiveness of Reyanning Mixture to provide animal experimental support for clinical application. […] It manifested obvious effects in improving lung lesions, enhancing the gastrointestinal function of mice, improving the autoimmune function of mice, and reducing the expression of inflammatory factors in vivo, which could provide evidences for clinical research. | 2020-06-05 |
| 32489023 | The aim of this paper was to investigate the therapeutic effect of Compound Qinlan Oral Liquid recommended by Provincial Novel Coronary Virus Pneumonia Treatment Scheme on the treatment of BALB/c mice with combining disease with syndrome of human coronavirus pneumonia with pestilence attacking lung syndrome and to explore its clinical application in the treatment of novel coronavirus pneumonia, and to provide laboratory data support for clinical Chinese medicine. | 2020-06-05 |
| 32489024 | Clinical observation shows that patients in the recovery period are mostly at the status that the remaining virus toxicity is not exhausted while the vital Qi have not recovered. […] The results of this study are expected to provide references for clinical medication in preventing and treating pulmonary fibrosis caused by COVID-19. | 2020-06-05 |
| 32489025 | In this study, the molecular interaction networks of different stages of COVID-19(the early, severe, critical and recovery stage) were constructed using the links among symptoms-related genes collected from TCMIP V2.0(http://www.tcmip.cn/), an integrated pharmacology network-computing platform for TCM. […] Accordingly, the therapeutic targets and pathways hit by the recommended prescriptions against COVID-19 were also aimed to regulate the balance of immune-inflammation system, nutrient absorption and metabolism, abnormal energy metabolism, the cardio-pulmonary function, nerve system function, etc., which may be related to the therapeutic effects of these prescriptions in terms of several clinical symptoms, such as expiratory dyspnea, chest tightness and shortness of breath, abdominal distension and constipation, sweating and limb cold, dizziness, and irritability, etc. | 2020-06-05 |
| 32489026 | This study revealed potential active components of Qingwen Baidu Yin in defending against cytokine storm and its possible mechanism of action, and provided theoretical basis and technical support for further clinical application of this prescription. | 2020-06-05 |
| 32489027 | The common clinical symptoms of viral pneumonias include fever, rhinitis, runny nose, nonproductive cough, fatigue, myalgias and headaches after the immune system being tricked by driving cytokines and overactivated immune response induced by cytokine storms. […] Patients with severe symptoms could get persistent high fever, dysfunctional breathing, consciousness disorders and even respiratory failure, post-inflammatory pulmonary fibrosis, multi-organ damages, shock and so on. […] Most clinical treatments are used to inhibit virus replication, relieve symptoms, inhibit excessive inflammatory response, regulate immune balance and protect organs. […] Both applied and basic research demonstrate that Chinese patent medicine has certain anti-viral effects, effectively inhibiting viral pneumonia transiting from mild to severe, rapid relieving of patient symptoms because of their multi-component and multi-target integrated roles. […] Our paper summarizes the advantages of Chinese patient medicine in the treatment of viral pneumonia, based on which improvements of clinical therapy are expected to be made soon. | 2020-06-05 |
| 32489028 | Qingfei Paidu Decoction is a traditional Chinese medicine compound recommended by National Health Commission of the People’s Republic of China and National Administration of Traditional Chinese Medicine for clinical therapies of coronavirus disease 2019(COVID-19). […] We also found that the dose of Asari Radix et Rhizoma in ancient and modern clinical applications was not constrained by ancient experience. […] Physicians usually increase the dosage of Asari Radix et Rhizoma in clinical therapy according to the actual conditions, and there were no adverse reactions. | 2020-06-05 |
| 32489029 | These therapeutic methods and prescriptions intervened with both virus and host at the same time in the treatment of COVID-19, which has important implications for the effective clinical treatment of COVID-19. | 2020-06-05 |
| 32489030 | The analysis and utilization of clinical scientific research data is an effective means to promote the progress of diagnosis and treatment, and a key step in the development of medical sciences. […] During the epidemic of coronavirus disease 2019(COVID-19), how to transform the limited diagnostic data into clinical research resources has attracted much attention. […] Based on the low efficiency of data collection and extraction, the inconsistency of data analysis, the irregularity of data report and the high timeliness of data update during the epidemic, this paper briefly analyzed the background and reasons of data application under the current situation, and then discusses the problems and feasible solutions of clinical data applications under the epidemic situation and, more importantly, for future medical clinical research methods. […] We put forward several methodological suggestions: ① gradually improve the medical big data model and establish the national medical health data center; ② improve the scientific research literacy of medical staff and popularize the basic skills and knowledge of GCP; ③ promote a scientific, networked and shared data collection and management mode; ④ use the mixed research method and collective analysis to improve the efficiency of clinical data analysis; ⑤ pay attention to narration of the medical feelings and emphasize the humanistic data of clinical medicine. […] It is expected to promote the standardized and reasonable use of clinical scientific research data, the rigorous integration of expert opinions, and ultimately the development of big data for national health care. | 2020-06-05 |
| 32489031 | Given that the relevant systems need to be improved, and that the integration of standardized reports and clinical research is not mature,as well as other problems, we put forward several methodological suggestions: ① Establish national medical and health data center and improve relevant laws and regulations. | 2020-06-05 |
| 32489162 | In conclusion, exposed hospital staff continued work, accompanied by close clinical and virologic monitoring. | 2020-06-19 |
| 32489188 | The stress caused by pandemic is a new condition in comparison with what is known in clinical practice and with what is included in the classification of mental disorder. […] The ongoing stress condition and the mixture of different types of unconventional stress, which not only hits the present but also disrupts the future, create an entirely new form of clinical condition given by pandemic. | 2020-06-11 |
| 32489189 | The stress caused by pandemic is a new condition in comparison with what is known in clinical practice and with what is included in the classification of mental disorder. […] The ongoing stress condition and the mixture of different types of unconventional stress, which not only hits the present but also disrupts the future, create an entirely new form of clinical condition given by pandemic. | 2020-06-11 |
| 32489190 | This review aims at synthesizing mounting evidence concerning the immediate psychological responses during the initial stage of the CoViD-19 pandemic among the general population, the health-care workers, and clinical populations. | 2020-06-11 |
| 32489191 | A third of people experienced symptoms of mild/moderate and severe peritraumatic distress. | 2020-06-11 |
| 32489248 | The management of cancer patients has been affected, with adoption of telemedicine reported by 82% of respondents, and cessation of clinical trial accrual reported by 54%. | 2020-06-17 |
| 32489437 | By March 12, 2020, there are more than 382 studies registered in the clinical trials databases addressing COVID-19 including more than 80 randomized controlled trials. | 2020-06-05 |
| 32489502 | Most cases result in minor symptoms such as cough, fever, sore throat, myalgia, fatigue, nausea, diarrhea, loss of smell, and abdominal pain. | 2020-06-05 |
| 32489695 | We analyze the current pattern of SARS-CoV-2 transmission, testing, and mortality in India with an emphasis on the importance of mortality as a marker of the clinical relevance of COVID-19 disease. | 2020-06-05 |
| 32489708 | In this study we retrospectively reviewed the clinical and laboratory characteristics of 18 COVID-19 patients from January 30, 2020 to February 21, 2020. | 2020-06-05 |
| 32489711 | In order to explore the effects of comorbid chronic diseases on clinical outcomes of COVID-19, a search was conducted in PubMed, Ovid MEDLINE, EMBASE, CDC, and NIH databases to April 25, 2020. | 2020-06-05 |
| 32489724 | We report a case of a 54-year-old patient who presented with unique clinical characteristics and imaging with brain basal ganglia involvement likely due to SARS-CoV-2 infection. | 2020-06-05 |
| 32489743 | We observe that SARS-CoV-2 may have various neurological manifestations and in many cases, neurological features may precede typical respiratory symptoms. | 2020-06-05 |
| 32489929 | Furthermore, CT imaging appearances are correlated with patients presenting with different clinical scenarios, such as early versus advanced stages, asymptomatic versus symptomatic patients, and severe versus nonsevere situations. | 2020-06-05 |
| 32490022 | Clinical manifestations occur shortly after exposure, or a few days later. | 2020-06-05 |
| 32490304 | Based on related laws and regulations, such as the Law of the People’s Republic of China on Prevention and Control of Infectious Diseases, clinical manifestations and epidemiological characteristics of COVID-19 and guidelines on the prevention and control of this epidemic, combined with the practical work of forensic pathology examinations, we developed the Guide to Forensic Pathology Practice for Death Cases Related to Coronavirus Disease 2019 (COVID-19) (Trial Draft). | 2020-06-05 |
| 32490506 | A patient with diabetes mellitus and hypertension for five years was admitted to the emergency unit with symptoms of fever, cough and dyspnoea. […] These symptoms were consistent with viral pneumonia and a COVID PCR test was performed, which tested positive three days later. | 2020-06-03 |
| 32490559 | One hundred twenty-two individuals with IDD were placed in quarantine for exhibiting symptoms and signs of acute infection such as fever or cough. | 2020-06-22 |
| 32490720 | Telemedicine offers a support to traditional medicine, delivering clinical services when distance is a critical factor. | 2020-06-26 |
| 32490723 | A total of 101 clinical swine samples with signs of diarrhea were analyzed using this method, and the result showed good consistency with conventional reverse transcription PCR (RT-PCR). | 2020-06-15 |
| 32490829 | We aimed to explore the imaging findings of computed tomography (CT) in diagnosing coronavirus disease 2019 (COVID-19) and its clinical value for further evaluation of suspected cases. […] Among them, 140 cases (including 82 males and 58 females) were included as suspected COVID-19 cases based on clinical and epidemiological history; the CT image features of 70 cases with suggestive findings on CT, confirmed by positive nucleic acid test were analyzed and evaluated. | 2020-06-03 |
| 32490843 | A dashboard was created for the medical staff to view the vital signs and symptoms of all patients. | 2020-06-23 |
| 32490846 | The aims of this study were to detect and characterize user-generated conversations that could be associated with COVID-19-related symptoms, experiences with access to testing, and mentions of disease recovery using an unsupervised machine learning approach. […] Tweets were collected from the Twitter public streaming application programming interface from March 3-20, 2020, filtered for general COVID-19-related keywords and then further filtered for terms that could be related to COVID-19 symptoms as self-reported by users. […] Tweets were analyzed using an unsupervised machine learning approach called the biterm topic model (BTM), where groups of tweets containing the same word-related themes were separated into topic clusters that included conversations about symptoms, testing, and recovery. […] A total of 4,492,954 tweets were collected that contained terms that could be related to COVID-19 symptoms. […] After using BTM to identify relevant topic clusters and removing duplicate tweets, we identified a total of 3465 (<1%) tweets that included user-generated conversations about experiences that users associated with possible COVID-19 symptoms and other disease experiences. […] These tweets were grouped into five main categories including first- and secondhand reports of symptoms, symptom reporting concurrent with lack of testing, discussion of recovery, confirmation of negative COVID-19 diagnosis after receiving testing, and users recalling symptoms and questioning whether they might have been previously infected with COVID-19. […] The co-occurrence of tweets for these themes was statistically significant for users reporting symptoms with a lack of testing and with a discussion of recovery. […] This study used unsupervised machine learning for the purposes of characterizing self-reporting of symptoms, experiences with testing, and mentions of recovery related to COVID-19. […] Many users reported symptoms they thought were related to COVID-19, but they were not able to get tested to confirm their concerns. | 2020-06-15 |
| 32490853 | Here, an integrated point-of-care COVID-19 Severity Score and clinical decision support system is presented using biomarker measurements of C-reactive protein (CRP), N-terminus pro B type natriuretic peptide (NT-proBNP), myoglobin (MYO), D-dimer, procalcitonin (PCT), creatine kinase-myocardial band (CK-MB), and cardiac troponin I (cTnI). […] These promising initial models pave the way for a point-of-care COVID-19 Severity Score system to impact patient care after further validation with externally collected clinical data. […] Clinical decision support tools for COVID-19 have strong potential to empower healthcare providers to save lives by prioritizing critical care in patients at high risk for adverse outcomes. | 2020-06-25 |
| 32490854 | Results show potential for a highly specific liquid biopsy method that could be used in point-of-care clinical diagnostics to increase early cancer detection or any other diseases including SARS-CoV-2 in which RNAs can be used as biomarkers. | 2020-06-24 |
| 32490887 | Dentists are strongly recommended to take maximum precautions in the clinical setting. | 2020-06-08 |
| 32490891 | Thus, in order to understand how the departments of Angiology and Vascular Surgery are acting in the context of the COVID-19 pandemic, this work aims to gather studies that reveal from protocols applied in vascular services in the current situation, until to the role of vascular surgeons and angiologists in the clinical and surgical management of patients infected or not, as a way of helping and clarifying this specialty during the context of a pandemic due to the new coranavirus. | 2020-06-09 |
| 32490966 | A total of 43 articles were selected, including data ranging from common, non-specific symptoms, such as hyposmia and myalgia, to more complex and life-threatening conditions, such as cerebrovascular diseases, encephalopathies, and Guillain-Barré syndrome. | 2020-06-16 |
| 32491075 | Respiratory symptoms, especially the development of severe acute respiratory distress syndrome, dominate the discussion and initial concerns of the population and health professionals. | 2020-06-09 |
| 32491103 | Clinical and laboratory data and findings of non-enhanced CT indicate possibility of acute pulmonary embolism, and support the decision to proceed with computed tomography pulmonary angiography that can objectively identify filling defects in pulmonary arterial branches. | 2020-06-19 |
| 32491104 | Here, we report the clinical characteristics and therapeutic procedure for a case of severe NCP. […] After treatment, the patient’s symptoms improved, and the status was confirmed as NCP negative. | 2020-06-06 |
| 32491199 | COVID-19 convalescent plasma (CCP)-specific donor screening and selection were performed based the following criteria: 1) aged 18-55 years; 2) eligible for blood donation; 3) diagnosed with COVID-19; 4) had two consecutive negative COVID-19 nasopharyngeal swab tests based on PCR (at least 24 h apart) prior to hospital discharge; 5) had been discharged from the hospital for more than 2 weeks; and 6) had no COVID-19 symptoms prior to convalescent plasma donation. […] In addition, preference was given to CCP donors who had a fever lasting more than 3 days or a body temperature exceeding 38.5 Celsius, and 4 weeks after the onset of symptoms. | 2020-06-19 |
| 32491214 | In 1991 and 2009 the Italian sentinel surveillance system was established, consisting in 25 public centers (12 clinical, 13 laboratories) on the national field for diagnosis, treatment and data transmission to the INIH4 . | 2020-06-19 |
| 32491257 | Chest computed tomography (CT) has shown tremendous clinical potential for screening, diagnosis, and surveillance of COVID-19. | 2020-06-19 |
| 32491298 | This study aimed to assess self‑reported frequency of gastrointestinal symptoms and olfactory or taste disorders in nonhospitalized patients with COVID‑19 in Poland. […] The questionnaire included 8 questions related to the health status, symptoms of COVID‑19, comorbidities, and smoking status. […] Self‑reported frequency of gastrointestinal symptoms and olfactory or taste disorders during COVID‑19 was significantly higher (P <0.001) in women than men. […] This study demonstrated that olfactory and taste disorders are frequent symptoms in patients with mild‑to‑moderate COVID‑19. […] Moreover, our study indicated sex differences in the frequency of gastrointestinal symptoms and olfactory or taste disorders among nonhospitalized patients with COVID‑19. | 2020-06-26 |
| 32491306 | The virus is now widespread and causing the current pandemic of COVID-19, a highly pathogenic viral pneumonia, commonly presented with fever and cough, which frequently lead to lower respiratory tract disease with poor clinical outcomes associated with older age and underlying health conditions. | 2020-06-03 |
| 32491829 | Like severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a respiratory virus infecting the lungs with fever, dry cough, and acute pneumonia being the major symptoms. […] Based on evolving clinical evidence, it is now unfitting to label SARS-CoV-2 as just a respiratory virus, as lately there are various reports that substantiate its pathogenicity in other organs of the body, including brain. | 2020-06-19 |
| 32491919 | Asymptomatic infection may be associated with subclinical lung abnormalities, as detected by computed tomography. […] Because of the high risk for silent spread by asymptomatic persons, it is imperative that testing programs include those without symptoms. | 2020-06-19 |
| 32491949 | Understanding the age-based differences in pathophysiological pathways and processes relevant to the onset and progression of disease both in the clinical course and in experimental disease models may hold the key to the identification of therapeutic targets. […] The differences in the clinical course are highlighted by the lack of progression of the SARS-CoV-2 infection beyond mild symptoms in a majority of children, whereas in adults the disease progresses to acute lung injury and an acute respiratory distress syndrome (ARDS)-like phenotype with high mortality. | 2020-06-26 |
| 32491976 | School nurses may deal with students presenting with symptoms associated with infections popularized in the news. […] We present three students presenting with febrile illnesses associated with neurologic symptoms, a rash, and fatigue, focusing on the initial assessment and management of these students and their associated “hot topic” infection. | 2020-06-22 |
| 32491984 | We report the clinical features of 3 patients in France who had parotitis (inflammation of the parotid salivary glands) as a clinical manifestation of confirmed coronavirus disease. […] Results from magnetic resonance imaging support the occurrence of intraparotid lymphadenitis, leading to a parotitis-like clinical picture. | 2020-06-03 |
| 32492045 | However, wearing N95 respirators can prevent 73 more (95% CI 46-91) clinical respiratory infections per 1000 HCWs compared to surgical masks (2 RCTs; 2594 patients; low quality of evidence). […] However, low quality evidence suggests that N95 respirators protect HCWs from clinical respiratory infections. | 2020-06-09 |
| 32492084 | Convalescent plasma is a potential therapeutic option for patients with coronavirus disease 2019 (COVID-19), but further data from randomized clinical trials are needed. […] Open-label, multicenter, randomized clinical trial performed in 7 medical centers in Wuhan, China, from February 14, 2020, to April 1, 2020, with final follow-up April 28, 2020. […] Primary outcome was time to clinical improvement within 28 days, defined as patient discharged alive or reduction of 2 points on a 6-point disease severity scale (ranging from 1 [discharge] to 6 [death]). […] Clinical improvement occurred within 28 days in 51.9% (27/52) of the convalescent plasma group vs 43.1% (22/51) in the control group (difference, 8.8% [95% CI, -10.4% to 28.0%]; hazard ratio [HR], 1.40 [95% CI, 0.79-2.49]; P = .26). […] Among patients with severe or life-threatening COVID-19, convalescent plasma therapy added to standard treatment, compared with standard treatment alone, did not result in a statistically significant improvement in time to clinical improvement within 28 days. […] Chinese Clinical Trial Registry: ChiCTR2000029757. | 2020-06-13 |
| 32492092 | Descriptions of the coronavirus disease 2019 (COVID-19) experience in pediatrics will help inform clinical practices and infection prevention and control for pediatric facilities. […] To describe the epidemiology, clinical, and laboratory features of patients with COVID-19 hospitalized at a children’s hospital and to compare these parameters between patients hospitalized with and without severe disease. […] This retrospective review of electronic medical records from a tertiary care academically affiliated children’s hospital in New York City, New York, included hospitalized children and adolescents (≤21 years) who were tested based on suspicion for COVID-19 between March 1 to April 15, 2020, and had positive results for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] The median days from onset of symptoms to admission was 2 days (interquartile range, 1-5 days). […] Most patients (40 [80%]) had fever or respiratory symptoms (32 [64%]), but 3 patients (6%) with only gastrointestinal tract presentations were identified. | 2020-06-28 |
| 32492123 | Children are more likely to be asymptomatic or have milder symptoms and less likely to present for healthcare and be tested for SARS-CoV-2; thus, our current estimates are likely under-representative of the true burden of SARS-CoV-2 in children. […] We detail considerations for vaccine clinical trials, potential barriers to the implementation of widespread vaccination and argue why children would be an ideal target population for vaccination. | 2020-06-26 |
| 32492165 | The epidemiologic and clinical characteristics of pediatric patients with coronavirus disease 2019 (COVID-19) have been reported, but information on immune features associated with disease severity is scarce. […] Clinical and immunologic characteristics were collected and analyzed. […] Of the 157 pediatric patients with COVID-19, 60 (38.2%) had mild clinical type with pneumonia, 88 (56.1%) had moderate cases, 6 (3.8%) had severe cases, and 3 (1.9%) were critically ill. […] Gaining a deeper understanding of the role of neutrophils, CD4+ T cells, and B cells in the pathogenesis of SARS-CoV-2 infection could be important for the clinical management of COVID-19. | 2020-06-11 |
| 32492183 | This theoretical interpretation awaits experimental and clinical confirmation. | 2020-06-19 |
| 32492188 | His clinical course of the COVID-19 pneumonia improved smoothly in 9 days; however, his immune status from HIV infection was not well-controlled due to a lack of antiretroviral therapy (ART). | 2020-06-19 |
| 32492193 | A multipronged attack could potentially explain the severity and extensive variety of signs and symptoms observed in patients with COVID-19. […] Initial multiple organ involvement may present with vague signs and symptoms to alert healthcare professionals early in the course of COVID-19. | 2020-06-19 |
| 32492196 | Therefore, this universal SARS-CoV-2 enrichment probe system can capture and enrich SARS-CoV-2 viral sequences selectively and effectively in different samples, especially clinical swab samples with a relatively low concentration of viral particles. | 2020-06-19 |
| 32492197 | The virus is highly contagious, and clinical consequences were very divers. […] In this review article, we have collected the latest data about characteristics, pathogenesis, clinical manifestations, and diagnostic methods of SARS-CoV-2. | 2020-06-19 |
| 32492206 | In the forwarding days, randomized genome data will certainly voluminate in Bangladesh, however because of globalization and immigrant movements, we urgently need a mass regional sequencing approach targeting the partial or complete genome that can link the epidemiological data and may help in further clinical interventions. | 2020-06-19 |
| 32492209 | We sought to determine the clinical characteristics relevant to the clinical course of COVID-19 by comparing the family cluster to unrelated patients with SARS-CoV-2 infection so that the presence of potential determinants of disease severity, other than traditional risk factors previously reported, could be investigated. 29 patient files were investigated in Group 1 and Group 2 was created with 52 consecutive COVID-19 patients with age and gender compatibility. […] The clinical, laboratory and imaging features of all patients were retrospectively screened. […] In the present study, COVID-19 cases in the large family cluster were shown to have more severe disease and worse clinical course compared to consecutive COVID-19 patients presenting to the same time. | 2020-06-19 |
| 32492211 | Additionally, demographic, clinical, treatment, laboratory and outcome data were also collected from electronic medical records. | 2020-06-19 |
| 32492251 | Despite the epidemiological importance, clinical patterns of children with COVID-19 remain unclear. […] The aim of this study was to describe the clinical, laboratorial, and radiological characteristics of children with COVID-19. […] Inclusion criteria were (a) studied patients younger than 18 years old; (b) presented original data from cases of COVID-19 confirmed by reverse-transcription polymerase chain reaction; and (c) contained descriptions of clinical manifestations, laboratory tests, or radiological examinations. […] The most prevalent symptom was fever (47.5%), followed by cough (41.5%), nasal symptoms (11.2%), diarrhea (8.1%), and nausea/vomiting (7.1%). […] Clinical manifestations of children with COVID-19 differ widely from adult cases. […] Fever and respiratory symptoms should not be considered a hallmark of COVID-19 in children. | 2020-06-19 |
| 32492290 | The present information regarding the clinical features of COVID-19 infection in the dialysis population was collected, and the useful measures of COVID-19 infection prevention and infection control in the dialysis facilities were summarized. | 2020-06-25 |
| 32492354 | We describe lessons learned to improve the efficiency of future clinical trials, particularly in the setting of pandemics. | 2020-06-03 |
| 32492485 | This study aims to compare the epidemiology and the clinical characteristics of SARS-CoV-2 infection in asymptomatic and symptomatic individuals. […] Epidemiological and clinical characteristics were compared. […] 27.4% of well-documented asymptomatic cases developed delayed symptoms after the pathogenic diagnosis. 60% of asymptomatic cases demonstrated findings of pneumonia on the initial chest CT, including well-recognized features of coronavirus disease-19. […] Two elderly individuals with initially asymptomatic infection developed severe symptoms during hospitalization. […] The epidemiological and clinical findings highlight the significance of asymptomatic infection with SARS-CoV-2. | 2020-06-08 |
| 32492533 | Clinical endpoint was in-hospital death. | 2020-06-05 |
| 32492557 | As the 2019 novel coronavirus disease (COVID-19) continues to spread, some patients are presenting with abdominal symptoms without respiratory complaints. […] Our case series documents four patients who presented with abdominal symptoms whose abdominopelvic CT revealed incidental pulmonary parenchymal findings in the imaged lung bases and were subsequently confirmed positive for COVID-19 via laboratory testing. […] It remains to be seen whether these patients will eventually develop respiratory symptoms. […] While it is possible that the patients’ abdominal complaints are coincidental with CT findings, it is interesting that patients can have such extensive incidental disease in the lungs on CT without respiratory symptoms. | 2020-06-27 |
| 32492562 | Montelukast, which is cheap, safe and widely available would appear to have the potential to be an ideal candidate drug for clinical trials, particularly in early stage disease before irreparable tissue damage has already occurred. | 2020-06-16 |
| 32492721 | It is observed that salivary glands are hosting severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) because of angiotensin-converting enzyme 2 and the detection of high viral loads in the saliva and is playing a crucial role in virus transmission, especially from individuals showing absolutely no symptoms. | 2020-06-03 |
| 32492874 | Because of constraints on resources, frontline healthcare workers may be unable to provide the frequent monitoring and assessment required for all patients at high risk of clinical deterioration. | 2020-06-04 |
| 32492991 | We analyzed the accuracy and clinical usefulness of a point-of-care IgM and/or IgG test for SARS-CoV-2 in 35 COVID-19 patients [12 (34.3%) mild-moderate and 23 (65.7%) severe-critical] admitted to a field hospital in Madrid, as well as in 5 controls. […] The mean time from the first day of symptoms to the antibody test was 28 days (SD: 8.7), similar according to the severity of the disease. | 2020-06-04 |
| 32492995 | The Covid 19 crisis permits to increase the role of Telemedicine as a tool for the delivery of health care services at distance and to slow down the virus diffusion. | 2020-06-04 |
| 32493030 | COVID-19 can be divided into three clinical stages, and one can speculate that these stages correlate with where the infection resides. | 2020-06-04 |
| 32493073 | The symptoms most commonly reported by patients affected by COVID-19 include fever, dry cough, and shortness of breath. […] There were no typical and distinguished symptoms of COVID-19, and she had no risk factor for deep vein thrombosis. […] This case aims to arouse the medical staff’s awareness of deep vein thrombosis as a clinical symptom of COVID-19 even if the patient has no typical symptoms of COVID-19. | 2020-06-12 |
| 32493174 | During the COVID-19 pandemic, the reduced access to our normal clinical teaching highlighted the importance of peer-led teaching sessions. | 2020-06-08 |
| 32493200 | Here we report on the consistent finding of frequent presentation of anosmia or hyposmia in COVID-19 patients, even in the absence of other symptoms and without other olfactory or nasal findings. […] In the uncertainty of the clinical characteristics of these patients, this symptom can be a tool to reduce the spread of the infection between medical population. | 2020-06-08 |
| 32493331 | A comprehensive search of the registered COVID-19 trials has been performed on platforms including ClinicalTrials.gov, WHO International Clinical Trials Registry Platform (WHO ICTRP), Chinese Clinical Trials Registry (CHiCTR), Australian Clinical Trials Registry, Britain’s National Research Register (BNRR), Current Control Trials (CCT), and Glaxo Smith Kline Register. […] In contrast, trials with antiviral drugs have more targeted primary outcomes such as “COVID-19 nucleic acid test” and “28-day mortality.” We provide an evidence mapping and analysis of registered COVID-19 clinical trials in China. […] It is also imperative for multiple public health divisions and research institutions to work together for integrative clinical data capture and sharing, with a common objective of improving future studies that evaluate COVID-19 interventions. | 2020-06-10 |
| 32493370 | Baseline clinical characteristics were compared between patients with stable mild illness (stable mild group) and those who deteriorated from mild to severe illness (progression group). | 2020-06-10 |
| 32493441 | The primary end point is the time to clinical improvement defined as the time from randomization to either an improvement of two points on a six-category ordinal scale measured daily till day 28 or discharge from the hospital or death. […] The trial was registered on Clinical Trials.gov on April 1st, 2020 (ClinicalTrials.gov Identifier: NCT04330638) and on EudraCT on April 3rd 2020 (Identifier: 2020-001500-41). | 2020-06-10 |
| 32493447 | Exclusion criteria include: History of COVID -19 virus infection, clinical symptoms such as fever, nausea, dyspnea and myalgia in the past two months, history of underlying diseases hypersensitivity to hydroxychloroquine and G6PD enzyme deficiency. […] The name of the trial register is Iranian registry of clinical trial (IRCT), registration number is IRCT20120826010664N6, date of trial registration is April 7, 2020, FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). | 2020-06-10 |
| 32493459 | Safety and tolerability of cell administration within first 24 hours of administration; clinical improvement on a seven-category clinical improvement ordinal scale. […] Australian New Zealand Clinical Trials Registry, ACTRN12620000478910, registered 16th April 2020. | 2020-06-10 |
| 32493460 | The study and its outcomes were registered at the German Clinical Trials Register (www.drks.de) on May 12th, 2020, protocol number: #DRKS00021582. | 2020-06-10 |
| 32493466 | Here we estimate the effective reproduction number, Rt, of COVID-19 in Singapore from the publicly available daily case series of imported and autochthonous cases by date of symptoms onset, after adjusting the local cases for reporting delays as of March 17, 2020. | 2020-06-10 |
| 32493468 | This is a single center, open label, randomized, controlled, parallel group, clinical trial that will be conducted at Loghman Hakim Medical Education Center in conjunction with Shahid Beheshti University of Medical Sciences. […] Patients will be randomly assigned to the intervention groups or the control group with the following eligibility criteria: ≥ 18 years of age AND (oxygen saturation (SPO2) ≤ 93% OR respiratory rate ≥ 24) AND at least one of the following: Contactless infrared forehead thermometer temperature of ≥37.8, cough, sputum production, nasal discharge, myalgia, headache or fatigue on admission, and time of onset of the symptoms should be acute (Days ≤ 14). […] Time to clinical improvement is our primary outcome measure. […] We will use Kaplan-Meier to analyze the time to clinical improvement (compared with a log-rank test). […] The present research is open-label (no masking) of patients and health care professionals who are undertaking outcome assessment of the primary outcome - time to clinical improvement. […] Last point of data collection will be the last day on which all of the 60 participants have had an outcome of clinical improvement or death, completing the study’s follow-up time window. […] This study was registered with National Institutes of Health Clinical trials (www.clinicaltrials.gov; identification number NCT04343768, registered April 8, 2020 and first available online April 13, 2020). | 2020-06-10 |
| 32493473 | Secondary objectives are to determine the effects of MSCs on important clinical outcomes, as described below. […] Patients with moderate to severe ARDS as defined by the Berlin definition, receiving invasive mechanical ventilation and with a diagnosis of COVID-19 based on clinical diagnosis or PCR test will be eligible. […] The cell therapy facility and clinical trials pharmacist will be unblinded to facilitate intervention and placebo preparation. […] Other protocol changes in this amendment included an increase in the time of onset of ARDS from 48 to 72 hours, inclusion of clinical outcomes as secondary outcomes, the provision of an option for telephone consent, an indicative sample size and provision to continue recruitment beyond this indicative sample size. […] The study protocol has been reported in accordance with the Standard Protocol Items: Recommendations for Clinical Interventional Trials (SPIRIT) guidelines (Additional file 2). | 2020-06-10 |
| 32493475 | Secondary objectives: To evaluate the efficacy of melatonin as a prophylactic treatment on prevention of asymptomatic SARS-CoV-2 infection.To evaluate the efficacy of melatonin to prevent the development of severe COVID-19 in the participants enrolled in this study who develop SARS-CoV-2 infection along the trial.To evaluate the duration of COVID-19 symptoms in participants receiving melatonin before the infection.To evaluate seroconversion timing post-symptom onset. […] A total of 450 participants are planned to be enrolled in this clinical trial, 225 in the experimental arm and 225 in the placebo arm. […] EU Clinical Trials Register: 2020-001530-35; Date of trial registration: 13th of April 2020; https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001530-35/ES FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). | 2020-06-10 |
| 32493489 | Based on a review of the literature and various guidelines, recommendations are made to mitigate the risk to health care workers of becoming infected with SARS-CoV-2 while providing clinical care. | 2020-06-08 |
| 32493494 | A serological evaluation will be carried out every 15 days with PCR in case of seroconversion, symptoms or risk exposure. […] Some evidence of the in vitro efficacy of hydroxychloroquine against this virus is known, along with some clinical data that would support the study of this drug in the chemoprophylaxis of infection. […] However, there are still no data from controlled clinical trials in this regard. […] 1) Previous infection with SARS CoV2 (positive coronavirus PCR or positive serology with SARS Cov2 negative PCR and absence of symptoms); 2) Current treatment with hydroxychloroquine or chloroquine; 3) Hypersensitivity, allergy or any contraindication for taking hydroxychloroquine, in the technical sheet; 4) Previous or current treatment with tamoxifen or raloxifene; 5) Previous eye disease, especially maculopathy; 6) Known heart failure (Grade III to IV of the New York Heart Association classification) or prolonged QTc; 7) Any type of cancer (except basal cell) in the last 5 years; 6) Refusal to give informed consent; 8) Evidence of any other unstable or clinically significant untreated immune, endocrine, hematological, gastrointestinal, neurological, neoplastic or psychiatric illness; 9) Antibodies positive for the human immunodeficiency virus; 10) Significant kidney or liver disease; 11) Pregnancy or lactation. […] The study protocol has been reported in accordance with the Standard Protocol Items: Recommendations for Clinical Interventional Trials (SPIRIT) guidelines (Additional file 2). | 2020-06-10 |
| 32493514 | Proof of SARS-CoV2 (Symptoms and positive polymerase chain reaction (PCR))2. […] Participation in any other interventional clinical trial within the last 30 days before the start of this trial14. […] The randomisation code will be generated by the CTU (Clinical Trials Unit, ZKS Freiburg) using the following procedure to ensure that treatment assignment is unbiased and concealed from patients and investigator staff. | 2020-06-10 |
| 32493604 | An analysis was made on the influence of this new pathology on the clinical course of AA. […] An evaluation was made of demographic variables, duration of symptoms, type of appendicitis, surgical time, hospital stay, and postoperative complications. […] No differences were found in the time of onset of symptoms or surgical time. | 2020-06-06 |
| 32493671 | COVID-19 occurred in December 2019, as of 30 April 2020, a total of 3,024,059 clinical cases have been reported, including 208,112 deaths. | 2020-06-17 |
| 32493713 | For medical schools, this has manifested as examination and curricular restructuring as well as significant changes to clinical attachments. | 2020-06-27 |
| 32493739 | The primary outcomes were clinical and biological data, imaging and echocardiographic findings, treatment, and outcomes. […] All 21 patients had noticeable gastrointestinal symptoms during the early stage of illness and high levels of inflammatory markers. 19 (90%) had evidence of recent SARS-CoV-2 infection (positive RT-PCR result in 8/21, positive IgG antibody detection in 19/21). […] The clinical outcome was favourable in all patients. […] In this study an unusually high proportion of the affected children and adolescents had gastrointestinal symptoms, Kawasaki disease shock syndrome, and were of African ancestry. | 2020-06-16 |
| 32493814 | The inflammatory response to severe acute respiratory syndrome-related coronavirus 2 infection has a direct impact on the clinical outcomes of coronavirus disease 2019 patients. | 2020-06-04 |
| 32493833 | The clinical and research capacity across the USA is unparalleled, yet compared to other high and even some middle-income countries, the average health indicators of the population remain suboptimal in 2020, a finding at least in part explained by inequity in healthcare access. | 2020-06-24 |
| 32493868 | Dental emergencies are defined through oral symptoms but, the systemic and psychological conditions of each patient should be considered. | 2020-06-26 |
| 32494330 | The combination of symptoms, elevated inflammatory markers, normal baseline pro-B-type natriuretic peptide, PaO2/FiO2 < 300 and positive swab suggested coronavirus disease 2019 (COVID-19) with acute respiratory distress syndrome (ARDS) rather than heart failure exacerbation. | 2020-06-06 |
| 32494532 | She had concurrent complaints of anosmia and ageusia without fever, respiratory symptoms, or obvious risk factors. […] However, it was determined to test the patient for coronavirus disease 2019 (COVID-19) infection despite extremely low clinical suspicion. […] There is currently a lack of published case reports describing COVID-19 patients with the sole symptoms of anosmia and ageusia in the United States of America. | 2020-06-06 |
| 32494546 | To extract and summarize information on potential vaccines and therapeutic agents against COVID-19 at different stages of clinical trials from January to March 2020, we reviewed major clinical trial databases such as ClinicalTrials.gov, WHO International Clinical Trials Registry Platform (ICTRP), and other primary registries between January and March 15, 2020. […] A total of 249 clinical trials were identified between January to March 15, 2020. […] The majority of clinical trials have been conducted on chloroquine (n=10) and traditional Chinese medications (TCMs; n=10), followed by antivirals (n=8), anti-inflammatory/immunosuppressants (n=9), cellular therapies (n=4), combinations of different antivirals therapies (n=3), antibacterial (n=1), and other therapies (n=5). […] Some candidates have been tested for other viral infections and are listed for clinical trials against the COVID-19 pipeline. | 2020-06-06 |
| 32494800 | A patient with diabetes mellitus and hypertension for five years was admitted to the emergency unit with symptoms of fever, cough and dyspnoea. […] These symptoms were consistent with viral pneumonia and a COVID PCR test was performed, which tested positive three days later. | 2020-06-04 |
| 32494854 | These data were derived from the published clinical data in various journals and case reports. | 2020-06-06 |
| 32494931 | Although it seems that antiviral drugs are effective in improving clinical manifestation, there is no definite treatment protocol. | 2020-06-23 |
| 32495030 | During the current COVID-19 pandemic, there is a concrete high risk to see a dramatic worsening of cancer patients’ nutritional status, who are left without adequate clinical and nutritional support. […] Therefore, we believe that it is essential to try to continue, as far as possible, the activity of clinical nutrition in oncology, by revolutionizing the setting and the approach to patients. […] For this purpose, the Clinical Nutrition and Dietetics Unit and the Medical Oncology Unit of our hospital, one of the largest community hospital in Lombardy that has been involved in the COVID-19 outbreak management since its inception, have reorganized the clinical routine activity in strict collaboration since the very beginning of the emergency, to better face up to the challenge, while preserving cancer patients’ needs. | 2020-06-06 |
| 32495141 | The purpose of this study was to develop and validate a prediction model and clinical risk score for Intensive Care Resource Utilization after colon cancer surgery. […] A prediction model for 30-day postoperative Intensive Care Resource Utilization was developed and transformed into a clinical risk score based on the regression coefficients. […] A clinical risk score was developed, and the risk of requiring postoperative Intensive Care Resource Utilization ranged from 0.03 (0 points) to 19.0% (8 points). […] A prediction model and clinical risk score for postoperative Intensive Care Resource Utilization after colon cancer surgery was developed and validated. | 2020-06-06 |
| 32495147 | Detailed data on clinical presentations and outcomes of children with COVID-19 in Europe are still lacking. […] More studies are needed to further understand the presentation and outcomes of children with COVID-19 in children with special needs.What is Known:• There is limited evidence on the clinical presentation and outcomes of children with COVID-19 in Europe, and almost no evidence on characteristics and risk factors of severe cases.What is New:• Among a case series of 130 children, mostly diagnosed at hospital level, and with a relatively high rate (26.2%) of comorbidities, about three-quarter had an asymptomatic or mild disease. | 2020-06-10 |
| 32495299 | COVID-19 largely exhibits mild to moderate clinical manifestations. […] Preclinical studies have reported that angiotensin receptor blockers (ARBs) and ACE inhibitors might increase ACE2 expression in several cell types. […] Although clinical data supporting an influence of all these drugs on the course of the disease are limited, this is an interesting background for further research that might help unravel the complex mechanisms underlying the link between COVID-19 and diabetes. | 2020-06-06 |
| 32495323 | Physical disabilities, cognitive impairment, and mental or psychological distress (e.g., anxiety, depression, and post-traumatic stress disorder) after ICU discharge may be symptoms of PICS, and may continue to affect surviving patients for several years after ICU discharge (Elliott et al., 2014; Held & Moss, 2019; Jackson et al., 2014; Jubran et al., 2010). […] However, post-discharge care for ICU survivors, especially those hospitalized after a sudden onset of severe disease symptoms and then discharged after a long ICU stay or after receiving mechanical ventilation, require specialized care to minimize PICS. | 2020-06-08 |
| 32495332 | The duration of infectiousness of COVID-19 ranges from 1-2 days before and 7-10 days after the onset of symptoms. […] It is often difficult to detect the signs and symptoms of infection and to implement timely intervention during the very early stage of infection. | 2020-06-08 |
| 32495334 | However, people with chronic infectious diseases, carriers with no symptoms, and those likely to be infected are not easy to identify during border screenings. | 2020-06-08 |
| 32495335 | Nursing education includes both classroom teaching and clinical practicum components. | 2020-06-08 |
| 32495368 | Since the first report of cutaneous manifestations of the coronavirus disease 2019 (COVID-19) by Recalcati et al1 , there has been described five clinical patterns including pseudo-chilblain lesions, vesicular eruptions, urticarial lesions, livedo and necrosis and maculopapular eruptions2 . […] Several clinical reports have been published recently describing these clinical patterns although there is still a lack of information regarding histopathology of maculopapular eruptions. […] We collected clinical data and pictures, and performed a biopsy when possible. | 2020-06-19 |
| 32495390 | We want to increase discussion with the scientific community that is directly involved with these animals, because preliminary studies report that NHP may become infected and develop symptoms similar to those in human beings. | 2020-06-19 |
| 32495496 | Clinical, biological and radiological data were collected and analysed. | 2020-06-22 |
| 32495574 | In this paper, we analyzed medical records of 40 patients with coronavirus disease 2019(COVID-19), in order to explore the clinical efficacy of Matrine and Sodium Chloride Injection in the treatment of COVID-19. […] The investigation was based on the results of a previous animal test, which was aimed to investigate and confirme the clinical efficacy of Matrine and Sodium Chloride Injection in the treatment of COVID-19. […] The clinical manifestations, laboratory data, nucleic acid clearance time, and imaging data were compared and analyzed before and after treatment. […] After administration with Matrine and Sodium Chloride Injection, the clinical symptoms of 40 cases were alleviated markedly, and their blood analysis and biochemical indexes returned to normal. […] After administration with Matrine and Sodium Chloride Injection, the symptoms of cough and fatigue were alleviated significantly, and the appetite was significantly improved compared with before, especially for patients with gastrointestinal symptoms. […] The clinical effective rate of 40 cases was 100.0%. […] We believed that Matrine and Sodium Chloride Injection have a good clinical effect in the treatment of COVID-19, and suggested increasing the clinical application and further conducting large-sample-size cli-nical verification. | 2020-06-08 |
| 32495575 | In this study, Donghua Hospital information management system and Meikang clinical pharmacy management system were used to collect medical records of all inpatients diagnosed as coronavirus disease 2019(COVID-19) in Wuhan Third Hospital. […] The statistics was based on the data of the cases treated with Ganlu Xiaodu Decoction, including demographic statistics, clinical cha-racteristics before medication, outcome of after medication and efficacy of drug combination. | 2020-06-08 |
| 32495580 | However, medical workers shall pay attention to drug-induced heart injury in clinical application. […] Based on the guideline from the Diagnosis and Treatment Plans for COVID-19(trial seventh edition), taking the recommended drugs as examples, by Western medicine, traditional Chinese medicine, Chinese herbal injection and integrated traditional Chinese and Western medicine, the study analyzed the basic characteristics of recommended drugs for cardiac injury by means of literature review and bioinformatics methods, and summarized cardiac adverse reactions, toxicity mechanisms, combined pharmacotherapy, special population and drug monitoring, focusing on the clinical manifestations, toxic components, targets and regulatory mechanisms of drug-induced cardiac injury. […] The findings suggested being vigilant to drug-induced cardiac injury during the treatment of COVID-19, playing the advantages of clinical pharmacists and clinical Chinese pharmacists, improving the knowledge reserve of pharmacovigilance, strengthening the prescription review, medication notification and medication monitoring, promoting rational drug use and paying attention to special populations and high-risk groups. | 2020-06-08 |
| 32495581 | High-quality clinical study on traditional Chinese medicine is of great significance to effectively control new public health emergencies represented by outbreaks of infectious diseases and ensure people’s health and safety, but it still faces a series of ethical issues. […] Based on the seven core values of equity, good deeds, effectiveness, respect for individuals, freedom, reciprocity, and solida-rity proposed in the Guidelines for Management of Ethical Issues in Outbreaks of Infectious Diseases, this article emphasizes the characteristics and laws of clinical studies on traditional Chinese medicine. […] Main points of ethical review of traditional Chinese medicine were summarized in the aspects of overall concept, syndrome differentiation and treatment, prevention before disease onset, cultural value, and clinical basis. […] Based on the outbreak of coronavirus disease 2019(COVID-19), we collected relevant registered Chinese medicine clinical studies, summarized the core issues of the ethics review for COVID-19, and further improved the traditional Chinese medicine ethics review system and resources, so as to better serve ethical review and scientific studies in public health emergencies. | 2020-06-08 |
| 32495582 | With the introduction of clinical epidemiological experiment design and evidence-based medicine evidence evaluation into the evaluation of curative effect of traditional Chinese medicine(TCM), TCM has officially entered the studies of syndrome regularity of new public health emergencies(such as SARS and influenza) clearly diagnosed by modern medicine for many years, as well as the development of relevant guidelines, consensus and paths. […] The results of curative effect show that TCM could significantly alleviate symptoms, control disease and tendency, reduce the occurrence of critical illness, and improve the clinical efficacy and the prognosis and quality of life of patients, which fully reflects the consciousness and self-confidence of traditional Chinese medicine workers. […] For the evidence-based evaluation of TCM intervention in new public health emergencies, the basic principles and general methods of clinical epidemiology and evidence-based medicine shall be followed to obtain high-quality evidence; besides, we shall also fully realize that clinical scientific study is carried out with the epidemic treatment as the primary task. […] The scientific hypothesis comes from the clinical problems unsolved. […] The scientific study conclusions aim to give feedbacks to clinical diagnosis and treatment regimens. […] The core elements of clinical trials are population(P), intervention(I), control(C), outcome(O), which are abbreviated as "PICO". […] Then, the selection of patients, the de-finition of intervention measures and control measures, the development of end-point indicators, the clinical quality control under special epidemics, the data verification, and the data analysis methods to be adopted are all characteristics and key points that need special consideration. | 2020-06-08 |
| 32495826 | For patients with COVID-19 symptoms, 92.6% of IBD units referred them to primary care or the emergency department. | 2020-06-26 |
| 32495830 | Relevant clinical and operational leadership from an academic medical center, pediatric teaching hospital, and safety net county health system met to share learnings shortly after deploying inpatient telemedicine. […] Strategic direction from executive leadership, leveraging off-the-shelf hardware, vendor engagement, and clinical workflow integration facilitated rapid deployment. | 2020-06-26 |
| 32495913 | Coronavirus disease 2019 (COVID-19) related coagulopathy may be the first clinical manifestation even in non-vasculopathic patients and is often associated with worse clinical outcomes. […] A 78 years old woman was admitted to the Emergency Unit with respiratory symptoms, confusion and cyanosis at the extremity, in particular at the nose area, hands and feet fingers. […] During hospitalization, the clinical condition worsened and the cyanosis of the nose, fingers, and toes rapidly increased and became dried gangrene in three days. | 2020-06-10 |
| 32495914 | Five patients with COVID-19 accompanied by diarrhea as the main gastrointestinal symptoms were carefully observed through clinical symptoms, imaging and other auxiliary examinations. […] All 5 patients had symptoms of fever and diarrhea upon admission. […] After continuous dynamic follow-up for 3-15 days, no clinical symptoms recurred, and the last nucleic acid test was negative. | 2020-06-10 |
| 32495918 | The aim of this study was to perform a systematic review to compare epidemiological, clinical, and laboratory features of COVID-19 and MERS-COV populations. […] Epidemiology, clinical, and laboratory outcomes, intensive care unit (ICU) admission rates, discharge rates, and fatality rates were evaluated using Graph-Pad Prism software. […] The present study revealed that main clinical manifestations of both COVID-19 and MERS-COV populations are fever, cough and generalized weakness or myalgia, and Acute Respiratory Distress Syndrome (ARDS) is the main complication. […] The main clinical features of both COVID-19 and MERS-COV populations are fever, cough and generalized weakness or myalgia. | 2020-06-10 |
| 32495921 | The most communal symptoms of COVID-19 include fever, cough, and shortness of breath during the incubation period (2-14 days) of infection. […] Search for new specific anti-viral drugs from natural/synthetic origins is under full swing and many of them are currently used as chemotherapeutic drugs under clinical investigation. | 2020-06-10 |
| 32495923 | In this review, we aim to summarize the updated epidemiology, causes, clinical manifestation and diagnosis, as well as prevention and control of the novel coronavirus SARS-CoV-2. […] A broad search of the literature was performed in “PubMed” “Medline” “Web of Science”, “Google Scholar” and “World Health Organization-WHO” using the keywords “severe acute respiratory syndrome coronavirus”, “2019-nCoV”, “COVID-19,”SARS“,”SARS-CoV-2" “Epidemiology” “Transmission” “Pathogenesis” “Clinical Characteristics”. […] We reviewed and documented the information obtained from literature on epidemiology, pathogenesis and clinical appearances of SARS-CoV-2 infection. […] The main clinical presentation of SARS-CoV-2 infection ranges from asymptomatic stages to severe lower respiratory infection in the form of pneumonia. […] There is still much to be understood regarding SARS-CoV-2 about its virology, epidemiology and clinical management strategies; this knowledge will be essential to both manage the current pandemic and to conceive comprehensive measures to prevent such outbreaks in the future. | 2020-06-10 |
| 32495940 | So, whether or not these supplements can prevent or ameliorate COVID-19 associated symptoms is not fully understood. […] The aim of this paper is to provide an indirect evidence about the utility of probiotics in combating COVID-19 or its associated symptoms, through the review of its antiviral and anti-inflammatory properties in vitro, animal models, and human trials. | 2020-06-19 |
| 32495952 | The novel coronavirus disease 2019 (COVID-19) pandemic has resulted in a paradigm shift in disease management. […] While specific data on nail psoriasis treatments and COVID-19 is lacking, we present clinical trial data on rates of upper respiratory infections, nasopharyngitis, viral infection, pneumonia and overall infections. […] Some systemic medications and biologics are associated with increased in infections risk compared to placebo in clinical trials. […] However, this data should be regarded cautiously since clinical trials on nail psoriasis, particularly controlled studies, are lacking. | 2020-06-27 |
| 32495979 | In late December 2019, a group of patients was observed with pneumonia-like symptoms that were linked with a wet market in Wuhan, China. […] Currently, there is no specific approved treatment for SARS-CoV-2, and various clinical trials are underway to explore better treatments. […] Here we summarize the fight against this novel coronavirus with particular focus on the different treatment options and clinical trials exploring treatment as well as work done toward development of vaccines. | 2020-06-19 |
| 32496012 | Medical records of 66 hospitalized COVID-19 patients were collected and classified into non-severe (mild/moderate cases) and severe (severe/critical cases) groups, respectively. | 2020-06-22 |
| 32496100 | Additionally, significant bivariate relationships were found between socially vulnerable respondents (female, Asians, Hispanic, foreign-born, families with children) and fear, as well as with mental health consequences (anxiety and depressive symptoms). […] Depressive symptoms, on average, were high (16+ on the Center for Epidemiologic Studies Depression scale), and more than 25% of the sample reported moderate to severe anxiety symptoms. | 2020-06-04 |
| 32496103 | The Australian Federal Government has promoted digital mental health options for many years, and it has a comprehensive architecture of digital resources in place, but will it be enough to deal with the expected rise in symptoms of trauma among the general population in the wake of COVID-19? | 2020-06-04 |
| 32496123 | With the except of the clinical practice, currently there is no recommendation based on scientific evidence about the use of apheresis in the treatment of ulcerative colitis (UC), and even less in Crohn’s disease (CD). […] However, the results obtained in the case of Pérez et al. in relation to systemic inflammation and pulmonary clinical improvement are very interesting from a pathophysiological and clinical point of view. | 2020-06-18 |
| 32496206 | Our objective was to determine if self-reported symptoms could help monitor the dynamics of the COVID-19 outbreak in France. […] Users were asked questions about underlying conditions, sociodemographic status, zip code, and COVID-19 symptoms. […] Depending on the symptoms reported and the presence of coexisting disorders, users were told to either stay at home, contact a general practitioner (GP), or call an emergency phone number. […] In total, 34.8% (n=1,322,361) reported no symptoms. | 2020-06-17 |
| 32496207 | Although information technology can improve the transferring of such knowledge to clinical practice rapidly, data interoperability is still a challenge due to the heterogeneous nature of hospital information systems. […] Third, searching was executed in the international openEHR Clinical Knowledge Manager (CKM) to find the existing archetypes that could represent the concepts. […] Fifth, a test case of data exchanging between the clinical data repository and clinical decision support system based on the template was conducted to verify the feasibility of the study. | 2020-06-17 |
| 32496236 | Handbills were given with the basic information on the symptoms and what to do in the community. | 2020-06-17 |
| 32496238 | Out of the over 108 efforts, 100 are in preclinical and eight in Phase 1 or 2 trial stage. | 2020-06-17 |
| 32496239 | Several clinical trials worldwide are evaluating several drugs approved for other indications, as well as multiple investigational agents for the treatment and prevention of COVID-19. […] At the time of writing this commentary, there is no peer-reviewed published evidence from randomized clinical trials of any pharmacological agents improving outcomes in COVID-19 patients. […] However, it was reported that remdesivir an investigational antiviral agent hastens clinical recovery, but a study is yet to be published in peer-reviewed medical journal. | 2020-06-17 |
| 32496259 | The information on the clinical course of coronavirus disease 2019 (COVID-19) and its correlates which are essential to assess the hospital care needs of the population are currently limited. | 2020-06-17 |
| 32496284 | We surveyed five Accreditation Council for Graduate Medical Education-accredited orthopaedic residency programs within cities highly affected by the COVID-19 pandemic about clinical and curricular changes. […] One in three reported being unable to obtain institutionally recommended personal protective equipment during routine clinical work. […] Most have shifted schedules to periods of active clinical duty followed by periods of remote work and self-isolation. | 2020-06-16 |
| 32496339 | Hyperlipasemia was not associated with poor outcomes or symptoms. […] Although a mild elevation in serum lipase was observed in some patients with COVID-19, clinical acute pancreatitis was not seen. | 2020-06-16 |
| 32496357 | Solid organ transplant recipients (SOT) comprise a large proportion of this group, yet there is limited knowledge about the presentation, clinical course and immunosuppression management of this novel infection among heart, lung, liver, pancreas and kidney transplant recipients. […] Diagnostic workup, clinical course, immunosuppression/antiviral management and immediate outcomes are described. […] Nearly 43% exhibited GI symptoms. | 2020-06-19 |
| 32496422 | A retrospective cohort study based on propensity score analysis was designed to explore the effects of corticosteroid on several clinical outcomes. 132 patients satisfied the inclusion criteria and 35 pairs were generated according to propensity score matching. | 2020-06-04 |
| 32496587 | Morbidity and mortality from COVID-19 caused by novel coronavirus SARS-CoV-2 is accelerating worldwide and novel clinical presentations of COVID-19 are often reported. | 2020-06-19 |
| 32496707 | The authors present a rehabilitation program including interdisciplinary care with simple and reproducible clinical criteria. | 2020-06-09 |
| 32496715 | Results of analysis of phylogenetic, virological, epidemiological, ecological, clinical data of COVID-19 outbreaks in Wuhan, China (PRC) in comparison with SARS-2002 and MERS-2012 outbreaks allow to conclude: - the etiological agent of COVID-19 is coronavirus (2019-CoV), phylogenetically close to the SARS-CoV, isolated from human, and SARS-related viruses isolated from bats (SARS-related bat CoV viruses). | 2020-06-17 |
| 32496723 | This review, written with the emergency medicine clinician in mind, describes the epidemiology, clinical features, and management implications for COVID-19 in pediatric patients. | 2020-06-17 |
| 32496734 | The clinical studies have shown that advanced age and chronic diseases increase the risk of infection. […] The aim of this study is to investigate whether there exists a relationship between the blood groups of the patients and risk of SARS-CoV-2 infection and the clinical outcomes in COVID-19 patients. 186 patients with PCR confirmed diagnosis of COVID-19 were included in this study. […] The blood group types did not affect the clinical outcomes. […] However, once infected, blood group type does not seem to influence clinical outcome. | 2020-06-04 |
| 32496872 | COVID-19 is a new clinical syndrome characterized by respiratory symptoms with variable degrees of severity, from mild upper respiratory illness to severe interstitial pneumonia and acute respiratory distress syndrome aggravated by thrombosis in pulmonary microcirculation. | 2020-06-11 |
| 32496926 | Several clinical studies showed that CQ/HCQ alone or in combination with a macrolide may alleviate the clinical symptoms of COVID-19, promote viral conversion, and delay disease progression, with less serious adverse effects. | 2020-06-22 |
| 32496938 | While the COVID-19 epidemic occurred since December 2019, as of end April 2020, no treatment has been validated or invalidated by accurate clinical trials. […] As opinions, politics, media and beliefs are governing COVID-19 therapy, performance of randomised controlled blinded clinical trials became difficult. […] Results of sound clinical trials are eagerly awaited. | 2020-06-12 |
| 32497031 | Transmission of symptomatic COVID-19 was successfully limited using strategies of quarantine, social distancing, early screening of trainees, rapid isolation of persons with suspected cases, and monitored reentry into training for trainees with positive test results after resolution of symptoms. | 2020-06-05 |
| 32497090 | Data in relation to clinical presentation, investigation were maternal and neonatal outcomes were extracted and analysed using summary statistics. […] COVID-19-positive pregnant women present with fewer symptoms than the general population and may be RT-PCR negative despite having signs of viral pneumonia. | 2020-06-10 |
| 32497168 | In under 6 months, since SARS-CoV-2 was identified, the massive international effort to develop a SARS-CoV-2 vaccine has generated more than 140 vaccines in different stages of development with 9 already recruiting into clinical trials posted on clinicaltrials.gov. | 2020-06-26 |
| 32497191 | Gastrointestinal symptoms are common in COVID-19 patients, and SARS-CoV-2 RNA has been detected in stool specimens. | 2020-06-26 |
| 32497196 | The urgent needs for exploring the neutralizing antibodies from patients with different clinical characteristics are emerging. […] The dynamics of neutralizing antibody levels at different time points with different clinical characteristics were analyzed. […] Patients with a worse clinical classification had a higher neutralizing antibody titer (β=0.4639, P=0.0227). | 2020-06-26 |
| 32497212 | We enrolled quarantined people with RT-PCR-confirmed SARS-CoV-2 infection, collecting clinical data, travel and contact history, and saliva at enrolment and daily nasopharyngeal throat swabs (NTS) for RT-PCR testing. […] Of these, 30 participated in the study: 13(43%) never had symptoms and 17(57%) were symptomatic. 17(57%) participants acquired their infection outside Vietnam. | 2020-06-26 |
| 32497257 | It has fatality rate that floats from 5 to 15% and the symptoms are fever, cough, myalgia and/or fatigue up to dyspnea, responsible for hospitalization and in most of the cases of artificial oxygenation. […] Our attention has been focused on the role of ACE2 in that its blockade by the virus increases Bradykinin and its metabolites, well known to facilitate inflammation in the lung (responsible for cough and fever), facilitate both the coagulation and complement system, three mechanisms that are typical of angioedema, cardiovascular dysfunction and sepsis, pathologies which symptoms occur in COVID-19 patients. | 2020-06-19 |
| 32497283 | Both viruses have similar transmission characteristics and common clinical manifestations. […] Increasing experience in thoracic radiology may contribute to diagnose the responsible virus(es) from the clinical illness. | 2020-06-04 |
| 32497297 | Epidemiological, demographic and clinical features, and inflammatory indexes were collected and compared between males and females. | 2020-06-19 |
| 32497298 | Despite respiratory symptoms are typically found during the course of coronavirus disease 2019 (COVID-19), gastrointestinal manifestations are increasingly described. | 2020-06-19 |
| 32497344 | This case report presents a 41-year-old male COVID-19 patient who had petechiae and purpura as the referral symptoms. | 2020-06-19 |
| 32497413 | The experts used their clinical judgment to make final decisions on the linkages selected in this study. […] NANDA-I, NOC and NIC linkages identified in this manuscript provide resources to support clinical decisions and care plan development for nurses practicing in the community. | 2020-06-19 |
| 32497535 | Several specific anti-inflammatory/immunosuppressive agents are being evaluated by ongoing clinical trials; however, there is currently insufficient evidence for their efficacy and safety in COVID-19 treatment. […] Therefore, randomized clinical trials of PDE4 inhibitors are necessary to explore their potential therapeutic effect as an adjunct to supportive measures and other therapeutic regiments. | 2020-06-27 |
| 32497632 | The ongoing clinical trials both with respect to drug repurposing and vaccines are summarized along with a brief description. | 2020-06-28 |
| 32497662 | Much is being learned about clinical outcomes for adult COVID-19 patients with underlying chronic conditions; however, there is less coverage on how the COVID-19 pandemic impacts the management of chronic medical conditions, such as asthma, in children and youth. | 2020-06-12 |
| 32497745 | One hundred and six patients had regular clinical follow-ups, while 45 were managed through telemedicine. | 2020-06-28 |
| 32497778 | In particular, our work highlights opportunities for clinical trials with existing or under development rheumatoid arthritis and other (e.g. | 2020-06-06 |
| 32497796 | Specific coagulation and inflammatory markers (D-dimer, ferritin, and C-reactive protein), along with the clinical picture, triggered the trial of recombinant tissue plasminogen activator (rt-PA) and tocilizumab. | 2020-06-28 |
| 32497806 | For infections of global importance including emerging pandemics such as COVID-19 or prevalent endemic diseases such like dengue, identifying patients at risk of severe disease and clinical deterioration can be challenging given the majority present with a mild illness. […] Finally, we propose a set of essential criteria for the roll-out of wearable technology for clinical use. | 2020-06-06 |
| 32497809 | The evaluated RDT showed a high sensitivity and specificity in samples mainly obtained during the first week of symptoms and with high viral loads, despite the use of a non-validated sample material. | 2020-06-06 |
| 32497810 | There are several randomised clinical trials of masks and respirators, but most used clinical endpoints or tested only for influenza. […] More clinical trials are needed to assess the efficacy of respiratory protection against coronavirus infections. | 2020-06-06 |
| 32497812 | Our results also suggest that asymptomatic and subclinical infections constitute a substantial component of the COVID-19 morbidity burden. | 2020-06-28 |
| 32497913 | Management decisions should rely on the clinical assessment for the probability of ongoing myocardial ischemia, as well as alternative nonischemic causes of injury, integrating the level of suspicion for COVID-19. | 2020-06-26 |
| 32497963 | With restrictions on face to face clinical consultations in the COVID-19 pandemic and the challenges faced by health care systems in delivering patient care, alternative information technologies like telemedicine and smartphone are playing a key role. | 2020-06-26 |
| 32497969 | To investigate anxiety, stress, and depression levels of physicians during the Covid-19 outbreak and explored associated factors in both clinical and general site. […] Of all 442 participants, 286 (64.7%) had symptoms of depression, 224 (51.6%) anxiety, and 182 (41.2%) stress. | 2020-06-23 |
| 32498065 | All 3 had ill contacts in the home or had been to the pediatrician and presented with mild to moderate symptoms including fever, rhinorrhea, and hypoxia, requiring supplemental oxygen during their hospital stay. | 2020-06-04 |
| 32498081 | The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has important implications for the safety of participants in clinical trials and the research staff caring for them and, consequently, for the trials themselves. […] Patients with heart failure may be at greater risk of infection with COVID-19 and the consequences might also be more serious, but they are also at risk of adverse outcomes if their clinical care is compromised. […] As physicians and clinical trialists, it is our responsibility to ensure safe and effective care is delivered to trial participants without affecting the integrity of the trial. […] Many regulatory authorities from different world regions have issued guidance statements regarding the conduct of clinical trials during this COVID-19 crisis. […] Accordingly, the Heart Failure Association of the European Society of Cardiology on 21 and 22 March 2020 conducted web-based meetings with expert clinical trialists in Europe, North America, South America, Australia, and Asia. […] The main objectives of this Expert Position Paper are to highlight the challenges that this pandemic poses for the conduct of clinical trials in heart failure and to offer advice on how they might be overcome, with some practical examples. […] While this panel of experts are focused on heart failure clinical trials, these discussions and recommendations may apply to clinical trials in other therapeutic areas. | 2020-06-22 |
| 32498085 | Appropriate glycemic management contributes to a reduction in adverse clinical outcomes in acute illness but also requires intensive patient interactions for bedside glucose monitoring, intravenous and subcutaneous insulin administration, as well as rapid intervention for hypoglycemia events. | 2020-06-26 |
| 32498131 | As large numbers of candidate drugs and vaccines for potential use in the Covid-19 pandemic are investigated, medicines regulators globally must now make urgent, informed, contextually risk-based decisions regarding clinical trials and marketing authorizations. | 2020-06-19 |
| 32498135 | Measures included demographics, comorbidities, clinical presentation, laboratory values and imaging on admission. | 2020-06-22 |
| 32498230 | Indeed, important differences have been reported between the measures employed to treat ACS in China during the first disease outbreak and what currently represents clinical practice across Europe and the USA. | 2020-06-05 |
| 32498267 | Increases in negative affect and symptoms of anxiety and depression (p-values < 0.001) were observed after 2 weeks of confinement. | 2020-06-22 |
| 32498376 | Distinctive clinical features of severe COVID-19 include acute respiratory distress syndrome, neutrophilia, and cytokine storm, along with severe inflammatory response syndrome or sepsis. | 2020-06-11 |
| 32498401 | Variables considered were sociodemographic variables, physical symptoms, health conditions, COVID-19 contact history and psychological adjustment. […] The predictive variables with the highest weight were sex (OR = 1.952, 95% IC = (1.667, 2.286)), presence of symptoms (OR = 1.130, 95% CI = (1.074, 1.190)), and having had close contact with an individual with confirmed COVID-19 (OR = 1.241, 95% CI = (1.026, 1.500)). | 2020-06-22 |
| 32498493 | Case fatality reflects the therapeutic effect of clinical intervention. […] However, the case fatality in Wuhan has being kept the highest in China, indicating that clinical treatment for this virus-caused emerging infectious disease, whose pathogenesis remains to be elucidated, had a limited effect in controlling this epidemic. […] Recently, profit-seeking mechanism run in Chinese health service system disorganized the balance of clinical service and public health service patterns in China, promoting the vicious circle of “attaching importance to clinical treatment and despising disease prophylaxis” , damaging the infrastructure of public health capacity, thus contributing to the formation of the inevitability in various fortuities of public health emergency. […] Second, the vicious circle of profit-seeking-caused “attaching importance to clinical treatment and despising disease prophylaxis” should be immediately broken to optimize the national health service system in China by increasing the investment in public health service. | 2020-06-05 |
| 32498503 | This novel community health trouble is frightening the universe with clinical, psychological, emotional, collapse of health system and economical slowdown in each and every part of the world infecting nearly 200 countries. […] The symptoms vary from asymptomatic, low grade pyrexia, dry cough, sore throat, breathlessness, tiredness, body aches, fatigue, myalgia, nausea, vomiting, diarrhea, to severe consolidation and pneumonia, acute respiratory distress syndrome (ARDS) and multiple organ dysfunction leading to death with case fatality rate ranging from 2 to 3%. | 2020-06-09 |
| 32498691 | While these symptoms arise acutely during the course of infection, less is known about the possible long-term consequences for the brain. […] This article summarizes the current understanding of neurological symptoms of COVID-19 and hypothesizes that affected patients may be at higher risk of developing cognitive decline after overcoming the primary COVID-19 infection. | 2020-06-17 |
| 32498725 | During the 2020 COVID-19 pandemic, open science has become central to experimental, public health, and clinical responses across the globe. | 2020-06-06 |
| 32498749 | The novel 2019 coronavirus outbreak that first appeared in Wuhan has quickly gained global attention, due to its high transmissibility and devastating clinical and economic outcomes. | 2020-06-25 |
| 32498762 | A comprehensive search using the PubMed database was carried out to summarize the latest published information about the epidemiology, definition, pathogenesis, clinical characteristics, treatment options, prognosis and prevention of coronavirus disease 2019. […] Transmission occurs essentially through the respiratory tract and the main symptoms are fever, cough and dyspnea. […] Diagnosis is based on epidemiological, clinical and imaging features and confirmed by nucleic acid testing. | 2020-06-05 |
| 32499073 | Clinical manifestations of COVID-19 in children are milder, but the real burden of disease is unknown. | 2020-06-08 |
| 32499154 | This review provides insight into our prevalent perception of coronavirus-host interactions, structure of SARS-CoV2, receptor mediated entry of virus inside the human cells, ongoing clinical trials, drug therapies and treatments that are being used to combat COVID-19 targeting viral fusion, replication and its multiplication. | 2020-06-08 |
| 32499159 | There is little information about community pharmacists’ on occupational exposure, symptoms development, and testing practices in the community pharmacist cohort. | 2020-06-08 |
| 32499169 | The preventive screening protocol consisted of nasopharyngeal swabs (NPS) for all patients and physicians with symptoms and for unprotected contact infected cases, and serological physician evaluations every 15 days. | 2020-06-08 |
| 32499176 | In addition to pulmonary symptoms, gastrointestinal symptoms have been increasingly recognized as part of the disease spectrum. | 2020-06-08 |
| 32499212 | This is particularly important for COVID-19, where many individuals are asymptomatic or have only mild symptoms but can still spread the disease. […] Current systems for controlling transmission rely on patients to report their symptoms to medical professionals and be able to recall and trace all their contacts from the previous few days. | 2020-06-17 |
| 32499303 | Based on a National Institute of Health (NIH)-endorsed Protocol to research Patient Experience of COVID-19, we collected longitudinal severity scores of five symptoms (cough, shortness of breath, fatigue, headaches and anosmia) and general unwellness on a four-point ordinal scale modelled on performance status scoring. […] All patients reported marked improvements of disease related symptoms after starting famotidine. | 2020-06-24 |
| 32499314 | A bibliographic search was performed in Pubmed on the immune response to the disease, and in ClinicalTrials.gov on clinical trials with interleukin 6 blockers. | 2020-06-05 |
| 32499385 | At present, there is no compelling data showing that NSAIDs worsen the severity of COVID-19 symptoms or increase one’s likelihood of contracting the illness. […] For patients in pain and without symptoms that could potentially be attributed to COVID-19 (cough, fevers/chills, lethargy, myalgias, anosmia and so on), NSAIDs should continue to remain a viable option to provide analgesia to patients in need. | 2020-06-05 |
| 32499448 | Information about the clinical characteristics and mortality of patients with coronavirus disease 2019 at different ages is limited. […] The symptoms of the elderly patients were more atypical, with more comorbidities, secondary infection, organ injuries, immune dysfunction and a higher risk of critical illness. […] The clinical symptoms, first laboratory results, CT findings, organ injuries, disease severity and mortality were analyzed. | 2020-06-26 |
| 32499832 | To date, clinical evidence and guidelines based on reliable data and randomized clinical trials for the treatment of COVID-19 are lacking. | 2020-06-07 |
| 32499983 | The mean incubation period is 5.1 days, and infected individuals can exhibit a variety of symptoms from fever, cough, dyspnea, and respiratory failure to even multiorgan failure. […] In this review, we discuss the background, epidemiology, possible pathophysiology, clinical presentation, and diagnostic studies related to SARS-CoV-2 infection. | 2020-06-07 |
| 32500116 | Significant investment has been made to support enhanced surveillance at point of entry and hospitals, infection control practices, clinical case management, and clinical research. | 2020-06-07 |
| 32500134 | Several guidelines to guide clinical practice among esophagogastric surgeons during the COVID-19 pandemic were produced. | 2020-06-26 |
| 32500326 | COVID-19 displays a variety of clinical manifestations; in pauci-symptomatic patients olfactory (OD) and gustatory dysfunctions (GD) may represent the first or only symptom. | 2020-06-08 |
| 32500327 | This manuscript highlights the importance of endoscopy in daily ENT clinical practice, which is a pivotal procedure in the diagnosis of many head and neck pathologies. | 2020-06-08 |
| 32500409 | Although the infection is mild in most of the affected individuals, it may cause severe clinical manifestations such as acute respiratory distress syndrome or cytokine storm leading to death. | 2020-06-26 |
| 32500432 | It should be implemented the number of health workers, equipment, and spaces dedicated to performing colonoscopy for screening purpose and in subjects with alarm symptoms in the shortest time. | 2020-06-08 |
| 32500509 | Real-time reverse-transcription polymerase chain reaction (RT-PCR) demonstrated a low sensibility; therefore chest computed tomography (CT) plays a pivotal role not only in the early detection and diagnosis, especially for false negative RT-PCR tests, but also in monitoring the clinical course and in evaluating the disease severity. | 2020-06-25 |
| 32500518 | The need for urgent intervention is evaluated on a case-by-case basis according to the severity of the symptoms, the likelihood of progression, and global clinical judgment. | 2020-06-25 |
| 32500526 | In case of an active SARS-CoV-2 infection, biological treatment needs to be stopped until clinical recovery and SARS-CoV-2 negativity is established and treatment with biologicals should be re-initiated. | 2020-06-19 |
| 32500549 | This review article presents a comprehensive analysis of the current data in relation to COVID-19 and its effect on pregnant women, including symptoms, disease severity and the risk of vertical transmission. […] The most common reported symptoms are fever, cough, shortness of breath and diarrhea. | 2020-06-19 |
| 32500586 | Dental education uniquely blends didactic courses and hands-on clinical training seamlessly to prepare oral healthcare providers of the future. […] In spite of those efforts, since clinical experiences cannot be completely replaced by any available alternative method of instruction that is delivered remotely, students are missing out on valuable patient-based clinical experiences. | 2020-06-19 |
| 32500642 | However, although we agree that the clinical picture is original, we reject that “varicella-like” denomination since clinical presentation, as well as some histologic features that we wish to report here for the first time, make it clearly different from varicella. | 2020-06-19 |
| 32500648 | Although the skin is not the main target of the SARS CoV-2 infection, it is strongly involved both directly and indirectly, in many aspects of dermatological disease management, and particularly in pediatric dermatology. | 2020-06-19 |
| 32500666 | Yet immunocompromised status alone, in the absence of other comorbidities, may not necessarily predict severe illness presentations and poorer clinical outcomes as indicated by recent reports of COVID-19-infected solid organ transplant recipients and people living with human immunodeficiency virus (HIV). | 2020-06-19 |
| 32500700 | All patients underwent CT examination and a total CT score and the number of involved lung lobes were calculated and compared against collected laboratory and clinical information. […] Univariable and multivariate proportional hazards analysis were used to determine the relationship between the CT, laboratory and clinical data and ICU admission and in-hospital death. | 2020-06-05 |
| 32500793 | The international scientific community, following World Health Organization (WHO) indications, launched different trials for testing drugs putatively able to block the SARS-CoV-2 infection or treat the COVID-19 disease symptoms. | 2020-06-05 |
| 32500852 | However, there is lack of clinical evidence on the effectiveness of these walkthrough gates to contain COVID-19. | 2020-06-05 |
| 32500951 | We describe the measures taken in a tertiary hospital in Singapore to mitigate the risk of infection in the outpatient setting while ensuring that continuing clinical care of patients with chronic diseases is not compromised. | 2020-06-19 |
| 32501133 | Amidst all the havoc, one interesting observation in the present COVID-19 pandemic is the negligible symptoms in the young; particularly children below 10 years of age. | 2020-06-05 |
| 32501190 | Early data on COVID-19 suggest heterogeneity in the severity of symptoms during transmission and infection ranging from no symptoms to death. […] Demographic and clinical comorbidities associated with the severity of infection suggest that possible variants known to influence the renin-angiotensin-aldosterone system pathway (particularly those that influence ACE2) may contribute to the heterogenous infection response. | 2020-06-05 |
| 32501293 | Background Identifying immune correlates of COVID-19 disease severity is an urgent need for clinical management, vaccine evaluation and drug development. | 2020-06-05 |
| 32501330 | For some, covid-19 is fatal, but others have no symptoms at all. | 2020-06-08 |
| 32501363 | An illustrative example of medicine selection for the patients with mild symptoms of the COVID-19 is provided to show the effectiveness of the proposed method. | 2020-06-26 |
| 32501382 | In this article, we provide a brief review for Orthopedic surgeons as regard COVID-19 virus microbiology, epidemiology, clinical picture, and diagnosis. | 2020-06-08 |
| 32501397 | One of the striking features of infection is the heterogeneous clinical response with worse outcomes observed in older patients and those with underlying health conditions. […] Cytomegalovirus (CMV), a persistent herpesvirus infection whose prevalence increases with age, is a major modulator of immune function and several observations suggest that infection might act to influence clinical outcome following SARS-CoV-2 infection. […] This review addresses mechanisms by which cytomegalovirus infection may act to worsen the clinical outcome of SARS-CoV-2 infection, discusses how these potential links could be investigated, and assesses the potential significance of any findings that emerge. | 2020-06-08 |
| 32501411 | Our data display excellent IgG/IgM specificities for all the immunocromatographic card tests (100% IgG and 100% IgM) and for the chemiluminescence-automated assay (100% IgG and 94% IgM); IgG/IgM sensitivities are moderately lower for all methods, probably due to the assay viral antigen’s nature and/or to the detection time of nasopharyngeal swab RT-qPCR, with respect to symptoms onset. | 2020-06-08 |
| 32501454 | We compared survival, mechanical ventilation-free survival, changes in C-reactive protein, respiratory function, and clinical status in a cohort of patients who received additional treatment with anakinra (either 5 mg/kg twice a day intravenously [high dose] or 100 mg twice a day subcutaneously [low dose]) with a retrospective cohort of patients who did not receive anakinra (referred to as the standard treatment group). […] A further seven patients received low-dose subcutaneous anakinra in addition to non-invasive ventilation and standard treatment; however, anakinra treatment was interrupted after 7 days because of a paucity of effects on serum C-reactive protein and clinical status. […] In this retrospective cohort study of patients with COVID-19 and ARDS managed with non-invasive ventilation outside of the ICU, treatment with high-dose anakinra was safe and associated with clinical improvement in 72% of patients. | 2020-06-08 |
| 32501511 | To support pediatric clinical studies for investigational treatments of coronavirus disease 2019 (COVID-19), pediatric-specific dosing is required. | 2020-06-13 |
| 32501535 | Using sequence-independent single-primer amplification and nanopore whole-genome sequencing, we have found that the nonstructural protein 1 (nsp1) gene, located at the 5’ end of the SARS-CoV-2 genome, was highly expressed in the nasopharyngeal or saliva specimens of 9 COVID-19 patients of different clinical severity. […] Validation with 101 clinical specimens showed that our nsp1 RT-PCR assay has a sensitivity of 93.1% (95% confidence interval [CI]: 86.2%-97.2%), which was similar to those of N and E gene RT-PCR assays. | 2020-06-19 |
| 32501538 | Clinical indexes of patients upon admission/discharge were examined. | 2020-06-24 |
| 32501731 | Patients with metabolic-associated preconditions such as hypertension, obesity and diabetes are susceptible to experience severe symptoms. […] However, this clinical manifestation has been unintentionally underestimated by physicians and scientific communities. […] In this mini-review, we summarize the metabolic and vascular manifestations of COVID-19 with an emphasis on the association between changes in LDL-c levels and the development of severe symptoms as well as the pathophysiologic mechanisms underlying the synergistic effect of LDL-c and SARS-CoV-2 on EC injuries and vasculopathy. | 2020-06-05 |
| 32501747 | Patients were followed through the platform with daily control of symptoms and vital signs. | 2020-06-05 |
| 32501802 | The system will then automatically send a message to the contacts informing them of their contact status, what this status means, the actions that should follow (eg, self-quarantine, respiratory hygiene/cough etiquette), and advice for receiving early care if they develop symptoms. | 2020-06-25 |
| 32501804 | Social media platforms such as Twitter and Google Trends analyses are highly beneficial to model pandemic trends as well as to monitor the evolution of patients’ symptoms or public reaction to the pandemic over time. | 2020-06-23 |
| 32501805 | The prevalence of stress, anxiety, and depressive symptoms; the demographic correlates of the same; and the outcomes of the Text4Hope intervention in mitigating distress will be evaluated. […] Self-administered anonymous online questionnaires will be used to assess stress (Perceived Stress Scale), anxiety (Generalized Anxiety Disorder-7 scale [GAD-7]), and depressive symptoms (Patient Health Questionnaire-9 [PHQ-9]). […] Data analysis will include parametric and nonparametric techniques, focusing on primary outcomes (ie, stress, anxiety, and depressive symptoms) and metrics of use, including the number of subscribers and user satisfaction. […] This COVID-19 project will provide key information regarding prevalence rates of stress, anxiety, and depressive symptoms during the pandemic; demographic correlates of distress; and outcome data related to this scalable population-level intervention. | 2020-06-23 |
| 32501807 | We evaluated its clinical sensibility and pilot tested the instrument. | 2020-06-25 |
| 32501809 | Amid the coronavirus disease (COVID-19) crisis, we have witnessed true physicianship as our frontline doctors apply clinical problem-solving to an illness without a textbook algorithm. […] We need a preclinical system designed to steer early learners from “know” to “know how.” Education leaders have long advocated for such changes to the medical school structure. | 2020-06-24 |
| 32501876 | The clinical symptoms of COVID-19 patients include fever, cough, and fatigue. […] Gastrointestinal symptoms (diarrhea, anorexia, and vomiting) may be present in 50% of patients and may be associated with worst prognosis. | 2020-06-05 |
| 32501877 | COVID-19 related liver enzyme elevations have been described however the clinical presentation, enzyme kinetics, and associated laboratory abnormalities of these patients have not been well described. […] However, the clinical course of COVID-19 related liver injury appears benign. | 2020-06-19 |
| 32501972 | Our study aims to systematically present the clinical evidence of LHQWG in treating COVID-19, which will be of significant meaning for further research and clinical practice. | 2020-06-16 |
| 32502005 | The Web of Science, PubMed, The Cochrane Library, EMBASE and Clinical Trials will be electronically searched to collect randomized controlled trials regarding the efficacy of masks for influenza in the community through Apr 2020. | 2020-06-16 |
| 32502008 | Secondary outcomes were accompanying symptoms (such as myalgia, expectoration, stuffiness, runny nose, pharyngalgia, anhelation, chest distress, dyspnea, crackles, headache, nausea, vomiting, anorexia, diarrhea) disappear rate, negative COVID-19 results rate on 2 consecutive occasions (not on the same day), average hospitalization time, clinical curative effect, and improved quality of life. | 2020-06-16 |
| 32502117 | Symptoms are usually less severe in children than in adults. […] Clinical physicians should be alert to asymptomatic children with COVID-19. | 2020-06-16 |
| 32502128 | A 17-year-old obese male was admitted to the pediatric intensive care unit after presenting with fluid-responsive septic shock following 7 days of fever, gastrointestinal symptoms and neck pain. | 2020-06-05 |
| 32502132 | As updates and modifications in the management of COVID-19 are still evolving, local guidelines, appraised at regular intervals, are vital in optimizing clinical management. | 2020-06-16 |
| 32502282 | In the setting of the novel 2019 coronavirus (COVID-19) pandemic, it has been challenging to provide medical students in the Emergency Medicine (EM) clerkship meaningful clinical experiences that would meet clinical course goals and objectives, as well as satisfy Liaison Committee for Medical Education (LCME) requirements. […] The authors present a novel clinical educational experience for senior medical students in an EM clerkship that fulfills specific clinical course learning objectives, while still providing students the opportunity to interact live with patients. […] We designed a virtual clinical experience where students performed supervised ‘virtual callbacks’ for patients recently evaluated in the ED. […] Completing the COVID-19 callbacks decreased some of the clinical burden on the department. | 2020-06-19 |
| 32502331 | Within this large-scale study, we compared clinical symptoms, laboratory findings, radiographic signs, and outcomes of COVID-19, SARS, and MERS to find unique features. […] Clinical outcomes and findings would be biased by reporting only confirmed cases, and this should be considered when interpreting the data. | 2020-06-19 |
| 32502389 | We projected a median unmitigated burden of 23 million (95% prediction interval 13-30) clinical cases and 350 000 deaths (170 000-480 000) due to COVID-19 in the UK by December, 2021. | 2020-06-08 |
| 32502594 | A group of approved panelists developed key clinical questions by using the PICO (Population, Intervention, Comparator, Outcome) format that addressed urgent clinical questions regarding the prevention, diagnosis, and treatment of VTE in patients with COVID-19. | 2020-06-26 |
| 32502645 | Symptomatology and duration were extracted from routinely collected clinical data and follow-up telephone consultations. […] The median onset of anosmia in relation to onset of SARS-CoV-2 disease (COVID-19) symptoms (as defined by the Public Health England case definition) was 4 days (interquartile range (IQR) 5). […] Median duration of COVID-19 symptoms in community patients was 10 days (IQR 8) versus 18 days (IQR 13.5) in admitted patients. […] As of April 1, 45 patients had ongoing COVID-19 symptoms and/or anosmia; 107/141 (76%) patients had household contacts, and of 185 non-tested household contacts 79 (43%) had COVID-19 symptoms with 46/79 (58%) reporting anosmia. | 2020-06-25 |
| 32502646 | Patients presenting to a Dutch teaching hospital were eligible between 17 March and 10 April 2020, when they had respiratory symptoms that were suspected for COVID-19. […] Sensitivity increased to 31/52 (60%; 95% CI 46%-73%) in patients with at least 7 days of symptoms, and to 21/33 (64%; 95% CI 47%-80%) in patients with C-reactive protein (CRP) ≥100 mg/L. […] Sensitivity and specificity of Wantai SARS-CoV-2 Ab ELISA was 59/95 (62%; 95% CI 52%-72%) and 125/128 (98%; 95% CI 95%-100%) in all patients, respectively, but sensitivity increased to 38/48 (79%; 95% CI 68%-91%) in patients with at least 7 days of symptoms. […] Sensitivity improved in patients with longer existing symptoms or high CRP. | 2020-06-12 |
| 32502882 | DESIGN: BRACE CORONA is a pragmatic, multicenter, randomized, phase IV, clinical trial that aims to enroll around 500 participants at 34 sites in Brazil. […] SUMMARY: BRACE CORONA will evaluate whether the strategy of continued ACEI/ARB therapy compared with temporary discontinuation of these drugs impacts clinical outcomes among patients with COVID-19. | 2020-06-26 |
| 32503061 | Compared to the pathognomonic symptoms of the named disease, homeopathic symptoms are always more helpful for homeopathic prescriptions. […] This study reports and summarizes the homeopathic symptoms observed in 18 confirmed/suspected epidemiologically related cases in cluster outbreaks of COVID-19 in Hong Kong in early 2020. […] Homeopathic symptoms from this case series were collected from 18 consecutive patients who, in addition to their concurrent conventional treatment or traditional Chinese medicine, actively sought help from homeopathy as an adjunctive measure for symptomatic relief from COVID-19. […] Cases were categorized according to outbreak clusters, focusing mainly on the homeopathic symptoms. […] In the analysis, frequency of all homeopathic medicines, common rubrics in all the cases, common rubrics in each of the top-ranked remedies, and differentiating symptoms for each top-ranked remedy were determined. […] Homeopathic symptoms of 18 cases, each identified as mild and belonging to one of six separate clusters, are reported. […] Eighteen common symptoms screened out of 79 selected rubrics constituted two sets of homeopathic symptom pictures: Bryonia alba (n = 4) and Gelsemium sempervirens (n = 12). […] The common symptoms of 18 mild COVID-19 cases constituted two sets of homeopathic symptom pictures, indicating Bryonia alba or Gelsemium sempervirens; they were indicated in 4 and 12 cases, respectively, out of the 18 in total. | 2020-06-06 |
| 32503062 | This should be done through performance of impeccably controlled, prospective, randomized clinical trials, with publication of their findings in well-ranked conventional medicine journals. | 2020-06-05 |
| 32503084 | Most of the cases were mild or moderate with typical signs and symptoms. | 2020-06-19 |
| 32503088 | We systematically reviewed available evidence for reports of neurological signs and symptoms in Coronavirus disease (COVID)-19 patients to identify cases with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection or immune-mediated reaction in the nervous system. […] The reports focused on smell and taste (n=5) and evaluation of neurological symptoms and signs in cohorts (n=5). […] This systematic review failed to establish comprehensive insights to nervous system manifestations of COVID-19 beyond immune-mediated complications as aftermath of respiratory symptoms. […] The authors therefore provide guidance for more careful clinical, diagnostic and epidemiological studies to characterize the manifestations and burden of neurological disease caused by SARS-CoV-2 on behalf of the Infectious Disease Panel of the European Academy of Neurology. | 2020-06-19 |
| 32503092 | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was confirmed through clinical evaluation by a panel of experts in conjunction with chest CT and viral RNA detection. | 2020-06-11 |
| 32503140 | In the absence of clinical data on Human T leukaemia Type 1 and COVID-19 infection, we are providing guidance to clinicians who look after people living with HTLV-1. | 2020-06-08 |
| 32503172 | This study aimed to investigate the impact of the COVID-19 pandemic on ASD individuals, whether any pre-pandemic sociodemographic or clinical characteristics would predict a negative outcome, and to narratively characterize their needs. […] Parents and guardians of ASD individuals filled out an online survey consisting of 40 questions investigating socio-demographic and clinical characteristics of their children, impact of the COVID-19 outbreak on their wellbeing and needs to deal with the emergency. | 2020-06-08 |
| 32503180 | We evaluated the clinical features and prognosis of COVID-19 patients with AKI according to the AKI severity. | 2020-06-08 |
| 32503298 | In addition, presenting a virtual assistant can also measure the infection severity and connects with registered doctors when symptoms become serious. | 2020-06-08 |
| 32503333 | In this work, we conduct a proposed approach that is non-medical/clinical, generate graphs from five features of the SARS outbreak data in five countries and regions, and offer insights from a visual analysis perspective. | 2020-06-22 |
| 32503382 | The complexity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is centered on the unpredictable clinical course of the disease that can rapidly develop, causing severe and deadly complications. | 2020-06-12 |
| 32503620 | It helps break the cycle of inflammation through diverse mechanisms including reducing Intereukin-6, Interleukin-8, Tumour Necrosis Factor-alpha besides controlling oxidative stress pathways which all are important and pathologic components in the clinical course and outcome of patients infected with COVID-19. […] Primary: Time for clinical improvement and lung CT score changes 14 days after treatment. | 2020-06-08 |
| 32503657 | We will enroll patients who are discharged after treatment, whose nucleic acid test has changed from negative to positive during the screening visit, regardless of the severity of the symptoms, to investigate the mechanism, clinical outcome and therapeutic efficacy with Favipiravir patients with Corona virus Disease 2019. […] Regardless of whether or not they had symptoms and the severity of symptoms.4. […] Participating in other clinical studies. […] Loss to Follow up: Cases that do not complete the clinical trial program will be regarded as lost to follow up. […] Participants will be recruited from these 15 hospitals: Wuhan Pulmonary Hospital, Hubei; Jinyintan Hospital of Wuhan, Hubei; Ezhou Central Hospital, Hubei; The Second People’s Hospital of Fuyang, Anhui; The First Affiliated Hospital of USTC, Anhui; Beijing Youan Hospital, Beijing; Capital Medical University Beijing Institute of Hepatology, Beijing; Ezhou Hospital of Traditional Chinese Medicine, Hubei; Zhongnan Hospital of Wuhan University, Hubei; The Fifth Hospital of ShiJiazhuang, Hebei; Jinan Infectious Diseases Hospital, Shandong; Public Health Clinical Center of Chengdu, Sichuan; Wuxi No.5 People’s Hospital, Jiangsu; The Third People’s Hospital of Shenzhen, Guangdong; The First Affiliated Hospital of Bengfu Medical College, AnHui. […] Clinical cure [Time Frame: 5 months]: 1. […] Clinical manifestation improved;4. | 2020-06-08 |
| 32503662 | Furthermore, we hypothesize that early treatment with hydroxychloroquine sulphate is associated with more rapid resolve of clinical symptoms as assessed by the National Early Warning Score 2 (NEWS2), decreased admission rate to intensive care units and mortality, and improvement in protein biomarker profiles (C-reactive protein, markers of renal and hepatic injury, and established cardiac biomarkers like cardiac troponin and B-type natriuretic peptide). […] The study is a two-arm, open label, pragmatic randomised controlled group sequential adaptive trial designed to assess the effect on viral loads and clinical outcome of hydroxychloroquine sulphate therapy in addition to standard care compared to standard care alone in patients with established Covid-19. […] By utilizing resources already paid for by the hospitals (physicians and nurses in daily clinical practice), this pragmatic trial can include a larger number of patients over a short period of time and at a lower cost than studies utilizing traditional randomized controlled trial designs with an external study organization. […] All of the following conditions must apply to the prospective patient at screening prior to inclusion: (1) Hospitalisation; (2) Adults 18 years or older; (3) Moderately severe Covid-19 disease (NEWS2 of 6 or less); (4) SARS-CoV-2 positive nasopharyngeal swab; (5) Expected time of hospitalisation > 48 hours; and (6) Signed informed consent must be obtained and documented according to Good Clinical Practice guidelines of the International Conference on Harmonization, and national/local regulations. […] Clinical data, including standard hospital biochemistry, medical therapy, vital signs, NEWS2, and microbiology results (including blood culture results and reverse transcriptase polymerase chain reaction [RT-PCR] for other upper airway viruses), will be automatically extracted from the hospital electronic records and merged with the study specific database. […] Secondary endpoints include change in NEWS2 at 96 hours after randomisation, admission to intensive care unit, mortality (in-hospital, and at 30 and 90 days), duration of hospital admission, clinical status on a 7-point ordinal scale 14 days after randomization ([1] Death [2] Hospitalised, on invasive mechanical ventilation or extracorporeal membrane oxygenation [3] Hospitalised, on non-invasive ventilation or high flow oxygen devices [4] Hospitalized, requiring supplemental oxygen [5] Hospitalised, not requiring supplemental oxygen [6] Not hospitalized, but unable to resume normal activities [7] Not hospitalised, with resumption of normal activities), and improvement in protein biomarker profiles (C-reactive protein, markers of renal and hepatic injury, and established cardiac biomarkers like cardiac troponin and B-type natriuretic peptide) at 96 hours after randomization. | 2020-06-08 |
| 32503663 | The trial was registered on Clinical Trials.gov on March 30th, 2020 (ClinicalTrials.gov Identifier: NCT04326920) - retrospectively registered; https://clinicaltrials.gov/ct2/show/NCT04326920? | 2020-06-08 |
| 32503707 | The grave clinical context of the coronavirus disease 2019 (COVID-19) pandemic must be understood. | 2020-06-22 |
| 32503806 | During this pandemic clinical trial accrual to NCI studies has fallen dramatically. […] These changes will accelerate clinical progress while protecting our patients. | 2020-06-06 |
| 32503812 | We collected clinical and survival information of 2041 consecutive hospitalized patients with COVID-19 from two medical centers in Wuhan. | 2020-06-19 |
| 32503817 | Unfortunately, the antiviral drugs commonly used in clinical practice to treat viral infections, are not applicable to SARS-Cov-2 and no vaccine is available. […] Different preclinical studies conducted on other coronaviruses suggested that promising clinical outcomes for 2019-nCoV should be obtained by using alpha-interferon, chloroquine phosphate, arabinol, remdesivir, lopinavir/ritonavir, and anti-inflammatory drugs. […] Moreover, clinical trials with these suitable drugs should be performed on patients affected by SARS-Cov-2 to prove their efficacy and safety. | 2020-06-22 |
| 32503818 | Shortage of personal protective equipment, suspension of clinical clerkships and observerships and reduction in elective surgical cases unavoidably affect medical and surgical education. […] Furthermore, trainee’s mental health should be safeguarded, and medical students can be involved in the COVID-19 clinical treatment if needed. | 2020-06-22 |
| 32503819 | The most ubiquitous topic was COVID-19 clinical features. | 2020-06-22 |
| 32503820 | Nevertheless, the vast majority of cases present mild symptoms or none. | 2020-06-22 |
| 32503824 | A total of 9 patients (4 patients diagnosed with pneumonia and 5 patients diagnosed with SARS-COV-2 infection) who admitted to the emergency Department with symptoms of pneumonia and SARS-COV-2 were included in the study. | 2020-06-22 |
| 32503825 | Patient characteristics including age, marital status, SBL/BC diameter, personal and family history of BC, clinical stage and molecular subtype were recorded. | 2020-06-22 |
| 32503826 | The aim of this study was to evaluate measures that could potentially reduce the clinical impact of COVID-19 on BC patients. | 2020-06-22 |
| 32503829 | Clinical and radiographic data were obtained from the electronic medical record. | 2020-06-22 |
| 32503830 | Despite the large amount of clinical data available of Coronavirus-19 (COVID-19), not many studies have been conducted about the psychological toll on Health Care Workers (HCWs). | 2020-06-22 |
| 32503874 | The primary endpoint will be time to clinical recovery. […] The secondary endpoints will be proportion of participants relieved from clinical symptoms defined at the time (in hours) from initiation of the study treatment, all-cause mortality, discharged date, frequency of respiratory progression and treatment-emergent adverse events. | 2020-06-16 |
| 32503877 | These results suggest that targeting excessive host inflammation with a BTK inhibitor is a therapeutic strategy in severe COVID-19 and has led to a confirmatory international prospective randomized controlled clinical trial. | 2020-06-19 |
| 32504052 | Detection of asymptomatic or subclinical novel human coronavirus SARS-CoV-2 infection is critical for understanding the overall prevalence and infection potential of COVID-19. | 2020-06-06 |
| 32504100 | We sought to describe the ocular manifestations of COVID-19 and investigate the association between ocular involvement and clinical presentation and laboratory outcomes. […] The systemic and ocular symptoms, clinical findings, and laboratory outcomes were recorded. | 2020-06-09 |
| 32504106 | For this purpose, demographic data, laboratory parameters, and clinical outcomes were recorded and evaluated. | 2020-06-09 |
| 32504146 | On March 11, 2020, the new clinical condition COVID-19 (Corona-Virus-Disease-19) was declared a pandemic by the World Health Organization (WHO). […] This case emphasizes the possibility of a rapid severe disease onset in previously mild clinical condition and highlights the necessity of a complete autopsy to gain a better understanding of the pathophysiological changes in SARS-CoV-2 infections. | 2020-06-20 |
| 32504360 | The clinical characteristics and outcome of COVID-19 in children are different from those in adults. […] Clinical features, chest imaging findings, laboratory tests results, treatments and clinical outcomes were analyzed. […] Cough (77.78%) and fever (47.22%) were the most common clinical manifestations. […] Most infants with COVID-19 have mild clinical symptoms and good prognosis. | 2020-06-25 |
| 32504363 | Recognizing that the strength of any clinical training program is its wealth of patients, the immediate resumption of patient services, albeit limited at first, had been instrumental in ensuring the continuation of training in our institution. | 2020-06-09 |
| 32504532 | We describe the clinical course of 57 children with coronavirus disease 2019 (COVID-19) cared for through a single hospital system. | 2020-06-26 |
| 32504552 | Clinical appointments and pharmacy antiretroviral refills may be impaired due to restricted traffic and possible lockdowns, preventing people living with HIV and those using PrEP from accessing needed antiretrovirals. | 2020-06-14 |
| 32504637 | Finally twenty-three patients hospitalized in high-intensity care unit showed an MDW value higher than the eighteen patients presenting few symptoms [28.8 ± 5.3 vs 25.4 ± 3.6 respectively, P < 0.05]. | 2020-06-27 |
| 32504735 | Both the ELISA and POC tests were able to detect SARS-CoV-2 antibodies in at least half of the samples collected seven days or more after the onset of symptoms. […] Seroconversion was observed 5 to 12 days after the onset of symptoms. | 2020-06-19 |
| 32504743 | Two point-prevalence surveys were performed one week apart where residents underwent SARS-CoV-2 testing and had relevant symptoms documented. […] Systematic testing identified 40% (95% CI 35-46) of residents as positive for SARS-CoV-2, and of these 43% (95% CI 34-52) were asymptomatic and 18% (95% CI 11-24) had only atypical symptoms; 4% (95% CI -1 to 9) of asymptomatic staff also tested positive. […] Many residents developed either atypical or had no discernible symptoms. | 2020-06-13 |
| 32504745 | Our study revealed that the serological testing is useful for the identification of asymptomatic or subclinical infection of SARS-CoV-2 among close contacts with COVID-19 patients. | 2020-06-12 |
| 32504808 | Duration of loneliness was more strongly correlated with mental health symptoms than intensity of loneliness. […] Clinical services should offer preventative support and early intervention where possible and be prepared for an increase in mental health problems. | 2020-06-09 |
| 32504923 | In vivo, in vitro, and human clinical trials have demonstrated N-acetylcysteine (NAC) as an effective method of improving redox status, especially when under oxidative stress. […] In human clinical trials, NAC has been used to replenish glutathione stores and increase the proliferative response of T cells. […] NAC has also been shown to inhibit the NLRP3 inflammasome pathway (IL1β and IL18) in vitro, and decrease plasma TNF-ɑ in human clinical trials. | 2020-06-16 |
| 32504925 | In this opinion article, we conjecture a dialogue by the figure of Sérgio Ferreira which brought together basic science of classical pharmacology and clinical repercussions in COVID-19, then we propose that in the course of SARS-CoV-2 infection: i) downregulation of ACE2 impairs the angiotensin II and DABK inactivation; ii) BK and its metabolite DABK seems to be in elevated levels in tissues by interferences in kallikrein/kinin system; iii) BK1 receptor contributes to the outbreak and maintenance of the inflammatory response; iv) kallikrein/kinin system crosstalks to RAS and coagulation system, linking inflammation to thrombosis and organ injury. | 2020-06-16 |
| 32504927 | Periodontal pockets are the major clinical manifestation of Periodontitis, a chronic inflammatory oral disease affecting the teeth-supporting tissues and has high prevalence in the adult population. | 2020-06-16 |
| 32504945 | SARS-CoV-2 infection diagnosis is challenging in patients from 2 to 3 weeks after the onset of symptoms, due to the low positivity rate of the PCR. […] Then, we prospectively evaluated the test in 61 patients with clinical diagnosis of pneumonia of unknown etiology that were negative for SARS-CoV-2 by PCR (group 3). […] For these 90 group-2 patients, the test was positive for either IgM or IgG in 58 (overall sensitivity = 64.4 %), and in patients tested 14 days or more after the onset of symptoms, the sensitivity was 88.0 %. […] Our study shows that Alltest lateral flow immunoassay is reliable as a complement of PCR to diagnose SARS-CoV-2 infection after 14 days from the onset of symptoms and in patients with pneumonia and negative PCR for SARS-CoV-2. | 2020-06-26 |
| 32504946 | To evaluate analytical and clinical performance of the RealTime SARS-CoV-2 assay compared to the SARS-CoV-2 CDC-based laboratory developed test (LDT) in clinical use by the University of Washington Clinical Virology Laboratory (UW Virology). […] Cross-reactivity was evaluated by testing 24 clinical samples positive for various non‒SARS-CoV-2 respiratory viruses. […] Clinical performance was evaluated using 30 positive and 30 negative SARS-CoV-2 clinical samples previously tested using the UW Virology SARS-CoV-2 LDT. […] All clinical samples positive for 24 non‒SARS-CoV-2 respiratory viruses were SARS-CoV-2 negative on the RealTime SARS-CoV-2 assay. […] The assay had high sensitivity (93%) and specificity (100%) for detecting SARS-CoV-2 in clinical samples. […] The RealTime SARS-CoV-2 assay is acceptable for clinical use. | 2020-06-26 |
| 32505070 | Lidocaine, a local analgesic and anti-arrhythmic, is known for its anti-inflammatory actions and has been used to reduce cough and improve respiratory symptoms in severe asthmatic patients. […] It is proposed that nebulized lidocaine might be beneficial in reducing cytokines, protecting patients’ lungs and improving outcomes in COVID-19 patients when administered via inhalation as an adjunctive treatment for severe respiratory symptoms in patients fighting the novel Coronavirus. | 2020-06-28 |
| 32505076 | We also describe clinical and demographic factors associated with poor prognosis and Covid-19 treatment outcomes. […] We retrospectively reviewed 1878 medical records of all Covid-19 patients who were admitted at Hospital Universitario Infanta Leonor of Madrid between March 5, 2020 and April 7, 2020, in order to detect cumulative incidence of Covid-19 in lung cancer patients. […] We also described Covid-19 treatment outcome, mortality and associated risk factors using univariate and multivariate logistic regression analysis. 17/1878 total diagnosis in our center had lung cancer (0.9 %) versus 1878/320,000 of the total reference population (p = 0.09). 9/17 lung cancer patients with Covid-19 diagnosis died (52.3 %) versus 192/1878 Covid-19 patients in our center (p < 0.0001). | 2020-06-26 |
| 32505172 | The best way to better understand bias in the epidemic curves of COVID-19 due to errors in testing is to empirically evaluate misclassification of diagnosis in clinical settings and apply this knowledge to adjustment of epidemic curves. | 2020-06-22 |
| 32505227 | We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection. | 2020-06-25 |
| 32505251 | System challenges include: the suboptimal education and training of primary health-care practitioners, a fee-for-service payment system that incentivises testing and treatments over prevention, fragmentation of clinical care and public health service, and insufficient continuity of care throughout the entire health-care system. […] The following recommendations merit consideration: (1) enhancement of the quality of training for primary health-care physicians, (2) establishment of performance accountability to incentivise high-quality and high-value care; (3) integration of clinical care with the basic public health services, and (4) strengthening of the coordination between primary health-care institutions and hospitals. | 2020-06-10 |
| 32505456 | Systematic appraisal of senior surgeons’ consensus can be used to generate interim recommendations until data from clinical observations become available. […] Hence, we aimed to collect and quantitatively appraise nationwide UK consultants’ opinions on clinical decision making for patients requiring cardiac surgery during the COVID-19 pandemic. […] In this unprecedented pandemic period, this survey provides information for generating interim recommendations until data from clinical observations become available. | 2020-06-11 |
| 32505462 | In this study, we aimed to report the epidemiological and clinical characteristics of a familial cluster infection including children with SARS-CoV-2. […] Both case 1 and case 2 got mild symptoms. […] Case 3 did not develop any symptoms until February 6, 2020, with an asymptomatic period of 15 days. […] Her nucleic acid test turned positive until Feb 21, 2020, 15 days after symptoms onset, 30 days after her return from Wuhan. | 2020-06-17 |
| 32505489 | The symptomatic evolution of patients with COVID-19 is characterized by 2 phases: an acute phase in which respiratory symptoms prevail and a postacute phase in which patients can show symptoms related to prolonged immobilization, to previous and current respiratory dysfunctions, and to cognitive and emotional disorders. […] This communication reports the experience of the San Raffaele Hospital of Milan and recommends the setup of specialized clinical pathways for the rehabilitation of patients with COVID-19. […] In this hospital, between February 1 and March 2, 2020, about 50 patients were admitted every day with COVID-19 symptoms. […] Such clinical pathways should each involve dedicated multidisciplinary teams composed of pulmonologists, physiatrists, neurologists, cardiologists, physiotherapists, neuropsychologists, occupational therapists, speech therapists, and nutritionists. | 2020-06-23 |
| 32505492 | We discuss how the classical ethical principles of utility, justice, and efficiency may need to be adapted, and we give specific recommendations for thoracic transplantation and mechanical circulatory support centers to balance their clinical decisions and strategies for advanced heart and lung disease during the current pandemic. | 2020-06-11 |
| 32505599 | We aimed to assess the prevalence of significant computed tomographic(CT) manifestations and describe some notable features based on chest CT images, as well as the main clinical features of patients with coronavirus disease 2019(COVID-19). […] A systematic literature search of PubMed, EMBASE, the Cochrane Library, and Web of Science was performed to identify studies assessing CT features, clinical, and laboratory results of COVID-19 patients. […] In terms of clinical features, muscle soreness (21%, 95% CI 15-26%) and diarrhea (7%, 4-10%) were minor symptoms compared to fever (80%, 74-87%) and cough (53%, 33-72%). […] Chest CT manifestations in patients with COVID-19, as well as its main clinical characteristics, might be helpful in disease evolution and management. | 2020-06-25 |
| 32505643 | Over 80% of respondent families participants reported that they agreed or strongly agreed that they were able to ask all of their questions, felt comfortable expressing their thoughts and feelings with the clinical team, felt like they understood the care their loved one received, and that the virtual family meeting helped them trust the clinical team. | 2020-06-11 |
| 32505730 | The typical clinical manifestations were fever, cough, dyspnea, and myalgia or fatigue. […] Digestive symptoms such as nausea, vomiting, diarrhea, abdominal pain usually accompany respiratory symptoms. […] The case demonstrate that; clinicians should be alerted to patients about COVID-19 when referring to atypical symptoms and every patient undergoing endoscopy should be considered potentially infected or can infect others. | 2020-06-11 |
| 32505774 | In the ongoing COVID-19 pandemic, there is an urgent need for comprehensive performance evaluation and clinical utility assessment of serological assays to understand the immune response to SARS-CoV-2. […] Clinical utility was evaluated by both methods in 87 patients at initial emergency department visit, 28 during subsequent hospitalizations (106 serial samples), and 145 convalescent patients. […] Rigorously validated CEFA and MIA assays are reliable for detecting antibodies to SARS-CoV-2 and show promising clinical utility when evaluating immune response in hospitalized and convalescent patients, but are not useful for early screening at patient’s initial ED visit. | 2020-06-27 |
| 32505777 | So far, there is limited data on how recently commercially available, high-throughput immunoassays, using different recombinant SARS-CoV-2 antigens, perform with clinical samples. | 2020-06-26 |
| 32505778 | A test-based strategy that requires negative respiratory RT-PCR tests obtained after the resolution of symptoms. | 2020-06-26 |
| 32505846 | Recently, the safety of ibuprofen in COVID-19 patients has been questioned due to anecdotal reports of worsening symptoms in previously healthy young adults. | 2020-06-26 |
| 32505908 | A multiple sclerosis patient infected by SARS-CoV-2 during fingolimod therapy was hospitalized with moderate clinical features, and recovered in 15 days. | 2020-06-26 |
| 32505910 | Most COVID-19 infected individuals present with mild flu-like symptoms; however, 5-10% of cases suffer from life-threatening pneumonia and respiratory failure. | 2020-06-16 |
| 32505992 | Pre and post self-evaluations were measured using standardized clinical competency questionnaires on a 5-point Likert Scale ranging from “No knowledge, unable to perform” up to “Highly knowledgeable and confident, independent.” Physicians self-reported a significant increase in knowledge and competency immediately after completing the training exercise. | 2020-06-25 |
| 32506055 | Epidemiological, clinical feature, and detailed data on all cases were recorded. […] Practical workflow for the clinical management of dialysis patients, caregivers, and HCP was initiated. […] Potential risk factors and underlying clinical patterns were reported. | 2020-06-07 |
| 32506110 | The outcomes were mortality, recovery rate, length of hospital stay and clinical outcome. […] The safety and efficacy of this drug in COVID-19 cases require high-quality evidence from well-designed and adequately-powered clinical trials with proper sample size for precise decision. | 2020-06-09 |
| 32506111 | This document prepared for our nation by the Bangladesh Society of Cardiovascular Interventions (BSCI) is intended to serve as a clinical practice guideline for cardiovascular health care professionals, with a focus on modifying standard practice of care during the COVID-19 pandemic, in order to ensure continuation of adequate and timely treatment of cardiovascular emergencies avoiding hospital-based transmission of SARS-COV-2 among healthcare professionals and the patients. […] This guideline is limited to the provision of cardiovascular care, and it is expected that specific targeted pharmaco-therapeutics against SARS-CoV-2 be prescribed as stipulated by the National Guidelines on Clinical Management of Corona virus Disease 2019 (COVID-19) published by the Director General of Health Services, Ministry of Health and Family Welfare of Bangladesh. | 2020-06-09 |
| 32506118 | Using data for 20,912 patients from two large academic health systems, we analyzed the frequency of SARS-CoV-2 RT-PCR test-discordance among individuals initially testing negative by nasopharyngeal swab who were retested on clinical grounds within 7 days. | 2020-06-26 |
| 32506122 | aim of the present study is to describe characteristics of COVID-19 related deaths and to compare the clinical phenotype and course of COVID-19 related deaths occurring in adults (< 65 years) and older adults (≥ 65 years). medical charts of 3,032 patients dying with COVID-19 in Italy (368 aged < 65 years and 2,664 aged ≥ 65 years) were revised to extract information on demographics, pre-existing comorbidities, and in-hospital complications leading to death. | 2020-06-26 |
| 32506142 | Depending on clinical status (symptomatic or non-symptomatic), the information useful for the orthopaedist surgeon and obtained from the Chest CT scan according to the result of the PCR (gold standard) was graded from 0 (no or low value) to 3 (high value). | 2020-06-11 |
| 32506145 | One of the most important roles of otolaryngologists when encountering airway-related signs and symptoms in patients with previous ICU hospitalization for COVID-19 is to maintain a high level of suspicion for LTS development, and share it with colleagues and other health care professionals. | 2020-06-11 |
| 32506184 | These tools will be even more important post-COVID-19, as the landscape of clinical outpatient care changes from mainly in-person visits to a greater reliance on telemedicine and remote monitoring. | 2020-06-17 |
| 32506195 | The aforementioned observation underlined that mechanism of cell entry is supposedly similar among different coronavirus, that the co-expression of ACE2 and DPP4/CD26 could identify those cells targeted by different human coronaviruses and that clinical complications may be similar. | 2020-06-24 |
| 32506258 | Parts of the expert statement are based on epidemiological and clinical evidence, without available scientific evidences. | 2020-06-11 |
| 32506364 | We report a 66-year-old female patient with post-mortem diagnosis of COVID-19 who presented progressive livedo racemosa, acute renal failure and myocardial injury, as well as an absence of respiratory symptoms. | 2020-06-11 |
| 32506699 | Patients followed at two referral rheumatology centres in Lombardy from 25th February to 10th April 2020 were invited to participate in a survey to detect patients with confirmed COVID-19, close contacts with known COVID-19 cases, symptoms of infection, working, behavioural and disease management changes applied to prevent the contagion. | 2020-06-19 |
| 32506725 | While both virus-caused infections may only reveal light symptoms, they can also cause severe diseases. […] No clinical data exist indicating such mechanism for SARS-CoV-2, but previous coronavirus infections or infection of SARS-CoV-2 convalescent with different SARS-CoV-2 strains could promote ADE, as experimentally shown for antibodies against the MERS-CoV or SARS-CoV spike S protein. | 2020-06-19 |
| 32506726 | The clinical features of patients during their hospitalization and 2-week postdischarge quarantine were collected. […] The median time from symptoms onset to final respiratory SARS-CoV-2 detection of negative result was significantly longer in re-positive group (34 days [IQR, 29.5-42.5]) than in non-re-positive group (19 days [IQR, 16-26]). […] However, only one case in re-positive group showed exudative lesion recurrence in pulmonary computed tomography (CT) with recurred symptoms. | 2020-06-19 |
| 32506762 | As COVID-19 presents with severe symptoms and is associated with a high mortality rate in dialysis patients, dialysis patients who have contracted SARS-CoV-2 infection confirmed by polymerase chain reaction (PCR) testing are required to be hospitalized under Japanese government policy. | 2020-06-19 |
| 32506768 | Epidemiological, clinical, radiological features, additional diseases, laboratory tests, complications and outcome data of all patients were recorded. | 2020-06-23 |
| 32506865 | The present interpretation of the TCM protocol is based on an overall understanding of the revised content, and aims to guide and standardize its clinical application to provide a reference for clinicians. | 2020-06-22 |
| 32506866 | Secondary transmission occurred on the first day of illness of the infector, and his symptoms were suggestive of a common cold. | 2020-06-11 |
| 32506937 | The SARS-CoV-2 virus causes symptoms in infected individuals ranging from mild flu symptoms via severe COVID-19 pneumonia requiring ventilation to death. | 2020-06-08 |
| 32507112 | The National University Hospital (NUH) is Singapore’s third largest hospital with 1200 beds, heavy clinical workloads, and major roles in research and teaching. | 2020-06-11 |
| 32507114 | The correlation of viral load of patients’ clinical samples and environmental samples were analyzed. […] There was a significant correlation between viral load ranges in clinical samples and positivity rate of environmental samples (p < 0.001). | 2020-06-08 |
| 32507119 | Semi-structured interviews were conducted with 30 individuals attending the Galway-Roscommon Mental Health Services with an ICD-10 diagnosis of an anxiety disorder to determine the impact of the Covid-19 restrictions on anxiety and mood symptoms, social and occupational functioning and quality of life. […] Twelve (40.0%) participants described COVID-19 restrictions as having a deleterious impact on their anxiety symptoms. […] Likert scale measurements noted that the greatest impact of COVID-19 related to social functioning (Mean = 4.5, SD = 2.9), with a modest deleterious effect on anxiety symptoms noted (Mean = 3.8, SD = 2.9). […] Clinician rated data noted that 8 (26.7%) participants had disimproved and 14 (46.7%) participants had improved since their previous clinical review, prior to commencement of COVID-19 restrictions. […] Conditions associated with no ‘trigger’, such as generalised anxiety disorder, demonstrated a non-significant increase in anxiety symptoms compared to conditions with a ‘trigger’, such as obsessive compulsive disorder. | 2020-06-08 |
| 32507122 | Four types of clinical cases are presented here because they have led these EMS teams to change practices in their management of patients suspected of COVID-19 infection: cardiac arrest, hypoxia on an acute pneumonia, acute chronic obstructive pulmonary disease (COPD) exacerbation with respiratory and hemodynamic disorders, and upper function disorders in a patient in a long-term care facility. | 2020-06-19 |
| 32507123 | To slow down the transmission of coronavirus disease 2019 (COVID-19), it is important to identify specific symptoms for effective screening. […] While anosmia/hyposmia and dysgeusia/ageusia have been identified as highly prevalent symptoms, there are wide geographic variations, necessitating the regional evaluation of the prevalence of the symptoms. […] A cross-sectional study was performed to evaluate the self-reported symptoms among adults (over 18 years old) who underwent COVID-19 tests at an ambulatory assessment centre. […] In this Canadian study, smell and taste loss may be key symptoms of COVID-19. […] This evidence can be helpful in the clinical diagnosis of COVID-19, particularly settings of limited testing capacity. | 2020-06-25 |
| 32507409 | There has been an unprecedented rapid response by vaccine developers with now over one hundred vaccine candidates in development and at least six having reached clinical trials. […] To address this challenge, the Coalition for Epidemic Preparedness Innovations (CEPI) and the Brighton Collaboration (BC) Safety Platform for Emergency vACcines (SPEAC) convened a scientific working meeting on March 12 and 13, 2020 of experts in the field of vaccine immunology and coronaviruses to consider what vaccine designs could reduce safety concerns and how animal models and immunological assessments in early clinical trials can help to assess the risk. | 2020-06-22 |
| 32507410 | All of this partly explains the contagiousness and the clinical expression of these two viruses from the olfactory cleft to the alveoli. | 2020-06-11 |
| 32507556 | Yet, risk of onset or aggravation of panic disorder, especially the subtype with prominent respiratory symptoms, which is characterized by a fear response conditioning to interoceptive sensations (e.g., respiratory), and hypervigilance to these interoceptive signals, could be expected in the current situation. […] Indeed, respiratory symptoms, such as coughs and dyspnea, are among the most commonly associated with the SARS-CoV-2 (59-82% and 31-55%, respectively), and respiratory symptoms are associated with a poor illness prognosis. | 2020-06-11 |
| 32507619 | SARS-CoV-2 disease (COVID-19) is a major challenge for the healthcare system and physicians, imposing changes in daily clinical activity. we aimed to describe what European trainees and young gastroenterologists know about COVID-19 and identify training gaps to implement educational programs. […] COVID-19 outbreak significantly impacted on gastroenterologists’ clinical activity. | 2020-06-11 |
| 32507686 | Advances in treating and preventing Alzheimer disease and other neurocognitive disorders of aging arise from rigorous preclinical and clinical research, with randomized controlled treatment trials as the last and definitive test. | 2020-06-11 |
| 32507692 | To explore the clinical characteristics of Coronavirus Disease (COVID-19) patients with gastrointestinal symptoms. […] The clinical data of 164 COVID-19 patients with gastrointestinal symptoms were extracted and analysed retrospectively. […] In total, 505 COVID-19 patients were divided into two groups: those with gastrointestinal symptoms (G group) and those without gastrointestinal symptoms (NG group). […] Common gastrointestinal symptoms included inappetence, diarrhoea, nausea, abdominal pain, and vomiting. […] In Wuhan, the proportion of COVID-19 patients who experience gastrointestinal symptoms is relatively high. […] Patients who experience gastrointestinal symptoms are more likely to suffer from severe pneumonia, which may help clinicians identify patients at high risk of COVID-19 and thus reduce the incidence of this condition. | 2020-06-11 |
| 32507746 | Since COVID-19 symptoms are aspecific and may resemble a common cold, if it should come back with a seasonal pattern and coincide with the influenza season, this would be particularly challenging, overwhelming and straining the healthcare systems, particularly in resource-limited contexts, and would increase the likelihood of nosocomial transmission. […] In the present study, we devised a mathematical model focusing on the treatment of people complaining of influenza-like-illness (ILI) symptoms, potentially at risk of contracting COVID-19 or other emerging/re-emerging respiratory infectious agents during their admission at the health-care setting, who will occupy the detection kits causing a severe shortage of testing resources. | 2020-06-25 |
| 32507849 | Using snowball sampling approach, 1,596 people residing in Spain during the lockdown answered an online questionnaire that included information on sociodemographic variables, symptoms, and contact with the disease, risk perception, precautionary measures to prevent infection and coping strategies during lockdown. | 2020-06-09 |
| 32507883 | After transmembrane angiotensin-converting enzyme 2 (ACE2) has been found to be SARS-CoV-2 receptor, we hypothesized an immune-hematological mechanism for Covid-19 based on renin-angiotensin system (RAS) imbalance to explain clinical, laboratory and imaging findings on disease course. | 2020-06-16 |
| 32507963 | However, such general guidance does not provide information regarding COVID-19 risks in patients with suffering from pre-existing thyroid problems, and furthermore, we do not know whether patients with COVID-19 (symptomatic or without symptoms), who have not previously had thyroid issues develop endocrine thyroid dysfunction after infection. | 2020-06-25 |
| 32508022 | According to the clinical data of infected patients, radiologic evidence of lung edema is common and deserves clinical attention. […] In this article, we focus on the lung edema and ALI of patients with this widely transmitted COVID-19 infection in order to provide clinical indications and potential therapeutic targets for clinicians and researchers. | 2020-06-11 |
| 32508026 | Furthermore, reverse transcription-polymerase chain reaction (RT-PCR) assay, colloidal gold immunochromatography assay, serological validation of cross reaction with other common viruses, and clinical validation were performed. […] Therefore, the rapid detection kit has high sensitivity and specificity, especially for IgM&IgG, showing a critical value in clinical application and epidemic control of COVID-19. | 2020-06-08 |
| 32508038 | The clinical presentation of SARS-CoV-2-infected pneumonia (COVID-19) resembles that of other etiologies of community-acquired pneumonia (CAP). […] We aimed to identify clinical laboratory features to distinguish COVID-19 from CAP. | 2020-06-11 |
| 32508041 | Clinical phenomes of patients with SARS-CoV-2 infection are critical in distinguishing it from other respiratory infections. […] We summarized clinical phenomes of 3795 patients with COVID-19 based on 80 published reports from the onset of outbreak to March 2020 to emphasize the importance and specificity of those phenomes in diagnosis and treatment of infection, and evaluate the impact on medical services. […] Clinical phenomes of SARS-CoV-2 infection were compared with those of SARS-CoV and MERS-CoV infections. | 2020-06-11 |
| 32508168 | We aimed to provide a literature review on the putative effectiveness and safety of available treatments for COVID-19 in pregnant women.Methods: We reviewed all the available literature concerning the drugs that have been used in the treatment of COVID-19 during pregnancy and whose safe assumption during pregnancy had been demonstrated by clinical studies (i.e. including studies on other infectious diseases). […] Drugs contra-indicated during pregnancy or with unknown adverse effects were not included in our review.Results and conclusions: Clinical trials are not often conducted among pregnant patients for safety reasons and this means that drugs that may be effective in general population cannot be used for pregnant women due to the lack of knowledge of side effects in this category of people . | 2020-06-12 |
| 32508257 | During the pandemic, despite regulatory agencies’ recommendations, several considerations and doubts remain for oncologic clinical trials. | 2020-06-08 |
| 32508311 | In this review, we highlight the growing evidence in support of androgen regulation of TMPRSS2 and ACE2 and the potential clinical implications of using androgen suppression to downregulate TMPRSS2 to target SARS-CoV-2. | 2020-06-08 |
| 32508313 | Due to the restrictions imposed by the pandemic, people with diabetes may suffer longer-term harm caused by inadequate clinical support and less frequent monitoring of their condition and diabetes-related complications. […] Resulting challenges in clinical decision making are compounded by a reduced clinical workforce. […] While the current focus is on limiting the terrible harm caused by the pandemic, it is possible that a positive lasting legacy of COVID-19 might include accelerated innovation in chronic disease management. | 2020-06-09 |
| 32508388 | Specific recommendations must be followed concerning the type of training, its intensity, the precautions that have to be followed to avoid the possibility of contagion, and the restrictions in accordance with the presence of any symptoms. | 2020-06-09 |
| 32509006 | The stress surrounding this biothreat appears to have clinical implications in all aspects of medicine, both in mental and physical health spheres. | 2020-06-09 |
| 32509205 | So far, there have been mounting research on the epidemiological and clinical characteristics of COVID-19. […] The current study reviewed published evidence of clinical interventions of severe and critical COVID-19, aiming to provide an up-to-date reference for further clinical treatment. | 2020-06-11 |
| 32509258 | A few clinical syndromes may follow, such as pulmonary edema based on arterial vasoconstriction and altered alveolo-capillary barrier, sideroblastic-like anemia, endotheliitis, vasospastic acrosyndrome, and arterio- venous thromboembolism. | 2020-06-09 |
| 32509310 | Our clinical data from patients suggest that clinical symptoms differ between European countries. […] We therefore suggest combining clinical information from patients and the determination of the associated SARS-CoV-2 genome to better understand the specific symptoms. | 2020-06-09 |
| 32509416 | After presenting with mild symptoms, both quickly developed worsening respiratory distress requiring intubation, and both delivered preterm via caesarean delivery. | 2020-06-09 |
| 32509860 | The clinical decision-making process and the organizational workflow of radiotherapy department should be revised in the light of the critical situation. | 2020-06-11 |
| 32509977 | In combination with medical therapies, or as an alternative, we encourage patients to consider self-management strategies to combat endometriosis symptoms during the COVID-19 pandemic. | 2020-06-09 |
| 32510102 | There was also consensus on testing residents with atypical symptoms in a scenario of limited testing capability. […] The panel favored testing every 1 to 2 weeks if testing was readily available, reducing the frequency to every month as community prevalence declined or as the collection of additional data further informed clinical critical thinking and decision-making. | 2020-06-11 |
| 32510106 | We assessed the prevalence, clinical presentation and outcomes of dementia among subjects hospitalized for COVID19 infection. […] Clinical records of each patients admitted to the hospital with a diagnosis of COVID19 infection were retrospectively analyzed. […] Diagnosis of dementia, modalities of onset of the COVID-19 infection, symptoms of presentation at the hospital and outcomes were recorded. […] Among patients diagnosed with dementia the most frequent symptoms of onset were delirium, especially in the hypoactive form, and worsening of the functional status. […] The clinical presentation of COVID-19 in subjects with dementia is atypical, reducing early recognition of symptoms and hospitalization. | 2020-06-11 |
| 32510142 | The immediacy of this problem suggests that drug strategies should focus on repurposing approved drugs or late-stage clinical candidates, as these have the shortest path to use in the clinic. | 2020-06-08 |
| 32510164 | The clinical data of all suspected patients were analyzed. | 2020-06-19 |
| 32510168 | Most of the SARS-CoV-2 samples were from individuals with moderate to the severe clinical course, who required an in-patient hospital stay. | 2020-06-24 |
| 32510169 | This study aims to explore the clinical effect of Arbidol (ARB) combined with adjuvant therapy on patients with coronavirus disease 2019 (COVID-19). | 2020-06-19 |
| 32510173 | Coronavirus disease 2019 (COVID-19) is a health emergency worldwide, and gastrointestinal (GI) symptoms are increasingly reported in COVID-19 patients. […] However, sample size was small and the incidence of GI symptoms in patients was variable across studies, and the correlation between these symptoms and clinical outcomes remains incompletely understood. […] The objective of this study is to compare clinical characteristics and outcomes between patients with and without GI symptoms admitted to Jianghan Fangcang Shelter Hospital in Wuhan. […] Data on epidemiological and clinical characteristics, laboratory findings, treatment procedures, and clinical outcomes were retrieved from electronic medical records. […] On the basis of the presence of GI symptoms, the sample was divided into a GI group (n=192) and a non-GI group (n=1128). […] The most common GI symptoms were diarrhea (8.1%), anorexia (4.7%), and nausea and vomiting (4.3%). […] The risk of clinical deterioration was significantly higher in the GI group than in the non-GI group (15.6% vs. […] GI symptoms (p=0.045), male gender (p<0.001), and increased C-reactive protein (p=0.008) were independent risk factors for clinical worsening. […] The risk of clinical deterioration was significantly higher in the GI group. […] Furthermore, potential risk factors for developing GI symptoms, male gender, and increased C-reactive protein can help clinicians predict clinical outcomes in COVID-19 patients. | 2020-06-19 |
| 32510340 | It is concluded that the detection methods targeting antibodies are not suitable for screening of early and asymptomatic cases since most patients had an antibody response at about 10 days after onset of symptoms. | 2020-06-23 |
| 32510576 | Participants were well informed about the symptoms, diagnosis, modes of transmission, and methods of prevention. | 2020-06-26 |
| 32510581 | To evaluate the clinical characteristics and laboratory test results in pregnant women with coronavirus disease 2019 (COVID-19). […] A retrospective study to review and compare clinical data including electronic medical records and laboratory tests from pregnant and nonpregnant patients admitted the Central Hospital of Wuhan, China from December 8, 2019 to April 1, 2020. […] Compared with the nonpregnant group, pregnant patients were admitted to hospital earlier (0.25 vs 11.00 days; P<0.001), presented milder symptoms, had a higher rate of asymptomatic infection (26.7% vs 0%), and shorter length of hospital stay (14.5 vs 17.0 days; P<0.01). […] In some respects, the clinical characteristics and laboratory test results of COVID-19 in pregnant patients seems to be distinctive from their nonpregnant counterparts. […] Pregnant patients with COVID-19 had their own positive clinical characteristics and special laboratory test results. | 2020-06-08 |
| 32510734 | However, as a result of positive clinical experience with azithromycin used alone during the first few days of the flu-like illness caused by this coronavirus, we recommend formal clinical trials using azithromycin early in the course of a COVID-19 infection. […] There is one clinical trial initiated, the individually-randomized, telemedicine-based, “Azithromycin for COVID-19 Treatment in Outpatients Nationwide (ACTION)” based at the University of California San Francisco. […] We recommend formal clinical trials of azithromycin in its prepackaged form at the first sign of COVID-19 infection in adults and children, using an initial adult dose of 500 mg followed by 250 mg per day for four days, a total cumulative dose of 1.5 g, and for children 5 to 18 years of age, 10 mg/kg on the first day followed by 5 mg/kg for four days. | 2020-06-19 |
| 32510756 | There is fast-emerging, cumulative clinical data on coronavirus disease 2019 (COVID-19) in kidney transplant recipients. […] Although respiratory tract symptoms are often the initial presentation among kidney transplant recipients who contract COVID-19, other clinical features which may indicate underlying SARS-CoV-2-related inflammation, such as gastrointestinal symptoms, are not uncommon. […] However, the clinical course and prognostic value of hyponatremia in this population is not described in detail. […] Hyponatremia is one of the clinical presentations of COVID-19, although less common, and may occur more frequently in kidney transplant recipients. | 2020-06-08 |
| 32510771 | Clinical course seemed favorable in three of our patients, but one of them deteriorated after 10 days of hospitalization, probably due to an acute form of graft dysfunction triggered both by COVID-19 and a nosocomial bacterial infection, and eventually died. […] Although short-term prognosis could be considered benign in the majority of our patients, we should carefully monitor these individuals in order to detect early sign of clinical deterioration and graft dysfunction in the next few months. | 2020-06-26 |
| 32510821 | (Sun, Qie, Liu, Ren, & Xi, 2020) Preliminary studies have shown that hospitalized patients have different symptoms, including myalgia, whooping cough, fatigue, and dyspnea and gastrointestinal complains. | 2020-06-08 |
| 32510901 | We will further describe its mechanism of action, diagnosis, symptoms, and potential effects on the male reproductive system. | 2020-06-08 |
| 32511033 | Early emergent global data reveal that severity of clinical outcome from COVID-19 infection (including hospitalization and admission to Intensive Care Unit [ICU]), associate with co-morbidities, prominently DM. […] Like a phoenix from the ashes though, COVID-19 provides us with a great learning opportunity to renew insights into ourselves as individuals, our clinical teams, and the optimized provision of care for our patients. | 2020-06-08 |
| 32511042 | Severe restrictions have been imposed in most countries for oral health care to the general population, allowing treatment only for emergencies, because of the generation of aerosols during clinical procedures and to ration personal protective equipment (PPE) during the pandemic. | 2020-06-08 |
| 32511066 | We aimed to quantify the effect (if any) of the presence as opposed to absence of cancer on important clinical outcomes of patients with COVID-19 by carrying out a systematic review and meta-analysis. […] The synthesized evidence suggests that cancer is associated with worse clinical outcomes among patients with COVID-19. | 2020-06-17 |
| 32511078 | However, there is debate about what clinical measures should be used to make that determination and about other factors that might be ethically appropriate to consider. | 2020-06-08 |
| 32511678 | A single center study was conducted on 133 consecutive hypertensive subjects presenting to the Emergency Department with acute respiratory symptoms and/or fever who were diagnosed with COVID-19 infection between 9th and 31st March 2020. […] Our data suggest that chronic use of RAAS inhibitors does not negatively affect clinical course of COVID-19 in hypertensive patients. | 2020-06-26 |
| 32511692 | To describe the clinical and laboratory characteristics of hospitalized children who met criteria for the pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PIMS-TS) and compare these characteristics with other pediatric inflammatory disorders. […] Clinical and laboratory characteristics were abstracted by medical record review, and were compared with clinical characteristics of patients with Kawasaki disease (KD) (n = 1132), KD shock syndrome (n = 45), and toxic shock syndrome (n = 37) who had been admitted to hospitals in Europe and the US from 2002 to 2019. […] Signs and symptoms and laboratory and imaging findings of children who met definitional criteria for PIMS-TS from the UK, the US, and World Health Organization. […] Clinical, laboratory, and imaging characteristics of children meeting definitional criteria for PIMS-TS, and comparison with the characteristics of other pediatric inflammatory disorders. […] All children presented with fever and nonspecific symptoms, including vomiting (26/58 [45%]), abdominal pain (31/58 [53%]), and diarrhea (30/58 [52%]). […] Comparison of PIMS-TS with KD and with KD shock syndrome showed differences in clinical and laboratory features, including older age (median age, 9 years [IQR, 5.7-14] vs 2.7 years [IQR, 1.4-4.7] and 3.8 years [IQR, 0.2-18], respectively), and greater elevation of inflammatory markers such as C-reactive protein (median, 229 mg/L [IQR 156-338] vs 67 mg/L [IQR, 40-150 mg/L] and 193 mg/L [IQR, 83-237], respectively). […] In this case series of hospitalized children who met criteria for PIMS-TS, there was a wide spectrum of presenting signs and symptoms and disease severity, ranging from fever and inflammation to myocardial injury, shock, and development of coronary artery aneurysms. | 2020-06-16 |
| 32511724 | The COVID-19 pandemic has greatly impacted the daily clinical practice of cardiologists and cardiovascular surgeons. […] This Clinical Review provides an overview of COVID-19 and focuses on relevant aspects on prevention and management for specialists within the cardiovascular field. | 2020-06-23 |
| 32511784 | Coronavirus disease 2019 (COVID-19), a respiratory tract infection caused by a novel human coronavirus, the severe acute respiratory syndrome coronavirus 2, leads to a wide spectrum of clinical manifestations ranging from asymptomatic cases to patients with mild and severe symptoms, with or without pneumonia. […] There is no knowledge about the diagnosis and clinical management of the drug hypersensitivity reactions that can potentially occur during the disease. | 2020-06-19 |
| 32511867 | A population pharmacokinetic model was implemented to predict lung, intracellular poly/mononuclear cell (PBM/PML), and alveolar macrophage (AM) concentrations using published data and compared against preclinical EC90 for SARS-CoV-2. […] These data will better inform optimization of dosing regimens for azithromycin clinical trials. | 2020-06-19 |
| 32511971 | The characteristics of laboratory findings of coronavirus are of great significance for clinical diagnosis and treatment. | 2020-06-27 |
| 32512006 | A panel comprised of intensivists and interventional pulmonologists from three professional societies representing 13 institutions with experience in managing COVID-19 patients across a spectrum of healthcare environments developed key clinical questions addressing specific topics on tracheostomy in COVID-19. | 2020-06-11 |
| 32512110 | Significant healthcare disruption due to pandemic coronavirus disease 2019 (COVID-19) has implications across all aspects of clinical care in the United States (US). | 2020-06-11 |
| 32512122 | In our review of clinical studies, we found that in 26 studies including 11,685 patients, the weighted pooled prevalence of acute myocardial injury was 20% (ranged from 5% to 38% depending on the criteria used). […] In patients with elevated hs-troponin, clinical context is important and myocarditis as well as stress induced cardiomyopathy should be considered in the differential, along with type I and type II myocardial infarction. […] Clinical decisions including interventions should be individualized and carefully tailored after thorough review of risks/benefits. | 2020-06-11 |
| 32512133 | This retrospective, single-center cohort study was conducted to investigate the effects of sleep quality on recovery from lymphopenia and clinical outcomes in hospitalized patients with laboratory-confirmed COVID-19 admitted to the West District of Wuhan Union Hospital between January 25 and March 15, 2020. […] The epidemiological, demographic, clinical, laboratory, treatment, and outcome data were collected from electronic medical records and compared between the good-sleep group and poor-sleep group. | 2020-06-14 |
| 32512134 | The prevalence rates of depressive symptoms and post-traumatic stress disorder (PTSD) were 25.2% and 9.1%, respectively. […] Men were more likely to have depressive symptoms and PTSD than women. […] Those who were middle aged, worked for fewer years, had longer daily work time, and had lower levels of social support were at a higher risk of developing depressive symptoms and PTSD. […] Working in the Hubei province was associated with a higher risk of depressive symptoms, while those working in the Hubei province but residing in another province had a lower risk of depressive symptoms and PTSD. | 2020-06-15 |
| 32512240 | A systematic review of randomized controlled clinical trials on use of respiratory protection by healthcare workers, sick patients and community members was conducted. | 2020-06-17 |
| 32512244 | A survey consisting of 31 questions assessing changes to resident clinical and educational workload and their sentiment regarding how these changes might affect their careers was distributed electronically to neurosurgery residents in the United States and Canada. | 2020-06-21 |
| 32512263 | To analyze clinical characteristics and outcome of COVID-19 patients with underlying rheumatic diseases (RD) on immunosuppressive agents. | 2020-06-27 |
| 32512289 | Details of this hypothesis are in concordance with many clinical characteristics of COVID-19, including its predominant lethality for the elderly, and the mostly asymptomatic course of disease in children. | 2020-06-16 |
| 32512291 | METHODS: The PRAETORIAN-COVID trial is a multicenter, double-blind, placebo-controlled 1:1 randomized clinical trial in adult hospitalized SARS-CoV-2-infected patients (n = 651). | 2020-06-26 |
| 32512349 | We discuss two cases selected from patients requiring critical care in April 2020 in New York City with a unique clinical course. | 2020-06-26 |
| 32512357 | Respondents reported high levels of depression (43.3%, PHQ-8 scores ≥ 10), high anxiety scores (45.4%, GAD-7 scores ≥ 10), and high levels of PTSD symptoms (31.8%, PCL-C scores ≥ 45). […] High levels of loneliness, high levels of COVID-19-specific worry, and low distress tolerance were significantly associated with clinical levels of depression, anxiety, and PTSD symptoms. […] Resilience was associated with low levels of depression and anxiety symptoms but not PTSD. […] Compared to Whites, Asian Americans were less likely to report high levels across mental health symptoms, and Hispanic/Latinos were less likely to report high levels of anxiety. […] These factors provide initial guidance regarding the clinical management for COVID-19-related mental health problems. | 2020-06-23 |
| 32512491 | The pulmonary and cardiovascular systems are involved in any typical complications of COVID-19 but numerous other unrelated symptoms may occur. | 2020-06-26 |
| 32512493 | Fever, dry cough, dyspnea, myalgia, fatigue, loss of appetite, olfactory and gustatory dysfunctions are the most prevalent general symptoms. […] Leptin’s role in boosting proinflammatory cytokines and in appetite decreasing suggest the possible beneficial effect of decreasing the concentration of this proinflammatory adipose tissue hormone in relieving some symptoms detected during COVID-19 infection. | 2020-06-26 |
| 32512530 | Fever and cough are common symptoms only in infected individuals but headache and sleep disturbances are common even in uninfected general public. | 2020-06-27 |
| 32512532 | Gradually, it is seen that, many patients with COVID-19 infection have mild symptoms or are asymptomatic. | 2020-06-27 |
| 32512664 | Regarding symptoms at the time of diagnosis, cough (n=38, 35.2%) and fever (n=34, 31.5%) were most common; 12 cases (11.1%) were asymptomatic. | 2020-06-09 |
| 32512673 | However, the accurate pathophysiological mechanism of the disease, which progresses with various clinical presentations, is still substantially unknown. […] The clinical course of the disease is variable, with clinical representation ranging from 81% mild course to 14% severe course along with 5% critical course in patients. […] The disease progress with various symptoms, such as fever, cough, dyspnea, malaise, myalgia, taste and smell dysfunctions, diarrhea, and headache. | 2020-06-25 |
| 32512702 | Moreover we hereby aim to provide an overview of the possible consequences that COVID-19 may carry for the Central Nervous System (CNS) in People with MS (PwMS) and other demyelinating diseases, which are likely to pose challenges for treating Neurologists with respect to the long-term disease management of these diseases. | 2020-06-09 |
| 32512929 | KEGG pathway analysis revealed a number of critical pathways linked to the seven identified miRs that may provide insight into the interplay between the virus and comorbidities. | 2020-06-17 |
| 32512950 | Therefore, genomic sequencing and therapeutic clinical trials are being conducted to develop effective antiviral agents. | 2020-06-09 |
| 32513054 | As a result, students transitioning to residency encounter reduced clinical training experiences and decreased access to advising, mentorship, and research opportunities. […] The otolaryngology-head and neck surgery community has met these unprecedented challenges by producing diverse electronic resources for specialty-specific clinical education, as well as discussing ways to increase access to advising. | 2020-06-09 |
| 32513065 | In certain cases, chemosensory loss may be the only symptom of COVID-19 and may linger while other symptoms have resolved. […] These preliminary data demonstrate the persistence of self-reported smell loss despite otherwise clinical resolution and undetectable nasal viral RNA. | 2020-06-09 |
| 32513202 | Going forward through the increasingly large human trials for safety, dosage and efficacy, it will be vital to overlap work in parallel in the often challenging public policy and clinical tracks. | 2020-06-11 |
| 32513231 | Elimination criteria: 1)Patients whose clinical follow-up is lost or who decide not to continue in the study INTERVENTION AND COMPARATOR: The two management alternatives will be: Control - Hydroxychloroquine 200 mg taken orally every 12 hours for 7 days. | 2020-06-11 |
| 32513287 | Following the spread of the infection from the new SARS-CoV2 coronavirus in March 2020, several surgical societies have released their recommendations to manage the implications of the COVID-19 pandemic for the daily clinical practice. | 2020-06-23 |
| 32513289 | The patient should, in the PI’s opinion, be able to comply with all the requirements of the clinical trial (including home follow up during isolation). […] In the interest of public health and to contain transmission of infection, follow-up visits will be conducted in the participant’s home by a clinical trial team comprising nursing and medical members. […] Home visits will assess clinical and laboratory parameters of the patients. […] The clinical trial team and the patients will be blinded. […] The placebo will not be visibly identical, but it will be administered by staff not involved in the clinical care or participant follow up. | 2020-06-11 |
| 32513299 | Participating in other clinical research. | 2020-06-11 |
| 32513308 | This is a prospective, single-center, phase 2, randomized, controlled trial that is blinded to participants and clinical outcome assessor. […] Exclusion criteria include participation in another clinical trial of anti-viral agent(s)* for coronavirus disease-2019 (COVID-19), receipt of any anti-viral agent(s)* with possible activity against SARS-CoV-2 <24 hours prior to plasma infusion, mechanical ventilation (including extracorporeal membrane oxygenation [ECMO]) for ≥ 5 days, severe multi-organ failure, history of allergic reactions to transfused blood products per NHSN/CDC criteria, known IgA deficiency, and pregnancy. […] If donors have experienced COVID-19 symptoms within 28 days, they will be screened with a nasopharyngeal swab to confirm they are SARS-CoV-2 PCR-negative. […] The primary endpoint is time to clinical improvement. […] Death This scale, designed to assess clinical status over time, was based on that recommended by the World Health Organization for use in determining efficacy end-points in clinical trials in hospitalized patients with COVID-19. […] A recent clinical trial evaluating the efficacy and safety of lopinavir- ritonavir for patients hospitalized with severe COVID-19 used a similar ordinal scale, as have recent clinical trials of novel therapeutics for severe influenza, including a post-hoc analysis of a trial evaluating immune plasma. […] The blood bank and the clinical research team will not be blinded to group assignment. […] Among the participants, we expect ~70% or n = 72 will achieve clinical improvement. | 2020-06-23 |
| 32513346 | The limits could be attributed to the characteristics of the COVID-19 which is infectious even when the patients do not express any symptoms. | 2020-06-23 |
| 32513410 | We report here a case of the asymptomatic patient and present clinical characteristics of 455 contacts, which aims to study the infectivity of asymptomatic carriers. 455 contacts who were exposed to the asymptomatic COVID-19 virus carrier became the subjects of our research. […] We extracted their epidemiological information, clinical records, auxiliary examination results and therapeutic schedules. […] During the quarantine, seven patients plus one family member appeared new respiratory symptoms, where fever was the most common one. | 2020-06-22 |
| 32513427 | Training of medical students and residents is also suffering from this with the suspension of lectures and clinical rotations. | 2020-06-12 |
| 32513502 | We collected epidemiological information about «time» (date of onset of symptoms), «place» (zip code), and «person» (gender, age). | 2020-06-25 |
| 32513515 | In clinical practice, comprehensive care for COPD patients includes the diagnosis using spirometry, clinical examination and comprehensive pharmacological and non-pharmacological management. […] The diagnosis is based on symptoms, dyspnea and lung function impairment and can be mild to very severe. […] Symptoms are examined using the COPD assessment test (CAT) score, and dyspnea grade are examined using a modified MRC from GOLD guidelines. | 2020-06-12 |
| 32513532 | Thus, the World Health Organization (WHO) advised caution against COVID-19 for smokers and patients with underlying clinical symptoms, including cardiovascular diseases. | 2020-06-25 |
| 32513593 | To guide our clinical decisions at the National Cancer Institute of Milan (Lombardy region, the epicenter of the outbreak in Italy), we formulated Coronavirus-adapted institutional recommendations for the systemic treatment of patients with gastrointestinal cancers. […] Here, we describe how our daily clinical practice has changed due to the pandemic outbreak, with the aim of providing useful suggestions for physicians that are facing the same challenges worldwide. | 2020-06-12 |
| 32513664 | For 97.3% (182/187) of respondents COVID-19 affected or changed their respective clinical practice. | 2020-06-24 |
| 32513797 | The results of our preclinical study warrant further investigation and suggest it is worth evaluating whether suramin provides any benefit for COVID-19 patients, which obviously requires safety studies and well-designed, properly controlled randomized clinical trials. | 2020-06-09 |
| 32513807 | The authors outline the biologic plausibility, applicable clinical data, and potential role of each of these agents. | 2020-06-11 |
| 32513832 | There was extensive testing of workers in dormitories, segregation of healthy and infected workers, and daily observation for fever and symptoms. | 2020-06-09 |
| 32513858 | Molecular testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the gold standard for diagnosis of coronavirus disease 2019 (COVID-19), but the clinical performance of these tests is still poorly understood, particularly with regard to disease course, patient-specific factors, and viral shedding. […] The negative predictive value of the first day result among repeat-tested patients was 81.3% The clinical sensitivity of SARS-CoV-2 molecular assays was estimated between 58 % and 96%, depending on the unknown number of false negative results in single-tested patients. […] Conversion to negative was unlikely to occur before 15 to 20 days after initial testing or 20-30 days after the onset of symptoms, with 50% conversion occurring at 28 days after initial testing. […] In summary, our study provides estimates of the clinical performance of SARS-CoV-2 molecular assays and suggests time frames for appropriate repeat testing, namely 15 to 20 days after a positive test and the same or next 2 days after a negative test in patients with high suspicion for COVID-19. | 2020-06-09 |
| 32513859 | The role of serologic testing for SARS-CoV-2, both in the clinical and public health settings, will continue to evolve as we gain increasing insight into our immune response to the virus. […] (San Diego, CA), Euroimmun (Lubeck, Germany), and Ortho-Clinical Diagnostics (Rochester, NY), using a panel of serially collected serum samples (N=224) from 56 patients with confirmed COVID-19, healthy donor sera from 2018 and a cross-reactivity serum panel collected in early 2020. […] Sensitivity of the Abbott, Epitope, Euroimmun and Ortho-Clinical IgG assays in convalescent serum samples collected more than 14 days post symptom onset or initial positive RT-PCR result was 92.9% (78/84), 88.1% (74/84), 97.6% (82/84) and 98.8% (83/84), respectively. […] Among unique convalescent patients, sensitivity of the Abbott, Epitope, Euroimmun and Ortho-Clinical anti-SARS-CoV-2 IgG assays was 97.3% (36/37), 73% (27/37), 94.6% (35/37) and 97.3% (36/37), respectively. […] Overall assay specificity and positive predictive values based on a 5% prevalence rate are 99.6%/92.8%, 99.6%/90.6%, 98.0%/71.2% and 99.6%/92.5%, respectively, for the Abbott, Epitope, Euroimmun and Ortho-Clinical IgG assays. […] In conclusion, we show high sensitivity in convalescent sera and high specificity for the Abbott, Euroimmun and Ortho-Clinical anti-SARS-CoV-2 IgG assays. | 2020-06-09 |
| 32513860 | In addition, the massive global demand made it difficult to secure a reliable commercial supply of testing kits and reagents.A public health laboratory serves a unique and important role in the delivery of health care. | 2020-06-09 |
| 32513951 | Here, we update the recent understanding in clinical characteristics, diagnosis strategies, as well as clinical management of COVID-19 in China as compared to Italy, with the purpose to integrate the China experience with the global efforts to outline references for prevention, basic research, treatment as well as final control of the disease. | 2020-06-26 |
| 32514316 | Individualised correct prioritisation in the allocation of scarce resources is essential to good clinical practice. | 2020-06-11 |
| 32514354 | Many questions on the clinical management of COVID-19 remain unanswered, and data on corticosteroid therapy as a choice of treatment are mixed. […] We present the clinical course of our cases, review the previous evidence, and discuss management. | 2020-06-19 |
| 32514394 | To our knowledge, extrapulmonary clinical presentations of 2019 novel coronavirus disease (COVID-19) have rarely been reported. | 2020-06-11 |
| 32514399 | This report describes a case of Bacillus cereus bacteremia in a COVID-19 patient with prior inhalational steroid use and inpatient steroid treatment for COVID-19 pulmonary symptoms. | 2020-06-11 |
| 32514432 | Published clinical studies have supported that SARS-CoV-2 affects the GI tract and the liver. […] The largest published dataset comprised of 4243 patients and showed a pooled prevalence of GI symptoms at 17.6%. […] GI symptoms varied and usually preceded pulmonary symptoms by 1-2 days. | 2020-06-11 |
| 32514587 | Continuous scientific, clinical, and structural developments are necessary as the basis for the best care of the growing number of affected patients. […] This review summarizes current developments in the field of oncocardiology with regard to advances in cancer therapy and challenges in clinical oncocardiology work. | 2020-06-12 |
| 32514620 | Further, the clinical course of patients with aneurysmal subarachnoid hemorrhage (aSAH) and chronic subdural hematoma (cSDH) was investigated representatively for severe vascular and semi-urgent traumatic conditions that present with a wide variety of symptoms. […] For aSAH, the number of cases, aSAH grade, aneurysm localization, and treatment modality did not change but strikingly, elderly patients with cSDH presented less frequently, with more severe symptoms (p = 0.046), and were less likely to reach favorable outcome (p = 0.003) at discharge compared with previous years. […] Despite pandemic-related restrictive measures and reallocation of resources, patients with neuro-emergencies should be encouraged to present regardless of the severity of symptoms because deferred presentation may result in adverse outcome. | 2020-06-12 |
| 32514674 | The COVID-19 infection might complicate the clinical scenario of interstitial lung disease (ILD) in SSc because it determines a severe pneumonia characterized by radiological features similar to SSc-ILD. […] For these reasons, the rheumatologist in daily clinical practice should carefully differentiate the possible COVID-19 infection in order to optimize the patient management. | 2020-06-24 |
| 32514689 | Here, we conducted a systematic review to describe the drug repositioning strategy against SARS-CoV-2 and to discuss the clinical impact of this approach in the current pandemic context. […] Additionally, seven pharmacological agents (chloroquine, tetrandrine, umifenovir (arbidol), carrimycin, damageprevir, lopinavir/ritonavir) are in phase IV of clinical trials. | 2020-06-12 |
| 32514935 | Although further research on the influence of blood-pressure-lowering drugs, including those not targeting the renin-angiotensin system, is warranted, there are presently no compelling clinical data showing that ACEIs and ARBs increase the likelihood of contracting COVID-19 or worsen the outcome of SARS-CoV‑2 infections. | 2020-06-12 |
| 32515045 | We read with interest the correspondence from Montagud-Marrahi et al. putting forward that solid organ transplant (SOT) recipients are not at higher risk of severe COVID-19 infection despite their immunosuppression and the mild or atypical nature of their symptoms in their Spanish cohort. | 2020-06-19 |
| 32515076 | Clinical manifestations in non-transplant patients range from asymptomatic infection to severe pneumonia with acute respiratory distress syndrome, multiorgan system failure, and death. | 2020-06-23 |
| 32515085 | They had minimal symptoms at diagnosis and did not develop any respiratory complications or allograft dysfunction. | 2020-06-28 |
| 32515253 | Atrial fibrillation is a common clinical manifestation in hospitalized coronavirus disease of 2019 (COVID-19) patients. […] It is important for clinicians to be aware of these interactions, drug metabolism changes, and clinical consequences when choosing antiarrhythmic drugs and anticoagulants for COVID-19 patients with atrial fibrillation. | 2020-06-09 |
| 32515332 | This is a case report of a 42-year-old patient, who was admitted to hospital with clinical pneumonia. | 2020-06-15 |
| 32515363 | The objective of this study was to analyze the differences in psychopathological symptoms shown by Spanish general population during the COVID-19 quarantine based on sociodemographic, occupational and environmental-contextual variables. […] The Symptom Assessment-45 Questionnaire via online was used to measure the severity of psychopathology symptoms. […] The active or employed people presented lower values of depressive symptoms (t=2.10; p=0.04) than unemployed people. […] People who played sport daily reported a lower level of somatization symptoms (t=-2.11; p=0.03) than persons that did not play sport. | 2020-06-11 |
| 32515374 | Clinical manifestations can range from mild respiratory infections to fatal outcomes. | 2020-06-18 |
| 32515375 | COVID-19 poses a great challenge to clinical and diagnostic services around the world. […] The four pillars of biosafety namely, leadership, standard operating procedures, personal protective equipment (PPE) and engineering controls must be employed for effective and safe practices in the clinical setting in general and laboratory settings in particular. […] In our resource-poor settings, we need to adapt safe but cost-effective and improvised solutions to ensure safe handling of clinical samples from COVID-19 patients in the laboratories. […] Disinfection of the lab areas and safe disposal of the clinical samples from such patients is also of paramount importance. | 2020-06-18 |
| 32515376 | In this manuscript, the authors have detailed the unique aspects of the SARS-CoV-2 virus genome and its clinical implications. | 2020-06-18 |
| 32515377 | This commentary aims to provide a primary care perspective on existing clinical tools for cardiorespiratory assessment and rehabilitation. | 2020-06-18 |
| 32515378 | In a brief span of a few months, coronavirus disease (COVID-19) pandemic has brought a major paradigm shift in operation of clinical services around the world. […] Changes which are taking place in response to Covid-19 pandemic will have far reaching effects on clinical services in Pakistan. | 2020-06-18 |
| 32515379 | Anosmia and ageusia have recently been hinted as significant early symptoms in COVID-19. | 2020-06-18 |
| 32515380 | Heterogeneous clinical forms are described from asymptomatic to severe hypoxaemic acute respiratory syndrome with multisystem organ failure. […] In case of worsening clinical signs, hormonal biological monitoring must be done. | 2020-06-18 |
| 32515381 | While COVID- 19 typically presents as fever and respiratory illness, almost 50% of the patients also have associated digestive symptoms which vary from abdominal pain to diarrhoea and indigestion. […] Literature review of association of COVID- 19 with digestive symptoms was done using Google search and the results are presented herein. | 2020-06-18 |
| 32515382 | The COVID19 (Corona Virus Disease: pandemic started in 2019) pandemic has created not only a public health problem, but as a clinical challenge as well. […] To the cardiologist, COVID 19 presents a wide spectrum of possibilities for clinical decision-making intervention and improvement. | 2020-06-18 |
| 32515384 | Although most of the patients present with less severe symptoms like rhinitis, cough, fever, and mild flu-like symptoms, it may progress to severe acute respiratory illness, pneumonia or acute respiratory distress syndrome (ARDS) mainly in immunocompromised hosts. | 2020-06-18 |
| 32515385 | As knowledge about the disease epidemiology and clinical profile is rapidly evolving, we are still not sure about many different aspects of the disease transmission and presentation. | 2020-06-18 |
| 32515386 | The coronavirus disease (COVID-19) pandemic has influenced clinical care in unprecedented ways. | 2020-06-18 |
| 32515388 | Clinical features of this disease are variable, ranging from asymptomatic to critical disease. | 2020-06-18 |
| 32515396 | In the wake of an information avalanche, service and clinical practice challenge, service capacity challenge and above all, a unique and timely reminder of our own humanity and the inter-connectedness and fragility of human societies, we have endeavoured to identify and describe some crucial leadership facets, which are supporting our journey through this global health crisis. | 2020-06-18 |
| 32515397 | This evidence-based comprehensive literature review provides the role of nurses in the management of patients with COVID-19, which starts from the initial assessment and triaging, sample collection, care of patients with mild-to-moderate symptoms, care of the critically-ill patient, and care of the dead body. | 2020-06-18 |
| 32515404 | Here, we present an overview of the clinical trials that are currently being conducted or have concluded to date on COVID-19 globally. | 2020-06-18 |
| 32515499 | Eighteen patients were discharged, while six patients died, with no clinical or laboratory differences between the two groups at baseline. | 2020-06-19 |
| 32515500 | Studies have described clinical features of Covid-19 patients. […] However, limited data concerning the clinical characteristics of the Italian deaths are available. […] We aim to describe the clinical and epidemiological characteristics of 320 deceased from the Italian experience. […] Clinical history, comorbidities, laboratory findings and treatment were recorded for each patient. | 2020-06-19 |
| 32515518 | We reported previously on the successful containment of this outbreak and characterized the clinical symptoms and immunoglobulin development in staff members exposed to SARS-CoV-2.4-5. | 2020-06-19 |
| 32515544 | Clinical decision-making in kidney transplantation (KT) during the COVID-19 pandemic is understandably a conundrum: both candidates and recipients may face increased acquisition risks and case fatality rates (CFRs). | 2020-06-25 |
| 32515555 | Two patients tested positive for SARS-CoV-2 and 14.6% reported symptoms. | 2020-06-19 |
| 32515642 | Delays and cancellation of clinical rotations have forced medical students to pursue opportunities outside of the traditional learning paradigm. | 2020-06-09 |
| 32515676 | Acute myocarditis occurred less than 1 week after onset of fever and gastrointestinal symptoms. | 2020-06-16 |
| 32515698 | Information about the epidemiology, etiology, pathogenesis, clinical and laboratory diagnostics, as well as prevention and therapy for this disease is constantly being expanded and reviewed. | 2020-06-17 |
| 32515699 | The authors presented state-of-the-art insight into hemostatic disorders in patients with COVID-19 and clinical recommendations on prevention of thrombosis and thromboembolism in patients infected with SARS-CoV-2. | 2020-06-17 |
| 32515982 | Preclinical studies and clinical trials with slow-releasing H2S donor(s) or the activators of endogenous H2S-generating enzymes should be considered as a preventative treatment or therapy for COVID-19. | 2020-06-09 |
| 32516070 | The CVC continues to address patients’ concerns and symptoms in an effort to minimize emergency department and hospital patient volumes, as incidence increases. | 2020-06-09 |
| 32516107 | Currently, it is important to bear in mind the COVID-19 infection in evaluating the patients with respiratory symptoms. […] This report indicated how misleading the presentation of chest CT scan could be in clinical judgment. | 2020-06-09 |
| 32516204 | Gastrointestinal symptoms are common and frequently reported in Coronavirus Disease-2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] In this case series, we attempt to discuss the important clinical implications related to the management of GIB in COVID-19 patients. | 2020-06-19 |
| 32516274 | Clinical trials have demonstrated beneficial effects of early prone positioning for acute respiratory distress syndrome (ARDS), including decreased mortality. […] The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is responsible for the clinical manifestations of COVID-19. | 2020-06-09 |
| 32516279 | Initially, a screening questionnaire consisting of relevant signs and symptoms (e.g., fever, cough, shortness of breath) or exposure dictated the need for nasopharyngeal swab real-time quantitative polymerase chain reaction (RT-PCR) testing for all admitted patients. […] The negative predictive value of using the signs and symptoms of disease to predict a negative test result was 91.4% (95% confidence interval [CI], 81.0% to 97.1%). | 2020-06-10 |
| 32516281 | Published reports of adult patients with COVID-19 infection described symptoms including fever, cough, fatigue, sputum production, headache, dyspnoea and diarrhoea. […] Children usually showed milder respiratory symptoms or were asymptomatic, while loss of taste or sensation of smell were seldom reported. | 2020-06-09 |
| 32516421 | However, because COVID-19 rehabilitation units are a clinical novelty, clinical and organizational benchmarks are not yet available. […] This study shows that COVID-19 rehabilitation units must be organized following specific clinical and organizational needs. | 2020-06-09 |
| 32516704 | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) and its clinical manifestation, the coronavirus disease 2019 (COVID19) have rapidly spread across the globe, leading to the declaration of a pandemic. […] While most present mild symptoms, it appears as though nearly 20% of confirmed patients develop significant complications. […] In this review we will discuss the impact of COVID-19 on patients affected by cancer, their diagnosis and management, as well as the pathophysiology of COVID-19 induced acute respiratory distress symptoms and currently investigated treatment approaches. | 2020-06-19 |
| 32516739 | The analytical and clinical performances of LightMix® Modular SARS and Wuhan CoV E-gene kit, a widely used commercial assay for SARS-CoV-2 detection, have not been well studied. […] A total of 289 clinical specimens from 186 patients with suspected COVID-19 and 8 proficiency testing (PT) samples were used to evaluate the diagnostic performance of the LightMix® E-gene kit against in-house developed COVID-19-RdRp/Hel and COVID-19-N RT-PCR assays. | 2020-06-26 |
| 32516750 | In total, 5104 people responded to the question about severe symptoms, from which 242 indicated to suffer from severe symptoms. […] A total of 4929 people responded to the question about mild symptoms, from which 3248 indicated to suffer from these. […] Furthermore, the data was linked to clinical data. | 2020-06-26 |
| 32516772 | The coronavirus disease (COVID-19 or 2019-nCoV) often involves mild clinical symptoms but in some cases, it can lead to pneumonia with acute respiratory distress syndrome and multiorgan dysfunction. | 2020-06-09 |
| 32516797 | While many investigational, approved, and repurposed drugs have been suggested, preclinical data from animal models can guide the search for effective treatments by ruling out treatments without in vivo efficacy. […] Remdesivir (GS-5734) is a nucleotide analog prodrug with broad antiviral activity1,2, that is currently investigated in COVID-19 clinical trials and recently received Emergency Use Authorization from the US Food and Drug Administration3,4. […] Thus, therapeutic remdesivir treatment initiated early during infection had a clinical benefit in SARS-CoV-2-infected rhesus macaques. | 2020-06-09 |
| 32516833 | The primary endpoint was the incidence of laboratory-confirmed COVID-19 diagnosis or new symptoms requiring self-isolation or hospitalisation after a tracheal intubation episode. | 2020-06-19 |
| 32516836 | The challenge is to define the next generation of interconnectivity tools that would be necessary to achieve a new operational model that, while ensuring low face-to-face interaction between the main players of the diagnostic pipeline, allows maximum interconnectivity to serve our patients and the immediate teaching and research needs associated with clinical tissue/cellular samples. | 2020-06-19 |
| 32516839 | We summarized clinical studies and other research data available as of May 5, 2020, on CCP therapy according to the Clinical Treatment Guideline of COVID-19 Convalescent Plasma in China, as well as clinical experience at the First Affiliated Hospital of Zhejiang University, as part of a comprehensive anti-epidemic strategy. […] Sources of clinical and methodological heterogeneity were identified. […] We identified three clinical studies for COVID-19 in China. […] Analyses showed a statistically significant improvement in clinical outcomes compared with untreated cases (P<0.001). | 2020-06-19 |
| 32516847 | Data on prevalence, relevance of the novel virus, and clinical course of the infection in stable LT patients are limited. | 2020-06-22 |
| 32516853 | One example is the creation of the CTAP (Coronavirus Treatment Acceleration Program) by the FDA (U.S Foods And Drugs Administration) to support clinical trials. | 2020-06-19 |
| 32516861 | The aim of the present study was to describe the clinical presentation of patients aged ≥80 years with coronavirus disease 2019 (COVID-19), and provide insights regarding the prognostic factors and the risk stratification in this population. […] We reviewed the clinical records of patients consecutively admitted for confirmed COVID-19 over a 1-month period (1-31 March 2020). | 2020-06-19 |
| 32516940 | COVID-19 is a viral disease that can affect every age group-from infants to the elderly-resulting in a wide spectrum of various clinical manifestations. […] Fever, dry cough, muscle weakness, and chest pain are the most prevalent and typical symptoms of COVID-19. […] However, patients might also present atypical symptoms that can occur alone, which might indicate the possible SARS-CoV-2 infection. […] The aim of this paper is to review and summarize all of the findings regarding clinical manifestations of COVID-19 patients, which include respiratory, neurological, olfactory and gustatory, gastrointestinal, ophthalmic, dermatological, cardiac, and rheumatologic manifestations, as well as specific symptoms in pediatric patients. | 2020-06-11 |
| 32517294 | Negative changes in physical activity, sleep, smoking and alcohol intake were associated with higher depression, anxiety and stress symptoms. | 2020-06-16 |
| 32517353 | As a direct inhibitor of STAT3-a master checkpoint regulator of inflammatory cytokine signaling and immune response-silibinin might be expected to phenotypically integrate the mechanisms of action of IL-6-targeted monoclonal antibodies and pan-JAK1/2 inhibitors to limit the cytokine storm and T-cell lymphopenia in the clinical setting of severe COVID-19. […] The dual ability of silibinin to target both the host cytokine storm and the virus replication machinery provides a strong rationale for the clinical testing of silibinin against the COVID-19 global public health emergency. […] A randomized, open-label, phase II multicentric clinical trial (SIL-COVID19) will evaluate the therapeutic efficacy of silibinin in the prevention of acute respiratory distress syndrome in moderate-to-severe COVID-19-positive onco-hematological patients at the Catalan Institute of Oncology in Catalonia, Spain. | 2020-06-11 |
| 32517769 | These ‘pure’ cases differ in the time of presentation of symptoms, the phase of lung anatomopathological patterns (acute lung injury versus diffuse alveolar damage) and the mechanism of death. | 2020-06-17 |
| 32517803 | There is no clinical evidence that SMT improves human immunity. | 2020-06-18 |
| 32517815 | However, as the knowledge on the disease progresses, clinical evidence showed that children mainly have asymptomatic or mild disease and it has been suggested that they are also less likely to spread the virus. | 2020-06-22 |
| 32517963 | After adjusting for disease severity and relevant clinical factors, even small amounts of myocardial injury (e.g. troponin I 0.03-0.09ng/mL, n=455, 16.6%) were significantly associated with death (adjusted HR: 1.75, 95% CI 1.37-2.24; P<0.001) while greater amounts (e.g. troponin I>0.09 ng/dL, n=530, 19.4%) were significantly associated with higher risk (adjusted HR 3.03, 95% CI 2.42-3.80; P<0.001). | 2020-06-12 |
| 32518045 | The aim of this study was to describe severe forms of novel coronavirus disease 2019 in children, including patient characteristics, clinical, laboratory, and imaging findings, as well as the disease management and outcomes. […] This study highlighted the large spectrum of clinical presentation and time course of disease progression as well as the non-negligible occurrence of pediatric life-threatening and fatal cases of COVID-19 mostly in patients with comorbidities. | 2020-06-17 |
| 32518071 | They were asymptomatic (n=2), had mild (n=37) or severe symptoms requiring hospitalization in medical (n=35) or intensive care unit (n=28). […] Sensitivity of OG was 95.8% (CI95% 89.6-98.8) for samples collected ≥10 days after onset of symptoms which was equivalent to sensitivity of ASIA of 90.5% (IC95% 82.8-95.6). […] Overall, OG performance characteristics indicate that the test is suitable for routine use in clinical laboratories and performance is equivalent to immunoassay. | 2020-06-10 |
| 32518072 | However, the correlation between detectable viral RNA and culturable virus in clinical specimens remains unclear. […] Overall, these results indicate that in addition to the copy number, the integrity of the viral genome should be considered when evaluating the infectivity of clinical SARS-CoV-2 specimens. | 2020-06-10 |
| 32518075 | To identify pandemic and disaster medicine-themed training programmes aimed at medical students and to assess whether these interventions had an effect on objective measures of disaster preparedness and clinical outcomes. […] No studies assessed clinical improvement. | 2020-06-27 |
| 32518102 | Where face-to-face outpatient appointments have been cancelled, telemedicine can facilitate remote clinical consultations for new and follow-up epilepsy clinic patients while reducing the risk of infection to both patients and healthcare staff. […] First-seizure patients will need investigation pathways rationalised, while those with chronic epilepsy will need to have reliable alternative avenues to access clinical advice. […] Ultimately, the revolution in our clinical practice is unlikely to cease after this pandemic, with reconfiguration of services likely to bring improvements in efficiency and convenience, and a reduced environmental impact. | 2020-06-10 |
| 32518103 | Patients with coronavirus disease 2019 (COVID-19) typically present with respiratory symptoms, but little is known about the disease’s potential neurological complications.We report a case of Guillain-Barré syndrome (GBS) following a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, in association with leptomeningeal enhancement. | 2020-06-10 |
| 32518104 | Many non-emergency clinical services were suspended during COVID-19 pandemic peak. […] Key recommendations include the following: all patients should have need for endoscopy assessed by senior clinicians and prioritised according to criteria we have outlined; once the need for endoscopy is confirmed, patients should undergo telephone screening for symptoms using systematic questionnaires; all outpatients should undergo RT-PCR testing for COVID-19 virus 1-3 days prior to endoscopy; and PPE should be determined by patient risk stratification, the nature of the procedure and the results of testing. | 2020-06-10 |
| 32518134 | In this consult, we discuss 5 types of moral distress using examples of changes to clinical practice that have occurred due to COVID-19. | 2020-06-10 |
| 32518172 | Eleven GBS cases in four key COVID-19 hotspots are discussed regarding presenting symptoms, response to therapies and cross-reactivity of COVID spike proteins with nerve glycolipids. […] Collective data indicate that in this pandemic any patient presenting with an acute paralytic disease-like GBS, encephalomyelitis or myositis-even without systemic symptoms, may represent the first manifestation of COVID-19. | 2020-06-25 |
| 32518212 | We aimed to characterise registered clinical trials assessing drugs or plasma treatments for COVID-19. […] Cross-sectional analysis of clinical trials for the treatment of COVID-19 that were registered in the USA or in countries contributing to the WHO’s International Clinical Trials Registry Platform. […] Trial intervention, sponsorship, critical design elements and specified outcomes RESULTS: Overall, 201 clinical trials were registered for testing the therapeutic benefits of 92 drugs or plasma, including 64 in monotherapy and 28 different combinations. […] Clinical endpoints were identified in 134 (66.7%) of trials and included COVID-19 symptoms, death, recovery, required intensive care and hospital discharge. […] Clinical scales were being used in 33 (16.4%) trials, most often measures of oxygenation and critical illness. […] While accelerating morbidity and mortality from the COVID-19 pandemic has been paralleled by early and rapid clinical investigation, many trials lack features to optimise their scientific value. | 2020-06-23 |
| 32518419 | Retrospective analysis of CIS reduction and clinical outcome was performed. […] A total of 12/14 patients achieved significant reduction of CIS by ≥25% on day 7 with sustained clinical improvement in 11/14 patients without short term red flag warnings of Rux-induced toxicity. […] A multicenter phase-II clinical trial has been initiated (NCT04338958). | 2020-06-13 |
| 32518475 | Our model includes two additional states of an individual, confined and quarantined, which are reached when an individual presents COVID-19 symptoms or has undergone a virus test with a positive result. | 2020-06-12 |
| 32518555 | In this review, the early use of TCM for light and ordinary patients, can rapidly improve symptoms, shorten hospitalization days and reduce severe cases transformed from light and normal. […] The TCM theoretical system of treating epidemic diseases with TCM and the treatment scheme of integrated Chinese and Western medicine have proved their effectiveness in clinical practice. | 2020-06-12 |
| 32518636 | Currently, thousands of new COVID-19 patients are quickly enrolled in clinical studies. […] In the COVID-19 pandemic era, it is crucial that the adoption of new diagnostic, preventive and therapeutic strategies is based upon evidence coming from well-designed, adequately powered and carefully conducted clinical trials. | 2020-06-17 |
| 32518738 | The IACS appeared to contain the aerosolized mist, while the intubation box allowed for mist to contact the laryngoscopist and contaminate the clinical space through arm port holes and the open caudal end. | 2020-06-12 |
| 32518767 | We also report French experience in a COVID-19 cluster region illustrated by two clinical cases. | 2020-06-12 |
| 32518804 | We aimed to investigate the correlation between chest CT and clinical features in COVID-19 suspected patients with or without fever. […] The performance of CT in patients with relevant onset of symptoms, with fever (n = 141) and without fever (n = 70), was assessed respectively. | 2020-06-11 |
| 32518902 | Of the 7 patients, 5 presented with symptoms of coronavirus disease 2019, including cough, myalgias, fevers, chest pain, and headache. | 2020-06-12 |
| 32518987 | To determine the consistency between CT findings and real-time reverse transcription-polymerase chain reaction (RT-PCR) and to investigate the relationship between CT features and clinical prognosis in COVID-19. […] The clinical manifestations, laboratory parameters, and CT imaging findings were analyzed in 34 COVID-19 patients, confirmed by RT-PCR from January 20 to February 4 in Hainan Province. | 2020-06-13 |
| 32518989 | Relevant clinical and laboratory data and CT scan findings were collected for each patient. […] Clinical classification, lung involvement of COVID-19 pneumonia, and CT total severity score were compared between APE group and non-APE group. […] There was no significant difference between APE and non-APE groups concerning clinical type, COVID-19 pneumonia lung lesions (ground-glass opacity: 85% vs. 97%; consolidation: 69% vs. 68%; crazy paving: 38% vs. 37%; linear reticulation: 69% vs. […] The presence of APE was not limited to severe or critical clinical type of COVID-19 pneumonia. […] • Five of 13 (38%) patients with acute pulmonary embolism had a moderate clinical type. | 2020-06-13 |
| 32519136 | For all the above-mentioned reasons, it is possible that some clinical conditions will further progress with a significant increase in morbidity and mortality. | 2020-06-12 |
| 32519150 | Growing numbers of SARS-CoV-2 cases coupled with limited understanding of transmissibility and virulence, have challenged the current workflow and clinical care pathways for the dysphagia provider. […] The objective of this review was to create a clinical algorithm and reference for dysphagia clinicians across clinical settings to minimize spread of COVID-19 cases while providing optimal care to patients suffering from swallowing disorders. | 2020-06-13 |
| 32519256 | The purpose of this study is to describe the main chest radiological features (CXR) of COVID-19 and correlate them with clinical outcome. […] This is a retrospective study involving patients with clinical-epidemiological suspect of COVID-19 infection, who performed CXRs at the emergency department (ED) of our University Hospital from March 1 to March 31, 2020. […] All patients performed RT-PCR nasopharyngeal and throat swab, CXR at the ED and clinical-epidemiological data. | 2020-06-13 |
| 32519293 | However, extracardiac findings are frequently detected on these examinations and often can explain patients’ underlying symptoms, having a significant impact on patient management. | 2020-06-13 |
| 32519302 | An increasing number of experimental animal studies and early clinical studies verify the safety and efficacy of MSC therapy in ARDS. | 2020-06-13 |
| 32519383 | The Covid-19 pandemic has led to widespread disruptions in the clinical education of medical students. […] In managing students’ return to the clinical setting, medical schools face the challenge of balancing education, service, and risk considerations. […] Understanding students’ views on resuming clinical experiences, therefore, is an important consideration. […] The purpose of this study was to assess medical students’ preference for re-entering the clinical setting during a pandemic, and to explore personal and environmental characteristics associated with that preference. […] Survey items were aligned with a conceptual framework related to medical students’ preference for returning to the clinical setting. […] Approximately one third of 179 students preferred not to return to the clinical setting. […] Students’ preference regarding return to the clinical environment stems from the interplay of several key factors, and is substantively associated with perceptions of professional responsibility and their own potential risk to the healthcare system. […] Mindfully considering and addressing these issues may help medical schools in their preparation for returning students to the clinical setting. | 2020-06-19 |
| 32519406 | Here, we present a 62-year old male COVID-19 patient with recent heart transplantation who developed only mild symptoms, but had prolonged virus shedding, and summarize the available data on COVID-19 in cardiac allograft recipients. […] Initially the patient presented with a transient episode of fever and sore throat but no other symptoms, in particular no cough or dyspnea at rest. […] While the patient had no clinical symptoms anymore 20 days after initial presentation, virus culture of throat swabs on days 18 and 21 confirmed active virus replication and SARS-CoV-2 PCR remained positive on day 35 with copy numbers similar to the onset of infection. […] In conclusion, immunosuppression regimen in transplant recipients with mild COVID-19 associated symptoms may be continued unchanged. | 2020-06-19 |
| 32519618 | We retrospectively collected patient demographic characteristics, clinical data, and immunological factors affecting the clinical course of the disease. | 2020-06-24 |
| 32519636 | From a clinical perspective, the overall gap between the measured and the self-reported BMI (M = 1.43, SD = 2.72), which represents an absolute gap of 0.74 kilograms and 2.95 centimeters, is expected to have only a mild influence on the physician’s clinical evaluation of the patient’s medical condition. | 2020-06-27 |
| 32519753 | We hope our hypothesis, corroborated by several preclinical evidence, will inspire further targeted studies to test CBD as a support drug against the COVID-19 pandemic. | 2020-06-19 |
| 32519768 | Herein, we present clinical features and outcomes of six COVID-19 patients who had developed hyperpyrexia during hospitalization. | 2020-06-19 |
| 32519809 | The most common symptoms and signs were fever (53%, 95% CI: 45%-61%), cough (39%, 95% CI: 30%-47%), and sore throat/pharyngeal erythema (14%, 95% CI: 4%-28%); however, 18% (95% CI: 11%-27%) of cases were asymptomatic. […] Previously healthy children with COVID-19 have mild symptoms. | 2020-06-19 |
| 32519827 | Percentage of subjects who answered correctly regarding main symptoms of COVID-19 and primary mode of transmission was 87% and 82.5% respectively. | 2020-06-22 |
| 32519894 | Coronavirus Disease 2019 (COVID-19), the clinical syndrome associated with infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has impacted nearly every country in the world. […] Additionally, we review preclinical evidence establishing biological plausibility for heparin and synthetic heparin-like drugs as therapies for COVID-19 through anti-viral and anti-inflammatory effects. | 2020-06-10 |
| 32519921 | The patient’s symptoms subsided after few days. | 2020-06-19 |
| 32519944 | A comparative presentation of the clinical features of the first 50 COVID-19 patients with and without acute respiratory distress syndrome (ARDS) who were hospitalized in the University Hospital Aachen. 24 intubated patients were treated in the intensive care unit for ARDS of varying degrees of severity, while 26 patients who were breathing spontaneously without ARDS, but nevertheless needed supplemental oxygen, were treated in a separate isolation ward. | 2020-06-17 |
| 32519953 | The purpose of this review is to provide information addressing questions and concerns about COVID-19, to reveal the effects of the novel disease on patients with chronic liver disease and LT recipients, and to share information about ways in which this pandemic will affect clinical practices. | 2020-06-23 |
| 32519963 | During the first academic term impacted by COVID-19 (Winter 2020), individuals were more sedentary and reported increased anxiety and depression symptoms (P<.001) relative to previous academic terms and subsequent academic breaks. | 2020-06-23 |
| 32519978 | The aim of this study was to evaluate the effectiveness of plants used in the formulations of traditional Chinese medicine (TCM), which were also used in clinical trials to treat patients with the novel coronavirus COVID-19, and to assess their effects on the cardiovascular system. […] The mechanism of action, cardiovascular effects, and possible toxicity of 10 plants frequently found in TCM formulations that were used in the clinical treatment of COVID-19 were examined. […] Despite the effectiveness seen in laboratory and animal studies with the most commonly used plants in these formulations, the clinical studies are currently insufficient according to standard operating procedures. […] More clinical studies are needed to understand the safe clinical use of traditional plants. | 2020-06-24 |
| 32520071 | There is no randomized controlled clinical trial addressing potential therapies for patients with confirmed COVID-19 infection at the time of publishing these treatment recommendations. | 2020-06-15 |
| 32520083 | Medicine can be broadly divided into two fields: clinical medicine that aims to save existing patients and basic medical research that aims to save the lives of future patients. | 2020-06-15 |
| 32520155 | We have installed a COVID-19 Management Committee to elaborate and implement best practices to assist cancer outpatients as well as to provide a safe environment for clinical staff and other employees at the outpatient clinics. […] The challenges of cancer treatment in the midst of COVID-19 global pandemic highlight the importance of a rapid response by institutions, where organizational structure, strategic planning, agility in guidelines implementation and alternative ways to protect and support clinical staff, employees and patients may be the key to mitigate pandemic effects. | 2020-06-15 |
| 32520160 | The present study aimed to review the epidemiology, clinical manifestation, laboratory diagnosis, treatment, and future perspectives related to COVID-19 infections. […] The clinical course of COVID-19 is still not clear, although the SARS-CoV-2 infection seems to develop with mild, influenza-like symptoms in the vast majority of subjects, i.e., 10%-15% of COVID-19 patients. | 2020-06-15 |
| 32520284 | The number of confirmed cases, as April 11, surpassed 1,700,000, but this figure does not reflect the prevalence of COVID-19 in the population as, in many countries, tests are almost exclusively performed in people with symptoms, particularly severe cases. […] Our study is aimed at estimating the prevalence of infected individuals in the state of Rio Grande do Sul, Brazil, to document how fast the infection spreads, and to estimate the proportion of infected persons who present or presented symptoms, as well as the proportion of asymptomatic infections. | 2020-06-17 |
| 32520293 | Due to difficulties in diagnosing this infection in populations around the world, initiatives supported by digital technologies are being developed by governments and private companies to enable the tracking of the public’s symptoms, contacts and movements. | 2020-06-17 |
| 32520311 | The severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]-causing coronavirus disease [COVID]-19 pandemic poses major challenges for patients with inflammatory bowel disease to be recruited and maintained in clinical trials. […] However, clinical trials offer patients who have failed multiple drugs access to study medications with alternative mode of action and the potential for relief from inflammation-mediated symptoms. […] Therefore, the continuation of clinical trials in IBD during the COVID-19 pandemic is important both for participants and the community of IBD patients, due to the dire need of an expanded therapeutic armamentarium. […] As the safety of patients in clinical trials is the leading principle, we are providing ten specific rules to guide patients and principal investigators safely through the challenging time. | 2020-06-26 |
| 32520312 | Although clinical, immunological and pharmacological data from the experience with the previous coronavirus outbreaks cannot be automatically translated to predict the safety of IBD therapies during COVID-19 pandemic, the signals so far from these outbreaks on IBD patients who are on immunomodulators and biologics are reassuring to patients and clinicians alike. | 2020-06-26 |
| 32520340 | Our clinical laboratory and diagnostic infrastructure are capable of incorporating required volumes for many local, regional, and national public health surveillance studies into their current and projected testing capacity. | 2020-06-26 |
| 32520401 | It typically presents with respiratory symptoms and febrile illness. | 2020-06-19 |
| 32520406 | We developed a predictive model for COVID-19 diagnosis based on lung ultrasound and clinical features. | 2020-06-19 |
| 32520507 | Given the high clinical suspicion for COVID-19, the patient was isolated and repeat RT-PCR was positive at 72 hours. | 2020-06-19 |
| 32520508 | However, early diagnosis may be challenging, especially in cancer patients under treatment with immunotherapy as drug-induced pneumonitis can present similar clinical and radiological features. | 2020-06-19 |
| 32520514 | In the current state of COVID-19 pandemic, a high prevalence of incidental pneumonia may be expected, even with previous clinical triage, explained by a nondefined number of patients who were asymptomatic or minimally symptomatic for infectious process. | 2020-06-19 |
| 32520599 | Chronic mucosal use up to 5% has not been shown to result in clinical thyroid disease. | 2020-06-10 |
| 32520683 | After the publication of hydroxychloroquine (HCQ) with anti-SARS-COV-2 activity in vitro, a small, non-randomized, open-label clinical trial showed that HCQ treatment was significantly associated with reduced viral load in patients with coronavirus disease-19 (COVID-19). […] Use the keyword ‘Hydroxychloroquine’ to conduct a literature search in PubMed to collect relevant literature on the mechanism of action of HCQ, clinical efficacy and safety, pharmacokinetic characteristics, precautions for clinical use and drug interactions, and extract and organize information. […] This paper reviews the mechanism, clinical efficacy and safety, pharmacokinetic characteristics, exposure-response relationship and precautions and drug interactions of HCQ, and summarized dosage recommendations for HCQ sulfate. […] It has been proved that HCQ, which has an established safety profile, is effective against SARS-CoV-2 with sufficient pre-clinical rationale and evidence. […] Data from high-quality clinical trials are urgently needed worldwide. | 2020-06-10 |
| 32520728 | This study assessed the incidence of COVID-19-like symptoms and presence of COVID-19 antibodies after work-related COVID-19 exposures, among physicians working in a large academic hospital in New York City (NYC). […] The survey assessed 4 domains: 1) demographics and medical history, 2) community exposure to COVID-19 (e.g., use of NYC subway), 3) work-related exposure to COVID-19, and 4) development of COVID-19-like symptoms after work exposure. […] Based on the clinical scenario, work exposure was categorized as high-risk (e.g., exposure during intubation) or low-risk (e.g., exposure during doffing). 205 healthcare providers were contacted and 105 completed the survey (51%); 91 completed the serological test. […] Among respondents reporting a work-related exposure, 16 (26.2%) reported post-exposure COVID-19-like symptoms. […] The most frequent symptoms were myalgia (9 cases), diarrhea (8 cases), fever (7 cases), and sore throat (7 cases). […] Compared with antibody negative respondents, antibody positive respondents were more likely to use NYC subway to commute to work and report COVID-19-like symptoms in the last 90 days. […] In the epicenter of the United States’ pandemic and within 6-8 weeks of the COVID-19 outbreak, a small proportion of anesthesiologists and affiliated intensive care providers reported COVID-19-like symptoms after a work-related exposure and even fewer had detectable COVID-19 antibodies. | 2020-06-19 |
| 32520747 | In this review, we summarize recent studies using digital technology to manage symptoms and support clinical care for this patient population and discuss new opportunities to advance digital psychiatry research and practice in LMICs. […] Studies evaluating digital interventions for clinical populations living with SMDs in LMICs are limited. […] Continued rigorous research evaluating effectiveness and cost-effectiveness of digital technologies in reaching, treating, and managing symptoms and supporting clinical care for patients with SMDs in LMICs is vital. | 2020-06-10 |
| 32520750 | The COVID-19 outbreak has sown clinical and administrative chaos at academic health centers throughout the country. | 2020-06-19 |
| 32520888 | To describe the characteristics of clinical manifestations of children with 2019 novel coronavirus (2019-nCoV) infection in Chongqing. […] Clinical data and epidemiologic history of these patients were retrospectively collected and analyzed. […] These patients could be categorized into different clinical types, including 8 (32%) asymptomatic, 4 (16%) very mild cases and 13 (52%) common cases. […] The most common symptoms were cough (13 cases, 52%) and fever (6 cases, 24%). […] The duration time of clinical symptoms was 13.0 (8.0-25.0) days. […] The morbidity of 2019-nCoV infection in children is lower than in adults and the clinical manifestations and inflammatory biomarkers in children are nonspecific and milder than that in adults. | 2020-06-26 |
| 32521039 | To summarize for the trainee audience the possible mechanisms of headache in patients with COVID-19 as well as to outline the impact of the pandemic on patients with headache disorders and headache medicine in clinical practice. […] COVID-19 is a global pandemic caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2, of which a large subset of patients features neurological symptoms, commonly headache. […] The virus is highly contagious and is, therefore, changing clinical practice by forcing limitations on in-person visits and procedural treatments, more quickly shifting toward the widespread adaptation of telemedicine services. | 2020-06-20 |
| 32521062 | Typical symptoms include fever, cough, and shortness of breath. | 2020-06-19 |
| 32521074 | Management of lung transplant recipients can be particularly challenging given high levels of maintenance immunosuppression, high incidence of rejection, constant exposure of the graft to the external environment, and diagnostic uncertainty in patients with respiratory symptoms. | 2020-06-19 |
| 32521159 | Recently, because of its positive results in clinical trials, remdesivir was approved by the Food and Drug Administration to treat COVID-19 through Emergency Use Authorization. | 2020-06-25 |
| 32521191 | Across the world, a surge of clinical trials trying to cure or slow down the coronavirus pandemic has been launched to bring hope instead of fear and despair. […] One first proposed clinical trial has drawn worldwide hype to the benefit of chloroquine (CQ), in the treatment of patients infected by the recently emerged deadly coronavirus (SARS-CoV-2). | 2020-06-19 |
| 32521358 | The primary objective of the Scleroderma Patient-centered Intervention Network COVID-19 Home-isolation Activities Together (SPIN-CHAT) Trial is to evaluate the effect of a videoconference-based program on symptoms of anxiety. […] Secondary objectives include evaluating effects on symptoms of depression, stress, loneliness, boredom, physical activity, and social interaction. | 2020-06-27 |
| 32521557 | Several studies, particularly from Europe and the USA, have now confirmed these symptoms as an early key feature of COVID-19. […] Some reports associate olfactory disorders with a milder clinical course. […] At the same time, the olfactory system via the olfactory bulb represents an entry point into the central nervous system, and an olfactory disorder could be a predisposing factor for central neurological symptoms. […] The clinical significance of smell and taste disorders in COVID-19 patients is currently still unclear. | 2020-06-10 |
| 32521580 | This expert consensus, proposed by the Chinese Society of Nephrology and the Nephrology Committee of Chinese Research Hospital Association, is to guide and standardize the clinical application of blood purifications in the treatment of severe or critical patients with COVID-19. | 2020-06-10 |
| 32521643 | Hence, we conducted a nationwide survey to assess clinical characteristics and outcomes in patients with congenital heart disease affected by COVID-19. […] Cardiovascular symptoms such as chest pain (1%), myocardial injury (1%) and pericardial effusion (1%) were also recorded. […] On the contrary, CHD patients from the clinically suspected COVID-19 group presented no severe symptoms or complications. […] Despite previous reports pointing to a higher case-fatality rate among patients with cardiovascular co-morbidities, we observed a mild COVID-19 clinical course in our cohort of CHD patients. | 2020-06-11 |
| 32521706 | Clinical samples collected in coronavirus disease 19 (COVID-19), patients are commonly manipulated in biosafety level 2 laboratories for molecular diagnostic purposes. […] SARS-CoV-2 cell-culture supernatant and nasopharyngeal samples (virus-spiked samples and clinical samples collected in COVID-19 patients) were used to measure the reduction of infectivity after 10 minute contact with lysis buffer containing various detergents and chaotropic agents. | 2020-06-17 |
| 32521726 | The clinical protocol applied at the Department of Oral Maxillofacial and Surgery, such as at the Department of Radiology, Hospital University Münster, is described. | 2020-06-11 |
| 32521760 | For these reasons, we analyzed the possible role of non-pharmacological substances such as supplements, probiotics, and nutraceuticals in reducing the risk of Sars-CoV-2 infection or mitigating the symptoms of COVID-19. […] However, there are no specific data available, and rigorous clinical trials should be conducted to confirm the putative benefits of diet supplementation, probiotics, and nutraceuticals in the current pandemic. | 2020-06-15 |
| 32521953 | The clinical presentations and auxiliary examinations of the elderly patients with COVID-19 are atypical, due to the physiological ageing deterioration and basal pathological state. […] We focused on the clinical characteristics and key points for better treatment and prevention of COVID-19 in the elderly. […] (1) For diagnosis, atypical clinical presentation of COVID-19 in the elderly should be emphasized, which may be complicated by underlying disease. | 2020-06-11 |
| 32521987 | The content includes exploring diversified online teaching models for undergraduate surgery courses and clinical practice, carrying out online graduate education and dissertation plans, and strengthening comprehensive education of medical humanity combined with knowledge of COVID-19 prevention. | 2020-06-15 |
| 32522067 | Still, much information is not known, including origin of the disease, complete genomic characterization, mechanism of transmission dynamics, extent of spread, possible genetic predisposition, clinical and biological diagnosis, complete details of disease-induced pathogenicity, and possible therapeutic options. […] Although several known drugs are already under clinical evaluation with many in repositioning strategies, much attention has been paid to the aminoquinoline derivates, chloroquine (CQ) and hydroxychloroquine (HCQ). | 2020-06-24 |
| 32522074 | Recent studies have updated the epidemiologic and clinical characteristics of COVID-19 continuously. | 2020-06-22 |
| 32522191 | The purpose of this study is to report the clinical features and outcomes of Black/African American (AA) and Latino Hispanic patients with Coronavirus disease 2019 (COVID-19) hospitalized in an inter-city hospital in the state of New Jersey. […] Most common symptoms at initial presentation were dyspnea 39% (n = 162) followed by cough 38%(n = 156) and fever 34% (n = 143). | 2020-06-17 |
| 32522223 | In particular, we believe that the main road to elaborate meaningful scientific evidence is represented by the collection of all the data on COVID-19 and cancer comorbidity that are and will become available in cancer centers, coupled with the design of large clinical studies. | 2020-06-22 |
| 32522278 | In total, 2665 patients with complete clinical outcomes were analyzed. […] Furthermore, the clinical outcomes of patients with hematological malignancies were worse, with a mortality rate twice that of patients with solid tumors (50% vs. | 2020-06-26 |
| 32522282 | The study protocol has been reported in accordance with the Standard Protocol Items: Recommendations for Clinical Interventional Trials (SPIRIT) guidelines (Additional file 2). | 2020-06-17 |
| 32522306 | We report three cases of adult patients with similar underlying disease with completely different clinical severity at the time of COVID-19 infection. […] The patient with the most severe clinical course was obese and diabetic, suggesting that COVID-19 mortality and morbidity in Adult congenital heart disease patients might be independent of anatomic complexity. | 2020-06-24 |
| 32522307 | In this article, we explain the symptoms and course of the disease and the treatment for an adult patient with CHD who has been infected with novel nCoV-19. | 2020-06-25 |
| 32522362 | The COVID-19 pandemic has kicked off a global race to launch clinical trials of experimental vaccines and treatments for the coronavirus. […] Worldwide, as resources are directed toward accelerating the research into unravelling the mechanism of COVID-19 pathophysiology, concerns have been raised regarding the future of clinical research in United Kingdom and elsewhere during the current pandemic. […] However, the real immediate impact of these restrictions due to lock-down is most acutely felt by scientists working on non-COVID-19 biomedical research bench and clinical researchers whose drug trials have to be delayed, suspended or ceased. | 2020-06-13 |
| 32522407 | " 3) “If you had a remote service provision with a mental health professional (e.g. by telephone or video technology), please share your thoughts and any suggestions with us” 4) “Please share any other items that you think are important about ADHD symptoms of your child and the lockdown situation”. […] However, optimal lockdown life conditions seemed to compensate for the impact of ADHD symptoms (e.g. sufficient space at home, presence of a garden). […] The lockdown situation seems to have raised parents’ awareness of the role of inattention and ADHD symptoms in their children’s learning difficulties. | 2020-06-13 |
| 32522513 | Priority for in-person appointments should be given to patients with sexually-transmitted infection symptoms, particularly if at risk for complications, while also offering expedited partner therapy. | 2020-06-11 |
| 32522574 | A very recent epidemiological study provides preliminary evidence that living in habitats located at 2500 m above sea level (masl) might protect from the development of severe respiratory symptoms following infection with the novel SARS-CoV-2 virus. […] This article compares the symptoms of acute mountain sickness (AMS) with those of SARS-CoV-2 infection and explores overlapping patho-physiological mechanisms of the respiratory system including impaired oxygen transport, pulmonary gas exchange and brainstem circuits controlling respiration. […] Finally, since erythropoietin (EPO) is an effective prophylactic treatment for AMS, this article reviews the potential benefits of implementing FDA-approved erythropoietin-based (EPO) drug therapies to counteract a variety of acute respiratory and non-respiratory (e.g. excessive inflammation of vascular beds) symptoms of SARS-CoV-2 infection. | 2020-06-21 |
| 32522597 | We report here on four consecutive outpatients with clinical characteristics (CDC case definition) of and/or laboratory-confirmed COVID-19 who were treated with high dose zinc salt oral lozenges. […] All four patients experienced significant improvement in objective and symptomatic disease measures after one day of high dose therapy suggesting that zinc therapy was playing a role in clinical recovery. | 2020-06-11 |
| 32522632 | Its rapid spread and severe clinical presentation influences patient management in all specialties including thoracic surgery. | 2020-06-11 |
| 32522666 | Statistical surveys of COVID-19 patients indicate, against all common logic, that people who smoke are less prone to the infection and/or exhibit less severe respiratory symptoms than non-smokers. | 2020-06-27 |
| 32522674 | Several improvements have been made, including discovery of the clinical efficacy of chloroquine (CQ) in patients with COVID-19, but effective treatment protocols remain elusive. […] This review discusses lysosomotropic and lysosome targeting drugs that are already in clinical use and are characterized by good safety profiles, low cost and wide availability. […] Some of these drugs -particularly azithromycin and other macrolides, indomethacin and some other non-steroidal anti-inflammatory drugs, proton pump inhibitors and fluoxetine - could provide additional therapeutic benefits in addition to the potential antiviral effect that is still to be confirmed by well-controlled clinical trials. […] As some of these drugs have probably been used empirically in the treatment of COVID-19, it is hoped that colleagues worldwide will publish patient data to enable evaluation of the potential efficacy of these agents in the clinical context, and rapid implementation in therapeutic protocols if they are shown to have a beneficial effect on clinical outcome. | 2020-06-22 |
| 32522737 | Covid-19 related symptoms (fever, cough, and dyspnoea) and evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, defined as a positive test for virus specific nucleic acids in nasopharyngeal swabs, or a positive test for IgM or IgG antibodies in the serum samples. […] During the deployment period in Wuhan, none of the study participants reported covid-19 related symptoms. | 2020-06-19 |
| 32522754 | A rapid recovery of respiratory and general symptoms was observed after 1 week of treatment with lopinavir/ritonavir plus hydroxychloroquine and broad-spectrum antibiotics (piperacillin-tazobactam plus teicoplanin). […] No GI symptoms were reported during hospitalisation, but a lung contrast-enhancement CT (CE-CT) excluding thromboembolism showed, as collateral finding, intraperitoneal free bubbles not present on a previous CT examination; the subsequent abdominal CE-CT described pneumatosis intestinalis (PI) involving the caecum and the right colon. […] We hypothesise a multifactorial aetiopathogenesis for PI, with a possible role of the bowel wall damage and microbiota impairment due to SARS-CoV-2 infection, and we suggest a conservative management in the absence of symptoms. | 2020-06-23 |
| 32522814 | However, there is a limit where the hospitals may run out of resources to provide critical care, which is heavily dependent on trained staff, just-in-time supply chains for clinical consumables and drugs and advanced equipment. […] In the first (good) phase, we can still do clinical prioritisation and decision-making as usual, based on the need for intensive care and prognostication: what are the odds for a good result with regard to survival and quality of life. | 2020-06-24 |
| 32522844 | Early clinical experiences have demonstrated the wide spectrum of SARS-CoV-2 presentations, including various reports of atypical presentations of COVID-19 and possible mimic conditions.This article summarises the current evidence surrounding atypical presentations of COVID-19 including neurological, cardiovascular, gastrointestinal, otorhinolaryngology and geriatric features. […] The dual-process model of clinical reasoning is used to analyse the thought processes used to make a diagnosis of COVID-19, including consideration of the variety of differential diagnoses.While SARS-CoV-2 is likely to remain on the differential diagnostic list for a plethora of presentations for the foreseeable future, clinicians should be cautious of ignoring other potential diagnoses due to availability bias. | 2020-06-25 |
| 32522846 | ARDS is a clinical high-mortality disease which is probably due to the excessive activation of RAS caused by 2019-nCoV infection, and ACE2 has a protective effect on ARDS caused by COVID-19. | 2020-06-25 |
| 32523139 | Although the clinical manifestations of COVID-19 are respiratory symptoms, some patients also have cardiological symptoms. […] HF is the main chronic cardiovascular disease and patients in this group are the most vulnerable for the development of more serious clinical symptoms after suffering the infection, and to a greater extent cases with advanced HF3. […] This situation has made the National Association of Cardiologists of Mexico (ANCAM) and the Mexican Society of Cardiology (SMC) together with their respective chapters, have prepared the following recommendations for medical personnel, who participate in the care of this special group of patients in the different clinical settings, who suffer or not, of COVID-19. | 2020-06-23 |
| 32523141 | Chronic lack of control of the disease is associated with increased susceptibility to infections, which generally have few symptoms, but hyperglycemia is generally magnified, which worsens the course of infections. | 2020-06-23 |
| 32523142 | The SARS-CoV-2 infection has as a clinical manifestation the disease known as COVID-19. […] Despite the large amount of information that has been developed in recent weeks, it has been estimated that this disease can have up to 72% underdiagnosis, which requires clinical tools that are simple, easily accessible, and increase the detection of cases in a feasible way and that yield information with prognostic value. | 2020-06-23 |
| 32523143 | Based on the recommendations issued by the Ministry of Health, the clinical evidence and the resources available in the health institutions, the disease prevention measures have been initiated and maintained both in the community and in the health institutions. | 2020-06-23 |
| 32523150 | However, time has not been enough to properly evaluate their clinical effectiveness. | 2020-06-23 |
| 32523258 | Access to diagnostic tests, treatment facilities with the need to use clinical and prediction tools to guide management Telemedicine has an evolving role. […] A clinical decision along with use of clinical prediction tools for osteoporosis should be used to direct treatment. | 2020-06-12 |
| 32523681 | There is no clinical evidence that SMT improves human immunity. | 2020-06-23 |
| 32523870 | We describe the patient’s clinical course, from mild symptoms at the time of illness onset to symptoms of severe pneumonia as the illness progressed. […] We provide important information regarding our clinical experience for further understanding of management discrepancies, as treatment with extracorporeal membrane oxygenation or pharmacotherapy (e.g., antivirals, immunomodulators, and glucocorticoids) is often dependent on the severity of symptoms. | 2020-06-12 |
| 32523872 | However, it can present with other rare symptoms. […] As this disease is a new disease, the full picture of the disease presentation is not yet clear, and it might present with symptoms and signs of other common diseases. […] Here, we report a 40 year old female who presented with acute onset nausea, vomiting, loss of appetite and vague abdominal pain as a clinical picture of appendicitis, but her CT abdomen image showed normal appendix, bilateral patchy peripheral lung basal consolidation, and ground-glass attenuation, so she was tested for coronavirus disease-19, which was positive. | 2020-06-16 |
| 32523922 | A good clinical and biological response was achieved in all patients leading to hospital discharge. | 2020-06-12 |
| 32523923 | We hope our data provide additional insight into the diagnosis and therapeutic options for managing this infection.LEARNING POINTS: Laboratory findings of drained pericardial fluid in a patient with COVID-19 are presented.The clinical presentation of pericardial involvement in COVID-19 infection and the role of echocardiography in diagnosis and management are described. | 2020-06-12 |
| 32523925 | Coronavirus disease 2019 (COVID-19) is a multisystemic condition caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with manifestations ranging from mild upper respiratory symptoms to cytokine storm causing acute respiratory distress syndrome. | 2020-06-12 |
| 32523926 | We describe three cases of TTS in COVID-19-positive patients with different clinical presentations and outcomes. | 2020-06-12 |
| 32523928 | The diagnosis of pulmonary embolism is challenging in COVID-19 patients since symptoms, signs and high D-dimer blood levels might be similar in both diseases.An increase in D-dimer blood levels and a decrease in C-reactive protein blood levels over time may be used as a novel method to predict pulmonary embolism in COVID-19 patients. | 2020-06-12 |
| 32523930 | Tocilizumab (TCZ), an interleukin-6 (IL-6) inhibitor, may ameliorate the CRS associated with severe COVID-19 and thus improve clinical outcomes. | 2020-06-12 |
| 32523932 | Her admission symptoms were sensory-motor aphasia and severe right limb paresis with an NIHSS score of 24. | 2020-06-12 |
| 32523933 | We describe the case of a young female patient admitted to our emergency department during the Italian COVID-19 epidemic, for fever and dry cough associated with symptoms of gastric reflux over the previous 5 days. | 2020-06-12 |
| 32523979 | We aimed to evaluate the impact of EPPE on colonoscopy performance when compared to standard PPE (SPPE). Patients and methods A review of electronic medical records and endoscopy reports of consecutive patients who underwent colonoscopy during two similar one-month time periods (in 2019 and during the COVID-19 pandemic in 2020) was performed. […] Patient clinical data and procedure-related information were captured and analyzed. | 2020-06-12 |
| 32524194 | Of presentations in VC 70% were related to the symptoms of the anterior eye segment. | 2020-06-13 |
| 32524220 | To investigate the association of chest CT findings with mortality in clinical management of older patients. | 2020-06-13 |
| 32524227 | Fourteen HCW (21%) showed clinical symptoms compatible with a SARS-CoV-2 infection: cough (n = 4), sore throat (n = 3), nasal congestion (n = 3), dyspnea (n = 2), fever (n = 1), headache and myalgia (n = 1). | 2020-06-13 |
| 32524516 | In this study, we report the clinical and laboratory results of 57 patients with confirmed COVID-19 pneumonia and 46 patients with confirmed community-acquired bacterial pneumonia (CAP). […] After treatments, D-dimer levels decreased which was synchronous with hsCRP levels in patients with good clinical prognosis, but there were still some patients with anomalous increasing D-dimer levels after therapy. | 2020-06-13 |
| 32524537 | However, some cases exhibit other features including Central Nervous System symptoms. […] In the older adult, COVID-19 may present with atypical symptoms, including delirium and its complications. | 2020-06-13 |
| 32524611 | We aim to investigate the clinical characteristics of COVID-19 children with different severities and allergic status. […] Data extracted from the electronical medical records, including demographics, clinical manifestations, comorbidities, laboratory and immunological results and radiological images of 182 hospitalized COVID-19 children were summarized and analyzed. […] Fever (43.4%) and dry cough (44.5%) were common symptoms, and gastrointestinal manifestations accounted for 11.0%, including diarrhea, abdominal discomfort and vomiting. […] Compared to children without pneumonia(manifested as asymptomatic and acute upper respiratory infection), children with pneumonia were associated with higher percentages of the comorbidity history, symptoms of fever and cough, and increased levels of serum procalcitonin, alkaline phosphatase and serum interleukins (IL)-2, IL-4, IL-6, IL-10 and TNF-α.There were no differences of treatments, duration of hospitalization, time from first positive to first negative nucleic acid testing and outcomes between children with mild pneumonia and without pneumonia. […] Demographics and clinical features were not significantly different between allergic and non-allergic groups. […] Pediatric COVID-19 patients tended to have a mild clinical course. […] There was no difference between allergic and non-allergic COVID-19 children in disease incidence, clinical features, laboratory and immunological findings. | 2020-06-23 |
| 32524663 | The first two cases presented did not have laboratory confirmation of COVID-19 infection, but the authors reported that these patients had compatible signs and symptoms. | 2020-06-23 |
| 32524707 | Aim of this study is to determine the prevalence and severity of these symptoms among laboratory-confirmed SARS-CoV-2 patients. […] They were first symptoms in 31 (8,7%) patients. | 2020-06-19 |
| 32524708 | The current recommendations suggest that dental treatment of patients with suspected/confirmed coronavirus disease should be postponed for at least 14 days from the onset of symptoms (Peng et al., 2020). | 2020-06-23 |
| 32524712 | A telephone survey was used to collect the data. 42 patients presented symptoms suggestive of infection by COVID-19 and in 6 cases the disease was confirmed by RT-PCR. | 2020-06-23 |
| 32524732 | The novel Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) disease 2019 (COVID-19) seems to have a worse clinical course among infected men compared to women, thus, highlighting concerns about gender predisposition to serious prognosis. […] However, gonadal function in critically ill men is actually unknown, mainly because serum T concentration is not routinely measured in clinical practice, even more in this clinical context. | 2020-06-23 |
| 32524743 | This protocol was created utilizing the guidelines of various organizations and from the clinical experience of the authors and will continue to evolve as more is understood about SARS-CoV-2 and how it affects organ donors and transplant recipients. | 2020-06-11 |
| 32524786 | To investigate the value of initial CT quantitative analysis of ground-glass opacity (GGO), consolidation, and total lesion volume and its relationship with clinical features for assessing the severity of coronavirus disease 2019 (COVID-19). […] Clinical symptoms, laboratory data, and CT findings on admission were analyzed. […] CT quantitative parameters showed strong correlations with laboratory inflammatory markers, suggesting that CT quantitative analysis might be an effective and important method for assessing the severity of COVID-19, and may provide additional guidance for planning clinical treatment strategies. | 2020-06-19 |
| 32524792 | Data on clinical and CT features were collected and analyzed. | 2020-06-19 |
| 32524843 | In this review, we summarize the epidemiological, genetic and clinical characteristics of the virus as well as laboratory testing and treatments to understand the nature of the virus. | 2020-06-13 |
| 32524957 | A continuum of clinical features from Kawasaki-like disease to myocarditis was observed, requiring intensive care in 67% of cases. | 2020-06-18 |
| 32524962 | SARS-CoV-2 infection can present with various clinical features, among which gastrointestinal manifestations such as nausea, diarrhea, vomiting, and mild abdominal pain have been reported. […] We discuss the management course, highlight the importance of abdominal symptoms in the setting of COVID-19, and discuss the implications of this association for medical practice amid the current pandemic in both resource-rich and resource-limited settings. | 2020-06-11 |
| 32524964 | The newly discovered SARS-CoV-2 is the cause of COVID-19, including severe respiratory symptoms with an important lethality rate and high dissemination capacity. | 2020-06-11 |
| 32525005 | Recently, through its anti-inflammatory and anti-oxidant effects, PFD based clinical trial has also been launched for the treatment of coronavirus disease (COVID-19). | 2020-06-28 |
| 32525022 | Where uncertainty exists treatment should be informed by a dynamic risk assessment which may consider current COVID-19 prevalence, the person’s presentation (e.g. history of COVID-19 contact, COVID-19 symptoms), likelihood that treatment will be effective, availability of personal protective equipment (PPE) and personal risks for those providing treatment. | 2020-06-28 |
| 32525082 | Results indicate that telehealth can successfully support clinical decision making for hospice reauthorization. | 2020-06-27 |
| 32525251 | The novel coronavirus, otherwise known as COVID-19 has fast become a major health concern.1 2 It has been reported that in addition to the conventional respiratory symptoms, patients also display skin manifestations such as Urticaria and angioedema.3 Here we present a case study of an elderly man who first presented with generalised pruritic hives ranging from 1.5 to 8.0 cm in diameter on the 5th of March 2020. […] On the 5th of March 2020 the patient-reported these symptoms plus general malaise, fatigue, 37.9⁰C temperature and sore throat. | 2020-06-23 |
| 32525367 | In this context, severe forms of traumatic distress, guilt, somatization, regret, anger, and unspecific symptoms not yet included in prolonged grief disorder (PGD) criteria could emerge. […] This article (a) analyzes factors related to bereavement in the context of the COVID-19 pandemic; (b) proposes avenues for meaning-making practices to facilitate individual and collective mourning process; and (c) invites clinicians to pay attention to the traumatic characteristics of COVID-19-related deaths adopting a holistic approach of PGD clinical manifestations, as well as in evaluation and treatment of cases. | 2020-06-11 |
| 32525378 | This Commentary identifies risks that HCWs are experiencing, reviews sources of fear and stress, and describes the implementation of a three-tiered model for the provision of emotional support and mental health services for clinical and nonclinical HCWs. | 2020-06-11 |
| 32525469 | The asymptomatic carriers discussed in this study are recessive infections, that is, those who have never shown symptoms after onset of infection. | 2020-06-26 |
| 32525548 | To investigate the prevalence, causes, and clinical implications of hypokalemia, including its possible association with treatment outcomes, among patients with COVID-19. […] The clinical features, therapy, and outcomes were compared between the 3 groups. […] Their epidemiological and clinical features were collected. | 2020-06-17 |
| 32525549 | Coronavirus disease 2019 (COVID-19) is a global pandemic and can involve the gastrointestinal (GI) tract, including symptoms like diarrhea and shedding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in feces. […] To provide a pooled estimate of GI symptoms, liver enzyme levels outside reference ranges, and fecal tests positive for SARS-CoV-2 among patients with COVID-19. […] Search terms included “COVID-19,” “SARS-Cov-2,” and/or “novel coronavirus.” Eligible studies were those including patients with SARS-CoV-2 infection who reported GI symptoms. […] Data on patients with GI symptoms (ie, diarrhea, nausea, or vomiting), liver enzyme level changes, and fecal shedding of virus were extracted. […] These findings suggest that that 12% of patients with COVID-19 will manifest GI symptoms; however, SAR-CoV-2 shedding was observed in 40.5% of patients with confirmed SARS-CoV-2 infection. | 2020-06-17 |
| 32525600 | The dynamics, such as transmission, spatial epidemiology, and clinical course of Coronavirus Disease-2019 (COVID-19) have emerged as the most intriguing features and remain incompletely understood. | 2020-06-19 |
| 32525650 | Because this is an unexploited resource for potential antivirals, we believe that cockroaches offer a unique source for novel bioactive molecule(s) to counter COVID-19 with huge clinical impact worldwide. | 2020-06-11 |
| 32525695 | Modifications to standard clinical practice in tracheostomy are often required. | 2020-06-16 |
| 32525707 | In early March 2020, an outbreak of the coronavirus disease 2019 (COVID-19) in New York City exerted sudden and extreme pressures on emergency medical services and quickly changed public health policy and clinical guidance. […] Hotline clinicians provided New Yorkers with clinical assessment and guidance, registered them for home symptom monitoring, connected them to social services, and provided a source of up-to-date answers to COVID-19 questions. […] Future consideration should be given to promoting easy access to clinician hotlines by disadvantaged communities early in a public health crisis as well as evaluating the impact of clinician hotlines on clinical outcomes. [Editor’s Note: This Fast Track Ahead Of Print article is the accepted version of the manuscript. | 2020-06-11 |
| 32525726 | Clinical, surgical, and safety implications are discussed. | 2020-06-11 |
| 32525825 | Given the important contribution of frailty, use of the Clinical Frailty Scale (CFS) is discussed as a readily implementable measure, as are lessons learned from the study of frailty in relation to influenza. | 2020-06-22 |
| 32525828 | The demographic, epidemiological, clinical, laboratory parameters were obtained from each patient. […] The most common symptoms at the onset of illness were fever (96.4%), cough (67.9%), and chilly (28.6%), and 75.0% patients had two or more symptoms. […] Among the 28 admitted patients, 24 were discharged as of February 26, 2020, with an average hospital stay of 14.96 (±4.27) days, which was not significantly associated with the interval between the onset of symptoms and admission. | 2020-06-22 |
| 32525829 | We describe the clinical manifestations, disease progression, and treatment of wife and husband. | 2020-06-22 |
| 32525850 | The outbreak was characterized by widespread transmission with relatively mild symptoms and asymptomatic infection among this sample of mostly young, healthy adults with close, congregate exposures. | 2020-06-12 |
| 32525856 | Health messages that reinforce the importance of immediately seeking care for symptoms of serious conditions, such as myocardial infarction, are needed. | 2020-06-12 |
| 32525973 | The potential for endocrine care via telemedicine has been recognized since the early 2000s when clinical outcome data demonstrated improvements in glycemic control with telemedicine. […] The widespread use of telemedicine during the COVID-19 pandemic has pushed telemedicine beyond diabetes care and into clinical areas with a paucity of published data. […] Clinical and economic outcomes of telemedicine care of thyrotoxicosis should be studied so that standards of care for endocrine telemedicine can be established. | 2020-06-11 |
| 32526060 | As the clinical evidence is still limited, it makes a sense to critically analyze the spectrum of neurologic involvement caused by SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV), which were causal for epidemics in 2003 and 2012, respectively. | 2020-06-23 |
| 32526061 | Some clinical trials are testing biological drugs to limit the immune system dysregulation, “cytokines storm”, that causes the systemic complications of COVID-19. […] Numerous clinical and experimental studies have revealed a role for the nitric oxide (NO)-cyclic GMP-phosphodiesterase type 5 (PDE5) pathway in modulating low-grade inflammation in patients with metabolic diseases, offering cardiovascular protection. […] We performed a systematic review of all evidence documenting any involvement of the NO-cGMP-PDE5 axis in the pathophysiology of COVID-19, presenting the ongoing clinical trials aimed at modulating this axis, including our own “silDEnafil administration in DiAbetic and dysmetaboLic patients with COVID-19 (DEDALO trial)”. | 2020-06-23 |
| 32526077 | The COVID-19 pandemic has rapidly challenged the pharmaceutical industry to implement remote clinical trials. | 2020-06-23 |
| 32526079 | Since there are no effective preventive or curative therapies currently, MSC therapy (MSCT) has emerged as a possible candidate despite the lack of preclinical data of MSCs for COVID-19. […] Interestingly, MSCT preclinical data specifically on immune/inflammatory disorders of the lungs were among the earliest to be reported in 2003, with the first clinical use of MSCT for graft-vs-host disease reported in 2004. […] Since these first reports, preclinical data showing beneficial effects of MSC immunomodulation have accumulated substantially, and as a consequence, over a third of MSCT clinical trials now target immune/inflammatory diseases. […] There is much preclinical evidence for MSCT in noninfectious-including chronic obstructive pulmonary disease, asthma, and idiopathic pulmonary fibrosis-as well as infectious bacterial immune/inflammatory lung disorders, with data generally demonstrating therapeutic effects; however, for infectious viral pulmonary conditions, the preclinical evidence is more scarce with some inconsistent outcomes. […] In this article, we review the mechanistic evidence for clinical use of MSCs in pulmonary immune/inflammatory disorders, and survey the ongoing clinical trials-including for COVID-19-of MSCT for these diseases, with some perspectives and comment on MSCT for COVID-19. | 2020-06-19 |
| 32526083 | Abnormality in liver function tests (LFTs) has been commonly observed in patients with COVID-19, but there is controversy on its clinical significance. […] The aim of this study was to assess the prevalence, the characteristics and the clinical impact of abnormal LFTs in hospitalized, non-critically ill patients with COVID-19. | 2020-06-23 |
| 32526093 | The cases are still rising at an exponential rate and manifold trials are on to test different agents with the hope for potential limitation of spread and control of symptoms. | 2020-06-19 |
| 32526193 | COVID-19 is characterised by respiratory symptoms, which deteriorate into respiratory failure in a substantial proportion of cases, requiring intensive care in up to a third of patients admitted to hospital. […] Analysis of the pathological features in the lung tissues of patients who have died with COVID-19 could help us to understand the disease pathogenesis and clinical outcomes. | 2020-06-13 |
| 32526206 | The mode of acquisition and causes for the variable clinical spectrum of coronavirus disease 2019 (COVID-19) remain unknown. | 2020-06-20 |
| 32526208 | Nucleotide analog inhibitors, including broad-spectrum remdesivir and favipiravir, have shown promise in in vitro assays and some clinical studies for COVID-19 treatment, this despite an incomplete mechanistic understanding of the viral RNA-dependent RNA polymerase nsp12 drug interactions. | 2020-06-13 |
| 32526224 | Besides the comprehensive treatments for COVID-19, as a cardiologist, we should also remain vigilant about the cardiac injuries, especially those with severe emergent cardiovascular symptoms. | 2020-06-27 |
| 32526252 | This study aimed at evaluating the impact of COVID-19 on the clinical outcome of these patients. […] Clinical and biochemical data at COVID-19 and at the last outpatient visit were obtained through review of medical records. | 2020-06-13 |
| 32526265 | As for clinical exposure, 92 (82.1%) trainees responded that their clinical exposure is affected too. […] The changes in the surgical residency programs amidst the pandemic has reduced the working hours, hands-on and clinical exposure of the surgical residents. | 2020-06-26 |
| 32526275 | Clinical characteristics and baseline laboratory findings were collected. | 2020-06-28 |
| 32526365 | We present the clinical outcomes of these three COVID-19 patients, who underwent an intra-cerebral biopsy in our department during April of 2020. | 2020-06-26 |
| 32526378 | To explore the clinical, operational, and financial feasibility of a home telehealth (HTH) program in a pediatric allergy and immunology clinic. | 2020-06-12 |
| 32526460 | There is a pressing need for evidence-based interventions to address the devastating clinical and public health effects of the Coronavirus disease 2019 (COVID-19) pandemic. […] To describe the characteristics of the currently registered clinical trials related to COVID-19. […] We searched the World Health Organization (WHO)’s International Clinical Trials Registry Platform (ICTRP) on May 15, 2020. […] The majority of trials were initially registered with ClinicalTrials.gov (n= 703; 53.7%) and the Chinese Clinical Trial Registry (ChiCTR) (n= 291; 22.2%). | 2020-06-13 |
| 32526507 | Although there are ongoing clinical trials to test the efficacy of hydroxychloroquine for prophylaxis, there has not been any proposal to test the efficacy of IFN α-2b together with hydroxychloroquine to increase protection against COVID-19. | 2020-06-26 |
| 32526541 | Pertinent clinical information related to pediatric otolaryngology was reviewed from journals, Texas Medical Board guidelines as well as institutional guidelines. […] Safety measures and clinical work-flow protocols were developed to protect patients, families, and staff. […] It is imperative that a modification in clinical workflow is created to minimize the risk of exposure to providers and staff while continuing to provide care to patients. | 2020-06-26 |
| 32526545 | Although a large proportion of infected individuals develop only mild symptoms or are asymptomatic, the spectrum of the disease among others has been widely variable in severity. […] Furthermore, we discuss the possible underlying mechanisms of hypercoagulability and highlight the possibility of underdiagnosing pulmonary embolism in the setting of overlapping symptoms, decreased utilization of imaging secondary to associated risks, and increased turnover times. | 2020-06-26 |
| 32526560 | Details on the onset date of clinical symptoms, throat swab conversion, and course of disease were collected from medical records retrospectively. […] The longest throat swab conversion time was 37 days, and the estimated course of disease from symptoms to first conversion of throat swab was 59 days. | 2020-06-23 |
| 32526698 | The impact of the therapeutic agent on the immune response against the future SARS-CoV-2 vaccine should also be considered in the clinical decision-making. | 2020-06-26 |
| 32526746 | We suggest prevention of clinical infection and control during administration of RRT in the acute phase of COVID-19 patients with AKI or multiple organ failure. | 2020-06-11 |
| 32526759 | In this cross-sectional controlled cohort study, 500 patients who presented with symptoms of a common cold to a corona testing center and fulfilled corona testing criteria completed a standardized diagnostic questionnaire which included the patients’ main symptoms, time course, and an additional self-assessment of the patients’ current smell, taste function, and nasal breathing compared to the level before the onset of symptoms. | 2020-06-11 |
| 32526763 | These activities, together with its anticoagulant action, could explain the ability of heparin to ameliorate COVID-19 clinical course. | 2020-06-11 |
| 32527056 | Although most cases have mild symptoms, there is some progression to viral pneumonia and multi-organ failure and death. | 2020-06-16 |
| 32527136 | Usually, after viral pneumonia were clinical cured, the pulmonary lesions of majority patients will gradually be absorbed to complete dissipation, very few severe patients may retain pulmonary interstitial inflammation and fibrosis (1-3). […] In this case, we described one unique COVID-19 patient, the symptoms were: dry cough, fatigue, poor appetite and subjective fever, moreover, the patient was a non-smoker, had no pulmonary bullous, no history of tuberculosis, and also no hypertension or diabetes. […] After two weeks of treatment and observation, the patient was clinical cured and discharged. […] In hospital, the patient showed no symptoms of infection for another 14 days, and the pulmonary cavity remain unchanged. | 2020-06-12 |
| 32527141 | Covid-19 is defined by an association of multiple symptoms, including frequently reported olfactory and gustatory disorders. | 2020-06-12 |
| 32527257 | Therefore, T2DM patients frequently report respiratory symptoms and are at increased risk of several pulmonary diseases. | 2020-06-25 |
| 32527327 | Her clinical course was notable for high fevers, night sweats, productive cough, transient leukopenia, lymphopenia, thrombocytopenia, and transaminitis. […] This case highlights our patient’s clinical course, including diagnostic work-up, medical management, and challenges in defining non-infectivity in a relatively unknown disease. | 2020-06-23 |
| 32527340 | To investigate the clinical treatment and assess the knowledge and use of the coronavirus disease 2019 (COVID-19) treatment plan issued by the nation. […] Further practical training is needed to make clinicians more aware of the disease, and more evidence-based evidence is needed to guide clinical treatment. | 2020-06-16 |
| 32527341 | To analyze the clinical characteristics of critical patients with coronavirus disease 2019 (COVID-19), build an early warning model for severe/critical type, and aim at providing reference for the prediction of severe/critical COVID-19. […] The clinical data of COVID-19 patients treated in the Second People’ Hospital of Fuyang City from January 20th to February 18th in 2020 were retrospective analyzed, including the demographic and epidemiological date, vital signs and hematology indexes, etc. on admission. | 2020-06-16 |
| 32527342 | A retrospective cohort study was performed to examine the basic data, clinical characteristics and prognosis of patients with COVID-19 in Zhongnan Hospital of Wuhan University and Wuhan Fourth Hospital from January 1st to February 1st in 2020. | 2020-06-16 |
| 32527343 | To investigate the clinical characteristics of gastrointestinal symptoms in patients with coronavirus disease 2019 (COVID-19) during the whole disease process, and provide reference for etiological diagnosis and treatment. […] The clinical data of patients with COVID-19 admitted in the Infectious Diseases Branch of the First Affiliated Hospital of University of Science and Technology of China from January 22nd, 2020 to March 8th, 2020 were analyzed retrospectively. […] According to whether there were gastrointestinal symptoms (poor appetite, nausea/vomiting and diarrhea), all patients were divided into gastrointestinal symptom group and asymptomatic group. […] The characteristics of gastrointestinal symptoms, such as poor appetite, nausea, vomiting and diarrhea were counted and analyzed, and the correlation between gastrointestinal symptoms and gender, age, basic diseases, disease severity, laboratory examination and drug treatment were analyzed. […] Among them, 5 cases, 1 case and 4 cases respectively preformed poor appetite, nausea/vomiting and diarrhea before admission, while the others experienced gastrointestinal symptoms within 48 hours after admission. […] The patients with poor appetite were older than those without symptoms (years old: 48.2±17.6 vs. […] 3.12 (2.77, 4.90)]; at the same time, more traditional Chinese medicine was used in the patients with gastrointestinal symptoms [65.1% (28/43) vs. […] In addition, 14 cases of 18 patients with cardiovascular diseases presented with poor appetite, 7 patients had nausea and vomiting symptoms. […] The gastrointestinal symptoms in patients with COVID-19 are common. […] Whether it is caused by the virus or related drugs, diet and mental conditions, clinicians should analyze the causes of these symptoms timely, and then provide a better treatment for patients with COVID-19. | 2020-06-16 |
| 32527344 | The routine blood test and biochemical results of two groups were observed, and the efficacy evaluation was performed by monitoring the time for significant improvement of symptoms, negative conversion time of throat swab virus nucleic acid, lung lesion absorption time, adverse drug reactions and the length of hospital stay of the two groups. […] In artesunate treatment group, the time for significant improvement of symptoms (days: 3.33±1.91 vs. | 2020-06-16 |
| 32527345 | To analyze the epidemiological characteristics and clinical features of the patients with coronavirus disease 2019 (COVID-19), so as to provide basis for clinical diagnosis. […] The epidemiology, clinical symptoms, laboratory and radiologic data of 23 patients with COVID-19 admitted to the Fifth People’s Hospital of Xinyang City from January 22nd to January 29th, 2020 were retrospectively analyzed. […] Clinical symptoms included fever (100%), cough (69.6%), expectoration (43.5%), myalgia (26.1%), headache (17.4%) and dyspnea (17.4%), and the less common symptom was diarrhea (4.3%). […] Epidemic history of contact, fever, pneumonia signs of chest CT, normal or decreased count of leukocyte and lymphopenia are the clinical basis for diagnosis of COVID-19. | 2020-06-16 |
| 32527347 | Clinical data of patients with severe H1N1 influenza virus pneumonia implemented by ECMO in the First Affiliated Hospital of Wannan Medical College from October 2018 to December 2019 were retrospective analyzed, including general information, ECMO transport distance, time, clinical parameters before and after ECMO, including the patients’ oxygenation index (PaO2/FiO2), respiratory rate (RR), pulse blood oxygen saturation (SpO2), arterial blood carbon dioxide partial pressure (PaCO2), and pH value, various complications during transport, mechanical ventilation time, patients’ prognosis and other indicators. | 2020-06-16 |
| 32527348 | Clinical studies of convalescent plasma and immunoglobulin in the treatment of SARS were collected from a variety of databases such as PubMed, Cochrane Library, Web of Science, Embase, CNKI, VIP, Wanfang, and CBM from November 2002 to March 2020. […] Two researchers independently screened the literature, extracted the data, and assessed the risk of bias based on the national institute for health and clinical excellence case series quality scale, and systematically evaluated the results. […] A total of 10 clinical studies, including 212 patients, were eventually included. […] The treatment of convalescent plasma and immunoglobulin could both improve the symptoms and reduce the mortality (12 died), and most SARS patients got better, while 11 SARS patients who did not receive the above therapies died. […] Convalescent plasma and immunoglobulin were effective on relieving symptoms of SARS patients. | 2020-06-16 |
| 32527471 | The clinical picture of SARS-CoV-2 infection (COVID-19) is characterized in its more severe form, by an acute respiratory failure which can worsen to pneumonia and acute respiratory distress syndrome (ARDS) and get complicated with thrombotic events and heart dysfunction. | 2020-06-14 |
| 32527573 | Youth with HIV (YHIV) face many psychosocial and structural challenges resulting in poor clinical outcomes including lower rates of medication adherence and higher rates of uncontrolled HIV. […] As most of our YHIV are from marginalized communities (racial/ethnic, sexual, and gender minorities) with existing health and social inequities that impede successful clinical outcomes and increase HIV disparities, there was heightened concern that COVID-19 would exacerbate these inequities and amplify the known HIV disparities. | 2020-06-12 |
| 32527576 | Patients’ characteristics and clinical information were obtained from electronic medical and nursing records. | 2020-06-26 |
| 32527624 | We searched PubMed and Scopus for eligible studies, including clinical and preclinical studies assessing the presence of any virus in the surgical smoke from any surgical procedure or experimental model. […] Other clinical studies suggested a consistent risk of transmission for human papillomavirus (HPV) in the surgical treatments of HPV-related disease (mainly genital warts, laryngeal papillomas, or cutaneous lesions). […] Preclinical studies showed conflicting results, but HPV was shown to have a high risk of transmission. […] Specific clinical studies are needed to understand the effective presence of the virus in the surgical smoke of different surgical procedures and its concentration. | 2020-06-15 |
| 32527675 | We assessed the rate and clinical presentation of COVID-19, and adherence to therapy in a large cohort of patients with ARD followed-up in a tertiary University-Hospital in Northeast Italy. | 2020-06-12 |
| 32527699 | Below, we provide a review of pre-clinical and clinical studies that link coronavirus to the RAAS. | 2020-06-14 |
| 32527713 | Based on these, we proposed the new formulation called as “SNACK-V” CONCLUSION: Based on further experiments and clinical trials, these formulations could be used for effective treatment of COVID-19. | 2020-06-25 |
| 32527756 | A number of symptoms occur in these patients due to the involvement of various endocrine glands. […] These clinical presentations went largely unnoticed during the first outbreak of severe acute respiratory syndrome (SARS) in 2002-2003. | 2020-06-25 |
| 32527790 | The main aspects to be considered include decision algorithms for rationing care, training on effective symptoms management, alternative delivery methods of palliative care services such as telemedicine and finally death and bereavement support for surviving family members who are likely to be isolated from their loved one at the moment of death. | 2020-06-12 |
| 32527802 | There is an urgent need for SARS-CoV-2 serologic tests to identify all infected individuals, irrespective of clinical symptoms, to conduct surveillance and implement strategies to contain spread. […] By day 9 after the onset of symptoms, the recombinant SARS-CoV-2 RBD antigen was highly sensitive (98%) and specific (100%) for antibodies induced by SARS-CoVs. | 2020-06-26 |
| 32527842 | Analyzed variables were neurologic symptoms and acute imaging findings. […] The most frequent symptoms that motivated neuroimaging examinations were mild nonfocal neurologic symptoms, code stroke (refers to patients presenting with signs and symptoms of stroke whose hyperacute assessment and care is prioritized), focal neurologic symptoms, postsedation encephalopathy, and seizures. | 2020-06-12 |
| 32527863 | Digital crowdsourcing is a key tool in this pandemic to create and distil desperately needed clinical evidence and exchange of knowledge for patients and physicians alike. | 2020-06-12 |
| 32527925 | These findings provide a strong rationale for rethinking the pathophysiological role of IFN-λ and its possible use in the clinical practice against endemic viruses, such as influenza virus, as well as the emerging SARS-CoV-2 viral infection. | 2020-06-12 |
| 32527987 | While fever, cough, and respiratory distress are typical first symptoms, a fraction of those affected present instead with neurological symptoms suggestive of central nervous system compromise. […] Additionally, both age- and/or disease-related immune dysfunction and enhanced catecholamine release secondary to anxiety and stress may also aggravate central nervous system symptoms of severe acute respiratory syndrome coronavirus 2 infection. […] Thus, assessment of systemic inflammatory biomarkers and tight control of hemodynamic parameters upon admission are crucial to minimize mortality and morbidity in coronavirus disease 2019 patients with central nervous system symptoms suggestive of incipient stroke. | 2020-06-26 |
| 32527993 | This study will be conducted following the principles established by the protocol, the Declaration of Helsinki, and the Ethical Guidelines for Clinical Research. | 2020-06-17 |
| 32528195 | This proposal needs to be confirmed by further experimental and clinical research. | 2020-06-13 |
| 32528621 | Until now there is no real treatment of COVID-19 and many proposed drugs are under clinical trials. | 2020-06-17 |
| 32528622 | Until now there is no real treatment of COVID-19 and many proposed drugs are under clinical trials. | 2020-06-17 |
| 32528760 | However, multiple studies that highlight the clinical features, laboratory findings, and prognosis of acute myocardial injury (AMI) in COVID-19-affected individuals have been published. […] In this review, we have summarized the findings of all those studies as well as the clinical features and management of cardiac injury discussed by some case reports. | 2020-06-13 |
| 32528770 | We anticipate that, because of the high inflammatory response, other cardiovascular complications may also occur in COVID-19 patients with severe symptoms. | 2020-06-13 |
| 32528783 | Data collected from the studies have proposed that COVID-19 is not unusual in demonstrating the neurological symptoms, as it proved in the past by its sister coronaviruses such as severe acute respiratory syndrome coronavirus-1 (SARS-COV-1) and Middle Eastern respiratory syndrome coronavirus (MERS-COV). | 2020-06-13 |
| 32528785 | Clinical presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is very variable amongst patients, and the literature about unusual presentations is growing rapidly. […] This also highlights the significance of a high index of clinical suspicion for SARS-CoV-2 especially in high risk and vulnerable populations. | 2020-06-13 |
| 32528816 | Coronavirus Disease-19 (COVID-19) is a respiratory infection characterized by the main symptoms of pneumonia and fever. | 2020-06-13 |
| 32528820 | One hundred seven imported cases (75.9%) developed symptoms within 5 days before or after, entry to South Korea. | 2020-06-13 |
| 32529041 | We sought to investigate whether humans using ACEI were at increased risk of S. aureus infection, comparing them to users of Angiotensin II Receptor Blockers (ARB) with multiple control outcomes to assess the potential for residual confounding. Methods: Using the UK Clinical Practice Research Datalink linked to Hospital Episode Statistics between 1997 and 2017, we identified adults starting ACEI or ARB (as an active comparator drug). | 2020-06-14 |
| 32529358 | Data on ECG and echocardiogram were retrospectively analyzed along with demographics, clinical features and blood parameters. | 2020-06-15 |
| 32529424 | Clinical management strategies included restricted access to buildings, triage systems, telemedicine approaches, strategies for rapid treat and release, and transparent communication strategies. | 2020-06-15 |
| 32529477 | The aim of the present review was to summarize experimental data and clinical observations that linked the pathophysiology mechanisms of “inflamm-aging”, mild-grade inflammation, and cytokine storm in some elderly adults with severe COVID-19 infection. | 2020-06-15 |
| 32529516 | This case report describes the clinical characteristics of a 50-year-old woman that developed SARS-CoV-2 pneumonia and was admitted at the COVID-19 dedicated unit where she developed neurological symptoms 10 days after admission. […] Fourteen days after the start of IVIG treatment, the patient has been discharged at home with the resolution of respiratory symptoms and only minor hyporeflexia at the lower limbs, without any side effect. | 2020-06-15 |
| 32529517 | In this article, we review currently available clinical data, and mechanisms for COVID-associated coagulopathy, and propose algorithms for screening, prevention (including extended-duration prophylaxis), and treatment of these patients. | 2020-06-18 |
| 32529545 | In order to combat SARS-CoV-2, many drug and vaccine development studies at experimental and clinical levels are currently conducted worldwide. | 2020-06-15 |
| 32529575 | However, clinical research on its neurological manifestations is thus far limited. […] In this study, we aimed to systematically collect and investigate the clinical manifestations and evidence of neurological involvement in COVID-19. […] All included studies were systematically reviewed, and selected clinical data were collected for meta-analysis via random-effects. […] The meta-analysis for unspecific neurological symptoms revealed that the most common manifestations were fatigue (33.2% [23.1-43.3]), anorexia (30.0% [23.2-36.9]), dyspnea/shortness of breath (26.9% [19.2-34.6]), and malaise (26.7% [13.3-40.1]). […] The common specific neurological symptoms included olfactory (35.7-85.6%) and gustatory (33.3-88.8%) disorders, especially in mild cases. […] Emerging clinical evidence suggests neurological involvement is an important aspect of the disease. | 2020-06-15 |
| 32529595 | Despite the ridiculously large number of papers that have flooded scientific journals and preprint-hosting websites, a clear clinical picture of COVID-19 aftermath is vague at best. | 2020-06-15 |
| 32529643 | While RT-PCR of neonatal swabs was universally performed, a wide range of clinical samples was screened including vaginal secretions (22.5%), amniotic fluid (35%), breast milk (22.5%) and umbilical cord blood. | 2020-06-23 |
| 32529795 | We describe patients of different history of symptoms and time duration. | 2020-06-24 |
| 32529815 | To compare the accuracies of quantitative computed tomography (CT) parameters and semiquantitative visual score in evaluating clinical classification of severity of coronavirus disease (COVID-19). […] Demographic data, imaging characteristics, and clinical data were collected, and based on the clinical classification of severity, patients were divided into groups 1 (mild) and 2 (severe/critical). […] Correlation coefficients of the quantitative CT parameters, semiquantitative visual score, and clinical classification were calculated using Spearman’s correlation. | 2020-06-12 |
| 32529866 | This review presents the basic biology of coronaviruses, epidemiology of COVID-19, clinical presentations, investigational therapies and vaccines, infection prevention and control measures and the lessons from the present pandemic. […] Clinical trials at different phases are ongoing across different countries to expedite development of effective drugs and vaccine to overcome the pandemic. | 2020-06-12 |
| 32530131 | Assuming negative repeat RT-PCR, clear chest imaging, and lack of subsequent symptoms represent the “gold standard,” RT-PCR specificity was 0.97. | 2020-06-24 |
| 32530148 | The authors report here preliminary data on the spread of this disease within the region and on the clinical trend of the infected patients who needed to be hospitalised. | 2020-06-17 |
| 32530160 | Objective To retrospectively analyze the forensic pathological postmortem examination and clinical data of children who died of viral pneumonia in identification of cause of death cases and to discuss the clinical characteristics and pathological features of viral pneumonia in children, in order to provide reference to pathological diagnosis of viral pneumonia in children caused by 2019 novel coronavirus （2019-nCoV） infection. […] The gender, age, clinical symptoms and pathological features were comparatively analyzed. […] Conclusion The clinical symptoms of children with viral pneumonia are difficult to notice, and because the immune systems of children are not fully developed and they have poor immunity, they can easily become severely ill and even die. | 2020-06-16 |
| 32530314 | We evaluated the feasibility of multidisciplinary assessment of patients with ALS, using telememedicine during the emergency determined by the COVID-19 pandemic. Methods: All patients included in this survey had received a diagnosis of ALS according to international criteria after a complete clinical and paraclinical assessment during 2019. […] A video interaction was offered but refused by all patients because they did not feel comfortable or did not have smartphone. Results: Out of 31 clinical interviews 8 were completed directly with the patients and 23 with patients’ caregivers. […] Notably, none of the patients presented index symptoms of Covid-19 infection. Conclusion: Our study indicates that telemedicine is a valid tool to triage patients with ALS to increase practice outreach and efficiency. | 2020-06-12 |
| 32530326 | Objective: This rapid systematic review investigated audio-vestibular symptoms associated with coronavirus.Design: The protocol for the rapid review was registered in the International Prospective Register of Systematic Reviews and the review methods were developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. […] Risk of bias was assessed using the National Institute of Heath quality assessment tools.Study sample: After rejecting more than 2300 records, there were five case reports and two cross-sectional studies that met the inclusion criteria.Results: No records of audio-vestibular symptoms were reported with the earlier types of coronavirus (i.e. severe acute respiratory syndrome [SARS] and Middle East respiratory syndrome [MERS]). […] Reports of hearing loss, tinnitus, and vertigo have rarely been reported in individuals who tested positive for the SARS-CoV-2.Conclusion: Reports of audio-vestibular symptoms in confirmed COVID-19 cases are few, with mostly minor symptoms, and the studies are of poor quality. | 2020-06-12 |
| 32530367 | It observes that clinical judgment influenced by protocols, algorithms and resource constraints do not lend themselves to full identification with either of the two frameworks familiar to the NHS. | 2020-06-12 |
| 32530369 | New treatment options for patients with severe symptoms and ways of reducing transmission in the community are taken into consideration. | 2020-06-19 |
| 32530389 | Based on our research, we found that patients with COVID-19 can present with neurological symptoms that can be broadly divided into central nervous system involvement, such as headache, dizziness, altered mental state, and disorientation, and peripheral nervous system involvement, such as anosmia and hypogeusia. | 2020-06-12 |
| 32530453 | Patients older than 65 years were also matched for the Clinical Frailty Scale score. | 2020-06-12 |
| 32530490 | When evaluated on clinical samples showed a high sensitivity of 95%, specificity of our assay was 100% and clinical performance for detection of SARS-CoV-2 in comparison with other reference assays. | 2020-06-23 |
| 32530494 | Published studies describing clinical characteristics of the disease contain small cohorts from individual centers or larger series consisting of mixed series from multiple different hospitals. […] The cohort includes 297 patients with confirmed and 105 with clinical diagnosis. […] The latter group consists of cases with inconclusive nucleic acid test but meeting the criteria for clinical diagnosis. | 2020-06-23 |
| 32530507 | All patients were treated early with a short course of corticosteroids, and clinical outcomes were compared before and after corticosteroids administration. […] Early administration of short course corticosteroids improves clinical outcome of patients with severe COVID-19 pneumonia and evidence of immune hyper-reactivity. | 2020-06-23 |
| 32530509 | Decision tree analysis by combining cardiac markers with demographic and clinical features was applied to predict mortality and severity in COVID-19 patients. | 2020-06-23 |
| 32530522 | The report may have a significant impact on the clinical management and public health decision making. | 2020-06-23 |
| 32530531 | The aim of this study was to review the limited cases of COVID-19/influenza coinfection currently available in the literature, along with cases in the community of El Paso, Texas, to determine whether any patterns of clinical presentation and morbidity emerged. […] The most common presenting symptoms were fever and cough. | 2020-06-12 |
| 32530552 | The relationship between anxiety scores of children with CF and their mothers was evaluated by comparing with clinical data of children with CF. | 2020-06-26 |
| 32530597 | Many COVID-19 patients are presenting with atypical clinical features. […] Happy hypoxemia with almost normal breathing, anosmia in the absence of rhinitis or nasal obstruction, and ageusia are some of the reported atypical clinical findings. […] Based on the clinical manifestations of the disease, we are proposing a new hypothesis that SARS-CoV-2 mediated inflammation of the nucleus tractus solitarius may be the reason for happy hypoxemia in COVID-19 patients. | 2020-06-12 |
| 32530738 | Given the need to prevent the worsening of symptoms and the occurrence of medical complications in these groups, a reorganization of the stroke-care networks is necessary to reduce collateral damage caused by COVID-19. | 2020-06-19 |
| 32530776 | In contemporary clinical practice, ventilation in the prone position is indicated for patients with severe acute respiratory distress syndrome. […] The aim of this clinical review is to identify and review evidence-based recommendations developed to facilitate the selection and application of preventive interventions aimed at reducing PU development in patients ventilated in the prone position. | 2020-06-22 |
| 32530808 | Five severely ill COVID-19 patients in whom standard treatments failed were administrated with IVIG which prevented the deterioration of clinical symptoms. […] All the patients showed a desirable therapeutic response and were discharged from the hospital with a stable clinical condition after being recovered. […] Treatment with IVIG at the therapeutic dose of 0.3-0.5 g/kg can improve the clinical condition and O2 saturation and prevent the progression of pulmonary lesions in COVID-19 patients with severe symptoms in whom standard treatments have failed. | 2020-06-26 |
| 32530816 | For anosmia and ageusia, we assessed whether the respective GT correlated with Covid-19 cases and deaths both throughout 2020 and specifically before March 16, 2020 (i.e., the date when the media started reporting that those symptoms could be associated with Covid-19). […] In 15 of these countries, rises in “anosmia” and “ageusia” GT occurred in the same week or one week after they were identified in the media as symptoms of Covid-19. | 2020-06-12 |
| 32530893 | There is significant opportunity for anaesthesiologists and clinical informaticians to collaborate and apply major advances in the perioperative informatics field to NORA environments, particularly given rapid recent changes in the field during the COVID-19 epidemic. […] Given the complexity of NORA patients and care delivered in NORA environments, applied clinical informatics has the potential to drastically improve care delivered. | 2020-06-12 |
| 32530929 | RT-LAMP specifically detected SARS-CoV-2 in both simulated patient samples and clinical specimens. | 2020-06-22 |
| 32530994 | Resolution of COVID-19 symptoms was observed after six days of fever onset. […] We observed only slight fluctuations of liver enzymes, bilirubin levels and INR without clinical consequences in our case. […] We suggest testing for severe acute respiratory syndrome coronavirus on any cirrhotic patient on initial presentation, even without symptoms of COVID-19 in areas where the epidemic was prevalent. | 2020-06-19 |
| 32531040 | Due to the widespread use of this important drug class, formal proof based on clinical trials is needed to better understand the association between RASIs and complications of COVID-19. | 2020-06-26 |
| 32531046 | Most tobacco-focused clinical trials are based on locally-conducted studies that face significant challenges to implementation and successful execution. […] Multi-site clinical trials can overcome some of these hurdles but incur their own unique challenges. […] The Coronavirus Disease 2019 (COVID-19) global health pandemic has resulted in rapid requirements to shift ongoing clinical trials to remote delivery and assessment platforms, making methods for the conduct of remote trials even more timely. […] The purpose of the present manuscript it to provide an overview of available methods for the conduct of remote tobacco-focused clinical trials as well as illustrative examples of how these methods have been implemented across recently completed and ongoing tobacco studies. […] We focus on key aspects of the clinical trial pipeline including remote: 1) study recruitment and screening, 2) informed consent, 3) assessment, 4) biomarker collection, and 5) medication adherence monitoring. | 2020-06-12 |
| 32531066 | The screening of healthcare workers for COVID-19 symptoms and exposures prior to every clinical shift is important for preventing nosocomial spread of infection but creates a major logistical challenge. | 2020-06-26 |
| 32531110 | The scientific information on COVID-19 was analyzed by a literature search in Medline, Pubmed, national and international guidelines from the European Academy of Allergy and Clinical Immunology (EAACI), the Cochrane Library and the Internet. […] This international Position Paper provides recommendations on operational plans and procedures to maintain high standards in the daily clinical care of allergic patients whilst ensuring necessary safety in the current COVID-19 pandemic. | 2020-06-12 |
| 32531138 | To date, little is known about the viral shedding duration, clinical course and treatment efficacy of COVID-19 near Hubei Province, China. […] Clinical outcomes were followed up until 26 March 2020. […] The viral shedding duration, full clinical course and treatment efficacy were analysed in different subgroups of patients. […] In total, the median SARS-CoV-2 shedding period and clinical course were 12 (IQR: 9-17; mean: 13.4, 95% CI: 12.5, 14.2) and 20 (IQR: 16-24; mean: 21.2, 95% CI: 20.1, 22.3) days, respectively, and ICU patients had longer median viral shedding periods (21 [17-24] versus 11 [9-15]) and clinical courses (30 [22-33] vs. […] Current treatment with any anti-viral agent or combination did not present the benefit of shortening viral shedding period and clinical course (all p > .05) in real-life settings. […] In conclusion, the viral shedding duration and clinical course in Henan and Shaanxi Provinces were shorter than those in Hubei Province, and current anti-viral therapies were ineffective for shortening viral shedding duration and clinical course in real-world settings. | 2020-06-25 |
| 32531181 | During this period, all patients presented to the ED with symptoms suggestive of Covid-19 were included in the study. […] 41.50% of the patients presented with flu-like symptoms. | 2020-06-17 |
| 32531236 | Chinese medical workers and scientific researchers have found some drugs to play potential therapeutic effects on COVID-19 at the cellular level or in preliminary clinical trials. […] However, more fundamental studies and large sample clinical trials need to be done to ensure the efficacy and safety of these drugs. | 2020-06-28 |
| 32531325 | To describe the clinical characteristics and outcomes of hospitalized COVID-19 patients with diabetes. | 2020-06-28 |
| 32531341 | Of the 27 patients, 4 (15%) were asymptomatic, 15 (56%) showed respiratory symptoms, and 8 (30%) had gastrointestinal symptoms. […] In our study cohort, ocular manifestations of COVID-19 seem to have had a milder clinical course in pediatric patients than in adults. | 2020-06-14 |
| 32531372 | Type-2 low asthmatics may be at increased risk for adverse outcome from COVID-19 and deserve increased vigilance upon developing symptoms. | 2020-06-14 |
| 32531475 | Clinical records for COVID-19 patients were reviewed to determine the time from onset of clinical illness to testing. […] The clinical sensitivity of the assay varied depending on time from onset of symptoms, increasing with longer periods from the onset of clinical illness. […] The clinical sensitivity at ≤6 days was 8.6% (7/81; 95%CI: 3.8-17.5%), at 7-13 days 43.6% (17/39; 95%CI: 28.2-60.2%), at 14-20 days 84.0% (21/25; 95%CI: 63.1-94.7%), and at ≥21 days 84.4% (27/32; 95%CI: 66.5-94.1%). […] Clinical sensitivity was higher in the ≥14-day group compared to <14 days. […] There were no differences between the 14-20-day and ≥21-days groups; the combined clinical sensitivity for these groups (≥14 days) was 84.2% (49/57; 71.6-92.1%). […] Clinical sensitivity was limited in the early stages of disease but improved from 14 days after the onset of clinical symptoms. | 2020-06-26 |
| 32531548 | In this study, we assessed the clinical and computed tomography (CT) characteristics of PE in 23 consecutive patients with COVID-19 pneumonia and compared these to those of 100 consecutive control patients diagnosed with acute PE before the COVID-19 outbreak. | 2020-06-26 |
| 32531620 | There is limited data regarding the demographics and clinical features of SARS-CoV-2 infection in children. […] All articles that met criteria where analyzed for demographics, clinical, laboratory, radiographic, treatment and outcomes data. […] Patients presented with cough (48%), fever (47%) and sore throat/pharyngitis (28.6%), more commonly than with upper respiratory symptoms/rhinorrhea/sneezing/nasal congestion (13.7%), vomiting/nausea (7.8%) and diarrhea (10.1%). | 2020-06-25 |
| 32531713 | Furthermore, due to the NCDLR value is easily calculated, it can be widely used as a clinical biomarker for disease progression and clinical outcomes in COVID-19 patients. | 2020-06-26 |
| 32531808 | This, used in conjunction with robust in vitro and clinical data, can help in the assessment of COVID-19 therapeutics going forward. | 2020-06-12 |
| 32531860 | Acute Coronavirus disease 2019 (COVID-19) has become a global health concern associated with a broad spectrum of clinical presentations. | 2020-06-12 |
| 32531884 | Moreover, psychopathological symptoms such as anxiety, mood alterations and post-traumatic symptomatology were assessed. […] The results revealed that respectively 31.38%, 37.19% and 27.72% of respondents reported levels of general psychopathological symptomatology, anxiety, and PTSD symptoms over the cut-off scores. | 2020-06-15 |
| 32531948 | Moreover, dedicated areas should be created for the management and treatment of patients who developed COVID-19 symptoms after hospitalization (i.e., dedicated wards, operation rooms and intensive care beds). | 2020-06-15 |
| 32532077 | However, recent studies reported a high level of psychological distress and Post-Traumatic Stress Disorder (PTSD) symptoms. […] COVID-19-PTSD appears to be effective in evaluating the specific stress symptoms related to the COVID-19 pandemic in the Italian population. […] These results are relevant from a clinical point of view because they suggest that the COVID-19 pandemic could be considered as a traumatic event. | 2020-06-18 |
| 32532085 | Combinational use of these host-based antiviral agents with virus-based antivirals to target different processes of the SARS-CoV-2 replication cycle should be evaluated in animal models and/or clinical trials. | 2020-06-19 |
| 32532094 | These findings, together with accumulated clinical data regarding nafamostat’s safety, make it a likely candidate drug to treat COVID-19. | 2020-06-19 |
| 32532138 | Here, we provide epidemiological and clinical features of HCoV patients with acute respiratory infection (ARI) examined in primary care general practice. […] This study also identified symptoms associated with HCoVs in patients with ARI/ILI. […] Further studies with representative samples should be conducted to provide additional insights into the epidemiology and clinical features of HCoVs. | 2020-06-15 |
| 32532348 | The handheld ultrasound demonstrates clinical and economic value in combating COVID-19 based on interviews with frontline ultrasound physician and cardiologist as well as a national expert in medical ultrasound. | 2020-06-23 |
| 32532356 | This is a single centre, two arm ratio 1:1, triple blinded, randomized, placebo-controlled, parallel group, clinical trial. […] Twenty serious COVID-19 cases will be enrolled in the trial from April 6th to December 31st 2020. hospitalised patients at Renmin Hospital of Wuhan University satisfy all criteria as below: 1)Adults aged 18-65 years;2)Voluntarily participate in this clinical trial and sign the “informed consent form” or have consent from a legal representative.3)Diagnosed with severe pneumonia of COVID-19: nucleic acid test SARS-CoV-2 positive; respiratory distress (respiratory rate > 30 times / min); hypoxia (resting oxygen saturation < 93% or arterial partial pressure of oxygen / oxygen concentration < 300 mmHg).4)COVID-19 featured lung lesions in chest X-ray image. […] Other conditions that the researchers consider not suitable for participating in this clinical trial. […] Clinical and laboratory observations will be performed for analysis during a period of 28 days for each case since the commencement of the study. […] Primary outcome The primary outcome is Time To Clinical Improvement (TTCI). […] By definition, TTCI is the time (days) it takes to downgrade two levels from the following six ordered grades [(grade 1) discharge to (grade 6) death] in the clinical state of admission to the start of study treatments (hDPSCs or placebo). | 2020-06-22 |
| 32532449 | In Part II we describe an immunotherapeutic hypothesis worthy of the organization of a randomized clinical trial in order to ascertain whether a repurposed, generic, inexpensive, and widely available agent is capable of abolishing ‘PANIC’; thereby preventing or mitigating severe COVID-19, with monumental ramifications for world health, and the global pandemic that continues to threaten it. | 2020-06-16 |
| 32532586 | Clinical findings have been reviewed to confirm or rule out SARS-CoV-2 infection. […] Patients with COVID-19 can present few symptoms of the disease, and in PET/CT studies both presymptomatic and almost asymptomatic patients can be detected, so nuclear medicine physicians should take special attention to the pulmonary evaluation of PET/CT studies. | 2020-06-13 |
| 32532596 | It has been now well-documented that chest radiographs should be the first-line imaging tool and chest CT should only be reserved for critically ill patients, or when chest radiograph and clinical presentation may be inconclusive. […] At the time of publication, this review offers the most up-to-date recommendations for clinical practitioners in radiology departments, including radiographers. | 2020-06-25 |
| 32532623 | Here, we review the progress of developing diagnostic methods, therapies, and vaccines for SARS-CoV-2 with a focus on current clinical trials and their challenges. […] Some candidate drugs targeting different levels and stages of human responses against COVID-19 such as cell membrane fusion, RNA-dependent RNA polymerase, viral protease inhibitor, interleukin 6 blocker, and convalescent plasma may improve the clinical outcomes of critical COVID-19 patients. […] Vaccine candidates against SARS-CoV-2 are mainly based upon the viral spike protein due to its vital role in viral infectivity, and most of these candidates have recently moved into clinical trials. | 2020-06-22 |
| 32532764 | Would they be more susceptible to infection by the SARS-CoV-2 and how would their clinical course be altered by their immunosuppressed state? […] Preliminary clinical experiences based on case reports, small series and observational studies show the morbidity and mortality rates in immunosuppressed patients may not differ largely from the general population. | 2020-06-27 |
| 32532825 | Careful consideration of ethical principles must guide production of local guidance ensuring consistent patient selection thus preserving equality as well as quality of clinical services. | 2020-06-27 |
| 32532933 | To date, despite the whole world effort to review various aspects of SARS-CoV-2, including epidemiology, clinical manifestations, diagnosis, and treatment options, there are still gaps in the knowledge of this disease and many issues remain unclear. | 2020-06-22 |
| 32532934 | The different modalities of COVID-19 diagnosis discussed are: clinical and radiological, molecular based (laboratory based and point-of-care), Immunoassay based (ELISA, rapid antigen and antibody detection tests) and digital diagnostics (artificial intelligence based algorithms). | 2020-06-22 |
| 32532936 | The clinical presentation is variable, but the predominant symptoms are those of the upper respiratory tract. […] We also followed a group of 31 Bulgarian COVID-19 patients throughout the course of their disease and analyzed their symptoms (catarrhal and other) and outcome. […] Therefore, patients with acute gastrointestinal symptoms must be actively tested for SARS-CoV-2. | 2020-06-22 |
| 32532937 | In addition to the conventional respiratory symptoms, patients with COVID-19 can exhibit neurological complications. […] Two more cases have been described with Miller-Fisher syndrome or polyneuritis cranialis, both had rapidly resolving symptoms. […] In conclusion, nervous system symptoms can be observed during SARS-CoV2 infection of which headache and smell and taste disturbance are the main symptoms reported. | 2020-06-22 |
| 32532938 | This review aims to provide a summary of studies on symptoms of COVID-19 and the possible risks of COVID-19 among pregnant women, as well as complications in fetuses and neonates whose mothers were infected with COVID-19. […] The early symptoms of patients with COVID-19 were fever, cough, dyspnea, myalgia, and fatigue; while production of sputum, headache, hemoptysis, and diarrhea were other symptoms which were less common. […] The clinical findings in pregnant women with COVID-19 are not significantly different compared to other patients, and pregnant women with COVID-19 are not at a higher risk of developing critical pneumonia compared to non-pregnant women. | 2020-06-22 |
| 32532939 | Hydroxychloroquine, lopinavir/ritonavir, remdesivir, umifenovir, favipiravir, ribavirin and beta-interferon-1 gave rise to variable but still inconsistent proof of clinical efficacy in the treatment of COVID-19. | 2020-06-22 |
| 32532943 | Clinical presentation of COVID-19 is common to other respiratory infections. […] Distinctive clinical characteristics among COVID-19 were the grand-glass opacities at CT scan, and a pO2/FiO2 ratio less than 250. | 2020-06-22 |
| 32532944 | Demographic characteristics, detailed medical history, and laboratory findings of all enrolled SARS-CoV 2 infection positive patients who were referred to Patras University Hospital from the period of March 4th 2020 (when first confirmed case in Greece appeared in our hospital) until April 4th 2020 were extracted from electronic medical records and analyzed. […] Despite the retrospective nature of this study and the small number of subjects analyzed, we showed that NLR, LDH, d-dimers, CRP, fibrinogen and ferritin can be used early at the patient’s first visit for SARS-CoV 2 infection symptoms and can predict the severity of infection. […] More studies are warranted to further objectively confirm the clinical value of prognostic factors related to SARS-CoV 2 and establish an easy-to-get panel of laboratory findings for evaluating the disease severity. | 2020-06-22 |
| 32532946 | We revised the CT scan of 62 patients (34 male, 28 female, mean age 71 +/- 14 years) with clinical and laboratory signs of COVID-19, as assessed by positive SARS-CoV-2 RT-PCR testing. | 2020-06-22 |
| 32532947 | We conducted a prospective before-and-after design that used clinical simulation as a research methodology in a clinical simulation center of Colombia. | 2020-06-22 |
| 32533062 | Here, recent studies are summarized and reviewed, with a focus on virus-host interactions, vaccine-based and drug-targeted therapies, and the development of new approaches for clinical diagnosis and treatment. | 2020-06-28 |
| 32533071 | In vivo studies of animal models revealed a broad range of antiviral effects of ivermectin, however, clinical trials are necessary to appraise the potential efficacy of ivermectin in clinical setting. | 2020-06-16 |
| 32533263 | This additional mechanism may therefore explain the synergistic effect when azithromycin is added to hydroxychloroquine, leading to apparently more rapid virus clearance and better clinical benefit, when compared to monotherapy with hydroxychloroquine alone. | 2020-06-25 |
| 32533391 | Clinical, laboratory, and radiological data were collected and analyzed. | 2020-06-16 |
| 32533556 | While the medical community understands the mode of viral transmission, less is known about how long viral shedding occurs once viral symptoms have resolved. […] We found evidence of persistent viral shedding in nasopharyngeal secretions more than 2 weeks after resolution of symptoms from confirmed COVID-19 infection. | 2020-06-25 |
| 32533585 | The virus may affect the heart directly and indirectly with clinical syndromes of acute myocardial injury, myocarditis, acute coronary syndromes, heart failure, arrhythmias, and venous thromboembolism. | 2020-06-13 |
| 32533607 | The clinical appearance ranged from red to violaceous macules and dusky, purpuric plaques on the heels, soles and lateral margin of the feet, often accompanied by painful edema, consistent with chilblains. | 2020-06-13 |
| 32533613 | The aim of this study was to describe the epidemiological and clinical features of emergency department (ED) patients with suspected and confirmed COVID-19. […] Current guidelines recommend testing for patients with fevers or chills, acute respiratory symptoms or a high-risk exposure history, as well as implementation of infection control and prevention (IPC) precautions for all suspected and confirmed cases. | 2020-06-13 |
| 32533615 | The clinical course and outcomes of immunocompromised patients, such as transplant recipients, with COVID-19 remains unclear. | 2020-06-13 |
| 32533621 | Here, we summarize the general guidelines for oral health-care specialists for prevention of nosocomial transmission of COVID-19, and provide specific recommendations for clinical care management. | 2020-06-13 |
| 32533661 | In the face of the pandemic, the authorities of the Autonomous Community of Madrid led an unprecedented transformation of hospital services by increasing the number of beds available, setting up temporary field hospitals in fairgrounds, and transforming hotels into support centers for patients with mild symptoms of COVID-19. | 2020-06-19 |
| 32533662 | Other areas affected include training, clinical trials, pharmacovigilance, and counseling boards. | 2020-06-19 |
| 32533665 | The lack of known vaccines and effective treatments has generated the need to use drugs with very little evidence for their incorporation into pharmacotherapeutic protocols agreed by the clinical team. | 2020-06-19 |
| 32533666 | Given the limited scientific evidence available, most drugs have been used off-label or in the context of clinical trials, which should be the preferred option in order to create new evidence. | 2020-06-19 |
| 32533667 | The healthcare activity highlights the daily participation of pharmacists in the two clinical sessions in which the ICU teams evaluated all cases and made decisions. […] In addition to efficient resource management, support for clinical decision-making and improvement actions, it provides the climate of inter-professional trust necessary to respond to the complexity of the critical patient and promote joint projects. | 2020-06-19 |
| 32533669 | In a setting where experimental drugs preferably tested in clinical trials are being used, the role of hospital pharmacists in interdisciplinary teams has become essential for the optimization of clinical outcomes. | 2020-06-19 |
| 32533674 | Thus, the outbreak has forced HPSs to adapt their outpatient consultation services to Telepharmacy to optimize clinical outcomes and reduce the risk of contagion. […] Three main lessons have been learned during the pandemic: the satisfactory capacity of HPS to provide outpatient pharmacy consultation services in the setting of a public health crisis; the usefulness of Telepharmacy for the clinical follow-up, healthcare coordination, outpatient counseling, and informed dispensing and delivery of medication (with a high level of satisfaction among patients); and the need to foster Telepharmacy as a complementary tool through a mixed model of outpatient pharmacy consultation service that incorporates the advantages of each procedure and adapts to the individual needs of each patient in a context of humanized healthcare. | 2020-06-19 |
| 32533675 | The health crisis resulting from the rapid spread of SARS-CoV-2 worlwide, added to the low evidence of currently used treatments has led to the development of a large number of clinical trials (CT) and observational studies. […] The objective of this study is to gather the main aspects of the clinical research studies undertaken by the Departments of Hospital Pharmacy (DHP) of Spain during the COVID-19 crisis. […] It is at this moment that hospital pharmacists emerge as key players in clinical research and are contributing to a rational, effective and safe healthcare decision-making. | 2020-06-19 |
| 32533676 | Pharmacy residency programs were significantly modified by hospital pharmacies to be able to provide the new clinical and research activities required, everyday, by the pandemic situation. | 2020-06-19 |
| 32533768 | Originally described by characteristic symptoms of fever, cough and/or shortness of breath that can rapidly progress to acute respiratory distress syndrome, it has become clear that COVID-19 has manifold clinical presentations (2-4). | 2020-06-13 |
| 32533777 | To date, no data have ever been reported to reflect the clinical features of Corona Virus Disease 2019 (COVID-19) among these patients with pre-existing ILD. […] Furthermore, logistic regression models showed neutrophils counts, pro-inflammatory cytokines (TNF-α, IL6, IL1β, IL2R), and coagulation dysfunction biomarkers (D-Dimer, PT, Fbg) were significantly associated with the poor clinical outcomes of COVID-19. | 2020-06-13 |
| 32533799 | Based on clinical experience within our clinic and research programs, we aim to highlight the common challenges clinicians may encounter in providing family-based treatment (FBT) via TeleHealth for children and adolescents with anorexia nervosa and bulimia nervosa. | 2020-06-13 |
| 32533838 | This review retrospectively summarizes the research status of pathological autopsy for COVID-2019 deaths in China, which will be important for the cause of death, prevention, control and clinical strategies of COVID-2019. […] We believe pathological studies from China enable to correlate clinical symptoms and pathological features of COVID-2019 for doctors and provide an insight into COVID-2019 disease. | 2020-06-26 |
| 32533844 | Informations regarding the prevalence of enanthems, their clinical features and the association with exanthem patterns and disease severity are lacking. | 2020-06-13 |
| 32533847 | Heat maps generated by the SNF’s infection prevention team to track staff and resident symptoms and SARS-CoV-2 test results to identify infection patterns. […] The initial cluster of residents with symptoms and the first confirmed case occurred on the SNF’s dementia care unit. | 2020-06-13 |
| 32533868 | There has been wide scale adoption of CCP in many HICs, which could increase if clinical trials show efficacy of use. | 2020-06-13 |
| 32533891 | A recent report by Li et al., described the presence of SARS-CoV-2 in semen samples of six patients, including two subjects who were recovering from the clinical disease. | 2020-06-13 |
| 32533899 | The relationship with SARS-CoV-2 infection was postulated, often without any laboratory, instrumental or clinical confirmation. […] We reported demographical, laboratory and clinical features, history of close contact with COVID-19 patients, presence of similar skin lesions in other family members, precipitating and risk factors for chilblain onset. | 2020-06-13 |
| 32534013 | However, diarrhea pathogens have similar clinical symptoms and are difficult to diagnose clinically. | 2020-06-16 |
| 32534042 | Although COVID-19 is characterized by fever and respiratory symptoms, some patients have no or mild symptoms. […] We investigated gastrointestinal symptoms and shedding of virus into feces of patients with asymptomatic or mild COVID-19. […] Virus RNA was detected in feces from 2 patients without gastrointestinal symptoms (4%). […] In an analysis of fecal and respiratory specimens from patients with COVID-19 in quarantine in Korea, we found that the gastrointestinal tract could be a route of transmission of SARS-CoV-2 even in patients with asymptomatic or mild disease, with no gastrointestinal symptoms. | 2020-06-15 |
| 32534109 | Additionally, we present the clinical and laboratory differences between recovered and deceased patients highlighting the importance of cardiac manifestations. | 2020-06-16 |
| 32534175 | Regarding diagnosis, a validated screening questionnaire and digital app for COVID-19 could help identify individuals who are at risk of transmitting the disease, as well as those at highest risk for poor clinical outcomes. […] The use of acetazolamide with or without sildenafil also needs to be explored with or without heparin, since increased oxygen delivery to vital organs through prevention of thrombosis/pulmonary emboli along with carbonic anhydrase inhibition may help increase oxygenation and prevent adverse clinical outcomes. […] Digital monitoring of symptoms to clinically diagnose early exposure and response to treatment; prevention with ivermectin as well as nutritional therapies that support a healthy immune response; treatment with anti-inflammatory therapies that block NF-κB and activate Nrf2 pathways, as well as novel therapies that address COVID-19 pneumonia and ARDS with DIC including anticoagulation and/or novel respiratory therapies with or without acetazolamide and sildenafil. | 2020-06-16 |
| 32534187 | Many 3CLpro inhibitors have been proposed, and some new drug candidates have achieved success in preclinical studies. […] We also discuss the clinical application prospects and limitations of 3CLpro inhibitors for COVID-19 treatment. | 2020-06-16 |
| 32534188 | The symptoms are similar to influenza like, breathlessness, sore throat and fatigue therefore, infected person is isolated and administrated with effective treatments. […] This review focuses on epidemiology, symptoms, transmission, pathogenesis, ongoing available treatments and future perspectives of SARS-CoV-2. | 2020-06-16 |
| 32534189 | Since the most severe clinical manifestation of COVID-19 appeared to be a severe acute respiratory syndrome, azithromycin has been proposed as a potential treatment. […] At the same time there are multiple clinical evidences of the role of azithromycin in acute respiratory distress syndrome and against MERS. […] However, based on preclinical and clinical evidences and some preliminary results in COVID-19, azithromycin could have a potential in the fight against this new disease. | 2020-06-16 |
| 32534210 | The clinical outcomes of these operative patients were monitored up to 12 May 2020, the final date of follow-up, a minimum of 15 days after all patients were discharged from the hospital. […] COVID-19 infection, mortality, demographic, clinical, and laboratory data were analyzed. | 2020-06-15 |
| 32534244 | We combined these clinical and laboratory variables, with the aim of developing a score to weight the risk of COVID-19 in patients with cancer. | 2020-06-26 |
| 32534337 | In addition, cardiac symptoms, including fulminant myocarditis, are frequent in patients in a severe state of illness. | 2020-06-26 |
| 32534344 | Overall, the proposed model substantially advances the current radiology based methodology and during COVID-19 pandemic, it can be very helpful tool for clinical practitioners and radiologists to aid them in diagnosis, quantification and follow-up of COVID-19 cases. | 2020-06-26 |
| 32534369 | The Food and Drug Administration (FDA) warned against the use of Hydroxychloroquine or chloroquine for Covid-19 outside of a hospital or a clinical trial setting due to the risk of QT interval prolongation, ventricular tachycardia and the increased risk of these complications when combined with some antibiotics such as azithromycin. | 2020-06-23 |
| 32534432 | With restrictions on face to face clinical consultations in the COVID-19 pandemic, Telemedicine has become an essential tool in providing continuity of care to patients. […] Telemedicine has become an integral part to support patient’s clinical care in the current COVID-19 pandemic now and will be in the future for both primary and secondary care. | 2020-06-26 |
| 32534458 | No infants had clinical evidence of symptomatic COVID-19 infection. | 2020-06-13 |
| 32534467 | Clinical evidence indicates that the fatal outcome observed with severe acute respiratory syndrome-coronavirus-2 infection often results from alveolar injury that impedes airway capacity and multi-organ failure-both of which are associated with the hyperproduction of cytokines, also known as a cytokine storm or cytokine release syndrome. […] Clinical reports show that both mild and severe forms of disease result in changes in circulating leukocyte subsets and cytokine secretion, particularly IL-6, IL-1β, IL-10, TNF, GM-CSF, IP-10 (IFN-induced protein 10), IL-17, MCP-3, and IL-1ra. […] Not surprising, therapies that target the immune response and curtail the cytokine storm in coronavirus 2019 (COVID-19) patients have become a focus of recent clinical trials. […] With an emphasis on immune modulation, we also look at ongoing clinical studies aimed at blocking proinflammatory cytokines; transfer of immunosuppressive mesenchymal stem cells; use of convalescent plasma transfusion; as well as immunoregulatory therapy and traditional Chinese medicine regimes. | 2020-06-13 |
| 32534506 | We think there are clinical clues for dry cough and the presumed aggravating role of ACE inhibitors like captopril on the disease process. […] Thereby, we speculated that inhibition of bradykinin synthesis and/or blockade of bradykinin B2 receptor using Aprotinin/ecallantide and Icatibant, respectively, may hold therapeutic promise in severe cases and these molecules can be advanced to clinical trials. | 2020-06-18 |
| 32534626 | These results suggest that most of the population of Geneva remained uninfected during this wave of the pandemic, despite the high prevalence of COVID-19 in the region (5000 reported clinical cases over <2·5 months in the population of half a million people). | 2020-06-14 |
| 32534633 | We completed a modified Delphi consensus process of three rounds with 40 international experts in head and neck cancer surgical, radiation, and medical oncology, representing 35 international professional societies and national clinical trial groups. | 2020-06-14 |
| 32534848 | OB group showed a worse pulmonary clinical picture, with lower PaO2 (57 ± 15 vs. 68 ± 14 mmHg, p = 0.042), and SaO2 (88 ± 6 vs. 92 ± 5%, p = 0.049) at admission consequently requiring higher volumes of oxygen (Fi02: 38 ± 15 vs. 29 ± 19%, p = 0.047) and a longer period to achieve oxygen weaning (10 ± 6 vs. 15 ± 7 days, p = 0.03). | 2020-06-28 |
| 32534909 | COVID-19 is a pandemic infection due to a novel coronavirus (SARS-CoV-2) spreading, resulting in a wide range of clinical features, from asyntomatic carriers to acute respiratory distress syndrome. | 2020-06-28 |
| 32534910 | During this period, 11 patients (15%) developed symptoms consistent with coronavirus disease 2019 (COVID-19) and four (5%) tested positive. […] Two patients developed symptoms requiring hospitalisation. […] All four are alive 32-45 d after their first symptoms and 28-38 d after testing positive. | 2020-06-14 |
| 32534945 | Previous studies described the clinical characteristics of COVID-19, but knowledge gaps remain in the Middle East region. […] A multi-center, retrospective cross-sectional study was initiated to describe the demographic data, clinical characteristics, and outcomes of COVID-19 cases across all the regions of Saudi Arabia. […] Demographic data, clinical characteristics, incubation periods, laboratory findings, and patient outcomes data were retrieved from 1519 cases in the Health Electronic Surveillance Network Database. […] The most common symptoms were cough (89.4%), fever (85.6%), and sore throat (81.6%); 20.1% of the patients had underlying comorbidities. […] We could not completely assess the clinical courses or final outcomes of COVID-19 patients. […] In this multi-center retrospective study, fever and cough were common symptoms. | 2020-06-14 |
| 32534982 | Patients that tested positive for COVID-19 more frequently showed non-specific inflammatory symptoms (89.7% vs. | 2020-06-14 |
| 32535032 | Based on many preclinical studies and observational data in humans, ARDS may be aggravated by vitamin D deficiency and tapered down by activation of the vitamin D receptor. […] Several randomized clinical trials using either oral vitamin D or oral Calcifediol (25OHD) are ongoing. | 2020-06-14 |
| 32535142 | To characterize PR interval behavior in hospitalized COVID-19 patients, and correlate with clinical outcomes. […] Clinical endpoints were death or need for endotracheal intubation. | 2020-06-14 |
| 32535147 | In this cohort of COVID-19 patients, ibuprofen use was not associated with worse clinical outcomes, compared with paracetamol or no antipyretic. | 2020-06-23 |
| 32535156 | This systematic review and meta-analysis examined the detection rate of SARS-CoV-2 RNA in fecal specimens of these patients according to their clinical characteristics. […] 53.5%), those who presented with gastrointestinal symptoms (77.1% vs. | 2020-06-23 |
| 32535188 | Clinical and radiological features at admission and predictors of clinical outcomes were evaluated. […] Median (IQR) days from COVID-19 symptoms onset was 8 (5-11) days. | 2020-06-27 |
| 32535232 | Emerging genetic and clinical evidence suggests similarities between COVID-19 patients and those with severe acute respiratory syndrome and Middle East respiratory syndrome. | 2020-06-26 |
| 32535294 | It should be remembered that non-specific symptoms such as SSNHL could be the only sign with which to recognize a COVID-19 case. | 2020-06-28 |
| 32535301 | Since the outbreak of Coronavirus Disease 2019 (COVID-19) in Wuhan, considerable attention has been paid on its epidemiology and clinical characteristics in children patients. […] We analyzed and compared their clinical manifestations, imaging characteristics and treatments. […] The proportions of cough (70.2%), fever (54.4%) and gastrointestinal symptoms (14.1%) in COVID-19 patients were lower than those of influenza A patients (98.3%, P<0.001; 84.7%, P<0.001; and 35.6%, P=0.007; respectively). […] The clinical manifestations and laboratory tests of COVID-19 children are milder than those of influenza A children under 5 years. | 2020-06-14 |
| 32535302 | Unlike seasonal human coronaviruses HKU1, NL63, OC43 and 229E which are associated with mild symptoms (Corman et al., 2018), SARS-CoV-2 can cause pneumonia and severe acute respiratory syndrome (Andersen et al., 2020). […] The SARS-CoV-2 assay was originally developed as a real-time RT-PCR duplex assay covering two highly conserved target genes (RdRp and E) reported with the same fluorophore and showing a verified combined limit of detection (LoD) of 500 copies/mL in clinical samples (QIAstat-Dx Respiratory SARS-CoV-2 Panel, 2020). […] A specimen is considered positive for 2019-nCoV if both assays are positive.National Microbiology Data Center, 2020HKU paneld2RdRp, NThe N gene RT-PCR is recommended as a screening assay and the Orf1b assay as a confirmatory one (the N gene assay is about 10 times more sensitive than the ORF-1b gene assay in detecting positive clinical specimens). | 2020-06-28 |
| 32535397 | The novel respiratory virus SARS-CoV-2, responsible for over 380,000 COVID-19 related deaths, has caused significant strain on healthcare infrastructure and clinical laboratories globally. […] Nasopharyngeal swabs submitted to UW Virology for SARS-CoV-2 clinical testing were extracted, amplified by our laboratory developed test (LDT) - a CDC-based quantitative reverse transcriptase PCR reaction - and analyzed for agreement between the multiplexed assay. | 2020-06-26 |
| 32535508 | The general fear of getting infected and the importance given to personal hygiene, may have a negative impact on this clinical population. […] In a group of patients with OCD who had completed an evidence-based therapeutic path for OCD before the quarantine, this study evaluated the changes on OCD symptoms during the quarantine and investigated the effects of contamination symptoms and remission state before the quarantine on OCD symptom worsening during the quarantine. […] Remission status on OCD symptoms and having contamination symptoms before the quarantine were significantly associated with more elevated OCD symptom worsening during the quarantine. […] To our knowledge, this is the first study which assessed OCD symptoms at the COVID-19 time. | 2020-06-26 |
| 32535732 | The available evidence has not allowed guidelines to clearly recommend any drugs outside the context of clinical trials. […] These targeted monoclonal antibodies can dampen the downstream IL-6 signaling pathways, which can lead to decreased cell proliferation, differentiation, oxidative stress, exudation, and improve clinical outcomes in patients with evident features of cytokine-driven inflammation like persistent fever, dyspnea and elevated markers. […] There has been increased interest in evaluating these drugs with a series of clinical trials being registered and conducted in different countries. | 2020-06-17 |
| 32535787 | In this brief review, we discuss the lung ultrasound dichotomy, certainties and uncertainties, describing its potential role in validated clinical contexts, as a clinical-dependent exam, its limits and pitfalls in a generic and off-label clinical context, as a virtual anatomical-dependent exam, and its effects on the clinical management of patients with COVID-19. | 2020-06-17 |
| 32535876 | We are discussing some of the clinical challenges and the pitfalls in molecular diagnosis of SARS-CoV-2, including the fact that a positive PCR result may not always reflect infectiousness. | 2020-06-17 |
| 32535877 | Pa-COVID-19 aims to provide comprehensive data on clinical course, pathophysiology, immunology and outcome of COVID-19, to identify prognostic biomarkers, clinical scores, and therapeutic targets for improved clinical management and preventive interventions. […] We collect data on epidemiology, demography, medical history, symptoms, clinical course, and pathogen testing and treatment. […] Outcome measures include the WHO clinical ordinal scale on day 15 and clinical, functional, and health-related quality-of-life assessments at discharge and during follow-up. […] Registered at the German registry for clinical studies (DRKS00021688). | 2020-06-17 |
| 32535885 | Patients with a diagnosis of interstitial pneumonia caused by SARS-CoV-2, presenting with mild symptoms, and requiring hospitalization in a non-intensive care unit with known discharge status were prospectively collected and retrospectively analyzed. […] Demographical, clinical and biochemical parameters were recorded, as need for non-invasive mechanical ventilation and admission in intensive care unit. […] In-hospital mortality of patients with COVID-19 presenting with mild symptoms is high and is associated with older age, platelet count and ferritin levels. […] Identifying early predictors of outcome can be useful in the clinical practice to better stratify and manage patients with COVID-19. | 2020-06-14 |
| 32535943 | Its clinical presentation is mainly characterized by cough, fever and dyspnea, although many other symptoms have been described within its presentation pattern. […] The first report of cutaneous manifestations described different forms of skin lesions such as erythematous rash, urticaria and chicken-pox-like vesicles.2 Further studies have classified 5 different type of skin lesions, and associated them with patient demographics, timing in relation to symptoms of the disease, severity and prognosis. | 2020-06-14 |
| 32535946 | Our participant sample comprised of clinical and non-clinical staff working in COVID-19 and non-COVID-19 areas of the hospital. […] Data comprised of demographic data, current occupation (shown in Table 1), duration of symptoms, past medical history, regular medication and treatment interventions. […] An analysis of the clinical diagnoses seen are reported in Table 2. | 2020-06-14 |
| 32535955 | Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a “cytokine storm” leading to acute respiratory distress syndrome, endothelitis, thrombo-embolic complications and multiorgan failure. […] Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. […] However, basic and clinical research on COVID-19-related topics should be based on more coordinated high-quality studies. […] This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19 and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development and epidemiology. | 2020-06-14 |
| 32535977 | Clinical presentation includes unrelenting fever, variable rash, conjunctivitis and abdominal pain, progressing to hemodynamic shock with severe myocardial involvement. | 2020-06-14 |
| 32535979 | The main clinical symptoms are fever, dry cough and dyspnea, although new symptoms are emerging, such as diarrhea, anosmia and ageusia. | 2020-06-14 |
| 32536150 | To compare the virological and clinical responses to lopinavir-ritonavir and hydroxychloroquine treatment in COVID-19 patients. […] Time to negative conversion of viral RNA, time to clinical improvement, and safety outcomes were assessed after 6 weeks of follow-up. […] The median duration of symptoms before treatment was 7 days and 26 patients (40%) required oxygen support at baseline. […] There was no significant difference in time to clinical improvement between lopinavir-ritonavir- and hydroxychloroquine-treated patients (median, 18 days vs. 21 days). […] Lopinavir-ritonavir was associated with more rapid viral clearance than hydroxychloroquine in mild to moderate COVID-19, despite comparable clinical responses. | 2020-06-15 |
| 32536436 | Oral and maxillofacial surgery (OMS) clinical practice uniquely exposes providers to COVID-19. […] Almost all residents (96.5%) reported modifications to their training program, and 14% had been reassigned to off-service clinical rotations (eg, medicine, intensive care unit). […] Sweeping alterations to OMS clinical practice have occurred for those in OMSRTPs during the COVID-19 pandemic. | 2020-06-15 |
| 32536478 | The clinical course of COVID-19 presents a broad spectrum, being asymptomatic in some individuals while following a severe course and resulting in mortality in others. […] It is known that such factors as age and chronic diseases can result in a different clinical courses in individuals, however, variable clinical courses among the similar individuals in terms of age and chronic diseases are also seen. […] Whether the source of transmission is important in the clinical course of the disease is unknown. […] The similar and different clinical, laboratory and radiological findings of the cases residing in the same nursing home, who presented to the hospital altogether, were evaluated. […] The aim of the study was to analyze whether the source of transmission is influential in the clinical course of the disease. | 2020-06-15 |
| 32536564 | Several clinical trials are currently ongoing for anti-viral drugs, vaccines, and neutralizing antibodies against COVID-19. | 2020-06-15 |
| 32536670 | Thus, the effect on blood uric acid levels was subclinical in most studies. | 2020-06-19 |
| 32536738 | Owing to huge variations in clinical symptoms exhibited by COVID-19, the proposed model aims to reflect better on the current scenario and case data reported, such that the spread of the disease and the efficiency of the control action taken can be better understood. | 2020-06-15 |
| 32536761 | Hence, in this paper, we propose a new deterministic compartmental model based on the clinical progression of the disease, the epidemiological state of the individuals and the intervention for the dynamics of COVID-19 infections. | 2020-06-15 |
| 32536944 | Symptoms associated with COVID-19 include fever, cough, and shortness of breath. […] Some patients develop other symptoms like diarrhea. | 2020-06-15 |
| 32536965 | This study aims to explore the mechanism of action of DYY in the treatment of COVID-19 with the hope of providing a theoretical basis for its clinical application. […] Finally, before and after application of DYY, the core target gene IL6 of COVID-19 patients was detected by ELISA to validate the clinical effects. […] Finally, clinical studies showed that the level of IL6 was elevated in COVID-19 patients, and DYY can reduce its levels. […] DYY may treat COVID-19 through multiple targets, multiple channels, and multiple pathways and is worthy of clinical application and promotion. | 2020-06-15 |
| 32536988 | Clinical presentations range from asymptomatic or mild symptoms to severe illness. […] Pending the availability of a vaccine, there is a critical need to identify effective treatments and a number of clinical trials have been implemented worldwide. […] Most of those emerging re-introduced drugs are administered to patients in the context of clinical trials. | 2020-06-15 |
| 32537099 | The results of a clinical trial comparing hydroxychloroquine with or without azithromycin to the standard of care for the treatment of COVID-19 were recently published by Philippe Gautret et al. […] The study brings useful knowledge consistent with available evidence and clinical practice from China and South Korea, which could have prompted quicker policy decision-making. | 2020-06-15 |
| 32537248 | Coronavirus disease 2019 (COVID-19) predominantly presents with symptoms of fever, fatigue, cough and respiratory failure. | 2020-06-15 |
| 32537272 | Common symptoms include fever, cough and shortness of breath, however, lack of these symptoms does not exclude COVID-19. […] Given the incomplete understanding of the virus at this time, healthcare professionals must continue to remain informed of the vast number of clinical presentations of the virus to ensure early supportive treatment, ideally leading to improved outcomes. | 2020-06-15 |
| 32537424 | There was a small but significant increase in the severity of anxiety symptoms, and an increase in the number of people reporting recent onset of anxiety and depression. […] However, there were no differences between groups in severity of symptoms of distress or depression. […] With the prospect of prolonged restriction of movement, DMHS such as MindSpot could play an important role in both providing clinical services and monitoring the mental health of the population. | 2020-06-15 |
| 32537425 | As new data emerge, the spectrum of initial presenting symptoms has expanded from fever, cough, and dyspnea to gastrointestinal and other symptoms in both pregnant and non-pregnant patients. […] To date, no cases of human pancreatitis have been identified as related to a COVID-19 infection, although multiple other gastrointestinal symptoms have been described. | 2020-06-15 |
| 32537484 | We conducted a national survey aiming to assess the impact of the COVID-19 outbreak on endoscopic clinical practice in Brazil. Methods In April 2020, 3,719 associate members of SOBED (Brazilian Society of Digestive Endoscopy) were invited to respond to an electronic survey. | 2020-06-15 |
| 32537529 | EEGs were interpreted by board-certified clinical neurophysiologists (n = 16). […] EEG findings were correlated with demographic data, clinical presentation and history, and medication usage. […] This is the first preliminary report of EDs in the EEG of acutely ill COVID-19-positive patients with encephalopathy or suspected clinical seizures. | 2020-06-25 |
| 32537610 | Aprotinin is a nonspecific protease inhibitor especially of trypsin, chymotrypsin, plasmin, and kallikrein, and it is many years in clinical use. | 2020-06-15 |
| 32537614 | However, I became critically unwell following a week of clinical work, necessitating hospital admission, tracheal intubation and mechanical ventilation. | 2020-06-23 |
| 32537662 | Thus, formation of a competent Cardio-COVID-19 team may represent a major clinical measure to optimize therapy of cardiovascular patients during this pandemic. | 2020-06-19 |
| 32537704 | Coronavirus disease of 2019 (COVID-19) can be associated with high morbidity and mortality; patients with severe clinical manifestations may develop significant coagulopathy as well as unexpected thromboembolic complications. | 2020-06-19 |
| 32537771 | There was excellent reliability between the two raters (intraclass correlation coefficient = 0.96). 55% of the videos discussed prevention, 49% discussed symptoms and 46% discussed the spread of the virus. | 2020-06-15 |
| 32537852 | The literature search included peer-reviewed articles published in English language (clinical trials or scientific reviews). | 2020-06-15 |
| 32537930 | Patient-centred communication and shared decision-making should continue to remain central to clinical practice. | 2020-06-26 |
| 32537954 | Demographic, clinical, laboratory, and outcome data were collected and analyzed. | 2020-06-18 |
| 32537957 | We reviewed medical records of 98 patients aged ≥ 65 years who were hospitalized with COVID-19 during a regional outbreak in Daegu/Gyeongsangbuk-do province of Korea. […] CRP > 8.0 mg/dL was strongly associated with MV/HFNC (odds ratio, 26.31; 95% confidence interval, 7.78-88.92; P < 0.001), and showed better diagnostic characteristics compared to commonly used clinical scores. | 2020-06-18 |
| 32538004 | To observe clinical effect of heat-sensitive moxibustion on coronavirus disease 2019 (COVID-19) and to discusses the effective moxibustion treatment program. […] The heat-sensitive moxibustion can effectively reduce the negative emotions and improve the symptoms of chest distress and impaired appetite with COVID-19. […] It is generally accepted by patients, and worthy of popularization and application in clinical treatment. | 2020-06-17 |
| 32538157 | As a response to clinical observations that the pervasive stress and social/environmental disruptions from the 2020 COVID-19 pandemic have also impacted sleep, the Society of Behavioral Sleep Medicine (SBSM) convened the COVID-19 Task Force with goals to identify and disseminate information that could be useful in addressing sleep concerns during this crisis. Participants Members of the SBSM COVID-19 Task Force. Results/Conclusions Herein is a summary of the resources developed by the SBSM COVID-19 Task force, which includes links to online materials developed for use by providers and patients, as well as brief descriptions of key recommendations by the Task Force for specific sleep conditions (e.g., acute insomnia, nightmares) and vulnerable populations (e.g., parents, essential/healthcare workers, older adults). | 2020-06-15 |
| 32538209 | However, some drugs were withdrawn due to their side effects after demonstrating some clinical efficacy. | 2020-06-15 |
| 32538518 | The most common symptoms in children with confirmed and suspected COVID-19 include fever and cough followed by diarrhea, and abdominal pain. | 2020-06-15 |
| 32538594 | Diagnostic criteria include onset within one week of a known insult or new or worsening respiratory symptoms, profound hypoxemia, bilateral pulmonary opacities on radiography, and inability to explain respiratory failure by cardiac failure or fluid overload. | 2020-06-16 |
| 32538775 | For this reason, while new drug development studies are continuing, in order to be beneficial to patients in their acute period, it is imperative that we are able to come up with drugs that activate or inhibit these pathways and are currently in clinical use. | 2020-06-26 |
| 32538806 | The authors defined different priorities for the different clinical situations in PC. | 2020-06-18 |
| 32538807 | The guidelines and recommendation sof good clinical practice have been disrupted by new and urgent policies, marked by the COVID-19 pandemic. | 2020-06-18 |
| 32538809 | Besides, providing active surveillance on non-risk factor clinical stage I is alsoa priority. | 2020-06-18 |
| 32538810 | Lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH) has a high prevalence and is related to high consumption of health resources. […] A group of experts in benign prostatic hyperplasia from different regions of Spain were selected to design a strategy to reorganize the management of benign prostatic hyperplasia and lower urinary tract symptoms during the pandemic. | 2020-06-18 |
| 32538813 | CONCLUSIONS: The change that COVID-19 Pandemich as involved in our clinical practice force us to seek alternative methods to treat our patients, some of which may already be established. | 2020-06-18 |
| 32538814 | CONCLUSIONS: In neurourological patients we can find exceptional clinical situations in which a delayed treatment could develop irreversible changes in the upper urinary tract, advocating a more urgent treatment inspecific scenarios. | 2020-06-18 |
| 32538816 | Screening for the SARS-CoV-2 virus should be done in all those donors and recipients with clinical symptoms consistent with COVID-19, who have visited or live inhigh-risk areas, or who have been in close contact with confirmed cases of COVID-19. […] Kidney transplant surgery must be efficient in terms of health, human resources, and clinical benefit. | 2020-06-18 |
| 32538818 | SARS-CoV-2screening 72 hours prior to surgery by clinical and epidemiological questionnaire and nasopharyngeal PCRis recommended, in order to prevent nosocomial transmission, professional infections and to minimize postoperative complications. | 2020-06-18 |
| 32538857 | In this article, we review the reports that address neurological manifestations in patients with COVID-19, who may present with acute neurological symptoms (e.g., stroke), even without typical respiratory symptoms such as fever, cough, or shortness of breath. | 2020-06-15 |
| 32538870 | Telemedicine is now being introduced as a bridge to restart clinical trials and will increasingly become a normal part of future research studies. | 2020-06-15 |
| 32538893 | The symptoms are dominantly fever, fatigue, and dry cough, and can be complicated with tiredness, sore throat, and headache. […] A few patients have symptoms such as stuffy nose, runny nose, and diarrhea. | 2020-06-23 |
| 32538995 | Except for pregnant women, the management of critically ill patients with COVID-19 during the pandemic includes the standard procedures that are used for any patient that requires to be attended to at the intensive care unit, as well as limited administration of crystalloid solutions, orotracheal intubation, invasive mechanical ventilation in the event of patient clinical deterioration, and muscle relaxants continuous infusion only if necessary. | 2020-06-22 |
| 32539016 | In Mexico, social distancing is being applied, but studies are still required on the dynamics of the epidemic, person-to-person transmission, incidence of subclinical infections, and patient survival. | 2020-06-22 |
| 32539253 | To evaluate the impact of COVID-19 on clinical practice, income, health and lifestyle behavior of Brazilian urologists during the month of April 2020. […] The primary goal was to evaluate changes in urologists’ clinical practice and income after two months of COVID-19. | 2020-06-16 |
| 32539267 | Patients with coronavirus disease 2019 (COVID-19) with variable clinical presentations are encountered in the perioperative setting. […] We report an intraoperative diagnosis of COVID-19 in an asymptomatic patient, prompted by clinical signs. | 2020-06-18 |
| 32539299 | Guidelines for clinical laboratories on the COVID-19 diagnosis have been recently published by Korean Society for Laboratory Medicine and the Korea Centers for Disease Control and Prevention. | 2020-06-24 |
| 32539346 | Literature data from clinical studies indicated a strong correlation between experimental and clinical findings. […] This article presents clinical studies related with SARS-CoV-2 induced smell/taste impairment that reported recovery rates. | 2020-06-16 |
| 32539586 | Of included subjects, 10% had only olfactory or gustatory symptoms, and 19% had olfactory and/or gustatory complaints prior to any other COVID-19 symptom. […] Olfactory and/or gustatory disorders may represent early or isolated symptoms of severe acute respiratory syndrome coronavirus 2 infection. | 2020-06-19 |
| 32539587 | In total, 140 patients participated in a web-based questionnaire assessing initial symptoms of common viral diseases, olfactory and taste functions, xerostomia, and orofacial pain. […] Initial symptoms were cough (59.4%), weakness (47.7%), myalgia (46.9%), fever (42.2%), headache (40.6%), impaired sense of smell (38.3%), impaired sense of taste (32.8%), sore throat (26.6%), runny nose (26.6%), and nasal congestion (22.7%). […] All symptoms were more frequent among women; however, only runny nose was statistically significant (P = .018). […] The most common combination of symptoms was cough and weakness (37.5%). […] A total of 25.8% reported olfactory and taste dysfunctions in the absence of other symptoms. […] Interestingly, women presented with a different cluster of symptoms than men, which may suggest a new clinical approach to diagnosing COVID-19 disease. | 2020-06-19 |
| 32539627 | The lung is a key target of the cytokine storm that can be triggered by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), responsible for the widespread clinical syndrome known as coronavirus disease 2019 (COVID-19). | 2020-06-26 |
| 32539692 | Patients in group 1 (n = 51) presented with symptoms of COVID-19 according to the diagnostic criteria. […] Group 2 (n = 29) patients were identified as a high degree of clinical suspicion. […] Patients in group 3 (n = 30) presented with mild symptoms and normal chest radiographs. | 2020-06-22 |
| 32539942 | Eligibility criteria were the presence of any thoracic cancer (non-small-cell lung cancer [NSCLC], small-cell lung cancer, mesothelioma, thymic epithelial tumours, and other pulmonary neuroendocrine neoplasms) and a COVID-19 diagnosis, either laboratory confirmed with RT-PCR, suspected with symptoms and contacts, or radiologically suspected cases with lung imaging features consistent with COVID-19 pneumonia and symptoms. […] Patients of any age, sex, histology, or stage were considered eligible, including those in active treatment and clinical follow-up. […] Clinical data were extracted from medical records of consecutive patients from Jan 1, 2020, and will be collected until the end of pandemic declared by WHO. […] Data on demographics, oncological history and comorbidities, COVID-19 diagnosis, and course of illness and clinical outcomes were collected. […] Associations between demographic or clinical characteristics and outcomes were measured with odds ratios (ORs) with 95% CIs using univariable and multivariable logistic regression, with sex, age, smoking status, hypertension, and chronic obstructive pulmonary disease included in multivariable analysis. | 2020-06-19 |
| 32539986 | Thus, the Diamond Princess cruise ship, which was quarantined because of an onboard outbreak of COVID-19 in February, 2020, provides an opportunity to define the shedding pattern of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and patient antibody responses before and after the onset of symptoms. | 2020-06-19 |
| 32539988 | We described the clinical features of people infected on board the Diamond Princess cruise ship who were diagnosed with asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or mild or severe COVID-19, on admission to the Self-Defense Forces Central Hospital (Tokyo, Japan) and at the end of observation. […] Clinical records, laboratory data, and radiological findings were analysed. […] Clinical outcomes were followed up until discharge or Feb 26, 2020, whichever came first. […] We defined asymptomatic infection as SARS-CoV-2 infection with no history of clinical signs and symptoms, severe COVID-19 as clinical symptoms of pneumonia (dyspnoea, tachypnoea, peripheral capillary oxygen saturation <93%, and need for oxygen therapy), and mild COVID-19 as all other symptoms. […] Clinical features on admission were compared among patients with different disease severity, including asymptomatic infection, at the end of observation. […] Older age, consolidation on chest CT images, and lymphopenia might be risk factors for disease progression of COVID-19 and contribute to improved clinical management. | 2020-06-19 |
| 32539990 | Clinical research is necessary for an effective response to an emerging infectious disease outbreak. […] In response to the needs of the rapidly evolving COVID-19 outbreak, the Clinical Characterisation and Management Working Group of the WHO Research and Development Blueprint programme, the International Forum for Acute Care Trialists, and the International Severe Acute Respiratory and Emerging Infections Consortium have developed a minimum set of common outcome measures for studies of COVID-19. […] This set includes three elements: a measure of viral burden (quantitative PCR or cycle threshold), a measure of patient survival (mortality at hospital discharge or at 60 days), and a measure of patient progression through the health-care system by use of the WHO Clinical Progression Scale, which reflects patient trajectory and resource use over the course of clinical illness. | 2020-06-19 |
| 32540054 | It summarizes data concerning COVID-19 transmission, diagnosis, and clinical presentation highlighting the information significant for otolaryngologists. | 2020-06-19 |
| 32540142 | It is hoped that through this article, surgeons will have a better system in hepatobiliary diseases classification, treatment selection, and protective measures to improve the clinical practice in accordance with the guidelines for the diagnosis and treatment of the novel coronavirus pneumonia. | 2020-06-19 |
| 32540204 | Patient characteristics symptoms and survival were collected and compared in SARS-COV-2 real-time or reverse-transcriptase PCR (RT-PCR)-positive and RT-PCR-negative patients. […] RT-PCR-positive patients were older, had more frequently haematological malignancies, respiratory symptoms and suspected COVID-19 pneumonia of computed tomography (CT) scan. […] However, respectively, 38% and 20% of SARS-COV-2 RT-PCR-negative patients presented similar respiratory symptoms and CT scan images. […] At the median follow-up of 25 days after the first symptoms, the death rate in RT-PCR-positive and RT-PCR-negative patients were 21% and 10%, respectively. […] In both groups, independent risk factors for death were male gender, Karnofsky performance status <60, cancer in relapse and respiratory symptoms. […] The survival of RT-PCR-positive and -negative patients with respiratory symptoms and/or COVID-19 type pneumonia on CT scan was similar with a 18.4% and 19.7% death rate at day 25. | 2020-06-19 |
| 32540267 | The long-term implications of this reduction in functional urology clinical activity are currently unknown. | 2020-06-19 |
| 32540268 | This study considers up-to-date information on the biological determinants shared by COVID-19 and renal disease, and aims to provide evidence-based recommendations for the clinical management of RCC patients with COVID-19. […] Evidence is discussed from epidemiological studies on SARS-CoV-2 pandemic and molecular studies on the role of kidney in facilitating routes for SARS-CoV-2 entry, leading to increased virulence of SARS-CoV-2 and clinical manifestation of symptoms in RCC. […] This analysis will advance our understanding of (1) the molecular signatures shared by RCC and COVID-19 and (2) the clinical implications of overlapping signaling pathways in the therapeutic management of RCC and COVID-19 patients. | 2020-06-19 |
| 32540345 | Several clinical trials are underway to test the effectiveness of hyperimmune plasma at various stages of SARS-CoV2. […] Below are the general indications for drawing up clinical protocols for the integral management of “COVID-19-convalescent plasma” for which the validation and approval of the Ethics Committees is still necessary. | 2020-06-19 |
| 32540367 | Vaccines are also under development and phase 1 clinical trials are rolling. […] In light of pathogenesis and proposed clinical classification, this review’s purpose is to summarize and simplify the most important updates on the management and the potential treatment of this emergent disease. | 2020-06-19 |
| 32540370 | We aimed to investigate the relationship between clinical characteristics, outcomes and the severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. […] We performed a systematic review and meta-analysis using PubMed, Embase, and Cochrane Library databases to assess the clinical characteristics and outcomes of confirmed COVID-19 cases and compared severe (ICU) and non-severe (non-ICU) groups. […] Investigation of clinical characteristics and outcomes of severe cases of COVID-19 will contribute to early prediction, accurate diagnosis, and treatment to improve the prognosis of patients with severe illness. | 2020-06-19 |
| 32540733 | The proposed drugs that are in clinical trial for COVID-19 treatment must be carefully considered for clinical use, especially in patients with MS. | 2020-06-26 |
| 32540749 | Individuals with substance user disorders (SUD) are at risk population for contamination due to multiple factors-attributable to their clinical, psychological and psychosocial conditions. | 2020-06-27 |
| 32540769 | Teleneurology in Spain had not been implemented so far in clinical practice, except in urgent patients with stroke. | 2020-06-26 |
| 32540814 | A working group of the French Society of Clinical Biology (SFBC) was set up with the objective of providing updated information on the current status of the biological prescriptions (focusing on biochemistry ones) and their evolution during the epidemic, and of analyzing the biological parameters associated with comorbidities and patient evolution in order to link biological results with medical events. […] The expanded working group covers all sectors of medical biology in France and extends to the French-speaking world: hospital sectors (CHU and CH, Army Training Hospitals) and the private sector opening a field of view on the biological situation in establishments for dependent elderly, social establishments and clinical medical institutions. | 2020-06-24 |
| 32540837 | In the midst of COVID-19 pandemic, emerging clinical data across the globe has equipped front line health care workers, policy makers and researchers to better understand and combat the illness more prepared. […] Correlation of clinical and laboratory parameters with patients requiring mechanical ventilation and mortality in patients infected with SARS-CoV-2. | 2020-06-16 |
| 32540839 | As young adults living with perinatal HIV (PHIV) or perinatal HIV exposure but uninfected (PHEU) grow older and manage the challenges and competing demands of young adulthood, new approaches are needed to facilitate their retention in longitudinal research and clinical care beyond in-person clinic visits. […] However, trusting relationships with clinical staff positively impacted their willingness to use these platforms. […] For optimal retention, pediatric clinical staff should consider communication approaches offering flexible and tailored options for young adults participating in HIV research. | 2020-06-24 |
| 32540845 | Then, we constructed a COVID-19 dynamic risk stratification model with high recall and clinical interpretability, which was based on a multi-class logistic regression algorithm. […] A total of 2243 clinical data consist of 36 dimensions clinical features from fever clinics were used for training and evaluation of the model. […] We use low risk, moderate risk and high risk as labels, and adopt a 10-fold cross-validation method to evaluate and test the COVID-19 dynamic risk stratification model in different scenarios (different dimensions of personal clinical data accessible at the early stage). […] The data set dimensions are (2243, 15) when only using the data of patients’ demographic information, clinical symptoms and contact history, (2243, 35) when the results of blood tests are added, (2243, 36) after obtaining the CT imaging results of the patient. | 2020-06-16 |
| 32540850 | The potential immune intersection between COVID-19 disease and cancer therapy raises important practical clinical questions and highlights multiple scientific gaps to be filled. […] Based on available literature evidences, we suggest guidance to consider for treating physicians, and propose areas of clinical and pre-clinical investigation. | 2020-06-16 |
| 32540882 | This case indicates the need to consider COVID-19 in a wider series of clinical presentations and to develop a validated assay for SARS-CoV-2 in the cerebrospinal fluid. | 2020-06-23 |
| 32541085 | To date, no medication supported by randomized clinical trials has been approved for the treatment of COVID-19. | 2020-06-17 |
| 32541089 | Although the respiratory illness is the most important clinical manifestation of COVID-19, a large number of patients with COVID-19 suffer from new onset cardiac dysfunction where ECG and ECG monitoring play a critical role. | 2020-06-17 |
| 32541232 | This review was conducted utilizing a rapid review methodology to enable efficient generation and dissemination of information useful for concurrent clinical practice. | 2020-06-16 |
| 32541352 | The purpose of pulmonary rehabilitation in COVID-19 patients is to improve symptoms of dyspnea, relieve anxiety, reduce complications, minimize disability, preserve function and improve quality of life. | 2020-06-16 |
| 32541471 | A 29-year-old kidney transplant recipient with the symptoms of COVID-19 pneumonia. | 2020-06-22 |
| 32541475 | We are going to search the electronic databases: PubMed, EMBASE, Cochrane library, Web of Science (WOS), Google scholar, China National Knowledge Infrastructure (CNKI), Chinese Biomedical literature Database (CBM), Chinese Scientific and Journal Database (VIP), Wan Fang database (Wanfang) for published clinical trails and search clinical trials register platforms of Chinese Clinical Trial Registry (ChiCTR) and ClinicalTrials.gov (www.ClinicalTrials.gov/) for ongoing trials of Jinhua Qinggan granule for COVID-19. […] The primary outcomes of the included studies contain Clinical symptom disappearance rate and the secondary outcomes obtain: TCM syndrome scale score, Hamilton anxiety scale score, and adverse events. | 2020-06-22 |
| 32541496 | We aim to assess the efficacy and safety of Chinese medicine in treatment of coronavirus-related pneumonia with the updated results of relevant clinical trials. | 2020-06-17 |
| 32541542 | Relevant clinical data were obtained from peer-reviewed journal articles, task force recommendations, and published guidelines from multiple medical organizations utilizing data sources including PubMed, Google Scholar, MEDLINE, and Google search queries. | 2020-06-16 |
| 32541745 | Analysis was with descriptive statistics.Results There were 1,746 patient triages (1,595 telephone and 151 face-to-face), resulting in 1,322 clinical consultations. […] Sixty-five percent of clinical consultations resulted in extractions and 0.8% in an aerosol generating procedure. | 2020-06-24 |
| 32541971 | We summarized and analyzed the clinical features, infection status, outcome and infection prevention and control measures of bedside blood purification treatment patients in COVID-19 isolation ward from February 8, 2020 to March 31, 2020, analyzed the COVID-19 cross-infection between the patients and medical staffs, and the blood-borne pathogens cross-infection situation between the patients, and analyzed the effect of bundle prevention and control measures in controlling the occurrence and spread of cross-infection. | 2020-06-17 |
| 32541972 | We collected the clinical data and laboratory examination results of the eligible patients to evaluate the related factors of death. | 2020-06-17 |
| 32542102 | The patient presented with generalized abdominal pain and nausea only, without fever or any respiratory symptoms. | 2020-06-17 |
| 32542111 | Problems may also arise because both clozapine-induced myocarditis and neutropenic sepsis share signs and symptoms with COVID-19 (fever, chest pain, dyspnoea, etc.). | 2020-06-17 |
| 32542123 | Physicians should be aware of the variable clinical presentations of COVID-19, especially in new or worsening cardiac illnesses, in order to practice the appropriate personal protection practices. | 2020-06-17 |
| 32542131 | Furthermore, disease management has been challenging for the clinicians and other medical personnel in terms of treatment options and availability of personal protective equipment. | 2020-06-17 |
| 32542159 | Coronavirus disease 2019 (COVID-19) is currently the causative agent for a global health emergency and is predominantly associated with respiratory symptoms. […] Given the patient’s lack of respiratory symptoms, diagnosis and treatment were ultimately delayed. | 2020-06-17 |
| 32542177 | We present a case of a previously healthy patient who developed classic symptoms of appendicitis. | 2020-06-17 |
| 32542188 | In this report, we discuss the clinical utility of POCUS in diagnosing thrombus in transit in COVID 19 populations. | 2020-06-19 |
| 32542206 | Coronavirus disease 2019 (Covid-19) has non-specific clinical and laboratory characteristics that might be similar to other viral infection including dengue. | 2020-06-17 |
| 32542210 | Coronavirus disease 2019 (COVID-19) is predicted to overwhelm health care capacity in the United States and worldwide, and, as such, interventions that could prevent clinical decompensation and respiratory compromise in infected patients are desperately needed. […] Contact activation has been linked to pathologic upregulation of both inflammatory mediators and coagulation, and accumulating preclinical and clinical data suggest it to be a rational therapeutic target in patients with COVID-19. […] As a few drugs targeting contact activation are already in clinical development, immediate clinical trials for their use in patients with COVID-19 are potentially feasible for the prevention or treatment of respiratory distress. | 2020-06-17 |
| 32542212 | Although the full scope of the benefits from heparin for COVID-19 patients is unfolding, encouraging clinical data suggest that heparin-like molecules may represent a useful approach to treat or prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. | 2020-06-17 |
| 32542213 | Thrombotic coagulopathy is present in nearly three quarters of patients with COVID-19 admitted to the intensive care unit, and both the clinical picture and pathologic findings are consistent with microvascular occlusive phenomena being a major contributor to their unique form of respiratory failure. | 2020-06-17 |
| 32542238 | The aim of our study was to compare the characteristics of loss of smell and taste between patients with a clinical diagnosis of SARS-CoV-2 infection to patients with a RT-PCR diagnosis. | 2020-06-16 |
| 32542337 | However, many medical professional societies recommended their continued use given the paucity of clinical evidence, but there is a need for an updated systematic review and meta-analysis of the latest clinical studies. […] A search was conducted on PubMed, Google Scholar, EMBASE, and various preprint servers for studies comparing clinical outcomes and mortality in COVID-19 patients on ACEIs and/or ARBs, and a meta-analysis was performed. | 2020-06-26 |
| 32542349 | Both the research and policy recommendations included in this commentary emphasize equity-driven: (1) research practices, including applying a social determinants and health equity lens on monitoring, evaluation, and clinical trials activities on COVID-19; and (2) policy actions, such as dedicating resources to prioritize high-risk communities for testing, treatment, and prevention approaches and implementing organizational, institutional, and legislative policies that address the social and economic barriers to overall well-being that these populations face during a pandemic. | 2020-06-16 |
| 32542429 | This ecological perspective coupled with many limitations does not provide a direct clinical relevance between the COVID-19 and RAS system, but it shows potential pathophysiological associations. | 2020-06-25 |
| 32542552 | An online questionnaire was created and it consisted of 12 questions testing their knowledge about COVID-19 clinical characteristics, transmission routes and prevention and control steps. | 2020-06-19 |
| 32542615 | Clinical manifestations of COVID-19 in children are generally mild and many are asymptomatic. | 2020-06-25 |
| 32542706 | We would like to report the clinical characteristics of 3 people living with HIV (PLWH) in the United Kingdom within the context of coronavirus disease 2019 (COVID-19). | 2020-06-16 |
| 32542735 | However, the symptoms of the disease and the clinical outcome are very different in infected people. | 2020-06-16 |
| 32542750 | Thirty-three children had COVID-19 (20 pneumonia) with mild symptoms and 10 were asymptomatic. | 2020-06-16 |
| 32542785 | Agents that inhibit components of the pro-inflammatory cascade have garnered interest as potential treatment options with hopes that dampening the pro-inflammatory process may improve clinical outcomes. […] In this article we review available data on baricitinib with an emphasis on immunosuppressive and antiviral pharmacology, pharmacokinetics, safety and current progress in COVID-19 clinical trials. | 2020-06-16 |
| 32542847 | Until data from clinical studies are available to provide solid evidence for worldwide applicable guidelines, there is a need to provide guidance to the transfusion community and researchers on this emergent therapeutic option. […] This paper aims to identify existing key gaps in current knowledge in the clinical application of COVID-19 convalescent plasma (CCP). […] A subgroup of clinical transfusion professionals was formed to draft a document for CCP clinical application to identify the gaps in knowledge in existing literature. […] This paper outlines a framework of gaps in the knowledge of clinical deployment of CPP that were identified as being most relevant. | 2020-06-16 |
| 32542914 | Immunosuppression is considered a risk factor for more severe clinical presentation of COVID-19. […] Limited data regarding clinical outcome exist in adults, whereas very little is known about the spectrum of the disease in pediatric heart transplant recipients. […] We present four cases with COVID-19 disease and elaborate on their presentation and clinical course. […] Although far from conclusive and limited by the small sample size and selection bias, these cases demonstrate mild and self-limited disease despite immunosuppressive therapy and various comorbidities that are expected to increase the severity of the clinical picture based on extrapolation from the adult experience with this novel disease. | 2020-06-28 |
| 32542928 | The worldwide diffusion of coronavirus disease 2019 (COVID-19) is characterized by various clinical presentations and different related complications. | 2020-06-16 |
| 32542934 | In December 2019 a novel viral respiratory pathogen emerged in China, ultimately named severe acute respiratory syndrome coronavirus 2 (SARS-Co-V-2) with the clinical illness dubbed coronavirus disease (COVID-19). […] Diagnosing COVID-19 was hampered by inadequate supplies of reagents and kits, which was compounded by clinical and radiographic features that overlap with numerous seasonal viral respiratory infections. | 2020-06-16 |
| 32542964 | We review pathogenesis and clinical characteristic of COVID-19, as well as treatment options that have been under evaluation in past several months. […] In addition, we focus more on Chloroquine and Hydroxychloroquine, their pharmacological properties, clinical utility, and current recommendations for their use in COVID-19. | 2020-06-16 |
| 32543119 | Hence, there is a clinical paradox where plasmin formation can be either deleterious or beneficial in COVID-19, but not at the same time. | 2020-06-16 |
| 32543154 | Clinical data and CT images of 23 patients diagnosed with COVID-19 in West China Hospital of Sichuan University were retrospectively collected, and the chest CT findings were summarized and analyzed. | 2020-06-17 |
| 32543229 | Ethically, it is vital that research outputs during a pandemic be robust because clinical decision-making may reflect on these research results. | 2020-06-16 |
| 32543260 | Case 1 is an 88-year-old female with acute left hemiplegia and right peripheral facial paresis that she had a fever along with stroke symptoms. […] Case 3 is a 55-year-old male with acute Broca’s aphasia and right hemiplegia who experience fever and respiratory problems 3 days after admission.Results: The clinical symptoms of infected patients with COVID-19 have been associated with severe symptoms of ischemic stroke. | 2020-06-25 |
| 32543298 | Clinical performances of AIGS assay were assessed in 266 suspected COVID-19 clinical respiratory tract samples tested in parallel with a commercial kit. […] The clinical sensitivity of AIGS test was 97.62% (95%CI:0.9320-0.9951) based on the commercial kit test result , and concordance analysis showed a high agreement in SARS-CoV-2 detection between the two assays, Pearson R was 0.9623 (95% CI:0.9523-0.9703). | 2020-06-16 |
| 32543348 | The evolutionary pattern of SARS-CoV-2 towards FCS formation may result in its clinical symptom becoming closer to HKU-1 and OC43 (the source of FCS sequence-PRRA) caused mild flu-like symptoms, further showing potential in differentiating into mild COVID-19 subtypes. | 2020-06-19 |
| 32543702 | Data on the clinical characteristics and outcomes of infected patients in urban communities in the US are limited. […] To describe the clinical characteristics and outcomes of patients with coronavirus disease 2019 (COVID-19) and to perform a comparative analysis of hospitalized and ambulatory patient populations. […] Demographic data, underlying comorbidities, clinical presentation, complications, treatment, and outcomes were collected. […] Common symptoms at presentation were cough (347 patients [74.9%]), fever (315 patients [68.0%]), and dyspnea (282 patients [60.9%]). | 2020-06-24 |
| 32543703 | We demonstrate that the general clinical conditions, risk factors and numerous pathological and biological features of COVID-19 are analogous with various disorders caused by the uncontrolled formation of neutrophil extracellular traps and their by-products. […] Given the rapid evolution of this disease’s symptoms and its lethality, we hypothesize that SARS-CoV2 evades innate immune response causing COVID-19 progresses under just such an amplifier loop, leading to a massive, uncontrolled inflammation process. | 2020-06-25 |
| 32543710 | COVID-19 patients with comorbidities had worse clinical outcomes as compared to those without any comorbidity. | 2020-06-16 |
| 32543722 | The Asymptomatic novel CORonavirus iNfection (ACORN) study was designed to investigate the prevalence of SARS-CoV-2 infection in the asymptomatic adult population of the Indianapolis metropolitan area, to follow individuals testing positive for the development of symptoms, and to understand duration of positive test results. […] ACORN is a cross-sectional community-based observational study of adult residents presenting asymptomatic for COVID-like illness, defined as the self-reported absence of the following 3-symptoms in the last 7-days: fever (≥100°F), new onset or worsening cough, and new onset or worsening shortness of breath. […] Within the ongoing 14-day follow-up period for positive participants, 58 (71.6%) of 81-assessed participants remained asymptomatic while others (n=23, 28.4%) reported one or more symptoms. | 2020-06-16 |
| 32543753 | The detection data of IgM and IgG antibodies in 169 patients with coronavirus disease (COVID-19) were analyzed to evaluate differences in clinical performance between the colloidal gold method and chemiluminescence method. […] A reasonable understanding of the performance of reagents with different methodologies can help in clinical disease diagnosis effectively and assist in the diagnosis of the progression of COVID-19, for which the dynamic changes of antibody will provide reliable evidence. | 2020-06-16 |
| 32543756 | The clinical and laboratory information including routine blood tests, blood biochemistry, lymphocyte subsets, immunoglobulins, cytokines and inflammatory factors were analyzed retrospectively in 127 patients. | 2020-06-16 |
| 32543757 | The coronavirus disease (COVID-19) resulting from SARS-CoV-2 manifests in variable clinical severity, featuring both respiratory and extra-respiratory symptoms. | 2020-06-16 |
| 32544034 | A majority of patients (20/37, 54%) had intracerebral hemorrhagic lesions with a more severe clinical presentation: higher admission rate in intensive care units, 20/20 patients, 100% versus 12/17 patients, 71%, p=0.01; development of the acute respiratory distress syndrome in 20/20 patients, 100% versus 11/17 patients, 65%, p=0.005. | 2020-06-23 |
| 32544071 | Yet, knowledge on symptoms prognostic of COVID-19 severity is lacking. […] The objective of our study was to identify symptoms prognostic of COVID-19 infection severity. […] We analyzed documented symptoms including fever, cough, fatigue, expectoration, sore throat, chest distress, headache, diarrhea, rhinorrhea, stuffy nose, nausea, vomiting, muscle or joint ache, shortness of breath, and their associations with patient severity using a case series including 655 confirmed cases from January 23 to February 5, 2020 in Henan province, China. […] We also analyzed the influence of individual characteristics including age, gender and comorbidities on symptoms with prognostic value. […] ‘Fatigue’ (95%CI=0.141-0.334, P<.001), ‘Expectoration’ (95%CI=0.107-0.305, P<.001) and ‘Stuffy nose’ (95%CI=-0.499- -0.082, P=0.006) were identified as the prognostic symptoms of COVID-19 patients from the multivariate analysis. | 2020-06-16 |
| 32544099 | The data of clinical features, laboratory tests, immunological tests, radiological findings, and outcomes were collected. […] Receiver operator characteristic (ROC) curves and survival curves were plotted to evaluate the clinical usefulness. | 2020-06-16 |
| 32544103 | Incorporating innovations such as telemedicine, used under duress during the pandemic, could alter educational and clinical approaches to create something better for students, residents, and patients. | 2020-06-25 |
| 32544146 | To inform the current coronavirus disease 2019 (COVID-19) outbreak, we conducted a systematic literature review of case reports of Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, during pregnancy and summarized clinical presentation, course of illness, and pregnancy and neonatal outcomes. […] Clinical presentation and course of illness ranged from asymptomatic to severe fatal disease, similar to the general population of patients. […] Data from case reports of SARS-CoV, MERS-CoV, and SAR-CoV-2 infections during pregnancy are limited, but they may guide early public health actions and clinical decision-making for COVID-19 until more rigorous and systematically collected data are available. | 2020-06-16 |
| 32544150 | The paper concludes with some recommendations regarding how to reach an agreement about rationing criteria and about their implementation in clinical practice. | 2020-06-22 |
| 32544155 | The clinical and epidemiological characteristics of adult patients have been documented recently. […] We describe the clinical and epidemiological characteristics of pediatric patients to provide valuable insight into the early diagnosis and assessment of COVID-19 in children. […] Clinical and epidemiological characteristics were analyzed on the basis of demographic data, medical history, laboratory tests, radiological findings, and treatment information. […] The most common initial symptoms were fever (76%) and cough (62%). […] Lesions in lobules still existed in 24 (among 32 patients with lesions; 75%) patients that were discharged, although the main symptoms disappeared a few days after treatment. […] Our data systemically presented the clinical and epidemiological features, as well as the outcomes, of pediatric patients with COVID-19. | 2020-06-25 |
| 32544281 | Moreover, it is almost unknown to discriminate COVID-19 and nucleic acid negative patients based on clinical features in the fever clinics. […] The epidemiological and clinical characteristics were compared between COVID-19 and nucleic acid negative patients. | 2020-06-16 |
| 32544429 | We also highlighted possible therapies and their mechanism of action followed by clinical manifestation. | 2020-06-26 |
| 32544492 | Key points include acting quickly, identifying and engaging key stakeholders early, providing accurate information, prioritizing employee safety and mental health, promoting a fully integrated clinical response, developing surge plans, preparing for ethical dilemmas, and having a cogent exit strategy for post disaster recovery. | 2020-06-19 |
| 32544543 | Clinical trial recruitment was temporary halted in many centres to reduce patients and healthcare workers’ potential exposure to the virus. | 2020-06-19 |
| 32544566 | Conjunctival signs and symptoms are observed in a subset of patients with COVID-19, and SARS-CoV-2 has been detected in tears, raising concerns regarding the eye both as a portal of entry and carrier of the virus. | 2020-06-25 |
| 32544611 | Children, because of having an immature immune system, are usually more prone than the adults to the microbial infections and have more severe symptoms, which is especially true for the newborns, and very young children. […] However, the review of clinical data from the current COVID-19 pandemic indicates otherwise. | 2020-06-27 |
| 32544622 | Clinical characteristics and ECG variables were manually abstracted from the electronic health record and first ECG. […] In a multivariable logistic regression that included age, ECG, and clinical characteristics, the presence of one or more atrial premature contractions (APC)s (odds ratio (OR)=2.57, 95% confidence interval (CI) 1.23-5.36, p=0.01), a right bundle branch block (RBBB) or intraventricular block (IVB) (OR=2.61, 95% CI 1.32-5.18, p=0.002), ischemic T-wave inversion (OR=3.49, 95% CI 1.56-7.80, p=0.002), and nonspecific repolarization (OR=2.31, 95% CI 1.27-4.21, p=0.006) increased the odds of death. | 2020-06-26 |
| 32544802 | We describe the ongoing COVID-19 therapies that should be known by oncologists and highlight the potential interactions with antineoplastic drugs, commonly used in clinical practice. […] Future clinical trials are needed to better understand the interactions between different drugs in the context of COVID-19 pandemic. | 2020-06-25 |
| 32544867 | Demographic data, clinical symptoms, virological clearance, and imaging findings recorded during the study. […] Although other symptoms decreased gradually. | 2020-06-23 |
| 32544879 | We further propose adaptations to established clinical processes and practices across the different specialties involved in breast oncology, with references to the relevant evidence base or expert consensus guidelines. | 2020-06-16 |
| 32545378 | We cannot rule out potential worsening of the clinical conditions of pregnant women infected with SARS-CoV-2, whether the infection is associated with comorbidities or not, due to the occurrence of respiratory disorders, cardiac rhythm disturbances, and acid-base imbalance, among others. | 2020-06-25 |
| 32545556 | The present review summarizes Chinese observations and compares these with the latest European Society for Clinical Nutrition and Metabolism guidelines. | 2020-06-24 |
| 32545714 | Without this understanding, it is challenging to discover a successful treatment to be approved for clinical use. | 2020-06-26 |
| 32546000 | In less than 4 weeks after it was first announced on April 3, 2020, AHA’s COVID-19 CVD Registry powered by Get With The Guidelines® (GWTG) received its first clinical records. Methods and Results: Participating hospitals are enrolling consecutive hospitalized patients with active COVID-19 disease, regardless of CVD status. […] This hospital quality improvement program will allow participating hospitals and health systems to evaluate patient-level data including mortality rates, intensive care unit (ICU) bed days, and ventilator days from individual review of electronic medical records of sequential adult patients with active COVID-19 infection. | 2020-06-17 |
| 32546018 | It is recommended that these proteases, inhibitors, and antibodies could be a good therapeutic option in drug discovery to control the newly emerged coronavirus.HighlightsCOVID-19 has more than 79.5% identical sequence to SARS-CoV and a 96% identical sequence of the whole genome of bat coronaviruses.Acute respiratory distress syndrome (ARDS), renal failure, and septic shock are the possible clinical symptoms associated with COVID-19. […] The initial clinical trials on hydroquinone in combination with azithromycin showed an admirable result in the reduction of COVID-19. | 2020-06-25 |
| 32546029 | He was subsequently treated with tocilizumab with marked clinical improvement and a decrease in acute phase reactants within 48 h. Discussion & conclusion: This case demonstrates the effective use of tocilizumab in the treatment of COVID-19 and suggests the superiority of tocilizumab over lenzilumab in the management of this cytokine-mediated syndrome. | 2020-06-27 |
| 32546047 | While the potential therapeutic utility of angiotensin-converting enzyme 2 (ACE2) is well established, the clinical development of ACE2 drugs has been limited, likely due in part to the short half-life of the protein. […] Clinical investigation of Ig-like ACE2 fusion proteins as COVID-19 interventions is thus warranted. | 2020-06-17 |
| 32546125 | Based on this accumulating experimental and clinical evidence, we finally provide the research design for a double-blind placebo-controlled randomized clinical trial including severely affected patients, which is planned to start shortly. | 2020-06-23 |
| 32546365 | Reverse transcriptase-polymerase chain reaction (RT-PCR) results and clinical features of COVID-19 were assessed to determine if COVID-19 was clinically suspected at the time of CT referral. […] After correlation with clinical features and RT-PCR 8/172 (4.7%) were defined as COVID-19 positive, of which only 1/172 (0.6%) was clinically unsuspected of COVID-19 at the time of CT referral. | 2020-06-19 |
| 32546368 | Using the Real-time Polymerase Chain Reaction techniques for SARS-CoV-2 nucleic acids, the possible presence of this germ in vaginal discharge and amniotic fluid was investigated in four pregnant Caucasian patients affected by mild acute symptoms of COVID-19 during the second trimester of pregnancy. | 2020-06-19 |
| 32546387 | Our plan was guided by the following principles: protecting the workforce while providing essential clinical care; maintaining continuity of education and research; and promoting social distancing while minimizing the impact on team psychosocial well-being. | 2020-06-19 |
| 32546437 | To identify the clinical characteristics and outcomes of hospitalized patients with COVID-19 in Oman. […] The most common presenting symptoms at onset of illness were fever (84%; n=53), cough (75%; n=47) and shortness of breaths (59%; n=37). | 2020-06-23 |
| 32546439 | Epidemiological, clinical, laboratory, and radiological characteristics of the children were analyzed. […] Among ten patients, five (50%) were asymptomatic and five (50%) showed mild symptoms of respiratory illness. | 2020-06-19 |
| 32546454 | During a pandemic, narrowing ethics into silos such as clinical and public health does not help the cause of ethics, which often gets neglected in desperate times. | 2020-06-17 |
| 32546458 | Several ongoing large scale clinical trials are focused on the same research questions, the preliminary results of which are still awaited. | 2020-06-17 |
| 32546461 | The key argument is for countries to mainstream clinical ethics considerations for care of patients with Covid-19 as well as “non-Covid-19” illnesses. […] Keywords: SARS-CoV2, Covid 19, clinical ethics, duty to care, allocation of scarce resources, moral distress. | 2020-06-17 |
| 32546559 | Anticipatory prescribing (AP) of injectable medications in advance of clinical need is established practice in community end-of-life care. […] Clinical contact and patient assessment were more often remote via telephone or video (63%). […] The extent to which these are implemented and their clinical efficacy need further examination. | 2020-06-17 |
| 32546589 | It has been proven that converting large-scale public venues such as stadiums and exhibition centres into Fangcang shelter hospitals, which serve as hospitals for isolation, treatment and disease monitoring of patients with mild symptoms, is the most effective way to control virus transmission and reduce mortality. | 2020-06-25 |
| 32546593 | The extent to which clinical and demographic factors moderate this relationship is unclear, though signals are emerging that link higher BMI and higher HbA1c to worse outcomes in PWD with COVID-19. | 2020-06-17 |
| 32546598 | We aim to further evaluate the clinical characteristics of COVID-19 in patients with systemic autoimmune diseases (AIDs). […] We retrospectively collected and analysed information on epidemiology of 1255 inpatients and additional clinical characteristics of patients with systemic AIDs. […] The lower proportion of COVID-19 in patients with systemic AIDs needs more high-quality human clinical trials and in-depth mechanism researches. | 2020-06-27 |
| 32546655 | Further studies are needed to clarify the frequency and nature of COVID-19-related CNS damage, and its relation to both clinically-defined CNS events such as hypoxic and ischemic events and to mechanisms more closely linked to systemic SARS-CoV-2 infection and consequent immune activation, and also to evaluate the clinical utility of monitoring plasma NfL and GFAp in management of this group of patients. | 2020-06-17 |
| 32546678 | This study aimed to investigate the clinical and demographic characteristics of cluster cases and sporadic cases of COVID-19 in 141 patients in the main district of Chongqing during one month, between January and February 2020. […] Demographic and clinical characteristics were compared between the two study groups and included the presence of comorbidities, the presenting symptoms, chest computed tomography (CT) imaging findings, and laboratory findings. […] CONCLUSIONS There were demographic and clinical differences between cluster cases and sporadic cases of COVID-19 in the main district of Chongqing during the month between January to February 2020. | 2020-06-23 |
| 32546764 | In this study, we report the generation of clinical-grade human embryonic stem cells (hESCs)-derived immunity- and matrix-regulatory cells (IMRCs) produced under good manufacturing practice requirements, that can treat lung injury and fibrosis in vivo. […] In light of public health crises involving pneumonia, acute lung injury and acute respiratory distress syndrome, our findings suggest that IMRCs are ready for clinical trials on lung disorders. | 2020-06-28 |
| 32546824 | Age disparities in observed cases could be explained by children having lower susceptibility to infection, lower propensity to show clinical symptoms or both. […] We estimate that susceptibility to infection in individuals under 20 years of age is approximately half that of adults aged over 20 years, and that clinical symptoms manifest in 21% (95% credible interval: 12-31%) of infections in 10- to 19-year-olds, rising to 69% (57-82%) of infections in people aged over 70 years. […] Accordingly, we find that interventions aimed at children might have a relatively small impact on reducing SARS-CoV-2 transmission, particularly if the transmissibility of subclinical infections is low. […] Our age-specific clinical fraction and susceptibility estimates have implications for the expected global burden of COVID-19, as a result of demographic differences across settings. […] In countries with younger population structures-such as many low-income countries-the expected per capita incidence of clinical cases would be lower than in countries with older population structures, although it is likely that comorbidities in low-income countries will also influence disease severity. | 2020-06-17 |
| 32547309 | Objective: To analyze the blood test indicators of patients after infection of COVID-19 in Chongqing and analyze the clinical indicators of 8 patients with diarrhea. Materials and Methods: From January 26, 2019 to February 13, 2020, 70 patients diagnosed with 2019-nCoV according to the World Health Organization interim guidance for NCP and divided into diarrhea and non-diarrhea groups. | 2020-06-22 |
| 32547323 | Rationale: Up to date, the exploration of clinical features in severe COVID-19 patients were mostly from the same center in Wuhan, China. […] The clinical data in other centers is limited. […] This study aims to explore the feasible parameters which could be used in clinical practice to predict the prognosis in hospitalized patients with severe coronavirus disease-19 (COVID-19). […] Clinical information was collected and analyzed for the following objectives: 1. | 2020-06-22 |
| 32547383 | Coronavirus disease-19 is a respiratory viral disease that commonly presents with mild symptoms. | 2020-06-19 |
| 32547625 | Numerous clinical trials have been initiated to identify an effective treatment. […] Although remdesivir performed well in preclinical studies, it did not meet efficacy endpoints in a randomized trial conducted during an Ebola outbreak. […] Remdesivir holds promise for treating COVID-19 based on in vitro activity against SARS-CoV-2, uncontrolled clinical reports, and limited data from randomized trials. […] We then summarize preclinical and clinical studies of remdesivir for Ebola and COVID-19. | 2020-06-19 |
| 32547882 | Both the clinical sensitivity and specificity of this assay were 100%. | 2020-06-19 |
| 32547932 | Patients with coronavirus disease 2019 (COVID-19) predominantly present with the pulmonary symptoms such as fever, cough, and shortness of breath. […] We present a case of an 83 years old patient with COVID-19 who presented with only gastrointestinal symptoms without respiratory complaints. | 2020-06-19 |
| 32548163 | What are the clinical features of this disease? […] What is the clinical diagnosis and how should such patients be treated? […] As a clinician, mastery of the clinical characteristics, basic diagnosis, and treatment methods of COVID-19 are required to provide help to patients. […] The main clinical symptoms were dry cough, fatigue, and fever. […] On February 2, symptoms decreased, various indicators improved, and pulmonary inflammation was obviously reduced. […] We report a typical case of COVID-19, analyze its clinical characteristics, summarize its clinical diagnosis and treatment experience, and provide a reference for clinical colleagues. | 2020-06-19 |
| 32548166 | The clinical symptoms and prognosis of COVID-19 in pediatric patients may be different from those in adult patients, and the fecal-oral transmission of SARS-CoV-2 should be considered. | 2020-06-19 |
| 32548209 | Studies that reported clinical data on olfactory disturbances in COVID-19 patients were analyzed. […] Among COVID-19 patients, 12 of 18 (67%) reported olfactory symptoms and OD was confirmed in 6 patients by BTT and SIT. […] Olfactory dysfunction persisted in 2 patients despite clinical recovery. | 2020-06-19 |
| 32548551 | In preclinical studies, activated protein C (APC) provides negative feedback downregulation of excessive inflammation and thrombin generation, attenuates damage caused by ischemia-reperfusion in many organs including lungs, and reduces death caused by bacterial pneumonia. […] Preclinical studies show that its direct cell-signaling actions mediate anti-inflammatory and anti-apoptotic actions, mortality reduction for pneumonia, and beneficial actions for ischemia-reperfusion injury. […] Because of its broad spectrum of homeostatic effects in preclinical studies, we speculate that 3K3A-APC merits consideration for clinical trial studies in appropriately chosen, seriously ill patients with COVID-19. | 2020-06-19 |
| 32548601 | Clinical and epidemiological studies suggest that human-to-human transmission of coronavirus disease 2019 (COVID-19) most frequently occurs through virus-laden respiratory droplets discharged from infected individuals while coughing and sneezing. | 2020-06-18 |
| 32548613 | Healthcare-acquired infection has been reported in similar epidemics, but there are limited data on the prevalence of COVID-19 among HCWs and their associated clinical outcomes in the United States. […] Using data from these testing centers, we report the prevalence of SARS-CoV-2 infection among symptomatic employees and describe the clinical characteristics and outcomes among employees with COVID-19. | 2020-06-17 |
| 32548628 | We calculated the point prevalence of SARS-CoV-2 and assessed symptom onset over 30-day follow-up to determine: 1) the proportion of cases who were symptomatic, pre-symptomatic, and asymptomatic and 2) incidence of symptoms among those who tested negative. […] Nineteen (58%) had symptoms at the time of testing, 1 (3%) developed symptoms over follow-up, and 13 (39%) remained asymptomatic. […] Thirty-five residents who tested negative on March 15 developed symptoms over follow-up; of these, 3 were re-tested and 2 were positive. | 2020-06-17 |
| 32548750 | We performed a review to describe, in particular, the origin and the diffusion of COVID-19 in Italy, underlying how the geographical circulation has been heterogeneous and the importance of pathophysiology in the involvement of cardiovascular and neurological clinical manifestations. | 2020-06-19 |
| 32548787 | Telemedicine is a global term used to describe any use of telecommunication systems to deliver healthcare from a distance and encompasses a range of different scenarios from remote clinical data transfer to remote clinician-patient interactions. […] There is an urgent need for further health service evaluation and research to address the impact of remote healthcare delivery during COVID-19 outbreak on patient care, and in the longer term, to identify acceptability and cost- and clinical-effectiveness of remote care delivery on outcomes of relevance to people living with osteoporosis. | 2020-06-19 |
| 32548994 | The variety of clinical and care scenarios we are observing in Italy depends on the region, the organization of local services and the hospital involved. […] The present document aims at defining the state of the art of CR during COVID-19 pandemic, through the description of the clinical and management scenarios frequently observed during this period and the exploration of the future frontiers in the management of cardiac rehabilitation programs after the COVID-19 outbreak. | 2020-06-24 |
| 32548995 | Moreover, it also intends to review the clinical guidelines to be adopted in practice of endocrinology in this trying time. | 2020-06-17 |
| 32549020 | The Norwegian Surveillance System for Communicable Diseases (MSIS) is based on reporting of cases of 72 mandatory notifiable diseases by clinical microbiological laboratories and diagnosing physicians. | 2020-06-25 |
| 32549025 | The routine nasopharyngeal swab for PCR was negative at days 5 and 7 after onset of symptoms. […] It also emphasises the importance of including other clinical measures before discontinuation of isolation. | 2020-06-25 |
| 32549038 | An informal survey of 65 pediatric emergency department leaders in North America-from 30 U.S. states and 4 Canadian provinces-revealed changes in operations, infrastructure, staffing, and clinical care that were undertaken as a result of the COVID-19 pandemic. […] The changes identified by the survey respondents were driven by reductions in pediatric patient volumes, a surge of adult patients, clinical considerations related to containment of infection, and financial factors. | 2020-06-18 |
| 32549071 | The patients presented clinical symptoms of dry cough, fever, dyspnea, and bilateral lung infiltrates on imaging. | 2020-06-17 |
| 32549072 | Although fever can occur along with urological infections, it is actually one of the commonest symptoms of COVID-19; urologists must always maintain a high index of suspicion in their clinical practices. | 2020-06-19 |
| 32549073 | We conducted a review of current literature related to surgical and clinical management of patients during COVID-19 crisis paying special attention to oncological ones and especially those suffering from PCa. | 2020-06-17 |
| 32549077 | A non-systematic review of available literature on the management of urological malignancies during the COVID-19 pandemic was performed to summarize recommendations to improve the diagnosis and treatment of urological cancers during and after the contingence, including clinical and research aspects. | 2020-06-17 |
| 32549122 | Objectives The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Task Force on COVID-19 conducted a global survey to understand how biochemistry laboratories manage the operational challenges during the coronavirus disease 2019 (COVID-19) pandemic. […] Conclusions The restriction of tests and services may have undesirable clinical consequences as clinicians are deprived of important information to deliver appropriate care to their patients. | 2020-06-18 |
| 32549123 | Methods An electronic survey was developed to record the general characteristics of the laboratory, as well as the pre-analytical, analytical, post-analytical and operational practices of biochemistry laboratories that are managing clinical samples of patients with COVID-19. | 2020-06-18 |
| 32549293 | In light of the favorable outcomes of few small, non-randomized clinical studies, the Food and Drug Administration (FDA) has issued an Emergency Use Authorization (EUA) to Hydroxychloroquine (HCQ) for hospitalized coronavirus disease 2019 (COVID-19) patients. […] In fact, subsequent clinical studies with COVID-19 and HCQ have reported limited efficacy and poor clinical benefits. […] Unfortunately, a robust clinical trial for its effectiveness is not feasible at this emergency. | 2020-06-18 |
| 32549334 | Therefore, this review aims to provide insight on the pathogenesis and the transmission dynamics of CoVID-19 along with pharmacological and non-pharmacological intervention strategies to mitigate the clinical manifestation of this virus. […] Although the clinical manifestation of symptoms is mild in majority of the virus-inflicted population, critical patients may present with pneumonia and acute respiratory distress syndrome, exacerbated by pre-existing comorbidities, eventually leading to death. […] While effective coronavirus disease (CoVID-19)-specific vaccines and drugs are under clinical trials, several pharmacological and non-pharmacological interventions have been adapted to manage symptoms and curtail the effect of the virus to prevent increasing morbidity and mortality. […] Given the clinical insights into CoVID-19 and the challenges presented in this review for the U.S. rural population, mitigation strategies should be designed accordingly to minimize the morbidity and mortality of this contagion. | 2020-06-25 |
| 32549526 | There are limited data on the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in respiratory specimens after resolution of coronavirus disease 2019 (COVID-19)-associated symptoms/signs. […] We determined duration of SARS-CoV-2 virus shedding in symptomatic patients after remission of symptoms. […] After resolution of symptoms/signs, SARS-CoV-2 RNA was detected for median (range) of 26 days (9 to 48). […] This case represents the longest duration of SARS-CoV-2 detection, and highlights the need for long-term follow up of COVID-19 patients despite resolution of symptoms to confirm SARS-CoV-2 clearance. | 2020-06-23 |
| 32549531 | The recent Sars-Cov-2 pandemic (COVID-19) has led to growing research to explain the poor clinical prognosis in some patients. […] While early observational studies highlighted the role of the virus in lung failure, in a second moment thrombosis emerged as a possible explanation of the worse clinical course in some patients. […] However, it is our opinion that an early use, even at home at the beginning of the disease, could improve the clinical course. | 2020-06-18 |
| 32549532 | We retrospectively reviewed the clinical records of patients referred to the ED of a University Hospital in Northern Italy from 1st March to 13th April 2020. | 2020-06-18 |
| 32549692 | Hip fracture patients represent a high-risk population for severe COVID-19 symptoms, as they are generally older with multiple medical comorbidities. […] Clinical characteristics and early postoperative outcomes were reported. […] Eight out of the 10 COVID-positive hip fracture patients in our series were asymptomatic on admission with no clinical signs or symptoms of COVID-19 infection. | 2020-06-19 |
| 32549983 | Subjective reporting on respiratory symptoms was also analyzed. […] Subjects with LMC mask use reported higher comfortability (p<0.05), breathability (p<0.05), and lower allergy symptoms (p<0.05). | 2020-06-19 |
| 32550035 | The patient was discharged from hospital in relief of symptoms on February 9th. Conclusion. | 2020-06-19 |
| 32550054 | This virus is a zoonotic pathogen seen with a wide range of clinical features from asymptomatic state to intensive care in humans. | 2020-06-19 |
| 32550056 | We searched using PubMed and Google Scholar using keywords such as COVID-19, coronavirus, and their combination with pathological findings, clinical features, management, and treatment to search for relevant published literature. […] Most of the COVID-19 affected patients have mild pneumonia symptoms, and those with severe disease have comorbidities. […] Patients with mild symptoms should self-quarantine, whereas those with severe acute respiratory distress syndrome (ARDS) are treated in the hospital. […] The symptoms shown by patients are very mild and self-limiting. | 2020-06-19 |
| 32550069 | This review is focused on literature, research, and expert clinical judgments published in 2020 with a few references to articles published earlier. […] The review introduces the interim guidelines of the International Society of Thrombosis and Haemostasis (ISTH) for management of COVID-19-induced coagulopathy, discusses the efficacy of these guidelines in clinical settings, and summarizes the response of the scientific community to these guidelines and their clinical implications. | 2020-06-19 |
| 32550070 | At the clinical presentation, they reported fever and dry cough; in six out of 25 cases, dyspnea was also reported (24%). […] Although CT represents a fundamental diagnostic tool because of its sensitivity, it still needs to be integrated with clinical data to achieve the best clinical management. | 2020-06-19 |
| 32550090 | Medical records of these patients were reviewed using the EPIC electronic health record system. […] Demographic, clinical, laboratory, and treatment data were reviewed against periods of bradycardia in each patient. | 2020-06-19 |
| 32550127 | This report describes the clinical course and management of the first severe case that required intensive care. […] This case highlights the importance of epidemiological surveillance and active case finding to detect and diagnose the case at an early stage for appropriate clinical management for positive outcomes in high risk groups. | 2020-06-19 |
| 32550139 | From February 10 to March 10, 2020, 125 COVID-19 patients (age: 16-67 years, 63 males) ready for discharge, with two consecutive negative reverse transcription-polymerase chain reaction (RT-PCR) and no clinical symptoms for more than 3 days, were included. | 2020-06-19 |
| 32550140 | This study aimed to analyze the clinical and chest CT features of 15 COVID-19 patients with positive reverse transcription-polymerase chain reaction (RT-PCR) retest results after discharge. […] Clinical manifestations, laboratory data, and chest CT images were retrospectively reviewed and analyzed. […] The most common symptoms at Covid-19COVID-19 initial onset were fever (12/15, 80%) and cough (11/15, 73.3%). […] At re-admission, all patients had normal clinical results except five (33.3%) patients had increased CRP compared with first discharging, two (13.3%) patients had increased neutrophils count, and one (6.6%) had increased CRP. […] There may be no specific clinical characteristics to predict the re-detectability of the virus. | 2020-06-19 |
| 32550256 | Typical clinical manifestations include fever, cough and dyspnea after an incubation period of 2-14 days. […] Here, we review the pertinent clinical findings and the current published data describing chest CT findings in COVID-19 pneumonia, the diagnostic performance of CT for diagnosis, including differential diagnosis, as well the evolving role of imaging in this disease. | 2020-06-19 |
| 32550259 | Although this infective disease is mostly characterized by respiratory tract symptoms, increasing numbers of evidence had shown considerable amounts of patients with cardiovascular involvements and these were associated with higher mortality among COVID-19 patients. | 2020-06-23 |
| 32550285 | It is vital that the vulnerable and immunocompromised members of our workforce are protected, which may mean that they do not go into clinical areas. | 2020-06-19 |
| 32550286 | The comprehensive hospital agile preparedness (CHAPs) tool provides clinical planners with six key domains to consider that frequently create resource strain during COVID-19; it also allows local planners to identify issues unique to their hospital, system or region. | 2020-06-19 |
| 32550287 | In response to this unprecedented burden on acute care services, stroke clinicians are having to reconfigure existing clinical pathways both within and between hospitals. […] Incorporating artificial intelligence and digital communication support into clinical pathways offers an opportunity to mitigate the disruption to acute stroke care. | 2020-06-19 |
| 32550647 | This article discusses the concept of medical sacrifice and personal risk, and how healthcare workers can apply these concepts when working outside their comfort zones, while remaining within the limits of their clinical competence. | 2020-06-19 |
| 32550702 | little is known on the risk factors, clinical presentation, therapeutic protocols, and outcomes of kidney transplantation recipients (KTRs) who become infected by SARS-CoV-2. to provide an updated view regarding the early experience obtained from the management of KTRs with COVID-19. […] SARS-CoV-2 symptoms in KTRs are similar to that observed for the general population, being fever and cough the most frequently observed. […] Mild-to-moderate symptomatic KTRs can be managed in an outpatient setting, while patients exhibiting severe symptoms must be addmited to hospital. […] More rapid clinical progression, and higher complication and death rates have been observed for hospitalized KTRs, requiring hemodyalisis or ventilatory support. | 2020-06-18 |
| 32550704 | As urologists, we must be involved in these new standards, since without an effective vaccine the risk of contagion is high; thus, the purpose of this review is to have orientation on the measures urologists should take in their everyday clinical practice. | 2020-06-18 |
| 32550705 | Randomized clinical trials and high-quality evidence, even in the middle of a pandemic, are needed. | 2020-06-18 |
| 32550783 | It is reported that a variety of symptoms and syndromes such as headache, dizziness, confusion, ataxia, epilepsy, ischemic stroke, neuropathic pain and myopathy are common especially in more severe COVID-19 patients. […] It is thought that SARS-CoV-2 may cause neurological symptoms through direct or indirect mechanisms. | 2020-06-20 |
| 32550953 | Decisions on health-care resource allocation should take into consideration the preferences of the patient and their goals of care, as well as patient factors like the Clinical Frailty Scale score based on their status two weeks before the onset of symptoms. […] A threshold of 5 or greater on the Clinical Frailty Scale is recommended if this scale is utilized in helping to decide on access to limited health-care resources such as admission to a critical care unit and/or intubation during the COVID-19 pandemic. | 2020-06-20 |
| 32550954 | The clinical presentation in older adults with severe illness, in the experience from geriatricians in Lombardy, is described as quite sudden; patients can develop severe hypoxemia with the need of ventilation support in few hours. | 2020-06-20 |
| 32551102 | Like other institutes and industries in the country, clinical laboratories were succumbed to a variety of challenges. […] This article is based on the experience and adapted workflow measures from the Clinical Chemistry laboratory at the Aga Khan University Hospital (AKUH), Karachi, which serves as a national referral center with its widespread network of satellite laboratories and phlebotomy centers across the country. | 2020-06-20 |
| 32551214 | Fever, respiratory symptoms and hypoxemia significantly improved over the next 2 weeks, but the patient developed abdominal pain, nausea, and low-grade fever. | 2020-06-20 |
| 32551443 | The aim of this review is to highlight the key recommendations related to obstetric anaesthesia from scientific bodies in the United Kingdom and United States and to summarize recently developed and implemented clinical pathways for care of obstetric patients - specifically those requiring urgent general anaesthesia for caesarean section within a large maternity unit in London. | 2020-06-20 |
| 32551453 | The main steps for diagnosis of COVID-19 are investigation of symptoms, recollection of travel and physical contact history, and testing using the real time polymerase chain reaction (RT-PCR) test. | 2020-06-20 |
| 32551754 | How a system defines trauma will drive its administrative policies, research, and clinical services. | 2020-06-19 |
| 32551767 | This commentary serves to tie existing literature on mental health and COVID-19 to the clinical experiences of a psychologist working in the Canadian hospital sector. | 2020-06-19 |
| 32551771 | This article contains clinical observations and reflections from two practicing psychologists regarding the impact of the COVID-19 pandemic and associated social conditions on clients with posttraumatic stress disorder. | 2020-06-19 |
| 32551792 | The purpose of this article is to overview the history, epidemiology, clinical characteristics, diagnosis, and treatment of COVID 2019 reported in recently published studies. | 2020-06-23 |
| 32551855 | Gene-Eden-VIR and Novirin are natural, broad-spectrum, antiviral treatments proven to be safe and effective in several clinical studies. […] Next, we are planning to conduct a clinical study with users of the treatments to test the effects of Gene-Eden-VIR/Novirin on individuals at risk and those infected with the virus. | 2020-06-27 |
| 32551862 | The present article reviews the molecular factors shared by coronaviruses infection and pulmonary vasculature defects, and the clinical relevance of pulmonary vascular alterations in the context of COVID-19. | 2020-06-19 |
| 32552229 | Although universal droplet precautions are now recommended in most healthcare settings, some clinical situations require more stringent infection control measures. | 2020-06-19 |
| 32552415 | Typical presentations of Coronavirus Disease 2019 (COVID19) including respiratory symptoms (cough, respiratory distress and hypoxia), fever and dyspnea are considered main symptoms in adults, but atypical presentation children could be a diagnostic challenge We report three children whose initial presentation was gastrointestinal, and in whom COVID-19 infection was found, concluding that cases of acute appendicitis, mesenteric adenitis and flank tenderness may mask and infection with this virus, which should therefore be investigated. | 2020-06-19 |
| 32552464 | Clinical and research exchanges, carried out under the auspices of the IFMSA, allow all the students to discover the health care and medical education systems of another country in a different sociocultural environment. | 2020-06-19 |
| 32552642 | These CQ analogues have shown potential efficacy to inhibit 2019-nCoV in vitro that lead to focus in several future clinical trials. | 2020-06-19 |
| 32552659 | These have been made possible with an early setup of an operational command and control structure within the ED, managing manpower, logistics, operations, communication and information management and liaison with other clinical departments. | 2020-06-21 |
| 32552751 | Although the number of infected cases is increasing, information about its clinical characteristics in the Middle East, especially in Iran, a country which is considered to be one of the most important focal points of the disease in the world, is lacking. […] To date, there is no available literature on the clinical data on COVID-19 patients in Iran. […] The most common symptoms at onset were fatigue (75: 66.4%), cough (73: 64.6%), and fever (67: 59.3%). […] Evaluating the clinical data of COVID-19 patients and finding the source of infection and studying the behavior of the disease is crucial for understanding the pandemic. | 2020-06-22 |
| 32552792 | Our findings suggest that neurologic symptoms such as encephalopathy and seizures may be the initial presentation of COVID-19. | 2020-06-24 |
| 32552794 | Clinical diagnosis could be a good complement to the method of confirmation at that time. | 2020-06-28 |
| 32552865 | Clinical and laboratory features of CAC overlap somewhat with a hemophagocytic syndrome, antiphospholipid syndrome, and thrombotic microangiopathy. | 2020-06-22 |
| 32553046 | Surveillance of such parasites is dependent on identifying false-negative RDT results among suspected malaria cases, a task made more challenging during the current pandemic because of the overlap of symptoms between malaria and COVID-19, particularly in areas of low malaria transmission. | 2020-06-19 |
| 32553051 | Public Health England’s Second Generation Surveillance System is a centralized microbiology database covering English clinical diagnostics laboratories that provides national surveillance of legally notifiable infections, bacterial isolations and antimicrobial resistance. | 2020-06-19 |
| 32553059 | On both farms, at least one worker had coronavirus disease-associated symptoms before the outbreak. | 2020-06-26 |
| 32553062 | A suspected COVID-19 case was defined as a passenger or crew member who developed a fever or respiratory symptoms, and a confirmed COVID-19 case had laboratory-confirmation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. | 2020-06-23 |
| 32553064 | Overall, 120 contacts (9.0%) reported symptoms which required referral for testing and 35 (2.6%) tested positive for COVID-19. […] Non-response was high (n = 2,121; 17.1%) and this required substantial clinical and administrative resources for follow-up. | 2020-06-26 |
| 32553350 | CRISPR assay diagnostic results obtained nasal swab samples of individuals with suspected COVID-19 cases were comparable to paired results from a CDC-approved quantitative RT-PCR (RT-qPCR) assay performed in a state testing lab, and superior to those produced by same assay in a clinical lab, where the RT-qPCR assay exhibited multiple invalid or inconclusive results. | 2020-06-25 |
| 32553456 | Clinical research paper LEVEL OF EVIDENCE: Level V. | 2020-06-22 |
| 32553536 | For tocilizumab-treated patients, a pre/post analyses of clinical response, biomarkers and safety outcomes was assessed. | 2020-06-19 |
| 32553562 | Olfactory or gustatory dysfunction is reported as one of the symptoms worldwide. […] As reported so far, different clinical features have been reported according to outbreak sites and gender; most of the patients, who complained of anosmia or hyposmia, were Europeans. […] Up to date, a lot of reports have shown that olfactory dysfunction is related to viral infections but no exact mechanism, clinical course, and definite treatment have been discovered, which is also same in COVID-19. […] Considering severe respiratory complications and immunocompromised state of COVID-19, the use of steroid should be limited and cautious because we do not have enough data to support the usage of steroid to treat olfactory dysfunction in the clinical course of COVID-19. […] In the days of pandemic COVID-19, we should keep in mind that olfactory dysfunctions, even without other upper respiratory infection or otolaryngologic symptoms, might be the early signs of COVID-19. | 2020-06-22 |
| 32553720 | Here, we report three clusters of individuals that were exposed to diverse inoculi in Madrid and overall developed divrgent clinical forms of COVID-19. | 2020-06-21 |
| 32553861 | To assess clinical characteristics and outcomes of SARS-CoV-2 associated multisystem inflammatory syndrome in children (MIS-C). […] Demographic and clinical data were collected. […] Fever (93%) and vomiting (69%) were the most common presenting symptoms. […] Rapid, complete clinical and myocardial recovery was almost universal. | 2020-06-22 |
| 32553907 | Data of demographic, clinical characteristics, laboratory tests, treatments, and clinical outcomes were collected. | 2020-06-21 |
| 32553908 | This study aimed to report the maternal characteristics and clinical outcomes of pregnant women with COVID-19 disease. | 2020-06-21 |
| 32554082 | We assessed the clinical characteristics and comorbidities in asthmatic and non-asthmatic COVID-19 patients. […] Medical records of patients with COVID-19 were searched by a computer algorithm (March 1-April 15, 2020), and chart review was used to validate the diagnosis of asthma and medications prescribed for asthma. […] Demographics and clinical features were characterized. | 2020-06-21 |
| 32554284 | Ten patients with a diagnosis of relapsing-remitting MS were phoned and asked about symptoms suggestive and COVID-19 using a semi-structured questionnaire. […] Two patients (20%) developed symptoms highly suggestive of COVID-19. […] Patients with COVID-19 symptoms had longer clinical course of MS. […] Conversely, we did not find statistically significant differences regarding age, EDSS, last lymphocyte count, and months since the last dose of alemtuzumab administered between patients having or not symptoms of COVID-19. […] Our data suggest that patients receiving alemtuzumab showed very mild symptoms of COVID-19. | 2020-06-26 |
| 32554285 | After an incubation period of 3-14 days, the infection presents with symptoms of variable severity, from mild flu-like disease to severe pneumonia and cytokine storm with increased mortality. […] Immunosuppressed patients may have higher risk of adverse outcomes; hence, there is an urgent need to evaluate the immune response and clinical outcomes of SARS-CoV-2 infection in these patients. […] Here, we report a 59-year-old woman with aquaporin-4-positive (AQPR4+) neuromyelitis Optica treated with rituximab who developed mild respiratory symptoms with COVID-19, despite B cell depletion at the time of infection. | 2020-06-26 |
| 32554288 | We have defined a pathway for the access to the MS Centre with logistic, preventative and clinical recommendations, and have also included 14-day self-isolation and COVID-19 testing before some disease modifying treatments. | 2020-06-26 |
| 32554337 | Objective: The aim was to investigate the frequency and severity of STD in COVID-19 patients and to evaluate the association with demographic characteristics, hospital admission, symptoms, comorbidities, and blood biomarkers. […] STD onset time, recovery rate, time to recovery, hospital admission, pneumonia diagnosis, comorbidities, smoking and symptoms were analyzed. | 2020-06-19 |
| 32554340 | We hypothesize that a low Mg status, which is rather common, might foment the transition from mild to critical clinical manifestations of the disease. […] Epidemiological, clinical, and fundamental research is needed to clarify the potential role of Mg deficiency in COVID-19. | 2020-06-19 |
| 32554345 | Our objective was to identify, from international literature, the most common symptoms met in older adults infected with the SARS-CoV-2 virus. […] The symptoms of COVID-19 were as follows: fever, dry cough, dyspnea, asthenia, anorexia, chest tightness, diarrhea, and to a lesser extent myalgia, pharyngitis, nausea, dizziness, headache, abdominal pain and finally vomiting. | 2020-06-25 |
| 32554380 | Assessment of an eight-week web-based mindfulness and cognitive behavioural therapy (CBT) program in reducing symptoms of depression, anxiety, and stress (primary outcomes) and increasing mindfulness (secondary outcome) within a randomized controlled trial (RCT) with undergraduate students at a large Canadian university. […] With MVC intervention, there were significantly reduced depression and anxiety symptoms but no significant effect on perceived stress. | 2020-06-19 |
| 32554424 | The median time from COVID-19 symptoms to a thrombotic event was 7 days (range, 2-7 days). […] Severe and potentially fatal deep cerebral thrombosis may complicate the initial clinical presentation of COVID-19. | 2020-06-19 |
| 32554619 | Symptoms and imaging findings from IR-pneumonitis and COVID-19 pneumonia can be similar, and early COVID-19 viral testing may yield false negative results, complicating the diagnosis and management of both entities. | 2020-06-27 |
| 32554697 | While the icPEDV-infected piglets exhibited clinical disease, the icPEDV-mut4-infected piglets showed no clinical symptoms and exhibited normal intestinal pathology at day 2 post-infection. | 2020-06-19 |
| 32554730 | Clinical decision-making is largely focused on respiratory assessment and triage, and GPs feel that acute care is compromised, both by their own changed focus and by the fact that patients consult less frequently for non-covid problems. | 2020-06-24 |
| 32554734 | Gastrointestinal (GI) symptoms are seen in patients with COVID-19. […] Presenting with GI symptoms increases the risk of testing positive for SARs-CoV-2. […] Having GI symptoms has been associated with more severe disease. […] Management of GI symptoms is mainly supportive, given the lack of FDA-approved treatments for COVID-19. […] Healthcare providers should be aware of the GI manifestations of COVID-19 and perform SARS-CoV-2 testing for patients presenting with digestive changes, especially in those with respiratory symptoms. | 2020-06-19 |
| 32554771 | New-onset neurologic events as assessed by neurology consultants based on manifestations, clinical examination and investigations, in which critical events included disorders of consciousness, stroke, CNS infection, seizures and status epilepticus. | 2020-06-19 |
| 32554825 | Patients with life-threatening Covid-19-related symptoms should be urgently treated and long-term anti-tumoral treatments may be temporarily delayed. | 2020-06-19 |
| 32554832 | Objective Recently, there have been several studies on the clinical characteristics of patients with coronavirus disease 2019 (COVID-19); however, these studies have mainly been concentrated in Wuhan, China; the sample sizes of each article were different; and the reported clinical characteristics, especially blood biochemical indices, were quite different. […] These blood biochemical indicators should be considered in the clinical management of the disease. | 2020-06-19 |
| 32554907 | As various models for SARS-CoV-2 are under testing phase, biotech companies have bypassed animal studies and moved to Phase I clinical trials. | 2020-06-25 |
| 32554923 | We posit that: (a) coronaviruses activate multiple complement pathways; (b) severe COVID-19 clinical features often resemble complementopathies; (c) the combined effects of complement activation, dysregulated neutrophilia, endothelial injury, and hypercoagulability appear to be intertwined to drive the severe features of COVID-19; (d) a subset of patients with COVID-19 may have a genetic predisposition associated with complement dysregulation; and (e) these observations create a basis for clinical trials of complement inhibitors in life-threatening illness. | 2020-06-19 |
| 32554959 | Of clinical factors, only patient BMI was significantly associated with the requirement for BMV. | 2020-06-25 |
| 32554965 | Emerging data have described poor clinical outcomes from infection with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) among African American patients and those from underserved socioeconomic groups. […] We sought to describe the clinical characteristics and outcomes of acute kidney injury (AKI) in this special population. […] The onset of AKI and relation to clinical outcomes were determined. […] Those who had HA-AKI had worse clinical outcomes compared to those who with CA-AKI. | 2020-06-19 |
| 32554992 | Clinical research efforts should examine effects of strategies such as arginase inhibition alone and/or inhaled nitric oxide to ameliorate the effects of elevated NLR. | 2020-06-22 |
| 32555006 | The clinical and imaging data of 64 patients with confirmed diagnoses of COVID-19 were retrospectively selected and divided into a stable group and a progressive group according to the data obtained from the ongoing treatment process. […] We also compared the differences of signature scores in the clinical, laboratory, and CT image feature subgroups and finally analyzed the correlation between the radiomics features of the constructed signature and the other features including clinical, laboratory, and CT imaging features. | 2020-06-19 |
| 32555034 | Demographic and clinical data from delivery hospitalization records were collected, and follow-up was completed on April 20, 2020. […] During the first month of the SARS-CoV-2 outbreak in New York City and with evolving testing criteria, most women with laboratory-confirmed infection admitted for delivery did not have symptoms of COVID-19. | 2020-06-19 |
| 32555087 | Patients were monitored with clinical and radiological checkups using modified Harris Hip Score to accurately evaluate the fluctuations in the rehabilitation period. | 2020-06-22 |
| 32555133 | Successful public health interventions† to mitigate heat-related deaths include conducting outreach to vulnerable communities to increase awareness of heat-related symptoms and provide guidance for staying cool and hydrated, particularly for susceptible groups at risk such as young athletes and persons who are older or socially isolated (2). […] In light of the coronavirus disease 2019 (COVID-19) pandemic, CDC updated its guidance on the use of cooling centers to provide best practices (e.g., potential changes to staffing procedures, separate areas for persons with symptoms of COVID-19, and physical distancing) to reduce the risk for introducing and transmitting SARS COV-2, the virus that causes COVID-19, into cooling centers.§. | 2020-06-22 |
| 32555134 | This report describes demographic characteristics, underlying health conditions, symptoms, and outcomes among 1,320,488 laboratory-confirmed COVID-19 cases individually reported to CDC during January 22-May 30, 2020. | 2020-06-22 |
| 32555388 | Plasmas collected an average of 39 days after the onset of symptoms had variable half-maximal pseudovirus neutralizing titres: less than 1:50 in 33% and below 1:1,000 in 79%, while only 1% showed titres above 1:5,000. | 2020-06-19 |
| 32555424 | The clinical features and immune responses of asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been well described. […] We studied 37 asymptomatic individuals in the Wanzhou District who were diagnosed with RT-PCR-confirmed SARS-CoV-2 infections but without any relevant clinical symptoms in the preceding 14 d and during hospitalization. | 2020-06-19 |
| 32555446 | According to the information that we have collected so far, this article provides an overview of potential therapeutic drugs and compounds with much attention, including favipiravir and hydroxychloroquine, as well as traditional Chinese medicine, which have been reported with good clinical treatment effects. | 2020-06-28 |
| 32555539 | To assess the overall prevalence of clinical signs, symptoms, and radiological findings in children and/or adolescents with COVID-19. […] Data regarding clinical and radiological features were extracted from eligible studies and meta-analysis was performed using random-effects modeling. […] Subjects presented mild symptoms in 79% (95%CI 65-91%; I2 = 93.5%) of cases, whereas only 4% (95%CI 1-9%; I2 = 76.4%) were critical. […] Compared to adults, children and/or adolescents tend to have a mild COVID-19 course with a good prognosis.This study provides new and consistence information on the clinical and radiological characteristics of COVID-19 in pediatrics.This study may help to fight COVID-19 in pediatric population. | 2020-06-20 |
| 32555563 | Clinical observations showed that, in addition to the respiratory infection, a systemic inflammatory response occurs, which leads to coagulation disorders and consequent venous thromboembolism as well as other thrombotic complications. […] We here review the available literature on this issue to better understand the pathophysiological mechanisms of coagulopathy useful to draw future clinical and therapeutic conclusions. | 2020-06-19 |
| 32555564 | In the present position paper we collected current evidence from the literature to provide practical recommendations on the management of antithrombotic therapies (antiplatelet and anticoagulant) in various clinical contexts prevalent during the SARS-CoV-2 outbreak: in-home management of oral anticoagulant therapy; interactions between drugs used in the SARS-CoV-2 infection and antithrombotic agents; in-hospital management of antithrombotic therapies; diagnosis, risk stratification and treatment of in-hospital thrombotic complications. | 2020-06-19 |
| 32555565 | It seems therefore necessary that patients, especially for time-dependent diseases such as ACS, continue to refer to hospital care; that contemporary standard of care for acute cardiac disease should be guaranteed, and that intensivist cardiologists acquire specific skills for the treatment of patients with clinical conditions normally treated by other specialists. | 2020-06-19 |
| 32555674 | However, most of the clinical studies have been focused on Wuhan, and little is known about the disease outside of Wuhan in China. […] In this retrospective cohort study, we report the early clinical features of 80 patients with COVID-19 admitted to the hospital in Beijing. | 2020-06-22 |
| 32555947 | This COVID-19-specific administrative and clinical protocol can be replicated or adapted in multiple institutions and endoscopy units worldwide. | 2020-06-22 |
| 32555949 | Once patients with AI present symptoms of COVID-19, the dose of GC replacement therapy should be immediately doubled. […] In the presence of any emergency warning signs or inability to administer oral GC doses, we recommend that patients should immediately seek Emergency services to evaluate COVID-19 symptoms and receive 100 mg hydrocortisone by intravenous injection, followed by 50 mg hydrocortisone intravenously every 6 h or 200 mg/day by continuous intravenous infusion. | 2020-06-24 |
| 32555974 | The lack of vaccines and antivirals prevents clinical strategies against the disease, creating an emerging need for the development of safe and effective treatments. | 2020-06-19 |
| 32556033 | Prioritizing surgical procedures aims at facilitating patient’s access according to the clinical needs, maximizing access equity, and minimizing the damage from delayed access. […] Given the factors that contribute to the morbidity and mortality of obese and type 2 diabetes patients, surgical prioritization should be based on clinical risk stratification. […] In summary, these recommendations have been shaped after a thorough analysis of the available literature and are extremely important to mitigate the harm related to the clinical complications of obesity and its comorbidities while keeping healthcare providers’ and patients’ safety. | 2020-06-23 |
| 32556054 | Drugs already used in a clinical setting for other pathologies have been tested as a new therapeutic approach against SARS-CoV-2, setting off a frenzy over the preliminary data of different studies. […] Despite the potential effects of some antivirals and antiparasitic against COVID-19, clinical studies must confirm real effectiveness. | 2020-06-23 |
| 32556089 | The clinical course of neuroinvasion of SARS-CoV-2 is yet unclear, however an extended follow up of these patients to assess for neurological sequelae including encephalitis, cerebrovascular accidents and long-term neurodegenerative risk may be indicated. | 2020-06-19 |
| 32556147 | This clinical perspective explores the key elements of caring for individuals with DKA during the COVID-19 pandemic through two cases. | 2020-06-19 |
| 32556191 | The IDSA’s goal was to develop an evidence-based diagnostic guideline to assists clinicians, clinical laboratorians, patients and policymakers in decisions related to the optimal use of SARS-CoV-2 nucleic acid amplification tests. […] IDSA convened a multidisciplinary panel of infectious diseases clinicians, clinical microbiologists, and experts in systematic literature review to identify and prioritize clinical questions and outcomes related to the use of SARS-CoV-2 molecular diagnostics. […] Information on the clinical performance of available tests is rapidly emerging, but the quality of evidence of the current literature is considered low to very low. | 2020-06-19 |
| 32556199 | Independent predictors of left and right ventricular abnormalities were distinct, including elevated natriuretic peptides [adjusted odds ratio (OR) 2.96, 95% confidence interval (CI) 1.75-5.05) and cardiac troponin (OR 1.69, 95% CI 1.13-2.53) for the former, and severity of COVID-19 symptoms (OR 3.19, 95% CI 1.73-6.10) for the latter. | 2020-06-19 |
| 32556260 | Similar gaps were found with respect to knowledge of COVID-19 symptoms and preventive behaviors. […] In this survey study of US adults, there were gaps in reported incidence of COVID-19 and knowledge regarding its spread and symptoms and social distancing behavior. | 2020-06-24 |
| 32556323 | Hospitalized patients with COVID-19 experience a variety of symptoms, including fever, muscle pain, tiredness, cough, and difficulty breathing. […] Elderly people and those with underlying health conditions are considered to be more at risk of developing severe symptoms and have a higher risk of physical deconditioning during their hospital stay. […] A working group conducted a purposive scan of the literature and drafted initial recommendations based on the knowledge of symptoms in patients with COVID-19, and current practice for physical therapist management for patients hospitalized with lung disease and patients admitted to the intensive care unit (ICU). | 2020-06-19 |
| 32556328 | Clinical peculiarities of COVID-19 were reported in seniors. | 2020-06-19 |
| 32556400 | The aim of this series of cases is to show the aspects of ventilation/perfusion single-photon emission computed tomography combined with computed tomography (V/Q SPECT/CT) in patients hospitalized for COVID-19 pneumonia, with the worsening of respiratory symptoms raising the suspicion of a pulmonary embolism. […] Patients did not benefit from CT angiography for various reasons: a contraindication, unavailability of the CT angiography, or a low clinical probability for pulmonary embolism. | 2020-06-22 |
| 32556649 | Although several studies have reported on the clinical and epidemiological characteristics of the patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), clinical course of the most severe cases requiring treatment in ICU have been insufficiently reported. | 2020-06-22 |
| 32556746 | Technological devices such as videoconference or smartphone apps might be used for follow-up visits and support to patients and caregivers and to acquire digital markers of clinical progression. | 2020-06-22 |
| 32556781 | Most studies (95.8%) have confirmed the symptoms of anosmia in patients with SARS-CoV-2 infection. | 2020-06-22 |
| 32556793 | The clinical care of patients with pituitary disorders typically involves a multidisciplinary team, working in concert to deliver timely, often complex, disease investigation and management, including pituitary surgery. […] In the absence of clinical trials to guide management of patients with pituitary disease during the COVID-19 pandemic, herein the Professional Education Committee of the Pituitary Society proposes guidance for continued safe management and care of this population. | 2020-06-26 |
| 32556796 | Surgeons should incorporate collection of social determinants of health into their clinical practice to better understand the impact of COVID-19 on racial and ethnic disparities in surgical management. | 2020-06-28 |
| 32556815 | Closed-ended, multiple choice questions were focused on the experience of neurosurgical residents in the last 2 months (from March to May 2020) concerning both clinical and educational aspects. […] According to the participants’ responses, in the whole country, only 29.7% of residents were directly involved in the clinical management of COVID-19 patients. | 2020-06-22 |
| 32556942 | The innate immune system is therefore a potentially important target for therapeutic treatment of COVID-19, but experimental studies are needed, and SARS-CoV-2 presents unique challenges for pre-clinical and mechanistic studies in vivo. | 2020-06-22 |
| 32557183 | The second aim is to suggest minimally invasive treatment alternatives for caries management, minimising the risk of viral cross-infection and offering a safer clinical environment. | 2020-06-22 |
| 32557207 | The survey was composed of different sections concerning demographic characteristics and impacts of COVID-19 on the concrete participation in clinical, surgical and research activities. […] Almost 35 and 27% of respondents experienced, respectively, complete interruption of surgical and clinical activities. […] A subgroup analysis, comparing the COVID-19 impact on clinical activities with demographics data, showed a statistically significant difference related to specialties (p = 0.0062) and Italian regions (p < 0.0001). | 2020-06-22 |
| 32557250 | The standards consisted of seven core principles of medical care for physicians working in nursing homes as a first step in developing a programme of clinical, academic and policy engagement in improving medical care for older people who are living and frequently also dying as residents in nursing homes. | 2020-06-22 |
| 32557332 | The elderly may represent a specific cluster of high-risk patients for developing COVID-19 with rapidly progressive clinical deterioration. […] Our review examines the pathogenesis and clinical implications of ageing in COVID-19 patients; finally, we discuss the evidence and controversies in the management in the long-stay residential care homes and aspects of end-of-life care for elderly patients with COVID-19. | 2020-06-22 |
| 32557489 | 12.8% (89/694) of the gastroenterologists reported symptoms compatible with COVID-19 infection, and a positive PCR was recorded in 12/197 (6.1%) vs. | 2020-06-19 |
| 32557533 | During the COVID-19 pandemic, principles from both clinical and public health ethics cue clinicians and health care administrators to plan alternatives for frail older adults who prefer to avoid critical care, and for when critical care is not available due to crisis triaging. | 2020-06-19 |
| 32557535 | However, other clinical, biological and radiological factors strongly impact COVID-19 outcome. | 2020-06-19 |
| 32557541 | Given these points, we reviewed the current evidence regarding the potential therapeutic role of tocilizumab and its important clinical issues in the treatment of ARDS related to COVID-19. | 2020-06-19 |
| 32557593 | For intensivists and anaesthetists the clinical workload has been incomparable, with multiple challenges for those providing frontline care. | 2020-06-19 |
| 32557596 | Currently, the complexity of clinical trial development in oncology is being further complicated by the coronavirus disease 2019 (COVID-19) pandemic, which is reducing the resources needed to comply with protocol-specific procedures while putting patients in units, who are already vulnerable, at increased general risk not only for COVID-19 infection but also with respect to their baseline disease. […] Individualizing the management of patients while ensuring their safety and adherence to the study protocol, establishing specific staff contingency plans, and maintaining sponsor and contract research organization (CRO) alignment are some of the key issues for maintaining the continuity of cancer patients’ investigational treatment and minimizing their infection risk as well as the risk to staff members of the unit, sponsors, and CROs while maintaining the integrity of data quality and compliance with good clinical practice. | 2020-06-22 |
| 32557789 | This aim of this systematic review and meta-analysis was to evaluate the clinical characteristics of COVID-19 in neonates and children under one year of age. […] We included all papers that addressed clinical manifestations, laboratory results, imaging findings and outcomes in infants and neonates. […] The most common clinical symptoms were fever (54%) and cough (33%). | 2020-06-19 |
| 32557847 | When hospitalized, she showed fever, nasal congestion and pneumonia symptoms. | 2020-06-19 |
| 32557907 | Quality clinical research remains a high priority during the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) coronavirus disease (COVID-19) pandemic response, however, the logistical barriers of conducting research across institutions with differing departmental policy responses and varying resources is a documented problem. | 2020-06-19 |
| 32557965 | The most common signs and symptoms are fever, dry cough and shortness of breath which can progress to severe viral pneumonia and multi-organ failure in susceptive patients (Chen et al. | 2020-06-19 |
| 32558002 | Although the main clinical features of COVID-19 infection are pulmonary, several associated neurological signs, symptoms and diseases are emerging. […] For this reason, the European Academy of Neurology (EAN) core COVID-19 Task Force initiated a survey on neurological symptoms observed in patients with COVID-19 infection. […] Neurological manifestations were generally interpreted as being possibly related to COVID-19, they were most commonly recognized in patients with multiple general symptoms, and occurred at any time during infection. | 2020-06-19 |
| 32558075 | The clinical presentation of COVID-19-associated coagulopathy is organ dysfunction primarily, while hemorrhagic events are less frequent. | 2020-06-19 |
| 32558175 | We calculated the incubation period of the cases as the interval between infection and development of symptoms. | 2020-06-19 |
| 32558193 | Databases of PubMed, Scopus, Google Scholar, Medscape and CEBD coronavirus dermatology resource of Nottingham University searched completely and initial 237 articles selected to further review and finally nine articles (including 12 patients) entered to this study. from 12 patients with chronic underlying dermatologic disease treated with systemic therapies, only one patient required ICU admission, the others have been treated for mild- moderate symptoms with conventional therapies. […] Their treatment has been continued as before, after the symptoms improved. | 2020-06-19 |
| 32558198 | Study analyzed clinical and biological profiles of patients with suspected COVID-19 infection at admission, including hemostasis tests and quantification of circulating endothelial cells (CECs). | 2020-06-19 |
| 32558211 | We also review pertinent clinical considerations in the management of diabetic ketoacidosis in the COVID-19 patient. | 2020-06-19 |
| 32558285 | The spectrum of clinical manifestations of coronavirus disease 2019 in children is yet to be fully elucidated. | 2020-06-19 |
| 32558514 | It presents as a febrile condition with respiratory symptoms and high transmissibility rate. […] There is no vaccine, so the clinical suspicion and immediate isolation of the patient are essential The purpose of this work is to report the first confirmed case of COVID-19 disease in Córdoba (Argentina), highlighting telemedicine as a novel form of outpatient management. […] We describe the first confirmed case of COVID-19 disease in Córdoba (Argentina), which presented in a patient without comorbidities in good clinical condition, and therefore ambulatory management using telemedicine was decided, which was satisfactory. | 2020-06-24 |
| 32558518 | Dear Director: Reading your article “The pandemic due to the new covid-19 coronavirus”, I would like to deepen the contributions of the symptoms of this disease. | 2020-06-24 |
| 32558620 | We review the laboratory and clinical findings of patients with COVID-19-associated coagulopathy, and prior studies of hemostasis in other viral infections and acute respiratory distress syndrome. […] The role various components including neutrophils, neutrophil extracellular traps, activated platelets, microparticles, clotting factors, inflammatory cytokines, and complement play in this process remains an area of active investigation and ongoing clinical trials target these different pathways in COVID-19. | 2020-06-26 |
| 32558644 | 26/169 (15%) HCWs with symptoms of coronavirus disease 2019 (COVID-19) also tested positive (Rivett et al., 2020). | 2020-06-19 |
| 32558646 | Final clinical diagnosis was COVID-19 in 98 patients (12%). | 2020-06-19 |
| 32558697 | So the aim of this review was to illustrate the clinical implications of COVID-19 on the liver in healthy and diseased states as well as the implications of common liver disorders on the outcome of COVID-19. | 2020-06-19 |
| 32558722 | It led us to improve patient flow and to undertake broader measures to avoid patient clinical issues and potential disease spreading. | 2020-06-19 |
| 32558725 | Demographics and clinical data were extracted from the electronic medical record system. […] Common symptoms at presentation were fever (73%), cough (77%), and gastrointestinal symptoms (59%). | 2020-06-19 |
| 32558815 | Laboratory confirmation of COVID-19 cases allows the appropriate clinical management and public health interventions. | 2020-06-22 |
| 32558821 | The most common symptoms reported were cough (55%), fever (37%) and sore throat (35%). | 2020-06-22 |
| 32558945 | Demographic information, epidemiologic data, clinical features and treatment data were extracted from medical records. | 2020-06-19 |
| 32558946 | COVID-19, caused by SARS-CoV-2, leads to a series of clinical symptoms of respiratory and pulmonary inflammatory reactions via unknown pathologic mechanisms related to the viral infection process in tracheal or bronchial epithelial cells. | 2020-06-19 |
| 32558947 | We reviewed the clinical and epidemiological records of all discharged patients and apply log-binomial models to obtain risk ratios for re-positive status. | 2020-06-19 |
| 32558955 | Data on clinical symptoms of pediatric inpatients with COVID-19 infection were unclear. […] The aim of study was to investigate the clinical features of pediatric inpatients with SARS-CoV-2 infection. […] As the results shown, fever (46%) and cough (42%) were the main clinical characters of pediatric inpatients with SARS-CoV-2 infection and the other clinical characters such as Diarrhea, Vomiting, Nasal congestion, and Fatigue account for 10% in pediatric inpatients. […] In conclusion, compared with adult inpatients with SARS-CoV-2 infection, the pediatric inpatients had mild clinical characters, lab test indicators, and chest imaging features. […] More clinical studies focus on the pediatric patients with SARS-CoV-2 infection in other countries should be conducted. | 2020-06-19 |
| 32558956 | Altered consciousness, ranging from mild confusion, delirium, to deep coma, is hallmark clinical features. […] Encephalopathy is always preceded by commoner clinical features, like, fever, cough, dyspnoea, and headache. | 2020-06-19 |
| 32558961 | The few data published on COVID-19 in the blood-oncology field report a serious clinical presentation, a serious course of the disease and a high mortality rate, as has also been reported for other cancer contexts. | 2020-06-19 |
| 32558963 | The Centers for Disease Control and Prevention (CDC) suggest several possible symptoms associated with coronavirus disease 2019 (COVID-19), including cough, shortness of breath or difficulty breathing, fever, chills, muscle pain, sore throat, new loss of taste or smell, and less commonly nausea/vomiting/diarrhea.1 This article is protected by copyright. | 2020-06-19 |
| 32558969 | The DOH and DCPEM, in close collaboration with the Department of Clinical Microbiology and Internal Medicine Services at Landspitali-The National University Hospital (LUH) and deCODE genetics, initiated a nationwide surveillance program for COVID-19, including diagnostic testing which began on 31 January. | 2020-06-19 |
| 32558983 | The literature has outlined several signs and symptoms of COVID-19 (Lake, 2020), but there are some manifestations not yet confirmed or not entirely described. | 2020-06-19 |
| 32559026 | There are a variety of ventilator options available to the emergency clinician, and decisions on choosing optimal settings will depend on the clinical circumstances. | 2020-06-22 |
| 32559180 | Interestingly, metabolite levels in these pathways correlated with clinical laboratory markers of inflammation (i.e., IL-6 and C-reactive protein) and renal function (i.e., blood urea nitrogen). […] In conclusion, this initial observational study identified amino acid and fatty acid metabolism as correlates of COVID-19, providing mechanistic insights, potential markers of clinical severity, and potential therapeutic targets. | 2020-06-19 |
| 32559282 | Understanding the prevalence and clinical presentation of COVID-19 in pediatric patients can help healthcare providers and systems prepare and respond to this emerging pandemic. […] Retrospective case series of patients tested for SARS-CoV-2 across a pediatric healthcare network, including the clinical features and outcomes of those with positive test results. […] Of those with an indication for testing, 21.1% (371/1756) of patients with reported exposures or clinical symptoms tested positive vs. | 2020-06-19 |
| 32559285 | The ongoing COVID-19 pandemic has forced the clinical and scientific community to try drug repurposing of existing antiviral agents as a quick option against SARS-CoV-2. […] Under this scenario, the interferon-β 1a (IFN-β 1a) whose antiviral potential is already known, and is a drug currently used in the clinical management of multiple sclerosis, may represent as a potential candidate. | 2020-06-19 |
| 32559324 | Besides pneumonia and acute respiratory distress syndrome, the disease leads to multisystem involvement in the form of myocarditis, arrhythmias, cardiac arrest, gastrointestinal symptoms, hypoxemic brain injury, acute liver and renal function impairment. | 2020-06-19 |
| 32559354 | Her hepatitis and respiratory symptoms improved coincident with completing treatment with hydroxychloroquine, reduced immunosuppression, and intravenous gamma globulin (IVIG). | 2020-06-25 |
| 32559419 | Since GM-CSF also has a key role in homoeostasis and host defence, we discuss potential risks associated with inhibition of GM-CSF in the context of viral infection and the challenges of doing clinical trials in this setting, highlighting in particular the need for a patient risk-stratification algorithm. | 2020-06-19 |
| 32559589 | The clinical trials failed to find any significant relation between seizures and chloroquine or hydroxychloroquine. | 2020-06-23 |
| 32559771 | Only one clinical study evaluated the drug in dengue virus infection without any clinical efficacy. […] However, the proposed mechanism of drug action, by inhibiting the importin family of nucleus-cytoplasmic transporters along with favourable pharmacokinetics, warrants exploration of its role in COVID 19 through safely conducted clinical trials. […] Being an available and affordable drug, enlisted in WHO List of Essential Medicine, and a long track record of clinical safety, the drug is already in clinical trials the world over. | 2020-06-19 |
| 32559820 | In the absence of a commonly agreed dosing protocol based on pharmacokinetic considerations, the dose and treatment duration for hydroxychloroquine (HCQ) COVID-19 disease currently vary across national guidelines and clinical study protocols. […] Clinical efficacy and safety information from COVID-19 patients treated with HCQ were used to contextualize and assess the actual clinical value of the model predictions. […] Literature and observed clinical data confirm the variability in clinical responses in COVID-19 when treated with the same fixed doses. | 2020-06-19 |
| 32560044 | We aimed to compare the sensitivity and specificity of these different RT-PCR assays using SARS-CoV-2 cell culture supernatants and clinical respiratory samples. | 2020-06-22 |
| 32560180 | The aims of this study were to determine the prevalence of symptoms, main concerns as patients, preventive behaviours of healthcare professionals, and the different temporal outcomes associated with the negativization of PCR results. […] A total of 238 professionals were analysed and follow-up was conducted from 11 March to 21 April 2020 through clinical records, in-depth surveys, and telephone interviews. […] Symptoms, concerns, and preventive measures were documented, and temporal outcomes (start and end of symptoms, first positive PCR, and negativization of PCR) were analysed through survival analyses. […] A high prevalence of gastrointestinal symptoms (especially in women and older professionals), fever, cough, and fatigue were reported. […] Our analysis indicates that the median times for the negativization of PCR testing to confirm the resolution of infection is 15 days after the end of symptoms, or 25 days after the first positive PCR test. | 2020-06-25 |
| 32560227 | The virus causes severe respiratory symptoms which manifest disproportionately in the elderly. | 2020-06-22 |
| 32560322 | Randomized clinical trials, cross sectional, observational, and case-control studies were evaluated with the Mixed Methods Appraisal Tool for quality assessment and study limitations. | 2020-06-22 |
| 32560658 | In all these situations, therapeutic doses of LMWH, or UFH in case of renal insufficiency with monitoring of anti-Xa activity, are proposed.In conclusion, intensification of heparin treatment should be considered in the context of COVID-19 on the basis of clinical and biological criteria of severity, especially in severely ill ventilated patients, for whom the diagnosis of pulmonary embolism cannot be easily confirmed. | 2020-06-23 |
| 32560667 | Viewing COVID-19 with a Critical Medical Ecological lens suggests three important interpretations: 1) COVID-19 is equally - if not more - a socially-driven disease as much as a biomedical disease, 2) the present interventions available for primary prevention of transmission are social and behavioral interventions, and 3) wide variation in COVID-19 hospitalization/death rates is not expected to significantly be attributable to a more virulent and rapidly-evolving virus, but rather to differences in social and behavioral factors - and power dynamics - rather than (solely) biological and clinical factors. | 2020-06-23 |
| 32560671 | Most of the patients had a history of visiting Hubei Province or contacting with people who had ever stayed in or passed by Hubei Province or were exposed to symptoms. […] Fever symptoms appeared on 28 January, with a maximum temperature of 38.8 °C, accompanied by cough, sore throat, headache, fatigue, muscle ache, joint ache, and other symptoms. […] The symptoms continued until he was hospitalized on 30 January. | 2020-06-23 |
| 32560694 | We aimed to analyze the demographics, clinical characteristics and treatment of 61 patients. […] Our findings provide the important information and clinical evidence for the improved management of patients recovered from COVID-19. | 2020-06-23 |
| 32560744 | We will include both severe and mild-moderate patients defined as follows: Group A (severe disease) - patients with WHO Working Group on the Clinical Characteristics of COVID-19 infection 9-point ordinal scale of Grades 4 (hospitalised, oxygen by mask or nasal prongs), 5 (hospitalised, non-invasive ventilation or high flow oxygen), 6 (hospitalised, intubation and mechanical ventilation) or 7 (hospitalised, ventilation and additional organ support); Group B (mild-moderate disease) - ambulant or hospitalised patients with peripheral capillary oxygen saturation (SpO2) >94% RA. […] But may include; time to clinical improvement of at least 2 points on the WHO 9-point category ordinal scale [measured up to 29 days from randomisation], progression of disease (oxygen saturation (SaO2) <92%) or hospitalization or death, or change in time-weighted viral load [measured up to 29 days from randomisation]. | 2020-06-22 |
| 32560745 | The full protocol has been reported in accordance with the Standard Protocol Items: Recommendations for Clinical Interventional Trials (SPIRIT) guidelines. | 2020-06-22 |
| 32560746 | COVIDornase is a prospective, randomized, controlled, 2-arm (1:1 ratio), multicentric, open-label clinical trial. […] The remainder of the management will be performed in accordance with good clinical practice, including mechanical ventilation (protective ventilation, PEEP > 5 cmH2O, tracheal balloon pressure check every 4 hours or automatic device, 30° head of the bed elevation, tidal volume 6-8mL/kg, plateau pressure < 30 cmH2O), neuromuscular blockers if necessary, prone position if PaO2/FiO2 < 150, early enteral nutrition, glycemic control and a sedation protocol based on the RASS score. | 2020-06-22 |
| 32560875 | Safety netting is a recognised General Practitioner (GP) diagnostic strategy often used in the face of uncertainty to help ensure that a patient with unresolved or worsening symptoms knows when and how to access further advice. […] It is an important way of reducing clinical risk. […] Screening for Red Flags and any indication of a serious cause of symptoms is always first line in any consultation, however, clinical presentations are not always black and white with patients falling into a clear diagnostic category. […] With patients minds more focussed on COVID-19 symptoms this can be problematic. […] In situations of uncertain clinical presentations, to avoid unnecessary social contact, safety netting can help to monitor symptoms over time until the clinical context becomes more certain. | 2020-06-23 |
| 32560915 | The cases were confirmed using real-time reverse transcription-polymerase chain reaction, and we analysed epidemiological, demographic and clinical data. | 2020-06-23 |
| 32561113 | Numerous potential therapies, including supportive intervention, immunomodulatory agents, antiviral therapy, and convalescent plasma transfusion, have been used in clinical practice. […] Herein, we summarize the current potential therapeutic approaches for diseases related to COVID-19 infection and discusses the clinical value of blood transfusion-related technologies used in COVID-19 treatment. | 2020-06-20 |
| 32561148 | The authors, therefore, encourage the enrollment of eligible patients to multiple ongoing clinical trials that assess the efficacy and safety of these candidate therapies. | 2020-06-23 |
| 32561172 | Policy changes relating to three domains of program structure and care processes were identified: internal structure, clinical workflow, and COVID-19 safety/prevention. […] Interhospital consensus was high for reducing in-hospital staffing, limiting clinical fellow exposure, implementing telehealth for conducting outpatient clinical visits, and using universal precautions for trauma. | 2020-06-23 |
| 32561216 | A series of questions considered to be of clinical and logistical relevance were formulated. | 2020-06-23 |
| 32561220 | There were no differences between groups tested positive and negative in regard to demographic and clinical characteristics such as presence of allergy, rhinitis, neither to olfactory recovery time. | 2020-06-23 |
| 32561222 | It typically presents with mild upper respiratory tract infection symptoms and may have life threatening complications, including acute respiratory distress syndrome, acute stroke, myocardial infarction, kidney failure, shock, and even death. […] We analyzed COVID-19 adult patients in the TriNetX database, which is a global health collaborative clinical research platform collecting real-time electronic medical records data from a network of health care organizations (HCOs) from January 20, 2020 to June 10th, 2020. 40,469 patients were diagnosed with COVID-19 among whom 9086 (22.5%) patients had neuropsychiatric manifestations. | 2020-06-23 |
| 32561227 | These departments will need to adapt their operations to accomodate COVID-19 and to continue to meet their tripartite mission of clinical excellence, medical education, and women’s health research. | 2020-06-22 |
| 32561253 | Perioperative and perianesthesia nurses are vital to the overall nursing viability of the health care system, as they possess the requisite knowledge and skills to provide expert clinical care in many hospital settings and meet the demands of a global pandemic. | 2020-06-23 |
| 32561268 | None imposed age restrictions regarding older VSs continuing clinical hospital work. […] The majority of VSs in the Philadelphia area have dramatically adjusted their clinical practices before the COVID-19 crisis reached peak levels experienced in other metropolitan areas. | 2020-06-22 |
| 32561270 | We isolated B cells specific for the SARS-CoV-2 envelope glycoprotein spike (S) from a COVID-19-infected subject 21 days after the onset of clinical disease. | 2020-06-23 |
| 32561276 | The study examined whether subjective age moderated the relationship between loneliness due to the COVID-19 pandemic and psychiatric symptoms. […] A convenience sample of older adult Israelis (N = 277, mean age = 69.58 ± 6.72) completed web-based questionnaires comprising loneliness, anxiety, depressive, and peritraumatic distress symptoms. […] The positive relationship between loneliness due to the COVID-19 pandemic and psychiatric symptoms was weak among those who felt younger than their age while this very same relationship was robust among those feeling older. | 2020-06-23 |
| 32561291 | In December 2019, many pneumonia cases with unidentified sources appeared in Wuhan, Hubei, China, with clinical symptoms like viral pneumonia. | 2020-06-28 |
| 32561333 | The majority foresaw an increase in waiting lists (93.8% for initial consultations, 89.6% for follow-up, and 89.4% for procedures) and a worse clinical situation for patients, but only 15% believed that their healthcare structures would be negatively affected in the future. | 2020-06-23 |
| 32561366 | Clinical symptoms in classically affected males include acroparesthesia, anhydrosis and angiokeratoma, which may present during childhood followed by cardiac, cerebral and renal complications. […] Effects of temporary treatment interruption was described in more detail in other lysosomal storage diseases, but the recommencement of therapy does not fully reverse clinical decline due to the temporary discontinuation. | 2020-06-23 |
| 32561409 | Clinical descriptions about influenza-like illnesses (ILI) in COVID-19 seem non-specific. […] We aimed to compare the clinical features of COVID-19 and influenza. […] We retrospectively investigated the clinical features and outcomes of confirmed cases of COVID-19 and influenza in Nord Franche-Comté Hospital between February 26th and March 14th 2020. […] We described several clinical differences which can help the clinicians during the co-circulation of influenza and SARS-CoV-2. | 2020-06-23 |
| 32561497 | It included questions on service provision, disease burden and on the clinical course of confirmed cases of COVID-19 infection among children with asthma. […] Clinical services have rapidly responded to the pandemic by limiting and replacing physical appointments with virtual encounters. | 2020-06-28 |
| 32561524 | Our simple audit model is widely applicable to avoid pandemic-related delay in clinical diagnosis of cancer. | 2020-06-20 |
| 32561657 | Following the lead of other countries conducting clinical trials with the live attenuated Mycobacterium bovis BCG (BCG) vaccine under a similar concept, a clinical trial with MMR in high-risk populations may provide a “low-risk-high-reward” preventive measure in saving lives during this unprecedented COVID-19 pandemic. | 2020-06-27 |
| 32561660 | This paper argues that while a landmark document, the WHO guide took a narrowly clinical bioethics perspective and missed crucial moral dilemmas. | 2020-06-20 |
| 32561692 | The influence of the baseline characteristics, clinical symptoms, laboratory parameters and the types of mental disorders on prognosis were analyzed. | 2020-06-20 |
| 32561849 | Seven autopsy cases (male, N = 5; female, N = 2) with reverse transcriptase-polymerase chain reaction (RT-PCR)-confirmed SARS-CoV-2 infection and a median age of 66 years (range, 50-77 years) were evaluated using a rabbit polyclonal antibody against SARS Nucleocapsid protein in correlation with clinical parameters. | 2020-06-23 |
| 32561873 | Several clinical studies are underway that test the effects of inhibiting IL-6, IL-1β or TNF or targeting cytokine signalling via Janus kinase inhibition in the treatment of COVID-19. […] Despite these similarities, COVID-19 and other zoonotic coronavirus-mediated diseases do not induce clinical arthritis, suggesting that a local inflammatory niche develops in alveolar structures and drives the disease process. | 2020-06-23 |
| 32562033 | This paper represents the authors’ collaborative attempt to both reflect the changes to clinical practice we have observed in CMHCs across the US during this pandemic and to suggest how these changes can align with best practices identified in the empirical literature. | 2020-06-23 |
| 32562137 | Normal breathing and speaking are capable of producing aerosols so mask ventilation, suction of airway tract and bucking during tracheal intubation and extubation are clinical procedures capable of significant aerosol production. | 2020-06-23 |
| 32562159 | Patient’s data including clinical and laboratory parameters were recorded. | 2020-06-23 |
| 32562351 | Understanding the risk, recommendations for clinical practice are provided. | 2020-06-20 |
| 32562427 | COVID-19 infection may result in cardiovascular manifestations leading to worse clinical outcome. | 2020-06-20 |
| 32562480 | Importantly, the final analysis of these trials should be done through an extensive reading of the results in regard to the clinical design, it will be crucial to carefully read and evaluate the results of each study in regards to the clinical design rather than quickly glancing a 140 characters-based social media message announcing the failure or success of a drug against a disease. | 2020-06-22 |
| 32562550 | Coronavirus disease 2019 (COVID-19) is a multiorgan disease with multiple faces and clinical features. […] Most patients present with none or only mild symptoms, but severe presentations with need for mechanical ventilation and high case fatality may be observed. | 2020-06-20 |
| 32562554 | We aimed to investigate the role of peripheral blood eosinophil (EOS) as a marker in the course of the virus infection to improve the efficiency of diagnosis and evaluation of COVID-19 patients. 227 pneumonia patients who visited the fever clinics in Shanghai General Hospital and 97 hospitalized COVID-19 patients admitted to Shanghai Public Health Clinical Center were involved in a retrospective research study. […] Clinical, laboratory, and radiologic data were collected. | 2020-06-20 |
| 32562561 | Cough (84.2%), fever (57.9%) and dyspnea (47.4%) were the most common symptoms. […] Two patients (10.5%) died, 10 (52.6%) were discharged home, and 2 (10.5%) were still hospitalized after a median follow-up of 41 days from the onset of symptoms. | 2020-06-20 |
| 32562567 | Although the clinical and histopathological features were similar to other forms of chilblains, the presence of viral particles in the endothelium and the histological evidence of vascular damage, support a causal relation of the lesions with SARS-CoV-2. | 2020-06-20 |
| 32562594 | While the trade-off between societal and individual interests that occurs at the intersection of public health ethics and clinical ethics affects all populations, this calculus has particular relevance for pregnant women and the question of when they will have access to new Covid-19 therapies and vaccines. […] Pregnant women are a “scientifically complex” population whose inclusion in clinical research must be done with consideration of the unique state of pregnancy. […] In a rush to prevent and treat SARS-CoV-2 infection, it is crucial that the interests of pregnant women be prioritized to enable them to make autonomous, informed decisions about participating in clinical trials. | 2020-06-20 |
| 32562665 | To explore ABO blood group distribution and clinical characteristics in patients with COVID-19. […] The clinical data of 187 patients with COVID-19 seen between January 20, 2020 and March 5, 2020 at the First Hospital of Changsha were retrospectively analyzed. […] The relationship between blood type and clinical characteristics was analyzed. […] Blood type was related to some clinical characteristics of patients with COVID-19. | 2020-06-27 |
| 32562704 | Online search data was used to explore a connection between COVID-19 and ocular symptoms. | 2020-06-20 |
| 32562746 | However, COVID-19 does share many similar symptoms with SARS and influenza. […] Previous scientific discoveries learned from lab animal models and clinical practices shed light on possible pathogenic mechanisms in COVID-19. | 2020-06-27 |
| 32562764 | In this review evolving research and clinical data on gastrointestinal SARS-CoV-2 infection are discussed in the context of viral fusion and entry mechanisms, focusing on the different triggers used by coronaviruses. | 2020-06-26 |
| 32562846 | Pooled incidence rates of clinical characteristics were analysed using random effects models. […] More than half of patients without any symptoms present with CT abnormalities. | 2020-06-20 |
| 32562912 | Most pediatric patients with COVID-19 are asymptomatic or show only mild symptoms. | 2020-06-26 |
| 32562931 | Data collected on predictors included sex, age, marital status, employment, annual income, region, current smoking, current alcohol consumption, physical multimorbidity, any physical symptoms experienced during self-isolation/social distancing, and the number of days of self-isolation/social distancing. | 2020-06-26 |
| 32562988 | COVID-19 seems as global emergency, by infectious virus, caused respiratory illness like having symptoms of flue, sickness, headache, and difficulty in breathing. | 2020-06-23 |
| 32563013 | Subclinical COVID-19 subjects pose a significant challenge. […] We present a very close clinical interaction with a subclinical COVID-19 subject that met the “standard screening criteria” and is unique in several ways. […] Learning from our experience, we suggest close attention should be paid to any unexpected findings such as groundglass opacity on CT as it could help early identification of subclinical COVID-19 infection. | 2020-06-26 |
| 32563019 | Anosmia can occur alone or can be accompanied by other symptoms of COVID-19, such as a dry cough. […] However, the pathogenic mechanism of olfactory dysfunction and its clinical characteristics in patients with COVID-19 remains unclear. | 2020-06-25 |
| 32563180 | Preferably, the performance of serological tests for a novel virus should be determined with clinical specimens against a gold standard, i.e. virus neutralisation. | 2020-06-26 |
| 32563187 | Clinical manifestations of COVID-19 vary from asymptomatic virus shedding, non-specific pharyngitis, to pneumonia with silent hypoxia and respiratory failure. | 2020-06-20 |
| 32563190 | FIB-4, clinical and biochemical variables were collected at baseline. | 2020-06-20 |
| 32563194 | We suggest that combinatorial analysis of serum cytokines and chemokines with clinical classification may contribute to evaluate the severity of COVID-19 and optimize the therapeutic strategies. | 2020-06-20 |
| 32563232 | Olfactory and gustatory dysfunctions (OGD) are pathognomonic symptoms in patients with Coronavirus Disease 2019 (COVID-19). | 2020-06-21 |
| 32563234 | During the initial pandemic wave of COVID-19, apart from common presenting symptoms (cough, fever, and fatigue), many countries have reported a sudden increase in the number of smell and taste dysfunction patients. […] However, loss of smell could be presented in COVID-19 patients without other rhinologic symptoms or significant nasal inflammation. | 2020-06-21 |
| 32563271 | Depending on the different involvement of the disease, the most common symptoms are fever, cough, and dyspnea. […] However, some indeterminate symptoms that make diagnosis difficult, such as myalgia and fatigue, can also be seen alone, without the typical clinical picture. […] Apart from the typical symptoms leading to the typical diagnosis of COVID-19 at the first admission, SARS-CoV-2 related with rhabdomyolysis should also be kept in mind. | 2020-06-21 |
| 32563283 | We summarise key changes related to service allocation, clinical and supportive care, clinical trial participation, and ethical considerations regarding the use of lifesaving measures for these patients. | 2020-06-24 |
| 32563566 | We conducted a survey with sections addressing hospital characteristics, changes in infrastructure and resources, code stroke clinical pathways, diagnostic testing, rehabilitation, and outpatient care. | 2020-06-24 |
| 32563584 | Within 24 hours, he showed significant improvement in symptoms, oxygen requirements, radiological findings, and inflammatory markers. […] He was discharged home on day 11, with negative nasopharyngeal SARS-CoV-2 PCR as an outpatient on day 35, development of positive serum COVID-19 IgG antibody, and he continued to do well on day 60, with no heart-related symptoms. […] Clinical trials of clazakizumab for treatment of COVID-19 are underway worldwide. | 2020-06-24 |
| 32563593 | A review of the relevant literature was performed and different clinical scenarios were categorized into three priority groups. […] For each stage and clinical scenario in cervical, endometrial, vulvar, vaginal and ovarian cancer, specific recommendations regarding dose, technique, and timing were provided by the panel. […] Specific recommendations have been provided for common clinical scenarios encountered in gynecologic radiation oncology with a focus on strategies to reduce patient and staff exposure to COVID-19. | 2020-06-24 |
| 32563600 | We seek to describe the medical history and clinical findings of patients attending the emergency department (ED) with suspected coronavirus disease 2019 (COVID-19) and estimate the diagnostic accuracy of patients’ characteristics for predicting COVID-19. […] We abstracted medical history, physical examination findings, and the clinical probability of COVID-19 (low, moderate, and high) rated by emergency physicians, depending on their clinical judgment. […] Reverse-transcriptase polymerase chain reaction result was more likely to be negative when the emergency physician thought that clinical probability was low, and more likely to be positive when he or she thought that it was high. […] The absence of a high clinical probability determined by the emergency physician and the absence of bilateral B lines on lung ultrasonography had the lowest negative likelihood ratio for the diagnosis of COVID-19 (0.33, 95% CI 0.25 to 0.43; and 0.26, 95% CI 0.15 to 0.45, respectively). […] Anosmia, emergency physician estimate of high clinical probability, and bilateral B lines on lung ultrasonography increased the likelihood of identifying COVID-19 in patients presenting to the ED. | 2020-06-24 |
| 32563601 | We conducted a retrospective cohort study of all persons under investigation and presenting to a large academic medical center emergency department (ED) in New York State with symptoms suggestive of COVID-19. | 2020-06-24 |
| 32563685 | The disparities in outcomes, which are largely attributable to a greater prevalence of comorbidities such as hypertension and obesity, in addition to adverse environmental and socioeconomic factors, highlight the necessity of specialized clinical approaches and programs for African Americans to address longstanding barriers to equitable care. | 2020-06-24 |
| 32563697 | This biobank can provide applicants with biosamples, such as serum, DNA and RNA, and also the clinical and genomic data, so as to accelerate the COVID-19 treatment and prevention research in Taiwan. | 2020-06-24 |
| 32563698 | All of the old drugs identified as having activity against FIPV and HCoV-OC43 have seen clinical use in their respective indications and are associated with known dosing schedules and adverse effect or toxicity profiles in humans. | 2020-06-24 |
| 32563739 | Of the contacts, 186 (6.2%) developed symptoms, and 71 (2.4%) had confirmed SARS-CoV-2 infection. […] The main symptoms were cough and fever. | 2020-06-24 |
| 32563812 | In light of the COVID-19 pandemic, this review presents comprehensive information on remdesivir, including information regarding the milestones, intellectual properties, anti-coronavirus mechanisms, preclinical research and clinical trials, and in particular, the chemical synthesis, pharmacology, toxicology, pharmacodynamics and pharmacokinetics of remdesivir. | 2020-06-23 |
| 32563951 | In response to Voitsidis et al. (2020) published in Psychiatry Research addressing the paucity of research on insomnia during a pandemic, we obtained data from an online cross-sectional survey by documenting the prevalence of clinical insomnia and its contributing factors in a French general public sample. […] In our sample, 19.1% met the diagnostic criteria of clinical insomnia, which was twice lower than that reported in the study by Voitsidis et al., but close to those found among Chinese and Italian populations. […] We confirmed COVID-19-related worries and loneliness to be the major contributing factors to clinical insomnia, in addition to education status, being infected by the virus and pre-existing mental health illness. | 2020-06-24 |
| 32563968 | Patients with symptoms and/or COVID-19+ are not discussed in this document and are managed within the framework of specific channels. | 2020-06-24 |
| 32563969 | Information on treatment of COVID-19 infection in renal transplant recipients is scarce, especially in symptomatic patients and patients with recent major clinical events. | 2020-06-26 |
| 32564002 | Our experience indicates that convalescent plasma therapy is well tolerated and could potentially improve clinical outcomes. […] Optimal dose and timing as well as precise assessment of clinical benefit of convalescent plasma therapy will need further investigation in larger, well-controlled trials. | 2020-06-23 |
| 32564047 | The effectiveness of the drug in the first stage of infection by SARS-CoV-2 was confirmed in clinical observations and the drug was included in the developed therapeutic recommendations. | 2020-06-25 |
| 32564071 | In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, 8 other, ages 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. […] Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. | 2020-06-21 |
| 32564153 | Here, we report a case of a patient with mild respiratory symptoms and neurological manifestations compatible with clinically isolated syndrome. […] This report suggests a possible association of SARS-COV-2 infection with neurological symptoms of demyelinating disease, even in the absence of relevant upper respiratory tract infection signs. | 2020-06-24 |
| 32564256 | Interestingly, mesenchymal stem cells (MSCs) can reduce inflammatory symptoms and protect against cytokine storm, which critically contributes to the COVID-19 progression. | 2020-06-24 |
| 32564270 | In contrast, it has also been hypothesized that overactive immune responses may trigger a cytokine storm associated with clinical deterioration, which has generated an interest in certain immunosuppressant drugs as potential treatment for COVID-19. […] The clinical picture was mild for which we have tried to provide an immunopathological framework. | 2020-06-24 |
| 32564376 | As fourth-year medical students in the UK who have had to adapt to working from home amidst nationwide cancellation of clinical placements, we read with interest Compton et al.’s survey assessing the prevalence of medical students’ preference for re-entering clinical environments during the COVID-19 pandemic1 . | 2020-06-21 |
| 32564384 | As U.K based medical students, we read with great interest the article by Compton et al 1 exploring the various factors influencing students’ motivation to return to clinical practice amidst the ongoing COVID-19 pandemic. […] Despite the study exploring several convincing factors in explaining the hesitance of medical students in returning to clinical placement, social vulnerability is often overlooked when explaining this reluctance. | 2020-06-21 |
| 32564416 | Taste and smell disorders have been reported along with various other clinical problems. | 2020-06-21 |
| 32564623 | In this review, we focus on potential druggable targets and suitable therapeutics, currently being explored in clinical trials, to treat SARS-CoV-2 infection. | 2020-06-25 |
| 32564974 | This study investigates the clinical characteristics and the risk factors for COVID-19 mortality and establishes a novel scoring system to predict mortality risk in patients with COVID-19. […] Demographic, clinical, and laboratory data on admission were collected from electronic medical records between January 14, 2020 and February 28, 2020. […] Clinical outcomes were collected until March 26, 2020. | 2020-06-25 |
| 32564984 | Our objective is to describe its clinical characteristics, the treatments and its clinical evolution. | 2020-06-25 |
| 32565030 | The lack of randomised clinical trials (RCTs) has led different countries to tackle the disease based on case series, or from results of observational studies with off-label drugs. | 2020-06-25 |
| 32565097 | To compare the clinical and laboratory features of severe acute respiratory syndrome 2003 (SARS) and coronavirus disease 2019 (COVID-19) in two Chinese pediatric cohorts, given that the causative pathogens and are biologically similar. […] Demographics, hospital length of stay, clinical and laboratory features were compared RESULTS: Overall, 97.7% of patients with SARS and 85.2% of patients with COVID-19 had epidemiological associations with known cases. | 2020-06-25 |
| 32565132 | Even though most people infected experience mild to moderate respiratory symptoms and recover with supportive care, certain vulnerable hosts develop severe clinical deterioration. […] While several drugs are currently being investigated in clinical trials, there are currently no approved treatments or vaccines for COVID-19 and hence there is an unmet need to explore additional therapeutic options. […] Specifically, Cytokine Release Syndrome (CRS), Immune Reconstitution Inflammatory Syndrome (IRIS), and Secondary Hemophagocytic Lymphohistiocytosis (sHLH) all have clinical and laboratory characteristics in common with COVID19 and associated therapies that could be worth testing in the context of clinical trials. […] We also discuss current cellular therapies that are being evaluated for the treatment of COVID-19 and/or its associated symptoms. | 2020-06-25 |
| 32565152 | Little information has been reported about the clinical characteristics of the patients. […] The major symptoms were cough and fever. | 2020-06-25 |
| 32565164 | Development of an online elective led to a 10-fold increase in student enrollment compared to the traditional course offering, providing a unique opportunity to reach a broad number of students, many of whom were in the early clinical stages of their medical school career. | 2020-06-24 |
| 32565226 | The early identification of patients at risk of clinical deterioration is of interest considering the timeline of COVID-19 after the onset of symptoms. […] The aim of our study was to evaluate the usefulness of testing serum IL-6 and other serological and clinical biomarkers, to predict a short-term negative clinical course of non critical COVID-19 patients. 208 patients with non critical COVID-19 pneumonia at admission were consecutively enrolled. […] Clinical and laboratory findings obtained upon admission were analyzed by using survival analysis and stepwise logistic regression for variable selection. […] Clinical worsening occurred in 63 patients (16=died; 39=transferred to Intensive Care Unit; 8 worsening of respiratory failure). […] The risk of clinical worsening was progressively enhanced along with increasing quartiles of IL-6 levels. […] Multivariate analysis showed that IL-6 (p=0.005), CRP (p=0.003) and SaO2/FiO2 (p=0.014) and were the best predictors for clinical deterioration in the first 3 days after admission. […] Combining IL-6, CRP and SaO2/FiO2 in a score, may help clinicians to identify upon admission those patients with COVID-19 who are at high risk for a further 3-day clinical deterioration. | 2020-06-24 |
| 32565242 | None of the otorhinolaryngologists involved in the procedures developed symptoms suggesting Covid-19 infestation. | 2020-06-27 |
| 32565306 | Clinical molecular laboratory professionals are at the frontline of the response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, providing accurate, high-quality laboratory results to aid in diagnosis, treatment, and epidemiology. | 2020-06-28 |
| 32565309 | This study aims to find a new antiviral combination regimen by investigating the frequency of clinically relevant and objectively identified comorbidities, and the clustering of these clinical syndromes and varying results of treatment with antiviral drugs in patients hospitalized with severe COVID-19. […] This study recruited 151 severe COVID-19 infection cases diagnosed in our hospital examination and illustrated the clinical potential during a consecutive 25-day medication period. […] Potential differences in disease severity and clinical characteristics, hematological profile, and current pharmacologic treatments (single agent, double or triple combinations, and the combined antiviral drugs plus Lianhua Qingwen) among comorbidity clusters were explored. […] Furthermore, explore clinical trials of variable antivirus treatments based on subgroup analyses or on using subgroups in the selection criteria would be the next step. | 2020-06-25 |
| 32565366 | Even in COVID-19 epidemics, the early identification of concurrent respiratory pathogens is important to improve etiological diagnosis, preventive measures and patients’ clinical management and outcome. | 2020-06-24 |
| 32565398 | In the absence of direct evidence examining efficacy of providing additional micronutrients or conditional amino acids to standard care, registered dietitian nutritionists must rely on clinical expertise and indirect evidence to guide medical nutrition therapy for patients infected with COVID-19. | 2020-06-25 |
| 32565483 | The primary outcomes will measure association between: (A) laboratory confirmed SARS-CoV-2 infection, morbidity and mortality, and demographic, socioeconomic and clinical population characteristics; and (B) healthcare burden of COVID-19 and demographic, socioeconomic and clinical population characteristics. | 2020-06-27 |
| 32565512 | This study aimed to determine the clinical significance of Krebs von den Lungen-6 (KL-6) in patients with COVID-19, so as to find a marker with high sensitivity, specificity and easy detection to evaluate the lung injury and inflammation of COVID-19. […] Sixty-three COVID-19 patients and 43 non-COVID-19 patients with similar clinical phenotypes and/or imaging findings were enrolled to test the levels of KL-6 using chemiluminescent immunoassay. | 2020-06-22 |
| 32565599 | The clinical characteristics of the disease range from asymptomatic cases or mild symptoms, which include nonspecific symptoms such as fever, cough, sore throat, headache, and nasal congestion to severe cases such as pneumonia, respiratory failure demanding mechanical ventilation to multi-organ failure, sepsis, and death. | 2020-06-23 |
| 32565678 | In health and medicine, people heavily use the Internet to search for information about symptoms, diseases, and treatments. | 2020-06-23 |
| 32565763 | From the clinical point of view, those infected have an average age of 55 years; the main symptoms are fever, dry cough, lymphopenia, dyspnea, and pneumonia in its severe form. | 2020-06-23 |
| 32565812 | This article provides a brief overview of the structure of the virus, modes of transmission, and clinical features of COVID-19 disease. | 2020-06-23 |
| 32565906 | The current pandemic due to the coronavirus disease 2019 (COVID-19) outbreak has forced physicians to review their current clinical practice and guidelines. | 2020-06-23 |
| 32565914 | The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide, with a vast majority of confirmed cases presenting with respiratory symptoms. | 2020-06-23 |
| 32565968 | We have outlined our clinical experience in managing patients with gastrointestinal, hematological, gynaecological, dermatological, neurological, thyroid, lung and paediatric cancers in the COVID-19 era and have reviewed the emerging literature around barriers to care of oncology patients and how this crisis affects them. | 2020-06-23 |
| 32566233 | We fitted different models using the clinical onset dates of patients with their close contact (infector-infectee). | 2020-06-23 |
| 32566261 | Experience gained in the development of vaccines for Ebola virus disease provide important lessons in the regulatory, clinical, and manufacturing process that can be applied to SARS-CoV-2 and other epidemic pathogens. | 2020-06-23 |
| 32566368 | There is a significant overlap between the clinical findings in novel coronavirus disease 2019 (COVID-19) and hemolysis, elevated liver enzymes, and low platelets syndrome (HELLP). Cases Patients presented at 22 and 29 weeks of gestation with suspected COVID-19 pneumonia. | 2020-06-23 |
| 32566425 | Initial stages of COVID-19 present with symptoms that mimic the common cold and individuals may be asymptomatic carriers and thus, transmitting the virus to others. […] Infected individuals presenting with mild to moderate symptoms are recommended to self-isolate as the majority will recover without any intervention. | 2020-06-23 |
| 32566429 | Although some antimalarial and antiviral drugs may prove effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), their safety and efficacy are still under clinical trials. […] We conducted a systematic review of case reports on ARDS in SARS-CoV-2 infection to summarize the clinical presentation, laboratory and chest imaging findings, management protocols, and outcome of ARDS in COVID-19-positive patients. | 2020-06-23 |
| 32566476 | The objective was to determine whether lower respiratory tract infection (LRTI), detected in bronchoalveolar lavage fluid (BALF), occurs in the absence of upper respiratory tract infection with clinical testing of both specimen types. […] In Case 1, negative NP testing occurred early in the infection and respiratory symptoms may have been missed due to neurologic injury. […] In Case 2, outpatient diagnosis was aspiration pneumonia, but clinical suspicion remained high for COVID-19 at hospitalization based on epidemiological and clinical features. | 2020-06-23 |
| 32566494 | Patients entering the hospital are screened for fever, travel history, contact and cluster history, and COVID-19 related symptoms. […] To protect and support hospital staff, we ensure provision of adequate personal protective equipment (PPE) and provide clear guidelines on the level of PPE needed, depending on the clinical situation. | 2020-06-23 |
| 32566557 | Clinicians need a more accurate understanding of the clinical characteristics of children with COVID-19. […] We searched studies reporting clinical characteristics in children with COVID-19 published until March 31, 2020. […] We combined some of the outcomes (symptoms) in a single-arm meta-analysis using a random-effects model. […] Our meta-analysis showed that most children with COVID-19 have mild symptoms. […] Eighty-three percent of the children were within family clusters of cases, and 19% had no symptoms. […] At least 7% with digestive symptoms. […] The main symptoms of children were fever [48%, 95% confidence interval (CI): 39%, 56%] and cough (39%, 95% CI: 30%, 48%). […] Most children with COVID-19 have only mild symptoms, and many children are asymptomatic. […] Fever and cough are the most common symptoms in children. | 2020-06-23 |
| 32566560 | Age and gender were not associated with clinical symptoms or the results of CT scan in children infected with SARS-CoV-2. […] The concentrations of white blood cells and neutrophils were higher in children with asymptomatic infection than in children with clinical symptoms or CT abnormalities. […] Patients who presented with CT abnormalities had lower D-dimer or lower total bilirubin than those who had normal CT scan but clinical symptoms. […] The mean duration of positive SARS-CoV-2 nucleic acid was 15.4 (SD =7.2) days and similar for both asymptomatic children and children with symptoms or CT abnormalities. […] The clinical significance and mechanism behind the negative correlation between the number of lymphocytes and the duration of positive SARS-CoV-2 needs further study. | 2020-06-23 |
| 32566561 | Electronic databases (MEDLINE, Embase, Web of Science, the Cochrane library, CBM, CNKI, and Wanfang Data) from their inception to March 31, 2020 were searched for randomized controlled trials (RCTs), clinical controlled trials and cohort studies of interventions with antiviral agents for children (less than 18 years of age) with COVID-19. […] There is no evidence showing the effectiveness of antiviral agents for children with COVID-19, and the clinical efficacy of existing antiviral agents is still uncertain. […] We do not suggest clinical routine use of antivirals for COVID-19 in children, with the exception of clinical trials. | 2020-06-23 |
| 32566562 | This rapid review aims to explore the clinical effectiveness and safety of IVIG in the treatment of children with severe COVID-19. | 2020-06-23 |
| 32566563 | We included studies about the content of the consultation (such as symptoms, therapy and prevention, policy, public service), screening of suspected cases, the provision of advice given to those people who may have symptoms or contact history. […] People were most concerned about symptoms (64.2%), epidemic situation and public problems (14.5%), and psychological problems (10.3%) during COVID-19 epidemic. […] During the SARS epidemic, the proportions of people asking for consultation for symptoms, prevention and therapy, and psychological problems were 35.0%, 22.0%, and 23.0%, respectively. […] Telemedicine services should focus on the issues that the public is most concerned about, such as the symptoms, prevention and treatment of the disease, and provide reasonable advice to patients with symptoms or people with epidemic history. | 2020-06-23 |
| 32566569 | The rapid emergence of clinical trials on COVID-19 stimulated a wave of discussion in scientific community. […] It is important to understand the characteristics of the ongoing or pending interventional clinical trials on COVID-19. […] We reviewed the characteristics of interventional trials from Chinese Clinical Trial Registration (ChiCTR) and ClinicalTrials.gov. […] Clinical trials on COVID-19 should be designed based on scientific rules, ethics and benefits for patients. | 2020-06-23 |
| 32566572 | An easy-to-use index capable of the early identification of inpatients who are at risk of becoming critically ill is urgently needed in clinical practice. | 2020-06-23 |
| 32566574 | The epidemiologic and clinical features as well as clinical outcomes were compared between the confirmed and suspected cases. […] The common onset symptoms of the patients in both groups were fever and cough. […] The disease onset of imported COVID-19 infection was occult, and the clinical symptoms were usually mild, mostly presenting as low fever, fatigue, light cough, and mild dyspnea. | 2020-06-23 |
| 32566579 | We aimed to describe the clinical characteristics of hospitalized patients with confirmed COVID-19 infection in Shaoxing, and provide an insight into the treatment of COVID-19 across China and elsewhere. […] Epidemiological, demographic, clinical, laboratory, radiological feature, and treatment data were all collected. […] The most common symptoms at onset of COVID-19 infection were fever [12 (75%)] and cough [8 (50%)]; 11 (68.8%) patients had lymphopenia, and 12 (75%) had elevated C-reactive protein. […] Compared with the symptoms of the initial patients with COVID-19 infection in Wuhan, the symptoms of the patients from Shaoxing city were relatively mild. | 2020-06-23 |
| 32566603 | To identify and treat the severe and critical patients with COVID-19 is the key clinical problem to be solved. […] The present study aimed to evaluate the clinical characteristics of severe and non-severe patients with COVID-19. […] We searched independently studies and retrieved the data that involved the clinical characteristics of severe and non-severe patients with COVID-19 through database searching. […] Severe patients with COVID-19 had more risk of clinical characteristics and multiple system organ complications. | 2020-06-23 |
| 32566620 | The clinical data of 45 moderate and severe type patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in Jingzhou Central Hospital from January 23 to February 13, 2020 were collected. […] The epidemiological indexes, clinical symptoms, and laboratory test results of the patients were retrospectively analyzed. […] The most common clinical symptoms were fever (89%) and dry cough (60%). | 2020-06-23 |
| 32566621 | The primary clinical outcome was the existence of acute respiratory distress syndrome (ARDS). | 2020-06-23 |
| 32566934 | The biological bases of immediate and new onset of psychiatric symptoms in individuals with COVID-19 are not yet known. […] We propose that both the (sub)chronic inflammatory response and cytokine storm might crucially be involved in the immediate manifestation of neuropsychiatric symptoms in individuals with COVID-19 infection as well as heightened expression of psychiatric symptoms in COVID-19 infected individuals with prior psychiatric conditions. | 2020-06-23 |
| 32567003 | The present study investigated the roles of hypoproteinemia in the clinical outcome and liver dysfunction of COVID-19 patients. […] The patients were divided into three groups-non-critically ill, critically ill, and death groups-in accordance with the Chinese Clinical Guideline for COVID-19. | 2020-06-25 |
| 32567006 | In the absence of a virus nucleic acid real-time reverse transcriptase-polymerase chain reaction (RT-PCR) test and experienced radiologists, clinical diagnosis is challenging for viral pneumonia with clinical symptoms and CT signs similar to that of coronavirus disease 2019 (COVID-19). | 2020-06-25 |
| 32567041 | They were contacted after the quarantine period to inquire about symptoms consistent with COVID-19, and the results of diagnostic test for SARS-CoV-2 when performed. […] One patient (0.7%) reported transient cough and sore throat, and the remaining 141 (99.3%) patients and 11 (100%) staff did not develop symptoms. | 2020-06-25 |
| 32567466 | Binary logistic regressions indicated employment status (odds ratio (OR) = 1.91; 95% confidence interval (CI): 1.072-3.418) and binge drinking (OR = 2.03; 95% CI: 1.045-3.945) were significantly associated with depressive symptoms; gender (OR = 2.17; 95% CI: 1.317-3.589), employment status (OR = 1.77; 95% CI: 1.002-3.141) and binge drinking (OR = 2.62; 95% CI: 1.361-5.048) were significantly associated with anxiety symptoms; and binge drinking (OR = 3.42; 95% CI: 1.544-7.583) was significantly associated with stress symptoms. | 2020-06-22 |
| 32567487 | In conclusion, it is proposed that these compounds are effective antiviral agents against COVID-19 and can be used in clinical trials.Communicated by Ramaswamy H. | 2020-06-22 |
| 32567505 | More data are needed to verify the correlation among immune response to SARS-CoV-2 infection, clinical evolution, and PET results. | 2020-06-25 |
| 32567580 | Many patients expressed symptoms of anxiety, although not depression. | 2020-06-22 |
| 32567656 | For healthcare providers, specifically military and federal public health personnel, prompt and accurate diagnosis and isolation of SARS-CoV-2 novel coronavirus patients provide a two-fold benefit: (1) directing appropriate treatment to the infected patient as early as possible in the progression of the disease to increase survival rates and minimize the devastating sequelae following recovery and remission of symptoms; (2) provide critical information requirements that enable commanders and public health officials to best synchronize policy, regulations, and troop movement restrictions while best allocating scarce resources in the delicate balance of risk mitigation versus mission readiness. | 2020-06-22 |
| 32567725 | Throughout the world, the public is being informed about the physical effects of SARS-CoV-2 infection and steps to take to prevent exposure to the coronavirus and manage symptoms of COVID-19 if they appear. […] As all efforts are focused on understanding the epidemiology, clinical features, transmission patterns, and management of the COVID-19 outbreak, there has been very little concern expressed over the effects on one’s mental health and on strategies to prevent stigmatization. | 2020-06-22 |
| 32567800 | Government guidelines and restrictions implemented to mitigate the risk of COVID-19 community transmission have forced radiation therapy departments to promptly adjust to the significant impact on our ability to deliver best clinical care. […] The aim of this paper is to describe the experience of the Peter MacCallum Cancer Centre’s (Peter Mac) radiation therapy services during the preliminary stages of the COVID-19 pandemic in minimising risk to patients, staff and our clinical service. […] Each of these initiatives had a focus on continuum of clinical care, whilst minimising risk of cross infection for our radiation therapy workforce and patients alike. […] Initiatives included, but were not limited to, establishing COVID-Eclipse clinical protocols, remote access to local applications, implementation of Microsoft Teams, personal protective equipment (PPE) guidelines and virtual ‘Division of Radiation Oncology’ briefing/updates. | 2020-06-22 |
| 32567823 | Since COVID-19 spread all over the world becoming a pandemic illness, researchers have better characterized route of virus transmissibility and clinical signs and symptoms of the disease. | 2020-06-22 |
| 32567938 | The virus binds to the cellular receptor ACE2, which in children has a structural and functional immaturity thus offering lower affinity to the pathogen; this could explain the lower incidence of infection from SARS-CoV-2 in this segment of the population.The common clinical observation is that COVID-19 is less severe in children, and in this group the disease is often asymptomatic. […] Pending further clinical studies able to clarify the infection and transmission dynamics, it is therefore important to apply also in children all preventive and hygiene measures recommended by the health authorities during dental treatment. | 2020-06-24 |
| 32567952 | After adjusting for demographic and community variables, quarantined respondents reported a higher likelihood to exhibit symptoms of depression and anxiety than those not quarantined. […] Respondents living in communities where screening for COVID-19 was required were less likely to report depression and anxiety symptoms.Conclusion: The incidence of depression and anxiety among quarantined respondents was significantly higher than that of respondents not quarantined, and twice as common among quarantined respondents in unaffected areas as those in affected areas. | 2020-06-22 |
| 32567972 | No drug has yet been approved for the treatment of SARS-CoV-2 infection; however, preclinical investigations suggested repurposing of several FDA-approved drugs for clinical trials. | 2020-06-25 |
| 32568102 | The clinical data for a 52-year-old male LBF patient were collected during the incubation period of COVID-19. […] The patient exhibited no obvious COVID-19-related symptoms prior to his surgery, and his vital signs were stable on the first day after the operation. | 2020-06-25 |
| 32568167 | How to objectively and quantitatively differentiate pneumonia patients with and without COVID-19 virus remains clinical challenge. […] To formulate standardized scoring criteria and an objective quantization standard to guide decision making in detection and diagnosis of COVID-19 virus induced pneumonia in clinical practice. | 2020-06-22 |
| 32568211 | Neuropsychiatric symptoms, such as depression, anxiety, apathy, agitation, and hallucinations, are frequent in Alzheimer’s disease (AD) and their prevalence tends to increase with external stressors. […] We offer the first investigation of the effects of confinement during the COVID-19 crisis on neuropsychiatric symptoms in patients with AD. […] We contacted caregivers of 38 patients with AD who were confined to their homes for nearly two months and asked them to report whether patients experienced any change in neuropsychiatric symptoms during, compared to before, the confinement and rate its severity and impact on themselves using the Neuropsychiatric Inventory-Questionnaire. […] Interestingly, among the 10 patients with neuropsychiatric changes, the duration of confinement significantly correlated with the severity of symptoms as well as with their caregivers’ distress. | 2020-06-22 |
| 32568341 | As a result, our fast and easy LFIAs could provide a preliminary test result for physicians to make the correct diagnosis of SARS-CoV-2 infections along with alternative testing methods and clinical findings, as well as seroprevalence determination, especially in low-resource countries. | 2020-06-22 |
| 32568434 | Here we describe the clinical presentations and outcomes of three teenagers with serologically-confirmed SARS-CoV-2 infection admitted to pediatric intensive care unit for PIMS-TS. | 2020-06-22 |
| 32568444 | Critical care management of patients with COVID-19 has been influenced by a mixture of public, media and societal pressure, as well as clinical and anecdotal observations from many prominent researchers and key opinion leaders. […] In this article, we analyse several potential iatrogenic causes of the detrimental effects of the current pandemic to children and highlight the risks underlying a sudden change of clinical practice. | 2020-06-22 |
| 32568496 | Active surveillance is the first choice of management and should be offered to all compliant clinical stage I TC patients provided they understand the need to self-isolate. | 2020-06-22 |
| 32568498 | The text also discusses new options such as telemedicine and what clinical situations within Female Urology should be of utmost importance for the urologist to be careful about. | 2020-06-22 |
| 32568662 | We evaluated the clinical course of asymptomatic and mildly symptomatic patients with laboratory-confirmed coronavirus disease (COVID-19) admitted to community treatment centers (CTCs) for isolation in South Korea. […] Of 632 patients, 75 (11.9%) had symptoms at admission, 186 (29.4%) were asymptomatic at admission but developed symptoms during their stay, and 371 (58.7%) remained asymptomatic during their entire clinical course. | 2020-06-22 |
| 32568663 | As a part of measures to decrease spikes in coronavirus disease (COVID-19) cases and deaths outside of hospitals, the government of South Korea introduced a plan for community treatment centers (CTCs) to isolate and monitor patients with mild COVID-19 symptoms. […] Because they offer appropriate clinical triaging and daily monitoring for patients, CTCs are a safe alternative to medical institutions for asymptomatic or mildly symptomatic patients with COVID-19. | 2020-06-22 |
| 32568665 | Most persons with confirmed coronavirus disease (COVID-19) have no or mild symptoms. […] SNUH converted an existing facility into a CTC to isolate patients who had confirmed COVID-19 but mild or no symptoms. […] Patients reported self-measured vital signs and symptoms twice a day by using a smartphone application. | 2020-06-22 |
| 32568722 | The novel coronavirus (severe acute respiratory syndrome coronavirus 2[SARS-CoV-2]) outbreak is now a pandemic, thousands of people now self-quarantined because of possible infection with the coronavirus, this situation makes telemedicine necessary as it can overcome geographical barriers, enlarge the size of the population served, and provide clinical support for patients online, however the outcomes of telemedicine have not yet evaluated. […] To describe the epidemiological features and clinical symptoms of patients receiving remote diagnosis and treatment at the online outpatient clinic of our hospital during the coronavirus disease 2019 (COVID-19) outbreak, and to analyze the outcomes and advantages of telemedicine during the COVID-19 pandemic. […] A retrospective analysis was performed on their epidemiological features, clinical symptoms, and preliminary outcomes. […] Based on the symptoms presented in the online outpatient consultation (one patient might be combined with more than one symptom), there were 2,383 patients with fever, 1,740 patients with cough, 796 patients with nasal obstruction, 503 patients with fatigue, and 276 patients with diarrhea. | 2020-06-22 |
| 32568725 | Compared with Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome, COVID-19 spreads more rapidly owing to increased globalization, longer incubation period, and unobvious symptoms. | 2020-06-22 |
| 32568727 | Most coronavirus disease 2019 (COVID-19) patients with mild symptoms were sent home for recovery. […] Through the comparison of monitored symptoms between hospitalized and non-hospitalized patients, this study found the prolonged persistence and deterioration of fever, dyspnea, lack of strength, and muscle soreness to be diagnostic for identifying patients for hospitalization. […] By continuously monitoring the changes of several key symptoms, the telemedicine system reduces the risks of delayed hospitalization for COVID-19 patients quarantined at home due to disease progression. | 2020-06-24 |
| 32568741 | COVID-19 is a disease with high mortality, and risk factors for worse clinical outcome have not been well-defined yet. […] Clinical characteristics, laboratory findings and outcomes data were obtained from electronic medical records. […] In-hospital clinical outcome was compared between patients with and without cardiac injury. […] Cardiac injury on admission is associated with worse clinical outcome and higher mortality risk in COVID-19 patients including patients free of previous CAD diagnosis. | 2020-06-22 |
| 32568770 | Leveraging data collected from electronic medical records for all patients hospitalized at NYU Langone Health with COVID-19 between March 2, 2020 and April 23, 2020, we matched 21 HIV-positive patients to 42 non-HIV patients using a greedy nearest neighbor algorithm. […] Other inflammatory markers did not differ significantly between groups, though HIV-positive patients tended to have higher peak values during their clinical course. | 2020-06-22 |
| 32568771 | We conducted a survey in Wuhan, China, to characterize the status of co-infected PLWH, their time to clinical improvement, and clinical prognoses. […] Nine of 10 persons on antiretroviral therapy (ART) presented with only mild COVID-19 symptoms. […] Excluding the deceased man, 6 of 11 co-infected persons reported feeling depressed even after clinical improvements. […] Two men identified as having started ART only recently were found to have severe symptoms. | 2020-06-22 |
| 32569013 | Clinical judgment should be utilized to evaluate the bleeding and safety risk of anticoagulation in COVID-19 patients without confirmed data. | 2020-06-22 |
| 32569196 | The clinical spectrum of SARS-CoV-2 infection appears to be wide, encompassing asymptomatic infection, mild upper respiratory tract illness, and severe viral pneumonia with respiratory failure and even death, with many patients being hospitalised with pneumonia. | 2020-06-22 |
| 32569204 | As a kind of representative of traditional Chinese medicine, the Chinese patent medicine injection has significant effect in reducing the clinical symptoms of patients and preventing the deterioration of the disease. […] The following electronic databases will be searched: PubMed, Web of Science, the Cochrane Library, EMBASE, China National Knowledge Infrastructure, Wanfang Database, Chinese Scientific Journal Database, Chinese Biomedical Literature database and some clinical trial registration websites. | 2020-06-22 |
| 32569358 | Large observational data networks that leverage routine clinical practice data in electronic health records (EHRs) are critical resources for research on COVID-19. […] In this study, we addressed the challenge of automating the normalization of COVID-19 diagnostic tests, which are critical data elements, but for which controlled terminology terms were published after clinical implementation. | 2020-06-22 |
| 32569374 | Most studies report a high prevalence of anxiety and depressive symptoms among HPs that can be associated with: a) COVID-19 exposure; b) epidemiological issues; c) material resources; d) human resources; and e) personal factors. | 2020-06-22 |
| 32569422 | The consensus to date is that most infants and children only have mild COVID-19 symptoms and few require intensive care. […] The girl only had mild respiratory symptoms and stayed 24-hours at the paediatric ward and was then cared for at home, but the boy required intensive care and invasive ventilatory support. | 2020-06-22 |
| 32569438 | These WEO recommendations are meant to guide endoscopists worldwide, should be interpreted in light of specific clinical conditions and resource availability and may not apply in all situations. | 2020-06-22 |
| 32569493 | Many scientific societies do not recommend discontinuing therapy in patients without symptoms or confirmation of SARS-CoV-2 infection despite the potentially higher risk of respiratory tract infections in this patient population. | 2020-06-26 |
| 32569494 | None of the patients reported ocular symptoms prior to systemic involvement. | 2020-06-22 |
| 32569585 | Clinical data were re-collected 10 min after prone positioning and 1 h after returning to the supine position. | 2020-06-25 |
| 32569635 | Consecutive detection of SARS-CoV-2 RNA from respiratory tract specimens is essential for determining duration of virus shedding and providing evidence to optimize the clinical management of COVID-19. […] The clinical characteristics of patients were recorded for further analysis. | 2020-06-24 |
| 32569708 | Human clinical trials are starting to show some results, in some cases like that of Remdesivir these are controversial. | 2020-06-28 |
| 32569833 | Clinical studies using the XPO1 inhibitor selinexor as a therapy for COVID-19 infection are in progress. | 2020-06-27 |
| 32569835 | We aimed to assess in this group the attack rate of asymptomatic carriers and the symptoms most frequently associated with the infection. […] Occupational and clinical characteristics of HCWs who performed a nasopharyngeal swab for the detection of SARS-CoV-2 in a University Hospital from February 24, to March 31, 2020, were collected. […] For those who tested positive and for the asymptomatic positives we checked laboratory and clinical data as of May 22 to calculate the time necessary to become test-negative and to verify whether symptoms developed thereafter. […] The likelihood of being positive increased with the number of reported symptoms and the strongest predictors were taste and smell alterations (odds ratio [OR]= 76.9) and fever (OR = 9.12). […] Among symptomatic workers, the key symptoms to guide diagnosis are taste and smell alterations and fever. | 2020-06-25 |
| 32569870 | Hence, clearly defined, science-based administrative, clinical, and physical measures are of paramount importance to eradicate the COVID-19 pandemic from the world. | 2020-06-26 |
| 32569879 | We also describe how these interactions see clinical relevance in several disorders where overactive complement results in a prothrombotic clinical presentation, and how it could be clinically relevant in COVID-19. | 2020-06-25 |
| 32569892 | In NSTEMI patients, 36.4% presented late (>24 hours of symptoms) during the COVID-19 pandemic in comparison with 2019 (27.1%, P = .033). | 2020-06-26 |
| 32570045 | This study provides a technical baseline of 13 different commercial PCR assays for SARS-CoV-2 detection that can be used by laboratories interested in purchasing any of these for further full clinical validation. | 2020-06-26 |
| 32570113 | Patients were categorized into 2 groups based on timing of developing neurological manifestations: the “Neuro first” group had neurological manifestations upon initial assessment, and the “COVID first” group developed neurological symptoms greater than 24 h after hospitalization. […] The demographics, comorbidities, disease severity and neurological symptoms and diagnoses of both groups were analyzed. […] Despite similar baseline comorbidities and demographics, the COVID-19 patients who developed neurologic symptoms later in hospitalization had more severe disease courses. | 2020-06-22 |
| 32570163 | Many researchers are currently evaluating the clinical characteristics of the SARS-CoV-2 reactivation. | 2020-06-26 |
| 32570166 | Adding these drugs to COVID-19 clinical trials may improve the patients’ outcomes. | 2020-06-26 |
| 32570168 | According to the American College of Cardiology Clinical Bulletin “COVID-19 Clinical Guidance for the CV Care Team”, there is a significantly higher fatality rate in people who are elderly (8.0% 70-79 years; 14.8% ≥80 years), diabetic (7.3%), hypertensive (6.0%), or have known cardiovascular disease (CVD) (10.5%). | 2020-06-26 |
| 32570240 | To date, the clinical characteristics of coronavirus disease 19 (COVID-19)-infected urologic cancer patients are unknown. […] Urgent intensive care unit admission was required due to clinical worsening. | 2020-06-22 |
| 32570265 | When integrated with clinical data, LUS could represent a valid diagnostic aid in patients with suspect COVID-19 pneumonia, which reflects CT findings. | 2020-06-22 |
| 32570284 | There were no symptoms of preeclampsia amongst the 34 pregnant women who had mild forms of COVID-19. | 2020-06-22 |
| 32570819 | The most requested information was the latest updated news on the epidemic, followed by information about disease symptoms and updated news on the outbreak. | 2020-06-25 |
| 32570882 | Current data suggest that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing corona virus disease-19 (COVID-19) seems to follow a more severe clinical course in patients with cardiovascular disease (CVD), hypertension, and overweight/obesity. | 2020-06-23 |
| 32570959 | The majority of pregnant women presented with mild to moderate symptoms, only 10 were admitted in the ICU, and one died. | 2020-06-23 |
| 32570995 | There is a hyperinflammatory response involved in the clinical course of patients with pneumonia due to SARS-CoV-2. | 2020-06-23 |
| 32571147 | Considerations of preventing SARS-CoV-2 transmission, conserving personal protective equipment, and prioritizing care delivery based on acuity have dictated clinical decision making in the acute phase of the pandemic. […] We share clinical cases that illustrate enduring principles of acute airway management. | 2020-06-23 |
| 32571228 | We aimed to recapitulate the clinical and CT imaging features of COVID-19 and their differences in three age groups. […] The clinical and CT data of patients with COVID-19 (n = 307) that had been divided into three groups (Group 1: < 40 years old; Group 2: 40 ≤ age < 60 years old; Group 3: ≥ 60 years old) according to age were analyzed retrospectively. […] COVID-19 presented representative clinical manifestations, laboratory examinations and CT findings, but three age groups possessed their own specific characteristics. […] Grasping the clinical and CT features stratified by age will be helpful for early definite diagnosis of COVID-19. | 2020-06-25 |
| 32571302 | Additionally, we assessed characteristics of clinical trials indexed in the WHO International Clinical Trials Registry Platform (WHO ICTRP) by April 7, 2020. | 2020-06-25 |
| 32571376 | The aim of this paper is to give a perspective on how to run a clinical service during an epidemic or pandemic emergency and to describe the potential COVID-19 associated risks for patients affected by inherited heart diseases. | 2020-06-25 |
| 32571410 | Patients’ symptoms, computer tomography (CT) images, preadmission drugs received, and the serum biochemical examination on admission were compared between the mild and severe groups. | 2020-06-25 |
| 32571455 | To study the clinical features of asymptomatic or subclinical coronavirus disease 2019 (COVID-19) in children. […] A retrospective analysis was performed for the clinical data of 53 children who were confirmed with asymptomatic or subclinical COVID-19, including epidemiological history, clinical typing, co-infection, time to clearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid in nasopharyngeal swabs, laboratory examination results, length of hospital stay, and treatment outcome. […] The children with asymptomatic or subclinical COVID-19 accounted for 30.5% (53/174) in children with COVID-19 hospitalized in the COVID-19 ward of Wuhan Children’s Hospital. […] Among the 53 children, 35 (66%) had asymptomatic infection and 18 (34%) had subclinical infection. […] Lung CT of 18 children with subclinical COVID-19 showed ground-glass opacities, linear opacities, and patchy opacities, with relatively limited lesions. […] There is a high proportion of children with asymptomatic or subclinical COVID-19 among the children with COVID-19 hospitalized in the COVID-19 ward. […] The transmission risk of asymptomatic or subclinical COVID-19 should be taken seriously. | 2020-06-25 |
| 32571605 | The clinical features and laboratory results of different age groups are different due to the general susceptibility of the disease. […] Para-clinical investigations including laboratory tests and radiologic findings play an important role in early diagnosis and treatment monitoring of COVID-19. […] The most attracting and reliable markers of COVID-19 in patients were: normal C-reactive protein (CRP) and very different and conflicting laboratory results regardless of clinical symptoms in neonates, normal or temporary elevated CRP, conflicting WBC count results and procalcitonin elevation in children, lymphopenia and elevated lactate dehydrogenase (LDH) in adult patients, lymphopenia and elevated CRP and LDH in the elderly people, leukocytosis and elevated neutrophil ratio in pregnant women. | 2020-06-25 |
| 32571606 | SARS-Cov-2, whose symptoms include difficulty swallowing, coughing, diarrhea, and breathing failure, has caused the loss of many lives around the world. | 2020-06-25 |
| 32571612 | The WHO has just released guidance for people in self-quarantine, those without any symptoms or diagnosis of acute respiratory illness, which provides practical advice on how to stay active and reduce sedentary behavior while at home. | 2020-06-25 |
| 32571616 | To estimate the prevalence of established diabetes and its association with the clinical severity and in-hospital mortality associated with COVID-19. | 2020-06-25 |
| 32571647 | We present the case of a 71-year-old man who, despite becoming asymptomatic after having some mild symptoms of COVID-19, had SARS-CoV-2 RNA detected for 37 days after onset, from his concentrated and purified saliva specimens using sugar chain-immobilized gold nanoparticles. | 2020-06-25 |
| 32571648 | Efforts to mitigate the spread of the virus through social distancing and shelter-at-home edicts have unintended consequences upon clinical and educational missions and mental well-being of radiology departments. […] An anonymous 22 question survey regarding the impact of COVID-19 pandemic on educational and clinical missions of residencies, its perceived impact upon morale of radiologists and trainees and a query of innovative solutions devised in response, was emailed to the Association of Program Directors in Radiology membership. | 2020-06-25 |
| 32571651 | Bedside chest ultrasonography, when integrated with clinical data, is an accurate tool for improving the diagnostic process of many respiratory diseases. […] A total of 83 older residents (age 85 ± 8) presenting mild to moderate respiratory symptoms and not previously tested for COVID-19, residing in 5 nursing homes in Northern Italy. […] The specialist team integrated ultrasonography data with clinical and anamnestic information, and gave personalized therapeutic advice for each patient, including hospital referral when needed. | 2020-06-25 |
| 32571677 | To establish efficient prevention and control measures, it is always necessary to implement contact tracing based on clinical suspicion, early diagnosis and isolation of cases and contacts and their follow-up. | 2020-06-25 |
| 32571730 | We present a case report of a 51-year-old man diagnosed with severe respiratory infection associated with SARS-CoV-2 that was refractory to antiviral and anti-IL-6 treatment, with a favourable clinical outcome and analytical improvement after treatment with anti-IL-1 (anakinra). | 2020-06-25 |
| 32571747 | Clinical and biological data (C-reactive protein serum level [CRP] and white blood cell count) of patients with CT findings suggestive for COVID-19 pneumonia were retrieved from the electronic medical chart. | 2020-06-25 |
| 32571748 | Lung disease extent on CT correlates with clinical severity. | 2020-06-25 |
| 32571783 | The comorbidities associated with obesity were found to be correlated with a severe clinical course of COVID-19 and increased mortality and high BMI has been shown to be correlated with hospitalisation, the need for mechanical ventilation and non-survival. | 2020-06-23 |
| 32571797 | The deletion of QTQTN was detected in 3 of 68 clinical samples and half of 24 in vitro isolated viruses, whilst the deletion of NSPRRAR was identified in 3 in vitro isolated viruses. […] Here, we identified two deletion variants of SARS-CoV-2 that either directly affect the furin-like cleavage site itself (NSPRRAR) or a flanking sequence (QTQTN) and investigated these deletions in cell isolates and clinical samples. | 2020-06-23 |
| 32571894 | This study compared 3 of these assays: the Hologic Panther Fusion SARS-CoV-2 assay (Fusion), the Hologic Aptima SARS-CoV-2 assay (Aptima) and the BioFire Defense COVID-19 test (BioFire), to determine analytical and clinical performance, as well as workflow. […] The clinical correlation found that the Fusion and BioFire assays had a positive percent agreement (PPA) of 98.7%, followed by the Aptima assay at 94.7% when compared to the consensus result. […] In addition, the Fusion and BioFire assays showed better clinical performance, while the Aptima assay showed a modest decrease in overall PPA. | 2020-06-23 |
| 32571972 | The aim of this study was to describe the demographic, baseline clinical characteristics and early outcomes of a European cohort of liver transplant recipients with SARS-CoV-2 infection. […] Baseline characteristics, clinical presentation, management of immunosuppressive therapy and outcomes were collected. 57 patients were included (70% male, median (IQR) age at diagnosis 65 (57-70) years). 21 (37%), 32 (56%) and 21 (37%) patients had one cardiovascular disease, arterial hypertension and diabetes mellitus, respectively. […] The most common symptoms were fever (79%), cough (55%), dyspnoea (46%), fatigue or myalgia (56%) and GI symptoms (33%). | 2020-06-26 |
| 32571980 | However, limited test availability, high false-negative rates, and the existence of asymptomatic or sub-clinical infections have resulted in an under-counting of the true prevalence of SARS-CoV-2. | 2020-06-23 |
| 32572128 | We conducted a clinical epidemiological analysis to investigate the association of overweight/obesity and abnormal liver function (ALF) with hospitalized duration in patients infected with COVID-19. […] Fifty-eight patients with diagnosed COVID-19 (22 women & 36 men; average age: 49.2 ± 13.1 yr) were included, and their clinical data were collected at The Second Affiliated and Yuying Children’s Hospital of Wenzhou Medical University, Zhejiang. […] Present findings suggested that overweight/obesity and/or ALF contributed to predicting a probability of prolonged hospitalization in patients with COVID-19 infection, to whom extra attentions and precautions should be paid during clinical treatments. | 2020-06-25 |
| 32572154 | Existing Clinical Laboratory Improvement Amendments regulations require pathologists to electronically verify patient reports from a certified facility. […] All glass slides representing routine clinical signout workload in surgical pathology subspecialties at Memorial Sloan Kettering Cancer Center were scanned on an Aperio GT450 at ×40 equivalent resolution (0.26 µm/pixel). […] Remote signouts utilized consumer-grade computers and monitors (monitor size, 13.3-42 in.; resolution, 1280 × 800-3840 × 2160 pixels) connecting to an institution clinical workstation via secure virtual private network. | 2020-06-27 |
| 32572155 | Since the outbreak of the COVID-19 pandemic, much has been learned regarding its clinical course, prognostic inflammatory markers, disease complications, and mechanical ventilation strategy. […] Here, we systematically reviewed published case reports and case series in order to increase our understanding of COVID-19 pathophysiology by constructing a timeline and correlating histopathological findings with clinical stages of COVID-19. […] These findings are consistent with knowledge regarding clinical patterns of viral infection, development of hyperinflammation and hypercoagulability, and fibrosis. […] Close collaboration among medical staff is necessary in order to translate this knowledge and classification of pathophysiological mechanisms into clinical stages of disease in individual patients. | 2020-06-25 |
| 32572174 | Three cardinal manifestations of neoplasia, namely inflammation, immune dysfunction, and coagulopathy are also seen in patients with severe SARS-CoV-2 infection, providing a biological rationale for testing selected anticancer drugs for their ability to control the symptoms and/or modify the course of COVID-19. | 2020-06-25 |
| 32572334 | Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appears with common symptoms including fever, dry cough, and fatigue, as well as some less common sysmptoms such as loss of taste and smell, diarrhea, skin rashes and discoloration of fingers. […] COVID-19 patients may also suffer from serious symptoms including shortness of breathing, chest pressure and pain, as well as loss of daily routine habits, pointing out to a sever reduction in the quality of life. | 2020-06-24 |
| 32572339 | The world has been challenged by SARS CoV-2, a new virus causing pneumonia and acute respiratory distress syndrome, with common symptoms of COVID-19 in pediatric patients including both respiratory and GI symptoms. […] Our case suggests that, in the current pandemic, consideration for SARS CoV-2 testing in children with gastrointestinal symptoms and pancreatitis may be considered. | 2020-06-24 |
| 32572350 | Alongside ICU nurses, physicians, and respiratory therapists, hospital pharmacists have been part of the COVID-19 efforts and their roles include management of drug shortages, development of treatment protocols, participation of patient rounds, interpretation of lab results for COVID-19, participant recruitment for clinical trials, exploration of new drugs, medication management advice, and antimicrobial stewardship. | 2020-06-24 |
| 32572363 | SARS-COVID-2 has been noted to be associated with neurological symptoms and complications including stroke. | 2020-06-24 |
| 32572532 | Classification of patients with influenza-associated pulmonary aspergillosis (IAPA) using the current definitions for invasive fungal diseases has proven difficult, and our aim was to develop case definitions for IAPA that can facilitate clinical studies. | 2020-06-25 |
| 32572561 | Of note, patients with abnormal imaging findings during the pandemic time had clinical data and/or laboratory tests negative for Covid-19 infection. | 2020-06-25 |
| 32572609 | We hypothesized that patients with rheumatic diseases (RD) would have increased psychological distress during the COVID-19 outbreak; therefore, assessed their psychological symptoms and changes in their routine. […] Female gender, use of social media, having a comorbid disease, or a psychiatric disorder were found to be independently associated with psychiatric symptoms in total study population. […] Psychiatric symptoms in patient’s and teacher’s populations were of considerable clinical concern, despite being significantly lower than that observed among the hospital workers. | 2020-06-26 |
| 32572616 | Clinical characteristics and laboratory results were compared between the groups. | 2020-06-25 |
| 32572835 | Various clinical presentations have been reported so far and no definite therapy is established. […] Anticoagulation is recommended by several experts to address the potential prothrombotic complications from COVID-19, but its safety and regimen need further clinical trials and safety and efficacy profile. | 2020-06-25 |
| 32573106 | Of the 90 patients who underwent NSI, 32 patients underwent ESS, while 58 patients had a significant enough improvement in symptoms to avoid ESS. | 2020-06-23 |
| 32573175 | The evidence-based suggestions provide the clinicians with current evidence and clinical experts opinion. […] This framework can be used to facilitate clinical decision making within the context of the individual patient. […] Further studies will evaluate the clinical usefulness of these suggestions. | 2020-06-26 |
| 32573207 | Analytical challenges directly impact the speed and validity of molecular diagnosis, raising concerns over clinical sensitivity and specificity. | 2020-06-23 |
| 32573254 | This article presents the experience of the clinical laboratory of Spedali Civili in Brescia (a teaching hospital in Lombardy with over 1500 beds) in managing the crisis, and to offer practical considerations for laboratory testing for this cohort of patients. | 2020-06-27 |
| 32573293 | We aimed to objectively assess the consequence of severe symptoms of Covid-19 infection on sleep quality through wrist actigraphy monitoring of four patients during the sub-acute recovery stage of the disease. […] The sleep of those patients who had experienced the most severe respiratory symptoms and who had needed prolonged intensive care unit (ICU) stay showed lower Sleep Efficiency and Immobility Time and higher Fragmentation Index compared to those patients who had experienced only mild respiratory symptoms and not requiring ICU stay. […] Wrist actigraphy assessment provided important clinical information about the sleep and activity levels of Covid-19 patients during the post-acute rehabilitation management. | 2020-06-23 |
| 32573297 | This review provides an overview and educational material on NAI and its clinical presentation.Methods - We combined a literature review with expert opinions of the senior authors into an educational paper aiming to help clinicians to recognize NAI and act appropriately by referral to multidisciplinary child protection teams and local authorities.Results - Despite the increased risk of NAI during the current COVID-19 crisis, the number of reports suspecting NAI decreased by 42% during the lockdown of the Danish society. […] Interpretation - The key to recognizing and suspecting NAI upon clinical presentation is to be aware of inconsistencies in the medical history and suspicious findings on physical and paraclinical examination. | 2020-06-24 |
| 32573353 | We aimed to describe epidemiological features and clinical course in a large urban center to inform prevention and treatment of imported epidemics. Methods We retrospectively analyzed data collected at Shanghai Public Health Clinical Center, between January 20 and February 29, 2020. Results Among 325 cases admitted, median age was 51 years and 47.4% (154/325) had visited Wuhan within 2 weeks of illness onset. | 2020-06-23 |
| 32573355 | It is concluded that Raltegravir and Maraviroc which may be used in the treatment of COVID-19 after Invitro and invivo studies and clinical trial for final confirmation of drug effectiveness.Communicated by Ramaswamy H. | 2020-06-25 |
| 32573419 | Patients with increasing O2 requirements, within the window of opportunity for TCZ treatment (Day 7 to Day 17 after onset of symptoms) were treated with TCZ (2 infusions of 8 mg/kg). […] Demographic, biological and clinical data were collected from the patients’ files. | 2020-06-23 |
| 32573550 | However, despite a constant and wide-ranging editorial production and fruitful collaborations with colleagues and institutions at national and international level, the orthopaedic scientific community finds it difficult to recognize the EBM model as a solid reference: there are few guidelines available, there is little awareness of their usefulness, and the complexity of the methodology of production and adaptation of documents widens the gap between the orthopaedic real world and that of clinical epidemiology. | 2020-06-26 |
| 32573551 | This document is intended for all healthcare professionals caring for CoViD-19 patients, particularly those in more severe clinical conditions and it is aimed to help the care team to communicate with families distanced from the patient. | 2020-06-26 |
| 32573724 | To comprehensively evaluate the effectiveness, safety, and indications of convalescent plasma transfusion (CPT) therapy for severe or critical COVID-19 patients, we analyzed the clinical, laboratory, and radiologic characteristics of 1,568 patients from a single center, in which 138 patients received ABO-compatible CPT. […] 2.4% and 5.1% of patients in the CPT and the standard-treatment group have been admitted to ICU eventually. 70% of the patients who had severe respiratory symptoms got improved and removed oxygen supports within 7 days after CPT. […] Notably, for the patients who received CPT within 7 weeks after symptom onset, the median time from CPT to clinical improvements was approximately 10 days. […] But the time to clinical improvements was significantly prolonged for patients who received CPT later than 7 weeks after onset. […] Our study will provide important information for the clinical practice in COVID-19 treatment, as well as provide real-world observations and clinical data for the development of monoclonal antibodies. | 2020-06-23 |
| 32573773 | At the start of the pandemic, in a single week, our medical communities, both in primary care , nursing homes, as in secondary and tertiary facilities have been forced to stop all regular clinical care and to shift towards hospital care that was ultimately restricted to Covid-19 related disease. […] The clinical presentation of Covid-19 occurred predominantly in the elderly patients (most > 65 years old) displaying a respiratory disability, and in a small proportion among them displayed a respiratory failure, in association with a broad range of pre-existing co-morbidities. | 2020-06-23 |
| 32573776 | The authors conducted a multicenter retrospective study to investigate the clinical manifestations and outcomes of patients with cancer who are diagnosed with COVID-19. […] The authors reviewed the medical records of hospitalized patients who were treated at 5 hospitals in Wuhan City, China, between January 5 and March 18, 2020. […] Clinical parameters relating to cancer history (type and treatment) and COVID-19 were collected. […] Secondary analyses were the association between clinical factors and severe COVID-19 and OS. | 2020-06-23 |
| 32573788 | The knowledge of the tissue distribution of ACE2 in human organs is therefore important to predict the clinical course of the COVID-19. | 2020-06-23 |
| 32573882 | Clinical presentation of flu-like symptoms was similar to those in the general population. | 2020-06-23 |
| 32573895 | In this report we describe the clinical data, the treatments and the outcomes of 5 KTRs with SARS-CoV-2 admitted to our hospital in Ancona, Marche region, Italy, from March, 17 to present. […] Thus, in SARS-CoV-2 affected KTRs a close biochemical and clinical monitoring should be set up to allow physicians to hit the virus in the right moment such as a sudden reduction of the oxygen saturation and/or a significant increase of the laboratory values such as D-Dimer. | 2020-06-23 |
| 32573990 | He was treated with tocilizumab with symptoms improvement, without a complete pulmonary function recovery. | 2020-06-23 |
| 32573995 | Demographical, clinical and laboratory data were collected upon hospital admission and were then correlated with outcome (i.e. in-hospital death vs. discharge). […] Conclusions The most important laboratory abnormalities described here in a subset of European COVID-19 patients residing in Valcamonica are highly predictive of in-hospital death and may be useful for guiding risk assessment and clinical decision-making. | 2020-06-24 |
| 32574107 | As healthy young adults can die of COVID-19, whereas old COVID-19 patients can have mild symptoms only, genetic variances probably contribute to the severity of this emerging infection. | 2020-06-23 |
| 32574109 | Specifically, we review the potential clinical utility of two transmembrane serine protease 2 (TMPRSS2)-targeting protease inhibitors, nafamostat mesylate and camostat mesylate, as well as two novel potent fusion inhibitors and the repurposed Ebola drug, remdesivir, which is specific to RdRp, against human coronaviruses, including SARS-CoV-2. | 2020-06-25 |
| 32574131 | Clinical research and scientific activities were reduced in 80.3% and 80.1% of respondents previously implicated in these activities, respectively. | 2020-06-23 |
| 32574165 | To limit the spread of SARS-CoV-2, an evidence-based understanding of the symptoms is critical to inform guidelines for quarantining and testing. […] The most common features are purported to be fever and a new persistent cough, although the global prevalence of these symptoms remains unclear. […] The aim of this systematic review is to determine the prevalence of symptoms associated with COVID-19 worldwide. […] A random-effects model for pooling of binomial data was applied to estimate the prevalence of symptoms, subgrouping estimates by country. […] The most prevalent symptoms were fever (78% [95% CI 75%-81%]; 138 studies, 21,701 patients; I2 94%), a cough (57% [95% CI 54%-60%]; 138 studies, 21,682 patients; I2 94%) and fatigue (31% [95% CI 27%-35%]; 78 studies, 13,385 patients; I2 95%). […] We confirm that fever and cough are the most prevalent symptoms of adults infected by SARS-CoV-2. […] However, there is a large proportion of infected adults which symptoms-alone do not identify. | 2020-06-26 |
| 32574235 | Development of a core outcome set (COS) for clinical trials for COVID-19 is urgent because of the pandemic wreaking havoc worldwide and the heterogeneity of outcomes in clinical trials. […] A preliminary list of outcomes was developed after a systematic review of protocols of clinical trials for COVID-19. […] Ninety-seven eligible study protocols were identified from 160 clinical trials. […] Seventy-six outcomes were identified from TCM clinical trials and 126 outcomes were identified from WM clinical trials. […] Then, a COS for clinical trials of TCM and WM was developed. […] The COS included clinical outcomes (recovery/improvement/progression/death), etiology (SARS-CoV-2 nucleic-acid tests, viral load), inflammatory factor (C-reactive protein), vital signs (temperature, respiration), blood and lymphatic-system parameters (lymphocytes, virus antibody), respiratory outcomes (pulmonary imaging, blood oxygen saturation, PaO2/FiO2 ratio, arterial blood gas analysis, mechanical ventilation, oxygen intake, pneumonia severity index), clinical efficacy (prevalence of preventing patients with mild-to-moderate disease progressing to severe disease), and symptoms (clinical symptom score). […] Though there are some limitations for the research, such as insufficient patients and the public involvement, and the unbalanced stakeholders’ region, the COS for COVID-19 may improve consistency of outcome reporting in clinical trials. | 2020-06-23 |
| 32574236 | Everybody is waiting the findings of ongoing clinical trials in various chemical and biological products. […] This review is specifically aimed to summarize the available evidence and ongoing clinical trials of remdesivir as a potential therapeutic option for COVID-19. […] Of which, one completed double blind, placebo controlled trial showed that remdesivir showed faster time to clinical improvement in severe COVID-19 patients compared to placebo though not found statistically significant. […] In addition, two phase 3 randomized open label clinical trials coordinated by Gilead Sciences are being conducted. | 2020-06-23 |
| 32574237 | Adaptive clinical trials with parallel enrollment to different arms each evaluating a rationally designed combination modality could provide the foundation for the accelerated identification of effective and safe multi-modality treatment algorithms for COVID-19 pneumonia. […] This article summarizes the insights and lessons learned from clinical immune-oncology trials as well as lung transplantation that are informing the clinical development of promising new strategies aimed at reducing the fatality rate in COVID-19. | 2020-06-23 |
| 32574243 | This body of evidence may be useful for helping bereaved people during the acute phase of the COVID-19 pandemic and for drawing clinical attention to people at risk for CG. | 2020-06-23 |
| 32574245 | Patients with severe symptoms of COVID-19 may also present with acute neurological emergencies such as ischemic stroke. […] It is recommended to perform MT in patients within the established guidelines, and consider a conservative approach in cases where there is clinical equipoise to minimize futile reperfusion. | 2020-06-23 |
| 32574246 | Objective: Review and integrate the neurologic manifestations of the Coronavirus Disease 2019 (COVID-19) pandemic, to aid medical practitioners who are combating the newly derived infectious disease. Methods: We reviewed the clinical research, consisting of mainly case series, on reported neurologic manifestations of COVID-19. […] We also reviewed basic studies to understand the mechanism of these neurologic symptoms and signs. Results: We included 79 studies for qualitative synthesis and 63 studies for meta-analysis. | 2020-06-23 |
| 32574247 | Some patients also experience neurological signs and symptoms ranging from anosmia, ageusia, headache, nausea, and vomiting to confusion, encephalitis, and stroke. | 2020-06-23 |
| 32574248 | Background: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with many neurological symptoms but there is a little evidence-based published material on the neurological manifestations of COVID-19. […] The purpose of this article is to review the spectrum of the various neurological manifestations and underlying associated pathophysiology in COVID-19 patients. Method: We conducted a review of the various case reports and retrospective clinical studies published on the neurological manifestations, associated literature, and related pathophysiology of COVID-19 using PUBMED and subsequent proceedings. […] Every article was either based on descriptive analysis, clinical scenarios, correspondence, and editorials emphasizing the neurological manifestations either directly or indirectly. […] With little known about the dynamics and the presentation spectrum of the virus apart from the respiratory symptoms, this area needs further consideration. Conclusion: The neurological manifestations associated with COVID-19 such as Encephalitis, Meningitis, acute cerebrovascular disease, and Guillain Barré Syndrome (GBS) are of great concern. | 2020-06-23 |
| 32574249 | We aim to analyze the effect of COVID-19 pandemic and social restriction rules on these fragile patients. Methods: Patients with chronic neurologic diseases routinely followed at the outpatient clinic of Gemelli University Hospital, Rome, were assessed for symptoms suggestive of SARS-CoV-2 infection in the pandemic period, consequences of social restrictions, and neurological disease features, concomitant medical conditions, current medical and disease-specific treatments. […] Data source: a dedicated telephone survey designed to encompass questions on COVID-19 symptoms and on pandemic effects in chronic neurologic conditions. Results: Overall, 2,167 individuals were analyzed: 63 patients reported contact with COVID-19 positive cases, 41 performed the swab, and 2 symptomatic patients tested positive for COVID-19 (0.09%). […] One hundred fifty-eight individuals (7%) needed urgent neurological care, deferred due to the pandemic; 641 patients (30%) suspended hospital treatments, physiotherapy or other support interventions; 405 individuals (19%) reported a subjective worsening of neurological symptoms. Conclusions: In our population, the presence of neurological chronic diseases did not increase the prevalence of COVID-19 infection. | 2020-06-23 |
| 32574250 | The presenting symptoms are mainly respiratory symptom, yet studies have reported nervous system involvement in the disease. […] Underlying cerebrovascular disease was found in 8.5% (95%CI 4.5-13.5%) of the studies. Conclusion: Neurologic findings vary from non-specific to specific symptoms in COVID-19 patients. […] Some severe symptoms or diseases can present in the later stage of the disease. […] Physicians should be aware of the presence of neurologic signs and symptoms as a chief complaint of COVID-19, in order to improve management and prevent a worsening outcome of the patients. | 2020-06-23 |
| 32574255 | However, limited data are available for the clinical course and management of COVID-19 in pregnancy. […] We compared the clinical course and outcomes of COVID-19, SARS, and MERS in pregnancy and discussed several drugs for the treatment of COVID-19 in pregnancy. | 2020-06-23 |
| 32574260 | In addition, potential treatments currently under clinical trials focusing on killing coronaviruses or on developing vaccines preventing coronavirus infection largely ignore the host immune response. […] Therefore, further understanding of the host immune response to SARS-CoV-2 is extremely important for clinical resolution and saving medication cost. | 2020-06-26 |
| 32574261 | A great variety of symptoms associated with COVID-19 disease, ranging from mild to severe symptoms, eventually leading to death. | 2020-06-26 |
| 32574263 | Numerous clinical trials of mesenchymal stromal/stem cells (MSCs) as a new treatment for coronavirus-induced disease (COVID-19) have been registered recently, most of them based on intravenous (IV) infusion. […] In contrast, well-characterized products with robust manufacturing procedures and optimized modes of clinical delivery hold great promise for ameliorating COVID-19 by exerting their beneficial immunomodulatory effects, inducing tissue repair and organ protection. […] We here propose three steps to mitigate the risk for these vulnerable patients: (1) updated clinical guidelines for cell and tissue transplantation, (2) updated minimal criteria for characterization of cellular therapeutics, and (3) updated cell therapy routines reflecting specific patient needs. | 2020-06-26 |
| 32574265 | Here we review possible life-threating immune events that can occur during disease progression to uncover key factors behind COVID-19 severity and provide suggestions for interventions with repurposed drugs in well-controlled and randomized clinical trials. | 2020-06-26 |
| 32574268 | The majority of infected people presents flu like symptoms and among them 15-20% develops a severe interstitial pneumonitis (IP) that may eventually evolve in acute respiratory distress syndrome (ARDS). […] Cytokines and other molecules involved in immune response and inflammation are conceivable therapeutic targets for IP and ARDS, improving symptoms and decreasing intensive care unit admissions. […] Some off label therapeutic options and preclinical evidence drugs are herein considered. | 2020-06-26 |
| 32574274 | Based on just one-case report that presented positive outcomes in a patient treated amongst others with Thalidomide, two clinical trials on the efficacy and safety of Thalidomide in treating severe respiratory complications in COVID-19 patients were registered. […] Yet, the absence of substantial evidence on Thalidomide usage in that context along with the discontinued studies on the efficiency of this drug in similar pulmonary diseases, might cause a significant obstacle for carrying out further clinical evaluations. | 2020-06-26 |
| 32574282 | The clinical characteristics of these 53 patients were collected and compared based on a positive RT-PCR test and presence of pneumonia. […] Clinical data showed that 47.2% (25/53) of COVID-19 patients were co-infected with Mycoplasma pneumoniae, and COVID-19 patients coinfected with M. pneumoniae had a higher percentage of monocytes (P < 0.0044) and a lower neutrophils percentage (P < 0.0264). | 2020-06-26 |
| 32574284 | Five patients with non-respiratory symptoms as the first manifestation were hospitalized from the emergency department, and were later confirmed to have COVID-19, between 23 January and 20 February 2020, at the Wuhan Children’s Hospital. […] This case series is the first report to describe the clinical features of COVID-19 with non-respiratory symptoms as the first manifestation in children. | 2020-06-23 |
| 32574285 | The disease, named COVID-19, has a wide spectrum of clinical presentations, ranging from asymptomatic or mild to critical, and for some patients the disease is even fatal. […] In all case reports and case series, the mothers’ infection occurred in the third trimester of pregnancy, there were no maternal deaths, and most neonates had a favorable clinical course. | 2020-06-23 |
| 32574287 | The information about its clinical features, laboratory findings and prognosis in children and newborns is scarce. […] Suspected or proven cases of newborns with symptoms should be quarantined in the neonatal intensive care unit for at least 14 days with standart and droplet isolation precautions. | 2020-06-23 |
| 32574292 | This article reviews the epidemiology, pathogenesis, clinical manifestations, diagnosis, and treatment methods of severe COVID-19 and puts forward some tentative ideas, aiming to provide some guidance for the diagnosis and treatment of severe COVID-19. | 2020-06-23 |
| 32574293 | We selected COVID-19 observational studies from eight countries, including, China, Italy, Australia, Canada, Korea, Taiwan, Singapore, and the USA, comprising a total of 13 studies and performed a meta-analysis for age, gender, fatality rate, and clinical symptoms of fever, cough, shortness of breath, and diarrhea. […] The meta-analysis shows that there are differences in symptoms and other characteristics reported by the patients of COVID-19 inside and outside China. […] However, we found the opposite results for the gastrointestinal symptoms such as Diarrhea. […] These findings also suggest that the clinical symptoms of COVID-19 should not be generalized to fever, shortness of breath, and cough only but other symptoms such as diarrhea are also prevalent in patients with COVID-19. | 2020-06-23 |
| 32574296 | We searched PubMed and Google Scholar for studies published from December 2019 to March 31, 2020 with the terms “COVID-19,” “2019-nCoV,” “SARS-CoV-2,” or “Novel Coronavirus Pneumonia.” The main symptoms of COVID-19 are fever (83-98.6%), cough (59.4-82%), and fatigue (38.1-69.6%). | 2020-06-23 |
| 32574297 | Introduction: Influenza virus pneumonia and COVID-19 are two different types of respiratory viral pneumonia but with very similar clinical manifestations. […] The aim of the present study was to help clinicians gain a better understanding about differences between Influenza virus pneumonia and COVID-19 by comparative analysis of the early-stage clinical features. Methods: Clinical data of patients with confirmed diagnosis of COVID-19 and influenza A pneumonia identified in our hospital were collected and analyzed retrospectively to identify the clinical features that could differentiate between the two types of viral pneumonia. Results: The two types of viral pneumonia mainly affected adults, especially people over 50 years, with no gender difference between them. […] Fever, cough, sputum and muscle soreness were the most common symptoms of COVID-19. […] Some patients with COVID-19 may also exhibit digestive tract symptoms. […] The grid-form shadow was a typical presentation of COVID-19 on the lung CT image, and the disease usually progressed quickly within a week. Conclusion: Influenza pneumonia and COVID-19 are two different types of respiratory viral pneumonia with very similar clinical manifestations. | 2020-06-23 |
| 32574308 | We performed a study of patients presenting olfactory/gustatory alterations in the context of SARS-CoV-2 infection in order to contribute to the understanding of this phenomenon. Material and Methods: We performed a descriptive, cross-sectional, observational study of the clinical characteristics of olfactory/gustatory alterations using a self-administered, anonymous online questionnaire. Results: A total of 909 patients with SARS-CoV-2 infection and olfactory/gustatory alterations responded to the questionnaire in the 4-day data collection period; 824 cases (90.65%) reported simultaneous olfactory and gustatory involvement. | 2020-06-23 |
| 32574309 | Objectives: To study in-depth the clinical and epidemiological characteristics of pneumonia resulting from COVID-19 and provide evidence for effective public health decisions. Methods: This was a retrospective, single-center research study. […] A difference in C-reactive protein levels between severe and critical groups was also found (P < 0.05). Conclusions: In the majority of cases no gender differences were observed and mostly the symptoms were mild. | 2020-06-23 |
| 32574310 | Clinical and laboratory data were collected with standardized forms. Results: A total of 164 subjects were included in this study, 82 cases in the infected group and 82 controls in the uninfected group, with a median age of 37 years, including 63 males and 101 females. […] Thirty-four patients (41.5%) with mild symptoms were treated outside the hospital, among which the median age was 34 (30-39) years, and twelve patients (35.3%) took prophylactic oral arbidol. | 2020-06-23 |
| 32574312 | Benefits of chloroquine and hydroxychloroquine for the treatment of COVID-19 infection have been proposed and clinical trials are underway. […] Clinical trials of chloroquine or hydroxychloroquine should also consider including audiological monitoring in the protocol. | 2020-06-23 |
| 32574314 | The survey was structured to assess their knowledge about viral sources, incubation period, mortality rate, transmission, symptoms and complications as well as the source of information about COVID-19. Results:Overall, 56.5% of the respondents showed good knowledge and almost 40.5% showed moderate knowledge. | 2020-06-23 |
| 32574315 | One model to forecast disease spread depends on clinical parameters and transmission rates. | 2020-06-23 |
| 32574317 | In this review article, we outline the mechanisms of cytokine storm and lung damage caused by SARS-CoV-2 virus leading to COVID-19 disease and how mesenchymal stem cells (MSCs) and their secreted EVs can be utilized to tackle this damage by harnessing their regenerative properties, which gives them potential enhanced clinical utility compared to other investigated pharmacological treatments. […] There are currently 17 clinical trials evaluating the therapeutic potential of MSCs for the treatment of COVID-19, the majority of which are administered intravenously with only one clinical trial testing MSC-derived exosomes via inhalation route. | 2020-06-23 |
| 32574318 | Clinical signs, treatment, and prevention characteristics of the novel coronavirus pneumonia have been receiving attention worldwide, especially from medical personnel. […] This review combines experimental and clinical evidence into a systematic analysis and summary of the current progress of research into SARS-CoV-2, from multiple perspectives, with the aim of gaining a better overall understanding of the disease. | 2020-06-23 |
| 32574321 | We sought to delineate the time features of clinical symptoms, virological conversion, and chest radiological abnormalities in individuals infected with this virus in Zhuhai, China. Methods: In this retrospective study, we assessed 85 confirmed cases of COVID-19 in the Fifth Hospital of Sun Yat-sen University, Zhuhai, from the 17th of January to the 11th of February 2020. | 2020-06-23 |
| 32574322 | Objective: This study aimed to identify additional characteristics and features of coronavirus disease (COVID-19) by assessing the clinical courses among COVID-19 patients in a region outside Hubei province. Methods: We analyzed retrospective data regarding general characteristics, epidemiologic history, underlying chronic diseases, clinical symptoms and complications, chest computed tomography findings, biochemical monitoring, disease severity, treatments, and outcomes among 37 adult patients with COVID-19. […] The main symptoms were cough (67.6%), fever (62.2%), shortness of breath (32.4%), fatigue (24.3%), sore throat (21.6%), vomiting, and diarrhea (21.6%). […] When the 37 patients were released from quarantine, the white blood cell count of 16.2% of the patients was <4.0 × 109/L, the lymphocyte count of 59.5% of the patients was <1.1 × 109/L, and the absolute counts of white blood cells and lymphocytes were 5.02 ± 1.34 × 109/L and 1.03 ± 0.34 × 109/L, respectively, compared with those recorded on admission (P > 0.05). Conclusion: The majority of COVID-19 cases in the study area were mild and moderate, with good clinical outcomes. […] There were some special characteristics in the clinical course. | 2020-06-23 |
| 32574326 | Introduction: COVID-19 Ag Respi-Strip, an immunochromatographic (ICT) assay for the rapid detection of SARS-CoV-2 antigen on nasopharyngeal specimen, has been developed to identify positive COVID-19 patients allowing prompt clinical and quarantine decisions. […] In this original research article, we describe the conception, the analytical and clinical performances as well as the risk management of implementing the COVID-19 Ag Respi-Strip in a diagnostic decision algorithm. Materials and Methods: Development of the COVID-19 Ag Respi-Strip resulted in a ready-to-use ICT assay based on a membrane technology with colloidal gold nanoparticles using monoclonal antibodies directed against the SARS-CoV and SARS-CoV-2 highly conserved nucleoprotein antigen. […] The clinical performance study was performed in a retrospective multi-centric evaluation on aliquots of 328 nasopharyngeal samples. […] In the clinical performance study performed in three different clinical laboratories during the ascendant phase of the epidemiological curve, we found an overall sensitivity and specificity of 57.6 and 99.5%, respectively with an accuracy of 82.6%. […] User-friendliness analysis and risk management assessment through Ishikawa diagram demonstrate that COVID-19 Ag Respi-Strip may be implemented in clinical laboratories according to biosafety recommendations. Conclusion: The COVID-19 Ag Respi-Strip represents a promising rapid SARS-CoV-2 antigen assay for the first-line diagnosis of COVID-19 in 15 min at the peak of the pandemic. | 2020-06-23 |
| 32574328 | The objective of this systematic review was to characterize the clinical, diagnostic, and treatment characteristics of hospitalized patients presenting with COVID-19. Methods: We conducted a structured search using PubMed/Medline, Embase, and Web of Science to collect both case reports and case series on COVID-19 published up to April 24, 2020. […] Other symptoms including rhinorrhea, dizziness, and chills were less frequently reported. […] Early detection of elevations in serum CRP, combined with a clinical COVID-19 symptom presentation may be used as a surrogate marker for the presence and severity of the disease. | 2020-06-23 |
| 32574333 | In this article, we present the developments from the first to seventh versions, involving changes of case classification, changes to “suspected case,” changes in “confirmed case,” changes in clinical classifications, changes in “severe case,” and unchanged criteria. | 2020-06-23 |
| 32574334 | Briefly, we compared the dynamic profile of biochemical and immune parameters and drew an epidemiological and clinical picture of disease progression from disease onset to death in non-survivors. | 2020-06-23 |
| 32574336 | Clinical trials are underway to test the risks and benefits of ARBs and angiotensin-converting enzyme inhibitors (ACEIs) in COVID-19 patients requiring hospitalization. | 2020-06-23 |
| 32574337 | This paper reports the clinical characteristics, diagnosis, and treatment of the first critical COVID-19 patient in Liaocheng City, who was admitted to the intensive care unit isolation ward of Liaocheng People’s Hospital on February 11, 2020. […] The purpose of this case report is to provide a reference for the clinical diagnosis and treatment of critical COVID-19 patients. | 2020-06-23 |
| 32574340 | The effects of CHM in COVID-19 may be clinically important and warrant further consideration and studies. Clinical Trial Registration: http://www.chictr.org.cn/index.aspx. | 2020-06-23 |
| 32574433 | Patients’ self-reported symptoms, daily mean SpO2 (SO2), arterial blood gas analysis, D-dimer, lymphocyte, cholinesterase (che) and chest CT were conducted and measured. […] It requires evaluation in randomized clinical trials in future. | 2020-06-23 |
| 32574446 | Questions have been raised pertinent to two possible mechanisms for HBO2 in this clinical context. | 2020-06-23 |
| 32574555 | Analysis of the International Society for Stem Cell Research (ISSCR) member survey has highlighted a particular impact on clinical trials and early-career investigators. | 2020-06-25 |
| 32574694 | The severity of lung lesions predicts poor clinical outcomes and may be a predictor of the transition from mild to severe. | 2020-06-25 |
| 32574697 | We review the evolution of our clinical understanding of COVID-19, possible therapeutic targets, and prospects for COVID-19 management. | 2020-06-25 |
| 32574840 | The clinical management of COVID-19 is dependent on understanding the underlying factors that contribute to the disease severity. […] The data for patients were available including the onset of the disease, duration of viral persistence, measurements of inflammatory markers such as IL-6 and CRP, chest imaging, disease symptoms, and their durations among others. | 2020-06-25 |
| 32574871 | Although this infection at the early stage creates seasonal flu-like symptoms with a higher illness, it eventually causes a higher mortality. | 2020-06-25 |
| 32574896 | The aim of this manuscript is to investigate transversally Ear Nose Throat (ENT) symptoms COVID-19 infection correlated and to study the neurotropism and neuroinvasiveness of the virus in the head-neck district through the investigation of the sense of smell, taste, tearing, salivation and hearing. […] Cough, fever, headache and asthenia were the most prevalent symptoms. […] In our population there was an alteration of the sense of taste, of the sense of smell, dry eyes and of the oral cavity and an auditory discomfort, symptoms probably linked to the neurotropism of the virus. […] Furthermore, anosmia, dysgeusia and xerostomia are early symptoms of COVID-19, which can be exploited for an early quarantine and a limitation of viral contagion. | 2020-06-25 |
| 32574897 | However, the effect of the COVID-19 pandemic on research endeavors and clinical trials is unclear. […] This study investigates the impact of the COVID-19 pandemic on basic science and clinical research within the rhinology community. […] Questions evaluated the impact of the COVID-19 pandemic on administrative research support and staffing, basic science research, clinical trials and resident research involvement. […] Clinical trial enrollment was most commonly limited to COVID derived studies (51%). | 2020-06-25 |
| 32574956 | The novel coronavirus pneumonia COVID-19 caused by SARS-CoV-2 infection could lead to a serious of clinical symptoms and severe illness, including acute respiratory distress syndrome (ARDS) and fatal organ failure. | 2020-06-26 |
| 32575073 | This study aims to characterize the clinical features of older and younger SARS-CoV-2 infected patients. […] In both groups, fever and cough were common symptoms. […] We retrieved clinical symptoms, laboratory findings, comorbidities, and hospitalization information of SARS-CoV-2 cases in Changsha. | 2020-06-23 |
| 32575076 | To develop treatments that can stop or lessen the symptoms and severity of SARS-CoV-2 infection, it is critical to understand how the virus behaves inside human cells, and so far studies in this area remain scarce. | 2020-06-23 |
| 32575078 | Second, compared with non-severe patients, severe patients had more serious symptoms such as fever and dyspnea. […] Our study may be helpful for clinical decision-making and optimizing resource allocation. | 2020-06-23 |
| 32575114 | This study aims to describe the clinical characteristics and perinatal outcomes of COVID-19 in pregnancy. […] Eligible studies reported clinical characteristics, radiological findings and/or laboratory testing of pregnant women during infection. […] Most common symptoms were fever (62.9%) and cough (36.8%). […] The clinical picture in pregnant women with COVID-19 did not differ from the non-pregnant population, however, the rate of preterm birth and cesarean delivery are considerably higher than international averages. | 2020-06-23 |
| 32575124 | We examined clinical and laboratory parameters including oxygen and vasopressor requirements, cytokine profiles, and C-reactive protein (CRP) levels pre- and post-tocilizumab treatment. […] Proof of efficacy awaits randomized, placebo-controlled clinical trials. | 2020-06-23 |
| 32575140 | Pregnant patients with severe acute respiratory syndrome coronavirus 2, the virus responsible for the clinical condition newly described in 2019 as coronavirus disease 2019 (COVID-19) and illness severity to warrant intensive care have a complex disease process that must involve multiple disciplines. […] Guidelines from various clinical societies, along with direction from local health authorities, must be considered when approaching the care of an obstetric patient with known or suspected COVID-19. […] With a rapidly changing landscape, a simplified and cohesive perspective using guidance from different clinical society recommendations regarding the critically-ill obstetric patient with COVID-19 is needed. […] In this article, we synthesize various high-level guidelines of clinical relevance in the management of pregnant patients with severe disease or critical illness due to COVID-19. | 2020-06-23 |
| 32575350 | We underscore the potential benefits of conducting a randomized open-label unblinded clinical trial to evaluate the role of ursodeoxycholic acid (UDCA) in the treatment of COVID-19. […] UDCA is a logical and attainable replacement for bear bile that is available in pill form and merits clinical trial consideration. | 2020-06-24 |
| 32575380 | In December 2019, a novel coronavirus, SARS-CoV-2, appeared, causing a wide range of symptoms, mainly respiratory infection. | 2020-06-24 |
| 32575505 |
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2020-06-26 |
| 32575728 | In this study, we describe an alternative RT-PCR approach for the detection of SARS-CoV-2 RNA that can be used for the probe-based detection of clinical isolates in diagnostics as well as in research labs using a low-cost SYBR green method. | 2020-06-24 |
| 32575763 | A 54-item, valid, and reliable questionnaire, including items on demographic characteristics and past medical history, stress levels, awareness about signs and symptoms of COVID-19, knowledge about at-risk groups and prevention methods, knowledge about transmission methods, trust in sources of information, and availability of facemasks and sanitizers, was deployed via social and mass media networks. | 2020-06-26 |
| 32575825 | This study aims to underline the clinical characteristics of patients who died after testing positive for SARS-CoV-2 infection in one region of Italian and to evaluate the influence of underlying health conditions on the fatal outcome. | 2020-06-26 |
| 32576016 | The application of factor analysis in the study of the clinical symptoms of coronavirus disease 2019 (COVID-19) was investigated, to provide a reference for basic research on COVID-19 and its prevention and control. […] Factor analysis was used to investigate the factors related to symptoms of COVID-19. […] Based on the combination of factors, the clinical types of the factors were defined according to our professional knowledge. […] Factor loadings were calculated, and pairwise correlation analysis of symptoms was performed. […] Factor analysis showed that the clinical symptoms of COVID-19 cases could be divided into respiratory-digestive, neurological, cough-wheezing, upper respiratory, and digestive symptoms. […] Pairwise correlation analysis showed that there were a total of eight pairs of symptoms: fever-palpitation, coughexpectoration, expectoration-wheezing, dry mouth-bitter taste in the mouth, poor appetite-fatigue, fatiguedizziness, diarrhea-palpitation, and dizziness-headache. […] The symptoms and syndromes of COVID-19 are complex. […] Respiratory symptoms dominate, and digestive symptoms are also present. […] Factor analysis is suitable for studying the characteristics of the clinical symptoms of COVID-19, providing a new idea for the comprehensive analysis of clinical symptoms. | 2020-06-24 |
| 32576055 | Our review yielded in 10 categories (i) the risk of diagnostic procedures in suspected mothers on fetus/infant health, (ii) the risk of intrauterine or postpartum transmission to the fetus/infant, (iii) appropriate method and delivery time in women with confirmed COVID-19, (iv) umbilical cord clamping and skin to skin contact, (v) clinical manifestations of infected infants, (vi) confirmation of infection in a suspected neonate/infant, (vii) instructions for infant’s care and how to feed her/him, (viii) bathing the baby, (ix) the criteria of discharging baby from the hospital, (x) the impact of isolation on the maternal mental health.Results: Our findings showed that the possibility of intrauterine or perinatal transmission of COVID-19 is still questionable and ambiguous. […] Since the motivation and stable situation of mothers allow breastfeeding during the isolation, infected mothers should be taught about breast expression skills, common breast problems, the symptoms of their baby’s infection, and the principles of personal hygiene to protect the infant against COVID-19 infection. | 2020-06-24 |
| 32576139 | Although 10-20% of patients with COVID-19 have severe symptoms, little is known about the risk factors related to the aggravation of COVID-19 symptoms from asymptomatic or mild to severe disease states. […] We evaluated the differences in demographic and clinical data between the cured (discharged to home) and transferred (aggravated to severe-stage COVID-19) groups. […] Even if patients are asymptomatic or have mild symptoms, clinicians should closely observe patients with COVID-19 presenting with chills, body temperature > 37.5 °C, findings of pneumonia in chest X-ray, or diabetes. | 2020-06-26 |
| 32576224 | The CT and clinical data were collected between January 23rd, 2020 and February 10th, 2020. | 2020-06-26 |
| 32576232 | Some features of a computed tomography scan of her chest and her clinical history with known dysphagia had led at first to a different diagnosis with a consequent exposure of health professionals to infectious risk in two distinct hospitals. […] In this case report, we describe the clinical/imaging features of coronavirus disease 2019 pneumonia and the diagnostic process that led to a correct diagnosis in a nonagenarian with multiple comorbidities. | 2020-06-26 |
| 32576291 | This type of research, previously relegated from many mainstream journals, as a low level source of evidence, has permitted the rapid reporting, publication and dissemination of much needed clinical data which can be used as a foundation to inform further research and investigations about a new global infection. | 2020-06-26 |
| 32576317 | 50.3% of respondents rated psychological distress as moderate-severe; 15.7% reported moderate-severe depressive symptoms; 22.6% reported moderate-severe anxiety symptoms; and 19.8% reported moderate-severe stress levels. | 2020-06-24 |
| 32576328 | Large-scale datasets were extracted from clinical practices. […] Ten risk factors from 44 high-dimensional clinical datasets were significantly correlated to rehabilitation duration (P < 0.05). […] According to this classification, risk management was based on a treatment flowchart for tailored clinical decisions-making. […] The proposed model is a useful tool for the individualized risk management of mild-moderate COVID-19 cases for the first time, and it may readily facilitate dynamic clinical decision-making for different risk populations. | 2020-06-24 |
| 32576343 | To investigate traditional Chinese medicine (TCM) common syndrome characteristic of coronavirus disease 2019 (COVID-19), thus providing evidence for clinical differentiation. […] Latent structure model was established based on 53 symptoms with frequency over 10, and 14 latent variables and 7 syndromes were concluded by comprehensive clustering, including syndrome of pathogenic heat invading lung, internal block and outward desertion, syndrome of dampness heat accumulating lung, syndrome of Qi and Yin deficiency, syndrome of epidemic virus closing lung, syndrome of cold dampness closing lung and syndrome of Qi deficiency of lung and spleen. […] Factor analysis was conducted for 53 symptoms, which were reported more than 10 times, and 14 common factors were obtained. […] Symptoms with load coefficient over 0.3 were clustered and 6 syndromes were obtained, including syndrome of epidemic virus closing lung, syndrome of pathogenic heat invading lung, syndrome of Qi and Yin deficiency, internal block and outward desertion, syndrome of cold dampness closing lung, and syndrome of dampness heat accumulating lung. […] Eighty-seven symptoms whose cumulative frequency was 2 838 were referred, including greasy fur (5.25%), fever (4.83%), red tongue (4.37%), rapid pulse (3.74%) and fatigue (3.46%). […] According to the results above, the common syndromes and their symptoms of COVID-19 were: (1) syndrome of pathogenic heat invading lung: fever, cough, throat-drying, headache, all of the body distressed and constipation, etc.; (2) syndrome of cold dampness closing lung: aversion to cold, all of the body distressed, nausea and vomiting, abdominal distention and loose stool, etc.; (3) syndrome of dampness heat accumulating lung: cough, sticky phlegm, anorexia, thirst without desire to drink and constipation, etc.; (4) syndrome of epidemic virus closing lung: fever, cough, yellow phlegm, wheezing, suffocation and purple lips, etc.; (5) internal block and outward desertion: coma, feel fidgety, suffocation, sweating and feel cold and purple lips, etc.; (6) syndrome of Qi and Yin deficiency: dry cough, sweating, fatigue, thirsty, feverish feeling in palms and soles and loose stool, etc.; (7) syndrome of Qi deficiency of lung and spleen: cough, wheezing, sweating, fatigue, nausea and vomiting, and loose stool, et al. […] This study could provide reference for clinical differentiation. | 2020-06-24 |
| 32576344 | Using the clinical and epidemiological database of Yangtze River Shipping General Hospital in Wuhan, the clinical and epidemiological data of 105 patients with severe and critical COVID-19 from January to March in 2020 were collected. | 2020-06-24 |
| 32576345 | To investigate the clinical characteristics and CT imaging features of patients with different clinical types of coronavirus disease 2019 (COVID-19), so as to provide a reference for the treatment and evaluation of COVID-19. […] The clinical data of 278 patients with COVID-19 admitted to Guangzhou Eighth People’s Hospital from January 20th to February 10th in 2020 were collected. […] The differences of clinical symptoms and signs, laboratory examination indexes and CT image features of lung in different clinical types were analyzed and compared, and the relationship between clinical and imaging features and clinical types of diseases were analyzed. | 2020-06-24 |
| 32576346 | To investigate the clinical significance of neutrophil-to-lymphocyte ratio (NLR) in classification of patients with coronavirus disease 2019 (COVID-19). […] The most common clinical manifestations of patients were fever (70.8%), cough (36.1%), chest tightness and breathlessness (37.5%), diarrhea (15.3%), fatigue (15.3%), vomiting and nausea (11.1%), occasionally accompanied by acute dyspnea (2.8%), and only one patient had no clinical symptom (1.4%). | 2020-06-24 |
| 32576347 | The clinical data of 72 patients with COVID-19 admitted to intensive unit of Tongji Guanggu Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology in Wuhan, Hubei Province from February 10th to 29th in 2020 were collected, including their general information, routine blood test, coagulation function, inflammatory parameters, cytokines, and organ function related laboratory parameters at admission. | 2020-06-24 |
| 32576358 | However, CRRT in COVID-19 is extraordinarily different from regular one due to different pathophysiology and infectious clinical scenarios. […] Accordingly, the paper aims to elaborate the similarities and differences between CRRT in COVID-19 and routine treatment in terms of safety and accessibility, indications and timing, clinical operation, anticoagulation, fluid management, prevention and control of infectious diseases, etc. | 2020-06-24 |
| 32576359 | From the reported cases in the literatures, the level of D-dimer in patients with coronavirus disease 2019 (COVID-19) is positively correlated with the severity of illness, which needs the attention of clinical workers. […] This article reviews the mechanism, clinical significance, understanding of TCM and common methods of promoting blood circulation and removing blood stasis caused by 2019-nCoV, in order to provide ideas for the prevention and treatment of impaired blood coagulation in patients with COVID-19. | 2020-06-24 |
| 32576424 | Among participants age 66 and above and those with chronic illness, a proportion reported experiencing one, two or all three of these symptoms. | 2020-06-26 |
| 32576457 | Coronavirus Disease-19 (COVID-19) has been in a global pandemic currently and relating symptoms were reported variously around the world. | 2020-06-26 |
| 32576508 | As for many respiratory viruses-caused diseases, diagnosis of COVID-19 relies on two main compartments: clinical and paraclinical diagnostic criteria. […] The practical intent of our work is to provide clinicians with a realistic summarized review of the essential elements in the applied paraclinical diagnosis of COVID-19. | 2020-06-26 |
| 32576608 | The role of minimally invasive surgery, patient perspectives, medico-legal aspects, and clinical trials during the pandemic are also discussed. | 2020-06-24 |
| 32576730 | We had the opportunity to examine the clinical and histopathological features of several patients who were divided into 3 groups. […] The presence of urticarial lesions, chilblains, targetoid lesions (erythema multiforme-like lesions), exanthema, maculohemorrhagic rash, or chickenpox-like lesions associated with the histopathological features mentioned previously should cause clinical dermatologists to suspect the possibility of COVID-19 infection, especially in patients with fever and cough. | 2020-06-24 |
| 32576928 | Here we report a new approach, called DREAM-in-CDM (Drug Repurposing Effort Applying Integrated Modeling-in vitro/vivo-Clinical Data Mining), to identify an FDA-approved drug suitable for use as an effective analgesic targeting mPGES-1. […] The DREAM-in-CDM approach consists of three steps: computational screening of FDA-approved drugs; in vitro and/or in vivo assays; and clinical data mining. | 2020-06-26 |
| 32576980 | Both administration and inhibition of GM-CSF are currently being therapeutically tested in COVID-19 clinical trials. | 2020-06-26 |
| 32577056 | We used method of analysis of the published papers with described studies about COVID-19 connected with pharmacological issues and aspects which are included in global fighting against COVID-19 infection, and how using DMF (Nrf2 activator) in clinical trial for nCOVID-19 produce positive effects in patients for reduce lung alveolar cells damage. we are found that Nrf2 activators an important medication that’s have a role in reduce viral pathogenesis via inhibit virus entry through induce SPLI gene expression as well as inhibit TRMPSS2, upregulation of ACE2 that’s make a competition with the virus on binding site, induce gene expression of anti-viral mediators such as RIG-1 and INFs, induce anti-oxidant enzymes, also they have a role in inhibit NF-κB pathway, inhibit both apoptosis proteins and gene expression of TLRs. […] We are concluded that use DMF (Nrf2 activator) in clinical trial for nCOVID-19 positive patients to reduce lung alveolar cells damage. | 2020-06-25 |
| 32577087 | Currently, there are limited epidemiological and clinical data on COVID-19 patients from low and middle-income countries. […] Demographic data, travel history, clinical features, and outcomes were summarized and compared between COVID-19 confirmed and non-confirmed cases. […] Among individuals with suspected COVID-19, confirmed cases were more likely to be older, Filipino, not report international travel history and have at least one underlying disease, particularly diabetes, report difficulty in breathing, and a longer duration of symptoms. […] The median duration from symptoms onset to death was 11.5 (range: 8-18) days. […] This study highlights the difficulty in diagnosing COVID-19 on clinical grounds and the importance of diagnostic capacity in all settings. […] Clinical characteristics of confirmed COVID-19 cases and a hospital case fatality rate of 21% are comparable with other settings. | 2020-06-25 |
| 32577236 | Currently, there are no proven pharmacologic interventions to reduce the clinical impact and prevent complications of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, the cause of the ongoing Coronavirus Disease of 2019 (COVID-19) pandemic. | 2020-06-25 |
| 32577324 | Currently, various ongoing clinical trials are in progress that are investigating either pharmacologic therapies or vaccines against this virus. | 2020-06-25 |
| 32577325 | However, we found some differences among these studies regarding the severity of symptoms in children affected by COVID-19. […] While a few studies stated that the virus has presented with milder symptoms in the pediatric population, some studies have presented data of children who have suffered life-threatening complications due to COVID-19. | 2020-06-25 |
| 32577331 | We present a case of a 39-year-old male who presented with chest pain without fever or respiratory symptoms. | 2020-06-25 |
| 32577426 | The clinical manifestations and factors associated with the severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections outside of Wuhan are not clearly understood. […] Fever (70.5%) and dry cough (56.0%) were the most common symptoms. | 2020-06-25 |
| 32577525 | The data support further clinical development of ChAdOx1 MERS. | 2020-06-25 |
| 32577830 | Well-designed clinical and preclinical research must be conducted to support these hypotheses. | 2020-06-26 |
| 32577901 | This study aims at estimating the prevalence of OCMT in CT scans of COVID-19 patients and investigating its clinical correlates. | 2020-06-26 |
| 32577902 | The distribution of olfactory symptoms in the case group differed at the level of statistical significance from the control group (p < 0.001). | 2020-06-26 |
| 32577905 | To give an overview of the current knowledge about COVID-19 pandemic and its impact on otolaryngology clinical practice. […] Knowledge and evidence about the impact of COVID-19 infection on otolaryngology clinical practice are accumulating rapidly. | 2020-06-26 |
| 32577997 | Apart from the evident physical symptoms in infected cases, it has caused serious damage to public mental health. […] Four hundred and three participants were asked to complete a questionnaire with questions around symptoms of depression, anxiety, stress, and family affluence. | 2020-06-26 |
| 32578156 | A literature search was conducted in PubMed and Embase to identify peer-reviewed papers reporting clinical outcomes. […] Two clinicians constructed a value tree and ranked key benefits and risks in order of considered clinical importance. […] Time to clinical improvement was not significantly different for lopinavir-ritonavir in comparison to standard of care (hazard ratio 1.31, 95% confidence interval 0.95-1.80). | 2020-06-26 |
| 32578218 | The COVID-19 pandemic has disrupted clinical nursing and midwifery education. […] These suggestions notwithstanding, we call upon national and international nursing and midwifery bodies to study how to further the clinical education of nurses and midwives during pandemics and other times of crisis. | 2020-06-24 |
| 32578289 | In this paper, we report the basic characteristics, management, clinical course, and outcomes of these patients. | 2020-06-24 |
| 32578324 | Data describing the clinical progression of coronavirus disease 2019 (COVID-19) in transplant recipients are limited. […] We developed and implemented a systematic monitoring algorithm for kidney transplant recipients at our transplant center who reported mild symptoms suggestive of COVID-19. […] The majority of mildly symptomatic patients (34/44) had clinical progression of disease and were referred to the emergency department where they all tested PCR positive and required hospitalization. […] During surge outbreaks, kidney transplant patients with even mild symptoms have a high likelihood of COVID-19 disease and most will worsen requiring hospitalization for supportive measures. | 2020-06-24 |
| 32578683 | We selected studies based upon epidemiological and clinical descriptions of the patients and mortality from the disease to determine the pooled prevalence of comorbidities in all patients and in mortality cases due to COVID-19. | 2020-06-24 |
| 32578687 | In patients with suspected clinical symptoms and typical imaging findings, in which there is still no laboratory test result, or polymerase chain reaction is not available, the role of this test is still discussed. | 2020-06-24 |
| 32578785 | Thus, we aim to show current information about COVID-19, describing symptoms and the respiratory management for critical patients and preventive care. | 2020-06-24 |
| 32578790 | In this article, we reviewed extensively all recent medical literature to point out the main clinical attitudes to support these pediatric patients during their period in respiratory support. | 2020-06-24 |
| 32578792 | This paper aggregates and consolidates some epidemiological parameters and clinical knowledge about the novel coronavirus and brings what is new in the search for pandemic control. | 2020-06-24 |
| 32578794 | The SARS-CoV-2 virus, of the Coronaviridae family, has the capacity for cellular invasion through the angiotensin-converting enzyme 2 does not have a lower respiratory epithelium and in the cells of the small intestine mucosa. a presentation can be divided into mild (fever, fatigue, cough, myalgia, and sputum) and severe (cyanosis, dyspnoea, tachypnea, chest pain, hypoxemia and need for clinical measurement) and has an estimated estimate of 2%. allows the detection of viral load in CRP-TR of patients with high clinical suspicion. based on supportive measures and infection control. | 2020-06-24 |
| 32578805 | The results reveal a critical situation in the system for meeting this potential demand, with numerous health micro-regions and macro-regions operating beyond their capacity, compromising the care for patients, especially those with more severe symptoms. | 2020-06-24 |
| 32578820 | Human infection with COVID-19 does not yet have the clinical spectrum fully described, and the pattern of lethality, mortality, infectivity and transmissibility is not known with precision. | 2020-06-24 |
| 32578825 | On the basis of the opinions of front-line experts and a review of the relevant literature on several topics, we proposed clinical practice recommendations on the following aspects for physiotherapists facing challenges in treating patients and containing virus spread: 1. personal protective equipment, 2. conventional chest physiotherapy, 3. exercise and early mobilization, 4. oxygen therapy, 5. nebulizer treatment, 6. non-invasive ventilation and high-flow nasal oxygen, 7. endotracheal intubation, 8. protective mechanical ventilation, 9. management of mechanical ventilation in severe and refractory cases of hypoxemia, 10. prone positioning, 11. cuff pressure, 12. tube and nasotracheal suction, 13. humidifier use for ventilated patients, 14. methods of weaning ventilated patients and extubation, and 15. equipment and hand hygiene. […] These recommendations can serve as clinical practice guidelines for physiotherapists. | 2020-06-24 |
| 32578826 | Although the virus is not restricted to the lung parenchyma, the use of chest imaging in COVID-19 can be especially useful for patients with moderate to severe symptoms or comorbidities. | 2020-06-24 |
| 32578915 | No study reported clinical respiratory illness as a result of virus on the masks. […] Although limited, current evidence suggests that viral carriage on the outer surface of surgical masks worn by HCW treating patients with clinical respiratory illness is low and there was not strong evidence to support the assumption that mask use may increase the risk of viral transmission. | 2020-06-24 |
| 32578933 | In this article, we will describe three lung ultrasound algorithms for the emergency diagnosis of patients presenting with respiratory symptoms during a COVID-19 pandemic: (i) LUSC19: lung ultrasound to assess the severity of COVID-19; (ii) LUSAC: lung ultrasound to exclude alternative causes of respiratory distress; and (iii) LUSI: lung ultrasound following intubation. | 2020-06-25 |
| 32579043 | Since early April 2020, there has been intense debate over proposed clinical use of ionizing radiation to treat life-threatening pneumonia in Coronavirus Disease 2019 (COVID-19) patients. […] The radiation dose proposed for clinical trials are a single dose (0.1-1 Gy) or two doses (a few mGy followed by 0.1-0.25 Gy involving a putative adaptive response, or 1-1.5 Gy in two fractions 2-3 days apart). […] Therefore, we conclude that the available scientific evidence does not justify clinical trials of LDRT for COVID-19 pneumonia, with unknown benefit and known mortality risks from radiogenic cancer and circulatory disease. […] Despite the significant uncertainties in these proposals, some clinical trials are ongoing and planned. | 2020-06-24 |
| 32579061 | Importantly, the identified FDA-approved anti-hepatitis-C virus (HCV) drugs paritaprevir and simeprevir could be ready for clinical trials to treat infected patients and help curb COVID-19. | 2020-06-24 |
| 32579067 | Technical advances in mAb identification, combined with the flexibility and clinical experience of mAbs in general, make them ideal candidates for rapid deployment. | 2020-06-24 |
| 32579176 | The discussion is structured around three domains: clinical practice, education and training, and professional values. | 2020-06-24 |
| 32579195 | To evaluate the effect of treatment with colchicine on cardiac and inflammatory biomarkers and clinical outcomes in patients hospitalized with coronavirus disease 2019 (COVID-19). […] In this prospective, open-label, randomized clinical trial (the Greek Study in the Effects of Colchicine in COVID-19 Complications Prevention), 105 patients hospitalized with COVID-19 were randomized in a 1:1 allocation from April 3 to April 27, 2020, to either standard medical treatment or colchicine with standard medical treatment. […] Primary end points were (1) maximum high-sensitivity cardiac troponin level; (2) time for C-reactive protein to reach more than 3 times the upper reference limit; and (3) time to deterioration by 2 points on a 7-grade clinical status scale, ranging from able to resume normal activities to death. […] The clinical primary end point rate was 14.0% in the control group (7 of 50 patients) and 1.8% in the colchicine group (1 of 55 patients) (odds ratio, 0.11; 95% CI, 0.01-0.96; P = .02). […] In this randomized clinical trial, participants who received colchicine had statistically significantly improved time to clinical deterioration. | 2020-06-27 |
| 32579235 | Additionally, obesity has been reported to be a risk factor for the development of acute respiratory distress syndrome (ARDS), which is a serious clinical manifestation of both COVID-19 and H1N1 infections. | 2020-06-24 |
| 32579256 | To evaluate the presence of viral RNA of SARS-CoV-2 in conjunctival swab specimen of COVID-19 patients with and without conjunctivitis to establish the diagnostic value of reverse transcription-polymerase chain reaction (RT-PCR) in each case and to describe its clinical characteristics. […] The mean days since onset of COVID-19 symptoms until conjunctivitis manifestation was 8 (range 1-24 days). | 2020-06-24 |
| 32579268 | Further studies are warranted to determine whether quantitation of these T-cell subsets may provide prognostic information on the clinical course of COVID-19. | 2020-06-24 |
| 32579293 | A retrospective study was conducted to summarize the clinical information of childhood infections during the SARS-CoV-2 epidemic. […] Clinical information was collected and compared with children and adults infected by SARS-CoV-2 in Wuhan. 52 children were enrolled, including 28 boys. […] The overall clinical manifestations were mild, and the prognosis was good. | 2020-06-24 |
| 32579306 | In addition to the involvement of the respiratory system, the infection may result in other symptoms and signs as well. […] Based on reports to date, neurological signs or symptoms appear in 30-50% of hospitalized COVID-19 patients, with higher incidence in those with more severe disease. | 2020-06-26 |
| 32579379 | In health care settings, N95 and surgical masks were probably associated with similar risks for influenza-like illness and laboratory-confirmed viral infection; clinical respiratory illness had inconsistency. […] Bothersome symptoms were common. | 2020-06-25 |
| 32579455 | Sam Foster, Chief Nurse, Oxford University Hospitals, considers how clinical supervision can be used to support staff during the COVID-19 pandemic to help prevent burnout. | 2020-06-24 |
| 32579466 | John Tingle, Lecturer in Law, Birmingham Law School, University of Birmingham, discusses how the Courts may view clinical negligence claims brought by families who have lost loved ones during the pandemic. | 2020-06-24 |
| 32579597 | ARBs and/or ACEi treatments, and hypertension, diabetes, cancer, COPD, renal and major cardiovascular diseases (CVD) were extracted from clinical charts and electronic health records, up to two years before infection. […] The sample consisted of 1603 subjects (mean age 58.0y; 47.3% males): 454 (28.3%) had severe symptoms, 192 (12.0%) very severe or lethal disease (154 deaths; mean age 79.3 years; 70.8% hypertensive, 42.2% with CVD). | 2020-06-24 |
| 32579707 | The clinical presentation of COVID-19 varies from mild fever, cough, dyspnea in the early stages of disease to severe complications such as acute respiratory distress syndrome, systemic hyperinflammation and sepsis. […] This review offers key clinical pharmacology considerations involved in the development of small molecules for the treatment of COVID-19. | 2020-06-24 |
| 32579880 | Recent clinical studies show a strong association with COVID-19 and diabetes. | 2020-06-27 |
| 32579906 | We described and compared the epidemiological and clinical characteristics of the cases recorded in different phases of the epidemic and reviewed the effectiveness of the public health measures implemented using the changes in the daily number of confirmed cases and the interval from symptom onset to hospital admission. | 2020-06-26 |
| 32579983 | A multivariable predictive model including FebriDx, age, sex, and clinical characteristics was developed and underwent internal validation. […] In the multivariate model age, sex and other clinical features did not contribute significantly to the effect of the FebriDx result in distinguishing patients with and without COVID-19. | 2020-06-26 |
| 32580213 | In this short communication, we describe our first clinical experiences with 55 COVID-19 patients in Central Switzerland, who were either imaged with a standard chest x-ray, chest CT, or both. […] We provide an illustrative and schematic description of typical COVID-19 imaging features and suggest that imaging plays an important role in the clinical work-up of suspected or confirmed COVID-19 patients. | 2020-06-24 |
| 32580215 | Clinical information about patients undergoing lung resection while infected with this virus and pathological information about early COVID-19 pneumonia are still scarce. […] From this day, the COVID-19 test, which was performed after the appearance of symptoms such as fever and shortness of breath, lymphopenia and diffuse ground glass opacity in the left lung on computed tomography, was reported to be positive. […] We believe that the clinical course and pathology findings obtained after right pneumonectomy in a patient with pre-symptomatic COVID-19 pneumonia will guide the diagnosis and treatment of patients infected with SARS-CoV-2. | 2020-06-24 |
| 32580257 | While common symptoms are flu-like, this population has been observed to decompensate at an alarmingly rapid rate to severe hypoxia. […] Compassionate use of pharmacologic therapies such as remdesivir has shown promise, and further clinical trials of anticytokine agents are underway. | 2020-06-24 |
| 32580258 | Based on the most recently published evidence, this article will review and discuss comprehensive information on its clinical manifestations, laboratory tests, potential therapeutics, and prevention guidelines. | 2020-06-24 |
| 32580344 | The emerging epidemiological data about COVID-19 patients suggest an association between cardiovascular diseases (CVD) and SARS-CoV-2 infection, in term of clinical features at hospital admission and prognosis for disease severity. […] The aim of our review is to describe the cardiological features of COVID-19 patients at admission, the acute cardiac presentation, the clinical outcome for patients with underlying CVD and the pharmacological implications for disease management. | 2020-06-25 |
| 32580440 | Moreover, PM induces inflammation in lung cells and exposure to PM could increase the susceptibility and severity of the Covid-19 patient symptoms. | 2020-06-25 |
| 32580529 | As our aim is to evaluate the efficacy of Covid-19 rapid tests and of serological assays in real-life settings, we designed a research protocol aimed to establish how to use correctly these diagnostics, taking into account the different possible clinical and epidemiological scenarios. | 2020-06-25 |
| 32580531 | We conducted in-depth interviews with patients and guardians; interviews with primary physicians; review of medical records and drug utilization review (DUR) reports; and base station-based location tracking. […] Four cases (4.0%) of early detection led to confirmed diagnosis during the incubation period and presentation of symptoms after diagnosis. […] In addition, the remaining four patients (4.0%), having no subjective symptoms nor specific findings on chest radiography and Computed Tomography, remained asymptomatic until the isolation order was lifted. […] The possibility of transmission during the asymptomatic period has been confirmed; therefore, it is necessary to review the measures for expanding contact tracing that is currently being applied starting one day prior to the onset of symptoms. | 2020-06-25 |
| 32580752 | Traditional Chinese medicine (TCM) has been widely applied in the treatment of a variety of infection diseases in China, hoping to produce clinical effects and reduce the use of antibiotics and glucocorticoid. […] The clinical indicators of patients will be assessed at baseline and at 3, 5, 7, and 14 days after treatment initiation. […] The primary outcome is 14-day clinical outcome. […] Chinese Clinical Trial Registry, ChiCTR2000029777. | 2020-06-27 |
| 32580799 | Of the 1120 respondents (M: F 1.7:1, age 35 years ±14.1) most expressed a high level of perceived knowledge and confidence of managing COVID-19, such as awareness of the symptoms of the illness (95.1%), actions needed (94.4%), hospital to report to (88.9%), and emergency contact number (89.1%). | 2020-06-25 |
| 32580895 | JAK inhibition, therefore, presents an attractive therapeutic strategy for CRS, which is a common cause of adverse clinical outcomes in COVID-19. | 2020-06-27 |
| 32580925 | The classic symptoms of the disease have been well defined by the World Health Organization; however, olfactory/gustatory disorders have been reported in some studies, but there are still several missing points in the understanding and in the consensus about the clinical management of these cases. […] To identify evidence in the scientific literature about olfactory/gustatory disorders, their clinical presentation, prevalence and possible specific treatments associated with COVID-19. […] A systematic review of articles published up to April 25, 2020 was performed in Medline, Cochrane Clinical Trials, ScienceDirect, Lilacs, Scopus and Google Schoolar, OpenGrey.eu, DissOnline, The New York Academy of Medicine and Reasearch Gate. […] (1) Studies on patients with COVID-19; (2) Records of COVID-19 signs/symptoms, and olfactory/gustatory functions. […] There were olfactory/gustatory disorders even without nasal obstruction/rhinorrhea and beginning even before the signs/symptoms of COVID-19; the recovery of smell/taste, when it occurs, usually happened in the first two weeks after COVID-19 resolution. […] Olfactory/gustatory disorders may occur at varying intensities and prior to the general symptoms of COVID-19 and should be considered as part of the clinical features of COVID-19, even in mild cases. | 2020-06-27 |
| 32580948 | Clinical and analytical performance of the test were validated in an observational study using residual samples (>1500) with positive or negative COVID-19 diagnosis. | 2020-06-25 |
| 32580969 | In this review, we address epidemiological, diagnostic, clinical, and therapeutic aspects, including perspectives of vaccines and preventive measures that have already been globally recommended to counter this pandemic virus. | 2020-06-25 |
| 32581016 | The objective of the present study was to clarify further the clinical characteristics and blood parameters in COVID-19 patients. […] Epidemiological, clinical, laboratory, and treatment data were collected and analyzed. […] On admission, the most common symptoms were fever (75%) and cough (76.6%). […] Results of blood tests have potential clinical value in COVID-19 patients. | 2020-06-25 |
| 32581017 | This suggests that a targeted therapy could address the biology of COVID-19 pneumonia, enhance the host immune response and prevent its progression to a life-threatening, ventilator-dependent clinical situation. | 2020-06-25 |
| 32581069 | Within this framework, it is crucial to ensure no disruption to essential oncological services and guarantee the optimal care.This is a structured proposal for the management of lung cancer, comprising three levels of priorities, namely: tier 1 (high priority), tier 2 (medium priority) and tier 3 (low priority)-defined according to the criteria of the Cancer Care Ontario, Huntsman Cancer Institute and Magnitude of Clinical Benefit Scale.The manuscript emphasises the impact of the COVID-19 pandemic on lung cancer care and reconsiders all steps from diagnosis, staging and treatment.These recommendations should, therefore, serve as guidance for prioritising the different aspects of cancer care to mitigate the possible negative impact of the COVID-19 pandemic on the management of our patients.As the situation is rapidly evolving, practical actions are required to guarantee the best patients’ treatment while protecting and respecting their rights, safety and well-being. | 2020-06-25 |
| 32581077 | Different inflammatory genes mined here, including TNFR, IL-8, CXCR1, CXCR2, ADAM10, GPR84, MME, ANPEP, and LAP3, might be druggable targets in efforts to limit SARS-CoV-2 inflammation in severe clinical cases. | 2020-06-25 |
| 32581324 | Given the wide clinical spectrum of COVID-19, understanding the factors that can predict disease severity will be essential since this will help frontline clinical staff to stratify patients with increased confidence. | 2020-06-27 |
| 32581514 | This study aimed to evaluate the fundamental characteristics of coronavirus disease (COVID-19) clinical trials registered in China. […] COVID-19 clinical trials registered in China were analyzed from databases on ChiCTR and ClinicalTrials.gov. […] In total, 262 intervention clinical trials were retrieved on March 10, 2020. […] This study is the first snapshot of the landscape of COVID-19 clinical trials registered in China and provided the basic features of clinical trial designs for the treatment and prevention of COVID-19 to offer useful information to guide future clinical trials on COVID-19 in other countries. | 2020-06-26 |
| 32581612 | In each hospital, we chose the respiratory and ear-nose-throat outpatient departments (OPDs) and the emergency department (ED) to invite patients with symptoms of cough to join the study before they consulted a physician. | 2020-06-26 |
| 32581809 | This commentary elaborates on the pharmacological rationale of repositioning the mast cell stabilizer chromones as an adjunctive treatment for SARS-CoV-2 infection, and proposes their practical clinical testing as an early, safe, and cost-effective anti-inflammatory intervention in COVID-19 to limit the eventual secondary progression toward life-threatening respiratory complications. | 2020-06-26 |
| 32581810 | Based on the hypothesis that complement and coagulation cascades are activated by viral infection, and might trigger an acute respiratory distress syndrome (ARDS), we report clinical outcomes of 17 consecutive cases of SARS-CoV-2-related ARDS treated (N = 7) with the novel combination of ruxolitinib, a JAK1/2 inhibitor, 10 mg/twice daily for 14 days and eculizumab, an anti-C5a complement monoclonal antibody, 900 mg IV/weekly for a maximum of three weeks, or with the best available therapy (N = 10). […] Patients treated with the combination showed significant improvements in respiratory symptoms and radiographic pulmonary lesions and decrease in circulating D-dimer levels compared to the best available therapy group. | 2020-06-26 |
| 32581816 | Severely ill patients experience pathologic manifestations of acute respiratory distress syndrome (ARDS), and clinical reports demonstrate striking neutrophilia, elevated levels of multiple cytokines, and an exaggerated inflammatory response in fatal COVID-19. | 2020-06-27 |
| 32581854 | Alike other coronaviruses, SARS-CoV-2 has a neuroinvasive potential, which may be associated with early neurological symptoms. […] Beyond the infection-associated neurological symptoms, long-term neuropsychiatric consequences that could occur months after the host recovery are not to be excluded. | 2020-06-26 |
| 32582134 | This review describes the main clinical features of COVID-19 and potential role of microbiota in COVID-19. […] SARS and COVID-19 share similar clinical features, although the estimated fatality rate of COVID-19 is much lower. | 2020-06-26 |
| 32582137 | The recent outbreak in severe acute respiratory syndrome - coronavirus-2 (SARS-CoV-2) has demonstrated the complete inability of nations across the world to cope with the pressures of a global pandemic, especially one in which the only current feasible treatments are those which deal with the symptoms alone and not the viral cause. […] In this case, the use of biosurfactants in dealing with this pandemic justifies extensive study with their potential applications being in the prevention of viral spread; dealing with the symptoms that develop after the incubation period; directly targeting viral infected cells and preventing the spread of the virus throughout the host, all in addition to also acting as potential drug delivery systems and cleaning agents. | 2020-06-26 |
| 32582138 | In addition to the typical symptoms of pulmonary infection, patients with COVID-19 have been reported to have gastrointestinal symptoms and/or intestinal flora dysbiosis. […] More clinical and evidence-based medical trials may be initiated to determine the strategy. | 2020-06-26 |
| 32582200 | First, the relative absence of clinical signs of infections in children, second, the early appearance of IgG in certain patients. […] The worst scenario would be when such cross-reactive memory antibodies to related coronaviruses would not only be non-protective but even enhance infection and the clinical course. […] On the contrary, due to cross-reaction to related coronavirus strains from earlier infections, in certain patients IgG might enhance clinical progression due to ADE. | 2020-06-26 |
| 32582302 | Coronavirus disease 2019 (COVID-19) shows a wide variation in expression and severity of symptoms, from very mild or no symptoms, to flu-like symptoms, and in more severe cases, to pneumonia, acute respiratory distress syndrome, and even death. | 2020-06-26 |
| 32582307 | To determine the clinical and demographical profile of corona-virus illness among Tablighi Jamaat and Zaireen kept in quarantine / isolation center at Sukkur and Hyderabad Sindh. […] All the individuals regardless of age and gender presented either as asymptomatic, critical ill or having non-specific symptoms as fever, flu, cough; sore throat and shortness of breath were screened for COVID-19 by real time PCR after taking informed consent whereas the frequency / percentages (%) and means ±SD computed for study variables. | 2020-06-26 |
| 32582308 | Many of HCPs are anxious nowadays, having symptoms related to burn out with logical reasons behind. […] The symptoms of burn out are significant and would increase with passage of time. | 2020-06-26 |
| 32582311 | Overall, >90% people were aware about the etiology, mode of transmission and possible symptoms; however, very few of them knew about the in-depth details. | 2020-06-26 |
| 32582314 | The majority (81.9%) believed that the sign and symptoms are similar to a common flu and the main strata of population that could be affected by COVID-19 are elderly (79%). | 2020-06-26 |
| 32582317 | In this article, we highlight children’s vulnerability, provide an overview of common symptoms of distress in different age groups, and summarize the interventions and resources available to promote child mental health and wellbeing during these challenging times. | 2020-06-26 |
| 32582319 | Clinical symptoms of CoViD-19 include fever, dry cough, dyspnea, loose stool, nausea and vomiting. | 2020-06-26 |
| 32582330 | Patients usually have respiratory symptoms but gastrointestinal and hepatic dysfunction are not uncommon presentations and can lead to a delay in diagnosis and management. | 2020-06-26 |
| 32582332 | The most practical compromise for Pakistan appears to be the use of portable digital radiography equipment, and point-of- care ultrasound; with CT scan reserved for clinical situations not explained by the above two modalities, or demanding disease stratification. | 2020-06-26 |
| 32582338 | To develop an effective approach to manage and learning from health emergencies, we have launched Isfahan COvid-19 REgistry for data collection during routine clinical care as a first “critical incident registry” in Iran. […] Registries can be employed to explain the natural history of the disease, learn about a particular disease in terms of patient outcomes, the cost-effectiveness of clinical management, monitoring the quality of health-care service, and developing research hypotheses. | 2020-06-26 |
| 32582401 | In this review, we report the background of severe cases of COVID-19, basic aspects and mechanisms of action of MSCs and their exosomes, and discuss basic and clinical studies based on MSCs and exosomes for influenza-induced ARDS. […] Finally, we report the potential of MSC and exosome therapy in severe cases of COVID-19 in recently initiated or planned clinical trials of MSCs (33 trials) and exosomes (1 trial) registered in 13 countries on ClinicalTrials.gov. | 2020-06-26 |
| 32582489 | In light of the patient’s poor clinical status, age, and significant comorbidities, prognosis was conveyed about medical futility and patient’s family agreed to terminal extubation and the patient expired peacefully, exactly one week from hospital admission. | 2020-06-26 |
| 32582614 | Lacking clear information about viral load on tissue samples, all human specimens must be considered potentially infectious, as well as patients during post-mortem examinations, and clinical information on COVID-19 status is mandatory. | 2020-06-26 |
| 32582615 | Clinical characteristics and outcome data were collected and analyzed. Results: Of 869 patients, the median age was 51 years (IQR, 40-58 years), and 377 patients (377/869; 43.4%) were men. […] The incidence of the main symptoms, including fever, cough, fatigue, muscle aches, and anorexia, decreased with time. […] The initial symptoms of mild-moderate patients may become insidious, which deserves our attention. | 2020-06-26 |
| 32582617 | In this study, serological testing was applied when identifying nine asymptomatic cases of COVID-19 who showed persistent negative RT-PCR test results for SARS-CoV-2 nucleic acid and no symptoms of COVID-19. […] Two asymptomatic cases were presumed to be index patients who had cleared the virus when their close contacts developed symptoms of COVID-19. […] Three of the asymptomatic cases were local individuals who spontaneously recovered before their presumed index patients developed symptoms of COVID-19. […] This report presents the epidemiologic and clinical characteristics of asymptomatic individuals with SARS-CoV-2 infection that were undetected on RT-PCR tests in previous epidemiologic investigations probably due to the transient viral shedding duration. | 2020-06-26 |
| 32582718 | Testing is crucial to track the spread of disease during a pandemic, and to swiftly permit public health interventions including isolation, quarantine, and appropriate clinical management of afflicted individuals. | 2020-06-26 |
| 32582719 | In this review, we highlight the etiology, epidemiology, pathogenesis and pathology, clinical characteristics, diagnosis, clinical management, prognosis, infection control and prevention of COVID-19 based on recent studies. | 2020-06-26 |
| 32582740 | Objective: This study evaluated the clinical and epidemiological characteristics of patients with confirmed coronavirus disease 2019 (COVID-19). Methods: This retrospective study evaluated 29 patients with confirmed COVID-19 infection admitted to Henan Provincial People’s Hospital between January 27 and February 27, 2020, with follow-up until April 01, 2020. Results: The median age of the patients was 56 years. […] The most frequent presenting symptoms were fever, cough, and sputum production. […] Need of oxygen therapy, mechanical ventilation, intravascular immunoglobulin, and duration of antibiotic therapy were increased in those with severe disease. Conclusions: Significant differences in demographical and clinical characteristics were observed in patients with moderate and severe COVID-19. | 2020-06-26 |
| 32582741 | Emerging reports of atypical and delayed clinical presentations in these patients generate further concerns for widespread disease transmission to medical personnel and the community. | 2020-06-26 |
| 32582743 | Furthermore, we found that NLR, as a novel marker of systemic inflammatory response, can also help predict clinical severity in patients with COVID-19 (OR = 2.50, 95% CI: 2.04-3.06). Conclusions: Immune-inflammatory parameters, such as WBC, lymphocyte, PCT, CRP, and NLR, could imply the progression of COVID-19. | 2020-06-26 |
| 32582745 | It causes mild to severe respiratory illness with some flu-like symptoms. […] However, patients with hemoglobin disorders (e.g., sickle cell anemia, thalassemia) are vulnerable to this global health situation due to their clinical complications. | 2020-06-26 |
| 32582747 | Implementing proper strategies addressing the infection control and clinical supplies, understanding the mechanism associated with pathogenesis, advancing in preventive measures and effective treatment and diagnostic options are necessary to control the ongoing pandemic. | 2020-06-26 |
| 32582748 | We aimed to establish a relationship between the signs and symptoms of COVID-19 for early detection and assessment to reduce the transmission rate of SARS-Cov-2. Methods: We collected published data on the clinical features of Covid-19 retrospectively and categorized them into physical and blood biomarkers. […] Correlations between signs and symptoms with the development of Covid-19 was assessed by Pearson correlation and Spearman Correlation coefficient (rho). […] The frequency of signs and symptoms in developing Covid-19 was assessed through Chi-square test two tailed with Cramer’s V strength. […] Changes in signs and symptoms were incorporated into a chart that consisted of four tiers representing disease stages. Results: Data from 10,172 Covid-19 laboratory confirmed cases showed a correlation with Fever in 43.9% (P = 0.000) cases, cough 54.08% and dry mucus 25.68% equally significant (P = 0.000), Hyperemic pharyngeal mucus membrane 17.92% (P = 0.005), leukopenia 28.11% (P = 0.000), lymphopenia 64.35% (P = 0.000), thrombopenia 35.49% (P = 0.000), elevated Alanine aminotransferase 50.02% (P = 0.000), and Aspartate aminotransferase 34.49% (P = 0.000). […] Moderate stage scored 23-33 and severe scored 34-39 in the chart. Conclusion: The Hashmi-Asif Covid-19 Chart is significant in assessing subclinical and clinical stages of Covid-19 to reduce the transmission rate. | 2020-06-26 |
| 32582749 | Demographic, clinical, laboratory, and radiological data from COVID-19 patients on hospital admission were extracted and were compared between the two groups, defined as short- and long-term hospitalization, respectively according to the median hospitalization time. | 2020-06-26 |
| 32582936 | In a retrospective study of 39 COVID-19 patients and 32 control participants in China, we collected clinical data and examined the expression of endothelial cell adhesion molecules by enzyme-linked immunosorbent assays. | 2020-06-25 |
| 32582946 | Pharmaceutical companies have either stopped recruitment or even cancelled ongoing clinical trials in chronic diseases. | 2020-06-25 |
| 32583009 | Only, 4.8% knew about common symptoms of COVID-19 and 7.3% about warning signs that require referral to hospitals. | 2020-06-27 |
| 32583078 | Therefore, this meta-analysis first aims to explore the possible clinical mortality between diabetes and COVID-19, analyze if diabetes patients infected with SARS-CoV-2 are exposed to the worst clinical prognostic risk, and to evaluate the reliability of the evidence. […] More importantly, this meta-analysis grades the reliability of evidence for further basic and clinical research into the diabetes dysfunction in COVID-19 patients. | 2020-06-27 |
| 32583086 | This review also highlights potential targets for prevention and therapy of COVID-19-related organ damage and discusses the role of marketed drugs, such as eculizumab and imatinib, as suitable candidates for clinical trials. | 2020-06-27 |
| 32583169 | Although the majority of patients present with fever, dyspnea, cough, or myalgia, various signs and symptoms have been reported for this disease. […] Recently, neurological symptoms have been noticed in patients with COVID-19 with unknown etiology. […] In this series, six patients younger than 55 years of age with diagnosis of stroke and a confirmed diagnosis of COVID-19 were evaluated for symptoms, lab data, imaging findings, and outcomes from March 2020 to the end of April 2020 from all stroke cases in a tertiary academic hospital. […] Fever, myalgia, cough, and dyspnea were the most common clinical symptoms noted in 66.66% (4/6), 66.66% (4/6), 50% (3/6), and 50% (3/6) of the patients, respectively. | 2020-06-27 |
| 32583183 | COVID-19 patients may present mild symptoms. […] Olfactory loss could be one of those early symptoms which might help in the diagnosis of COVID-19 patients. […] Olfaction was assessed with the ethyl alcohol threshold test and symptoms with visual analogue scales. | 2020-06-27 |
| 32583289 | When conducting clinical trials under COVID-19 pandemic, protocol deviations and/or protocol violations are inevitably encountered due to possible environment change which may have an impact on the accuracy and reliability of clinical evaluation of the test treatment under investigation. […] Protocol deviations and/or violations include, but are not limited to, eligibility criteria, testing procedure, dose and dose regiment, treatment duration and clinical operation of the intended trial. […] FDA published guidance in March 2020 to assist investigators and institutional boards (IRBs) in assuring the safety of trial participants, maintaining compliance with good clinical practice, and minimizing risks to trial integrity during the COVID-19 pandemic. […] The purpose of this article is to proposal methods for statistical evaluation in terms of (i) possible shift in target patient population and (ii) assessment of reproducibility of clinical studies conduct under COVID-19 pandemic environment. […] The proposed methods can be used to determine whether the clinical results of the intended trials are acceptable from both statistical and regulatory perspectives. | 2020-06-27 |
| 32583465 | In this article, we discuss the process changes we instituted for cellular therapy clinical care, collection, processing, and cryopreservation to cope with the rapidly evolving pandemic. | 2020-06-25 |
| 32583536 | Factors that influenced anxiety also included household income, subjective symptoms, and attitudes. | 2020-06-25 |
| 32583671 | We herein presented two clinical cases of laryngectomized patients affected by COVID-19, detailing their clinical course and complications. | 2020-06-25 |
| 32583680 | Recommendations are provided according to each clinical situation: patients undergoing treatment, new cases, hospitalized patients, palliative care and surveillance. | 2020-06-27 |
| 32583765 | Containment strategies and clinical management of coronavirus disease (COVID-19) patients during the current pandemic depend on reliable diagnostic PCR assays for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). | 2020-06-25 |
| 32583808 | Though fever and respiratory symptoms are most common, many children also have gastrointestinal manifestations. | 2020-06-25 |
| 32583809 | HScore can be used as a complement to clinical decision for initiating immunosuppression. | 2020-06-25 |
| 32583852 | There was conflicting evidence regarding whether antibody titers correlated with clinical severity. | 2020-06-25 |
| 32584062 | First, it describes challenges to HSP education and training created by the COVID-19 pandemic, including the need to maintain the integrity of training; facilitate trainee progress; continue clinical service delivery; manage the safety and wellbeing of trainees, faculty, staff, and clients/patients; and adhere to national and local emergency orders. […] Second, the article summarizes guidance from training organization leadership regarding training program and clinical site responses to these challenges. | 2020-06-25 |
| 32584103 | Although the ethical and clinical imperative of providing culturally-competent health care has long been recognized, the influence of culturally-competent interventions within emergency management has not been systematically examined. | 2020-06-25 |
| 32584110 | These areas are central components to our mission at the Clinical-Disaster Research Center, housed in the Department of Psychology at the University of Mississippi and part of the university’s doctoral training program in clinical psychology. | 2020-06-25 |
| 32584161 | NEWS2 at hospital admission, demographic, comorbidity and clinical data were collected. […] No other clinical variables included in the model were significantly correlated with ICU admission.A NEWS2 threshold of 5 had higher sensitivity than a threshold of 7 (89% and 63%). | 2020-06-25 |
| 32584167 | We discuss the positives, pitfalls, and perils of the new roles and the first impressions of three newly qualified FiY1 s in medical, obstetrics and gynaecology and surgical posts, a surgical FY1 doctor and a clinical supervisor in surgery. | 2020-06-26 |
| 32584199 | Coronaviruses, seven of which are known to infect humans, can cause a spectrum of clinical presentations ranging from asymptomatic infection to severe illness and death. […] Clinical symptoms and laboratory and radiological abnormalities in children have been similar to those reported in adults but are generally less severe. […] Clinical trials for therapeutics and vaccine development should include paediatric considerations. | 2020-06-25 |
| 32584236 | In this narrative review, the Turkish Thoracic Society Early Career Taskforce members aimed to provide a summary on recent literature regarding epidemiology, clinical findings, diagnosis, treatment, prevention, and control of COVID-19. […] Fever and cough were the most common symptoms, and cardiovascular diseases and hypertension were reported to be the most common comorbidities among patients. […] Clinical manifestations range from asymptomatic and mild disease to severe acute respiratory distress syndrome. […] Several patients showed typical symptoms and radiological changes with negative RT-PCR but positive IgG and IgM antibodies. | 2020-06-26 |
| 32584326 | The objective of the study to describe the clinical features of COVID-19 patients diagnosed in a tertiary-care center in Mexico City and to assess differences according to the treatment setting (ambulatory vs. hospital) and to the need of intensive care (IC). […] At admission, patients with diabetes, high BMI, and clinical or laboratory findings consistent with a severe inflammatory state were more likely to require IC. | 2020-06-26 |
| 32584330 | The number of comorbidities may be a determining factor in the clinical course and its outcomes in SARS-CoV-2-positive patients. | 2020-06-26 |
| 32584397 | Clinical findings fit into the following patterns: acral erythema (6 patients), dactylitis (4 patients), purpuric maculopapules (7 patients), and a mixed pattern (3 patients). […] The clinical, histologic, and laboratory test results were compatible with a diagnosis of perniosis, and no evidence was found to support the implication of SARS-CoV-2 infection. | 2020-06-25 |
| 32584403 | Out of 53 pilgrims, 48 (90.5%) were tested positive for SARS-CoV-2; of them, 41 (85.4%) developed symptoms consistent with COVID-19, and 7 (14.6%) remained asymptomatic. | 2020-06-25 |
| 32584418 | The optimal treatment for patients with newly diagnosed acute myeloid leukaemia (AML) who are infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)/COVID-19 is unknown.1 We report the case of a previously fit 27-year-old male who presented with a 3-day history of fever (>39 C), swollen, erythematous elbows and no respiratory symptoms. | 2020-06-25 |
| 32584464 | We included all reference standards to define the presence or absence of SARS-CoV-2 (including reverse transcription polymerase chain reaction tests (RT-PCR) and clinical diagnostic criteria). […] Pooled results for IgG, IgM, IgA, total antibodies and IgG/IgM all showed low sensitivity during the first week since onset of symptoms (all less than 30.1%), rising in the second week and reaching their highest values in the third week. […] Assuming a prevalence of 50%, a value considered possible in healthcare workers who have suffered respiratory symptoms, we would anticipate that 43 (28 to 65) would be missed and 7 (3 to 14) would be falsely positive in 1000 people undergoing IgG/IgM testing at days 15 to 21 post-symptom onset. […] Antibody tests are likely to have a useful role for detecting previous SARS-CoV-2 infection if used 15 or more days after the onset of symptoms. […] Concerns about high risk of bias and applicability make it likely that the accuracy of tests when used in clinical care will be lower than reported in the included studies. […] Studies must report data on sensitivity disaggregated by time since onset of symptoms. | 2020-06-26 |
| 32584487 | We discuss the disproportionate burden of disease among Hispanic/Latino and black/African-American ancestry, the distinct cytokine signature across the disease spectrum (IL-1/IL-6), and the potential role and pathogenesis of SARS-CoV-2 in this new clinical entity. | 2020-06-25 |
| 32584597 | In critically unwell COVID-19 patients, increases in IL-6:AAT predicted prolonged ICU stay and mortality, while improvement in IL-6:AAT was associated with clinical resolution (P<0.0001). | 2020-06-25 |
| 32584760 | The patient had sparse pulmonary symptoms despite characteristic COVID-19 lesions on CT-thorax and developed severe acral ischaemic change, after a few days of hospitalisation. | 2020-06-25 |
| 32584766 | In this case report, a 70-year-old male was admitted to the hospital with respiratory tract symptoms and a fever, and he was isolated, suspected of COVID-19. | 2020-06-25 |
| 32584795 | To date, data to assess the prevalence and severity of COVID-19 among pregnant U.S. women and determine whether signs and symptoms differ among pregnant and nonpregnant women are limited. | 2020-06-25 |
| 32584797 | For this report, data were abstracted from the medical records of 220 hospitalized and 311 nonhospitalized patients aged ≥18 years with laboratory-confirmed COVID-19 from six acute care hospitals and associated outpatient clinics in metropolitan Atlanta, Georgia. | 2020-06-25 |
| 32584802 | Persons experiencing signs or symptoms of serious illness, such as severe chest pain, sudden or partial loss of motor function, altered mental state, signs of extreme hyperglycemia, or other life-threatening issues, should seek immediate emergency care, regardless of the pandemic. | 2020-06-25 |
| 32584868 | Electronic medical records were reviewed to obtain information on sex, age, personal antecedents, clinical features, findings on physical examination, and laboratory results for each patient. | 2020-06-25 |
| 32584894 | Only 36% of the positively tested employees did suffer from flu-like symptoms in 2020. | 2020-06-25 |
| 32584953 | More detailed epidemiological and clinical information should be measured in further studies. | 2020-06-25 |
| 32584954 | Older people are disproportionately affected by the COVID-19 pandemic, which has had a profound impact on research as well as clinical service delivery. | 2020-06-25 |
| 32584978 | Patients were also classified into groups according to their pathological and clinical status: emergency, urgent and non-deferrable (ND). […] The involvement of the telematic management heart team allowed constant updates and clinical discussions. | 2020-06-25 |
| 32585065 | In this multi-center retrospective study, we evaluated hospitalized adults with laboratory-confirmed COVID-19 and the impact of CLD on relevant clinical outcomes. […] Future studies are needed to identify interventions to improve clinical outcomes. | 2020-06-25 |
| 32585069 | Patients’ ≥18 years of age with clinical features and abnormal chest imaging with confirmed COVID-19 by RT-PCR for SARS-Cov-2 were included. […] CAPA was diagnosed based on clinical parameters, radiological findings and mycological data. | 2020-06-25 |
| 32585074 | A consistent number of case reports and clinical series have been already published describing a complex spectrum of skin manifestations associated with the SARS-CoV-2 infection. | 2020-06-25 |
| 32585136 | The clinical implications of liver derangement might be variable in different clinical scenarios. […] With growing evidence of its clinical significance, it would be clinically helpful to provide practice recommendations for various common clinical scenarios of liver derangement during the COVID-19 pandemic. […] The Asia-Pacific Working Group for Liver Derangement during the COVID-19 Pandemic was formed to systematically review the literature with special focus on the clinical management of patients who have been or who are at risk of developing liver derangement during this pandemic. […] Clinical scenarios covering the use of pharmacological treatment for COVID-19 in the case of liver derangement, and assessment and management of patients with chronic hepatitis B or hepatitis C, non-alcoholic fatty liver disease, liver cirrhosis, and liver transplantation during the pandemic are discussed. | 2020-06-27 |
| 32585284 | The use of TPE in severe COVID-19 patients has been associated with improved outcomes, however, randomized controlled clinical trials are warranted to draw final conclusive findings. | 2020-06-27 |
| 32585295 | This is supported by preclinical and clinical data from other diseases with hyperinflammatory states, where ruxolitinib has been shown to reduce cytokine levels and improve outcomes. | 2020-06-27 |
| 32585353 | We further implemented Dorfman pooling with a pool size of 8 samples in large-scale clinical tests. […] Pooling approaches for SARS-CoV-2 testing allow a drastic increase in throughput while maintaining clinical sensitivity. | 2020-06-27 |
| 32585364 | In this review, I will summarize the clinical data on the risk for infectious diseases in individuals with diabetes, highlighting the mechanisms for altered immune regulation. […] In the light of the new clinical data obtained from COVID-19 patients, mechanisms such as cytokine storm, pulmonary and endothelial dysfunction, hypercoagulation that may render individuals with diabetes more vulnerable to COVID-19 will be discussed in the end. […] Given the global burden of diabetes and pandemic nature of coronaviruses, understanding how diabetes affects COVID-19 severity is critical to design tailored treatments and clinical management of individuals affected by diabetes. | 2020-06-27 |
| 32585435 | The algorithm is based on expert opinion and clinical experience between March and April of 2020, during which the institution cared for 47 COVID-19 positive psychiatric inpatients. | 2020-06-27 |
| 32585617 | We describe our experience in seven cases of patients with multiple sclerosis who have been affected by SARS-COV-2 (with a clinical/serological diagnosis or PCR diagnosis) and who were being treated with anti-CD20+ monoclonal antibodies. […] We review the development of patients during infection as well as the resolution of their clinical picture. […] Although the severity of the clinical pictures was variable, patients’ development was good. […] It is possible that the presence of humoral immunity is not always necessary fora good clinical course of SARS-CoV-2 infection. | 2020-06-27 |
| 32585699 | Here, we provide an updated overview of the impact of tobacco/waterpipe (shisha) smoking and e-cigarette vaping on endothelial function, a biomarker for early, subclinical, atherosclerosis from human and animal studies. […] As outlined by the WHO, tobacco cigarette, waterpipe, and e-cigarette smoking/vaping may contribute to an increased burden of symptoms due to coronavirus disease 2019 (COVID-19) and to severe health consequences. | 2020-06-25 |
| 32585765 | Symptoms of pneumonia together with lymphopenia from complete blood count were developed on day 7 after onset of fever with the x-ray finding of bilateral multifocal patchy infiltration. […] Symptoms of pneumonia were improved which no oxygen treatment required from day 10 of hospitalization. | 2020-06-25 |
| 32585805 | While hundreds of vaccines/therapeutics are still in the preclinical or early stage of clinical development, a few of them have shown promising results in controlling the infection. | 2020-06-26 |
| 32585855 | The clinical course was summarized, including the impact of drugs (angiotensin II receptor blockers [ARB], ibuprofen, and dipeptidyl peptidase-4 inhibitors [DPP4i]) and the therapeutic effect of lopinavir/ritonavir. | 2020-06-26 |
| 32586156 | Despite the direct effect on the routine of all life aspects, there are no clinical guidelines regarding phototherapy treatment during COVID-19 pandemic and as a result, phototherapies units continued to deliver this therapy for patients worldwide.Objective: We wish to explore the phototherapy utilization among dermatologic patients.Methods: We marked all patients that continue to arrive and being treated during COVID-19 pandemic.Results: From March more than 50% of patients stopped arriving to treatments due to the fear of COVID-19 infection.Conclusions: COVID-19 has a major implication on chronic dermatology treatments such as phototherapy. | 2020-06-26 |
| 32586205 | From 17 January 2020 to 24 January 2020, insomnia, anxiety and physical symptoms were evaluated online, and they were followed up for 4 and 8 weeks. […] In addition, insomnia, anxiety and physical symptoms were assessed at baseline and at the end of fourth and eighth weeks. […] After 8 weeks of follow-up, the differences in sleep status, anxiety symptoms and physical symptoms were statistically significant. | 2020-06-26 |
| 32586214 | Recent clinical data has highlighted that COVID-19 is associated with a significant risk of thrombotic complications ranging from microvascular thrombosis, venous thromboembolic disease and stroke. | 2020-06-26 |
| 32586218 | It was the middle of March when we were two weeks into our clinical rotation and just started to get the hang of the new hospital. […] When one morning after reaching the hospital and finishing our patient rounds and notes, we received a frantic message from our co-rotator, mentioning all clinical rotations for MD students have been suspended due to COVID-19, according to the new AMA guidelines. | 2020-06-26 |
| 32586323 | Demographic, clinical and biochemical data were extracted. […] Presenting clinical and biochemical features were consistent with those reported elsewhere. | 2020-06-28 |
| 32586327 | Preprint manuscripts, rapid publications and opinion pieces have been essential in permitting the lay press and public health authorities to preview data relating to coronavirus disease 2019 (COVID-19), including the range of clinical manifestations and the basic epidemiology early on in the pandemic. | 2020-06-28 |
| 32586336 | For individuals that were identified through contact tracing, we evaluate two procedures: monitoring individuals for symptoms onset and testing of individuals. | 2020-06-28 |
| 32586363 | Patients will be monitored for COVID-19 symptoms during the follow-up period. […] If signs or symptoms occur (fever, cough, shortness of breath), they will be examined and investigated with a high-resolution computed tomography (CT) scan of the lungs, COVID-19 specific IgM, IgG antibody assay and a nucleic acid amplification test (NAT) for the SARS-CoV-2 virus. […] This trial has been registered by the title of “Effect of Hydroxychloroquine on Novel Coronavirus Disease (COVID-19) prevention in cancer patients under treatment” in Iranian Registry of Clinical Trials (IRCT) with code “IRCT20200405046958N1”, https://www.irct.ir/trial/46946. | 2020-06-28 |
| 32586380 | The recent global pandemic has placed a high priority on identifying drugs to prevent or lessen clinical infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), caused by Coronavirus disease-2019 (COVID-19). […] While these findings are not yet ready for clinical translation, this report highlights the potential use of two bioinformatics technologies to rapidly discover existing therapeutic agents that warrant further investigation for established and emerging disease processes. | 2020-06-28 |
| 32586391 | Clinical research responses to outbreaks generate evidence to improve outcomes and outbreak control. […] Experiences from previous epidemics have identified multiple challenges to undertaking timely clinical research responses. […] This scoping review is a systematic appraisal of political, economic, administrative, regulatory, logistical, ethical and social (PEARLES) challenges to clinical research responses to emergency epidemics and solutions identified to address these. […] We included publications reporting PEARLES challenges to clinical research responses to emerging epidemics and pandemics and solutions identified to address these. […] The articles related to clinical research responses in Africa (n = 37), Europe (n = 8), North America (n = 5), Latin America and the Caribbean (n = 3) and Asia (n = 1) and/or globally (n = 22). […] Clinical trial networks and expedited funding and approvals were some solutions implemented. […] To strengthen global preparedness and response to the COVID-19 pandemic and future epidemics, identified solutions for rapid clinical research deployment, delivery, and dissemination must be implemented. | 2020-06-28 |
| 32586394 | Enoxaparin 70 IU/kg twice daily) compared to standard prophylactic dose (i.e., Enoxaparin 4000 IU once day), in hospitalized patients with COVID19 not requiring Invasive Mechanical Ventilation [IMV], are: a)more effective in preventing clinical worsening, defined as the occurrence of at least one of the following events, whichever comes first: 1. […] Primary Efficacy Endpoint: Clinical worsening, defined as the occurrence of at least one of the following events, whichever comes first: 1. […] Clinical worsening will be analysed as a binary outcome as well as a time-to-event one. […] The target sample size is based on the hypothesis that LMWH administered at high doses versus low doses will significantly reduce the risk of clinical worsening. […] Assuming an alpha of 5% (two tailed) and a percentage of patients who experience clinical worsening in the control group being between 25% and 30%, the study will have 80% power to detect at least 50% relative reduction in the risk of death between low and high doses of heparin. | 2020-06-28 |
| 32586395 | Patient already enrolled in a clinical trial using immunotherapeutic regimen for CoViD-194. | 2020-06-28 |
| 32586396 | Approximately 8 - 10 % of COVID-19 patients present with a serious clinical course and need for hospitalization, 8% of hospitalized patients need ICU-treatment. […] This has been routinely used in clinical practice in the EU for other conditions where a cytokine storm occurs and an observational study has just been completed on COVID-19 patients. […] An electronic randomization will be performed using the study software secuTrial® administered by the Clinical Study Center (CSC) of the Charité - Universitätsmedizin Berlin, Germany. […] The study was registered on April 27 2020 in the German Registry of Clinical Trials (DRKS) under the number DRKS00021447. | 2020-06-28 |
| 32586399 | Emerging experimental and clinical evidence reveals an evolutionary conserved action of thyroid hormone (TH) to adapt injured tissue to hypoxic conditions via its action on p38 MAPK, Akt signaling pathways. […] We aim to include two more clinical sites in the trial one from Greece and one from Germany INTERVENTION AND COMPARATOR: Intervention: T3 Solution for injection 10 μg/ml. | 2020-06-28 |
| 32586646 | At entry, all patients underwent a detailed clinical examination, 12-lead ECG, laboratory tests and arterial blood gas test. […] ECG was also recorded at discharge and in case of worsening clinical conditions. . […] ECG abnormalities were first detected after an average of about 30 days from symptoms’ onset (range 12-51 days). . | 2020-06-28 |
| 32586669 | The purpose of our study was to assess organ function in 102 patients with severe COVID-19 infections, using retrospective clinical analysis. […] The age, sex, underlying diseases, clinical laboratory data within 48h (routine blood tests, ALT, AST, TBIL, ALB, BUN, CR, D-Dimer, PT, APTT, FIB, F VIII:C, CK-MB, CK, and LDH), and ventilation status were collected. | 2020-06-28 |
| 32586739 | We performed a search in the PubMed databases, Web of Science, LILACS, MEDLINE, SciELO, and Cochrane Library using the keywords; COVID-19, Novel coronavirus, corona, 2019-nCoV, SARS-CoV-2, ENT, ear, nose, throat, otorhinolaryngology, ORL, pharynx, ORL, smell, larynx, different ENT related symptoms. | 2020-06-28 |
| 32586839 | Among patients who had cardiac injury, which we defined as an elevated level of cardiac troponin I (cTnI), we identified demographic and clinical characteristics associated with mortality and need for invasive ventilation. […] Chinese Clinical Trial Registry, No. | 2020-06-26 |
| 32586872 | We report the genome sequence of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolate obtained from a patient with symptoms of coronavirus disease 2019 (COVID-19) who was infected in Cali, Colombia. | 2020-06-26 |
| 32586897 | This case report highlights the neurotropism of SARS-CoV-2 in selected patients and emphasizes the importance of repeated lumbar punctures and CSF analyses in patients with suspected Covid-19 and neurological symptoms. | 2020-06-26 |
| 32586933 | An expert steering committee identified clinical questions on the use of IMT in patients with NIU during the COVID-19 pandemic. […] Consensus guidelines were proposed based on global expert opinion and practical experience to bridge the gap between clinical needs and the absence of medical evidence, to guide the treatment of patients with NIU during the COVID-19 pandemic. | 2020-06-28 |
| 32586958 | Herein, we detail the clinicoradiologic work-up and diagnosis, clinical course, and multidisciplinary medical management of this patient with COVID-19. | 2020-06-26 |
| 32586959 | Recognition of COVID-19-related leukoencephalopathy is important for appropriate clinical management, disposition, and prognosis. | 2020-06-26 |
| 32586960 | Patients with coronavirus disease 2019 (COVID-19) may have symptoms of anosmia or partial loss of the sense of smell, often accompanied by changes in taste. | 2020-06-26 |
| 32587077 | Various theories about drugs such as ACE inhibitors or angiotensin II receptor blockers (ARBs) in relation to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and clinical outcomes of COVID-19 are circulating in both mainstream media and medical literature. […] Therefore, clinical evidence is urgently needed. […] The aim of this study is to investigate the relationship between use of these drugs on clinical outcome of patients with COVID-19. | 2020-06-26 |
| 32587169 | The objective is to understand the feasibility, clinical profile and addressability of patients using teleconsultation in ophthalmology at a tertiary care government medical university during the COVID-19 Lockdown in India. | 2020-06-26 |
| 32587172 | Video calling was used in 14%, review of clinical photos shared was used in 53%. | 2020-06-26 |
| 32587174 | The aim of this study is to describe the demographics and clinical profile of patients with ocular disorders presenting during the novel coronavirus (COVID-19) lockdown in India. | 2020-06-26 |
| 32587179 | Medical records of the patients who underwent therapeutic penetrating keratoplasty (TPK) were reviewed. | 2020-06-26 |
| 32587625 | Severe acute respiratory syndrome-correlated new coronavirus (SARS-Cov-2) infection may result in neurological signs and symptoms through different mechanisms. | 2020-06-27 |
| 32587649 | There are several ongoing clinical trials related to the pharmacological choices of therapy for COVID-19 patients; however, drug trials related to observational studies so far have yielded mixed results and therefore have created a sense of confusion among healthcare professionals (HCPs). | 2020-06-27 |
| 32587651 | The infection mainly presents as fever, cough, and breathing difficulty, and few patients develop very severe symptoms. […] Several investigative drugs have been studied, drugs approved for other indications have been used, and several clinical trials are underway across the globe. | 2020-06-27 |
| 32587900 | Background: The COVID-19 pandemic has attracted the attention of researchers and clinicians whom have provided evidence about risk factors and clinical outcomes. | 2020-06-27 |
| 32587902 | We included studies with COVID-19 patients describing their symptoms; studies that compared smell and taste disorders between COVID-19 patients and otherwise healthy subjects; and studies comparing smell and taste disorders between COVID-19 severe and mild/moderate cases. […] People who reported loss of smell and taste had six-fold higher odds of being COVID-19 positive; similarly, anosmia and ageusia were associated with 10-fold higher odds of COVID-19 diagnosis. Conclusions: The frequency of smell and taste disorders is as high as other symptoms, thus, at least anosmia for which the definition was more consistent, could be included in lists of COVID-19 symptoms. | 2020-06-27 |
| 32587923 | They involve different domains of health sciences including virology, public health, clinical, critical care, and disaster management. […] This review addresses our current knowledge of COVID-19 pandemic from the basic virology and transmission, through prevention, infection control, clinical management, and finally disaster management including the recovery period. | 2020-06-27 |
| 32588051 | We collected epidemiological, demographic, clinical, laboratory, radiological and occupation information, along with contact history, of 671 patients with laboratory-confirmed COVID-19 reported from January 23 to February 5, 2020, in Henan province, China. […] Fourteen patients did not show any symptoms. | 2020-06-26 |
| 32588125 | The SARS-CoV‑2 causes a disease spectrum that includes asymptomatic and mildly symptomatic infections with subclinical manifestations but which can nevertheless still be potentially contagious. | 2020-06-28 |
| 32588191 | Common clinical manifestations of HLH are acute unremitting fever, lymphadenopathy, hepatosplenomegaly, and multiorgan failure. […] Due to a massive cytokine release, this clinical condition is considered as a cytokine storm syndrome. […] This paper aims to review the pathogenesis and the clinical picture of HLH, and its severe complication, the cytokine storm, with a special emphasis on the developed classification criteria sets for rheumatologists, since COVID-19 infection has clinical symptoms resembling those of the common rheumatologic conditions and possibly triggers HLH. | 2020-06-28 |
| 32588367 | According to the first obtained data, COVID-19 has defined with findings such as cough, fever, diarrhea, and fatigue although neurological symptoms of patients with COVID-19 have not been investigated in detail. […] Neurological symptoms are often seen in patients with COVID-19. […] It is suggested that determining these neurological symptoms prevents the diagnosis delay and helps to prohibit virus spread. | 2020-06-28 |
| 32588368 | A 45-item online survey (published from April 16 to 30, 2020), endorsed by the Italian Society of Clinical Neurophysiology (SINC), the Italian League Against epilepsy (LICE), and the Italian Association of Neurophysiology technologists (AITN), collected EEG management data (EEG’s number and type, indications, personnel and patients safety, devices’ sanification) during the Covid-19 pandemic. […] Patients executed hyperventilation only for real clinical needs, but often (56%) with a mask. | 2020-06-28 |
| 32588499 | Psychological therapists can respond creatively by addressing physical activity, a treatable clinical target which delivers both mental and physical health benefits. […] Physical activity is an important clinical target to sustain and improve mental health, especially in the current pandemic. | 2020-06-26 |
| 32588588 | Several studies described a few cases with initial ocular symptoms followed by systemic symptoms of the disease. […] Although the frequency of transmission of SARS-CoV-2 infection through the eye is low, ocular symptoms are not uncommon in COVID-19. […] In some cases, eye symptoms may be the first signs of illness. | 2020-06-26 |
| 32588589 | Symptoms of COVID-19 range from none (asymptomatic) to severe pneumonia and it can be fatal. […] Average progression times include: • in mild cases: from the onset of symptoms to recovery in almost 2 weeks; • in severe cases: from the onset of symptoms to recovery in 3-6 weeks, and from symptoms to death in 2-8 weeks. | 2020-06-26 |
| 32588593 | Based on analyses of the structure and work processes in Central Clinical Hospital (CCH) reconstructive strategic plan was developed. | 2020-06-26 |
| 32588614 | The case is presented of a 56-year-old man with respiratory tract symptoms, with twice negative results of real-time-reverse transcription-polymerase chain-reaction of nasopharyngeal swabs and positive chest computed tomography, with typical findings for COVID-19 pneumonia. | 2020-06-26 |
| 32588748 | Hospital clinicians have had to rapidly develop expertise in managing the clinical manifestations of COVID-19 including symptoms common at the end of life, such as breathlessness and agitation. | 2020-06-26 |
| 32588763 | Further complicating the picture is that the early signs and symptoms of dengue and COVID-19 could be similar, making it a risk that patients may be wrongly diagnosed early in the course of disease. | 2020-06-26 |
| 32588801 | This study aimed to evaluate the primary symptoms, comorbidities, and outcomes of inpatients with confirmed reverse transcription-PCR (RT-PCR) for SARS-CoV-2 infection among 2077 suspected/diagnosed cases of COVID-19. […] This study showed that some symptoms including cough and dyspnea, as well as abnormal CXR, could be proper predictors of positive RT-PCR result for SARS-CoV-2 infection. | 2020-06-26 |
| 32588943 | Although epidemiological and clinical characteristics of Covid-19 have been constantly reported, no article has systematically illustrated the role of obesity and diabetes in Covid-19, or how Covid-19 affects obesity and diabetes, or special treatment in these at-risk populations. | 2020-06-26 |
| 32589054 | It also explores the clinical opportunities in identifying these dissociated countertransferential experiences and embodying them in our own and our patients’ experiences. | 2020-06-26 |
| 32589146 | Recently, three randomized clinical trials on COVID-19 treatments were completed, one for lopinavir-ritonavir and two for remdesivir. […] The remdesivir trial of Wang et al. failed to reach the planned sample size due to a lack of eligible patients, while the bootstrap method was used to predict the quantity of clinical interest conditionally and unconditionally if the trial had continued to reach the originally planned sample size. […] Based on the statistical issues and lessons learned from the recent three clinical trials on COVID-19 treatments, we suggest more appropriate approaches for the design and analysis for ongoing and future COVID-19 trials. | 2020-06-26 |
| 32589164 | The aim of this study was to investigate the correlations between serum calcium and clinical outcomes in patients with coronavirus disease 2019 (COVID-19). […] In this retrospective study, serum calcium levels, hormone levels and clinical laboratory parameters on admission were recorded. […] The clinical outcome variables were also recorded. […] Patients with lower serum calcium levels (especially ≤2.0 mmol/L) had worse clinical parameters, higher incidences of organ injury and septic shock, and higher 28-day mortality. […] In conclusion, serum calcium was associated with the clinical severity and prognosis of patients with COVID-19. | 2020-06-26 |
| 32589165 | The recent publication of Cao et al in the NEJM[1] showed that lopinavir/ritonavir treatment did not accelerate clinical improvement compared with standard of care. | 2020-06-26 |
| 32589189 | To describe the clinical characteristics and outcomes in patients with MS and COVID-19 and identify factors associated with COVID-19 severity. […] COVID-19 diagnosed with a polymerase chain reaction test on a nasopharyngeal swab, thoracic computed tomography, or typical symptoms. […] The identification of these risk factors should provide the rationale for an individual strategy regarding clinical management of patients with MS during the COVID-19 pandemic. | 2020-06-26 |
| 32589258 | Demographic data, comorbidities, laboratory results and clinical outcomes were recorded. […] In the matched cohort (mean age 66.76 ± 15.7 years, 37.3% females), cTnI increase above the upper limit was present in 20.9% of the population and was associated with worse clinical outcomes, including all-cause mortality within 30 days (45.1% vs. | 2020-06-26 |
| 32589296 | Since then, this disease has rapidly spread across the globe and in March 2020 the World Health Organization (WHO) declared the COVID-19 pandemic.1 Since the outbreak was first announced, our journal has extensively focused on the clinical features, outcomes, diagnosis, immunology, and pathogenesis of COVID-19 and its infectious agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). | 2020-06-26 |
| 32589348 | The clinical impact of this benefit, however, may not be materially significant. | 2020-06-26 |
| 32589448 | Context Clinical autopsies have historically provided a fundamental contribution in the definition of the clinico-pathological basis of infectious diseases. […] Even though we are witnessing the decline of the clinical autopsy, its importance remains unchanged as it is the most exhaustive way to investigate diseases. […] The identification of the virus in postmortem tissues is a fundamental step in the definition of its clinical features. Objective To investigate the presence of Sars-CoV-2 in the postmortem with swabs. Design We performed postmortem swabs in 12 autopsy cases of patients with a clinical diagnosis of Sars-CoV-2 related pneumonia. […] We also performed a fifth swab on the parenchyma of both lungs in order to search for other viruses that could evolve in a clinical picture of interstitial pneumonia Results Overall we found that 9 out of 12 cases had at least one postmortem swab to be positive for Sars-CoV-2. | 2020-06-26 |
| 32589449 | A total of 52 ongoing clinical trials of CHM interventions for the treatment of COVID-19 were found. […] Clinical guidelines or health authorities from other countries do not provide advice on CHMs. […] A high number of clinical trials of different herbal products are being currently conducted in China. | 2020-06-26 |
| 32589456 | We reviewed epidemiologic studies that assessed the risk of mortality, hospital admissions, and symptoms/dysfunction associated with exposure to Asian dust. […] Seven of 12 studies reported reduced peak expiratory flow, and 16 of 21 studies reported increased respiratory symptoms associated with Asian dust exposure. | 2020-06-27 |
| 32589524 | Whilst challenges for knowledge and clinical skills are being actively addressed, wider considerations such as the impact on professional identity development have been mostly neglected thus far. […] We argue the current suspension of clinical placements holds the potential to negatively influence such identity acquisition. | 2020-06-26 |
| 32589531 | These demonstrate how the guidelines can be applied in a clinical setting, with particular focus on risk stratification and management. | 2020-06-26 |
| 32589537 | However, they may be protected from the features of hyperinflammation driven by a ‘cytokine storm’, so may have better clinical outcomes if infected. | 2020-06-26 |
| 32589539 | However, close contact with a COVID-19 patient, especially those displaying respiratory symptoms, is likely to increase the risk of transmission. | 2020-06-26 |
| 32589687 | HCWs with negative assays but progressive symptoms were re-tested for SARS-CoV-2. […] HCWs reporting three or more symptoms had an increased multivariate-adjusted odds of having positive assays, 1.95 (95% CI: 1.10-3.64), which increased to 2.61 (95% CI: 1.50-4.45) for six or more symptoms. […] Anosmia/ageusia (i.e. loss of smell/loss of taste) was reported less frequently (16%) than other symptoms by HCWs with positive assays, but was associated with more than a seven-fold multivariate-adjusted odds of a positive test: OR = 7.21 (95% CI: 2.95-17.67). […] The absence of symptoms or symptoms limited to nasal congestion/sore throat were associated with negative assays. | 2020-06-26 |
| 32589691 | Although previous studies have described the clinical aspects of COVID-19, few studies have focused on the early detection of severe COVID-19. […] Therefore, this study aimed to identify the predictors of severe COVID-19 and to compare clinical features between patients with severe COVID-19 and those with less severe COVID-19. […] Demographic information, initial symptoms, and first visit examination results were collected from the electronic medical records and compared between the groups. | 2020-06-26 |
| 32589756 | We analyzed 184 patients hospitalized for Covid-19 in Livingston, New Jersey for clinical characteristics associated with severe disease. | 2020-06-26 |
| 32589760 | The clinical course and the clinical findings were extracted from the medical record. […] Although transplanted patients might be more susceptible to an infection with SARS-CoV-2, their clinical course seems to be similar to immunocompetent patients. | 2020-06-26 |
| 32589774 | An improved understanding of risk factors for adverse clinical outcomes may shed some light on novel personalized approaches to optimize clinical care in vulnerable populations. | 2020-06-26 |
| 32589775 | Lyophilized formulation was evaluated for potential future use in clinical trials due to its storage stability in resource-limited settings. […] High intracellular concentrations of the active triphosphate (approximately 220 to 370- fold higher than the in vitro EC50 against SARS-CoV-2 clinical isolate) were achieved following infusion of 75 mg or 150 mg lyophilized formulation over 30 minutes or 2 hours. | 2020-06-26 |
| 32589799 | Regression results confirm these bivariate differences, and also reveal that risk factors (food insecurity, physical symptoms, and CES-D symptomatology) are positive and significantly related to suicidality (p < 0.000). | 2020-06-26 |
| 32589990 | This joint ESTRO-ASTRO practice recommendation established pragmatic and balanced consensus recommendations in common clinical scenarios of radiotherapy for lung cancer in order to address the challenges of the COVID-19 pandemic. | 2020-06-26 |
| 32590015 | Reports were divided into patients with known COVID-19, patients with “suspected” COVID-19 (having an order indication of respiratory or infectious signs or symptoms), and “unsuspected patients” (other order indications, eg, trauma or non-chest pain). | 2020-06-28 |
| 32590062 | Recently, ADE in SARS-CoV-2 has emerged as one hypothesis to explain severe clinical manifestations. | 2020-06-28 |
| 32590254 | Positive screens for psychological symptoms were common; 57% for acute stress, 48% for depressive, and 33% for anxiety symptoms. | 2020-06-28 |
| 32590297 | Our protocol allowed for all associated healthcare workers to continue their routine clinical work and daily life. | 2020-06-28 |
| 32590314 | There is an urgent necessity of sharing information to enable evidence-based decision making on the clinical management. […] There are no data on what physicians are doing on clinical practice in Latin American countries. to investigate current management opinion of Latin American MS and/or NMOSD expert neurologists based on their experience and recommendations. we developed a voluntary web-based survey based on hypothetical situations that these patients may encounter, while taking into account the potential risk of developing severe COVID-19 infection. 60% of the experts had the possibility of monitoring their patients by telemedicine. | 2020-06-26 |
| 32590324 | Epidemiology, risk factors, and clinical characteristics of COVID-19 patients have been identified, but the factors influencing the immune system against COVID-19 have not been well established. […] Pharmacologic inhibitors or antibodies specific to adenosinergic pathway components or adenosine receptors in microbial and tumor therapy have shown efficacy in pre-clinical studies and are entering the clinical arena. | 2020-06-28 |
| 32590335 | Cardiac biomarkers may also aid in triaging, risk-stratification, clinical decision-making, and prognostication of patients with COVID-19. | 2020-06-28 |
| 32590533 | The rapid spread of the disease created challenges for healthcare systems and forced healthcare workers to grapple with clinical and nonclinical stressors, including shortages of personal protective equipment, mortality and morbidity associated with COVID-19, fear of bringing the virus home to family members, and the reality of losing colleagues to the disease. | 2020-06-26 |
| 32590596 | Updated several times a week with posts by a wide variety of authors, AJN’s blog Off the Charts allows us to provide more timely-and often more personal-perspectives on professional, policy, and clinical issues. | 2020-06-27 |
| 32590751 | Sociodemographic characteristics and a set of measurement tools for mental and psychosocial problems for each subcohort including depression, anxiety, stress, resilient copings, neuroticism, perceived social support, wellbeing, somatic symptoms, insomnia, burnout (for healthcare workers), and public stigma toward COVID-19 infection (for the general population) will be collected. | 2020-06-26 |
| 32590755 | The aim of this study was to investigate the prevalence of sleep problems, depression and anxiety symptoms among conscripted frontline nurses fighting coronavirus disease 2019 (COVID-19) in Wuhan.This study was a cross-sectional study conducted with 100 frontline nurses. […] Sleep quality, depression, and anxiety symptoms were measured using the Pittsburgh sleep quality index (PSQI), the Generalized Anxiety Disorder 7-Item Scale (GAD-7) and the Patient Health Questionnaire-9 (PHQ-9), respectively.Mean sleep duration was 5.71 hours (SD = 1.09) and mean sleep latency was 33.49 minutes (SD = 28.87). […] Among 100 participants in this study, 60 (60%) had poor sleep quality, 46 (46%) suffered depression symptoms and 40 (40%) reported anxiety symptoms. […] Sleep quality (OR = 3.16, 95% CI: 1.17-8.52) and anxiety symptoms (OR = 8.07, 95% CI: 2.92-22.33) were significantly associated with depression symptoms. […] Depression symptoms (OR = 7.92, 95% CI: 2.89-21.73) were related to anxiety symptoms. […] Similarly, depression symptoms (OR = 3.24, 95% CI: 1.19-8.79) were associated with poor sleep quality.Sleep disturbance, depression, and anxiety symptoms are very common among frontline nurses who treating patients with COVID-19 in Wuhan, China. […] Comprehensive measures that involve psychosocial and personal behaviors should be implemented to improve sleep quality and prevent depression and anxiety symptoms. | 2020-06-26 |
| 32590775 | To compare clinical and imaging features between patients with an initial negative reverse-transcription-polymerase chain-reaction (RT-PCR) test and patients with an initial positive RT-PCR test. | 2020-06-26 |
| 32590779 | Targeted treatment and nursing methods should be performed based on patients’ actual situations in clinical practice. | 2020-06-26 |
| 32591152 | We developed a safety algorithm based on our clinical experience with MS and the available published evidence; the algorithm assists in the detection of contagious asymptomatic/presymptomatic cases and of patients with mild symptoms of SARS-CoV-2 infection with a view to withdrawing PIT in these patients and preventing new infections at day hospitals. […] We developed a clinical/microbiological screening algorithm consisting of a symptom checklist, applied during a teleconsultation 48hours before the scheduled session of PIT, and PCR testing for SARS-CoV-2 in nasopharyngeal exudate 24hours before the procedure. […] Systematic PCR testing, which provides the highest sensitivity for detecting presymptomatic cases, combined with early detection of symptoms of SARS-CoV-2 infection may reduce infections and improve detection of high-risk patients before they receive PIT. | 2020-06-27 |
| 32591163 | All children had an exact exposure history, family members with COVID-19, and “Mild/Moderate” symptoms at admission. […] Universal screening should be performed for people with a clear exposure history, even lacking apparent symptoms. | 2020-06-27 |
| 32591180 | In this work we aim to describe the clinical characteristics, treatment and outcome of pneumococcal infection in COVID-19 patients. […] Five patients with PCR confirmed COVID19 or clinical and radiological suspicion were diagnosed of pneumococcal infection. | 2020-06-27 |
| 32591283 | In this context, patients with cardiovascular disease should especially avoid being exposed to the virus, should not self-medicate and rapidly seek medical advice should they show symptoms of infection. | 2020-06-27 |
| 32591286 | Clinical signs help guide initial diagnosis, though definitive diagnosis is made using the laboratory technique reverse transcription polymerase chain reaction (RT-PCR). | 2020-06-27 |
| 32591408 | High serum levels of IL-6, IL-10 and an immune hyperresponsiveness referred to as a ‘cytokine storm’ have been associated with poor clinical outcome. | 2020-06-27 |
| 32591651 | Academic and clinical experts were consulted for additional input on virology, immunology, lipid biochemistry, microbicides as well as dental and clinical practice. | 2020-06-27 |
| 32591653 | There is some variation across the US but most schools have suspended clinical teaching and implemented stay at home policies. […] Others have implemented social distancing in laboratories including clinical skills. | 2020-06-27 |
| 32591655 | Design Case series.Introduction The most common signs and symptoms of SARS-CoV-2 infection include headache, sore throat, hyposmia, hypogeusia, diarrhoea, dyspnoea and pneumonia. […] Dermatological manifestations have also been reported but few authors have documented oral signs and symptoms. | 2020-06-27 |
| 32591660 | The authors provide information on the COVID-19 pandemic in order to inform front-line dentists.The paper is as essay on the available information relating to:Background to the pandemic• Coronaviruses in general• Pathogenesis• COVID-19• Clinical manifestations• Patient characteristics• Diagnosis• Protocol for managing the disease in the clinical setting• Transmission dynamics• Transmission dynamics in dentistry practice• Infection control• Mouth rinses• Rubber dam isolation• Anti-retraction handpiece• Appropriate disinfectants• Management of medical waste.Conclusions Face-to-face communication and consistent exposure to body fluids such as blood and saliva predispose dental care workers to risk of infection and there is high risk of cross-infection. | 2020-06-27 |
| 32591661 | The majority were aware of the symptoms of the disease and can identify affected patients. […] Nonetheless, 36.7% of dentists did not believe it to be a serious public health issue.Conclusions This group of Jordanian dentists was generally aware of COVID-19 symptoms and mode of transmission. […] Clinical practice guidelines should be made available to dentists by their associations during such crises. | 2020-06-27 |
| 32591666 | Data sources This review included 13 clinical studies (observational or clinical trial) which reported results of studies of the 2019 novel coronavirus (2019-nCoV). […] Most of the clinical studies were descriptive case series of patients who had contracted 2019-nCoV in China. […] Some review studies and clinical infection control protocols were also included to discuss the transmission patterns of 2019-nCoV from the oral cavity. […] Studies were not restricted to English language and they were not all full-text papers.Data extraction and synthesis A narrative synthesis of the results was conducted using distinct headings and subheadings, defined by the authors based on relevancy to the consensus about the importance of saliva with reference to 2019-nCoV.Results There was an inherent heterogeneity among the included clinical studies concerning their designs, sampling techniques, and the results about the diagnostic value of saliva. […] Whilst the viral peak was shown to be at onset of symptoms for 2019-nCoV, it can linger up to the tenth day after the appearance of symptoms for SARS-CoV. […] Finally, this paper warns about airborne transmission, particularly for close contacts.Conclusions Saliva can be proposed as an easily accessible diagnostic source although further clinical studies are required. | 2020-06-27 |
| 32591667 | Data sources This review article scrutinised 16 clinical studies (clinical trials and observational studies) concerning coronavirus disease of 2019 (COVID-19). […] The presentation section introduced the signs and symptoms, diagnosis, high risk groups, and complications of COVID-19. […] Besides the clinical guidelines presented within the study, it also encourages further up-to-date and evidence-based management guidelines for patients with COVID-19. | 2020-06-27 |
| 32591702 | The NHS is advising that frontline staff of BAME origin should be risk-assessed regarding their safety in working in clinical areas which are at risk of COVID-19. | 2020-06-27 |
| 32591713 | The article aims to provide additional and valuable frontline clinical information, experience and outcomes, including our categorisation of personal protective equipment used for varying face-to-face dental management during COVID-19. | 2020-06-27 |
| 32591762 | The transcriptional differences in critical cases compared to moderate cases likely contribute to clinical observations of heightened inflammatory tissue damage, lung injury and respiratory failure. | 2020-06-27 |
| 32591771 | Experimental and preclinical data should be integrated into a comprehensive analysis, where drug potency, the timing of therapy initiation, drug combinations, variability in systemic and local drug exposure and short- and long-term toxicities represent fundamental factors for the rational identification of candidates and prioritization of clinical investigations. | 2020-06-27 |
| 32591839 | Reports from Wuhan suggest that 36% of COVID-19 patients show neurological symptoms, and cases of viral encephalitis have been reported, suggesting that the virus is neurotropic under unknown circumstances. […] In order to understand why some patients develop such symptoms and others do not, we address herein the infectability of the central nervous system (CNS). | 2020-06-27 |
| 32591888 | We performed a single-centre retrospective study on COVID-19 patients hospitalised from January 25, 2020, to April 28, 2020, who received CT at admission prompted by respiratory symptoms such as dyspnea or desaturation. […] We collected patient’s clinical data including oxygenation support throughout hospitalisation. | 2020-06-27 |
| 32591890 | To investigate the imaging findings and clinical time course of COVID-19 pneumonia. […] The changes in the clinical and laboratory characteristics, imaging features, lesion-to-muscle ratio (LMR), and pulmonary inflammation index (PII) at baseline, 1-6 days, 7-13 days, and ≥ 14 days were compared. […] Of the 29 COVID-19 patients enrolled, the baseline chest CT scan was obtained 3 ± 2 (0-9) days after the onset of symptoms, and each patient had an average of 4 ± 1 (3-5) CT scans with a mean interval of 5 ± 2 (1-14) days. […] Lung lesion development on chest CT reflects the clinical time course of COVID-19 progression over 1-6 days, followed by clinical improvement and the resorption of lesions. […] • Unusual clinical time course of COVID-19 may indicate repeated chest CT. | 2020-06-27 |
| 32591970 | Substantial clinical improvement was obtained following a management plan, which included tocilizumab, hydroxychloroquine, prednisolone and enoxaparin sodium. […] The literature search revealed four articles reporting the clinical course of COVID-19 in seven rheumatic patients on secukinumab. […] The clinical course of SARS-CoV-2 infection was mild in most of these patients, while one of them experienced severe COVID-19. | 2020-06-27 |
| 32592113 | This altered immune profile may induce important clinical consequences, including increased susceptibility to lung infections; and enhanced local inflammatory response. […] Clinical studies should be designed to investigate this possibility. | 2020-06-27 |
| 32592118 | From 1 to 22 March 2020, patients with pneumonia symptoms, positive lung CT scan, and confirmed SARS-CoV-2 on reverse transcription-polymerase chain reaction (RT-PCR) were consecutively enrolled. […] Clinical data was collected. […] Multiple linear regression was used to predict VoD by clinical/laboratory data. […] Median duration of symptoms and C-reactive protein (CRP) was 5 days (range 1-30) and 4.94 mg/L (range 0.1-28.3), respectively. […] CT and clinical data together enable accurate prediction of short-term clinical outcome. | 2020-06-27 |
| 32592145 | We further plan to pursue the peptide in cell-based assays and eventually for clinical trials. | 2020-06-27 |
| 32592396 | The evidence of long-term clinical dynamic on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA re-positive case are less. […] We performed a 108 days follow-up on dynamic clinical presentations in a case, who hospitalized three times due to the positive recurrence of SARS-CoV-2 RNA after discharge, to understand the prognosis of the 2019-Coronavirus disease (COVID-19). […] In this case, positive SARS-CoV-2 recurred even after apparent recovery (normal CT imaging, no clinical symptoms, negative SARS-CoV-2 on stool sample and negative serum IgM test) from COVID-19, viral shedding duration lasted for 65 days, the time from symptom onset to disappearance was up to 95 days. | 2020-06-27 |
| 32592461 | The clinical features and outcomes of COVID-19 among immunosuppressed patients, who are at presumed risk for more severe disease but who may also have decreased detrimental inflammatory responses, are not well characterized. | 2020-06-27 |
| 32592496 | During the ongoing COVID-19 pandemic, there is a global concern about patients presenting with inflammatory syndrome with variable clinical features. | 2020-06-27 |
| 32592501 | A growing body of clinical data suggests that a cytokine storm is associated with COVID-19 severity and is also a crucial cause of death from COVID-19. | 2020-06-27 |
| 32592502 | In this study, retrospective analysis was used to explore the dynamic changes of serum IgM and IgG antibody and factors affecting diagnostic efficacy, so as to provide a theoretical basis for clinical diagnosis and treatment. | 2020-06-27 |
| 32592539 | Characteristics of blood coagulation and its relation to clinical outcomes in COVID-19 patients are still rarely reported. […] We aimed to investigate the blood coagulation function and its influences on clinical outcomes of patients with syndrome coronavirus 2 (SARS-CoV-2) infection. […] A certain correlation exists in coagulation disorder and adverse clinical outcome among severe COVID-19 patients. | 2020-06-27 |
| 32592550 | The use of face masks in public may not protect the general public from contracting the virus, however, presumptively decreases the viral load and contributes to a favourable clinical outcome in COVID-19 disease. | 2020-06-27 |
| 32592564 | The clinical effects and suggested mechanisms of action of rehabilitation technologies in patients with pneumonia, including those associated with the new COVID-19 coronavirus infection, are considered in Detail. […] The most studied of the physical methods that have a proven effect are physical exercises, breathing exercises, the complex effect of factors of resort therapy, hydrotherapy, which affect the main clinical manifestations of the underlying disease, astheno-neurotic syndrome and increasing immunity. […] Clinical recommendations for medical rehabilitation are proposed and its promising methods are considered. […] Regular generalization and analysis of high-quality randomized controlled clinical trials to evaluate various physical methods of treatment of patients with pneumonia associated with the new COVID-19 coronavirus infection is Necessary, which serve as a basis for the development of future valid clinical recommendations. | 2020-06-27 |
| 32592836 | Herein, we aimed to compare the clinical outcomes and imaging findings between COVID-19 patients with well-controlled diabetes and those with poorly-controlled diabetes. […] Clinical data and laboratory parameters were also collected from patients’ medical records. […] Based on the results, clinical outcomes and chest CT severity scores are similar between patients with well-controlled and poorly-controlled diabetes among the Iranian population with COVID-19. | 2020-06-27 |
| 32592843 | We aimed to explore the clinical characteristics and outcomes of COVID-19 patients presenting with combined DKA/HHS to our institution. […] To our knowledge, we are first to report the clinical characteristics and outcome in this group of patients. | 2020-06-27 |
| 32592903 | Epidemiological trajectory and clinical features of these COVID-19 cases were retrospectively retrieved from electronic medical records and valid individual questionnaire. | 2020-06-27 |
| 32593133 | Nevertheless, the assessment of clinical performances of available tests is urgently required as their use has just been initiated for diagnose. […] Two automated immunoassays (Abbott SARS-CoV-2 CLIA IgG and Euroimmun Anti-SARS-CoV-2 ELISA IgG/IgA assays) and one lateral flow immunoassay (LFIA NG-Test® IgG-IgM COVID-19) were tested. 293 specimens were analyzed from patients with a positive RT-PCR response, from patients with symptoms consistent with COVID-19 but exhibiting a negative response to the RT-PCR detection test, and from control group specimens. […] Days since symptoms onset were collected from clinical information sheet associated with respiratory tract samples. […] Sensitivity for IgG detection, >14 days after onset of symptoms, was 100.0 % for all assays. […] Excellent sensitivity for IgG detection was obtained >14 days after onset of symptoms for all immunoassays. […] Our study shows that NG-Test® is reliable and accurate for routine use in clinical laboratories. | 2020-06-27 |
| 32593180 | Whilst SARS-CoV-2 infection in the early stages of infection has been well described, less is known about the development of antibodies to SARS-CoV-2, clearance of RNA shedding and clinical outcome of COVID-19. | 2020-06-27 |
| 32593183 | Whilst the majority of patients with COVID-19 infection have mild self-limiting symptoms, for some the SARS-CoV2 virus can trigger a severe hyperinflammatory syndrome which is life threatening. | 2020-06-27 |
| 32593196 | Delirium caused by hypoxia, a prominent clinical feature of COVID-19, may increase the need for treatment of Alzheimer’s disease (AD) patients (1). | 2020-06-27 |
| 32593209 | In conclusion, our report provides clinical evidence that ruxolitinib treatment is feasible and can be beneficial in patients with COVID-19 pneumonia, preventing cytokine storm and ARDS. | 2020-06-27 |
| 32593339 | Significant risk factors for requiring ICU admission in multivariable analyses were being younger than 1 month (odds ratio 5·06, 95% CI 1·72-14·87; p=0·0035), male sex (2·12, 1·06-4·21; p=0·033), pre-existing medical conditions (3·27, 1·67-6·42; p=0·0015), and presence of lower respiratory tract infection signs or symptoms at presentation (10·46, 5·16-21·23; p<0·0001). | 2020-06-29 |
| 32593341 | Comprehensive characterisation of clinical syndromes is crucial to allow rational selection and evaluation of potential therapies. […] Broad clinical syndromes associated with COVID-19 were classified as a cerebrovascular event (defined as an acute ischaemic, haemorrhagic, or thrombotic vascular event involving the brain parenchyma or subarachnoid space), altered mental status (defined as an acute alteration in personality, behaviour, cognition, or consciousness), peripheral neurology (defined as involving nerve roots, peripheral nerves, neuromuscular junction, or muscle), or other (with free text boxes for those not meeting these syndromic presentations). […] Physicians were encouraged to report cases prospectively and we permitted recent cases to be notified retrospectively when assigned a confirmed date of admission or initial clinical assessment, allowing identification of cases that occurred before notification portals were available. […] During this period, the platforms received notification of 153 unique cases that met the clinical case definitions by clinicians in the UK, with an exponential growth in reported cases that was similar to overall COVID-19 data from UK Government public health bodies. […] Complete clinical datasets were available for 125 (82%) of 153 patients. 77 (62%) of 125 patients presented with a cerebrovascular event, of whom 57 (74%) had an ischaemic stroke, nine (12%) an intracerebral haemorrhage, and one (1%) CNS vasculitis. 39 (31%) of 125 patients presented with altered mental status, comprising nine (23%) patients with unspecified encephalopathy and seven (18%) patients with encephalitis. […] The remaining 23 (59%) patients with altered mental status fulfilled the clinical case definitions for psychiatric diagnoses as classified by the notifying psychiatrist or neuropsychiatrist, and 21 (92%) of these were new diagnoses. | 2020-06-29 |
| 32593418 | Clinical and diagnostic details of cardiovascular involvement in these patients are mostly limited to biochemical markers. […] Multiple therapeutic agents have been tried with questionable efficacy and without clinical evidence. […] With an increasing number of patients, newer promising therapies, and ongoing clinical trials, the exact mechanisms and extent to which these risk factors contribute to outcomes will be clearer in the future. | 2020-06-29 |
| 32593519 | In this scope competent authorities are responsible to set up certain principles and criteria for the collection and clinical use of COVID-19 Convalescent Plasma (CCP). […] The first part encompasses the supply of CCP and the second part lead the clinical use of CCP for the treatment of patients with severe COVID-19 infection. […] Turkish Ministry of Health developed a guide on collection and clinical use of CCP and created a web-based monitoring system to follow-up the patients treated with convalescent plasma in universal. | 2020-06-29 |
| 32593563 | Transitioning toward virtual practice, particularly during a pandemic, prepares for the possibility of healthcare workers being quarantined but still able to provide care and minimizes exposure to asymptomatic patients or those with atypical symptoms. | 2020-06-29 |
| 32593564 | Thirty-five percent of participants experienced any COVID-19-related symptoms from February to April 2020, but less than 5% of them got tested, and only 46% stayed home exclusively while experiencing symptoms. | 2020-06-29 |
| 32593608 | The presence of comorbidities or symptoms at the time of sample collection was a risk factor for infection, but working as a physician/nurse was not a risk factor. […] Universal screening in high-risk units, irrespective of symptoms, allowed the identification of asymptomatic and potentially contagious infected workers, enabling them to self-isolate for 7 days. | 2020-06-29 |
| 32593613 | Here we argue that the oral route of administration of quercetin is unlikely to be effective in clinical trials owing to biotransformation during digestion, absorption and metabolism, but suggest that agents could be administered directly by alternative routes such as a nasal or throat spray. | 2020-06-29 |
| 32593614 | The prevalence of clinical insomnia during the outbreak was 20.05% (1131) according to the ISI. […] The factors of satisfaction with the current sleep pattern and how perceptible the symptoms of the current sleep pattern are to other people (p < 0.05) and the middle (difficulty staying asleep) and terminal (waking up too early) (p < 0.01) factors of the ISI were significantly different across groups. | 2020-06-29 |
| 32593648 | However, epidemiologic and clinical data are scarce. | 2020-06-29 |
| 32593741 | The aim was to guide clinical microbiologists in the use of these diagnostic tests and clinicians in the interpretation of their results. […] On the other hand, notwithstanding its varying sensitivity according to the time of infection, serology represents a valid asset (a) to try to solve possible discrepancies between a highly suggestive clinical and radiological presentation and negative RT-PCR, (b) to solve discrepancies between different PCR assays and (c) for epidemiological purposes. | 2020-06-29 |
| 32593742 | The aim was to determine the clinical characteristics of COVID-19 patients because the SARS-CoV-2 virus continues to circulate in the population. […] Demographic, clinical characteristics, clinical outcomes and duration of viral shedding were analysed. | 2020-06-29 |
| 32593770 | Patients without clinical suspicion for COVID-19 were not tested. | 2020-06-29 |
| 32593809 | From December 7, 2016 to May 7, 2017, 50 staff participants from 2 pLTCFs received weekly text or email requests to report the presence or absence of ARI symptoms. […] Those who fulfilled the ARI case definition (≥2 symptoms) had respiratory specimens collected to detect viruses by reverse transcriptase polymerase chain reaction assays. […] Pre- and postsurveillance respiratory specimens were collected to assess subclinical viral shedding. | 2020-06-29 |
| 32593867 | We retrospectively report the clinical management of 3,737 screened patients, including 3,119 (83.5%) treated with HCQ-AZ (200 mg of oral HCQ, three times daily for ten days and 500 mg of oral AZ on day 1 followed by 250 mg daily for the next four days, respectively) for at least three days and 618 (16.5%) patients treated with other regimen (“others”). […] We performed 2,065 low-dose computed tomography (CT) scans highlighting lung lesions in 592 of the 991 (59.7%) patients with minimal clinical symptoms (NEWS score = 0). […] Clinical factors (age, comorbidities, NEWS-2 score), biological factors (lymphocytopenia; eosinopenia; decrease in blood zinc; and increase in D-dimers, lactate dehydrogenase, creatinine phosphokinase, troponin and C-reactive protein) and moderate and severe lesions detected in low-dose CT scans were associated with poor clinical outcome. […] Although this is a retrospective analysis, results suggest that early diagnosis, early isolation and early treatment of COVID-19 patients, with at least 3 days of HCQ-AZ lead to a significantly better clinical outcome and a faster viral load reduction than other treatments. | 2020-06-29 |
| 32593875 | As SARSCoV-2 with strong transmissibility and pathogenicity, it has become a professional consensus that clinical samples from suspected patients should be heat inactivated at 56°C for 30 min before further processing. […] However, previous studies on the effect of inactivation on qualitative real-time RT-PCR were conducted with diluted samples rather than clinical samples. […] The aim of this study was to investigate whether heat inactivation on clinical samples before detection will affect the accuracy of qualitative real-time RT-PCR detection. […] Heat-Inactivation has significantly influenced the qualitative detection results on clinical samples, especially weakly positive samples. […] The results indicate the urgency to establish a more suitable protocol for COVID-19 clinical sample’s inactivation. | 2020-06-29 |
| 32593935 | New clinical approaches are needed to minimize complications of gestational diabetes during the COVID-19 outbreak with timely screening and proper management. […] The present study aims to highlight changes in the clinical guideline for gestational diabetes during the pandemic. […] Updated temporary changes in clinical guidelines are sensible and accommodates social distancing and minimizes risk of exposure to COVID-19. | 2020-06-29 |
| 32594116 | Patients recovering from coronavirus disease 2019 (COVID-19) often continue to test positive for the causative virus by PCR even after clinical recovery, thereby complicating return-to-work plans. […] The only variable significantly associated with viral load was time since onset of symptoms. | 2020-06-29 |
| 32594121 | However, it is not known if such practices can change the clinical course in infected individuals. […] Viral inoculum during infection or mode of transmission may be key factors determining the clinical course of COVID-19. | 2020-06-29 |
| 32594142 | Clinical trials of pharmacologic treatments of coronavirus disease 2019 (COVID-19) are being rapidly designed and implemented in adults. | 2020-06-29 |
| 32594151 | We reported the first confirmed infant case of co-infection with SARS-CoV-2 and Citrobacter koseri urinary infection in 6-week-old child admitted on 25 March 2020 with mild symptoms in the Pediatric COVID Unit of Amiens University Hospital, France. | 2020-06-29 |
| 32594164 | There have been limited data regarding the clinical impact of COVID-19 disease on people with HIV (PWH). […] We collected data on baseline clinical characteristics, laboratory values, HIV infection status, COVID-19 treatment, and outcomes from this group and matched comparators (one PWH to up to five patients by age, sex, race/ethnicity and calendar week of infection). […] We compared baseline clinical characteristics and outcomes (death, mechanical ventilation, hospital discharge) for these two groups, as well as cumulative incidence of death by HIV status. | 2020-06-29 |
| 32594170 | False-negative severe acute respiratory syndrome coronavirus 2 test results can negatively impact the clinical and public health response to coronavirus disease 2019 (COVID-19). | 2020-06-29 |
| 32594272 | We found enthusiasm for discreet, free, home-based testing and uncovered an unmet need for HIV testing as clinical and outreach programs shuttered in Oregon. | 2020-06-29 |
| 32594325 | The association with possible predictors, including clinical features and type of virus infection, was assessed using uni- and multivariable analyses. | 2020-06-29 |
| 32594562 | Since coronavirus disease 2019 (COVID-19) emerged in Wuhan, China in December 2019 and spread around the world, over 1100 clinical studies have been registered globally on clinical trials registries, including over 500 randomised controlled trials. […] Such rapid development and launch of clinical trials is impressive but presents challenges, including the potential for duplication and competition. […] In order to focus on those studies most likely to influence clinical practice, we summarise the 31 currently registered randomised trials with a target sample size of at least 1000 participants. […] The most common therapeutic agent being trialled currently is hydroxychloroquine (24 trials with potential sample size of over 25 000 participants), followed by lopinavir-ritonavir (seven trials) and remdesevir (five trials) There are many candidate drugs in pre-clinical and early phase development, and these form a pipeline for future large clinical trials if current candidate therapies prove ineffective or unsafe. | 2020-06-29 |
| 32594570 | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) not only infects the gastrointestinal (GI) tract and causes GI symptoms, but also increases nosocomial transmission risk during endoscopic procedures for aerosol generation. | 2020-06-29 |
| 32594572 | The skin lesions were polymorphic, and erythema, chilblain-like and urticarial lesions were most common, occurring on an average of 9.92 days (range: 1-30) after the onset of systemic symptoms. […] Our review systematically presented the clinical characteristics of 507 patients and showed that skin might be the potential target of the infection according to ACE2 expression. | 2020-06-29 |
| 32594751 | The number of days with symptoms prior to presentation was significantly shorter in group 1 compared with group 2 (3 vs 4, p = 0.04). | 2020-06-30 |
| 32594865 | Alongside clinical placements, medical students are familiar with online teaching platforms from various members of the faculty. | 2020-06-30 |
| 32594909 | Combining census estimates and hospital capacity data from ONS and NHS at the Administrative Region, Ceremonial County (CC), Clinical Commissioning Group (CCG) and Lower Layer Super Output Area (LSOA) level from England and Wales, we calculate the number of individuals at risk of COVID-19 hospitalization. | 2020-06-30 |
| 32594928 | Ninety-five per cent of symptomatic cases showed symptoms by 13.7 days (95% CI 12.5-14.9). | 2020-06-30 |
| 32594937 | This study aims to synthesise case fatality rate (CFR) among confirmed COVID-19 patients, incubation period and time from onset of COVID-19 symptoms to first medical visit, intensive care unit (ICU) admission, recovery, and death. […] The pooled mean number of days from the onset of COVID-19 symptoms to first clinical visit was 4.92 (95% CI: 3.95, 5.90), ICU admission was 9.84 (95% CI: 8.78, 10.90), recovery was 18.55 (95% CI: 13.69, 23.41), and death was 15.93 (95% CI: 13.07, 18.79). […] We found that the incubation period and lag between the onset of symptoms and first clinical visit for COVID-19 are longer than other respiratory viral infections including Middle East respiratory syndrome and severe acute respiratory syndrome; however, the current policy of 14 days of mandatory quarantine for everyone potentially exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might be too conservative. | 2020-06-30 |
| 32595054 | To analyze differences by age group in anxiety, depression, loneliness and comorbid anxiety and depression in young people, middle aged adults and older adults during the lock-down period at home due to the COVID-19 pandemic, and to explore the association between negative self-perceptions of aging and psychological symptoms controlling by age group. | 2020-06-30 |
| 32595355 | One of the important SARS-CoV-2 targets namely type 2 transmembrane serine protease (TMPRSS2) was screened with NPC’s NIH small molecule library which includes approved drugs by FDA and compounds in clinical investigation. […] If these results can be validated by in vitro and in vivo studies, benzquercin can be considered to be used as inhibitor of TMPRSS2 at the clinical studies. | 2020-06-30 |
| 32595361 | Although SARS-CoV-2 mainly causes lung infection, gastrointestinal symptoms described in COVID-19 patients and detection of the viral RNA in feces of infected patients drove attentions to a possible fecal-oral transmission route of SARS-CoV-2. | 2020-06-30 |
| 32595362 | MSC EVs are being tested in preclinical and clinical settings where they exhibit exceptional immunosuppressivecapacity. […] In this review, we present the outcomes of preclinical and clinical studies utilizing MSC EVs as therapeutic agents for the treatment of a wide variety of immunological disorders. | 2020-06-30 |
| 32595613 | Human enteroviruses are responsible for diverse diseases, from mild respiratory symptoms to fatal neurological complications. […] Currently, no registered antivirals have been approved for clinical therapy. […] Currently, remdesivir is under phase 3 clinical development for disease COVID-19 treatment. | 2020-06-30 |
| 32595653 | We have found epidemiological evidence, based on recent clinical SARS-CoV-2 studies in China, that suggest that smokers are statistically less likely to be hospitalized. | 2020-06-30 |
| 32595762 | Although most COVID-19 patients present with respiratory symptoms, some present with gastrointestinal (GI) symptoms like diarrhoea, loss of appetite, nausea/vomiting and abdominal pain as the major complaints. […] Moreover, GI infection could be the first manifestation antedating respiratory symptoms; patients suffering only digestive symptoms but no respiratory symptoms as clinical manifestation have also been reported. […] Thus, the implications of digestive symptoms in patients with COVID-19 is of great importance. | 2020-06-30 |
| 32595811 | Cardiac catheterization volume, as well as clinical and procedural characteristics of patients undergoing cardiac catheterization, was compared before and during the COVID-19 pandemic. | 2020-06-30 |
| 32595812 | Although coronavirus disease 2019 (COVID-19) manifests in most cases with respiratory symptoms, other presentations can occur. | 2020-06-30 |
| 32595843 | Allocating residents and fellows into skill-concordant clinical roles, however, is challenging. […] We designed a categorization schema that can efficiently facilitate clinical and educational horizontal care delivery for trainees within a given institution. | 2020-06-30 |
| 32595947 | SARS-CoV-2 infection in humans is characterized by symptoms such as fever and dyspnea accompanied by infrequent incidence of lymphopenia, gastrointestinal complications such as elevated hepatic aminotransferases, and diarrhea. […] In this review, we have provided a picture of SARS-CoV-2 epidemiological characteristics, the clinical symptoms experienced by patients of varying age groups, the molecular virology of SARS-CoV-2, and the treatment regimens currently employed for fighting SARS-CoV-2 infection as well as their outcomes. | 2020-06-30 |
| 32595955 | In contrast, the widely spread human coronaviruses OC43, HKU1, 229E, and NL63 tend to cause only mild symptoms. | 2020-07-31 |
| 32595962 | Background: TDR, The Special Programme for Research and Training hosted at the World Health Organization, has long supported Low- and Middle-Income Countries in strengthening research capacity through three training programmes: the Postgraduate Training Scheme (PGTS), the Clinical Research and Development Fellowship (CRDF), and the Structured Operational Research Training InitiaTive (SORT IT). […] Skills were being applied in various areas of the emergency response, including: emergency preparedness, situation analysis/surveillance, infection control and clinical management, data generation, mitigating the effect of COVID on the health system, and research. […] Depending on the type of training programme, 26-74% were involved in implementation, operational or clinical research. | 2020-07-02 |
| 32595974 | We present a case of SARS-COV2 pneumonia with septic shock and multi-organ failure that demonstrated significant clinical improvement after therapeutic plasma exchange. […] Given her worsening sepsis with multi-organ failure, she underwent therapeutic plasma exchange with rapid clinical improvement. | 2020-06-30 |
| 32596046 | For clinical validation, 300 throat swab and 100 sputum clinical samples were examined by both the BD MAX platform and in-house real-time RT-PCR methods, which showed 100% concordant results. | 2020-06-30 |
| 32596068 | COVID-19 spreads from the aerosols of an infected individual whether they are showing any symptoms or not. | 2020-06-30 |
| 32596069 | Clinical presentation and severity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) varies greatly amongst patients, as supported by recent literature. […] Here, we would like to describe a case of acute bilateral pulmonary embolism (PE) presenting with atypical gastrointestinal symptoms in a patient with SARS-CoV-2 infection. […] This atypical presentation of PE is unique to our case and highlights the significance of a high index of clinical suspicion for SARS-CoV-2 and its associated thrombogenic effect, even in patients with atypical symptoms. | 2020-06-30 |
| 32596073 | The spread of cutaneous lesions and the onset of neurological symptoms suggested a cryptococcal disease, which was confirmed by lumbar puncture and cutaneous biopsy. | 2020-06-30 |
| 32596078 | The exact mechanism and efficacy of current candidate drugs are still being explored through clinical trials. […] This review explores various drugs and their mechanism of action which are either currently being used in clinical trials or may be used in the future for the treatment of COVID-19. | 2020-06-30 |
| 32596244 | Therefore, in this review, we summarize the mounting evidence obtained from preclinical studies using animal models of lethal pneumonia where curcumin exerts protective effects by regulating the expression of both pro- and anti-inflammatory factors such as IL-6, IL-8, IL-10, and COX-2, promoting the apoptosis of PMN cells, and scavenging the reactive oxygen species (ROS), which exacerbates the inflammatory response. | 2020-06-30 |
| 32596248 | Background: On 29th December 2019, a cluster of cases displaying the symptoms of a “pneumonia of unknown cause” was identified in Wuhan, Hubei province of China. […] This systematic review and meta-analysis aims to review the epidemiological and clinical characteristics of COVID-19 cases in the early phase of the COVID-19 pandemic. […] A total of 533 adult patients with pooled median age of 56 (95% CI: 49-57) and a pooled prevalence of male of 60% (95% CI: 52-68%) were admitted to hospital at a pooled median of 7 days (95% CI: 7-7) post-onset of symptoms. […] The most common symptoms at admission were fever, cough and fatigue, with a pooled prevalence of 90% (95% CI: 81-97%), 58% (95% CI: 47-68%), and 50% (95% CI: 29-71%), respectively. […] Conclusion: This study highlights the key epidemiological and clinical features of COVID-19 cases during the early phase of the COVID-19 pandemic. | 2020-06-30 |
| 32596339 | The dynamic changes of DD, PT, APTT, and Fg were tested, and the correlation with CT imaging, clinical classifications, and prognosis was studied. […] The levels of DD and Fg were correlated with clinical classification. | 2020-06-30 |
| 32596354 | With a similarity in clinical as well as laboratory findings, there is a need to differentiate these two conditions on chest CT scan. | 2020-06-30 |
| 32596489 | Practices and recommendations made in this document are intended to support safe clinical practice and efficient use of resources during this challenging time. | 2020-06-30 |
| 32596640 | The prevalence of symptoms of anxiety, depression, insomnia and the overall psychological problems in healthcare workers during the COVID-19 pandemic in China was 46.04%, 44.37%, 28.75% and 56.59%, respectively. | 2020-06-30 |
| 32596641 | Thirty medical and nursing staff members with symptoms of insomnia were instructed to wear medical ring-shaped pulse oximeters to monitor their sleep overnight. | 2020-06-30 |
| 32596829 | Xenotransplantation has the potential to offer unlimited availability of pig organs for transplantation, and pig-to-non-human primate models have demonstrated outcomes that may soon justify clinical trials. […] While most experts believe that zoonosis is manageable, apprehension over disease transmission from animal donors to human recipients remains a frequent concern of many who are undecided or opposed to clinical xenotransplantation. | 2020-06-30 |
| 32596894 | The offensive or proactive approach consists of two parts: The first part is to preemptively establish a barrier between a novel virus and humans in order to prevent the spillover of the virus into humans, and the second part is that, when a spillover fails to be prevented, we should take public interventions, such as contact tracing, social distancing, and quarantine and isolation, as early as when there are several dozens or one hundred or more cases that manifest symptoms with an unknown etiology in order to prevent an epidemic that is still limited to relatively small groups from developing into an outbreak. | 2020-06-30 |
| 32596895 | Answering this involved, in part, finding new ways for our team of clinical ethicists to support the clinicians caring for Mrs. | 2020-06-30 |
| 32596896 | This essay argues that racial health and health care disparities, rooted as they are in systemic injustice, ought to carry far more weight in clinical ethics than they generally do. | 2020-06-30 |
| 32596910 | Her intensivist had requested a clinical ethics consultation for potentially inappropriate medical treatment-in my world of clinical ethics consultation, routine stuff. | 2020-06-30 |
| 32597046 | Early intervention for high-risk patients can thereby improve clinical outcomes in COVID-19 patients. | 2020-06-30 |
| 32597047 | The most frequent symptoms at the time of admission were fever (58%), cough (52%), and fatigue or myalgia (19%). […] As a result, more conservative approaches might be preferred in children for the diagnostic, clinical, and even therapeutic applications. | 2020-06-30 |
| 32597076 | In a short period of time, Chinese medical workers have experienced the gradual understanding, evidence accumulation and clinical practice of the unknown virus. | 2020-06-30 |
| 32597101 | The COVID-19 pandemic influenced the normal course of clinical practice leading to significant delays in the delivery of healthcare services for patients non affected by COVID-19. | 2020-06-30 |
| 32597102 | The most common symptoms observed in COVID-19 patients before hospitalization may be fever, chills, cough, dyspnea, asthenia, myalgia and/or arthralgia. | 2020-06-30 |
| 32597103 | COVID-19 pandemic strongly modified the organizations of our clinical practice. | 2020-06-30 |
| 32597315 | SARS-CoV-2 papain-like protease (PLpro) was used to virtually screen 1697 clinical FDA-approved drugs. […] The objective of drug repurposing is the rapid relocation of safe and approved drugs by bypassing the lengthy pharmacokinetic, toxicity, and preclinical phases. […] The list of the drugs provided herein constitutes a primer for clinical application in COVID-19 patients and guidance for further antiviral studies.Communicated by Ramaswamy H. | 2020-06-30 |
| 32597466 | Baricitinib for the treatment of COVID-19 should be further investigated in randomized controlled clinical trials. | 2020-06-30 |
| 32597503 | Reduced intracellular GSH levels and glutathione reductase (GR) activity in the neutrophils during clinical conditions like autoimmune disorders, neurological disorders, diabetes, and microbial infections lead to dysfunctional neutrophils. […] However, further studies are indispensable to address the clinical usage of melatonin. | 2020-06-30 |
| 32597550 | To the extent that there is still a lack of knowledge about the clinical characteristics, evolution, and prognosis of SARS-CoV-2 infection in kidney transplant recipients, we will report the first 5 cases diagnosed and followed in our transplant unit, as well as share the therapeutic strategies adopted. | 2020-06-30 |
| 32597578 | The aim of this study was to analyze the symptoms of depression, anxiety, and stress in urologists during the COVID-19 pandemic. 90 urologists aged 25 to 60 years (M=37.27, S.D. […] The results of this study can be used in selection of therapeutic targets for psychotherapy, administered to doctors; in prevention of symptoms of anxiety, stress and depression among doctors; and in professional selection of doctors for working in crisis situations. | 2020-06-30 |
| 32597823 | Covid-19 is the acute illness caused by SARS-CoV-2 with initial clinical symptoms such as cough, fever, malaise, headache, and anosmia. […] Although therapies selectively down-regulating both AhR and IDO1 are currently lacking, medications in clinical use such as dexamethasone may down-regulate both AhR and IDO1 genes, as calcitriol/vitamin D3 may down-regulate the AhR gene, and tocopherol/vitamin E may down-regulate the IDO1 gene. | 2020-06-30 |
| 32597925 | This perspecitve may be especially important to study among adolescents, who are less likely to experience severe symptoms but contribute to the spread of the virus. | 2020-06-30 |
| 32597954 | COVID-19 affects millions of patients worldwide, with clinical presentation ranging from isolated thrombosis to acute respiratory distress syndrome (ARDS) requiring ventilator support. […] Thus, NETs triggering immunothrombosis may, in part, explain the prothrombotic clinical presentations in COVID-19, and NETs may represent targets for therapeutic intervention. | 2020-06-30 |
| 32598204 | Background: There is concern about susceptibility of psoriatic patients on biologics to coronavirus disease 2019 (COVID-19) and its clinical course.Purpose: The aims of present review were to determine whether the biologic treatment of psoriasis increases the risk of SARS-CoV-2 infection and if biologics affect the clinical course of COVID-19 in these patients.Methods: We searched database of MEDLINE (PubMed) for key term of psoriasis biologic and COVID-19 until June 9, 2020 and all published 14 papers and an experience from Iran (10509 cases) related to the psoriatic patients on biologics and COVID-19 along with relevant papers were summarized. […] Reports indicated psoriatic patients on biologics were not more susceptible to COVID-19 and the severe clinical course of disease.Conclusion: While there is not definitive controlled trial data, the available evidence suggests that patients with psoriasis without COVID-19 can continue the biologic therapy for psoriasis. | 2020-06-30 |
| 32598302 | In this multicenter retrospective study, routine laboratory parameters (C-reactive protein, lactate dehydrogenase, ferritin, absolute neutrophil and lymphocyte counts), demographic data and the chest X-ray/CT result from 967 patients entering the ED with respiratory symptoms were collected. […] This algorithm provides the means for medical professionals to rapidly evaluate SARS-CoV-2 infection status of patients presenting at the ED with respiratory symptoms. | 2020-06-30 |
| 32598303 | All participants were tested with PCR against SARS-CoV-2 at a clinical microbiology laboratory. | 2020-06-30 |
| 32598305 | Although some demographic, clinical and environmental factors have been associated with a higher risk of developing coronavirus disease 2019 (COVID-19) and progressing towards severe disease, altogether these variables do not completely account for the different clinical presentations observed in patients with comparable baseline risk, whereby some subjects may remain totally asymptomatic, whilst others develop a very aggressive illness. | 2020-06-30 |
| 32598306 | A milder clinical course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been anecdotally reported over the latest phase of COVID-19 pandemic in Italy. […] In this regard, the clinical severity of COVID-19 could be attenuated by mutations in SARS-CoV-2 genome that decrease its virulence, as well as by lower virus inocula. […] This pilot study prompts further investigation on the correlation between SARS-CoV-2 load and different clinical manifestation of COVID-19 during different phases of the pandemic. | 2020-06-30 |
| 32598438 | Alongside efforts to reconfigure services and enable continued delivery of safe clinical care for patients with IBD, consideration must also be given to management of IBD research activity. […] In many centres there has been an effective shutdown of IBD clinical trial activity as research sites have switched focus to either COVID-19 related research or clinical care only. […] Moreover, in many countries research activity has become embedded into clinical care - with clinical trials often providing access to new therapies or strategies - which would otherwise not have been available in standard clinical pathways. […] This pandemic has significant implications for the design, conduct, analysis and reporting of clinical trials in IBD. […] In this Viewpoint, we share our experiences from a clinical and academic perspective in the United Kingdom, highlighting the early challenges encountered and consider implications for patients and staff at research sites, sponsors, research ethics committees, funders and regulators. | 2020-06-30 |
| 32598450 | Clinical decision-making related to COVID-19 should focus away from chronological aging onto more a comprehensive geriatric care approach. | 2020-06-30 |
| 32598480 | COVID-19 related symptoms or complications following the procedures were not observed in any of the patients nor the healthcare care personnel. […] In this cohort of 300 electives cases, we found no patients with COVID-19 related symptoms postoperatively. | 2020-06-30 |
| 32598557 | The clinical characteristics, laboratory findings and chest computed tomography scans of all patients were recorded in detail. | 2020-06-30 |
| 32598830 | Hospitals in New York State reported cases of Kawasaki’s disease, toxic shock syndrome, myocarditis, and potential MIS-C in hospitalized patients younger than 21 years of age and sent medical records to the NYSDOH. […] We carried out descriptive analyses that summarized the clinical presentation, complications, and outcomes of patients who met the NYSDOH case definition for MIS-C between March 1 and May 10, 2020. […] Of 95 patients with confirmed MIS-C (laboratory-confirmed acute or recent severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] infection) and 4 with suspected MIS-C (met clinical and epidemiologic criteria), 53 (54%) were male; 31 of 78 (40%) were black, and 31 of 85 (36%) were Hispanic. […] All presented with subjective fever or chills; 97% had tachycardia, 80% had gastrointestinal symptoms, 60% had rash, 56% had conjunctival injection, and 27% had mucosal changes. | 2020-06-30 |
| 32598831 | Understanding the epidemiology and clinical course of multisystem inflammatory syndrome in children (MIS-C) and its temporal association with coronavirus disease 2019 (Covid-19) is important, given the clinical and public health implications of the syndrome. | 2020-06-30 |
| 32598884 | Two respiratory-associated fungal pathogens, A. flavus and Aspergillus niger, were detected in fecal samples from a subset of patients with COVID-19, even after clearance of SARS-CoV-2 from nasopharyngeal samples and resolution of respiratory symptoms. | 2020-06-30 |
| 32598911 | Providers must work with patients to balance competing risks of coronavirus disease 2019 and cancer, recognizing that communication is a critical clinical tool to improve quality of life in these times. | 2020-06-30 |
| 32598953 | This article reviewed the clinical use, mechanism and efficacy of the clinically approved drugs recommended in the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (DTPNCP) released by National Health Commission of P.R.China, and the novel therapeutic agents now undergoing clinical trials approved by China National Medical Products Administration (NMPA) to evaluate experimental treatment for COVID-19. | 2020-06-30 |
| 32599060 | Because CR is a class I level A recommendation with clinical benefits that are now well documented, the cessation of CR programs can lead to dramatic consequences in terms of public health. […] We propose here a viewpoint of significant interest about the sudden need to develop remote home-based CR programs both in clinical research and in clinical care routine. […] This last decade, the literature on remote home-based CR programs has been increasing, but to date only clinical research experiences have been implemented. | 2020-06-30 |
| 32599095 | However, a critical gap exists between the fast pace of biomarker discovery and the successful translation to clinical use. […] The unmet need for biomarkers in acute respiratory distress syndrome (ARDS) is for reliable and validated biomarkers that minimize heterogeneity and allow for stratification of subject selection for enrollment in clinical trials of tailored therapies. […] Accordingly, this review discusses the current state of ARDS biomarkers in the context of the drug development pipeline and highlight gaps between biomarker discovery and clinical implementation while proposing potential paths forward. […] We conclude by discussing challenges to successful translation of biomarker candidates to clinical impact and proposing possible novel strategies. | 2020-06-30 |
| 32599101 | At a Singaporean tertiary hospital, individuals with clinical syndromes compatible with COVID-19 but no epidemiologic risk were placed in cohorted general wards for COVID-19 testing. | 2020-06-30 |
| 32599159 | To investigate the clinical and epidemiological characteristics of paediatric patients with coronavirus disease-19 (COVID-19). […] Most of these patients had mild symptoms: mainly fever (20/32) followed by cough (10/32) and fatigue (4/32). | 2020-06-30 |
| 32599178 | Myocarditis from other viral pathogens can evolve into overt or subclinical myocardial dysfunction, and sudden death has been described in the convalescent phase of viral myocarditis. […] Some patients will have subclinical and possibly overt cardiovascular abnormalities. […] Therefore, now is the time to plan for appropriate registries and clinical trials to properly assess these issues and prepare for long-term sequelae of “post-COVID-19 cardiac syndrome.” | 2020-06-30 |
| 32599184 | In total, 13 themes from 18 studies were identified, grouped into 3 overriding themes: logistics, human resources, and clinical delivery. | 2020-06-30 |
| 32599304 | For patients in general, the clinical features resulting from respiratory syndromes can trigger an asymptomatic condition. […] Pregnant women are an unknown field in this complex process, and although they have symptoms similar to non-pregnant women, some points should be considered, such as complications during pregnancy and postpartum. […] Meanwhile, SARS-CoV and SARS-CoV-2 appear to have less severe symptoms. […] Thus, the limited reported obstetric cases alert to the need for advanced life support for pregnant women infected with coronaviruses and to the need for further investigation for application in clinical practice. | 2020-06-30 |
| 32599338 | This virus causes respiratory disease (for instance, flu) with symptoms such as cough, fever and, in severe cases, pneumonia. | 2020-06-30 |
| 32599589 | While most individuals remain asymptomatic or develop only mild symptoms, approximately 5% develop severe forms of COVID-19 characterized by acute respiratory distress syndrome (ARDS) and multiple-organ failure (MOF) that usually require intensive-care support and often yield a poor prognosis. […] The exaggerated cytokine release in response to viral infection, a condition known as cytokine release syndrome (CRS) or cytokine storm, is emerging as the mechanism leading to ARDS and MOF in COVID-19, thus endorsing the hypothesis that properly timed anti-inflammatory therapeutic strategies could improve patients’ clinical outcomes and prognosis. | 2020-06-30 |
| 32599601 | Gastrointestinal (GI) symptoms are increasingly being recognized in coronavirus disease 2019 (COVID-19). […] It is unclear if the presence of GI symptoms is associated with poor outcomes in COVID-19. […] We aim to assess if GI symptoms could be used for prognostication in hospitalized patients with COVID-19. […] The patients’ medical charts were reviewed for the presence of GI symptoms at admission, including nausea, vomiting, diarrhea, and abdominal pain. […] COVID-19 patients with GI symptoms (cases) were compared with COVID-19 patients without GI symptoms (control). […] A total of 150 hospitalized COVID-19 patients were included, of which 31 (20.6%) patients had at least 1 or more of the GI symptoms (cases). […] They were compared with the 119 COVID-19 patients without GI symptoms (controls). | 2020-06-30 |
| 32599633 | At the same time, symptoms occurred in all four family members. […] Symptoms were present for almost two weeks. […] All family members had anosmia, that started earlier and lasted longer than the other symptoms, and myalgia. […] Shortness of breath at rest or gastrointestinal symptoms were absent. […] The symptoms and course are described in detail. […] Anosmia can precede other symptoms by several days and can indicate an early phase of infection. […] The symptoms and course are discussed in the context of the ongoing pandemic, and efforts to control infection chains. | 2020-06-30 |
| 32599813 | This clinical reality creates an urgency for new antifungal drugs currently in advanced clinical development with more promising pharmacokinetic and pharmacodynamic profiles. | 2020-07-01 |
| 32599963 | Additionally, a recent retrospective clinical report showed that the treatment with famotidine provided a good outcome in patients infected with SARS-CoV2. […] A clinical trial testing effectiveness of famotidine in combination with hydroxychloroquine is currently ongoing in the United States (US). | 2020-07-01 |
| 32599972 | Pneumonia is the most serious clinical presentation of COVID-19. […] This study is aimed to determine the demographic, clinical, and laboratory findings that can properly predict COVID-19 pneumonia. | 2020-07-01 |
| 32600002 | Multimodal therapy is required for patients with severe symptoms. | 2020-07-01 |
| 32600101 | These procedures bear significant risk to the provider and clinical environment due to the possibility of viral aerosolization. […] While significant attention has been appropriately paid to personal protective equipment during this pandemic, an understanding of industrial hygiene is also necessary for the safe delivery of health care to mitigate the risk of exposure to other patients and health care workers. | 2020-07-01 |
| 32600165 | Methods: Clinical manifestations, laboratory results, and chest computed tomography scans were retrospectively reviewed for 50 patients with laboratory-confirmed COVID-19 without a history of thyroid disease who underwent thyroid function testing during their course of COVID-19 infection and after recovery. | 2020-07-01 |
| 32600175 | We analyzed the clinical course of OD and GD in a cohort of home-quarantined SARS-CoV-2-positive patients from Northern Italy. […] During follow-up, patients responded to online dedicated surveys modulated according to symptoms at T0. […] Three (2%) patients previously reporting complete resolution of symptoms complained of subsequent recurrence of OD and/or GD after a mean of 19 days from resolution of the previous episode. […] COVID-19-related OD and GD had high rate of resolution in the first month from onset of symptoms. […] However, in 10% to 15% of patients, these symptoms showed only partial improvement after this period. | 2020-07-01 |
| 32600183 | Prioritizing trainee protection and education as well as high-quality treatment for patients, the authors discuss effective communication strategies, rapid telepsychiatry expansion into clinical practice, curricular adjustments, and the importance of well-being. | 2020-07-01 |
| 32600363 | Healthy volunteers (18-60 years old) are treated in the Clinical Pharmacological Trial Center of Heidelberg University Hospital, Germany. […] EudraCT Number: 2020-001470-30 , registered on 31 March 2020 German Clinical trials register number / International Clinical Trials Registry Platform: DRKS00021573, registered on 27 April 2020 FULL PROTOCOL: The full trial protocol is attached as an additional file, accessible from the Trials website (Additional file 1). […] The trial protocol has been reported in accordance with the Standard Protocol Items: Recommendations for Clinical Interventional Trials (SPIRIT) guidelines (Additional file 2). | 2020-07-01 |
| 32600378 | Brazilian Clinical Trial Registry RBR-6m69fc . | 2020-07-01 |
| 32600411 | However, it is currently unknown if obesity plays a role in the clinical manifestations and prognosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. […] In this study, we aimed to investigate whether obesity played a role in clinical manifestations and prognosis in patients infected with SARS-CoV-2. […] This is a retrospective multicenter clinical study. […] Demographic and clinical data were extracted from medical records. […] The mean BMI was 22.35 ± 3.56 in patients experienced with relieving the clinical symptoms or stable condition by radiographic tests, lower than patients with disease exacerbation with 24.89 ± 3.17 (P = 0.001). […] Our study found BMI was significantly associated with clinical manifestations and prognosis of patients with SARS-CoV-2 infection. | 2020-07-01 |
| 32600426 | Around USD 0.49 billion were expected for clinical manage of COVID-19 in China. […] Our data demonstrate that clinical management of COVID-19 patients incurs a great financial burden to national health insurance. | 2020-07-01 |
| 32600460 | Participants were asked about the effect that the COVID-19 global pandemic had on final year medical written exams, electives, assistantships and objective structured clinical examinations (OSCEs). | 2020-07-01 |
| 32600484 | A scoring system was developed to predict the clinical outcome of these patients. | 2020-07-01 |
| 32600742 | TEE provides acute care clinicians with a goal-directed framework to guide clinical care and represents an ideal modality to evaluate hemodynamic instability during prone ventilation, perform serial evaluations of the lungs, support cardiac arrest resuscitation, and guide veno-venous ECMO cannulation. […] In the right clinical scenario, TEE is a tool that can provide the information needed to deliver the best and safest possible care for the critically ill patients. | 2020-07-01 |
| 32600777 | Vaccine solutions rarely reach the public until after an outbreak abates; an Ebola vaccine was approved 5 years after peak outbreak and SARS, MERS, and Zika vaccines are still in clinical development. | 2020-07-01 |
| 32600872 | The purpose of the present cross-sectional study was to investigate the relationship between the change in levels of perceived psychological stress and vocal symptoms among Israeli academic college professors required to shift to synchronous online teaching during the global COVID-19 pandemic. […] Participants provided self-reports for the current levels of psychological stress and vocal symptoms during the transition to online synchronous teaching, as well as general psychological stress and general vocal symptoms during previous periods of teaching. […] The results revealed higher levels of psychological stress but not vocal symptoms during the transition to online synchronous teaching compared with previous periods of teaching. […] Psychological stress during the transition to online synchronous teaching was positively associated with vocal symptoms during this period but this association was moderated by general stress. […] Although there was a positive association between psychological stress and vocal symptoms for individuals who reported low levels of psychological stress during previous periods of teaching, this association was especially strong for individuals who reported high levels of psychological stress during previous periods of teaching. […] It is important to examine vocal symptoms of professors in specific contexts that are potentially stressful. […] The psychological stress surrounding the transition to online synchronous teaching was associated with elevated levels of vocal symptoms especially for those who reported high levels of psychological stress during previous periods of teaching. | 2020-07-01 |
| 32600873 | To explore the prevalence of dysphonia in European patients with mild-to-moderate COVID-19 and the clinical features of dysphonic patients. […] The clinical and epidemiological data of 702 patients with mild-to-moderate COVID-19 were collected from 19 European Hospitals. […] The following data were extracted: age, sex, ethnicity, tobacco consumption, comorbidities, general, and otolaryngological symptoms. […] Dysphonia and otolaryngological symptoms were self-assessed through a 4-point scale. […] The prevalence of dysphonia, as part of the COVID-19 symptoms, was assessed. […] The prevalence of the following symptoms was higher in dysphonic patients compared with nondysphonic patients: cough, chest pain, sticky sputum, arthralgia, diarrhea, headache, fatigue, nausea, and vomiting. […] Future studies are needed to investigate the relevance of dysphonia in the COVID-19 clinical presentation. | 2020-07-01 |
| 32600991 | The aim of this study was to evaluate the clinical implications of previous treatment with ACEI/ARB on the prognosis of patients with COVID-19 infection. | 2020-07-01 |
| 32601006 | The clinical therapy for severe 2019 coronavirus disease (i.e., COVID-19) sufferers is relatively challenging. […] According to her symptoms and examination reports, endotracheal intubation and mechanical ventilation were timely conducted and meanwhile high-dose sedatives and analgesics were administrated. | 2020-07-01 |
| 32601020 | The symptoms of the disease range from asymptomatic to mild respiratory symptoms and even potentially life-threatening cardiovascular and pulmonary complications. | 2020-07-01 |
| 32601022 | The position statement complements, and should be read in conjunction with, the National Heart Foundation of Australia & Cardiac Society of Australia and New Zealand: Australian Clinical Guidelines for the Management of Acute Coronary Syndromes 2016: Section 2 ‘Assessment of Possible Cardiac Chest Pain’. | 2020-07-01 |
| 32601577 | The COVID-19 preferentially damages the respiratory system that produces symptoms such as fever, cough, and shortness of breath. […] Recent evidence indicates that SARS-CoV-2 can cause significant neurological damage and resultant neurological symptoms and complications. […] Headache and dizziness were found to be the most prevalent symptoms followed by impaired consciousness. […] Among the symptoms indicating peripheral nervous system invasion, anosmia and dysgeusia were commonly reported. […] The aim of this review is to provide a deeper understanding of the potential neurological implications to help neurologists have a high index of clinical suspicion allowing them to manage the patient appropriately. | 2020-07-01 |
| 32601623 | The battle against cancer is formidable even in normal circumstances and the COVID-19 selectively cancer patients with an increased risk of mortality by three times higher than those without cancer but also forced us to shut down the clinical trials in cancer patients to deal with the present crisis. | 2020-07-01 |
| 32601708 | The definition, prevention, and treatment of symptoms of CRS in critically ill patients with COVID-19 are important problems. | 2020-07-01 |
| 32602128 | Dynamic changes of immunocyte subsets and inflammatory profiles in coronavirus disease 2019 (COVID-19) patients with gastrointestinal symptoms were undetermined. […] The relations of diarrhea and immuno-inflammatory factors with illness course and clinical outcomes were further explored. | 2020-07-01 |
| 32602202 | Epidemiological, clinical, and laboratory characteristics and treatment data were collected. | 2020-07-01 |
| 32602262 | To report the clinical experience with anakinra for preventing mechanical ventilation (MV) in patients with COVID-19, features of cytokine storm syndrome (CSS), and acute hypoxic respiratory failure (AHRF). […] Our patient selection and treatment approach should be considered for investigation in a clinical trial to determine the safety and efficacy of anakinra in patients with COVID-19 and features of CSS. | 2020-07-01 |
| 32602272 | To determine the role of diabetes mellitus (DM) in the coronavirus disease 2019 (COVID-19), we explored the clinical characteristics of patients with DM and compared risk factors such as age, glycemic control, and medications to those without DM. […] We analyzed what clinical features and glycemic control-related factors affect the prognosis of COVID-19 in the DM group. […] Intensive and aggressive monitoring of COVID-19 clinical outcomes in DM group, especially in elderly patients is warranted. | 2020-07-01 |
| 32602404 | Our New York consortia and organ procurement organizations met online 3 times a week and shared creative strategies to address clinical care and work processes. | 2020-07-01 |
| 32602604 | Although it has been reported that some COVID-19 patients showed elevated liver biochemistries, there are few studies regarding clinical features and prognosis of these patients. […] The data on demographics, comorbidities, clinical symptoms, laboratory examinations on admission, complications, treatment, and outcome were collected. | 2020-07-01 |
| 32602675 | We aim to identify the defining clinical and radiological characteristics, severity and prognosis, along with impact of age on outcome. […] We observed male predominance, mean age of 36 years, with less or no symptoms, majority brought in after screening and contact tracing by the screening teams. […] Radiographic abnormality was frequently associated irrespective of clinical presentation and its severity. […] Clinical and laboratory findings are similar to those found in viral diseases. | 2020-07-01 |
| 32602676 | We aim to find out the rate of SARS-CoV-2 positivity in SARI cases and further clarify the epidemiological and clinical characteristics of NCIP in New Delhi, India. […] To find out the rate of SARS-CoV-2 positivity in SARI cases presenting to the hospital emergency and describe the epidemiological and clinical characteristics of NCIP. […] Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. […] Common symptoms included dyspnea 29(90.6%) followed by cough 27(84.4%), fever 22(68%), bodyache and myalgias 14(43.75%). | 2020-07-01 |
| 32602677 | Data on flu-like symptoms, travel history, posting in high-risk or low risk zones, and prophylactic drugs was collected. […] 14.7% had flu-like symptoms. […] HCWs posted in the high-risk zones had more symptoms than those working in low-risk zones (169/539, 31.4% vs 679/3128, 21.7%), p<0.001; but no difference in COVID-19 positivity rates (p=0.849). | 2020-07-01 |
| 32602678 | The objective of this work is to report the initial experience with demographic and clinical features, and management of COVID-19 patients admitted in medical college Bhilwara, India. […] Demographical, clinical, laboratory, and radiological characteristics and treatment and outcomes data were obtained with data collection forms and history given by 26 COVID-19 patients. | 2020-07-01 |
| 32602679 | The present study was undertaken to investigate and quantify the severity of COVID-19 infection on high-resolution chest computed tomography (CT) and to determine its relationship with clinical parameters. […] This study also aimed to see CT changes with clinical recovery or progression of disease. […] In an attempt to provide extensive information pertaining to clinical and radiological characteristics of COVID-19, the present study was undertaken in 80 hospitalized patients. […] Initially all patients were evaluated for their clinical parameters and then correlated with HRCT chest after hospitalization. […] Out of total analyzed patients, 39 patients (48.75%) were symptomatic, among them fever (79.47%), cough (74.35%), shortness of breath (36%) and sore throat (17.94%) were the most common presenting clinical manifestations. […] A few patients (12.82%) also had other symptoms like headache, chest pain, pain abdomen, altered sensorium etc. 54% patients had some underlying co morbid disease in sample population. […] The clinical status of patients correlated with the CT severity score, with mild cases showing score <15/25 in 45.83% patients and severe cases showing CT severity score >15/25 in 87.50% patients. […] Clinical symptoms of patients directly correlated with CT severity index. […] CT imaging was found to be useful in predicting clinical recovery of patients or progression of disease. | 2020-07-01 |
| 32602812 | This can help to speed up the research and implementation of telerehabilitation in daily clinical practice. | 2020-07-01 |
| 32602884 | Biomedical Informatics was integral to our institutional response in supporting clinical care through new and reconfigured technologies. | 2020-07-01 |
| 32603180 | Nutritional status appears to be a relevant factor influencing the clinical outcome of critically ill patients with COVID-19. […] The purpose of this review is to analyze the main recommendations related to adequate nutritional management for critically ill patients with COVID-19 in order to improve their prognosis and clinical outcomes. | 2020-07-01 |
| 32603424 | ACE2 is expressed in pancreatic islets, vascular endothelium, and adipose tissue, and the SARS-CoV-2 -ACE2 interaction in these tissues, along with other factors, governs the spectrum and the severity of clinical manifestations among COVID-19 patients with metabolic syndrome. […] This review describes the spectrum of clinical features, the likely pathophysiologic mechanisms, and potential implications for the management of metabolic syndrome in COVID-19 patients. | 2020-07-01 |
| 32603515 | This study investigates the clinical and imaging characteristics of coronavirus disease 2019 (COVID-19) patients with false-negative nucleic acids. […] Their epidemiological, clinical, and laboratory examination data and imaging characteristics were analyzed. […] The false-negative cases of COVID-19 are worth noting because they have a risk of viral transmission without positive test results, lighter clinical manifestations, and less history of epidemiological exposure. | 2020-07-01 |
| 32603531 | The aim of this clinical trial was to evaluate the effects of febuxostat (FBX) in comparison with hydroxychloroquine (HCQ) on clinical symptoms, laboratory tests and chest CT findings in outpatients with moderate symptoms of COVID-19 infection. […] We conducted a clinical trial involving adult outpatients with the moderate respiratory illness following COVID-19 infection. […] The measured variables were needs to hospitalisation, clinical and laboratory data including fever, cough, breathing rate, C-Reactive Protein level, lymphocytes count at onset of admission and was well as at 5 days of treatments. […] In adult outpatients with moderate COVID-19 infection, the effectiveness of FBX and HCQ was not different in terms of resolution of clinical manifestations, laboratory tests and lung CT findings. | 2020-07-01 |
| 32603679 | In severe disease, there is hyperinflammation causing severe symptoms. | 2020-07-01 |
| 32603692 | Nevertheless, at the same time, the high quantity of clinical data, generated by a large number of rapidly infected people, require accurate tests regarding effective medical treatments. […] Initial clinical studies revealed the promising potential of remdesivir that demonstrated a powerful and specific in vitro antiviral activity for COVID-19. […] However, few data from ongoing clinical trials are identifying low molecular weight heparins, innate immune system stimulating agents, and inflammatory modulating agents as potential effective agents. […] This work is aimed to be a general reference point and to provide an overview as comprehensive as possible regarding the main clinical trials in progress at the moment. | 2020-07-01 |
| 32603770 | In this paper, we systematically reviewed the available imaging findings of patients diagnosed with neurological symptoms associated with coronavirus infections. | 2020-07-01 |
| 32603793 | Application scenarios are several, and they spread from simple clinical assisting scenarios to an emergency one. | 2020-07-01 |
| 32603802 | Although clinical observational studies reported the improvement in symptoms and oxygenation for individuals with severe COVID-19 who received corticosteroid therapy, case fatality rate in the corticosteroid group was significantly higher than that in the non-corticosteroid group (69/443, 15.6% versus 56/1310, 4.3%). […] Although there is no evidence that corticosteroid therapy reduces mortality in people with COVID-19, some improvements in clinical symptoms and oxygenation were reported in some clinical observational studies. | 2020-07-01 |
| 32603803 | Patient demographics, microbiology and clinical outcomes were analysed. | 2020-07-01 |
| 32603829 | Both SARS and COVID-19 share similar symptoms such as fever, cough, and difficulty in breathing that can become fatal in later stages. | 2020-07-01 |
| 32603887 | The identified articles, journal papers and preprints, mostly covered the epidemiology of COVID-19 (35.7 %), clinical aspects of infection (21.0 %), preventative measures (12.8 %), treatment options (12.5 %), diagnostics (12.2 %), mathematical modeling of disease transmission and mitigation (9.6 %), and molecular biology and pathogenesis of SARS-CoV-2 (8.7 %). | 2020-07-01 |
| 32603901 | To assess the frequency of asthma exacerbation in patients with asthma hospitalized for SARS-CoV-2 pneumonia and compare symptoms and laboratory and radiological findings in patients with and without asthma with SARS-CoV-2 pneumonia. […] To assess the patients’ asthma status, 3 periods were defined: the last month before the onset of COVID-19 symptoms (p1), prehospitalization (p2), and during hospitalization (p3). | 2020-07-01 |
| 32603930 | Psychotic symptoms have been related to other coronavirus infections. […] Ten patients infected by the novel coronavirus with psychotic symptoms and no previous history of psychosis were identified by the emergency and liaison psychiatry departments. […] Nine of the cases presented with psychotic symptoms at least two weeks after the first somatic manifestations attributed to COVID-19 and receiving pharmacological treatment. […] Structured delusions mixed with confusional features were the most frequent clinical presentations. […] Hence, COVID-19 patients can develop psychotic symptoms as a consequence of multiple concurrent factors. | 2020-07-01 |
| 32604011 | Thus far it appears that with the current strains of these two viruses, the clinical outcome of co-infection is not significantly worse than infection with COVID-19 alone. | 2020-07-01 |
| 32604013 | Baseline demographic and clinical data from 100 apparently non-diabetic household members (related or unrelated) of patients with type 2 diabetes mellitus were collected until 49 days of lockdown and analyzed using the XL-STAT statistical software. | 2020-07-01 |
| 32604085 | Computed tomography (CT) of the chest can verify infection in patients with clinical symptoms and a negative test result, accelerating treatment and actions to prevent further contagion. | 2020-07-01 |
| 32604138 | There are few studies, however, on the demographics, comorbidities, clinical presentation, or outcomes of COVID-19 in people with HIV. […] To evaluate risk factors, clinical manifestations, and outcomes in a large cohort of PLWH with COVID-19. […] We analyzed each of the cases to extract information including demographics, medical comorbidities, clinical presentation, and illness course after COVID-19 diagnosis. | 2020-07-01 |
| 32604203 | Upset patients reported a greater impact of PFD symptoms on their mood than those who were not upset (P=0.002). | 2020-07-01 |
| 32604223 | Its clinical presentation can vary from the asymptomatic state to acute respiratory distress syndrome (ARDS) and multi-organ dysfunction. | 2020-07-01 |
| 32604322 | These guidelines are not meant to replace sound clinical judgment or specialist consultation but rather to strengthen provision and clinical management of ECMO specifically, in the context of the COVID-19 pandemic. | 2020-07-01 |
| 32604404 | Here we collected information on the demography, clinical presentation, hospitalization, contact network and the presence of SARS-CoV-2 infection in nasopharyngeal swabs for 85.9% and 71.5% of the population of Vo’ at two consecutive time points. […] Notably, 42.5% (95% CI: 31.5-54.6%) of the confirmed SARS-CoV-2 infections detected across the two surveys were asymptomatic (that is, did not have symptoms at the time of swab testing and did not develop symptoms afterwards). | 2020-07-01 |
| 32604407 | Effective initial host defense in the lung is associated with mild symptoms and disease resolution. | 2020-07-01 |
| 32604593 | The aim of our study is to propose a remote patient monitoring solution through a smart phone application (Smart Patient) collecting health data to support diagnosis, monitoring and predicting poor outcome in asymptomatic/mild cases of COVID-19, including signs and symptoms, risk factors, comorbidities, medications and vital signs such as body temperature, respiratory rate, heart rate and oxygen saturation. […] By continuous daily recording of suspected cases and patients, family doctors in the community will be able to follow up cases and intervene promptly when deterioration in vital signs and symptoms takes place referring the patient to the hospital. | 2020-07-02 |
| 32604775 | As the COVID-19 pandemic has approached its culmination, desperate efforts have been made to seek proper treatments and response strategies, and the number of clinical trials has been rapidly increasing. […] Thus, this study aims at providing a comprehensive landscape of COVID-19 related clinical trials based on the ClinicalTrials.gov database. […] Materials and methods: Up to 30 March 2020, we identified a total of 147 eligible clinical trials and reviewed the overview of the studies. […] Results: Until then, the most clinical trials were set up in China. […] Conclusions: In this study, we introduced the promising therapeutic options that many researchers and clinicians are interested in, and to address the hidden issues behind clinical trials in this COVID-19 pandemic. | 2020-07-02 |
| 32604825 | The present review aims to summarize the structure, epidemiology, symptoms, statistical status of the disease status, intervention strategies and deliberates the lessons learnt during the pandemic. | 2020-07-02 |
| 32604895 | We aimed to report the clinical and psychological impact of COVID-19 infection in EGID patients. […] Data regarding the occurrence and perception of COVID-19 infection as well as clinical information were recorded. […] Female gender and low education level were associated to a higher psychological perception of COVID-19 compared to lockdown status or other demographic and clinical factors (p < 0.05). […] Overall, COVID-19 had a limited clinical impact on patients with EGIDs. | 2020-07-02 |
| 32604906 | Precautionary measures should be applied to control COVID-19 in clinical practice. | 2020-07-02 |
| 32604919 | Validated and accurate laboratory testing for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a crucial part of the timely management of Coronavirus Disease 2019 (COVID-19) disease, supporting the clinical decision-making process for infection control at the healthcare level and detecting asymptomatic cases. […] Due to the current pandemic situation, a development of point-of-care diagnostics (POCD) allows us to substantially accelerate taking clinical decisions and implement strategic planning at the national level of preventative measures. | 2020-07-02 |
| 32605097 | The ones most applied by citizens were to avoid non-mandatory transportation, contact with individuals with respiratory symptoms, and individuals of high risk for severe illness (vulnerable groups). | 2020-07-02 |
| 32605192 | Consequently, the scientific community is working hard to gain useful information about the history of this virus, its transmission, diagnosis, clinical features, radiological findings, research and development of candidate therapeutics as well as vaccines. […] In light of this scenario, in this review, we suggest a flow chart for the pathologist called on to ascertain the cause of death of a subject with historical and clinical findings of COVID-19 status or without any anamnestic, diagnostic, or exposure information. | 2020-07-02 |
| 32605194 | Women and children are less susceptible to SARS-CoV-2 infection, while the elderly and people with comorbidities are more prone to serious clinical outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. […] Similarly, vaccines and therapeutics against COVID-19 are currently in the pipeline for clinical trials. | 2020-07-02 |
| 32605250 | The COVID-19-SES is a psychometrically robust instrument that allows for a valid and reliable assessment of people’s self-efficacy in preventing, detecting symptoms, and home-managing COVID-19. | 2020-07-02 |
| 32605278 | This may imply novel therapies in clinical development (e.g., the Fas ligand trap asunercept), but uptake of repurposed drugs already in clinical use may be faster. […] Further, preclinical data support a beneficial effect for the lung. […] We now discuss the potential benefits and risks of SGLT2 inhibitors in COVID-19 and an ongoing clinical trial testing the impact of dapagliflozin on outcomes in COVID-19 patients with respiratory failure. | 2020-07-02 |
| 32605363 | However, on the basis of previously reported results from SARS-CoV-1, antigen-based SARS-CoV-2 assays may have significantly better clinical sensitivity than serology assays. | 2020-07-02 |
| 32605549 | Scientific studies to date have focused primarily on describing the clinical course of patients, identifying treatment options and developing vaccines. […] For twelve months, each household member is asked to keep a diary of daily symptoms, whereabouts and contacts via WebApp. […] If symptoms suggestive for COVID-19 are reported, family members, including children < 14 years, are offered a pharyngeal swab taken at the Division of Infectious Diseases and Tropical Medicine, LMU University Hospital Munich, for molecular testing for SARS-CoV-2. […] In case of severe symptoms, participants will be transferred to a Munich hospital. | 2020-07-02 |
| 32605661 | One reason is that the challenges underneath sequencing SARS-CoV-2 directly from clinical samples have not been completely tackled, i.e., sequencing samples with low viral load often results in insufficient viral reads for analyses. […] We applied a novel multiplex PCR amplicon (amplicon)-based and hybrid capture (capture)-based sequencing, as well as ultra-high-throughput metatranscriptomic (meta) sequencing in retrieving complete genomes, inter-individual and intra-individual variations of SARS-CoV-2 from serials dilutions of a cultured isolate, and eight clinical samples covering a range of sample types and viral loads. […] We demonstrated that both amplicon and capture methods efficiently enriched SARS-CoV-2 content from clinical samples, while the enrichment efficiency of amplicon outran that of capture in more challenging samples. […] We illustrated that meta uncovered rich genetic information in the clinical samples besides SARS-CoV-2, providing references for clinical diagnostics and therapeutics. | 2020-07-02 |
| 32605665 | Supplying reusable respirators to individual staff members may increase the likelihood of them having appropriate personal protective equipment during their clinical duties. | 2020-07-02 |
| 32605666 | Chemosensitive disorders have been confirmed to be frequent and early symptoms of the coronavirus infection, and, in a significant number of cases, they are the first or only manifestation of coronavirus disease 2019. | 2020-07-02 |
| 32605683 | These findings may provide insight into disease severity and treatment options in the rural setting with limited resources to participate in clinical trials and encourage larger comparative studies evaluating treatment efficacy. | 2020-07-02 |
| 32605788 | The service was compared to the existing ACS service in terms of clinical and efficiency outcomes. | 2020-07-02 |
| 32605826 | It causes Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and presents a broad spectrum of clinical manifestations, ranging from entirely asymptomatic through severe acute respiratory failure and death. | 2020-07-02 |
| 32605933 | The COVID-19 pandemic forces sport and exercise medicine (SEM) physicians to think differently about the clinical care of patients. […] It is crucial for SEM physicians, technology providers and organisations to codesign teleSEM services, ideally involving athletes, coaches and other clinicians involved in the clinical care of athletes, and to gradually implement these services with appropriate support and education. teleSEM provides solutions for remote athlete clinical care during and after the COVID-19 pandemic. | 2020-07-02 |
| 32606051 | However, several early studies support the potential role of this practice to improve oxygenation, improve clinical outcomes, and reduce the need for intensive care admission. | 2020-07-02 |
| 32606103 | A survey-based study focused on randomized controlled trials (RCTs) and single-arm studies for acute ischemic stroke and cerebral aneurysms was developed by a group of senior neurointerventionalists and sent to sites identified through the clinical trials website (https://clinicaltrials.gov/), study sponsors, and physician investigators. […] As sites resume clinical research, steps to mitigate similar challenges in the future should be considered. | 2020-07-02 |
| 32606105 | The initial respiratory pathogen panel was positive for adenovirus, consistent with his symptoms. | 2020-07-02 |
| 32606285 | Troponin was mildly elevated without any anginal symptoms. | 2020-07-02 |
| 32606509 | Two patients with ICH were SARS-CoV-2 positive and they had no or mild respiratory symptoms and had higher occurrence of renal dysfunction. | 2020-07-02 |
| 32606886 | Many people are asymptomatic or with mild symptoms. | 2020-07-02 |
| 32607242 | A likely contributing factor was the lack of symptoms of some of the carriers, making them unaware of their risk of spreading to other more vulnerable individuals. […] The other important finding has been the reported cases of infectivity despite lack of symptoms. | 2020-07-02 |
| 32607304 | A real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay confirmed a diagnosis of COVID-19 infection, resulting in the patient’s admission to the airborne isolation unit for clinical observation. | 2020-07-02 |
| 32607310 | With the increasing number of confirmed cases and accumulating clinical data, our understanding of COVID-19 continues to evolve. | 2020-07-02 |
| 32607332 | Therefore, it is highly essential to analyze the epidemiological and clinical characteristics of COVID-19 in areas outside Wuhan or Hubei Province. […] To date, a limited number of studies have concentrated on the epidemiological and clinical characteristics of COVID-19 patients with different genders, clinical classification, and with or without basic diseases. […] To study the epidemiological and clinical characteristics of COVID-19 patients in Hengyang (China) and provide a reliable reference for the prevention and control of COVID-19. […] The diagnostic criteria, clinical classification, and discharge standard related to COVID-19 were in line with the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 7) released by National Health Commission and National Administration of Traditional Chinese Medicine. […] The mean time from onset of symptoms to the first physician visit was 3.38 ± 2.98 (95%CI: 2.58-9.18) d, with a median of 2 (IQR: 1-5) d, and the mean time from hospital admission to confirmed diagnosis was 2.29 ± 2.11 (95%CI: 1.18-6.42) d, with a median of 2 (IQR: 1-3) d. […] The main symptoms were fever [43 (89.6%) of 48], cough and expectoration [41 (85.4%)], fatigue [22 (45.8%)], and chills [22 (45.8%)]. […] Other symptoms included poor appetite [13 (27.1%)], sore throat [9 (18.8%)], dyspnea [9 (18.8%)], diarrhea [7 (14.6%)], dizziness [5 (10.4%)], headache [5 (10.4%)], muscle pain [5 (10.4%)], nausea and vomiting [4 (8.3%)], hemoptysis [4 (8.3%)], and runny nose [1 (2.1%)]. | 2020-07-02 |
| 32607346 | We report 3 cases with low-grade fever during COVID-19 convalescence and highlight the main clinical, radiographic, and laboratory characteristics, thereby increasing the level of expertise in the clinical management of COVID-19 during convalescence and facilitating individualized decision-making. | 2020-07-02 |
| 32607393 | The present research aims to summarize the association in COVID-19 patients between molecular dimensions of comorbidities with clinical and preclinical information. […] All predicted biomarkers must be validated either through randomized clinical trials or experimental assays before clinical application in patients. | 2020-07-02 |
| 32607398 | Methylene blue (MB, oxidized form, blue color) has been used in many different areas of clinical medicine, ranging from malaria to orthopedics. | 2020-07-02 |
| 32607400 | The most common symptoms were weakness and fatigue. | 2020-07-02 |
| 32607420 | We also discuss clinical dilemmas in the management COVID-19 in the posttransplant recipient. | 2020-07-02 |
| 32607454 | Clinical and biological picture was suggestive of cytokine release syndrome. | 2020-07-02 |
| 32607467 | Therefore, the complex clinical picture of patients with severe complications of COVID-19 is triggered by the various effects of highly expressed angiotensin II on vasculopathy, coagulopathy, and inflammation. | 2020-07-02 |
| 32607499 | Coronavirus disease 2019 (COVID-19) causes a respiratory illness with symptoms such as dry cough, fever, sudden loss of smell, and, in more severe cases, difficulty breathing. […] We also summarize potential treatments and vaccines against COVID-19 and discuss ongoing clinical trials of interventions to reduce viral progression. | 2020-07-02 |
| 32607505 | While the global COVID-19 pandemic has challenged the entire humanity and health systems, it also triggered researchers to urgently perform clinical trials to assess the safety and efficacy of many agents and modalities to combat COVID-19. […] As of April 22, over 650 clinical studies have been registered both in USA and internationally. […] We searched the NCI website and Medline and summarize various national and international clinical trials and summarize few of the pivotal ones in this paper, including those specific to oncology population. […] It is essential to acknowledge the devotion and hard work of the clinical research team and clinical research volunteers. | 2020-07-02 |
| 32607633 | Demographic, hospitalization, clinical, and procedural data were obtained for both groups and statistically compared with univariable analysis. | 2020-07-02 |
| 32607634 | Clinical data and laboratory results were collected. […] • A predictive model and scoring system combining both clinical and CT features were herein developed to enable high diagnostic efficiency for COVID-19. | 2020-07-02 |
| 32607704 | Healthcare providers should encourage patients with suspected symptoms of STEMI to call for emergency care to ensure rapid diagnosis and timely reperfusion treatment. | 2020-07-02 |
| 32607737 | We developed two machine learning classification models using hematochemical values from routine blood exams (namely: white blood cells counts, and the platelets, CRP, AST, ALT, GGT, ALP, LDH plasma levels) drawn from 279 patients who, after being admitted to the San Raffaele Hospital (Milan, Italy) emergency-room with COVID-19 symptoms, were screened with the rRT-PCR test performed on respiratory tract specimens. […] This study demonstrated the feasibility and clinical soundness of using blood tests analysis and machine learning as an alternative to rRT-PCR for identifying COVID-19 positive patients. […] We made available a Web-based tool for clinical reference and evaluation (This tool is available at https://covid19-blood-ml.herokuapp.com/). | 2020-07-02 |
| 32607830 | After a joint on-site inspection of the dental clinic with the Department of Clinical Microbiology and Hospital Hygiene, existing clinical and hygiene protocols were adapted for COVID-19 patients. | 2020-07-02 |
| 32607866 | There is an urgent need for an ideal animal model that can reflect clinical symptoms and underlying etiopathogenesis similar to COVID-19 patients which can be further used for evaluation of underlying mechanisms, potential vaccines, and therapeutic strategies. | 2020-07-02 |
| 32607928 | To describe the clinical characteristics and risk factors associated with mortality in a large patient population in the USA. […] Retrospective cohort study. 6493 patients who had laboratory-confirmed COVID-19 with clinical outcomes between March 13 and April 17, 2020, who were seen in one of the 8 hospitals and/or over 400 ambulatory practices in the New York City metropolitan area MAIN MEASURES: Clinical characteristics and risk factors associated with in-hospital mortality. | 2020-07-02 |
| 32608131 | There was an increase of 19% and 15% in the mental health discussion and detection of symptoms in the iCCAS group compared with the usual care. | 2020-07-02 |
| 32608207 | At 31 days after the last event, all screening laboratory results were negative, and no symptoms/signs were reported. | 2020-07-02 |
| 32608250 | Also, students were concerned that learning of clinical material and professional training would be impaired, and they were afraid of failing the year of education. | 2020-07-02 |
| 32608325 | Moreover, contacts exposed to index case in symptomatic period (RR: 2.15, 95%CI: 1.67-2.79), with critically severe symptoms (RR: 1.61, 95%CI: 1.00-2.57), with symptoms of dizzy (RR: 1.58, 95%CI: 1.08-2.30), myalgia (RR: 1.49, 95%CI: 1.15-1.94), and chill (RR: 1.42, 95%CI: 1.05-1.92) had higher infected risks. | 2020-07-02 |
| 32608380 | In recent weeks, several reports have emerged of skin lesions with different clinical presentations in COVID-19 cases. […] All dermatologists should be aware of these cutaneous lesions, which may be early clinical symptoms of infection. […] The major clinical forms described were maculopapular eruptions, acral areas of erythema with vesicles or pustules (pseudochilblain), urticarial lesions, other vesicular eruptions and livedo or necrosis. […] The mean latency time in the majority of cases was between 1 and 14 days; however, in some patients, lesions appeared 2 to 5 days before the onset of COVID-19 symptoms. […] The histopathological features of these lesions also vary, corresponding to the diversity of clinical manifestations. | 2020-07-02 |
| 32608590 | The choice of the model as well as the choice of the assessment tool are discussed in the light of the clinical objectives pursued by health professionals. | 2020-07-02 |
| 32608926 | Most patients have mild symptoms without the need for hospitalization. […] On average, 5% of the COVID-19-positive patients have severe respiratory symptoms. […] We present 3 patients aged 45, 67 and 75 years, who were admitted to the ICU with severe respiratory symptoms. | 2020-07-02 |
| 32609102 | Others do not show any symptoms, but can still contribute to the transmission of the virus. | 2020-07-02 |
| 32609142 | to describe the most frequent signs and symptoms of infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). this is a narrative literature review carried out in April 2020; the search was performed on electronic databases and complemented with a manual review of the references of the selected papers and Brazilian Ministry of Health publications. the spectrum of clinical disease was wide; fever, coughing and dyspnea were the most frequent signs/symptoms, however, they may not be present, thus hindering case definition; gastrointestinal symptoms and loss of taste or smell have been reported among mild cases; dyspnea was frequent among severe and fatal cases. considering the scarcity of diagnostic tests and the diversity of symptoms, health services should use a sensitive case definition, in order to adopt appropriate surveillance, prevention and treatment actions. | 2020-07-02 |
| 32609144 | New perspectives regarding a change in face-to-face activities, social isolation and the reformulation of clinical activities result in a transition toward e-learning and e-teaching processes. | 2020-07-02 |
| 32609168 | The main questions by participants related to risk factors, transmission, immunity to the novel coronavirus, care related to prevention, symptoms, and treatment; and COVID-19 and influenza vaccine. | 2020-07-02 |
| 32609256 | The diagnosis of COVID-19 is based on the clinical and epidemiological history of the patient. | 2020-07-02 |
| 32609284 | Data were analyzed and synthesized in the form of a narrative. the final sample was composed of 24 records, the content of which was synthesized in these conceptual categories: clinical manifestations, diagnosis, treatment, working pregnant women, vaccine development, complications, prenatal care, vertical transmission, and placental transmissibility. | 2020-07-02 |
| 32609336 | In this case-series study, patients younger than 18 years who presented with SARS-CoV-2 infection and neurological symptoms to Great Ormond Street Hospital for Children (London, UK) between March 1, 2020, and May 8, 2020, were included after infection was confirmed by either a quantitative reverse transcription-polymerase chain reaction assay by nasopharyngeal swab or a positive test result for IgG antibodies against SARS-CoV-2 in serum. […] Clinical and paraclinical features were retrieved from electronic patient records. […] Of the 27 children with COVID-19 pediatric multisystem inflammatory syndrome, 4 patients (14.8%) who were previously healthy had new-onset neurological symptoms. […] Symptoms included encephalopathy, headaches, brainstem and cerebellar signs, muscle weakness, and reduced reflexes. […] In this case-series study, children with COVID-19 presented with new neurological symptoms involving both the central and peripheral nervous systems and splenial changes on imaging, in the absence of respiratory symptoms. […] Additional research is needed to assess the association of neurological symptoms with immune-mediated changes among children with COVID-19. | 2020-07-02 |
| 32609353 | People exposed to coronavirus disease 2019 (COVID-19) and a series of imperative containment measures could be psychologically stressed, yet the burden of and factors associated with mental health symptoms remain unclear. […] To investigate the prevalence of and risk factors associated with mental health symptoms in the general population in China during the COVID-19 pandemic. […] The prevalence of symptoms of depression, anxiety, insomnia, and acute stress among the general population in China during the COVID-19 pandemic was evaluated using the Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, Insomnia Severity Index, and Acute Stress Disorder Scale. […] During the COVID-19 pandemic, the rates of mental health symptoms among the survey respondents were 27.9% (95% CI, 27.5%-28.2%) for depression, 31.6% (95% CI, 31.2%-32.0%) for anxiety, 29.2% (95% CI, 28.8%-29.6%) for insomnia, and 24.4% (95% CI, 24.0%-24.7%) for acute stress. […] Participants with confirmed or suspected COVID-19 and their family members or friends had a high risk for symptoms of depression (adjusted odds ratios [ORs], 3.27 [95% CI, 1.84-5.80] for patients; 1.53 [95% CI, 1.26-1.85] for family or friends), anxiety (adjusted ORs, 2.48 [95% CI, 1.43-4.31] for patients; 1.53 [95% CI, 1.27-1.84] for family or friends), insomnia (adjusted ORs, 3.06 [95% CI, 1.73-5.43] for patients; 1.62 [95% CI, 1.35-1.96] for family or friends), and acute stress (adjusted ORs, 3.50 [95% CI, 2.02-6.07] for patients; 1.77 [95% CI, 1.46-2.15] for family or friends). […] Moreover, people with occupational exposure risks and residents in Hubei province had increased odds of symptoms of depression (adjusted ORs, 1.96 [95% CI, 1.77-2.17] for occupational exposure; 1.42 [95% CI, 1.19-1.68] for Hubei residence), anxiety (adjusted ORs, 1.93 [95% CI, 1.75-2.13] for occupational exposure; 1.54 [95% CI, 1.30-1.82] for Hubei residence), insomnia (adjusted ORs, 1.60 [95% CI, 1.45-1.77] for occupational exposure; 1.20 [95% CI, 1.01-1.42] for Hubei residence), and acute stress (adjusted ORs, 1.98 [95% CI, 1.79-2.20] for occupational exposure; 1.49 [95% CI, 1.25-1.79] for Hubei residence). […] The results of this survey indicate that mental health symptoms may have been common during the COVID-19 outbreak among the general population in China, especially among infected individuals, people with suspected infection, and people who might have contact with patients with COVID-19. | 2020-07-02 |
| 32609360 | Duration of persistence of SARS-CoV-2 in the upper respiratory tract of infected individuals has important clinical and epidemiological implications. | 2020-07-02 |
| 32609640 | Clinical specificity was evaluated by measuring 972 hospitalized patients and 586 donors of a normal population. […] Clinical sensitivity was assessed on 513 confirmed cases of SARS-CoV-2 by RT-PCR. […] SARS-CoV-2 IgM showed clinical specificity of 97.33 and 99.49% for hospitalized patients and the normal population respectively, and SARS-CoV-2 IgG showed clinical specificity of 97.43 and 99.15% respectively. […] SARS-CoV-2 IgM showed clinical sensitivity of 82.54, 92.93, and 84.62% before 7 days, 7-14 days, and after 14 days respectively, since onset of symptoms, and SARS-CoV-2 IgG showed clinical sensitivity of 80.95, 97.98, and 99.15% respectively at the same time points above. […] The assays demonstrated high clinical specificity and sensitivity, and add great value to nucleic acid testing in fighting against the global pandemic of the SARS-CoV-2 infection. | 2020-07-02 |
| 32609763 | Assess how people perceive the risks of coronavirus infection, whether people take preventive measures, and which pre-outbreak factors contribute to the perceived risks and measures taken, such as pre-outbreak respiratory problems, heart problems, diabetes, anxiety and depression symptoms, loneliness, age, gender, marital and employment status and education level. | 2020-07-02 |
| 32609845 | Thrombocytopenia is a common complication of influenza virus infection, and its severity predicts the clinical outcome of critically ill patients. | 2020-07-02 |
| 32609906 | Relevant clinical data were mined. | 2020-07-02 |
| 32609908 | These results plead for an early and pro-active screening of COVID-19 symptoms in these populations. | 2020-07-02 |
| 32609971 | We describe the clinical progress and lung ultrasound findings of a Singaporean COVID-19 intensive care unit patient who was diagnosed with COVID-19 infection. […] Methods: The clinical course of one COVID-19 patient managed in the intensive care unit was traced. […] Serial point-of-care bedside lung ultrasound was performed by the managing intensivist daily, and correlated with the clinical progress and chest X-ray imaging done for the patient. […] An increased density or reduction of the B-lines was associated with clinical improvement or deterioration, respectively. […] We describe the clinical progress and lung ultrasound findings of a Singaporean COVID-19 intensive care unit patient who was diagnosed with COVID-19 infection. […] Methods: The clinical course of one COVID-19 patient managed in the intensive care unit was traced. […] Serial point-of-care bedside lung ultrasound was performed by the managing intensivist daily, and correlated with the clinical progress and chest X-ray imaging done for the patient. […] An increased density or reduction of the B-lines was associated with clinical improvement or deterioration, respectively. | 2020-07-02 |
| 32610036 | This clinical sign could help clinicians to diagnose this disease. | 2020-07-02 |
| 32610079 | Here, we explain the protective functions of cytokines in “ideal” responses; the multi-factorial origins that can drive these responses to become pathological; and how this ultimately leads to vascular damage, immunopathology, and worsening clinical outcomes. | 2020-07-02 |
| 32610104 | To evaluate the differences in the clinical presentation of acute appendicitis and CT findings related to these cases between the COVID-19 acute pandemic period and nonpandemic period. | 2020-07-02 |
| 32610153 | More than 2,000 research projects registered at ClinTrials.gov are aiming at finding effective treatments for rapid transfer to clinical practice. […] Unfortunately, just few studies have a sufficiently valid design to provide reliable information for clinical practice. | 2020-07-02 |
| 32610334 | Neurological disorders as sequelae of influenza viruses have been repeatedly documented in the past and include symptoms, signs, and diseases occurring during the acute phase and, not rarely, during follow-up. | 2020-07-02 |
| 32610401 | Methods: A retrospectively analysis was conducted to explore the clinical data of COVID-19 patients who received tracheotomy in February to March 2020, and descriptive statistics were used to analyze the indication of tracheotomy, particularity of intraoperative treatment and protective measures. | 2020-07-02 |
| 32610564 | Quite recently, blood clots have emerged as the common factor unifying many of the symptoms initially attributed without an explanation to COVID-19. […] The ultrasound imaging patterns at both the lung and peripheral vascular level can also be very useful weapons that have the advantage of being able to monitor longitudinally the clinical picture, something that real-time PCR/nasopharyngeal swab is not able to do and that CT can only pursue with significant radiation exposure. | 2020-07-03 |
| 32610613 | This study aims to survey alcohol drinking throughout the pandemic so as to investigate those factors considered most relevant; i.e., sociodemographic and clinical. | 2020-07-03 |
| 32610859 | The aim of this report is to describe the clinical profiles of these Covid-19 infected patients admitted in Sawai Mansingh Hospital(S.M.S), Jaipur ranging from their age, sex, travel history, clinical symptoms, laboratory evaluation, radiological characteristics, treatment provided along with common side effects and the final outcome. […] Epidemiological, clinical, laboratory, and radiological characteristics and treatment and outcomes data were obtained with data collection forms from electronic medical records and history given by 21 Covid-19 infected patients admitted in S.M.S., Jaipur. […] Clinical investigations in initial Covid-19 patients in the Indian subcontinent reveal lymphopenia as predominant finding in hemogram. | 2020-07-03 |
| 32610873 | The present study was undertaken to investigate epidemiological distribution, clinical manifestation, co morbid status, treatment strategy and case fatality index of emerging COVID-19 infection at SMS Medical College Hospital, Jaipur, Rajasthan. […] In an attempt to provide extensive information pertaining to epidemiological and clinical characteristics of COVID-19, the present study was undertaken on 522 patients. […] The indoor admitted patient’s information inclusive of demographic profile (age, sex, nationality, residence), date of confirmation for positive COVID-19 case, travel/ exposure history, date of recovery/ death, clinical features, co morbidities and treatment plan was recorded. […] Out of the total analyzed patients, only 24.32% patients were symptomatic, among them fever (55.90%), cough (52.75%), sore throat (49.60%) and shortness of breath (46.45%) were the most common presenting clinical manifestations while a few patients also had symptoms of headache (26.77%), chest pain (6.29%) and other symptoms (7.87%) like pain abdomen, fatigue, joints pain, altered sensorium etc. […] Interestingly, all deceased (100%) had presented with clinical manifestations of COVID-19 and all had underlying multiple co morbid conditions. […] Fever, cough, sore throat and shortness of breath were major symptoms that could be detected in such COVID-19 patients. […] Symptomatic clinical manifestations were more common in old age population. | 2020-07-03 |
| 32610879 | This timely review discusses the pre-clinical evidence, and data from the eight available clinical trials. | 2020-07-03 |
| 32611247 | Background: Studies on COVID-19 infection in pregnancy thus far have largely focused on characterizing maternal and neonatal clinical characteristics. […] However, this neonate initially tested negative at birth, suggesting that the SARS-CoV-2 infection was likely hospital-acquired rather than vertically transmitted. 13 (8%) neonates had complications or symptoms.Conclusions: The findings of this rapid descriptive review based on early clinical evidence suggest that vertical transmission of SARS-CoV-2 from mother to neonate/newborn did not occur. | 2020-07-03 |
| 32611305 | We are learning almost every day about its new symptoms and that it mutates quickly. | 2020-07-03 |
| 32611385 | Whilst evidence suggests that children are not impacted by COVID-19 as severely as adults, little is still known about their transmission potential, and with a lot of asymptomatic cases they may be silent transmitters (i.e. infectious without showing clinical signs of disease), albeit at a lower level than adults. | 2020-07-03 |
| 32611461 | It has rapidly been injected with an ‘all hands-on deck’ approach, to facilitate the necessary adaptations required to reduce the spread of the virus and deliver frontline clinical care. […] Inevitably aspects of these changes have disrupted the delivery of medical education, notably clinical placements have been cancelled and social distancing guidelines prohibit face-to-face teaching. | 2020-07-03 |
| 32611473 | This paper highlights several clinical, administrative, medicolegal and IT implications of COVID-19 on the delivery of mental healthcare to an elderly vulnerable patient cohort due to recommended social distancing measures. | 2020-07-03 |
| 32611485 | In the majority of cases patients are either asymptomatic or show mild to moderate symptoms and signs of a common cold. | 2020-07-03 |
| 32611558 | Higher quality clinical studies assessing the diagnostic accuracy of serological tests for covid-19 are urgently needed. | 2020-07-03 |
| 32611659 | The possibility of COVID-19 should be considered primarily in patients with new-onset fever or respiratory tract symptoms. […] However, these symptoms can occur with other viral respiratory illnesses. | 2020-07-03 |
| 32611687 | The present review summarizes up-to-date evidence addressing the frequently discussed clinical controversies regarding the use of immune checkpoint inhibitors (ICIs) in cancer patients with viral infections, including AIDS, hepatitis B and C, progressive multifocal leukoencephalopathy, influenza, and COVID-19. | 2020-07-03 |
| 32611701 | These findings suggest that a potential for fomite transmission may persist for hours to days in indoor environments and have implications for assessment of the risk posed by surface contamination in indoor environments.IMPORTANCE Mitigating the transmission of SARS-CoV-2 in clinical settings and public spaces is critically important to reduce the number of COVID-19 cases while effective vaccines and therapeutics are under development. | 2020-07-03 |
| 32611746 | The primary outcomes will be the prevalence and the severity of psychological symptoms in young people and adults (>18 years old) resulting from the impact of COVID-19 pandemic. | 2020-07-03 |
| 32611796 | We utilized remnant stool specimens (n = 79) from 77 patients with gastrointestinal symptoms. | 2020-07-03 |
| 32611911 | This article was aimed to review the evidence on clinical management and to deal with the identification of high-risk groups, warning signs, appropriate investigations, proper sample collection for confirmation, general and specific treatment measures, strategies as well as infection control in the healthcare settings. […] While many drugs have shown in vitro activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there are insufficient clinical data to promote or dissuade their usage. […] Among the currently available drugs, hydroxychloroquine and lopinavir/ritonavir may be considered for patients with severe COVID-19 infection, awaiting further clinical trials. […] Stringent droplet and contact precautions will protect healthcare workers against most clinical exposures to COVID-19. | 2020-07-03 |
| 32611912 | Eye care professionals can be caught unaware because conjunctivitis may be one of the first signs of COVID-19 at presentation, even precluding the emergence of additional symptoms such as dry cough and anosmia. […] Patients should be told to discontinue contact lens wear if they have any symptoms of COVID-19. | 2020-07-03 |
| 32611916 | Until results of clinical trials for HCQ prophylaxis become available, this study provides actionable information for policymakers to protect HCWs at the forefront of COVID-19 response. | 2020-07-03 |
| 32611979 | We analyzed the clinical data of COVID-19 patients in Zhongnan Hospital of Wuhan University who were critical cases with COVID-19 before March 20, 2020. | 2020-07-03 |
| 32612174 | The vast majority of trainees reported a decrease ≥50% of clinical activity (76.4%) and >75% of surgical activity (74.6%). […] A strong agreement was found regarding the worthwhile role of web-based case-presentations in clinical training (91.7%), web-based discussion of edited surgical videos (85.7%) and simulation-based practice (86.9%) in surgical training. | 2020-07-03 |
| 32612435 | COVID-19 can be encountered with different clinical presentations. | 2020-07-03 |
| 32612465 | Case Report: Four family members each presented to the emergency department with fever and upper respiratory symptoms. | 2020-07-03 |
| 32612515 | However, evidence related to the presence of SARS-CoV-2 in the CNS, its direct impact on the CNS, and the contribution to symptoms suffered, remain sparse. […] In addition, we propose several strategies to understand, diagnose, and treat the neurological symptoms of COVID-19. | 2020-07-03 |
| 32612614 | Our review of reported cases shows that the symptoms of SOT patients with COVID-19 are similar to those of the normal population, but their severity and outcomes are worse. | 2020-07-03 |
| 32612615 | COVID-19 presents a wide spectrum of clinical manifestations, which ranges from an asymptomatic infection to a severe pneumonia accompanied by multisystemic failure that can lead to a patient’s death. […] This review describes the general aspects of both COVID-19 and its etiological agent SARS-CoV-2, stressing the similarities with other severe coronavirus infections, such as SARS and MERS, but more importantly, pointing toward the evidence supporting the hypothesis that the clinical spectrum of COVID-19 is a consequence of the corresponding variable spectrum of the immune responses to the virus. | 2020-07-03 |
| 32612712 | These disruptions will call on clinicians to have greater consideration for non-operative treatment options to help manage patient symptoms and provide therapeutic care in lieu of the traditional surgical management course of action. […] It is imperative that clinicians and patients consider non-operative, conservative treatment options in order to manage conditions and symptoms until surgical management options become available again, and to manage the increased surgical waitlists caused by the elective surgery shutdowns. | 2020-07-03 |
| 32612804 | A preliminary search identified the following drugs as being used to treat COVID-19 symptoms: atazanavir (ATV), azithromycin (AZI), chloroquine (CLQ)/hydroxychloroquine (HCLQ), dipyridamole, famotidine (FAM), favipiravir, lopinavir/ritonavir (LPV/r), nitazoxanide, remdesivir, ribavirin and tocilizumab. […] Significant caution should be exercised if using any of the medications being trialled for the treatment of COVID-19 until robust clinical trial data are available. | 2020-07-03 |
| 32612961 | Many studies have already evaluated the clinical features of COVID-19, but how it compares with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-negative community-acquired pneumonia (SN-CAP) is still unclear. […] We aimed to analyze the clinical characteristics of COVID-19 in comparison with SN-CAP and find indicators for disease severity in COVID-19. […] Clinical, radiological, and laboratory data were analyzed. […] Compared with SN-CAP, COVID-19 patients had more symptoms of fever and dyspnea; and showed significant difference in blood count results. | 2020-07-03 |
| 32612971 | Morbidity among children was much lower, with milder or absent signs and symptoms; chest CT scans showed milder symptoms, if at all, compared to adults. […] Objective: Report the epidemiological, clinical features, laboratory, radiological characteristics, and treatment of SARS-CoV-2 infections. […] Compare additional signs and symptoms, investigate familial clustering, compare laboratory results, and find out relevance between age and typical chest CT scans in patients. […] Their signs, symptoms, and familial clustering were analyzed. […] Eight (8/33; 24.24%) patients had no symptoms, 12 (12/33; 36.36%) patients had only fever, nine (9/33; 27.27%) patients had fever and additional symptoms, and 12 (12/33; 36.36%) patients had no fever. […] Most children showed clinical features distinguishable from adults and with increased susceptibility within family members. | 2020-07-03 |
| 32613010 | Given the social and economic costs associated with disability due to these conditions, it is imperative that specific considerations for clinical management of these patients be observed. | 2020-07-03 |
| 32613025 | The clinical progression of all cases is described. | 2020-07-03 |
| 32613089 | This multicentric prospective clinical trial seeks to evaluate the efficacy of bilateral lung LD-RT therapy as a treatment for interstitial pneumonia in patients with COVID-19 for improving respiratory function.This prospective study will have 2 phases: I) an exploratory phase enrolling 10 patients, which will assess the feasibility and efficacy of low-dose lung irradiation, evaluated according to an increase in the PaO2/FiO2 ratio of at least 20% at 48-72 h with respect to the pre-irradiation value. | 2020-07-03 |
| 32613199 | Predicting the outcomes of COVID-19 cases using different clinical, laboratory, and imaging parameters is one of the most interesting fields of research in this regard. […] This cross sectional study was carried out on confirmed COVID-19 cases with clinical manifestations and chest CT scan findings based on Iran’s National Guidelines for defining COVID-19. | 2020-07-03 |
| 32613200 | As of today, healthcare practitioners and researchers have made great effort to understand the characteristics and clinical presentations of the disease; however, the existing literature is still incomplete in this regard. | 2020-07-03 |
| 32613255 | Especially in maximum care clinical facilities, a higher exposure to potentially infectious patients or positively tested COVID-19 patients is to be expected. | 2020-07-03 |
| 32613257 | As the viral coat and other viral components are recognized as being foreign by the immune system, this can lead to initial symptoms, which are induced by the very efficiently working immune defense system via the respiratory epithelium. | 2020-07-03 |
| 32613287 | The clinical and CT data of 81 patients with COVID-19 were retrospectively analyzed. […] Besides, a clinical model was also built. […] The correlations of clinical features and textural features were analyzed using the Spearman correlation analysis. […] (2) For clinical features, chi-square tests or Mann-Whitney U tests identified 16 clinical features as significant, and 12 were discriminative (p < 0.05) between two groups analyzed by univariate logistic analysis. […] (3) Prediction models for textural features and clinical features were established, and both showed high predictive accuracy. […] The AUC values of textural features and clinical features were 0.93 (0.86-1.00) and 0.95 (0.95-0.99), respectively. […] (4) The Spearman correlation analysis showed that most textural and clinical features had above-moderate correlations with disease severity (> 0.4). […] • Some textural features showed above-moderate correlations with clinical factors. | 2020-07-03 |
| 32613288 | The novel coronavirus infection has spread worldwide, causing a wide spectrum of clinical manifestations. […] Most patients develop moderate clinical illness, but a substantial number will experience severe pneumonia, which may rapidly progress to acute respiratory distress syndrome and multiple organ failure. […] In this population, soluble urokinase plasminogen activator receptor (suPAR) could serve as a quick triage test and independent marker of clinical severity, hospital and intensive care unit admission, complications, and mortality. | 2020-07-03 |
| 32613314 | COVID-19 is a new disease with many undescribed clinical manifestations. | 2020-07-03 |
| 32613385 | We retrospectevely reviewed 452 electronic medical records of patients admitted to Internal Medicine Department of a secondary hospital in Madrid during Covid 19 pandemic outbreak. […] The cumulative incidence of PE was assessed ant the clinical, analytical and radiological characteristics were compared between patients with and without PE. | 2020-07-03 |
| 32613447 | Sometimes, demise can occur unexpectedly in apparently previous healthy individual after a brief period of trivial flu-like symptoms. | 2020-07-03 |
| 32613637 | New evidence suggests that therapeutic options focusing on antiviral agents may alleviate COVID-19 symptoms as well as those that lead to the decrease in the inflammatory responses. | 2020-07-03 |
| 32613660 | This study evaluates clinical and nutrition characteristics of severely and critically ill patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and investigates the relationship between nutrition risk and clinical outcomes. […] Clinical data and outcomes information were collected and nutrition risk was assessed using Nutritional Risk Screening 2002 (NRS). | 2020-07-03 |
| 32613916 | A protocol was established that utilises risk stratification, early investigation prior to clinical review and a reduction in aerosol generating procedures to lessen the risk of coronavirus disease 2019 spread. […] Clinical encounters and aerosol generating procedures were minimised. | 2020-07-03 |
| 32613918 | This material specifically aims to inform clinical practices in countries where clinics and operating theatres are reopening for elective work. […] As evidence continues to build, some of the recommended practices will undoubtedly evolve, but it is hoped that the updated position statement will offer clinicians precepts on safe clinical practice. | 2020-07-03 |
| 32613924 | Anxiety symptoms among older adults have been connected with various psychological outcomes, including social isolation and loneliness. […] Accordingly, the current study examined the moderating role of COVID-19-related ageism in the connection between COVID-19 health worries and anxiety symptoms among older adults. […] Data were collected from 243 older adults (age range 60-92; M = 69.75, SD = 6.69), who completed scales assessing COVID-19-related health worries and ageism, as well as anxiety symptoms. […] The results demonstrated that both health worries and ageism were positively associated with anxiety symptoms. […] Moreover, the connection between health worries and anxiety symptoms was more pronounced among older adults with high ageism levels. | 2020-07-03 |
| 32613929 | Over the years, the practice of medicine has evolved from authority-based to experience-based to evidence-based with the introduction of the scientific process, clinical trials, and outcomes-based data analysis (Tebala GD. […] The time required to perform the necessary randomized controlled trials, a systematic literature review, and meta-analysis of these trials to then create, accept, promulgate, and educate the practicing clinicians to use the evidence-based clinical guidelines is typically measured in years. […] When the severe acute respiratory syndrome novel coronavirus-2 (SARS-nCoV-2) pandemic commenced in Wuhan, China at the end of 2019, there were few available clinical guidelines to deploy, let alone adapt and adopt to treat the surge of coronavirus disease 2019 (COVID-19) patients. […] The aim of this study is to first explain how clinical guidelines, on which bedside clinicians have grown accustomed, can be created in the midst of a pandemic, with an evolving scientific understanding of the pathophysiology of the hypercoagulable state. […] The second is to adapt and adopt current venous thromboembolism diagnostic and treatment guidelines, while relying on the limited available observational reporting of COVID-19 patients to create a comprehensive clinical guideline to treat COVID-19 patients. | 2020-07-03 |
| 32613939 | Their active surveillance has increased data accuracy and utility for syndromic conditions (e.g. encephalitis), pathogen-specific diseases (e.g. pertussis, rotavirus, influenza), and adverse events following immunisation (e.g. febrile seizure), enabled correlation of biological specimens with clinical context and supported responses to emerging infections (e.g. pandemic influenza, parechovirus, COVID-19). | 2020-07-03 |
| 32614251 | Case Presentation: A 20-year-old pregnant woman with no symptoms of COVID-19 presented to the hospital for delivery at 39 weeks of gestation. | 2020-07-03 |
| 32614258 | Materials and Methods In this retrospective study, clinical and imaging data of patients seen between March 1, 2020, and April 6, 2020, who tested positive for COVID-19 and experienced barotrauma associated with invasive mechanical ventilation, were compared with patients without COVID-19 infection during the same period. | 2020-07-03 |
| 32614283 | The current COVID-19 pandemic has revealed a series of unprecedented challenges to syndromic surveillance including: the impact of media reporting during early stages of the pandemic; changes in healthcare-seeking behaviour resulting from government guidance on social distancing and accessing healthcare services; and changes in clinical coding and patient management systems. | 2020-07-03 |
| 32614284 | On the other hand, these recommendations should have a dynamic evolution, depending on the upward or downward trend of the COVID-19 pandemic at regional and local level, but also according to the findings of professional and academic societies, requiring regular reviews based on the publica tion of further recommendations or international clinical trials. | 2020-07-03 |
| 32614385 | A panel of neurologists adjudicated the primary outcome of acute ischemic stroke and its clinical characteristics, mechanisms, and outcomes. | 2020-07-03 |
| 32614442 | To understand the evolution of these symptoms during the course of the disease is important to identify patients with persistent loss of smell or taste and estimate the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the burden of olfactory and gustative dysfunctions. […] The evaluation of the evolution of altered sense of smell or taste in the 113 patients reporting sudden onset of these symptoms at baseline showed that 55 patients (48.7%; 95% CI, 39.2-58.3) reported complete resolution of smell or taste impairment, 46 (40.7%; 95% CI, 31.6-50.4) reported an improvement in the severity, and only 12 (10.6%; 95% CI, 5.6-17.8) reported the symptom was unchanged or worse. […] At 4 weeks from the onset, 89% of the SARS-CoV-2-positive mildly symptomatic patients who had had a sudden onset of altered sense of smell or taste experienced a complete resolution or improvement of these symptoms. | 2020-07-03 |
| 32614464 | We recorded their clinical manifestations, epidemiological history, laboratory examination, and treatment in detail. | 2020-07-03 |
| 32614684 | In this article, many articles published recently are summarized vertically, from the structure and sites of SARS-Cov-2, the mode of transmission, the mathematical model of transmission, the mechanism of the virus itself, the symptoms of patients after infection to medicine used in the early stage period and the prediction as well the analysis of probability in using new medicine. | 2020-07-03 |
| 32614777 | Purpose was further classified into the following categories: news, general information, self-diagnosis, contact tracing, notices to contacts, notification of close cases, awareness, helplines, monitoring of clinical parameters, recording of symptoms and treatment, and messaging with health care professionals. […] The purposes of the apps available in Western languages (107/114, 93.9%) were determined; the most common purposes were general information about COVID-19 (66, 64.0%), COVID-19 news (53, 51.0%), recording of symptoms (53, 51.0%), and contact tracing (51, 47.7%). […] The most common purposes of the apps are providing information on the numbers of infected, recovered, and deceased patients, recording of symptoms, and contact tracing. | 2020-07-03 |
| 32614778 | We conducted an online survey of American adults to assess similarities and differences by race and ethnicity with respect to COVID-19 symptoms, estimates of the extent of the pandemic, knowledge of control measures, and stigma. […] The aim of this study was to describe similarities and differences in COVID-19 symptoms, knowledge, and beliefs by race and ethnicity among adults in the United States. | 2020-07-03 |
| 32614810 | Respondents were contacted 14-21 days after SARS-CoV-2 testing and asked about their demographic characteristics, underlying chronic conditions, symptoms experienced on the date of testing, and potential exposures to SARS-CoV-2 during the 2 weeks before illness onset (or the date of testing among those who did not report symptoms at the time of testing). | 2020-07-03 |
| 32614814 | This COVID-19 outbreak among a young, healthy population with no or mild symptoms was controlled with a coordinated public health response that included rapid contact tracing and testing of all exposed persons. | 2020-07-03 |
| 32614816 | On March 29, 2020, a staff member in a correctional and detention facility in Louisiana developed symptoms† and later had a positive test result for SARS-CoV-2. […] Goals of this investigation included evaluating COVID-19 symptoms in this setting and assessing the effectiveness of serial testing to identify additional persons with SARS-CoV-2 infection as part of efforts to mitigate transmission. […] During May 7-21, testing of 98 incarcerated and detained persons residing in the five quarantined dormitories (A-E) identified an additional 71 cases of SARS-CoV-2 infection; 32 (45%) were among persons who reported no symptoms at the time of testing, including three who were presymptomatic. | 2020-07-03 |
| 32614817 | Here we introduce a transmission model combining age-stratified contact frequencies with age-dependent susceptibility, probability of clinical symptoms, and transmission from asymptomatic (or mild) cases, which we use to estimate the country-specific basic reproductive ratio of COVID-19 for 152 countries. […] This pattern is largely driven by the ratio of children to older adults in each country and the observed propensity of clinical cases in the elderly. | 2020-07-03 |
| 32614854 | Clinical and chest CT data were collected and clinical symptoms, laboratory indicators, and CT images were analyzed to explore CT characteristics and diagnostic value for COVID-19 during pregnancy. | 2020-07-03 |
| 32615038 | This integrated method was successfully applied for detecting SARS-CoV-2 IgM and IgG antibodies in clinical human serum as well as SARS-CoV-2 antigen in pharyngeal swabs from 26 patients with COVID-19 infection and 28 uninfected people. | 2020-07-03 |
| 32615046 | In case of reduced access to eye clinics or high risk of SARS-CoV-2 infection, patients’ management should be stratified based on their clinical presentation. | 2020-07-03 |
| 32615198 | Point prevalence of SARS-CoV-2 carriage across the sites was 2.0% (23/1152 participants), median cycle threshold value 35.70 (IQR:32.42-37.57). 17 were previously symptomatic, two currently symptomatic (isolated anosmia and sore throat); the remainder declared no prior or current symptoms. […] Symptoms in the past month were associated with threefold increased odds of testing positive (aOR 3.46, 95%CI 1.38-8.67; p = 0.008). […] A large proportion (39%) of participants reported symptoms in the past month. […] Development of screening programmes must balance the potential to identify additional cases based upon likely prevalence, expanding the symptoms list to encourage HCW testing, with resource implications and risks of excluding those unlikely to be infectious with positive tests. | 2020-07-03 |
| 32615199 | There is evidence of prolonged virus detection in stool samples, with unclear clinical significance. | 2020-07-03 |
| 32615316 | Identification of frequently mutated variants among COVID-19 patients might be useful for better clinical management, contact tracing, and containment of the disease. | 2020-07-03 |
| 32615326 | Clinical characteristics and oropharyngeal swabs were obtained from 86 patients with COVID-19 hospitalized in Guangzhou Eighth People’s Hospital. […] The interval from onset of hyposmia and hypogeusia to typical COVID-19 symptoms was 0.22 ± 4.57 and 0.75 ± 6.77 days; the interval from onset of hyposmia and hypogeusia to admission was 6.06 ± 6.68 and 5.76 ± 7.68 days; and the duration of hyposmia and hypogeusia was 9.09 ± 5.74 and 7.12 ± 4.66 days, respectively. […] The viral load was high following symptoms onset, peaked within the first week, and gradually declined. | 2020-07-03 |
| 32615528 | He reported upper respiratory signs and symptoms 2 weeks before this presentation. | 2020-07-03 |
| 32615555 | In clinical reports on coronavirus disease 2019 (COVID-19), the incidence of acute kidney injury (AKI) is extremely variable, although AKI is described as an independent risk factor for mortality. | 2020-07-03 |
| 32615569 | In addition, we summarize the in vitro data as well as the available preclinical testing and published clinical reports. | 2020-07-03 |
| 32615619 | While familiarity can be achieved by reviewing the guidelines, clinical case simulations provide a more hands-on approach.Using case-based simulations and current guidance from the Center for Disease Control, American Academy of Pediatrics, and recent reviews, we discuss a management guideline developed at our institution to facilitate provision of care to SARS-CoV-2 infected pregnant women during delivery and to their infants, while protecting health care providers from exposure, and in keeping with the local facility logistics. […] · Integrating simulations of management of SARS-CoV-2 positive pregnant women is feasible in daily clinical routine.. | 2020-07-03 |
| 32615620 | While current research suggests COVID-19 viral antigen is not found in vaginal secretions, its detectability in the female lower genital tract may have clinical implications for obstetric and gynecologic care for women. […] We present a case of a woman at 31 weeks’ gestation with simultaneous upper respiratory symptoms and vulvovaginitis. | 2020-07-03 |
| 32615854 | In response, the Association of Postdoctoral Programs in Clinical Neuropsychology (APPCN) launched a multisite didactic initiative (MDI). | 2020-07-04 |
| 32615862 | There is a pressing need for evidence-based interventions to address the devastating clinical and public health effects of the COVID-19 pandemic. […] To date, a large number of clinical trials addressing various aspects of COVID19 have been registered in the Chinese Clinical Trial Registry (ChiCTR), including more than 200 interventional studies. […] Under such an urgent circumstance, the scope and quality of these clinical studies vary significantly. […] Hence, this review aims to make a comprehensive analysis on the profiles of COVID-19 clinical trials registered in the ChiCTR, including a wide range of characteristics. […] Our findings will provide a useful summary on these clinical studies since most of these studies will encounter major challenges from the design to completion. | 2020-07-04 |
| 32615916 | In total 527 people were identified as close contacts over the same period; 493 were successfully contacted; 445 were located in the NT and were subsequently quarantined and monitored for disease symptoms daily for 14 days after contact with a confirmed COVID-19 case. […] Of these 445 close contacts, 4 tested positive for COVID-19 after developing symptoms; 2/46 contacts who were cruise ship passengers (4.3%, 95% CI 0.5-14.8%) and 2/51 household contacts (3.9%, 95% CI 0.5-13.5%). | 2020-07-04 |
| 32615936 | The early COVID-19 medical literature originated primarily from Asia and focused mainly on clinical features and diagnosis of the disease. | 2020-07-04 |
| 32615987 | At day 8 of ICU admission, the clinical condition improved and patient was extubated. […] The surgeon decided to wait and see the evolution of clinical conditions. | 2020-07-04 |
| 32616030 | We present the clinical features of four cancer patients who were infected with SARS-CoV-2 in late January of 2020 in our hospital. | 2020-07-04 |
| 32616063 | To assess the effect of hydroxychloroquine (HCQ) in reducing SARS-CoV-2 viral shedding by PCR in infected pregnant women with mild symptoms. […] To determine the effect of HCQ on the clinical course and duration of the COVID-19 disease in SARS-CoV-2-infected pregnant women. […] To describe the clinical presentation of SARS-CoV-2 infection during pregnancy. […] Randomized double-blind placebo-controlled two-arm multicentre clinical trial to evaluate the safety and efficacy of HCQ to prevent and/or minimize SARS-CoV-2 infection during pregnancy. […] Study population: pregnant women undergoing routine prenatal follow up or attending emergency units at the participating hospitals who report either symptoms/signs suggestive of COVID-19 disease or close contact with a suspected or confirmed COVID-19 case. […] • Presenting with fever (≥37.5°C) and/or one mild symptom suggestive of COVID-19 disease (cough, dyspnoea, chills, odynophagia, diarrhoea, muscle pain, anosmia, dysgeusia, headache) OR being contact* of a SARS-CoV-2 confirmed or suspected case in the past 14 days • More than 12 weeks of gestation (dated by ultrasonography) • Agreement to deliver in the study hospitals Exclusion criteria • Known hypersensitivity to HCQ or other 4-amonoquinoline compounds • History of retinopathy of any aetiology • Concomitant use of digoxin, cyclosporine, cimetidine • Known liver disease • Clinical history of cardiac pathology including known long QT syndrome • Unable to cooperate with the requirements of the study • Participating in other intervention studies • Delivery onset (characterized by painful uterine contractions and variable changes of the cervix, including some degree of effacement and slower progression of dilatation up to 5 cm for first and subsequent labours) The study participants will be stratified by clinical presentation and SARS-CoV-2 PCR results. | 2020-07-04 |
| 32616067 |
|
2020-07-04 |
| 32616134 | Methods Totally 63 discharged patients in Wuhan,China,who underwent both chest CT and reverse transcription-polymerase chain reaction(RT-PCR)from February 1 to February 29,2020,were included.With RT-PCR as a gold standard,the performance of chest CT in diagnosing COVID-19 was assessed.Patients were divided into mild/moderate and severe/critical groups according to the disease conditions,and clinical features such as sex,age,symptoms,hospital stay,comorbidities,and oxygen therapy were collected.CT images in the recovery phase were reviewed in terms of time from onset,CT features,location of lesions,lobe score,and total CT score. | 2020-07-04 |
| 32616135 | Objective To summarize the clinical characteristics and chest CT findings of coronavirus disease 2019(COVID-19)patients in Peking Union Medical College Hospital(PUMCH). […] Methods A total of 13 patients with COVID-19 confirmed at PUMCH from January 20 to February 6,2020 were selected as the research subjects.Their epidemiological histories,clinical characteristics,laboratory tests,and chest CT findings were analyzed retrospectively.The location,distribution,density,and other accompanying signs of abnormal lung CT lesions were recorded,and the clinical types of these patients were assessed. […] Results The clinical type was “common type” in all these 13 patients aged(46.8±14.7)years(range:27-68 years). […] Conclusions Most of our patients diagnosed with COVID-19 at PUMCH had a travel history to Wuhan or direct contact with patients from Wuhan.The first symptoms of COVID-19 mainly include fever and dry cough,along with normal or reduced counts of WBC and lymphocytes.CT may reveal that the lesions distribute along the bronchi and under the pleura;they are typically localized GGOs in the early stage but can become multiple GGOs and infiltrative consolidation in both lungs in the advanced stage.Scattered vacuole signs may be visible inside the lesions in some patients. | 2020-07-04 |
| 32616381 | Indeed glucocorticoids’ role in regulating this immune response is controversial, and they have been used in clinical practice in a variety of countries, even without a previous clear consensus on their evidence-based benefit. | 2020-07-04 |
| 32616405 | The available literature indicates that telemedicine has been implemented successfully in several common clinical scenarios, including the decision-making process following a diagnosis of nonmetastatic PCa, follow-up care of patients with localized PCa after curative treatments, initial diagnosis of hematuria, management diagnosis and follow-up care of uncomplicated urinary stones and uncomplicated UTIs, and initial evaluation, behavioral therapies, and pelvic floor muscle training in UI patients, as well as follow-up care after surgical treatments of stress urinary incontinence or pelvic organ prolapse. […] The available literature indicates that telemedicine has been adopted successfully in selected patients with several common clinical urological conditions, including prostate cancer, uncomplicated urinary stones, uncomplicated urinary infections, urinary incontinence, or pelvic organ prolapse. | 2020-07-04 |
| 32616467 | In recent years, there has been remarkable progress in the utilization of MSCs in diverse clinical indications both in animal models and human clinical trials. […] In this study, we report quantitative data on the MSC-based clinical trials over the last ten years as they appear on the online database of clinical research studies from US National Institutes of Health. […] In particular, we provide comprehensive review of either completed or ongoing clinical trials using MSCs for virus-associated diseases focusing on HIV, hepatitis B virus and COVID-19 virus. | 2020-07-04 |
| 32616514 | COVID-19 is an entirely new disease with disparate clinical manifestations that are difficult to reconcile with a single pathogenic principle. | 2020-07-04 |
| 32616524 | Therefore, we described the clinical characteristics, laboratory features, treatment and outcomes of CVD complicating SARS-CoV-2 infection. […] Demographic and clinical characteristics, laboratory findings, treatments and clinical outcomes were collected and analysed. […] Clinical characteristics and laboratory findings of patients with COVID-19 with or without new-onset CVD were compared. | 2020-07-04 |
| 32616541 | We present a survey of pathologists within a UK National Health Service cellular pathology department with access to DP, in which we ascertain the role of DP in clinical services during this current pandemic and explore challenges encountered. | 2020-07-04 |
| 32616585 | COVID-19 was diagnosed by detection of Severe Acute Respiratory Syndrome coronavirus 2 in 5 patients and was presumed due to typical clinical and imaging findings in 1 patient. | 2020-07-04 |
| 32616594 | While severe coronavirus infections, including Middle East respiratory syndrome coronavirus (MERS-CoV) cause lung injury with high mortality rates, protective treatment strategies are not approved for clinical use. | 2020-07-04 |
| 32616597 | To develop and validate a machine-learning model based on clinical features for severity risk assessment and triage for COVID-19 patients at hospital admission. 725 patients were used to train and validate the model. | 2020-07-04 |
| 32616673 | Rhesus macaques reinfected with the identical SARS-CoV-2 strain during the early recovery phase of the initial SARS-CoV-2 infection did not show detectable viral dissemination, clinical manifestations of viral disease, or histopathological changes. | 2020-07-04 |
| 32616970 | The weekly frequency of classes was maintained, while the clinical-scientific meetings decreased from ten to three. | 2020-07-04 |
| 32617010 | Clinical, laboratory, and imaging characteristics have been partially described in some observational studies. | 2020-07-04 |
| 32617049 | The most common symptoms of the COVID-19 infection are fever, coughing and shortness of breath. | 2020-07-04 |
| 32617120 | Although the main clinical manifestations of COVID-19 are respiratory symptoms, several reports have noted myocarditis, cardiomyopathy, arrhythmias and cardiac arrests as COVID-19 complications. | 2020-07-04 |
| 32617121 | Even though the leading clinical manifestations of the SARS-CoV-2 infection involve the respiratory tract, there is a non-negligible risk of systemic involvement leading to the onset of multi-organ failure with fatal consequences. […] Since the onset of COVID-19, patients with underlying cardiovascular disease have been at increased risk of poor clinical outcomes with higher death rates. […] Herein, the authors discuss the mechanisms leading to myocardial and microvascular injury in SARS-CoV-2 infection and their clinical implications. | 2020-07-04 |
| 32617169 | One such medication includes the antimalarial hydroxychloroquine (HCQ), which recently reported as a possible therapy for shortening the duration of COVID-19 symptoms, reducing inflammatory reactions to infection, impairing the exacerbation of pneumonia and boosting lung imaging findings. | 2020-07-04 |
| 32617223 | This case report highlights the importance of educating COVID-19 positive patients about the precautions, as well as signs and symptoms of a superimposed bacterial infection, when their plan of care is in a home setting. | 2020-07-04 |
| 32617299 | Several studies from China have recently provided the evidence of epidemiological, clinical, laboratory, and outcomes of COVID-19 patients. […] Clinical data were evaluated and patients were classified to mild, common, severe and critical group. […] Based on the CT scoring, 2, 35, 55 and 6 patients were categorized to grade 0, grade 1, grade 2 and grade 3, respectively, which significantly consistent with clinical classification (kappa =0.638, P﹤0.05). | 2020-07-04 |
| 32617313 | This conclusion is supported by an updated analysis of pathogenesis and clinical progression of this infectious disease. | 2020-07-04 |
| 32617354 | The clinical profile of children with COVID-19 is unknown due to the few number of cases reported. […] A review of the literature published from June 2019 to March 2020 was undertaken to evaluate the clinical presentation, management and outcomes of COVID-19 in in children. […] Asymptomatic cases represented 14.3% (n = 117) of the total number of cases identified, and thus the remaining 85.7% (n = 703) experienced symptoms. […] Diarrhoea and sore throats were less common symptoms, 7.9% (n = 7) and 9.0% (n = 8) respectively. […] Other symptoms, including fatigue, headache and dizziness were rare. | 2020-07-04 |
| 32617402 | Background and study aims The COVID-19 pandemic is having a major clinical and also organizational impact on national health care systems, particularly in high-volume hospitals that are utilized for several essential clinical needs. […] Patients and methods This was an observational prospective study exploring major clinical and organizational changes in endoscopic management at the IBD Center - CEMAD of the Fondazione Policlinico Gemelli IRCCS, Rome, Italy since the beginning of SARS-CoV-2 pandemic. | 2020-07-04 |
| 32617414 | We therefore propose research in three broad areas as urgently needed to inform responses in low- and middle-income countries: transmission patterns of SARS-CoV-2, the clinical characteristics of the disease, and the impact of pandemic prevention and response measures. | 2020-07-04 |
| 32617666 | Due to the small number of cases in our observational study, a specific ophthalmological clinical pattern related to SARS-CoV‑2 infections cannot currently be identified; however, the increased occurrence of subconjunctival hemorrhage in intensive care SARS-CoV‑2 patients is remarkable. […] It remains unclear how ocular symptoms in SARS-CoV‑2 infections are related or how they occur in different stages of the disease. | 2020-07-04 |
| 32617738 | In this study, we evaluated the most frequent neurological symptoms in a cohort of hospitalized COVID-19 patients, and also investigated the possible relationship between plasmatic inflammatory indices and olfactory disorders (ODs) and between muscle pain and creatine kinase (CK). […] A structured questionnaire concerning typical and neurological symptoms, focusing on headache, dizziness, ODs, taste disorders (TDs), and muscle pain, was administrated by telephone interviews. […] Common neurological symptoms were reported in the early phase of the disease, with a median onset ranging from 1 to 3 days. […] Headache in association with arthralgia and muscle pain seems to reflect the common symptoms of the flu-like syndrome, and not COVID-19 infection-specific. | 2020-07-04 |
| 32617741 | In the present study, 399 patients of RADAR-MS have been included (mean age 43.9 years, 60.7% females) with 87/399 patients (21.8%) reporting major symptoms suggestive of COVID-19. […] A trend for an increased risk of COVID-19 symptoms under alemtuzumab and cladribine treatments in comparison to injectables was observed. | 2020-07-04 |
| 32617807 | COVID-19 is associated with a variety of clinical complications including coagulopathy, which frequently results in venous thromboembolism (VTE). […] The rate of VTE was numerically higher in SARS-CoV-2 positive all-comers presenting with suspected COVID-19 as compared to well-matched controls suffering from similar symptoms. | 2020-07-04 |
| 32617983 | PHQ-2 and GAD-2 scores were not associated with severities of any other symptoms during the COVID-19 course. […] Despite the occurrence of symptoms-such as SOB-associated with severe manifestations of COVID-19, only the severities of smell and taste loss were associated with depressed mood and anxiety. | 2020-07-04 |
| 32617986 | There is limited information describing the characteristics and clinical outcomes of patients infected with coronavirus disease 2019 (COVID-19) especially those in underserved urban area with minority population in the United States. […] Demographic, clinical, laboratory, and treatment data were presented using descriptive statistics and frequencies. […] The χ2 test and multivariate logistic regression were used to determine association of risk factors and clinical outcomes. | 2020-07-04 |
| 32617987 | A number of potential drugs/vaccines as well as antibody/cytokine-based therapeutics are in various developmental stages of preclinical/clinical trials against SARS-CoV, MERS-CoV, and 2019-nCoV with substantial cross-reactivity, and may be used against COVID-19. | 2020-07-04 |
| 32618147 | We developed and evaluated a self-assessment questionnaire consisting of 23 symptoms with linear-scale scores from 0 to 10. […] Patients were asked to indicate their worst score for each symptom daily, and medical personnel assessed clinical improvement or deterioration based on the changes in scores. […] Focused communication on severity of specific symptoms was the primary advantage for the clinicians, and a thorough check for their symptoms was helpful for patients. | 2020-07-04 |
| 32618198 | Diabetes is associated with increased COVID-19 severity and mortality, and accumulating evidence suggests that IBTs may favorably alter the clinical course of SARS-CoV-2 infection due to their inherent mechanisms of action. | 2020-07-04 |
| 32618260 | Our understanding of SARS-CoV-2, the virus responsible for coronavirus disease 2019 (COVID-19), its clinical manifestations, and treatment options continues to evolve at an unparalleled pace. […] This review sought to summarize the key literature regarding transmission, case definitions, clinical management, and the burden of COVID-19. […] The commonly reported symptoms were fever (75.3% ± 18.7%) and cough (62.6% ± 17.7%) across the spectrum of clinical disease-mild, moderate, severe, and critical, but with the disease phenotype varying with severity. […] The presence of fever and cough may be sufficient to warrant COVID-19 testing, but using these symptoms in isolation will miss a proportion of cases. […] A clear definition of a COVID-19 case is essential for the management, treatment, and tracking of clinical illness, and to inform the quarantine measures and social distancing that can help control the spread of SARS-CoV-2. | 2020-07-04 |
| 32618262 | Our study aimed at assessing 1) CXR manifestations, frequency, and distribution; 2) the feasibility and repeatability of a CXR severity score; and 3) the correlation between the CXR severity score and clinical and laboratory parameters. […] We reviewed baseline CXRs and clinical data of consecutive patients who presented to our emergency department and resulted positive at SARS-CoV-2 reverse transcriptase-PCR oropharyngeal swab test from March 1, 2020 to April 6, 2020. […] Correlations between the CXR score and the clinical data were assessed. […] The use of a visual CXR score, easy to assess and highly reproducible, can reflect the clinical severity and help the patients’ management. | 2020-07-04 |
| 32618402 | Clinical data on COVID-19-infected patients with psoriasis or psoriatic arthritis are still scarce. […] The patient infected with COVID-19 on apremilast and the one on apremilast with infected spouse showed the best safety profile and mildest symptoms. […] Even though more clinical data are yet needed to draw strong conclusions, apremilast could be a safer alternative for dermatology and rheumatology patients in case of clinically important active infection. | 2020-07-04 |
| 32618462 | To explore the current situation faced by Latin American urology departments during the COVID-19 Outbreak in terms of knowledge, actions, prioritization of urology practices, and implementation of internal clinical management protocols for inpatients and outpatients. […] Regarding to PPE and internal management protocols, 88% confirmed the implementation of specific protocols and 45.4% have not received training to perform a safe clinical practice; only 2.3% reported being infected with COVID-19. | 2020-07-04 |
| 32618463 | COVID-19 disease caused by infection with the SARS-CoV-2 virus produces respiratory symptoms, predominantly of the upper airways, which can progress to pneumonia after 7 days with persistent fever, cough and dyspnea, and even develop a syndrome of acute respiratory distress (ARDS), multi-organ failure and death. […] One of the goals to be achieved is for patients to recover and be able to successfully return to work; for this purpose, an adequate physical and psychological rehabilitation program is essential, as about 50% have symptoms of anxiety and depression. | 2020-07-04 |
| 32618497 | Coronavirus disease 2019 (COVID-19) has a wide spectrum of disease severity from mild upper respiratory symptoms to respiratory failure. […] The median number of days to reach the peak Nab titers after symptoms onset was shorter among the ICU patients (17.6) than that of the non-ICU patients (20.1). […] Multivariate analysis showed that oxygen requirement and fever during admission were the only clinical factors independently associated with higher NAb titers. | 2020-07-04 |
| 32618498 | Anecdotal reports and clinical observations have recently emerged suggesting a relationship between COVID-19 disease and stroke, highlighting the possibility that infected individuals may be more susceptible to cerebrovascular events. | 2020-07-04 |
| 32618648 | Although COVID-19 is principally defined by its respiratory symptoms, it is now clear that the virus can also affect the digestive system. […] In this review, we elaborate on the close relationship between COVID-19 and the digestive system, focusing on both the clinical findings and potential underlying mechanisms of COVID-19 gastrointestinal pathogenesis. | 2020-07-04 |
| 32618658 | Epidemiological, demographic, clinical, laboratory, treatment, and outcome data were collected and compared. […] No differences in disease severity and clinical outcomes were noted between the groups. | 2020-07-04 |
| 32618665 | A total of 207 patients were identified; 34.5% of patients noted concurrent gastrointestinal symptoms, with 90% of gastrointestinal symptoms being mild. […] The presence of digestive symptoms in COVID-19 is associated with a need for hospitalization. | 2020-07-04 |
| 32618693 | Mechanical ventilation is lifesaving for respiratory distress, this study was designed to delineate the clinical features of the coronavirus disease 2019 patients with mechanical ventilation from a national cohort in China. | 2020-07-04 |
| 32618839 | Although the main clinical manifestation of COVID-19 is respiratory involvement, there is evidence suggesting the neuroinvasive potential of COVID-19. […] The medical history was positive for flu-like symptoms affecting all the members of his family. […] Similar to her father, the paraclinical evaluations were consistent with Guillain-Barré syndrome. […] Taking into account clinical findings and the outbreak of COVID-19, the suspicion of COVID-19 was proposed. | 2020-07-04 |
| 32618909 | The diagnosis and management of such patients can be complicated as their clinical characteristics are heterogeneous. | 2020-07-04 |
| 32618932 | Children with coronavirus disease 2019 (COVID-19) are more likely to have mild or no symptoms compared with adults and may represent important vectors for transmitting the virus. | 2020-07-04 |
| 32618968 | We recorded the daily number of trauma patients diagnosed with SARS-CoV-2 infection, the presence of clinical symptoms or radiological signs of COVID-19, and the results of verbal symptom screen (for new admissions). […] Positive verbal screen results, presence of ground glass opacities on admission chest CT, and presence of clinical symptoms were not significantly different in patients with or without SARS-CoV-2 infection (p > 0.05). […] Many infected patients were without clinical symptoms (9/21, 43%) or radiological signs on admission (18/21, 86%) of COVID-19. […] Respiratory symptoms, as well as verbal screening (recent fevers, shortness of breath, cough, international travel, and close contact with known SARS-CoV-2 carriers), are inaccurate in the trauma population. | 2020-07-04 |
| 32619034 | There is little information available regarding the clinical features of hematological patients concomitant with COVID-19. […] In this study, 9 concomitant patients were analyzed for their clinical manifestations, laboratory data, radiological findings, and immunologic features. […] Our results indicated concomitant patients formed a distinct subgroup characterized by atypical clinical features, defective viral clearance, and lower level of SARS-CoV-2-specific Abs. | 2020-07-04 |
| 32619318 | A comprehensive text-mining and manual curation approach was used to comb and summarize the most pertinent information from existing clinical trials and previous efforts to develop therapies against related betacoronaviruses, particularly SARS and MERS. […] Due to the rapid containment of the prior epidemics, however, these were generally not followed up with in vivo animal studies or clinical investigations and thus largely overlooked as treatment prospects in the current COVID-19 trials. […] This brief review summarizes and tabulates core information on recent or ongoing drug repurposing-focused clinical trials, while detailing the most promising untested candidates with prior documented success against the aetiologic agents of SARS and/or MERS. | 2020-07-04 |
| 32619408 | Frailty is being used in clinical decision making for patients with COVID-19, yet the prevalence and effect of frailty in people with COVID-19 is not known. […] Frailty was assessed by specialist COVID-19 teams using the clinical frailty scale (CFS) and patients were grouped according to their score (1-2=fit; 3-4=vulnerable, but not frail; 5-6=initial signs of frailty but with some degree of independence; and 7-9=severe or very severe frailty). | 2020-07-04 |
| 32619411 | We assessed correlations between these laboratory results with clinical outcomes, including hospital discharge and mortality. | 2020-07-04 |
| 32619549 | Here, we present a platform for ultra-high-throughput serum and plasma proteomics that builds on ISO13485 standardization to facilitate simple implementation in regulated clinical laboratories. […] In total, this work supports the development of routine proteomic assays to aid clinical decision making and generate hypotheses about potential COVID-19 therapeutic targets. | 2020-07-04 |
| 32619697 | According to the clinical history, we discuss either re-infection or reactivation hypothesis. | 2020-07-04 |
| 32619700 | The web interface also provides access to an easy-to-use API that allows a wide use for other software and applications, e.g., for meta-analysis, design of new clinical studies, or simple literature search. | 2020-07-04 |
| 32619756 | The dramatic increase in suspected COVID-19 cases in Africa has placed an enormous burden on public and private clinical facilities. […] The review highlights the urgent need for speedy expansion and distribution of several laboratory testing platforms, including real-time PCR and serological assays to both public health facilities and fully accredited private clinical laboratories. | 2020-07-04 |
| 32619760 | The clinical course and viral RNA shedding pattern of 267 consecutive symptomatic COVID-19 patients admitted to the hospital from January 20, 2020 to March 15, 2020 were evaluated retrospectively. | 2020-07-04 |
| 32619764 | Evidence of clinical improvement in patients with severe COVID-19 treated with remdesivir is controversial. […] The aim of this study was to describe the clinical outcomes and virological monitoring of the first five COVID-19 patients admitted to the intensive care unit of Bichat-Claude Bernard University Hospital, Paris, France, for severe pneumonia related to SARS-CoV-2 and treated with remdesivir. | 2020-07-04 |
| 32619766 | The most important criteria (mean weights, summing to 100%) are: PaO2 (16.3%); peripheral O2 saturation (15.9%); chest X-ray (14.1%); Modified Early Warning Score-MEWS (11.4%); respiratory rate (9.5%); comorbidities (6.5%); living with vulnerable people (6.4%); body mass index (5.6%); duration of symptoms before hospital evaluation (5.4%); CRP (5.1%); and age (3.8%). | 2020-07-04 |
| 32619773 | Detection of superimposed infection in patients with cancers who present with pulmonary infiltrations warrant correlation with clinical picture, contact history, and RT-PCR confirmatory testing. | 2020-07-04 |
| 32619819 | The first case was identified in a patient with flu symptoms along with severe acute respiratory syndrome in Wuhan, China in December 2019 and now it has spread in more than 200 countries. | 2020-07-04 |
| 32619835 | Psychiatric hospitals play an important role in supporting patients with mental illness to relieve symptoms and improve functioning in a physically and psychologically safe environment. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. […] Demographic data, clinical records, laboratory tests, and outcomes were collected. | 2020-07-04 |
| 32619959 | This preceded a comparison of the methods using previously evaluated clinical specimens (nasopharyngeal swabs) using 116 human specimens tested by both methodologies. […] Evaluation of clinical specimens resulted in fewer inconclusive results by the SARS-CoV-2 assay, leading to potentially higher clinical sensitivity. | 2020-07-04 |
| 32620062 | Clinical research trials around the world are underway testing a wide array of possible medications. […] We aimed to explore how opinions toward hydroxychloroquine may shift from early enthusiasm (based on in vitro and preliminary clinical data) to the hope for a miracle cure (through communication and promotion of questionable results) and, finally, to a rise of skepticism as more in-depth analyses are emerging. | 2020-07-05 |
| 32620118 | Many patients with COVID-19 have symptoms of acute respiratory distress syndrome, even are in danger of death. […] This is the first study to evaluate dynamic changes of D-Dimer and Neutrophil-Lymphocyte Count Ratio (NLR) as a prognostic utility in patients with COVID-19 for clinical use. | 2020-07-05 |
| 32620125 | Early prediction of the clinical progression was essential but still unclear. […] Epidemiological feature, clinical records, laboratory and radiology manifestations were collected and analyzed. 323 patients with mild-moderate symptoms on admission were observed to determine whether they exacerbated to severe-critically ill conditions (progressive group) or not (stable group). […] We used logistic regression to identify the risk factors associated with clinical progression. […] Of all the 333 patients, 70 (21.0%) patients progressed into severe-critically ill conditions during hospitalization and assigned to the progressive group, 253 (76.0%) patients belonged to the stable group, another 10 patients were severe before admission. we found that the clinical features of aged over 40 (3.80 [1.72, 8.52]), males (2.21 [1.20, 4.07]), with comorbidities (1.78 [1.13, 2.81]) certain exposure history (0.38 [0.20, 0.71]), abnormal radiology manifestations (3.56 [1.13, 11.40]), low level of T lymphocytes (0.99 [0.997, 0.999]), high level of NLR (0.99 [0.97, 1.01]), IL-6 (1.05 [1.03, 1.07]) and CRP (1.67 [1.12, 2.47]) were the risk factors of disease progression by logistic regression. […] The potential risk factors of males, older age, with comorbidities, low T lymphocyte level and high level of NLR, CRP, IL-6 can help to predict clinical progression of COVID-19 at an early stage. | 2020-07-05 |
| 32620144 | This is a single centre, 2-arm (1:1 ratio), evaluator blinded, parallel group design superiority randomised, controlled clinical trial. […] The secondary outcome measures include nucleic acid test rate and recovery from symptoms, Vital signs assessment, Computed Tomography, Complete blood count, serum analysis and SIRS scale scores. […] This randomised controlled trial has been prospectively registered with the Chinese Clinical Trials (ChiCTR2000029972) on 17 February 2020. […] The study protocol has been reported in accordance with the Standard Protocol Items: Recommendations for Clinical Interventional Trials (SPIRIT) guidelines (Additional file 2). | 2020-07-05 |
| 32620178 | To investigate the possibility of earlier cases of severe acute respiratory syndrome coronavirus 2 infection than previously recognized, we retrospectively tested pooled samples from 1,700 persons with respiratory signs/symptoms seen at Stanford Health Care, Palo Alto, California, USA, during the last 2 months of 2019. | 2020-07-05 |
| 32620182 | Evidence of antibodies to SARS-CoV-2 was detected in 1 evacuee, who reported experiencing no symptoms or high-risk exposures in the previous 2 months. | 2020-07-05 |
| 32620220 | However, over time, SARS-CoV and MERS-CoV were shown to cause extrapulmonary signs and symptoms including hepatitis, acute renal failure, encephalitis, myositis and gastroenteritis. | 2020-07-05 |
| 32620267 | Three patients were COVID-positive, although none had respiratory symptoms. | 2020-07-05 |
| 32620311 | Every patient sent a daily clinical questionnaire with temperature and oxygen saturation 3 times a day. | 2020-07-05 |
| 32620371 | Health-seeking behaviors change during pandemics and may increase with regard to illnesses with symptoms similar to the pandemic. | 2020-07-05 |
| 32620500 | Since severe acute respiratory failure appears to be the leading cause of death for COVID-19 patients, it is essential to focus on this clinical feature. | 2020-07-05 |
| 32620590 | We retrospectively reviewed consecutive patients presenting to the emergency department with symptoms suggestive of COVID-19 and undergoing swab tests for SARS-CoV-2. […] In conclusion, CBC-based scores have potential for optimising the SARS-CoV-2 testing process: if these findings are confirmed in the future, swab tests may be waived for subjects with low score and uncertain symptoms, while they may be considered for asymptomatic or oligosymptomatic patients with high scores. | 2020-07-05 |
| 32620597 | Clinical improvement, mortality, safety and predictors of response were assessed at 28 days. […] At day 28 of follow-up, 61% of patients treated with sarilumab experienced clinical improvement and 7% died. […] These findings were not significantly different from the comparison group (clinical improvement 64%, mortality 18%; p=NS). […] Baseline PaO2/FiO2 ratio >100 mm Hg and lung consolidation <17% at CT scan predicted clinical improvement in patients treated with sarilumab. […] Median time to clinical improvement in patients with lung consolidation <17% was shorter after sarilumab (10 days) than after standard treatment (24 days; p=0.01). […] At day 28, overall clinical improvement and mortality in patients with severe COVID-19 were not significantly different between sarilumab and standard of care. | 2020-07-05 |
| 32620678 | The pandemic has had a substantial impact on clinical services, including cancer pathways. […] Pathologists are working remotely in many circumstances to protect themselves, colleagues, family members and the delivery of clinical services. […] The effects of COVID-19 on research and clinical trials have also been significant with changes to protocols, suspensions of studies and redeployment of resources to COVID-19. […] In this article, we explore the specific impact of COVID-19 on clinical and academic pathology and explore how digital pathology and artificial intelligence can play a key role to safeguarding clinical services and pathology-based research in the current climate and in the future. | 2020-07-05 |
| 32620682 | Cancer diagnosis, among other clinical features, increases the risk of poor outcome of COVID-19 infection. […] COVID-19 infection caused significant clinical deterioration in this patient. | 2020-07-05 |
| 32620916 | These findings were associated with the analytical and clinical symptoms, which helps us understand the respiratory insufficiency and reveal the histological substrate for the macrophage activation syndrome-like exhibited by these patients. | 2020-07-05 |
| 32620975 | To mine Twitter and quantitatively analyze COVID-19 symptoms self-reported by users, compare symptom distributions across studies, and create a symptom lexicon for future research. […] We extracted COVID-19-related symptoms mentioned by the users, mapped them to standard concept IDs in the Unified Medical Language System, and compared the distributions to those reported in early studies from clinical settings. […] We identified 203 positive-tested users who reported 1002 symptoms using 668 unique expressions. […] The most frequently-reported symptoms were fever/pyrexia (66.1%), cough (57.9%), body ache/pain (42.7%), fatigue (42.1%), headache (37.4%), and dyspnea (36.3%) amongst users who reported at least 1 symptom. […] Mild symptoms, such as anosmia (28.7%) and ageusia (28.1%), were frequently reported on Twitter, but not in clinical studies. […] The spectrum of COVID-19 symptoms identified from Twitter may complement those identified in clinical settings. | 2020-07-05 |
| 32621013 | Imaging should be performed only when expected to alter patient management, depending on symptoms, preexisting conditions and clinical evolution. | 2020-07-05 |
| 32621202 | We performed a single-center, retrospective analysis of hospitalized adult COVID-19 patients in Wuhan, China, who had definite clinical outcome (dead or discharged) by February 15, 2020. […] Patients on anti-hypertensive treatment with or without ACEI/ARB were compared on their clinical characteristics and outcomes. […] The medical records from 702 patients were screened. | 2020-07-05 |
| 32621237 | Nomogram performance was determined by its discrimination, calibration, and clinical usefulness. […] The mixed model achieved better predictive efficacy than the clinical model. […] The radiomics model derived has good performance for predicting COVID-19 pneumonia and may help in clinical decision-making. […] • A radiomics model was superior to a clinical model in predicting 2019 novel coronavirus pneumonia. | 2020-07-05 |
| 32621241 | • In clinical practice, in a context of growing epidemic, in France, chest CT was used as a surrogate to RT-PCR for patient triage. | 2020-07-05 |
| 32621284 | Furthermore, reported risk of infections of biologic and non-biologic therapeutics for skin diseases from clinical trials and drug data registries were evaluated. | 2020-07-05 |
| 32621438 | To reduce the stress of clinical medical staff and prevent excessive protection, we enhance the training mechanisms and promote the superior normative guidance. […] The aim is to fully play the effectiveness of the key departments of medical protective consumables, reduce the risk of infection of clinical medical staff and ensure the safety of medical staffs. | 2020-07-05 |
| 32621523 | Two of 5 (20%) had moderate disease and received remdesivir as part of a clinical trial and reduced immunosuppression therapy. […] All OHT patients managed under our clinical management algorithm had good short-term outcomes. | 2020-07-05 |
| 32621527 | Nephrology operational readiness for COVID-19 requires a clinical mindset shift from usual standard of care to a crisis exigency model that targets best outcomes for available resources. | 2020-07-05 |
| 32621621 | Sixty-four cases were coinfected with influenza A/B and the other 64 were influenza negative, matched by age, sex, and days from onset of symptoms. | 2020-07-05 |
| 32621814 | This review will discuss the performance of different laboratory diagnostic tests and platforms, as well as suitable clinical samples for testing, and related biosafety protection. | 2020-07-05 |
| 32621881 | A single-center retrospective chart review was undertaken and included all patients with (1) symptoms of COVID-19 and (2) PCR-positive nasopharyngeal swabs for SARS-CoV-2 who were placed on continuous telemetry for the duration of their hospitalization during March through May, 2020. | 2020-07-05 |
| 32622086 | In the first two decades of the 21st century, there have been three outbreaks of severe respiratory infections caused by highly pathogenic coronaviruses (CoVs) around the world: the severe acute respiratory syndrome (SARS) by the SARS-CoV in 2002-2003, the Middle East respiratory syndrome (MERS) by the MERS-CoV in June 2012, and Coronavirus Disease 2019 (COVID-19) by the SARS-CoV-2 presently affecting most countries In all of these, fatalities are a consequence of a multiorgan dysregulation caused by pulmonary, renal, cardiac, and circulatory damage; however, COVID patients may show significant neurological signs and symptoms such as headache, nausea, vomiting, and sensory disturbances, the most prominent being anosmia and ageusia. […] The neuroinvasive potential of CoVs might be responsible for at least part of these symptoms and may contribute to the respiratory failure observed in affected patients. […] Therefore, in the present manuscript, we have reviewed the available preclinical evidence on the mechanisms and consequences of CoVs-induced CNS damage, and highlighted the potential role of CoVs in determining or aggravating acute and long-term neurological diseases in infected individuals. […] We consider that a widespread awareness of the significant neurotropism of CoVs might contribute to an earlier recognition of the signs and symptoms of viral-induced CNS damage. | 2020-07-05 |
| 32622172 | The COVID-19 pandemic could result in increased psychiatric disorders such as Post-Traumatic Stress, Depressive, and Anxiety Disorders, as well as grief-related symptoms. […] Adolescents with psychiatric disorders are at risk of a break or change in their care and management; they may experience increased symptoms. | 2020-07-05 |
| 32622186 | After an otherwise unevenful postoperative course, on post-operative day 8, the patient suddenly presented hyperpyrexia and cough, rapidly evolving to respiratory failure and death 36 h after symptoms onset. […] A previous contact with the partner, developing the same symptoms, remained unrecognized until ICU admission. […] Persistent hyperleucocytosis and increased CRP serum level in spite of uneventful postoperative course were the only, aspecific markers of an ongoing SARS-CoV-2 infection before symptoms’ onset, and should be considered in future clinical practice in order to adopt the prompt and appropriate patient management and limit COVID-19 contagion in surgical units. | 2020-07-05 |
| 32622261 | Here, we review current information concerning the global health issue of COVID-19 including promising approved drugs and ongoing clinical trials for prospective treatment options. | 2020-07-05 |
| 32622375 | Although the predominant clinical presentation is with respiratory disease, neurological manifestations are being recognised increasingly. […] Anosmia and ageusia are common, and can occur in the absence of other clinical features. […] WHERE NEXT?: Careful clinical, diagnostic, and epidemiological studies are needed to help define the manifestations and burden of neurological disease caused by SARS-CoV-2. | 2020-07-06 |
| 32622380 | We screened health-care workers at the participating hospitals for SARS-CoV-2 infection, based on clinical symptoms (fever or mild respiratory symptoms) in the 10 days before screening. […] We obtained epidemiological data through structured interviews with health-care workers and combined this information with data from whole-genome sequencing of SARS-CoV-2 in clinical samples taken from health-care workers and patients. | 2020-07-06 |
| 32622400 | We aimed to characterise the COVID-19 pandemic in Brazil and assess variations in mortality according to region, ethnicity, comorbidities, and symptoms. | 2020-07-06 |
| 32622411 | Academic research department and clinical diagnostic laboratory. | 2020-07-06 |
| 32622450 | Medical management is mostly supportive with antipyretics, hydration, oxygen supplementation, and other measures as dictated by clinical need. […] Despite the issuance of emergency use authorization for remdesivir, there are still no proven effective antiviral and immunomodulatory therapies, and their use in COVID-19 management should be guided by clinical trial protocols or treatment registries. | 2020-07-06 |
| 32622482 | The organization of care that has been carried out and the clinical course of the 16cases of COVID-19 in hemodialysis patients are summarized. […] The clinical course of these 16patients is compared with the series published by the Wuhan University Hospital and with the data from the COVID-19 infection registry of the Spanish Society of Nephrology. | 2020-07-06 |
| 32622702 | Fertility societies worldwide responded to the COVID-19 pandemic by recommending that fertility clinics close, or sharply reduce, the clinical operation, leading to a shift in the management of IVF laboratories in three phases: shutdown preparation; maintenance during shutdown; and restart. | 2020-07-06 |
| 32622723 | Our meta-analyses found that comparing CHM group and conventional western medicine group, CHM group has improvements in several clinical parameters including lung CT, clinical cure rate, ranging from mild to critical cases, length of hospital stay, total score of clinical symptoms, fever reduction time, symptom score of fever, number of cough reduction cases, symptom score of cough, number of fatigue reduction cases, symptom score of fatigue, disappearing time of fatigue, TCM syndrome, viral nucleic acid testing, and inflammatory biomarkers (C-reactive protein). | 2020-07-06 |
| 32622796 | We retrospectively investigated the clinical and laboratory characteristics of severe COVID-19 patients. 107 patients were divided into hypocalcemia group and normal serum calcium group. […] The clinical and laboratory data were compared between two groups. […] No significant difference was identified in gender, age, signs and symptoms, comorbidities and other laboratory indicators. | 2020-07-06 |
| 32622819 | Health-care providers worldwide in the coronavirus disease 2019 pandemic have been confronted with an unprecedented number of viral lung infections, with great variance in symptoms and severity. | 2020-07-06 |
| 32622882 | The results show that the COVID-19 pandemic has generated symptoms of stress, anxiety, depression and insomnia among health workers, with higher levels among women and older professionals. […] This contributes to the development of diverse psychological symptoms. | 2020-07-06 |
| 32622888 | The registry collected 716 cases of new-onset dermatologic symptoms in patients with confirmed/suspected COVID-19. | 2020-07-06 |
| 32622902 | Tests for coronavirus should be rigorously evaluated in terms of their analytical and clinical performance. […] Problematic for evaluations of the clinical performance of tests for viral RNA is the absence of an independent reference standard. […] Attempts to summarize the performance of these tests in terms of a single estimate of the clinical sensitivity fail to do justice to the identifiable sources of the large heterogeneity in mechanisms for generating false negative results. | 2020-07-06 |
| 32622963 | For this reason, several clinical trials are testing different off-label drugs, already approved for other pathologies. […] Furthermore, more recently, great interest has been devoted to the possible clinical applications of extracellular vesicles secreted by MSCs, nanoparticles that convey much of the biological effects and of the therapeutic efficacy of their cells of origin. | 2020-07-06 |
| 32622993 | A substantial number of clinical trials are planned or underway aimed at assessing the prophylactic benefit of (H)CQ. | 2020-07-06 |
| 32623030 | To investigate the clinical characteristics, laboratory findings and high- resolution CT (HRCT) features and to explore the risk factors for in-hospital death and complications of coronavirus disease 2019 (COVID-19) patients with diabetes. […] Clinical, laboratory and chest CT data were analyzed and compared between the two groups with an admission glucose level of ≤11 mmol/L (group 1) and >11 mmol/L (group 2). | 2020-07-06 |
| 32623040 | T1D, the youngest group, was more susceptible to presenting COVID-19 symptoms despite not being testing; whilst the T2D group had higher frequency of comorbidities that are additional risk factors for COVID-19 severity. | 2020-07-06 |
| 32623083 | A comprehensive strategy - including surveillance, diagnostics, research, and clinical treatment - is urgently needed to win the battle against COVID-19. […] To estimate the incidence of COVID-19 among asymptomatic cases and describe its epidemiological and clinical significance this review systematically examined the published literature on SARS-CoV-2 in asymptomatic patients. | 2020-07-06 |
| 32623113 | In this study population predominantly with mild symptoms and few comorbidities, two-thirds of RT-PCR positive patients had a normal chest CT; whereas the remaining patients showed typical findings of predominant GGOs with a bilateral distribution and peripheral predominance. | 2020-07-06 |
| 32623266 | Regression analyses show that those who have or had COVID-19-related symptoms are more likely to develop general psychiatric disorders and are lonelier. | 2020-07-06 |
| 32623267 | Four of these viruses can cause common cold-like symptoms. | 2020-07-06 |
| 32623296 | Moreover, in the absence of approved drug against COVID-19, infected patients may be included in clinical trials evaluating new drugs with a lack of knowledge, particularly in cancer patients. | 2020-07-06 |
| 32623350 | On samples collected ≥14 days after symptoms onset, the accuracy of the assay is 100 % (95 % CI: 100-100) for the Spike antigen and 99.9 % (95 % CI:99.7-100) for NC. […] By logistic regression, we estimated that 50 % of the patients have seroconverted at 5.7 ± 1.6; 5.7 ± 1.8 and 7.9 ± 1.0 days after symptoms onset against Spike, NC or both antigens, respectively and all have seroconverted two weeks after symptoms onset. | 2020-07-06 |
| 32623414 | The infectious disease specialists are updating the knowledge base in limited time in clinical settings. | 2020-07-06 |
| 32623500 | We aimed to quantitatively assess the global change in surgical and oncological clinical practice in the early COVID-19 pandemic. […] In this cross-sectional observational study, we designed a 12-item online survey on the global effects of the COVID-19 pandemic on clinical practice in urology. […] Demographic survey data, change of clinical practice, current performance of procedures, and current commencement of treatment for 5 conditions in medical urological oncology were evaluated. 235 urologists from 44 countries responded. […] Out of them, 93% indicated a change of clinical practice due to COVID-19. […] The COVID-19 pandemic has affected clinical practice of 93% of urologists worldwide. | 2020-07-06 |
| 32623503 | To describe demographic, clinical, and lung base CT findings in COVID-19 patients presenting with abdominal complaints. […] Demographic and clinical data were extracted. […] The most frequent abdominal symptoms were pain (83.9%) and nausea/vomiting/anorexia (46.8%). […] COVID-19 patients can present with abdominal symptoms, especially in non-elderly patients with underlying health conditions. […] • COVID-19 infected patients can present with acute abdominal symptoms, especially in non-elderly patients with underlying health conditions, and may frequently require hospitalisation (81%). | 2020-07-06 |
| 32623505 | To correlate a CT-based semi-quantitative score of pulmonary involvement in COVID-19 pneumonia with clinical staging of disease and laboratory findings. […] Data were matched with clinical stages and laboratory findings. […] Ground glass opacities were predominant in early-phase (≤ 7 days since symptoms’ onset), while crazy-paving pattern, consolidation, and fibrosis characterized late-phase disease (> 7 days). […] • CT score is positively correlated with age, inflammatory biomarkers, severity of clinical categories, and disease phases. | 2020-07-06 |
| 32623546 | There is a growing body of reports indicating that COVID-19 patients, especially those in severe condition, exhibit neurological symptoms, thus supporting the possibility that SARS-CoV-2 could infect and damage neurons within the central nervous system in humans. […] From this perspective, we elaborate on the idea that the neuro-invasive potential of SARS-CoV-2 should be considered as a possible contributory factor, as well as a therapeutic target, for the severe respiratory symptoms in critical COVID-19 cases. | 2020-07-06 |
| 32623632 | SARS-Cov-2 infection causes significant liver injury in CLD patients, decompensating one fifth of cirrhosis, and worsening the clinical status of the already decompensated. | 2020-07-06 |
| 32623717 | Only 1% of patients developed COVID-19-related symptoms during the postoperative follow-up period. | 2020-07-06 |
| 32623723 | This literature overview provides a description of the clinical aspects of COVID-19 and its transmission, while supplying valuable information regarding protection and prevention measures. | 2020-07-06 |
| 32623810 | A large number of articles were published aiming to elaborate clinical characteristics and outcomes of pregnant women infected with Covid-19, in order to provide evidence for management. | 2020-07-06 |
| 32623831 | This is relevant information for the clinical management of patients in the setting of the current SARS-CoV-2 pandemic and potentially in risk-assessing staff interactions with infected patients. | 2020-07-06 |
| 32623963 | Accurate and early detection of infectious pathogens are crucial for transmission control, clinical diagnosis, and therapy. […] For a traditional reason, most immunological and microbiological laboratories are equipped with instruments designated for antibody-based assays in detection of infectious pathogens or clinical diagnosis. […] This review intends to summarize currently available aptamer-based technologies in detection of bacterial, viral, and protozoan pathogens for research and clinical application. […] It is anticipated that potential technologies will be further optimized and validated for clinical translation in meeting increasing demands for prompt, precise, and reliable detection of specific pathogens in various atmospheric conditions. | 2020-07-07 |
| 32624010 | The coronavirus disease 2019 pandemic has necessitated rapid adaptations to all levels of clinical practice. | 2020-07-07 |
| 32624037 | Doctors were more susceptible to moderate-to-severe depressive symptoms. […] The high-risk group had higher levels of clinical insomnia (13.5% v. […] 8.5%, p = 0.011) and were more likely to be in the upper quartile for stress symptoms (24.7% v. […] Additionally, work experience negatively correlated with insomnia symptoms. | 2020-07-07 |
| 32624076 | The epidemiological and clinical characteristics of the family cluster patients were analysed and compared with those of 43 contemporaneous sporadic cases. […] In terms of epidemiological characters and clinical symptoms, no significant differences were observed between the family cluster and sporadic cases. […] Within the family cluster, the second- and third-generation cases had milder clinical manifestations, without severe conditions, compared with the index and first-generation cases, indicating that the virulence gradually decreased following passage through generations within the family clusters. | 2020-07-07 |
| 32624085 | All visitors were assessed for body temperature and respiratory symptoms, and screened for recent overseas travel. […] All febrile patients with or without respiratory symptoms were taken to a respiratory safety clinic. | 2020-07-07 |
| 32624086 | A shift in the clinical approach to the ill child has occurred, the physical examination is problem-oriented, aiming to avoid un-necessary maneuvers and to minimize the number of practitioners involved. […] The most challenging aspects reported are: (1) performing a physical examination in personal protective equipment (PPE), (2) being updated with rapidly evolving guidelines, and (3) staying focused on the possible COVID-19 clinical presentation without failing in differential diagnosis. […] During the COVID-19 pandemic, it seems that pediatric emergency physicians are radically changing their clinical practice, aiming at prioritizing essential interventions and maneuvers and self-protection. | 2020-07-07 |
| 32624089 | Limited assessments with handheld ultrasound have found meaningful clinical use in the care of acutely ill patients. […] The purpose of this study was to assess the efficacy of limited handheld tablet echocardiography as an alternative to traditional echocardiography during the coronavirus disease 2019 (COVID-19) pandemic as a means to limit exposure while providing essential clinical information. […] Of these, 90 (99%) examinations were performed using a handheld device, and all were deemed diagnostic and provided sufficient information for the clinical care team. | 2020-07-07 |
| 32624257 | We discuss how the development of some symptoms in allergic rhinitis can serve as clues for new-onset COVID-19. […] Numerous clinical trials have been launched to identify effective treatments for COVID-19. | 2020-07-07 |
| 32624338 | One effect of the COVID-19 pandemic is the disruption of in-person clinical experiences within geriatric psychiatry residency education. | 2020-07-07 |
| 32624360 | Humans showing clinical symptoms of respiratory infections have been undergoing for the COVID-19 diagnostic test but many infected people and few pets confirmed with SARS-CoV-2 remained asymptomatic. | 2020-07-07 |
| 32624376 | Ayurvedic clinical profiling of COVID-19 is a pre-requisite to develop standalone and integrative treatment approaches. […] At present, Ayurvedic clinicians do not have access to COVID-19 patients in clinical settings. […] In these circumstances, a preliminary clinical profiling of COVID-19 based on review of modern medical and classical Ayurvedic literature with inputs from Allopathic clinicians treating COVID-19 patients assumes significance. […] This paper aims to develop an Ayurvedic clinical profile of COVID-19 by literature review supported by analysis of clinical data of a cohort of COVID-19 patients. […] The typical clinical presentation of COVID-19 was categorized based on a cluster of symptoms with reference to “Interim Clinical Guidance for Management of Patients with confirmed corona virus disease (COVID-19)” released by the US CDC. […] As the clinical presentation is found to vary widely, research papers reporting clinical symptoms of patient samples from different parts of the world were also reviewed to identify outliers and atypical presentations. […] Further, a careful correlation was done with the data collected from selected Ayurvedic classical texts and expert views of clinical practitioners to arrive at a preliminary Ayurvedic clinical profile of COVID-19. […] The asymptomatic, presymptomatic, mild, moderate, severe and critical stages of COVID-19 with varying clinical presentations have been analysed on the basis of nidāna, doṣa, dūṣya, nidānapañcaka and ṣaṭkriyākāla to present a preliminary clinical profile of the disease. […] In this paper, we have demonstrated that a preliminary clinical profiling of COVID-19 from the Ayurvedic perspective is possible through literature review supported by discussions with Allopathic clinicians as well as examination of patient case records. […] The provisional diagnosis proposed can be further developed with continued review of literature, wider cooperation and teamwork with Allopathic physicians and access to clinical data as well as direct clinical assessment of COVID-19 patients. | 2020-07-07 |
| 32624392 | Our experience (3 sessions with 14 participants) highlighted the difficult points of the procedure in the COVID-19 context, and defined a checklist for clinical practice and an assessment grid. | 2020-07-07 |
| 32624560 | Socio-demographic and clinical data, aspects of the event-exposure (date, place, length and distance of exposure, use of PPE) and details of the contact person were collected. | 2020-07-07 |
| 32624651 | The novel RNA betacoronavirus SARS-CoV-2 is driving great efforts in clinical and basic research and several studies of the epidemiology, risk factors, clinical and virological features of this infection are already available. | 2020-07-07 |
| 32624655 | Patients with COVID-19 usually manifest fever and respiratory symptoms. […] However, some patients also experience gastrointestinal (GI) symptoms such as diarrhea, vomiting and abdominal pain. […] In adult COVID-19 patients, the prevalence rates (95%CI) for all GI symptoms, and separately for diarrhea, nausea/vomiting, and abdominal discomfort/pain were 9.8% (6.4-14.7), 10.4% (95%CI 7.7-13.9), 7.7% (95%CI 4.8-12.1), and 6.9% (95%CI 3.9-11.9) respectively. […] The prevalence rates for children were 9.6% (95%CI 6.3-14.3) for all symptoms, 9.6% (95%CI 6.3-14.3) for diarrhea, and 6.8% (95% CI 4.2-11) for nausea/vomiting. […] A percentage of patients with COVID-19 will manifest symptoms from the digestive system. […] The GI tract may be a target organ and potential transmission route of SARS-CoV-2, with important implications for disease management and transmission. | 2020-07-07 |
| 32624690 | Based on clinical presentation, pathophysiology, high infectivity, high cardiovascular involvement, and therapeutic agents with cardiovascular toxicity of coronavirus disease 2019 (COVID-19), regular cardiovascular treatment is being changing greatly. | 2020-07-07 |
| 32625157 | The results reveal that more than a quarter of the participants have reported symptoms of depression (27.5%), anxiety (26.9%) and stress (26.5%) and as the time spent in lockdown has progressed, psychological symptoms have risen. | 2020-07-07 |
| 32625165 | In this review, we conduct a detailed summary for the potential of SARS-CoV-2 to infect central nervous system from latest biological fundamental of SARS-CoV-2 to the clinical experience of other human coronaviruses. | 2020-07-07 |
| 32625198 | However, in December 2019, a novel pneumonia condition termed coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with many clinical, epidemiological, and biological parallels to malaria, was reported in Wuhan, China. […] Likewise, the repurposing of antimalarials for treatment of COVID-19 shared symptoms and the shift in focus from the production of malaria rapid diagnostic tests (RDTs) to COVID-19 RDTs is a cause for concern in malaria-endemic regions. | 2020-07-07 |
| 32626554 | Considering the limitations of the study, the results should be interpreted with great caution and be viewed just as a preliminary report to motivate related basic and clinical researches. | 2020-07-07 |
| 32626666 | In order to evaluate the clinical utility, our RT-LAMP was subjected to a large number of clinical samples, including 213 negative and 47 positive patients, relative to two commercial quantitative RT-PCR assays. […] Subjecting our RT-LAMP assay to clinical samples showed a high degree of specificity (99.5%), sensitivity (91.4%), positive predictive value (97.7%), and negative predictive value (98.1%) when used relative to qRT-PCR. […] Conclusions: We present a rapid RT-LAMP assay that could extend the capacity of laboratories to process two times more clinical samples relative to qRT-PCR and potentially could be used for high-throughput screening purposes when demand is increasing at critical situations. | 2020-07-07 |
| 32626680 | Background: The clinical characteristics of coronavirus disease 2019 (COVID-19) have been well-studied, while effective predictors for clinical outcome and research on underlying mechanisms are scarce. […] Methods: Hospitalized COVID-19 pneumonia patients with definitive clinical outcome (cured or died) were retrospectively studied. […] Further, the correlations between leucocyte subsets and inflammation-related factors associated with clinical outcome were subsequently investigated. […] Lymphocyte subset (lymphocytes, T cells, helper T cells, suppressor T cells, natural killer cells, T cells+B cells+NK cells) counts were positively associated with clinical outcome (AUC: 0.777; AUC: 0.925; AUC: 0.900; AUC: 0.902; AUC: 0.877; AUC: 0.918, resp.). […] Conclusion: These results indicate that leucocyte subsets predict the clinical outcome of patients with COVID-19 pneumonia with high efficiency. | 2020-07-07 |
| 32626720 | Chinese Clinical Trial Registry, number: ChiCTR2000029883. | 2020-07-07 |
| 32626853 | Emerging reports suggest that new onset of smell or taste loss are potential early clinical markers of SARS-CoV-2 infection, but it remains unclear as to what extent. […] The loss of smell and taste preceded other symptoms in 20% of cases and it was concomitant in 28%. […] Based on this meta-analysis, we recommend self-isolation and testing, where possible, for patients complaining smell or taste impairment during COVID-19 pandemic in order to prevent spread of disease and propose the inclusion of loss of smell and taste as recognized symptoms of SARS-CoV-2 in the World Health Organization and other relevant regulatory body’s lists. | 2020-07-07 |
| 32626870 | The outbreak of COVID-19 poses a huge challenge to the implementation of various clinical researches including oral diseases. […] In view of the specialty of oral diseases, it is particularly necessary to protect the health and rights of the participators and related practitioners, and to standardize the implementation of clinical trials. […] Based on the normative standards issued by the National Health Commission of China, consensus on clinical trial management formulated by the organization of clinical research, and regulations for the diagnosis and treatment of oral diseases during public health emergencies by Chinese Stomatological Association, we drafted the guideline for clinical research of oral diseases, with a view to provide reference for the clinical studies of oral diseases under the first level response to major public health emergencies. | 2020-07-07 |
| 32626872 | In order to prevent and control the epidemic situation strictly, and to perform a scientific and orderly clinical diagnosis and treatment of dental emergency, this article provided suggestions on personnel management training, procedures and treatment, protection and disinfection of dental emergency during COVID-19 epidemic, and reference for dental institutions and medical staff. | 2020-07-07 |
| 32627059 | Gastrointestinal symptoms are common in COVID-19 patients, especially in younger patients. […] The higher intestinal ACE2 mRNA expression in older patients may impact on their susceptibility to develop intestinal symptoms. | 2020-07-07 |
| 32627126 | The classical clinical symptoms for SARS-CoV-2 affected patients are dry cough, high fever, dyspnoea, lethal pneumonia whereas many patients have also been found to be associated with a few additional signs and clinical manifestations of isolated vasculopathy. […] Albeit a deep and profound knowledge has been gained on the clinical features and management of COVID-19, less clear association has been provided on SARS-CoV-2 mediated direct or indirect vasculopathy and its possible correlation with disease prognosis. […] Besides, we debate the need of modulation in clinical approach from a hemodynamical point of view, as a measure towards reducing disease transmission, morbidity and mortality in SARS-CoV-2 affected patients. | 2020-07-07 |
| 32627127 | Currently, there is no robust clinical evidence for the use of these drugs in the treatment of COVID-19, with most, if not all of these medications associated with the potential for QT interval prolongation, torsades de pointes, and resultant drug-induced sudden cardiac death. | 2020-07-07 |
| 32627172 | In this paper, the theory from renewal process is partially adopted by considering the incubation period as the inter-arrival time, and the duration between departure from Wuhan and onset of symptoms as the mixture of forward time and inter-arrival time with censored intervals. | 2020-07-07 |
| 32627216 | Recovered COVID-19 patients, aged 18-55 years, who had experienced no symptoms for more than 2 weeks, were recruited. […] Whereas levels of N-specific IgM antibody declined after recovery, S-RBD-specific and N-specific IgG antibodies increased after 4 weeks from the onset of symptoms, with no significant correlation to age, sex, or ABO blood type. […] Of the 30 convalescent plasma donors, who had donated plasma later than 28 days after the onset of symptoms and had a disease presentation of fever lasting longer than 3 days or a body temperature exceeding 38.5°C, 100% had an S-RBD-specific IgG titer of ≥1:160 and 93% had a titer of ≥1:640. […] This study indicates that the S-RBD-specific IgG antibody reaches higher levels after 4 weeks from the onset of COVID-19 symptoms. […] We recommend the following selection criteria for optimal donation of COVID-19 convalescent plasma: 28 days after the onset of symptoms and with a disease presentation of fever lasting longer than 3 days or a body temperature exceeding 38.5°C. | 2020-07-07 |
| 32627255 | Research shows that the COVID Stress Scales have a robust multifactorial structure, representing five correlated facets of COVID-19-related distress: (a) Fear of the dangerousness of COVID-19, which includes fear of coming into contact with fomites potentially contaminated with SARSCoV2, (b) worry about socioeconomic costs of COVID-19 (e.g., worry about personal finances and disruption in the supply chain), (c) xenophobic fears that foreigners are spreading SARSCoV2, (d) traumatic stress symptoms associated with direct or vicarious traumatic exposure to COVID-19 (nightmares, intrusive thoughts, or images related to COVID-19), and (e) COVID-19-related compulsive checking and reassurance seeking. | 2020-07-07 |
| 32627299 | This article outlines the complex mechanistic and clinical interplay between diabetes and COVID-19, the clinical and research questions which arise from this relationship, and the types of studies needed to answer those questions. […] The authors are clinicians and academics working in diabetes and obesity medicine, but the article is pitched to an audience of generalists with clinical experience of or interest in the management of COVID-19. | 2020-07-07 |
| 32627319 | Here we describe the clinical characteristics, disease outcome, and risk factors for acute respiratory distress syndrome (ARDS) and death of a cohort of 53 kidney transplant patients with coronavirus disease 2019 (COVID-19). […] Because of severe symptoms, 45/53 required admission: this cohort has been managed with immunosuppression withdrawal, methylprednisolone 16 mg/d, hydroxychloroquine, and antiviral drugs. | 2020-07-07 |
| 32627434 | Due to the need for social distancing, the COVID-19 pandemic has temporarily reduced in-person visits for clinical care. […] Providers, clinical staff and patients are pressed to acutely learn new skills and adapt clinical care through the use of telemedicine whilst administrators, policy makers and regulatory organizations make changes to existing policies to meet this national emergency. | 2020-07-07 |
| 32627443 | Early screening of high-risk groups and taking action are the basics of disease management. | 2020-07-07 |
| 32627524 | These results might be useful for understanding the mechanism of cell entry, blood-brain barrier crossing, and clinical features related to the CNS infection by SARS-CoV-2. | 2020-07-07 |
| 32627606 | The results indicated that 12.8% of all participants with the symptoms of post-traumatic stress disorder and the effects of psychological distress on post-traumatic stress disorder was mediated by negative coping style. | 2020-07-07 |
| 32627689 | In the present study, we have chosen two clinical trial drugs against HIV-1 protease namely, TMB607 and TMC310911 to use as the inhibitors of SARS-CoV-2 main protease (Mpro) enzyme. | 2020-07-07 |
| 32628003 | Outcomes, including clinical improvement, mortality and changes in oxygen-support at 24, 48, and 72 hours, and 7, 14, and 28 days post-tocilizumab, are reported. […] Seven days after tocilizumab, ten patients (15.2%) had clinical improvement in their oxygenation status, and there was a 95% decrease in CRP. […] Within 14 days of treatment, 29% of patients had clinical improvement, 20% had minimal or no improvement, 17% worsened, 27% died, and 7% were transferred to an outside hospital. […] This study found limited clinical improvement in patients that received tocilizumab in the setting of severe COVID-19. […] Clinical trials are ongoing to further evaluate tocilizumab’s benefit in this patient population. | 2020-07-07 |
| 32628040 | Approach and Results: Medical records of 616 pneumonia patients who were admitted to the Yichang Central People’s Hospital in Hubei, China, from January 1 to March 23, 2020, were retrospectively reviewed. | 2020-07-07 |
| 32628127 | There are practical and ethical reasons for researchers not to neglect patient and public involvement (PPI), which has become an important cornerstone of UK-based clinical research. […] There has been a commendable effort towards driving evidence-based research, particularly through clinical trials in the UK. […] This article presents a brief background to PPI and points for consideration for clinical researchers currently active in or planning COVID-19 research. | 2020-07-07 |
| 32628222 | The unprecedented COVID-19 pandemic has risen a number of clinical situations where the principles of the medical act, the singularity of the patient-physician relationship and the need for revitalizing the medical vocation have all become at front line. | 2020-07-07 |
| 32628248 | Areas of management requiring clinical equipoise include agent selection and dosing, continuation vs interruption of home oral anticoagulant therapy during hospital admission, and postdischarge VTE prophylaxis. | 2020-07-07 |
| 32628270 | The most frequent clinical presentation (65%) was typical chilblains. […] In total, 93 cases (30%) showed clinical suspicion of COVID-19, 67 (22%) had only less specific infectious symptoms and 151 (49%) had no clinical signs preceding or during the course of acral lesions. […] Tested/untested patients or those with/without confirmed COVID-19 did not differ in age, sex, history or acral lesion clinical characteristics. | 2020-07-07 |
| 32628402 | Despite limited nonoperating room anaesthesia outcome data, analysis of malpractice claims, anaesthesia-related medical disputes and clinical outcome registries have suggested higher morbidity and mortality. | 2020-07-07 |
| 32628416 | The purpose of this review is to provide the current known clinical characteristics of and management for COVID-19 as it relates to otolaryngology. […] COVID-19 is a highly transmissible respiratory disease with common presenting symptoms of fever, cough, and fatigue. […] Maintaining appropriate preventive health measures and remaining updated on institutional clinical guidelines is paramount for both caretaker safety and patient care. | 2020-07-07 |
| 32628534 | The clinical utility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies remains undefined. […] To determine the clinical validity and utility of SARS-CoV-2 antibodies. […] Clinical record review was performed to classify them into a COVID-19 case group (n = 60) or a non-COVID-19 control group (n = 55). […] Antibodies to SARS-CoV-2 demonstrate infection when measured at least 14 days after symptom onset, are associated with clinical severity, and provide valuable diagnostic support in patients who test negative by NAAT but remain clinically suspicious for COVID-19. […] Clinical Immunology Laboratory, Department of Pathology, Johns Hopkins Hospital. | 2020-07-07 |
| 32628637 | The COVID-19 pandemic provides many scientific opportunities for clinical research and study of psychological and ethical issues in pregnant women. | 2020-07-07 |
| 32628638 | While non-urgent clinical services have been reduced as far as possible, all kind of specialists turned into COVID-19 specialists. […] In addition, as COVID-19 positive pregnant patients require additional care, some of the clinical habits need to be changed to face emerging needs for a vulnerable but unstoppable kind of patients. | 2020-07-07 |
| 32628642 | However, the relationship between antibody response and clinical outcomes has not been well described in this group. […] We conducted a single-center, retrospective, cohort study to investigate the relationship between serum immunoglobulin G (IgG) and IgM and clinical outcomes in severe/critical patients with COVID-19. […] The severe/critical patients with COVID-19 have a higher risk of clinical adverse events when IgM titer ≥ 50 AU/ml. | 2020-07-07 |
| 32628748 | We outline the limitations of HCTs and find that HCTs are likely to be most useful for vaccine candidates currently in preclinical stages of development. | 2020-07-07 |
| 32628750 | Only 11 (57.9%) of the 19 personnel with positive serology reported symptoms of a prior illness, suggesting asymptomatic healthcare personnel could be an important source of SARS-CoV-2 transmission. | 2020-07-07 |
| 32628793 | To describe the evolution of liver involvement during SARS-CoV-2 infection and its effect on clinical course and mortality. | 2020-07-07 |
| 32628899 | We propose that the cellular internalization of αvβ3 applies to uptake of coronaviruses bound to the integrin, and we evaluate the possibility that clinical host T4 may contribute to target cell uptake of coronavirus and to the consequence of cell uptake of the virus. | 2020-07-07 |
| 32628931 | The dynamics of viral load (VL) of the severe acute respiratory syndrome coronavirus 2 and its association with different clinical parameters remain poorly characterized in the US patient population. […] Herein, we investigate associations between VL and parameters, such as severity of symptoms, disposition (admission versus direct discharge), length of hospitalization, admission to the intensive care unit, length of oxygen support, and overall survival in 205 patients from a tertiary care center in New York City. […] Higher VL was associated with shorter duration of the symptoms in all patients and hospitalized patients only and shorter hospital stay (coefficient = -2.02, -2.61, and -2.18; P < 0.001, P = 0.002, and P = 0.013, respectively). | 2020-07-07 |
| 32628969 | In this axis, virus-induced inflammation and oxidative stress could be the common mechanisms responsible for CoV neurological symptoms. | 2020-07-07 |
| 32628976 | These data suggest that the ACE1 II genotype may influence the prevalence and clinical outcome of COVID-19 and serve as a predictive marker for COVID-19 risk and severity. | 2020-07-07 |
| 32628990 | Patients were screened for SARS-CoV-2 infection by symptoms and initial computed tomography (CT) of the chest. […] If patients developed symptoms after the initial screening was negative, repeat CT was performed. […] Morbidity, clinical features, and laboratory and radiologic findings. […] Half the SARS-CoV-2 infections in patients receiving MHD were subclinical and were not identified by universal CT of the chest and selective NAT. […] Serologic testing may help evaluate the overall prevalence and understand the diversity of clinical courses among patients receiving MHD who are infected with SARS-CoV-2. | 2020-07-07 |
| 32629042 | Anosmia is one of the most prevalent symptoms of SARS-CoV-2 infection during the COVID-19 pandemic. | 2020-07-07 |
| 32629100 | Lung recruitment detected by means of lung ultrasound is a relevant but not the exclusive mechanism that underlies the therapeutic efficacy of NI-CPAP in this clinical setting. | 2020-07-07 |
| 32629121 | While not an epidemiological tool for determining incidence, it can estimate the popularity of a certain disease by search volume over time.1,2 It has previously correlated well with infectious disease incidence and has demonstrated utility in disease forecasting, especially with influenza data.3 We utilized Google Trends to investigate whether search interest in common gastrointestinal (GI) symptoms would correlate with coronavirus disease 2019 (COVID-19) incidence data. | 2020-07-07 |
| 32629147 | To determine the frequency and severity of general and ear nose throat (ENT)- related symptoms, especially smell and/or loss of sense of taste (STL) in COVID-19 disease, as well as to investigate the recovery process of STL. […] Patients with a positive COVID-19 diagnosis were given a questionnaire consisting of general questions (age, sex, date of symptoms, smoking history, concomitant diseases), questions about the most obvious symptom at presentation (one option only), the severity and frequency of symptoms (general and ENT), and STL (recovery time and degree of recovery). […] Cough (n = 30, 17.4%) and loss of sense of smell (n = 18, 10.4%) were the most obvious general and ENT symptoms, respectively. […] The loss of sense of smell and loss of sense of taste were the unique symptoms in four (4.54%) and one (1.23%) patients, respectively. | 2020-07-07 |
| 32629149 | Chloroquine (CQ) and its analogue hydroxychloroquine (HCQ) have been thrust into our everyday vernacular because some believe, based on very limited basic and clinical data, that they might be helpful in preventing and/or lessening the severity of the pandemic coronavirus disease 2019 (COVID-19). | 2020-07-07 |
| 32629169 | Although it is largely preclinical data that suggest the potential of CQ, properly planned prophylactic trials and further research are urgently needed. | 2020-07-07 |
| 32629280 | The review also focuses on the listing of drugs that are currently testing under clinical trials for the COVID-19 virus with their mechanism of action. | 2020-07-07 |
| 32629402 | Whilst limited, the cautiously reassuring nature of these early cases assisted in clinical management by allowing neurologists to continuously reassess their approach to DMT management. | 2020-07-07 |
| 32629424 | Prior to the outbreak of coronavirus disease (COVID-19), telemental health to support mental health services was primarily designed for individuals with professional clinical degrees, such as psychologists, psychiatrists, registered nurses, and licensed clinical social workers. | 2020-07-07 |
| 32629425 | The following parameters of COVID-19 were reported daily: signs/symptoms; diagnosis by reverse transcriptase-polymerase chain reaction; absence of symptoms for ≥14 days; total deaths; and number of health care workers isolated with suspected COVID-19. | 2020-07-07 |
| 32629518 | Due to the central role of the adrenals in the stress response of the organism, this finding is of potential clinical relevance, because infection with the SARS-CoV-2 virus might critically impair adrenal function under pathophysiological conditions. | 2020-07-07 |
| 32629531 | The selective JAK1/2 inhibitor ruxolitinib has shown promising results in the context of GVHD, and different trials are currently underway in patients with severe COVID-19; nevertheless, no clinical observation of safety or efficacy of treatment with ruxolitinib in this context has been published yet. | 2020-07-07 |
| 32629642 | Studies by registers of clinical trials will be additionally searched. […] Our study will provide a reference foundation for clinical optimization of treatment. | 2020-07-08 |
| 32629703 | In this report, we discuss the case of a hemodialysis patient who developed COVID-19 pneumonia in the clinical course. | 2020-07-08 |
| 32629768 | We searched PubMed to identify all relevant clinical and laboratory studies published up to 15 May 2020; the guidelines on the use of LPV/r in COVID-19 were further directly searched on the website of the main international scientific societies and agencies. […] In our opinion, despite the controversial results of an important randomized clinical trial, and some recommendations, clinicians should not abandon the use of LPV/r for the treatment of COVID-19, possibly using this drug inside a prospective randomized trial, waiting for the results of the numerous ongoing trials evaluating its efficacy. | 2020-07-08 |
| 32629788 | The aim of our study was to evaluate the clinical course of COVID-19 in this setting. […] The clinical course of COVID-19 patients on CNIs is generally mild, and the risk of superinfection seems low. | 2020-07-08 |
| 32629804 | In early research, the targeted antivirals remdesivir and favipiravir appear to benefit patients by decreasing viral replication; clinical trials suggest that remdesivir speeds recovery from COVID-19. | 2020-07-08 |
| 32629817 | Hopefully these findings can drive future drug development and clinical procedures. | 2020-07-08 |
| 32629875 | Recently, new clinical syndromes associated with coagulopathy and vasculopathy have emerged as a cause of sudden death and other serious clinical manifestations in younger patients infected with SARS-CoV-2 infection. | 2020-07-08 |
| 32629915 | 71.2% of dentists who responded to the questionnaire decided to suspend their clinical practice during that particular time. […] Due to the unpreparedness of the dental sector, both in national health and private settings, most of the Polish dentists decided to voluntarily suspend their clinical practice in order to mitigate the spread of the disease. | 2020-07-08 |
| 32629963 | This study used the WHO guidelines and Design Science Research (DSR) framework to redesign the Portable Health Clinic (PHC), an RHS, for the containment of the spread of COVID-19 as well as proposed corona logic (C-Logic) for the main symptoms of COVID-19. | 2020-07-08 |
| 32629995 | PADI isozyme 1-6 expression in other organ biopsies also reveals putative links to COVID-19 symptoms, including vascular, cardiac and cutaneous responses, kidney injury and stroke. | 2020-07-08 |
| 32630111 | Co-infections have an unknown impact on the morbidity and mortality of the new clinical syndrome called coronavirus disease 2019 (COVID-19). | 2020-07-08 |
| 32630212 | The clinical presentation of MIS-C includes fever, severe illness, and the involvement of two or more organ systems, in combination with laboratory evidence of inflammation and laboratory or epidemiologic evidence of SARS-CoV-2 infection. […] Patients with MIS-C should ideally be managed in a pediatric intensive care environment since rapid clinical deterioration may occur. […] Specific immunomodulatory therapy depends on the clinical presentation. | 2020-07-08 |
| 32630601 | We demonstrated that combining two single systems into a dual-target assay (with or without an MS2-based internal control) did not impair performances, providing a potent tool adapted for routine molecular diagnosis in clinical microbiology laboratories. | 2020-07-08 |
| 32630735 | The aim of this paper is to provide practical advice for dentists based on the recent literature, which may be useful in reducing the risk of spreading COVID-19 during clinical practice. | 2020-07-08 |
| 32630746 | Considerable scientific progress was recorded regarding SARS-CoV-2 infection in terms of genomic structure, diagnostic tools, viral transmission, mechanism of viral infection, symptomatology, clinical impact, and complications, but these data evolve constantly. […] Up to date, neither an effective vaccine nor SARS-CoV-2 specific antiviral agents have been approved, but significant advances were enlisted in this direction by investigating repurposed approved drugs (ongoing clinical trials) or developing innovative antiviral drugs (preclinical and clinical studies). […] In addition, a comprehensible overview of SARS-CoV-2 infection in terms of general description and structure, mechanism of viral infection, and clinical impact was portrayed. | 2020-07-08 |
| 32630821 | Since quarantine can impact on mental health, this study aimed to estimate the prevalence of depressive symptoms, anxiety symptoms and sleeping disturbances in the Italian population during lockdown. | 2020-07-08 |
| 32631130 | This study aimed to evaluate the feasibility and clinical utility of training intensive psychiatric community care team members to serve as “mobile interventionists” who engage patients in recovery-oriented texting exchanges. […] Clinical outcomes were evaluated at baseline, posttreatment, and 6-month follow-up, and satisfaction was evaluated posttreatment. […] Exploratory posttreatment clinical effect estimations suggested greater reductions in the severity of paranoid thoughts (Cohen’s d=-0.61) and depression (d=-0.59) and improved illness management (d=0.31) and recovery (d=0.23) in the mobile interventionist group. | 2020-07-08 |
| 32631317 | The evaluation of clinical response to therapy was based on chest CT scan. […] Serum LDH was validated for its potential usefulness as markers for evaluating clinical severity and monitoring treatment response in COVID-19 pneumonia. | 2020-07-08 |
| 32631393 | However, the clinical course, and the 60-day mortality and its predictors in critically ill patients have not been fully elucidated. […] The aim of this study is to identify the clinical course, and 60-day mortality and its predictors in critically ill patients with COVID-19. […] Data on demographic information, preexisting comorbidities, laboratory findings at ICU admission, treatments, clinical outcomes, and results of SARS-CoV-2 RNA tests and of serum SARS-CoV-2 IgM were collected including the duration between symptom onset and negative conversion of SARS-CoV-2 RNA. | 2020-07-08 |
| 32631405 | This study is a randomized, single-blinded, two-arm (1:1 ratio) parallel group clinical trial. […] The inclusion criteria are as follows: (1) aged between 20 and 60 years, (2) both male and female patients with COVID-19, (3) clinical or definitive diagnosis (using polymerase chain reaction (PCR) test), (4) patients have not participated in other clinical trials, and (5) no renal or hepatic abnormalities. […] The Iranian Registry of Clinical Trials IRCT20200319046819N1 . | 2020-07-08 |
| 32631442 | Since the outbreak of coronavirus disease 2019 (COVID-19), many researchers in China have performed related clinical research. […] However, systematic reviews of the registered clinical trials are still lacking. […] Therefore, we conducted a systematic review of clinical trials for COVID-19 to summarize their characteristics. […] The Chinese Clinical Registration Center and the ClinicalTrials.gov databases were searched to identify registered clinical trials related to COVID-19. […] A total of 75 registered clinical trials (63 interventional studies and 12 observational studies) for COVID-19 were identified. […] The majority of clinical trials were sponsored by Chinese hospitals. […] Only 11 trials have begun to recruit patients, and none of the registered clinical trials have been completed; 34 trials were early clinical exploratory trials or in the pre-experiment stage, 13 trials were phase III, and four trials were phase IV. […] The main outcomes were clinical observation and examinations. […] Intensive clinical trials on the treatment of COVID-19 using traditional Chinese medicine and Western medicine are ongoing or will be performed in China. […] However, based on the uncertain methodological quality, small sample size, and long trial duration, we will not be able to obtain reliable, high-quality clinical evidence regarding the treatment of COVID-19 in the near future. […] Improving the quality of study design, prioritizing promising drugs, and using different designs and statistical methods are worth advocating and recommending for clinical trials of COVID-19 in the future. | 2020-07-08 |
| 32631470 | We report a family cluster of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection involving five patients in a family cluster in Dazhou, China, including the epidemiological, clinical, laboratory and radiological findings. | 2020-07-08 |
| 32631575 | Over the past two decades, since the Severe Acute Respiratory Syndrome (SARS) outbreak, a large body of research has accumulated on the virology, clinical symptoms and signs, and experimental treatments of Coronaviruses. […] Given the wide-ranging clinical presentations of those infected with SARS-CoV-2, other viruses might be overlooked when evaluating at-risk patients. […] Furthermore, due to suboptimal testing capabilities, an early clinical diagnosis is not always possible. | 2020-07-08 |
| 32631626 | Chest radiographs from 50 patients with COVID-19, and 50 control patients with symptoms consistent with COVID-19 from prior to the emergence of the novel coronavirus were assessed by seven consultant radiologists with regards to the British Society of Thoracic Imaging guidelines. | 2020-07-08 |
| 32631687 | This general review firstly provides a better understanding of the virus responsible for the pandemic: the SARS-CoV-2, and the clinical manifestations of the COVID-19 disease. […] The second part is detailing the pathophysiology, clinical signs and challenges of ocular involvement, which seems rare and not functionally severe, but which may be a potential source of contamination. | 2020-07-08 |
| 32631736 | The patient who continued iguratimod therapy without dose reduction was treated with ciclesonide had an uneventful clinical course, but prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was observed after resolution of symptoms. […] The effects of disease-modifying antirheumatic drugs (DMARDs) and ciclesonide on clinical course and viral shedding remain unknown and warrant further investigation. | 2020-07-08 |
| 32631771 | She was treated for Kawasaki Disease Shock Syndrome (KDSS) with pulse dose solumedrol, IVIG, and aspirin with near resolution of symptoms and normalization of vital signs within 1 day and subsequent improvement in her laboratory abnormalities. […] Our understanding of the myriad of COVID-19 symptoms and sequelae is rapidly evolving. | 2020-07-08 |
| 32632198 | We reviewed relevant literature to understand the clinical course of disease and transmission routes in affected neonates. […] The aim of the study was evaluating the clinical course and prognosis of SARS-CoV-2 positive neonates. […] Main symptoms were fever, cough, or shortness of breath but often these neonates did not show other symptoms during length stay in hospital. | 2020-07-08 |
| 32632355 | In the present case series, we have attempted to summarize their clinical profile, changes in laboratory biomarkers and outcomes. | 2020-07-08 |
| 32632359 | Therefore, early treatment with anti-oxidants such as NAC during COVID-19 can be a way to bypass the excessive inflammation and cell damage that lead to severe infection, thus early NAC as intervention should be evaluated in a clinical trial setting. | 2020-07-08 |
| 32632379 | The second (optional) part of the questionnaire was the validated Hospital Anxiety and Depression Scale (HADS), a self-reported measure used to assess levels of anxiety and depressive symptoms. […] The impact on perceived productivity, with 71.2% of participants feeling less productive, caused 58% of participants to feel some level of guilt.Compared to normative data, relatively high levels of anxiety and depressive symptoms were recorded for the 335 participants who filled out the HADS questionnaire. | 2020-07-08 |
| 32632380 | The clinical signs of coronavirus disease-19 (COVID-19) can be heterogenous because of the diversity of potential organ involvement. | 2020-07-08 |
| 32632416 | We performed a systematic review to assess whether ethnicity has been reported in patients with COVID-19 and its relation to clinical outcomes. […] We also reviewed: COVID-19 articles in NEJM, Lancet, BMJ, JAMA, clinical trial protocols, grey literature, surveillance data and preprint articles on COVID-19 in MedRxiv to evaluate if the association between ethnicity and clinical outcomes were reported and what they showed. […] Of 209 preprints, 34 reported ethnicity - 13 found Black, Asian and Minority Ethnic (BAME) individuals had an increased risk of infection with SARS-CoV-2 and 12 reported worse clinical outcomes, including ITU admission and mortality, in BAME patients compared to White patients. […] Of 12 grey literature reports, seven with original data reported poorer clinical outcomes in BAME groups compared to White groups. […] However, emerging data from the grey literature and preprint articles suggest BAME individuals are at an increased risk of acquiring SARS-CoV-2 infection compared to White individuals and also worse clinical outcomes from COVID-19. | 2020-07-08 |
| 32632635 | Data sources were the clinical reports of patients admitted during the first month of lockdown and discharged with a confirmed diagnosis of stroke or TIA. […] As controls, we evaluated the clinical reports of patients with stroke or TIA admitted in the same period of 2019. […] The clinical reports of patients eligible for the study were 52 in 2020 (71.6 ± 12.2 years) and 41 in 2019 (73.7 ± 13.1 years). | 2020-07-08 |
| 32632645 | Most of the participants knew the term COVID-19 and its mode of transmission (90%), signs and symptoms (84%) and risk factors (72%) associated with it. […] Ninety percent of the respondents were avoiding close contact with the people having cough and flu-like symptoms. | 2020-07-08 |
| 32632766 | More than 1,200 active or recruiting clinical trials for novel coronavirus disease 2019 (COVID-19) treatments and vaccines are registered. […] The drawbacks of these trials include exposing the patients to drugs with well-documented systemic adverse effects or unknown complications of novel therapies without proof of clinical benefit. […] The concept of this idea has many uncertainties and no current clinical data to support. | 2020-07-08 |
| 32632917 | None of the patients reported symptoms of coronavirus infection. | 2020-07-08 |
| 32632947 | The possible causes and potential clinical significance of this phenomenon are discussed. | 2020-07-08 |
| 32632960 | Progresses on the development of potential therapeutics and vaccines that are under the preclinical studies and clinical trials have been highlighted. | 2020-07-08 |
| 32633068 | We performed a systematic screening for the diagnosis of deep vein thrombosis (DVT) by lower limb vein compression ultrasonography (CUS) in consecutive non-ICU patients hospitalized for COVID-19, independent of the presence of signs or symptoms of DVT. | 2020-07-08 |
| 32633162 | We describe the case of a 42 year old, healthy patient with Covid-19 who despite improvement in his respiratory symptoms developed a mild to moderate cytokine release syndrome (CRS) and an associated monoarticular gout flare. | 2020-07-08 |
| 32633235 | Dysfunction of the RAS has been observed in COVID-19 patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type-1 receptor blockers (ARBs), are associated with improved or worse clinical outcomes, remains unclear. | 2020-07-08 |
| 32633236 | COVID-19 causes in some patients typical symptoms of enteritis such as diarrhea or abdominal pain. | 2020-07-08 |
| 32633327 | COVID-19 and its two predecessors share many important features in their clinical presentations, and in their propensity for progression to severe disease which is marked by high rates of morbidity and mortality. […] However, comparison of the three viral illnesses also reveals a number of specific differences in clinical manifestations and complications, which suggest variability in the disease process. | 2020-07-08 |
| 32633410 | This disease is currently diagnosed by clinical features, chest computed tomography (CT) scan, and nucleic acid test of severe acute respiratory syndrome coronavirus (SARS-CoV-2). […] These findings revealed that the body temperature and clinical laboratory test all returned to normal after this patient received a prolonged treatment. | 2020-07-08 |
| 32633414 | The rise in the number of infected patients and deaths is of great concern especially because symptoms are vague and similar to other forms of flu infection and corona syndrome infections characterized by fever, fatigue, dry cough, and dyspnea. | 2020-07-08 |
| 32633464 | The questionnaire included demographic information and ascertained psychological distress, anxiety and depressive symptoms, and risk and protective factors. | 2020-07-08 |
| 32633594 | Moreover, in the present study we investigated the effects of angiotensin-converting enzyme inhibitor versus angiotensin receptor blockers versus calcium channel blockers on clinical outcomes as mechanical ventilation, intensive care unit admissions, heart injury, and death in 62 patients with hypertension hospitalized for COVID-19 infection. […] Consequently, tailored anti-inflammatory and immune therapies in addition to chronic antihypertensive therapy, could prevent a worse prognosis, as well as improve the clinical outcomes in patients with hypertension with COVID-19 infection. | 2020-07-08 |
| 32633678 | As per the Fleischner Society consensus statement, CT is appropriate in certain scenarios, including patients who are at risk for and/or develop clinical worsening. | 2020-07-08 |
| 32633712 | Clinical and laboratory evaluation of SARS-CoV-2-positive pregnant women at the time of diagnosis can identify patients at risk for ICU hospitalization. | 2020-07-08 |
| 32633718 | These bradykinin-driven outcomes explain many of the symptoms being observed in COVID-19. | 2020-07-08 |
| 32633720 | Understanding temporal dynamics of COVID-19 symptoms could provide fine-grained resolution to guide clinical decision-making. […] Here, we use deep neural networks over an institution-wide platform for the augmented curation of clinical notes from 77,167 patients subjected to COVID-19 PCR testing. […] By contrasting Electronic Health Record (EHR)-derived symptoms of COVID-19-positive (COVIDpos ; n = 2,317) versus COVID-19-negative (COVIDneg ; n = 74,850) patients for the week preceding the PCR testing date, we identify anosmia/dysgeusia (27.1-fold), fever/chills (2.6-fold), respiratory difficulty (2.2-fold), cough (2.2-fold), myalgia/arthralgia (2-fold), and diarrhea (1.4-fold) as significantly amplified in COVIDpos over COVIDneg patients. | 2020-07-08 |
| 32633770 | Relegated to clinical afterthought, the topic of infection control has never taken center stage in our modern dental sedation and anesthesiology practices. | 2020-07-08 |
| 32633809 | Creative solutions have now replaced the clinical training that normally takes place during the students’ clinical education at the hospital. | 2020-07-08 |
| 32633816 | The Covid-19 crisis has underscored the importance of the collection and analysis of clinical and research data and specimens for ongoing work. | 2020-07-08 |
| 32633856 | Symptoms such as fever or cough, and signs such as oxygen saturation or lung auscultation findings, are the first and most readily available diagnostic information. […] To assess the diagnostic accuracy of signs and symptoms to determine if a person presenting in primary care or to hospital outpatient settings, such as the emergency department or dedicated COVID-19 clinics, has COVID-19 disease or COVID-19 pneumonia. […] All signs and symptoms were eligible for this review, including individual signs and symptoms or combinations. […] We accepted a range of reference standards including reverse transcription polymerase chain reaction (RT-PCR), clinical expertise, imaging, serology tests and World Health Organization (WHO) or other definitions of COVID-19. […] We found data on 27 signs and symptoms, which fall into four different categories: systemic, respiratory, gastrointestinal and cardiovascular. […] No studies assessed combinations of different signs and symptoms and results were highly variable across studies. […] Most had very low sensitivity and high specificity; only six symptoms had a sensitivity of at least 50% in at least one study: cough, sore throat, fever, myalgia or arthralgia, fatigue, and headache. […] Seven studies carried a high risk of bias for selection of participants because inclusion in the studies depended on the applicable testing and referral protocols, which included many of the signs and symptoms under study in this review. […] These factors make it very difficult to determine the diagnostic properties of these signs and symptoms from the included studies. […] We hope that future updates of this review will be able to provide more information about the diagnostic properties of signs and symptoms in different settings and age groups. […] The individual signs and symptoms included in this review appear to have very poor diagnostic properties, although this should be interpreted in the context of selection bias and heterogeneity between studies. […] Based on currently available data, neither absence nor presence of signs or symptoms are accurate enough to rule in or rule out disease. […] Prospective studies in an unselected population presenting to primary care or hospital outpatient settings, examining combinations of signs and symptoms to evaluate the syndromic presentation of COVID-19 disease, are urgently needed. […] We also need data on potentially more specific symptoms such as loss of sense of smell. | 2020-07-08 |
| 32633869 | Similar to the course of the disease in non pregnant adults, 80% to 90% of infections were not severe.The prevalence of reported symptoms was four-fold higher in SARS-CoV-2 positive patients (57%) than in those negative (13%) (P < .001), suggesting that direct self-testing should open doors to confirmatory testing for COVID-19. | 2020-07-08 |
| 32633997 | Currently, available data indicate that the majority of people with the disease have mild symptoms, while about 20% present with moderate-to-severe disease. | 2020-07-08 |
| 32634004 | Measures adopted by FPs across the country in the fight against the scourge include triaging patients as they present to the family medicine clinics; health education and enlightenment of the populace; and ensuring social distancing, regular handwashing and compulsory use of face mask by both physicians and patients during clinical consultations. | 2020-07-08 |
| 32634024 | Clinical trials of treatments for coronavirus disease 2019 (COVID-19) draw intense public attention. […] Clinical investigators are encouraged to consider applying these methods for quantifying treatment effects in future studies of COVID-19. | 2020-07-08 |
| 32634029 | The secondary aims were to determine whether: 1) there were clinical predictors of COVID-19 status; and 2) whether social lockdown influenced the incidence and epidemiology of hip fractures. […] Only seven (26%) had suggestive symptoms on admission. […] Notably, most patients with hip fracture and COVID-19 lacked suggestive symptoms at presentation. | 2020-07-08 |
| 32634067 | The COVID-19 pandemic has required oncologists to redefine clinical organization and patient management. […] Impressively, a total of 357 (93%) participants declared the oncologic department reorganized routine clinical activity, but only 40.5% were adequately trained about the required procedures; 20% of the survey respondents think they have not received adequate and timely protective devices. | 2020-07-08 |
| 32634079 | Based on its effects on the modulation of the autophagy process, various clinical studies suggest that CQ and HCQ could be used in combination with other chemotherapeutics for the treatment of various types of cancer. | 2020-07-08 |
| 32634080 | The clinical severity and extent of transmission need to be determined, and therapeutic options need to be developed and optimized. […] Although some evidence indicates the positive actions of different classes of compounds for the treatment of COVID-19, few clinical assays have been established to definitively demonstrate their therapeutic value in humans. […] Multicenter clinical studies are urgently needed to validate and standardize therapeutic regimens that involve these agents. | 2020-07-08 |
| 32634105 | In severe cases, there may be symptoms of psychosis or posttraumatic stress disorder. […] Implications to clinical practices, psychological therapeutic practices, and future research directions to address current effort gaps are highlighted in this study. | 2020-07-08 |
| 32634106 | The clinical care process will be described, including accessing the telehealth platform, assessment during the initial appointment, injury management including communication with relevant patient stakeholders (eg, parent or guardians, athletic trainers), dissemination of rehabilitation exercises, and nature of follow-up visits. | 2020-07-08 |
| 32634129 | Serial clinical samples were collected for laboratory detection. | 2020-07-08 |
| 32634229 | During the current global pandemic of COVID-19 (coronavirus disease 2019), multiple assays with unknown clinical sensitivity and specificity have been rapidly developed to aid in the diagnosis of the disease. […] Hence, using this situation as an clinical example, the goal of this article is to clarify the key factors that influence the PPV and NPV yielded by diagnostic testing, By doing so, we hope to offer health-care providers information that will help them better understand the potential implications of utilizing these test results in clinical patient management. | 2020-07-08 |
| 32634438 | The high rate and volume of emerging clinical trials on therapies for COVID-19 need to be compared and evaluated to provide scientific evidence for effective medical options. […] This review describes the proposed drug targets for therapy, and outcomes of clinical trials that have been reported. | 2020-07-08 |
| 32634459 | This systematic review compares mortality risk factors including clinical, demographic and laboratory features of COVID-19, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). | 2020-07-08 |
| 32634536 | Data reviewed in this study included (1) length of time from detectable to undetectable results; (2) length of time from onset of symptoms to undetectable result; (3) length of time from resolution of fever to undetectable result. […] The mean time for onset of symptoms to undetectable testing was 21.5 days. | 2020-07-08 |
| 32634585 | The electronic medical records were reviewed. […] Data including demographic characteristics, clinical manifestations, comorbidities, laboratory data, and radiological examinations of 435 hospitalized COVID-19 patients with a confirmed SARS-CoV-2 viral infection were extracted and analyzed retrospectively. | 2020-07-08 |
| 32634587 | Eleven (42%) of them had symptoms typical for COVID-19, during the study period. | 2020-07-08 |
| 32634589 | However, its curative effects and feasibility have yet to be confirmed by formal evaluation and well-designed clinical trials. […] The sources of clinical and methodological heterogeneity were identified. | 2020-07-08 |
| 32634603 | China’s National Health Commission has issued the first COVID-19 treatment guidelines with therapy suggestions, which has inspired clinical studies worldwide. […] Key evidence from in vitro research, animal models and clinical research in emerging coronaviruses is examined. […] Chloroquine and hydroxychloroquine have shown in vitro inhibition of SARS-CoV-2, but studies on their clinical efficacy and whether the benefits outweigh the risk of dysrhythmias remain inconclusive. | 2020-07-08 |
| 32634716 | PubMed, Cochrane Central Register of Clinical Trials were searched on April 28, 2020, to extract published articles that reported the outcomes of COVID-19 patients. […] The search terms were “coronavirus” and “clinical characteristics”. | 2020-07-08 |
| 32634813 | The patient arrived 1 h after onset of symptoms, was treated with recombinant tissue plasminogen activator (rtPA) with improvement of neurologic deficits, and later developed right foot arterial ischemia (recanalized by balloon catheter angioplasty) and left arm superficial venous thrombosis. | 2020-07-08 |
| 32634818 | Fewer children than adults have been affected by the COVID-19 pandemic, and the clinical manifestations are distinct from those of adults. | 2020-07-08 |
| 32634819 | The aim of this consensus statement is to define guidelines for safe clinical care for children needing inter-facility transport while making sure that the clinical teams involved are sufficiently protected from SARS-CoV-2. […] A taskforce, composed of members of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC) Transport section and the European Society for Paediatric Research (ESPR), reviewed the published literature and used a rapid, two-step modified Delphi process to formulate recommendations regarding safety and clinical management during transport of COVID-19 patients. | 2020-07-08 |
| 32634823 | Internationally, key workers such as healthcare staff are advised to stay at home if they or household members experience coronavirus disease 2019 (COVID-19)-like symptoms. […] We used a decision-analytic model for 1,000 key workers to compare the baseline strategy of (S0) no RT-PCR testing of workers to testing workers (S1) with COVID-19-like symptoms in isolation, (S2) without COVID-19-like symptoms but in household-quarantine, and (S3) all staff. | 2020-07-08 |
| 32634826 | Air and surface samples were collected from seven clinical areas, occupied by patients with COVID-19, and a public area of the hospital. […] The proportion of surface samples contaminated with viral RNA varied by item sampled and by clinical area. | 2020-07-08 |
| 32634830 | As the coronavirus disease 2019 (COVID-19) outbreak accelerates worldwide, it is highly significant to evaluate sex-specific clinical characteristics and outcomes, that may affect public health policies. […] Clinical features, laboratory data, complications and outcomes were compared between females and males. […] Compared with males, more females had no initial symptoms (11.1% vs 8.3%, p=0.008). | 2020-07-08 |
| 32634855 | Clinical data were retrospectively collected and analyzed. […] However, the elderly patients manifested minor clinical symptoms and atypical changes in chest CT images, which usually lead to misdiagnosis or delayed diagnosis. | 2020-07-08 |
| 32635290 | Additionally, patients’ electronic medical records were reviewed along with closed-circuit television (CCTV) recordings. | 2020-07-09 |
| 32635302 | Severity of infection varies from complete absence of symptomatology to more aggressive symptoms, characterized by sudden acute respiratory distress syndrome (ARDS), multiorgan failure, and sepsis, requiring treatment in intensive care unit (ICU). | 2020-07-09 |
| 32635353 | The patient subsequently experienced marked improvements in his respiratory symptoms and overall clinical status over the following days. […] We believe that tocilizumab played a substantial role in his ability to avert clinical decline, particularly the need for mechanical ventilation. […] This case underscores the potential importance of early serial measurements of IL-6 and cytokine storm-associated acute phase reactants, such as ferritin, D-dimer, and C-reactive protein, in guiding clinical decision-making in the management of patients with suspected COVID-19. | 2020-07-09 |
| 32635468 | Frailty may have contributed to the vulnerability of older people to more severe clinical presentation. […] Forty papers were included: 13 editorials, 15 recommendations/guidelines, 3 reviews, 1 clinical trial, 6 observational studies, 2 case reports. […] Editorials and reviews underlined the potential clinical relevance of assessing frailty among older patients with COVID-19. […] Even with such limited evidence, clinical recommendations on the use of frailty tools have been proposed to support decision making about escalation plan. | 2020-07-09 |
| 32635775 | The most common symptoms presented were fever (55%), cough (38%) and fatigue (11%). | 2020-07-09 |
| 32635935 | The anti-polymerase drugs predicted here-CID123624208 and CID11687749-may be considered for in vitro and in vivo clinical trials. | 2020-07-09 |
| 32636061 | Demographics, comorbidities, symptoms, laboratory findings, treatments and outcomes of COVID-19 patients with diabetes were collected and analyzed. | 2020-07-09 |
| 32636075 | For patients with suspected infections, reliable epidemiological information and clinical symptoms, clinical management is necessary even when the chest CT is negative. | 2020-07-09 |
| 32636114 | Even though there are clinical trials on the development of therapeutics and vaccines, there are currently no licensed vaccines or therapeutics for COVID-19. | 2020-07-09 |
| 32636116 | Children show a variable clinical course of COVID-19, from asymptomatic to critical. | 2020-07-09 |
| 32636210 | Data on the clinical presentation of the infection in children are limited. […] We present clinical data from 22 patients and highlight the variability of the presentation. […] In our study, most children presented without respiratory illness or symptoms suggestive of COVID-19; many were identified only because of universal testing. […] Because children may have variable signs and symptoms of COVID-19 infection, targeted testing may miss some cases. | 2020-07-09 |
| 32636214 | The clinical performances of six molecular diagnostic tests and a rapid antigen test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were clinically evaluated for the diagnosis of coronavirus disease 2019 (COVID-19) in self-collected saliva. […] Viral RNA was detected at significantly higher percentages (65.6 to 93.4%) in specimens collected within 9 days of symptom onset than in specimens collected after at least 10 days of symptoms (22.2 to 66.7%) and in specimens collected from asymptomatic patients (40.0 to 66.7%). […] The RT-qPCR LDT, a cobas SARS-CoV-2 high-throughput system, direct RT-qPCR kits (except for one commercial kit), and RT-LAMP showed sufficient sensitivities in clinical use to be selectively used in clinical settings and facilities. | 2020-07-09 |
| 32636454 | SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases, with a mortality rate of ~6.4% worldwide (based on World Health Organization daily situation report). | 2020-07-09 |
| 32636542 | A positive real-time reverse-transcriptase polymerase chain reaction (RT-PCR), in conjunction with clinical and epidemiologic data, is the current standard for diagnosis, but several challenges still exist. […] We provide a narrative review of peer-reviewed research studies on RT-PCR, serology and antigen immune-assays for COVID-19, briefly describe their lab methods and discuss their limitations for clinical practice. | 2020-07-09 |
| 32636686 | The aim of this review was to describe the current knowledge about coronavirus disease 2019 (COVID-19, which is caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) in children, from epidemiological, clinical, and laboratory perspectives, including knowledge on the disease course, treatment, and prognosis. […] Clinical signs and symptoms are comparable to those in adults, but milder forms and a large percentage of asymptomatic carriers are found among children. […] This review highlights that COVID-19 in children is similar to the disease in the adult population, but with particularities regarding clinical manifestations, laboratory test results, chest imaging, and treatment. | 2020-07-09 |
| 32636699 | Transmission of the disease by airborne route was well known by the participants (91.1%), as well as the main symptoms such as fever (92.4%), cough (84.4%), and dyspnea (60.3%). | 2020-07-09 |
| 32636754 | In this review, we focus on the latest developments in COVID-19 vaccine development, including results of the first Phase I clinical trials and describe a number of the early candidates that are emerging in the field. | 2020-07-09 |
| 32636919 | The goal of this narrative review is to evaluate current and ongoing clinical trials of vitamins and supplements, alone or in combination with each other or other therapies, for the treatment of coronavirus disease-2019 (COVID-19). | 2020-07-09 |
| 32637059 | However, the hypothesis that nicotine may have a protective effect in COVID-19 that is partially masked by smoking-related toxicity and by the abrupt cessation of nicotine intake when smokers are hospitalized should be explored in laboratory studies and clinical trials using pharmaceutical nicotine products. | 2020-07-09 |
| 32637095 | The common symptoms reported in patients with COVID-19 are fever, dry cough, dyspnoea and gastrointestinal symptoms such as vomiting and diarrhoea. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637104 | Changes in the clinical research paradigm has been fueled by large-scale biological data harvesting (biobanks), which is developed, analyzed, and managed by cheaper computing technology (big data), supported by greater flexibility in study design (real-world data) and the relationships between industry, government regulators, and academics. […] The goal of this descriptive review is to create awareness of the ramifications for big data and to encourage readers that this trend is positive and will likely lead to better clinical solutions, but, caution must be exercised to reduce harm. | 2020-07-09 |
| 32637266 | Emerging evidence reports the impact of several co-morbidities on the clinical features and outcomes of COVID-19. […] Herein, we are presenting two patients with COVID-19 who initially presented with signs and symptoms of lithium toxicity. | 2020-07-09 |
| 32637278 | The clinical picture varies from asymptomatic or mild cases to critically ill patients. […] We present a case report of a 78-year-old male with multiple co-morbidities initially presenting with cardiac arrest and COVID-19 who showed drastic clinical improvement after he was administered a packed red blood cell transfusion. […] Poor clinical outcomes of critically ill patients are most likely due to the impaired gaseous exchange in the lungs in addition to the decreased oxygen-carrying capacity caused by the destruction of red blood cells. | 2020-07-09 |
| 32637289 | The questionnaire assessed the awareness of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) incubation period, the known symptoms of COVID-19, the mode of transmission of SARS-CoV-2, and infection control measures for prevention. | 2020-07-09 |
| 32637327 | We present the clinical course, pre- and post-partum management, and outcomes of two pregnant women critically ill with COVID-19. […] Both women had confirmed SARS-CoV-2 pneumonia with rapid clinical decompensation that required admission to the intensive care unit, intubation, and delivery by emergency cesarean section at 32 and 29 weeks. […] Both patients clinically improved in the first two postoperative days, but this was followed by clinical, laboratory and radiological deterioration on the third postoperative day; however, they both improved again after full anticoagulation. | 2020-07-09 |
| 32637423 | This enabled estimation of the serial interval for clinical cases, as well as reproduction numbers for small and large regions. | 2020-07-09 |
| 32637437 | Digestive symptoms and gastrointestinal (GI) manifestations are increasingly being reported in patients with the virus. […] We present a patient diagnosed with coronavirus who presented with several days of GI symptoms and discuss the relevance of GI disease and liver injury in these patients. | 2020-07-09 |
| 32637887 | It is known that infection is not severe and may even progress without symptoms in patients who have come into contact with COVID-19. | 2020-07-09 |
| 32637987 | Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological and neuropsychiatric illness. […] Detailed clinical and paraclinical data were collected from cases where the diagnosis of COVID-19 was confirmed through RNA PCR, or where the diagnosis was probable/possible according to World Health Organization criteria. […] Further clinical, neuroradiological, biomarker and neuropathological studies are essential to determine the underlying pathobiological mechanisms, which will guide treatment. | 2020-07-09 |
| 32638022 | Here, the clinical data were collected during hospitalization and follow-up of this patient. | 2020-07-09 |
| 32638053 | Special considerations include: a) cancellation or rescheduling of unnecessary imaging tests, b) a relevant questionnaire on the request form informing about patient and accompanying person’s symptoms and likely exposure in addition to general triage, c) appropriate patient and parent protective measures, d) recruitment and selection of US machines in different protected areas depending on the possibility or certainty for the infection, e) regular personnel protective measures and personal hand hygiene, f) routine disinfection of probes and adjacent surfaces and g) machine/room deep disinfection, if required. | 2020-07-09 |
| 32638151 | Symptoms of Kawasaki disease in general and incomplete Kawasaki disease have been seen in a subset of pediatric patients having a current or previous infection of SARS-CoV-2. […] A viral infection, such as a SARS-CoV-2 virus infection, could result in extensive antigen-antibody immune complexes that cannot be quickly cleared in a subset of patients and thus create a type III hypersensitivity immune reaction and cause Kawasaki disease or Kawasaki disease symptoms (also known as multisystem inflammatory syndrome) in a subset of patients. […] Extensive binding of antibodies to viral antigens can create antigen-antibody immune complexes, which, if not eliminated in certain individuals having dysfunctional complement systems, can start inflammatory type III hypersensitivity symptoms, including protease releases that can disrupt epithelium, mesothelium, and endothelium basement membranes, and induce pervasive inflammation throughout the body. | 2020-07-09 |
| 32638221 | Understanding these different routes is important as they pertain to clinical practice, especially in taking preventative measures to mitigate the spread of SARS-CoV-2. | 2020-07-09 |
| 32638333 | In order to face pandemic, in a period in which a large number of emergency room accesses with suspicious symptoms are expected, physicians need a standardized ultrasonographic approach, fast educational processes in order to be able to recognize both suggestive and not suggestive echographic signs and shared algorithms for LUS role in early management of patients. | 2020-07-09 |
| 32638344 | The potential differences between a clinical diagnosis of coronavirus disease 2019 (COVID-19) (i.e., symptoms without positive virus test) and a microbiological diagnosis (i.e., positive virus test results) of COVID-19 are not known. […] This study explored the differences between the two types of COVID-19 diagnosis among older patients in terms of clinical characteristics and outcomes. […] Clinical and laboratory data on hospital admission and outcomes (discharged or died in hospital) of all patients were retrieved from medical records retrospectively. […] Patients who met the criteria for clinical diagnosis with negative virus test results were assigned to the clinical diagnosis group, whereas those with positive virus test results were assigned to the microbiological diagnosis group. […] The clinical and microbiological diagnosis groups demonstrated significant differences in outcomes and in the majority of laboratory findings. […] Patients with similar signs, symptoms, and laboratory and imaging findings as confirmed COVID-19 cases may have a similar mortality risk, regardless of the virus test results, and require timely intervention to reduce their mortality. | 2020-07-09 |
| 32638347 | We note clinical and biological worsening during the second episode of COVID-19 for all three patients. […] It raises questions in clinical practice about the value of testing for SARS-CoV-2 infection again in the event of symptomatic reoccurrence. | 2020-07-09 |
| 32638507 | From 1584 COVID-19 patients, 364 severe/critical COVID-19 patients with clinical outcome were enrolled for the final analysis, and patients without preexisting T2DM but elevated glucose levels were excluded. […] Epidemiological data were obtained and clinical status evaluation carried out to assess the impact of T2DM and its management on clinical outcomes. […] T2DM status aggravated the clinical condition of COVID-19 patients and increased their critical illness risk. | 2020-07-09 |
| 32638559 | However, patients with severe asthma/allergic disease requiring systemic corticosteroids or immunosuppressive agents may be at higher risk of more severe clinical course of this infectious disease. […] We report this consensus to support allergists and clinical immunologists to make optimal decisions under the urgent situation in Asia. | 2020-07-09 |
| 32638613 | The diagnosis of novel coronavirus disease 2019 (COVID-19) has been a challenge in many countries due to nonspecific symptoms and variable incubation period. […] In this report, we will discuss the clinical relevance of each test and the current Centers for Disease Control and Prevention and American College of Radiology recommendations regarding the use of imaging in the diagnosis of COVID-19. | 2020-07-09 |
| 32638628 | At present, potential therapeutic targets and drugs for SARS-CoV-2 are continuously reported, and many repositioning drugs are undergoing extensive clinical research, including remdesivir and chloroquine. | 2020-07-09 |
| 32638647 | Safety and efficacy of the proposed treatment should be assessed by randomised controlled clinical trials. | 2020-07-09 |
| 32638712 | This study provides robust support for further evaluation and validation of this novel technology in a clinical setting and highlights challenges inherent in assessment of serological tests for an emerging disease such as COVID-19. | 2020-07-09 |
| 32638884 | Chloroquine (CQ) and its analog hydroxychloroquine (HCQ) were recently included in several clinical trials as potential prophylactic and therapeutic options for SARS-COV-2 infection/covid-19. […] Despite some initial promising in vitro results, rigorous pre-clinical animal studies and randomized clinical trials have not been performed yet. | 2020-07-09 |
| 32638888 | The average time between the onset of symptoms and death was 18 (1 - 56) days. | 2020-07-09 |
| 32638896 | Infection with the coronavirus known as COVID-19 has promoted growing interest on the part of cardiologists, emergency care specialists, intensive care specialists, and researchers, due to the study of myocardial involvement based on different clinical forms resulting from immunoinflammatory and neurohumoral demodulation.Myocardial involvement may be minimal and identifiable only by electrocardiographic changes, mainly increased cardiac troponins, or, on the other side of the spectrum, by forms of fulminant myocarditis and takotsubo syndrome.The description of probable acute myocarditis has been widely supported by the observation of increased troponin in association with dysfunction. […] Cardiac monitoring of these patients is, therefore, important in order to monitor the development of the phenotype of dilated myocardiopathy.This review presents the main etiological and physiopathological findings, a description of the taxonomy of these types of cardiac involvement, and their correlation with the main clinical forms of the myocardial component present in patients in the acute phase of COVID-19. | 2020-07-09 |
| 32638909 | Only if the results of these tests are positive or if fever or other symptoms suggestive of COVID-19 are present should the surgical procedure be postponed until the patient completely recovers. | 2020-07-09 |
| 32638911 | The disease has distinct clinical presentations, from asymptomatic to critical cases, with high lethality. | 2020-07-09 |
| 32638966 | Additionally, the cytokine storm present in severe cases leads to an increased inflammatory state, which may deteriorate the clinical prognosis in this population. | 2020-07-09 |
| 32639062 | These serious unpredictable reactions occurring in chronic real-world tocilizumab use may support patient care and monitoring of ongoing clinical trials. | 2020-07-09 |
| 32639084 | Recent retrospective studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) revealed that the patients with common comorbidities of cancers and chronic diseases face significantly poorer clinical outcomes than those without. | 2020-07-09 |
| 32639183 | In addition, the clinical uses of these molecules are explored, such as in the treatment of inflammatory conditions including sepsis and Kawasaki disease, which has recently been associated with severe acute respiratory syndrome coronavirus 2 infection in children. | 2020-07-09 |
| 32639216 | The visible presence of clinical leads well sighted on every aspect of the response guaranteed standardisation of procedures, while sustaining a vital feedback loop. | 2020-07-09 |
| 32639233 | In-vitro data suggest that high concentrations and thus high doses are needed for COVID-19 infections, but as yet there is no convincing evidence of clinical efficacy. | 2020-07-09 |
| 32639309 | Clinic schedules and patient charts were reviewed to determine clinical volumes and no-show proportions. | 2020-07-09 |
| 32639466 | Critical illness was associated with older age (p = 0.017), longer duration of symptoms (p = 0.036), and lower oxygen saturation on presentation (p = 0.016); with more thrombocytopenia (p = 0.015); higher C-reactive protein (p = 0.031); and lower WBC count (p = 0.039). | 2020-07-09 |
| 32639570 | Prevalence of clinical characteristics, symptoms, examination signs, and EMS impression and care. […] Based on EMS evaluation, 43 of 147 encounters (29.3%) had no symptoms of fever, cough, or shortness of breath. […] The findings of this cohort study suggest that screening based on conventional COVID-19 symptoms or corresponding examination findings of febrile respiratory illness may not possess the necessary sensitivity for early diagnostic suspicion, at least in the prehospital emergency setting. | 2020-07-09 |
| 32639578 | National needs assessment (online survey) of associated health trainees and medical fellows affiliated with Geriatric Research Education and Clinical Centers (GRECCs). | 2020-07-09 |
| 32639581 | Here, we describe two women infected with SARS-CoV-2 whose real-time reverse transcriptase-polymerase chain reaction (RT-PCR) test results and symptoms changed during the menstrual cycle. | 2020-07-09 |
| 32639711 | Targeting the treatment of brain infection, it has also been a challenge that the clinical drug should have good CNS penetration ability to cross the blood-brain barrier. | 2020-07-09 |
| 32639848 | In addition to the typical respiratory response, new coronavirus disease 2019 (COVID-19) is also associated with very common gastrointestinal symptoms. […] Cases with gastrointestinal symptoms are more likely to be complicated by liver injury and acute respiratory distress syndrome (ARDS). […] As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects the human body through the combination of angiotensin-converting enzyme 2 (ACE2) in the gastrointestinal tract, the mechanism underlying the gastrointestinal symptoms may involve damage to the intestinal mucosal barrier and promotion of the production of inflammatory factors. […] Thus, treatment options for COVID-19 patients should be promptly adjusted when they have gastrointestinal symptoms. | 2020-07-09 |
| 32639849 | Methods: We describe the technological, administrative, training, and clinical implementation components involved in transitioning a comprehensive outpatient child and adolescent psychiatry program to a HB-TMH virtual clinic. | 2020-07-09 |
| 32639862 | Triage urgency was determined based on clinical assessment of urgency with which a patient would require medical treatment or surgical intervention. […] Clinical conditions were classified into six categories of: (1) venous thromboembolism (VTE), (2) chronic venous disease, (3) vascular anomalies, (4) venous trauma, (5) venous compression and (6) lymphatic disease. […] Venous and Lymphatic Triage and Acuity Scale aims to standardise the triage of patients with venous and lymphatic disease or vascular anomalies by providing an international consensus-based classification of clinical categories and triage urgency. | 2020-07-09 |
| 32639866 | The evidence of RAS arm disequilibrium in COVID-19 and the hypothesis of a beneficial role of RAS modulation supported by preclinical and clinical studies are the focus of the present review. […] Preclinical and clinical studies on drugs balancing RAS arms might be the right way to counter COVID-19. | 2020-07-09 |
| 32640019 | Recently, results from at least three major randomized clinical trials studying management of COVID-19 have been announced via press release without accompanying information. […] Herein, we propose a minimum set of trial characteristics and results to be released simultaneously with clinical trial announcements. | 2020-07-09 |
| 32640030 | The secondary outcomes included patient age, sex, and race if stated; dates the specimen was obtained and the test result; clinical practice site sources; geo-location of patient residence; and hospitalization. | 2020-07-09 |
| 32640169 | Understanding the pathogenesis of certain viral agents is essential for developing new treatments and obtaining a clinical cure. | 2020-07-09 |
| 32640172 | The current article provides an overview of the cellular mechanisms involved in the pathogenetic roles of PARP1 in ALI, and overviews the preclinical data supporting the efficacy of PARP inhibitors. […] In recent years, several ultrapotent PARP inhibitors have been approved for clinical use (for the therapy of various oncological diseases): these newly-approved PARP inhibitors were recently reported to show efficacy in animal models of ALI. | 2020-07-09 |
| 32640179 | In response to the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), researchers are expeditiously searching for antiviral treatments able to alleviate the symptoms of infection, which can be life-threatening. | 2020-07-09 |
| 32640331 | In the present manuscript we have reviewed scientific data from recent publications regarding the beneficial cellular and molecular effects induced by dietary plant products, mainly polyphenolic compounds and PUFAs, and summarize the clinical outcomes expected from these types of interventions, in a search for effective long-term approaches to improve the immune system response. | 2020-07-09 |
| 32640416 | We suggest ‘personalization’ of chronic disease management, which can be used with other interventions, in order to tackle this. | 2020-07-09 |
| 32640417 | The characteristic clinical symptoms for Coronavirus (COVID-19) affected patients are high fever, dry-cough, dyspnoea, lethal pneumonia whereas some patients also show additional neurological signs such as headache, nausea, vomiting etc. […] We discuss the need for modulations in clinical approach from a neurological point of view, as a measure towards reducing disease transmission, morbidity and mortality in SARS-CoV2 positive patients. | 2020-07-09 |
| 32640418 | While the disease primarily presents as a respiratory illness, gastrointestinal symptoms such as diarrhea have been reported in up to one-third of confirmed cases, and patients may have mild symptoms that do not prompt them to seek medical attention. […] Internet-based infodemiology offers an approach to studying symptoms at a population level, even in individuals who do not seek medical care. […] This study aimed to determine if a correlation exists between internet searches for gastrointestinal symptoms and the confirmed case count of COVID-19 in the United States. […] The search terms chosen for analysis in this study included common gastrointestinal symptoms such as diarrhea, nausea, vomiting, and abdominal pain. […] Daily query shares for the selected symptoms were obtained from Google Trends between October 1, 2019 and June 15, 2020 for all US states. […] The relative search query shares of many symptoms, including nausea, vomiting, abdominal pain, and constipation, remained near or below baseline throughout the time period studied; however, there were notable increases in searches for the positive control symptoms of fever and cough as well as for diarrhea. […] Google searches for symptoms may precede the actual rises in cases and hospitalizations during pandemics. | 2020-07-09 |
| 32640419 | The results showed that the nursing staff provided the fewest correct answers to questions about continuous viral nucleic acid testing specifications (379/979 correct answers, 38.7%), isolation/discharge criteria (539/979 correct answers, 55.1%), and management measures for patients with suspected symptoms (713/979 correct answers, 72.8%). | 2020-07-09 |
| 32640463 | We have quantified a range of clinical factors associated with COVID-19-related death in one of the largest cohort studies on this topic so far. | 2020-07-09 |
| 32640479 | We found 11 studies (1 clinical trial, 7 retrospective cohorts and 3 prospective cohorts), which included a range of 16 to 388 in patients with COVID-19 (total of 1369 inpatients). […] The majority suggested universal pharmacological thromboprophylaxis in all COVID-19 inpatients, but there was heterogeneity in the suggested intensity of thromboprophylaxis: seven advised considering intensified doses of heparin according to the clinical or biological severity of the disease, especially in the ICU setting. […] Venous thromboembolism very commonly complicates the clinical course of inpatients with COVID-19, despite thromboprophylaxis. […] This situation calls for fast randomised clinical trials, comparing different schemes of thromboprophylaxis in COVID-19 inpatients. | 2020-07-09 |
| 32640487 | Clinical trials with BTK inhibitors in COVID-19 treatment have been proposed, and previous studies have attempted to investigate the therapeutic effects of ibrutinib and underlying mechanisms in treating viral pneumonia. | 2020-07-09 |
| 32640684 | In summary, age and type of sport, which are important factors for the COVID-19 infection and symptoms, were found to affect the sport activity patterns. | 2020-07-10 |
| 32640752 | The idea is to avoid a surge of patients with severe symptoms beyond the capacity of the hospitals’ medical resources, which would lead to more mortality and morbidity. | 2020-07-10 |
| 32640852 | The coronavirus disease 2019 (COVID-19) pandemic is a global health emergency requiring clinicians to be prepared to cope with the increase in the future incidence of trauma and stress-related psychopathological symptoms. […] Clinicians should also consider integrating new technologies such as virtual reality (VR) in the treatment of these trauma and stress-related psychopathological symptoms. | 2020-07-10 |
| 32640936 | The coronavirus disease 2019 (COVID-19) pandemic has created new challenges that necessitate prompt responses in unexpected clinical situations. […] The current case report provides clinical data of relevance to the largely unexplored question of the immunologic complications of COVID-19 in patients with a pre-existing inflammatory state. | 2020-07-10 |
| 32640950 | In total 527 people were identified as close contacts over the same period; 493 were successfully contacted; 445 were located in the NT and were subsequently quarantined and monitored for disease symptoms daily for 14 days after contact with a confirmed COVID-19 case. […] Of these 445 close contacts, 4 tested positive for COVID-19 after developing symptoms; 2/46 contacts who were cruise ship passengers (4.3%, 95% CI 0.5-14.8%) and 2/51 household contacts (3.9%, 95% CI 0.5-13.5%). | 2020-07-10 |
| 32641013 | By sharing the clinical characteristics, treatments and outcomes of 18 patients with COVID-19 during late pregnancy, we hope to provide some references for obstetric treatment and management. […] The epidemiological characteristics, clinical manifestations, laboratory tests, chest CT and pregnancy outcomes were performed for analysis. […] According to the clinical classification of COVID-19, 1 case was mild type, 16 cases were ordinary type, and 1 case was severe type. | 2020-07-10 |
| 32641059 | The most common symptoms of COVID-19 are fever, cough, and dyspnea. […] This work aimed to provide insight on the newly emerged COVID-19, in the hope to gain a better understanding on the general overview, epidemiology, transmission, clinical features, diagnosis, treatment, and clinical outcomes as well as the prevention and control of COVID-19. | 2020-07-10 |
| 32641091 | This is a prospective, open-label, randomized controlled, multicenter clinical study. […] The primary outcome is the clinical recovery time at no more than 28 days after the completion of therapy and follow-up. […] Chinese Clinical Trial Registry, ID: ChiCTR2000029741 . | 2020-07-10 |
| 32641121 | The clinical spectrum of COVID-19 is extensive, of which critical cases are with rapid disease progression and high mortality. […] According to the definition of clinical classification, we divided confirmed cases into four types, and summarize epidemiological and clinical characteristics, laboratory and radiograph findings, treatments, and outcomes, respectively. […] Multivariate ordinal logistic regression demonstrated increasing odds of the severity of illness in patients with COVID-19 associated with male (odds ratio [OR] = 1.7, 95% confidence interval [CI]: 1.2-2.6 P = 0.008), fever (OR = 3.6, 95% CI: 2.1-6.3, P < 0.001), cough (OR = 1.7, 95% CI: 1.0-2.9, P = 0.041), hemoptysis (OR = 3.4, 95% CI: 1.1-10.3, P = 0.032), gastrointestinal symptoms (OR = 1.9, 95% CI: 1.0-3.5, P = 0.047), hypertension (OR = 2.6, 95% CI: 1.2-5.6, P = 0.013). […] Clinicians should pay close attention to these features in patients with COVID-19 including older age, male, fever, cough, hemoptysis, gastrointestinal symptoms and hypertension to identify the severity of illness as early as possible. | 2020-07-10 |
| 32641154 | Randomised, parallel 3-arm (1:1:1 ratio), open-label, Phase IV platform trial of immunomodulatory therapies in patients with late stage 1 or stage 2 COVID-19-related disease, with a diagnosis based either on a positive assay or high suspicion of COVID-19 infection by clinical and/or radiological assessment. […] Patients aged 18 and over, with a clinical picture strongly suggestive of COVID-19-related disease (with/without a positive COVID-19 test) AND a Risk count (as defined below) >3 OR ≥3 if risk count includes “Radiographic severity score >3”. […] Registered on EU Clinical Trials Register EudraCT Number: 2020-001354-22 Registered: 6 May 2020 It was registered on ClinicalTrials.gov (NCT04390464) and on ISRCTN (ISRCTN11188345) FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). | 2020-07-10 |
| 32641163 | Exclusion criteria include duration symptoms of febrile disease for ≥ 1 week, treatment limitations in place or moribund patients, allergy or intolerance of any study treatment, and pregnancy. […] This trial is designed and powered to investigate whether the treatment in this cohort of patients leads to improved clinical patient-centred outcomes, such as mechanical ventilation-free survival. […] Clinical trials.gov: NCT04339816 (Registered on 9 April 2020, amended on 22 June 2020); Eudra CT number: 2020-001456-18 (Registered on 29 March 2020). | 2020-07-10 |
| 32641169 | Since the outbreak of Coronavirus Disease 2019 (COVID-19) in December 2019, many studies have reported the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the conjunctival sac of patients infected with this virus, with several patients displaying symptoms of viral conjunctivitis. […] A 53-year-old man confirmed with COVID-19 developed symptoms of viral conjunctivitis in the left eye approximately 10 days after the onset of COVID-19. […] The symptoms were relieved 6 days after treatment. […] However, the patient was subsequently diagnosed with viral keratoconjunctivitis in both eyes 5 days after the symptoms in the left eye were satisfactorily relieved. […] Both eyes were treated with glucocorticoids, and symptoms were controlled within 5 days. […] In this case report, the pathogenesis, clinical manifestations, treatment, and outcome of a case with COVID-19 complicated by relapsing viral keratoconjunctivitis is described, and the involvement of topical cytokine surge in the pathogenesis of COVID-19 as it relates to viral keratoconjunctivitis is reported. | 2020-07-10 |
| 32641226 | However, fewer than 1% of patients in the PARADIGM-HF study had New York Heart Association (NYHA) functional class IV symptoms. […] The trial planned to randomize 400 patients ≥18 years of age with advanced HF, defined as an EF ≤35%, New York Heart Association functional class IV symptoms, elevated natriuretic peptide concentration (B-type natriuretic peptide [BNP] ≥250 pg/ml or N-terminal pro-B-type natriuretic peptide [NT-proBNP] ≥800 pg/ml), and ≥1 objective finding of advanced HF. […] Secondary and tertiary endpoints included clinical outcomes and safety and tolerability. […] The primary analysis consists of the first 335 randomized patients whose clinical follow-up examination results were not severely impacted by COVID-19. | 2020-07-10 |
| 32641343 | A high dose of intravenous VC (HIVC) was proven to block several key components of cytokine storms, and HIVC showed safety and varying degrees of efficacy in clinical trials conducted on patients with bacterial-induced sepsis and acute respiratory distress syndrome (ARDS). […] This is one of the first clinical trials applying HIVC to treat COVID-19, and it will provide credible efficacy and safety data. […] The study protocol was approved by the Ethics Committee of Zhongnan Hospital of Wuhan University (identifiers: Clinical Ethical Approval No. | 2020-07-10 |
| 32641351 | Data related to the applicability of the Clinical Frailty Scale (CFS) for risk stratification in patients with COVID-19 are currently lacking. | 2020-07-10 |
| 32641443 | This is a case of a patient who presented with an urticarial rash 48 hours before developing symptoms of fever and a continuous cough. […] Urticarial rashes occurring 48 hours before other symptoms of COVID-19 infection have been documented. | 2020-07-10 |
| 32641456 | We start by relating two very personal experiences that shaped not only life following loss, but also career choices, clinical practices, and scholarship. | 2020-07-10 |
| 32641471 | The impact of liver injury on adverse clinical outcomes in coronavirus disease 2019 (COVID-19) patients remains unclear. […] ALT/AST elevation was common and independently associated with adverse clinical outcomes in COVID-19 patients. | 2020-07-10 |
| 32641525 | Patient data were obtained from medical records from the Hospital Universitario 12 de Octubre in Madrid, Spain. […] Significant improvement in the parkinsonian symptoms was observed without any specific treatment. […] This case study provides clinical and functional neuroimaging evidence to support that SARS-CoV-2 can gain access to the CNS, affecting midbrain structures and leading to neurologic signs and symptoms. | 2020-07-10 |
| 32641644 | Millions around the world are wondering, if there is anything that could be done, other than maintaining high personal hygiene, and be vigilant of the symptoms, to reduce the spread of the disease and chances of getting infected, or at least to lessen the burden of the disease, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). | 2020-07-10 |
| 32641700 | Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19. | 2020-07-10 |
| 32641873 | The patients of COVID-19 present with a clinical feature resembling mild form of viral pneumonia which in certain cases progress to a severe form characterised by adult respiratory distress syndrome (ARDS) and/or multiorgan failure leading to death. | 2020-07-10 |
| 32641874 | In this review, we will study the cellular and molecular aspects of hydroxychloroquine, which had driven its use in Covid-19 patients, as well as its chemistry and pharmacokinetics along with clinical trials going on worldwide using hydroxychloroquine against Covid-19. | 2020-07-10 |
| 32641901 | Recently a novel coronavirus (nCOVID-19) has first emerged in China, causing multiple symptoms in humans and closely related to those caused by SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome). | 2020-07-10 |
| 32641924 | We provide an overview of the available literature regarding the association between smoking, risk of SARS-CoV-2 infection, and risk of severe COVID-19 and poor clinical outcomes, with the aim of informing public health policy and practice, particularly in England. | 2020-07-10 |
| 32641974 | Data on demographic, clinical and outcome (in-hospital mortality) data were obtained from electronic medical records. | 2020-07-10 |
| 32641977 | To make it easier for scientists working on SARS-CoV-2 to identify and apply specific tools, we discuss how they could accelerate the discovery and preclinical development of antiviral drugs and vaccines, compared to conventional models. | 2020-07-10 |
| 32641984 | Quantitative nucleic acid testing has become the gold standard for diagnosis and guiding clinical decisions regarding the use of antiviral therapy. | 2020-07-10 |
| 32641989 | Afterward, we conducted a Fine-Gray competing risk regression to build the clinical model and the clinic-radiomics signature (CrrScore). […] Finally, performances of the three prognostic signatures (clinical model, RadScore, and CrrScore) were estimated from the two aspects: 1) cumulative poor outcome probability prediction; 2) 28-day poor outcome prediction. […] For the early-phase patients, integrating radiomics signature with clinical risk factors can achieve a more accurate prediction of individual poor prognostic outcome, which enables appropriate management and surveillance of COVID-19. | 2020-07-10 |
| 32642005 | Here, we will discuss the following subtopics: 1) ACE2 as a receptor of SARS-CoV-2; 2) clinical and pathological features of COVID-19; 3) role of ACE2 in the infection and pathogenesis of SARS; 4) potential pathogenic role of ACE2 in COVID-19; 5) animal models for pathological studies and therapeutics; and 6) therapeutics development for COVID-19. | 2020-07-10 |
| 32642164 | Patients with epidemiologic history, respiratory symptoms or fever were required to go to the fever clinic for screening. […] Epidemiologic features, clinical presentation, laboratory findings and image features were collected and analyzed. […] The most common symptoms of the patients were fever (87.50%) and cough (n=8, 50.00%). | 2020-07-10 |
| 32642354 | Nevertheless, the symptoms reflected after infection from the coronaviruses take some time before being identified. | 2020-07-10 |
| 32642757 | At the moment, Nanopore pathogen sequencing and antibody detection have been found effective in clinical diagnosis. | 2020-07-10 |
| 32642929 | This study evaluates the impact of an adapted telemedicine Objective Structured Clinical Examination (OSCE) on telemedicine-specific training competencies of residents. | 2020-07-10 |
| 32643004 | COVID-19 infection has tremendously impacted our daily clinical practice as well as our social living organization. | 2020-07-10 |
| 32643133 | Clinicians should closely monitor and manage the symptoms of COVID-19 patients who are over the age of 70 years or have chronic lung disease or AD. | 2020-07-10 |
| 32643136 | Respiratory and gastrointestinal manifestations of SARS-CoV-2 are well described, less defined is the clinical neurological spectrum of COVID-19. […] A 68 years-old man presented to the emergency department with symptoms of acute progressive symmetric ascending flaccid tetraparesis. […] COVID-19 associated neurological clinic should probably be seen not as a corollary of classic respiratory and gastrointestinal symptoms, but as SARS-CoV-2-related standalone clinical entities. | 2020-07-10 |
| 32643200 | It could also be used for prophylactic purposes but the safety and effectiveness of this approach should be tested in randomized prospective clinical trials. | 2020-07-10 |
| 32643218 | We describe the current clinical diagnostics and technology, including molecular and serological testing approaches, for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) testing as well as address their advantages and limitations. […] Antibody response against SARS-CoV-2 remains poorly understood and proper validation of serology tests is necessary to demonstrate their accuracy and clinical utility. […] In order to bring the pandemic under control, we must speed up the development of rapid and widespread testing through improvements in clinical diagnostics and testing technology as well as access to these tools. | 2020-07-10 |
| 32643436 | Several vaccine projects have seen successes in preclinical, phase I, and phase II clinical trials using recombinant DNA, mRNA, live attenuated virus, S-protein subunits, virus like particles, and viral vectors. […] Immunomodulatory molecules such as sarilumab, tocilizumab, janus kinase inhibitors, and hyperimmune convalescent plasma have mixed outcomes from initial clinical findings; however, pending randomised controlled trials will assist national health institutions to make treatment recommendations for COVID-19. | 2020-07-10 |
| 32643467 | Radical changes to clinical and endoscopy practice have been rapidly introduced following the spread of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). | 2020-07-10 |
| 32643489 | Although involvement of the lower respiratory track accounts for most of the morbidity and mortality seen, the virus involves several organ systems and the syndrome exhibits clinical diversity with a wide range of symptoms and manifestations. | 2020-07-10 |
| 32643510 | From 16 to 21 February 2020, an online survey was conducted, which collected the information on demographic data, anxiety, social support and risk perception to COVID-19 of women with established medical records in the ambulatory of the Department of Obstetrics at the Affiliated Hospital of Qingdao University. | 2020-07-10 |
| 32643552 | Many synthetic compounds and antimalarial drugs are undergoing clinical trials. | 2020-07-10 |
| 32643663 | Neurological manifestations are also being observed in clinical presentations. | 2020-07-10 |
| 32643708 | The presence of IgA antibodies against SARS-CoV-2 has been confirmed in the milk of infected women, so BF could reduce the clinical impact of the disease in the infant, if it becomes infected. | 2020-07-10 |
| 32643783 | During this period, the activities of the public Homeopathy Outpatient Clinic of Lucca aimed at guaranteeing therapeutic continuity to patients by means of telephone or video consultations, and searching for homeopathic medicines that best responded to early COVID-19 symptoms. […] The medical staff of the Lucca Clinic also cooperated in telephone health surveillance of infected patients at home, seroprevalence investigations using the capillary blood rapid test, and the implementation of the CLIFICOL (Clinical Files Collection) project. | 2020-07-10 |
| 32643844 | Patients experienced: 1. reduced access to eating disorder (ED) services; 2. disruption to routine and activities in the community; 3. heightened psychological distress and ED symptoms; 4. increased attempts at self-management in recovery. […] Reduced access to ED services, loss of routine and heightened anxieties and ED symptoms resulting from COVID-19 and lockdown measures presented challenges for patients and carers. | 2020-07-10 |
| 32644140 | Patients were divided into 5 groups based on the date of their clinical presentation in relation to the COVID-19 pandemic. | 2020-07-10 |
| 32644215 | In this study, we aimed to highlight the common early-stage clinical and laboratory variables independently related to the acute phase duration in patients with uncomplicated coronavirus disease (COVID-19) pneumonia. […] Noninvasive ventilation was administered based on clinical judgment. […] For parameters to be measured at the hospital entrance, age, clinical history, National Early Warning Score2 (NEWS2, a multiparametric score system), partial pressure of oxygen in arterial blood/fraction of inspired oxygen (P/F ratio), C-reactive protein, and blood cell count were selected. | 2020-07-10 |
| 32644263 | We used a combination of assessment technologies in a high-fidelity simulation model (fresh porcine cadaver) as well as during clinical surgery to examine gas flow through the Airseal 12mm valve-less trocar with the Airseal IFS carbon dioxide (CO2) insufflator in Airseal mode. | 2020-07-10 |
| 32644266 | Why COVID-19 patients with the same clinical condition have different outcomes remains unclear. | 2020-07-10 |
| 32644275 | To date, data is limited for medications that facilitate clinical improvement of COVID-19 infections. | 2020-07-10 |
| 32644876 | The coronavirus disease 2019 (COVID-19) is a pandemic caused by coronavirus with mild to severe respiratory symptoms. […] However, further clinical trials are needed to confirm these findings and presenting the strong recommendations against this pandemic. | 2020-07-10 |
| 32644981 | This report describes the characteristics and clinical outcomes of adult patients with laboratory-confirmed COVID-19 treated at BMC during March 1-May 18, 2020. […] During this time, 2,729 patients with SARS-CoV-2 infection were treated at BMC and categorized into one of the following mutually exclusive clinical severity designations: exclusive outpatient management (1,543; 56.5%), non-intensive care unit (ICU) hospitalization (900; 33.0%), ICU hospitalization without invasive mechanical ventilation (69; 2.5%), ICU hospitalization with mechanical ventilation (119; 4.4%), and death (98; 3.6%). […] Clinical severity differed by age, race/ethnicity, underlying medical conditions, and homelessness. […] Patient characteristics associated with illness and clinical severity, such as age, race/ethnicity, homelessness, and underlying medical conditions can inform tailored strategies that might improve outcomes and mitigate strain on the health care system from COVID-19. | 2020-07-10 |
| 32644985 | Repeated point prevalence surveys (serial testing of all residents and health care personnel at a health care facility irrespective of symptoms) have been used to identify asymptomatic infections and have reduced SARS-CoV-2 transmission during SNF outbreaks (1,3). | 2020-07-10 |
| 32645044 | We report the clinical characteristics of 82 cases of death from COVID-19 in a single center. […] Clinical data on 82 death cases laboratory-confirmed as SARS-CoV-2 infection were obtained from a Wuhan local hospital’s electronic medical records according to previously designed standardized data collection forms. […] The median time from initial symptoms to death was 15 days (IQR 11-20), and a significant association between aspartate aminotransferase (p = 0.002), alanine aminotransferase (p = 0.037) and time from initial symptoms to death was remarkably observed. | 2020-07-10 |
| 32645053 | One of nine patients with a non-suspicious CT and a positive PCR had developed symptoms within 48 hours before scanning. | 2020-07-10 |
| 32645151 | Although the main clinical manifestations are respiratory, an increase in neurological conditions, specifically acute cerebrovascular disease, has been detected. […] Available data on comorbidity, laboratory parameters, treatment administered, neuroimaging, neuropathological studies and clinical evolution during hospitalization, measured by the modified Rankin scale, were analysed. | 2020-07-10 |
| 32645174 | There is growing appreciation of the wide range of clinical presentations seen in pediatric patients with coronavirus disease 2019 (COVID-19). | 2020-07-10 |
| 32645207 | Antimalarials, anti-IL6-Anti-IL6 receptor, anti-IL1, anti-GM-CSF receptor and JAK1/2/3 inhibitors, are under investigation in COVID-dedicated clinical trials to control the inflammation raised by SARS-CoV-2 infection. | 2020-07-10 |
| 32645219 | The primary aim of this issue of the Journal of Clinical Psychology: In Session is to demonstrate the myriad ways in which movies, their viewing and discussion, can be used to serve therapeutic and educational purposes. | 2020-07-10 |
| 32645327 | RBD-sc-dimers in pilot scale production yielded high yields, supporting their scalability for further clinical development. | 2020-07-10 |
| 32645347 | From April 27 to May 11, 2020, 61 075 participants (75·1% of all contacted individuals within selected households) answered a questionnaire on history of symptoms compatible with COVID-19 and risk factors, received a point-of-care antibody test, and, if agreed, donated a blood sample for additional testing with a chemiluminescent microparticle immunoassay. […] In 7273 individuals with anosmia or at least three symptoms, seroprevalence ranged from 15·3% (13·8-16·8) to 19·3% (17·7-21·0). […] Most PCR-confirmed cases have detectable antibodies, but a substantial proportion of people with symptoms compatible with COVID-19 did not have a PCR test and at least a third of infections determined by serology were asymptomatic. | 2020-07-10 |
| 32645391 | Thus, new ideas for an appropriated assessment of patients’ condition and clinical treatment are of utmost importance. | 2020-07-10 |
| 32645392 | However, the dynamic changes in the clinical symptoms and prognosis of COVID-19 patients remain unknown. […] According to the onset time of initial clinical symptoms, 843 COVID-19 patients admitted between Jan 22 and Feb 14, 2020 were divided into three groups: group A (Jan 21 to Jan 25, n = 324), group B (Jan 26 to Jan 31, n = 358) and group C (Feb 1 to Feb 10, n = 161). […] Data on the demographics, symptoms, first laboratory results, treatments and outcomes (within 12 days of hospitalization) were collected. […] Fewer patients had fever symptoms and bilateral pneumonia in group C than in the group A and B. […] The clinical characteristics and prognosis of COVID-19 patients changed over time. | 2020-07-10 |
| 32645475 | The screening of infected people in the population still mainly depends on clinical symptoms. […] However, there is limited research on the characteristics of clinical symptoms in different populations, especially in imported cases. […] To retrospectively analyze the clinical data of 494 confirmed COVID-19 patients admitted to a designated hospital in Shanghai from January 20, 2020, to March 31, 2020, we compared the clinical manifestations in different populations and their influencing factors in COVID-19 patients. […] (1) Of the 494 patients, 453 (91.7%) had different symptoms at admission, and 39 (7.89%) patients were asymptomatic. […] (2) We compared the symptoms of patients according to different stratifications and found the following results: (a) The proportion of dyspnea was significantly higher in male patients than in female patients (P < .05). (b) The proportions of a stuffy nose, sore throat, and olfactory and gustatory dysfunction were significantly higher in children than in adult patients (P < .05). (c) The proportions of fever, chest tightness, shortness of breath, and fatigue were significantly higher in local cases than in imported cases. […] In comparison, the proportions of nasal congestion, stuffy nose, sore throat, headache, and olfactory and gustatory dysfunction were significantly lower in imported cases than in imported cases (P < .05). (d) The proportions of chest tightness, shortness of breath, and dyspnea were significantly higher in severely ill patients than in those with mild symptoms (P < .05). […] (4) The number of days since the onset of the disease needed for the symptoms to disappear was associated with the epidemiological history (imported cases), the number of days until the pharyngeal swab nucleic acid test turned negative, the days of hospitalization, the days of onset, and the white blood cell and lymphocyte count levels (P < .05). […] The majority of COVID-19 patients (91.7%) had early symptoms, whereas 7.89% of COVID-19 patients were asymptomatic. […] Younger patients had fewer symptoms, mainly the upper respiratory symptoms, and the illness condition was milder, which was more common in imported cases. […] Elderly male patients had severe symptoms when admitted. […] The number of days needed for the patient’s symptoms to disappear was closely related to the number of days necessary for the pharyngeal swab nucleic acid test to turn negative. | 2020-07-10 |
| 32645614 | The clinical significance of HNC-LL in accurately predicting the risk of future development of severe COVID-19 was confirmed. | 2020-07-10 |
| 32645620 | Telehealth services and virtual clinics offer accessible disease management pathways for patients living in health resource limited areas or, as in the case of the COVID-19 pandemic, where there may be potential barriers to existing healthcare resources. | 2020-07-10 |
| 32645630 | The use of type I interferons for coronavirus is still under great debate in clinical practice. | 2020-07-10 |
| 32645632 | Many studies have reported the clinical characteristics of COVID-19: sudden deterioration of disease around 1-2 weeks after onset; much lower level of lymphocytes, especially natural killer (NK) cells in peripheral blood; extremely high pro-inflammatory cytokines and C reactive protein (CRP). […] It has been demonstrated clinical benefits for the patients with rheumatoid arthritis (RA), active systemic lupus erythematosus and atopic dermatitis with good efficacy and safety records. […] Several clinical trials are currently investigating the drug, and one of which has been completed with encouraging results. […] In this paper, we will elaborate the role of cytokine storm mediated by JAK-STAT pathway in severe COVID-19, the possible mechanisms of baricitinib on reducing the viral entry into the target cells and cytokine storm, the key points of pharmaceutical care based on the latest research reports, clinical trials progress and drug instruction from the US FDA, so as to provide reference for the treatment of severe COVID-19. | 2020-07-10 |
| 32645636 | Although none of the participants were diagnosed with COVID-19, our results show that 2 participants with NMOSD experienced new onset of neurological symptoms and 2 experienced worsening of previous neurological symptoms - suggesting a possible effect of pandemic-related stress on this CNS autoimmune disorder. | 2020-07-10 |
| 32645974 | In vitro analyses of hydroxychloroquine (HCQ)’s anecdotal benefits prompted its widespread clinical repurposing globally. […] Reports of emerging cardiovascular complications due to its clinical prescription are revealing the crucial role of angiotensin-converting enzyme 2 (ACE2), which serves as a target receptor for SARS-CoV-2. […] While starting with the crucial role of ACE2, we here discuss the impact of HCQ on systemic cardiovascular function, its associated risks, and the scope of HCQ-based regimes in current clinical settings. […] Taken together, this review provides crucial insights into the role of ACE2 in SARS-CoV-2-led cardiovascular activity, and concurrently assesses the efficacy of HCQ in contemporary clinical settings. | 2020-07-11 |
| 32645994 | Even if marine organisms produce a wide variety of different compounds, there is only one compound available on the market, Ara-A, and only another one is in phase I clinical trials, named Griffithsin. | 2020-07-11 |
| 32646015 | Standard precautions to minimize the risk of SARS-CoV-2 transmission implies that infected cell cultures and clinical specimens may undergo some sort of inactivation to reduce or abolish infectivity. | 2020-07-11 |
| 32646234 | In order to accurately admit children with COVID-19 to an isolation ward, our study retrospectively analyzed the clinical characteristics of children in isolation wards during the COVID-19 epidemic. […] Therefore, for some suspected children with COVID-19, we can make a comprehensive judgment through clinical symptoms, epidemiological history, LYM number, myocardial enzyme spectrum, chest CT, and electrocardiogram; put these children in an isolation ward for treatment; and then transfer them to a general ward for treatment after excluding COVID-19. | 2020-07-11 |
| 32646309 | In addition, implications for future research and clinical practice are also discussed. | 2020-07-11 |
| 32646502 | Randomized clinical trial, controlled, open, parallel group, to evaluate the effectiveness of steroids in adult patients with confirmed COVID-19, with incipient pulmonary involvement, without hospital admission criteria. […] Patients will be followed-up by specialist physicians and Primary Health Care professionals. - Men and women. - Age between 18 and 75 years old. - Diagnosed SARS-CoV-2 infection, by PCR and/or IgM+ antibody test and/or antigen test. - Clinical diagnosis of lung involvement: (respiratory symptoms +/- pathological auscultation +/- O2 desaturation) - Chest X-ray with mild-moderate alterations or normal. - Patients who give their verbal informed consent in front of witnesses, which will be reflected in the patients’ medical records. - Oxygen desaturation below 93% or P02 < 62. - Moderate-severe dyspnea or significant respiratory or general deterioration that makes admission advisable. - Chest X-ray with multifocal infiltrates. - Insulin-dependent diabetes with poor control or glycaemia in the emergency room test greater than 300 mg/ml (fasting or not). - Other significant comorbidities: Severe renal failure (creatinine clearance < 30 mL/min); cirrhosis or chronic liver disease, poorly controlled hypertension. - Heart rhythm disturbances (including prolonged QT). - Severe immunosuppression (HIV infection, long-term use of immunosuppressive agents); cancer. - Pregnant or breast-feeding women. - Patients under use of glucocorticoids for other diseases. - History of allergy or intolerance to any of the drugs in the study (prednisone, azithromycin or hydroxychloroquine). - Patients who took one or more of the study drugs in the 7 days prior to study inclusion. - Patients taking non-suppressible drugs with risk of QT prolongation or significant interactions. - Patients unwilling or unable to participate until study completion. - Participation in another study. […] The safety variable will be the occurrence of clinical symptoms or delirium related to the steroids. | 2020-07-11 |
| 32646505 | Clinical follow up was mainly done by telephone and all patients had to complete a questionnaire regarding symptoms and contacts with COVID-19 patients before entering our department. […] Educational documents were created for patients to raise awareness of symptoms and avoidance strategies for interactions with other people. | 2020-07-11 |
| 32646729 | The more frequent symptoms in the pregnant women were fever, cough and dyspnoea. | 2020-07-11 |
| 32646770 | The purpose of the present study is to determine clinical characteristics associated with 28 day in-hospital survival in patients with coronavirus disease 2019 (COVID-19) that received tocilizumab. […] Clinical response was collected and defined as a decline of two levels on a six-point ordinal scale of clinical status or discharged alive from the hospital. […] On study day 0 no differences were noted in demographics, clinical characteristics, severity of illness scores, or treatments received between survivors and non-survivors. […] Clinical response occurred more commonly in survivors than non-survivors (80.4% vs. | 2020-07-11 |
| 32646885 | The most common COVID-19 symptoms were fever and cough, but 21.1% of patients had neurologic symptom recrudescence preceding or coinciding with the infection. | 2020-07-11 |
| 32646930 | Results from large, randomized clinical trials are pending. | 2020-07-11 |
| 32647045 | In the case of COVID-19, the disease’s public profile is based on clinical and non-clinical factors that include contagiousness, clinical presentation and media coverage. | 2020-07-11 |
| 32647056 | BCG vaccination clinical trials are required to corroborate the patterns detected here, and to establish causality between BCG vaccination and protection from severe COVID-19. | 2020-07-11 |
| 32647307 | Understanding this CT feature could help the clinical physician to predict the prognosis of the patients. | 2020-07-11 |
| 32647526 | To further characterize cerebrovascular disease (CVD) in COVID-19, we review the current literature of published cases and additionally report the clinical presentation, laboratory and diagnostic testing results of 12 cases with COVID-19 infection and concurrent CVD from two academic medical centers in Houston, TX, USA, between March 1 and May 10, 2020. […] However, only 4 small case series have described the clinical and laboratory findings in patients with COVID-19 and concurrent stroke. | 2020-07-11 |
| 32647672 | The diagnosis and evaluation of familial outbreaks requires a collective consideration of epidemiological history, molecular detection methods, chest computed tomography (CT), and clinical symptoms. […] We report the epidemiology, radiological characteristics, treatment, and clinical outcomes of these patients. […] In the first admission diagnosis, according to the degree of clinical symptoms, the 8 patients were defined as mild type (4/8) or moderate type (4/8). […] In this group of COVID-19 patients, half of the patients showed occult clinical manifestations and negative CT performance. | 2020-07-11 |
| 32647807 | To date, preliminary evidence from case series is favorable as significant clinical, biochemical improvement and hospital discharge have been reported. […] Emerging risk stratification algorithms integrating clinical and biochemical markers to trace the cases at risk of significant deterioration can prove valuable in this direction. | 2020-07-11 |
| 32647915 | Demographic and clinical data, 28-day outcomes, in-hospital complications and CRB-65 scores of COVID-19 patients in the two hospitals were analysed. | 2020-07-11 |
| 32648093 | Demographic data, laboratory parameters, treatments and clinical outcomes of the patients were collected and analyzed. | 2020-07-11 |
| 32648245 | In this sense, mesenchymal stem cells may improve the patient’s clinical and immunological response to COVID-19. | 2020-07-11 |
| 32648254 | Translational simulation - simulation that is integrated and focused on emerging clinical priorities - offers numerous opportunities to aid in pandemic preparation. | 2020-07-11 |
| 32648280 | The COVID-19 pandemic lead scientists and governmental authorities to issue clinical and public health recommendations based on progressively emerging evidence and expert opinions and many of these fast-tracked to peer-reviewed publications. | 2020-07-11 |
| 32648313 | Some patients with COVID-19 develop severe clinical manifestations, while others show mild symptoms, suggesting that dysregulation of the host immune response contributes to disease progression and severity. […] This may help us to understand the immune status of patients with COVID-19, particularly those with severe clinical presentation, and form a basis for further immunotherapeutic investigations. | 2020-07-11 |
| 32648389 | Combined with previous clinical experience in anti-epidemic and acupuncture, the prevention program of fire needling therapy for coronavirus disease 2019 (COVID-19) was drawn out. | 2020-07-11 |
| 32648578 | The unsynchronized changes in the clinical symptoms and COVID-19 nucleic acid were found in this case, so consecutive nucleic acid detection of pretty suspected cases was recommended. | 2020-07-11 |
| 32648667 | The COVID-19 pandemic changed health-care operations around the world and has interrupted standard clinical practices as well as created clinical research challenges for cancer patients. […] In addition, the pandemic has resulted in risks to health-care workers and research staff driving important change in clinical research operations and procedures. […] Remote telephone and video visits, remote monitoring, electronic capture of signatures and data, and limiting sample collections have allowed the leadership in our institution to ensure the safety of our staff and patients while continuing critical clinical research operations. […] Here we discuss some of these unique challenges and our response to change that was necessary to continue cancer clinical research; and, the impacts the pandemic has caused including increases in efficiency for our cancer research office. | 2020-07-11 |
| 32648899 | The average time from exposure to symptom onset is 5 days, and 97.5% of people who develop symptoms do so within 11.5 days. […] The most common symptoms are fever, dry cough, and shortness of breath. […] Approximately 5% of patients with COVID-19, and 20% of those hospitalized, experience severe symptoms necessitating intensive care. […] Advances in prevention and effective management of COVID-19 will require basic and clinical investigation and public health and clinical interventions. | 2020-07-11 |
| 32648950 | Clinical care delivery was reported as negatively affected in 28% of centers. | 2020-07-11 |
| 32648959 | Improvement of clinical symptoms, assessed by need for respiratory support (1 RCT, 103 participants; 1 controlled NRSI, 195 participants) We are very uncertain whether convalescent plasma has any effect on improvement of clinical symptoms at seven days (RCT: RR 0.98, 95% CI 0.30 to 3.19), 14 days (RCT: RR 1.85, 95% CI 0.91 to 3.77; controlled NRSI: RR 1.08, 95% CI 0.91 to 1.29), and 28 days (RCT: RR 1.20, 95% CI 0.80 to 1.81; very low-certainty evidence). | 2020-07-11 |
| 32649222 | Patients were divided into groups based on their clinical outcome: non-survivors vs. survivors and patients admitted to intensive care unit vs. others. | 2020-07-11 |
| 32649229 | Conclusions - Clinical specimens exhibit a wide range of viral burden, with a significant portion at low levels. | 2020-07-11 |
| 32649232 | This practical guidance, endorsed by the Brazilian Society of Thrombosis and Hemostasis and The Brazilian Society of Angiology and Vascular Surgery, the International Union of Angiology and the European Venous Forum, aims to provide physicians with clear guidance, based on current best evidence-based data, on clinical strategies to manage antithrombotic strategies in patients with coronavirus disease 2019. | 2020-07-11 |
| 32649262 | Aim of this communication is to remind clinical professionals to be aware of ototoxic side effects of several specific drugs proposed for the treatment of the new virus SARS-CoV-2 (Covid-19). | 2020-07-11 |
| 32649264 | Authors of the previously published article provide a brief synopsis that emphasizes important new information such as technological advances, revised imaging protocols, new clinical guidelines involving imaging, or updated classification schemes. | 2020-07-11 |
| 32649266 | Background: The (COVID-19) pandemic resulted in sudden disruption of routine clinical care necessitating rapid transformation to maintain clinical care while safely reducing virus contagion. […] Discussion: Clinical, Information Technology (IT), and hospital system barriers were successfully addressed for most cancer patients seeking individual telehealth treatment. | 2020-07-11 |
| 32649272 | Several aspects of this infectious disease mimic metabolic events shown to occur during latent subclinical magnesium deficiency. […] Hypomagnesemia is a relatively common clinical occurrence that often goes unrecognized since magnesium levels are rarely monitored in the clinical setting. […] The National Academy of Medicine’s Standards for Systematic Reviews were independently employed to identify clinical and prospective cohort studies assessing the relationship of magnesium with interleukin-6, a prominent drug target for treating COVID-19. […] Clinical recommendations are given for prevention and treatment of COVID-19. […] The peer-reviewed literature supports that several aspects of magnesium nutrition warrant clinical consideration. | 2020-07-11 |
| 32649367 | Subsequently, patients with the most severe symptoms tend to have poor outcomes, manifest severe hypoxia, and possess elevated levels of pro-inflammatory cytokines (including IL-1β, IL-6, IFN-γ, and TNF-α) along with elevated levels of the anti-inflammatory cytokine IL-10, marked lymphopenia, and elevated neutrophil-to-lymphocyte ratios. […] Finally, novel management approaches, clinical trials, and therapeutic strategies toward both SARS-CoV-2 and COVI-Flu infection are discussed, highlighting host response optimization and systemic inflammation reduction. | 2020-07-11 |
| 32649505 | In the second case, the patient remained at home with mild symptoms, starting at 20 weeks of gestation. | 2020-07-11 |
| 32649538 | The various symptoms identified for COVID-19 are fever, dry cough, sore throat, dyspnea, fatigue, myalgia, and headache. | 2020-07-11 |
| 32649560 | This article outlines new guidelines for infection prevention: from clinical control, treatment processes, clinical management, protection, and disinfection of healthcare professionals. | 2020-07-11 |
| 32649738 | Early prediction of survival of hospitalized patients will help the clinical management of COVID-19, but such a prediction model which is reliable and valid is still lacking. […] A nomogram based on the three variables was built for clinical use. | 2020-07-11 |
| 32649743 | We aimed to determine overall seroprevalence rates by age group, reported symptoms, contact exposure and to explore dynamics of transmission. […] Within antibody positive individuals, 40% of students and 18% of staff reported no symptoms (P=0.01). | 2020-07-11 |
| 32649747 | Hospitalized patients with COVID-19 experiencing respiratory symptoms have different complications (inflammatory, co-infection and thrombotic) that are identifiable by analytics patterns. | 2020-07-11 |
| 32649784 | Our aim was to describe the clinical features of mothers infected with COVID-19 and examine any potential vertical mother to newborn transmission. […] We reviewed the medical records of 42 pregnant women diagnosed with COVID-19 from March 13, 2020, to March 29, 2020, when they were in their third trimester of pregnancy. […] The initial clinical symptoms were coughing (66.6%) and fever (59.5%), and one mother died due to thrombo-embolic events. | 2020-07-11 |
| 32649791 | Clinical presentation, laboratory values, immunosuppression and treatment strategies were reviewed and predictors of poor clinical outcomes were determined through multivariable analyses. | 2020-07-11 |
| 32649864 | Clinical studies of patients with COVID-19 have shown that gastrointestinal disorders appear to precede or follow the respiratory symptoms. […] Here, we review gastrointestinal disorders in patients with COVID-19, suggest hypothetical mechanisms leading to gut symptoms, and discuss the potential consequences of gastrointestinal disorders on the outcome of the disease. | 2020-07-11 |
| 32649962 | This observation likely explains the multitude of symptoms that have been described from human patients. | 2020-07-11 |
| 32650004 | Severe coronavirus disease 2019 (COVID-19) symptoms, including systemic inflammatory response and multisystem organ failure, are now affecting thousands of infected patients and causing widespread mortality. […] Soluble epoxide hydrolase (sEH) inhibitors, which increase endogenous epoxyeicosatrienoic acid levels, exhibit potent anti-inflammatory activity and inhibit various pathologic processes in preclinical disease models, including pulmonary fibrosis, thrombosis, and acute respiratory distress syndrome. […] In this review, we discuss the predominant role of eicosanoids in regulating the inflammatory cascade and propose the potential application of sEH inhibitors in alleviating COVID-19 symptoms. […] Future studies determining the eicosanoid profile in COVID-19 patients or preclinical models are pivotal in providing novel insights into coronavirus-host interaction and inflammation modulation. | 2020-07-11 |
| 32650037 | Currently, a reverse-transcription polymerase chain reaction (RT-PCR) assay is used to detect the virus in clinical laboratories. | 2020-07-11 |
| 32650110 | Olfactory dysfunction occurred suddenly, either as first complaint or preceded by mild symptoms occurring a median of 3 days. | 2020-07-11 |
| 32650189 | EMA decided that with ulipristal acetate (UPA) treatment for uterine fibroids, should be discontinued due to the associated risk of hepatic failure, We analyzed whether the risk of recurrent symptoms due to fibroids may lead to an increased risk of Covid -19 infection and death, that would exceed the former risk of hepatic failure and transplantation. […] Our calculations suggest that the decision to stop UPA in the middle of the Covid- 19 pandemic may be untimely, since it may result in an increased risk of Covid-19 infection, due to the recurrence of symptoms and the need for medical and surgical treatment. | 2020-07-11 |
| 32650275 | We used two comprehensive 11-colour flow cytometric panels conforming to Good Laboratory Practice and approved for clinical diagnostics. […] Absolute numbers of lymphocyte subsets were differentially decreased in COVID-19 patients according to clinical severity. […] Understanding T cell-responses in the context of clinical severity might serve as foundation to overcome the lack of effective anti-viral immune response in severely affected COVID-19 patients and can offer prognostic value as biomarker for disease outcome and control. | 2020-07-11 |
| 32650305 | Understanding the occurrence of symptoms resembling those of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a large nonhospitalized population at the peak of the epidemic in Italy is of paramount importance; however, data are currently scarce. […] The aims of this study were to evaluate the association of self-reported symptoms with SARS-CoV-2 nasopharyngeal swab (NPS) test results in nonhospitalized individuals and to estimate the occurrence of symptoms associated with coronavirus disease (COVID-19) in a larger nontested population. […] The associations between symptoms potentially related to SARS-CoV-2 infection and NPS results were calculated as adjusted odds ratios (aORs) with 95% CIs by multiple logistic regression analysis controlling for age, sex, education, smoking habits, and number of comorbidities. […] Thereafter, for each symptom and for combinations of the symptoms, we calculated the sensitivity, specificity, accuracy, and areas under the curve (AUCs) in a receiver operating characteristic (ROC) analysis to estimate the occurrence of COVID-19-like infection in the nontested population. […] Having two to four of these symptoms increased the aOR from 7.4 (95% CI 5.6-9.7) to 35.5 (95% CI 24.6-52.2). […] The combination of the four symptoms showed an AUC of 0.810 (95% CI 0.795-0.825) in classifying positive NPS test results and then was applied to the nonhospitalized and nontested sample (n=165,782). […] We found that 7739 to 20,103 of these 165,782 respondents (4.4% to 12.1%) had experienced symptoms suggestive of COVID-19 infection. […] Our results suggest that self-reported symptoms are reliable indicators of SARS-CoV-2 infection in a pandemic context. | 2020-07-11 |
| 32650354 | Finally, their physicians must promptly manage any medical signs or symptoms in the case of suspected severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) infection to prevent the risk of severe outcomes. | 2020-07-11 |
| 32650355 | However, there is a lack of clinical evidence to support the use of these agents, indicating that further randomized controlled studies are required. | 2020-07-11 |
| 32650356 | We can distinguish three clinical phases of the disease with a distinct pathogenesis, manifestations and prognosis. […] His condition improved, and in the ensuing days, the treatment gradually switched to a high-flow nasal cannula (HFNC); after 18 days, the patient’s clinical condition was good.The successful results we have been able to obtain are closely associated with avoidance of invasive ventilation that may lead to intensive care unit (ICU)-related superinfections. | 2020-07-11 |
| 32650509 | Through a recent upsurge of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, the clinical assessment of most of the coronavirus disease 19 (COVID-19) patients clearly presents a health condition with the loss of oro-naso-sensory (ONS) perception, responsible for the detection of flavor and savor. […] In some cases, these clinical manifestations appear even before the general flu-like symptoms, e.g., sore throat, thoracic oppression and fever. […] Hence, obesity represents a great risk factor for SARS-CoV-2 infection, as it may hide the viral-associated altered ONS symptoms, thus leading to a high mortality rate in these subjects. | 2020-07-12 |
| 32650522 | About 41% reported symptoms associated with mild anxiety; 23.1% reported moderate-severe anxiety symptoms. […] Concerning depression, 48% reported mild and 9.2% moderate-severe depression symptoms. […] Women, younger age (18-29), student status, unemployment status, prior psychiatric history, and those reporting greater negative impact on their QOL, were at higher risk for increased anxiety and depression symptoms (p < 0.05). | 2020-07-12 |
| 32650672 | By February 2020, cases had been identified in multiple countries, clinical trials of treatments with some biological plausibility had begun in China, and the initial steps of vaccine development were underway. […] The urgency of finding ways to treat, and ultimately prevent, the consequences of this new and potentially deadly infection has led to unprecedented focus on clinical trials. | 2020-07-12 |
| 32650675 | We review the data and understanding around the virus related to the digestive tract, impact of the pandemic on delivery of GI services and daily gastroenterology clinical practice, and the effects on patients with pre-existing GI diseases. | 2020-07-12 |
| 32650681 | Other differences related to knowledge of COVID-19 were symptoms, treatment, ways of spreading (p < .001), prevention by avoiding crowded places (p = .008) and isolation (p = .002). […] For attitudinal items, normal participants generally showed more positive attitudes than the fatigued in believing that COVID-19 will finally be controlled, satisfaction with preventive measures taken by the authorities, reporting suspected cases with symptoms and trusting that Turkey can overcome the COVID-19 pandemic (p < .001). | 2020-07-12 |
| 32650753 | Dentists also need to take new precautions during their clinical activity to protect themselves, coworkers and patients from the risks of contagion and to avoid further spread of infection. | 2020-07-12 |
| 32650756 | The importance of a thorough clinical handover cannot be overstated and regulatory bodies are needed to prevent what can be considered unethical procedure towards returning cancer patients with lack of an effective handover. | 2020-07-12 |
| 32650785 | This study explored the influence of altruism on negative affect and mental health (anxiety and depressive symptoms) during the COVID-19 pandemic while people self-isolated at home in China. […] Self-reported perceived risk, altruism, negative affect, anxiety and depressive symptoms were measured using the Self-Report Altruism Scale (SRA scale), the Positive and Negative Affect Schedule (PANAS), the 7-item Generalized Anxiety Disorder Scale (GAD-7) and the 9-item Patient Health Questionnaire depression scale (PHQ-9). […] Individuals with high altruism exhibited more negative affect than those with low altruism, which indirectly increased their anxiety and depressive symptoms. | 2020-07-12 |
| 32650818 | Patients can only be included within 3 days of symptom onset in ambulatory care if they consent to the study procedure and are able to adhere to the study visit schedule and protocol requirements (including telephone visits concerning symptoms and side effects). | 2020-07-12 |
| 32650948 | Eighteen semen samples from recovered men were obtained 8-54 days after absence of symptoms, 14 from control subjects, and 2 from patients with an active COVID-19 infection. | 2020-07-12 |
| 32650954 | Ten percent reported a worsening of urological symptoms during confinement. | 2020-07-12 |
| 32651031 | Since the pandemic began, the global healthcare community has accumulated invaluable clinical experience on providing diabetes care in the setting of COVID-19. […] The current clinical management of diabetes is a work in progress, requiring a shift in patient-provider interaction beyond the walls of clinics and hospitals: the use of tele-medicine when feasible, innovative patient education programs, strategies to ensure medication and glucose testing availability and affordability, as well as numerous ideas on how to improve meal plans and physical activity. | 2020-07-12 |
| 32651067 | ARB or ACEI treatment was not associated with a worse clinical outcome in consecutive hypertensive patients infected by SARS-CoV-2. | 2020-07-12 |
| 32651152 | To evaluate the factors associated with false negatives in RT-qPCR in patients with mild-moderate symptoms of COVID-19. […] Information regarding symptoms was collected and all patients were simultaneously tested using two rapid diagnostic tests - RDTs (Combined - cRDT and Differentiated - dRDT). […] The association between symptoms and SARS-CoV-2 infection was evaluated by non-conditional logistic regression, with estimation of Odds Ratio. […] Fever over 38°C (present in 35.5% of cases) and anosmia (present in 41.8%) were the symptoms most associated with SARS-CoV-2 infection, a relationship that remained statistically significant in patients with negative RT-qPCR and some positive RDT (aOR=6.64; 95%CI=1.33-33.13 and aOR=19.38; 95% CI=3.69-101.89, respectively). […] Our results show that patients who present mild or moderate symptoms with negative RT-qPCR, but with fever and/or anosmia, should be considered as suspicious cases and should be evaluated with other diagnostic methods. | 2020-07-12 |
| 32651176 | Adoption of new methods should be based on clinical judgement, the weight of evidence and the balance of probabilities that any new technique, test or treatment might work. | 2020-07-12 |
| 32651252 | The empirical questions pertain to the available level of evidence that healthcare professionals would rather not be left alone with their ‘clinical judgments’ to make triage decisions, and to the accounts of distributive justice that doctors and healthcare professionals rely on, when making triage decisions. […] This debate goes beyond the discussion of the care of critically ill patients with COVID-19 and has broader implications beyond the national context for the discussion of how to relieve moral distress in contexts of imbalances between healthcare resources and clinical needs of a population. | 2020-07-12 |
| 32651306 | This study aims to analyze the epidemiological and clinical features of coronavirus disease 19 (COVID-19) in a Moroccan pediatric population. […] We collected information on clinical and laboratory features of all children (age <18 years) admitted between 2 March, 2020 and 1 April, 2020. | 2020-07-12 |
| 32651326 | In addition, there has been disruption to clinical care and clinical research. […] This pandemic might have significantly changed the care for our patients with dementia toward increased acceptance of telemedicine by the patients and providers, and its utilization in both clinical care and research. | 2020-07-12 |
| 32651328 | The COVID-19 pandemic is changing clinical practice in neurology, after the governments decided the introduction of social distancing and interruption of medical non-emergency services in many countries. […] A structured questionnaire and Clinical Dementia Rating Scale (CDR)-FTD were used by the neurologist with patients and/or caregivers. […] Index symptoms of COVID-19 infection were searched. […] Twenty-eight clinical interviews were completed with caregivers and four with both patients/caregivers. […] Fifty percent of patients experienced significant worsening of clinical picture and quality of life since the start of social distancing. […] One patient presented index symptoms of COVID-19 infection and was confirmed to be positive for COVID-19 with pharyngeal swab. | 2020-07-12 |
| 32651556 | The recent spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exemplifies the critical need for accurate and rapid diagnostic assays to prompt clinical and public health interventions. […] Currently, several quantitative reverse transcription-PCR (RT-qPCR) assays are being used by clinical, research and public health laboratories. | 2020-07-12 |
| 32651579 | These conditions include thrombotic complications, myocardial dysfunction and arrhythmia, acute coronary syndromes, acute kidney injury, gastrointestinal symptoms, hepatocellular injury, hyperglycemia and ketosis, neurologic illnesses, ocular symptoms, and dermatologic complications. | 2020-07-12 |
| 32651712 | The education times for lecture and clinical case discussion were decreased during the pandemic (both, p < 0.001), respectively. | 2020-07-12 |
| 32651717 | Between 11 and 73.4% of HCWs, mainly including physicians, nurses, and auxiliary staff, reported post-traumatic stress symptoms during outbreaks, with symptoms lasting after 1-3 years in 10-40%. […] Depressive symptoms are reported in 27.5-50.7%, insomnia symptoms in 34-36.1%, and severe anxiety symptoms in 45%. […] General psychiatric symptoms during outbreaks have a range comprised between 17.3 and 75.3%; high levels of stress related to working are reported in 18.1 to 80.1%. | 2020-07-12 |
| 32651736 | Clinical data about these patients is scarce. […] We aimed to evaluate the clinical findings of patients with COVID-19 who have increased leukocyte at admission. […] We retrospectively collected the clinical data on the 52 patients who have increased leukocyte count at admission from the 619 patients with confirmed COVID-19 who had pneumonia with abnormal features on chest CT scan in Renmin Hospital of Wuhan University in Wuhan, China, from February 3 to March 3, 2020. | 2020-07-12 |
| 32651741 | Our results suggest that these distinct gene expression profiles, detected early after infection by these two coronaviruses, may help us understand the differences in clinical outcomes of MERS-CoV and SARS-CoV-2 infections. | 2020-07-12 |
| 32651894 | Neither operator, nor patient have developed Covid symptoms. | 2020-07-12 |
| 32651936 | It improved the clinical symptoms of patients, reduced the mortality rate, improved the recovery rate, and effectively relieved the operating pressure on the national medical system during critical conditions. | 2020-07-12 |
| 32651938 | Little is known regarding coronavirus disease 2019 (COVID-19) clinical spectrum in non-Asian populations. […] We retrospectively assessed liver function tests, taking into account demographic characteristics and clinical outcome. | 2020-07-12 |
| 32651941 | In this review, we analyze pertinent clinical remdesivir data for patients with COVID-19 from January 1, 2020, through May 31, 2020. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32652021 | However, its clinical value in COVID-19 patients evaluation was unclear. […] Demographic and clinical data were collected. | 2020-07-12 |
| 32652139 | The main complication of coronavirus disease 2019 (COVID-19) is respiratory failure, but several patients have also been admitted to the hospital with neurological symptoms. | 2020-07-12 |
| 32652164 | A 1:2 matching to patients not treated with TCZ was performed according to age, sex, severity of disease, P/F, Charlson Comorbidity Index and length of time between symptoms onset and hospital admittance. | 2020-07-12 |
| 32652215 | The clinical best care practices (CBPs) of hand hygiene, hygiene and sanitation, screening, and basic and additional precautions aim to reduce this burden. | 2020-07-12 |
| 32652240 | The aim of this study was to evaluate the analytical and clinical performance of the VIASURE SARS-CoV-2 S gene RT-PCR Kit on the BD Max™ system and to compare results with those obtained with the cobas® SARS-CoV-2 test on the cobas® 6800 system. […] Clinical samples (n = 101) obtained from individuals with symptoms compatible with COVID-19 were studied. […] Six out of the 101 clinical samples (5.9%) showed an inhibition with the VIASURE test. […] When analysing the remaining 95 clinical samples, 27 were found to be negative with both assays. | 2020-07-12 |
| 32652443 | We investigated the medical records on the number of cancer diagnosis, cancer surgery, radiation therapy and scheduled chemotherapy conducted in Korea University Anam Hospital from January 1 to April 30, 2019 and from the same period in 2020. | 2020-07-12 |
| 32652454 | The purpose of this study was to investigate the chest CT imaging features and clinical outcome of coronavirus disease 2019 (COVID-19) in Ningbo, China. | 2020-07-12 |
| 32652455 | The purpose of this brief review is to summarize such training and education for clinical management of this outbreak for radiology department personnel. | 2020-07-12 |
| 32652476 | A comparative limit of detection (LoD) assessment was performed between RealStar® SARS-CoV-2 and the currently WHO recommended RT-PCR (WHO-PCR) workflow using a quantified clinical sample. […] Assessment of the RealStar® SARS-CoV-2 assay was also performed using 83 primary clinical samples in comparison with the WHO-PCR. […] The overall percent agreement between RealStar® SARS-CoV-2 and WHO-PCR on 83 clinical samples was 97.6 % (81/83) with a sensitivity at 97.8 % (45/46) and specificity at 97.3 % (36/37). | 2020-07-12 |
| 32652499 | Early symptoms overlap with other common conditions such as common cold and Influenza, making early screening and diagnosis are crucial goals for health practitioners. […] The aim of the study was to use machine learning (ML), an artificial neural network (ANN) and a simple statistical test to identify SARS-CoV-2 positive patients from full blood counts without knowledge of symptoms or history of the individuals. […] Patient data was anonymised by the hospital, clinical data was standardized to have a mean of zero and a unit standard deviation. […] While symptoms at an early stage of infection are known to overlap with other common conditions, parameters of the full blood counts can be analysed to distinguish the viral type at an earlier stage than current rt-PCR tests for SARS-CoV-2 allow at present. | 2020-07-12 |
| 32652520 | Three weeks before the start of the neurological symptoms, the boy had experienced an episode of mild febrile illness with mild respiratory manifestations and a persistent cough. | 2020-07-12 |
| 32652521 | We collected information on the clinical characteristics and outcomes of a cohort of 29 children (16 females and 13 males, median age 7 years, range [0-16]) diagnosed with SARS-CoV-2 infection while on chemotherapy/immunotherapy (N=26), or after stem cell transplantation (N=3) during the peak of the epidemic in Italy. […] The course of the disease was mild in all cases, with only 12 children developing symptoms (pneumonia in 3 cases), and none needing intensive care. […] Nine patients (including 5 with no symptoms) were given hydroxychloroquine, and 3 of them were also given lopinavir/ritonavir. […] SARS-CoV-2 infection seems to take a milder clinical course in children than in adults with cancer. | 2020-07-12 |
| 32652660 | We employed a thorough strategy to identify subclinical COVID-19 disease, and after confirming the absence of active disease, proceeded with the CABG operation. | 2020-07-12 |
| 32652713 | We sought to systematically review the current published literature on the different cardiac manifestations and the use of cardiac-specific biomarkers in terms of their prognostic value in determining clinical outcomes and correlation to disease severity. […] A systematic literature review across PubMed, Cochrane database, Embase, Google Scholar, and Ovid was performed according to PRISMA guidelines to identify relevant articles that discussed risk factors for cardiovascular manifestations, cardiac manifestations in COVID-19 patients, and cardiac-specific biomarkers with their clinical implications on COVID-19. | 2020-07-12 |
| 32652862 | Actions taken included launching remote access to clinical systems for all dosimetrists and physicists, establishing lines of communication among staff members, and altering coverage schedules to limit on-site presence and decrease risk of infection. | 2020-07-12 |
| 32652884 | To investigate the anxiety and depression levels of frontline clinical nurses working in 14 hospitals in Gansu Province, China, during this period. | 2020-07-12 |
| 32652912 | To estimate the prevalence of clinical symptoms associated with COVID-19 among people living with HIV (PLWH) in Tehran, Iran. […] Of 200 participants, respiratory symptoms, including cough, sputum, and shortness of breath, were the most prevalent among participants, but only one person developed symptoms collectively suggested COVID-19 and sought treatments. | 2020-07-13 |
| 32653015 | Hydroxychloroquine and lopinavir/ritonavir have potential interest, but virological and clinical data are scarce, especially in critically ill patients. | 2020-07-13 |
| 32653040 | We argue that higher-quality evidence is necessary to understand the protective effect of the BCG vaccine from existing, secondary data, while we await results from clinical trials currently conducted in different settings. | 2020-07-13 |
| 32653054 | We aimed to describe the clinical characteristics, course, management, and outcomes of patients admitted to PICUs with this condition, which is now known as paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS). […] We analysed routinely collected, de-identified data, including demographic details, presenting clinical features, underlying comorbidities, laboratory markers, echocardiographic findings, interventions, treatments, and outcomes; serology information was collected if available. […] Clinical presentations and treatments varied. | 2020-07-13 |
| 32653111 | We used the American Clinical Neurophysiology Society’s terminology for the description of abnormal patterns. […] Medical records were reviewed to extract demographics, clinical, imaging and biological data. | 2020-07-13 |
| 32653160 | The goal of this study was to clarify the clinical characteristics of recovery and death in patients with severe or critical COVID-19. […] In this retrospective single-center study, clinical data were collected from 74 severe or critical COVID-19 patients in Wuhan Fourth Hospital between Jan. 25th and Feb. 26th, 2020. […] All patients were divided into a recovery group or a death group according to clinical outcomes, and the differences between the groups were compared. | 2020-07-13 |
| 32653224 | Several countries started clinical trials of the BCG vaccine for health care workers and elderly people. | 2020-07-13 |
| 32653383 | Since novel coronavirus disease (COVID-19) emerged, various clinical features of COVID-19 have been reported. […] We conducted a systematic review of published studies reporting the clinical features of COVID-19. […] A meta-analysis was performed to measure the frequencies of clinical outcomes and symptoms of COVID-19. […] Both fever and cough were major symptoms, and their frequencies were higher in Group I than in Groups II and III, while the frequency of diarrhea in Group I was lower than that in Group III. […] The trends in the clinical features of COVID-19 changed from December 2019 to February 2020. […] During this observation period, as the infection continued to spread, the clinical conditions for majority of patients became less severe with the changes in the route of transmission. | 2020-07-13 |
| 32653423 | Demographic, clinical, laboratory, radiologic, treatments, complications, and clinical outcomes data were extracted from electronic medical records and compared between diabetes (n = 84) and nondiabetes (n = 500) groups. […] In terms of complications and clinical outcomes, the incidence of respiratory failure (36.9% vs 24.2%, P = .022), acute cardiac injury (47.4% vs 21.2%, P < .01), and death (20.2% vs 8.0%, P = .001) in the diabetes group was significantly higher than that in the nondiabetes group. | 2020-07-13 |
| 32653470 | The novel severe acute respiratory syndrome coronavirus 2 virus that emerged in December 2019 causing coronavirus disease 2019 (COVID-19) has led to the sudden national reorganization of health care systems and changes in the delivery of health care globally. | 2020-07-13 |
| 32653479 | The majority of participants had a good level of knowledge of common symptoms, transmission, and prevention of the disease. | 2020-07-13 |
| 32653486 | In this retrospective study, we collected the first clinical laboratory data of 114 patients on admission, and 80 healthy controls. | 2020-07-13 |
| 32653511 | Studies have shown that infection, excessive coagulation, cytokine storm, leukopenia, lymphopenia, hypoxemia and oxidative stress have also been observed in critically ill Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) patients in addition to the onset symptoms. | 2020-07-13 |
| 32653530 | In this brief review, we discuss the effect of ACE inhibitor-induced bradykinin on the cardiovascular system, on the renin-angiotensin-aldosterone system (RAAS) regulation in COVID-19 patients, and analyze recent clinical studies regarding patients treated with RAAS inhibitors. | 2020-07-13 |
| 32653568 | By following established protocols and considering medical history, clinical manifestations, and laboratory markers, this system might help to evaluate the severity of COVID-19 remotely. | 2020-07-13 |
| 32653618 | Two groups were investigated: 1) 12 082 individuals already proven positive for SARS-CoV-2 (clinical information was studied); 2) 7864+4458 individuals with suspected respiratory infections (polymerase chain reaction [PCR] tests and clinical information were studied). | 2020-07-13 |
| 32653627 | A recent multicenter study carried out by the Hubei Anti-Cancer Association has also documented that patients with lung cancer had an increased risk of death, intensive care unit requirement, risk of presenting severe or critical symptoms, and use of invasive mechanical ventilation. | 2020-07-13 |
| 32653662 | Asymptomatic patients, together with those with mild symptoms of coronavirus disease 2019 (COVID-19), may play an important role in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. […] However, the dynamics of virus shedding during the various phases of the clinical course of COVID-19 remains unclear at this stage. […] A total of nine (50%) asymptomatic patients and nine (50%) patients with mild symptoms of COVID-19 were identified at admission. […] Six patients (66.7%) who were asymptomatic at admission developed subjective symptoms during hospitalization and were recategorized as being presymptomatic. […] Long-term virus shedding was documented in patients with mild symptoms and in asymptomatic patients. […] These observations should be considered when making decisions regarding clinical and public health, and when considering strategies for the prevention and control of SARS-CoV-2 infection. | 2020-07-13 |
| 32653775 | However, there has been no framework in most countries for integrated decision-making that takes into account the requirements of public health, clinical medicine and palliative and end-of-life care. | 2020-07-13 |
| 32653961 | Chest imaging is recommended for triage of suspected cases of COVID-19 with moderate-severe clinical features and high pre-test probability of disease, and may help for patient follow-up and to identify patients at higher risk of disease worsening. | 2020-07-13 |
| 32653981 | Among the clinical manifestations of COVID-19, the disease that results from SARS-CoV-2 infection in humans, a prominent feature is a pro-thrombotic derangement of the hemostatic system, possibly representing a peculiar clinicopathologic manifestation of viral sepsis. […] This review is particularly focused on four clinical questions: What is the incidence of VTE in COVID-19 patients? […] In the complex scenario of an overwhelming pandemic, most everyday clinical decisions have to be taken without delay, although not yet supported by a sound scientific evidence. […] This review discusses the most recent findings of basic and clinical research about the COVID-associated coagulopathy, to foster a more thorough knowledge of the mechanisms underlying this compelling disease. | 2020-07-13 |
| 32653986 | The two groups did not differ in clinical parameters including age (COVID-19 59.4 vs. non-COVID-19 58.1 years), gender (36.4% vs. | 2020-07-13 |
| 32654006 | Hospital mortality at 40% remains unacceptably high underlining the need to continue to develop and test therapies for this devastating clinical condition. […] We also critically assess drugs that demonstrate potential in emerging reports from clinical studies in patients with COVID-19-induced ARDS. […] Several therapies show promise in earlier and later phase clinical testing, while a growing pipeline of therapies is in preclinical testing. […] The history of unsuccessful clinical trials of promising therapies underlines the challenges to successful translation. | 2020-07-13 |
| 32654049 | For treatment of solid tumor patients, if they did not have symptoms related to COVID-19, just chest X-ray was requested. […] If they showed COVID-19 related symptoms, high resolution CT scan of lungs was requested. | 2020-07-13 |
| 32654065 | There was a significant increase of psychological distress and symptoms of mental illness, and worsening of quality of sleep in the general population. […] Participants completed an anonymous web-based survey that include questionnaires about sleep and anxiety and depression symptoms. […] Our sample included 400 subjects: 307 students (mean age 22.84 ± 2.68) and 93 university administration staff workers (mean age 37.02 ± 12.46). we found an increase in Bed Time hour, Sleep Latency, and Wake-Up time between before and during COVID-19 emergency and a worsening of sleep quality and of insomnia symptoms. […] In our sample, 27.8% showed depressive symptoms, while 34.3% showed anxious symptoms, in particular in students. […] Concerning the psycho-emotional aspects, about one-third of our sample showed depressive or anxious symptoms. | 2020-07-13 |
| 32654078 | More research in the field is obviously required, including as a minimum careful and systematic epidemiology and appropriately controlled clinical trials. | 2020-07-13 |
| 32654082 | We identified various histopathology reports and clinical case series reporting thromboses in COVID-19. | 2020-07-13 |
| 32654210 | However, evidence showed that, even if the prevalence of COVID-19 damage consists in pulmonary lesions and symptoms, it could also affect other organs, such as heart, liver, and spleen. […] Particularly, some infected patients refer to the emergency department for cardiovascular symptoms, and around 10% of COVID-19 victims had finally developed heart injury. | 2020-07-13 |
| 32654244 | Scarce data are available on the optimized management of ISDs in these patients and on its impact on presentation, clinical course, viral shedding, and outcome. | 2020-07-13 |
| 32654267 | This review presents a report on the origin, transmission, symptoms, diagnosis, possible vaccines, animal models, and immunotherapy for this novel virus and will provide ample references for the researchers toward the ongoing development of therapeutic agents and vaccines and also preventing the spread of this disease. | 2020-07-13 |
| 32654303 | COVID-19 infection varies in severity from minimal symptoms to critical illness associated with a hyperinflammatory response. […] We examined the electronic medical records of all SOT recipients with COVID-19 from 12 Massachusetts hospitals between February 1, and May 6, 2020. […] We analyzed the demographics, clinical parameters, course, and outcomes of illness in these patients. […] The clinical course and trend of laboratory biomarkers is biphasic with a later, pronounced peak in inflammatory markers seen in those admitted to an ICU. | 2020-07-13 |
| 32654332 | The clinical characteristics of 47 SOTr (38 kidneys and 9 nonkidney organs) were compared to 100 consecutive hospitalized nontransplant controls. […] Multivariate analysis demonstrated that increasing age and clinical severity were associated with mortality. | 2020-07-13 |
| 32654350 | Significantly reduced NC and INT monocytes and a downregulated HLA-DR were found in acute patients with severe SARS-CoV-2 symptoms. […] Conversely in patients with moderate symptoms NC and INT monocytes and CD11b expression were increased. | 2020-07-13 |
| 32654357 | However, the incidence, clinical course, outcome, and predictive factors of disease severity are obscured. […] We describe clinical and laboratory manifestations, radiologic findings, clinical course, and finally outcome of kidney transplant recipients with COVID-19 pneumonia. […] Treatment with cyclosporine was associated with better clinical outcome. | 2020-07-13 |
| 32654359 | No patient had clinical symptoms of liver disease or signs of liver failure before and during hospitalization; for each of them liver function tests were available. […] Our preliminary results confirm the clinical impression that liver failure is not a main concern and this organ is not the target of significant inflammatory damage. | 2020-07-13 |
| 32654378 | Susceptibility to viral infection, development of immunity, response to treatment and patient clinical outcomes are all under the control of heritable factors in the host. | 2020-07-13 |
| 32654417 | Prioritization and additional safety measures were introduced into clinical practice. | 2020-07-13 |
| 32654489 | Using Amazon’s AWS computing resources and a network-based, deep-learning framework, we identified 41 repurposable drugs (including dexamethasone, indomethacin, niclosamide, and toremifene) whose therapeutic associations with COVID-19 were validated by transcriptomic and proteomics data in SARS-CoV-2-infected human cells and data from ongoing clinical trials. | 2020-07-14 |
| 32654611 | In 19 of 20 individuals with PCR-proven infection and only mild to moderate symptoms not requiring hospitalization positive IgG levels occurred within two to three weeks. | 2020-07-14 |
| 32654633 | Future clinical interventions should aim to reconnect dissociated parts both in the individual and in society. | 2020-07-14 |
| 32654656 | Although most infected persons are asymptomatic or have only mild symptoms, some patients progress to devastating disease; such progression is difficult to predict or identify in a timely manner. | 2020-07-14 |
| 32654740 | We report the clinical history, laboratory findings, and imaging features of coronavirus disease 2019 (COVID-19) in a neonate whose mother was also a patient. | 2020-07-14 |
| 32654801 | Telemedicine provides remote clinical support using technological tools. […] Telemedicine refers to the use of electronic information and telecommunications tools to provide remote clinical health care support. […] Telemedicine facilitates specialized urological clinical support at a distance, solves problems of limitations in mobility, reduces unnecessary visits to clinics, and is useful for reducing the risk of viral transmission in the current COVID-19 outbreak. […] Telemedicine in urology offers specialized remote clinical support to patients, similar to face-to-face visits. | 2020-07-14 |
| 32654921 | To describe the clinical and respiratory characteristics of a cohort of 43 patients with COVID-19 after an evolutive period of 28 days. | 2020-07-14 |
| 32655013 | We search Ovid MEDLINE, EMBASE, and the Cochrane Library for eligible publications reporting the clinical characteristics of patients with COVID-19 without language restriction. | 2020-07-14 |
| 32655021 | Patients were evaluated for demographic characteristics, clinical and laboratory data and findings of initial chest computed tomography (CT) and were followed until either death or discharge occurred. […] Clinical symptoms were similar to those of non-CKD individuals. | 2020-07-14 |
| 32655128 | The goal of this study was to describe the clinical and epidemiological features of patients affected by SARS-CoV-2 and the preventive and management measures adopted at the National Hospital for Paraplegics (Toledo, Castilla-La Mancha, Spain) to minimize the risk of transmission of Covid-19. […] The clinical characteristics of our patients differed slightly from those observed in other studies published in the general population, with cough and asthenia being the most frequent symptoms, present in 69.2% and 38.5%, respectively. 100% of the infected patients did not present complications that required assistance in the Intensive Care Unit. | 2020-07-14 |
| 32655463 | About 36% of the participants reported moderate to severe psychological impact, 25% showed mild to severe levels of anxiety, 41% reported depressive symptoms, and 41% felt stressed. […] Women, young, and those who that lost their job during the health crisis showed the strongest negative psychological symptoms. | 2020-07-14 |
| 32655489 | Histological evidence is provided, while symptoms such as headache and vertigo are highlighted as CNS manifestations of COVID-19. […] Treatment of these symptoms is addressed with paracetamol being recommended as a possible, but not conclusive, treatment to some CNS symptoms. […] Histological evidence is also provided while symptoms such as anosmia and ageusia are characterized as PNS manifestations. […] Possible treatment options for these symptoms are then addressed as a major limitation, as anecdotal, and not conclusive evidence can be made. | 2020-07-14 |
| 32655490 | The most prominent symptoms of SARS-CoV-2 infection are respiratory. | 2020-07-14 |
| 32655581 | In this review, we summarize the current understanding of how NK cells respond in both early and late coronavirus infections, and the implication for ongoing COVID-19 clinical trials. | 2020-07-14 |
| 32655654 | Many viral respiratory infections can cause severe acute respiratory symptoms leading to mortality and morbidity. […] The development of vaccines for SARS-CoV-2 is ongoing and various clinical trials are currently underway around the world. | 2020-07-14 |
| 32655735 | This study aims to assess the validity and clinical utility of the lymphocyte-to-C-reactive protein (CRP) ratio (LCR), typically used for gastric carcinoma prognostication, versus the neutrophil-to-lymphocyte ratio (NLR) for predicting in-hospital outcomes in COVID-19. […] A high LCR at presentation might indicate impending clinical deterioration and the need for IMV. | 2020-07-14 |
| 32655741 | In our study, the use of the oXiris® filter decreased levels of inflammatory markers including interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP), and improved clinical outcomes in two out of three patients. | 2020-07-14 |
| 32655846 | Only 1 patient (close contact of a case) as part of the psoriasis analyzed group was tested and turned out to be positive for SARS-CoV-2, developing no symptoms during the observation period. […] The collected information may suggest that psoriasis, biotechnologically treated or not, cannot promote or aggravate the clinical trend of the SARS-CoV-2 infection, hence stopping systemic therapy in negative or clinically free SARS-CoV-2 patients is not recommended in general. | 2020-07-14 |
| 32656006 | We conducted a systematic review and included 16 case reports to summarize the transmission and pathology of 2019-nCoV, and clinical presentation, laboratory and imaging findings, and treatment in 2019-nCoV pneumonia. […] The use of lopinavir/ritonavir and remdesivir was associated with significant clinical improvement in severe pneumonia. […] Nonetheless, we need more randomized clinical trials (RCTs) and treatment guidelines for developing effective management of the 2019-nCoV and improve patient outcomes by reducing mortality in high-risk patients. […] We also need more clinical trials and management guidelines for the effective management of 2019-nCoV pneumonia. | 2020-07-14 |
| 32656033 | Many studies have described typical clinical manifestations such as fever, cough, fatigue, diarrhea, and nasal congestion. | 2020-07-14 |
| 32656044 | This treatment regimen was associated with a prompt resolution of respiratory failure, elimination of clinical manifestations of the cytokine release syndrome (CRS), and reversal of pulmonary CT changes. | 2020-07-14 |
| 32656050 | As the COVID-19 pandemic evolves, the medical community continues to discover novel clinical manifestations of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. […] This case emphasizes the importance of continued investigation regarding diagnosis and treatment of COVID-19 and its related symptoms. | 2020-07-14 |
| 32656087 | However, despite the necessity to assist a substantial number of affected patients, it is also essential to, at the same time, guarantee the usual clinical care, particularly to cancer patients, including fertility preservation (FP) strategies before the beginning of the anti-cancer treatments. | 2020-07-14 |
| 32656172 | The most common symptoms were cough in 41 (55.4%) and fever in 38 (51.4%). […] However, 17 (23.0%) children were classified as asymptomatic carriers, with neither symptoms nor radiological findings. […] Although CT is highly sensitive, it should be avoided in follow-up of the disease in consideration of the radiological hazards and limited clinical benefits for mild illness in children. | 2020-07-14 |
| 32656221 | Objectives: Patients with novel coronavirus disease 2019 (COVID-19) can present with gastrointestinal symptoms as their initial symptoms or as the main manifestations during disease progression, but the clinical characteristics of these patients are still unknown. […] 1 People’s Hospital and presented with gastrointestinal symptoms as their initial or main symptoms. […] Their medical records were reviewed by two independent clinical scientists. […] The epidemiological and clinical characteristics as well as the clinical outcomes were analyzed. […] Results: Among 142 confirmed COVID-19 cases, 7 (4.9%) of them presented with gastrointestinal symptoms. […] Three patients had gastrointestinal symptoms as the initial symptoms and chief complaints, and 4 patients as the main symptoms during disease progression. […] Six patients had symptoms of diarrhea (3-16 days), 7 with anorexia (7-22 days), 6 with upper abdominal discomfort (1-7 days), and 4 with nausea (1-7 days), 1 with heartburn lasting 2 days, and 2 with vomiting symptoms (1 day). […] Discussion: COVID-19 patients with gastrointestinal symptoms are relatively rare and might be misdiagnosed. […] The clinical features include watery stools, anorexia, and upper abdominal discomfort. […] The underlying mechanisms of SARS-CoV-2 related gastrointestinal symptoms need to clarify in future studies. | 2020-07-14 |
| 32656222 | We aim to investigate the incidence, characteristics, risk factors, and clinical outcomes of liver injury in patients with COVID-19. […] Demographics, clinical characteristics, treatments, and treatment outcomes between patients with or without liver injury were compared within each group. […] Clinical Trial Registration: World Health Organization International Clinical Trials Registry Platform, ChiCTR2000030593. | 2020-07-14 |
| 32656223 | The baseline, exposure histories, clinical syndromes, laboratory characteristics, nucleic acid, and follow-up tests were analyzed, and the radiological characteristics of re-positive patient at different periods were compared. […] Most patients showed no clinical symptoms and negative nucleic acid tests, while one patient had an itchy throat, her CT scan showed a light density shadow in the right lower lobe of the lung, and the nucleic acid was once again positive. […] Conclusions: The quality of nucleic acid testing reagents should be enhanced, and the training of nucleic acid sampling operators should be strengthened to reduce the false-negative results in the nucleic acid of SARS-CoV-2; the clinical specimens of throat and nasopharynx swabs can be collected at the same time; IgM- and IgG-specific antibodies of SARS-CoV-2 should be carried out for discharged patients; the radiological characteristics should be evaluated strictly; and the discharge standard can be specified according to the baseline and severity of disease of patients. | 2020-07-14 |
| 32656310 | The objectives of this study are to (1) identify the major research themes in COVID-19 literature, (2) determine the origin, symptoms and modes of transmission of COVID, (3) recommend the intervention and mitigation strategies adopted by the Governments globally against the spread of COVID-19 and the traumatization among the public? […] (2) The common symptoms are high fever, dry cough, fatigue, sputum production, shortness of breath, diarrhoea etc. | 2020-07-14 |
| 32656359 | During this pandemic, ophthalmologists around the world adapted their clinical and surgical practice following such guidelines. | 2020-07-14 |
| 32656501 | Significant challenges in operationalizing trials include public policies for managing the pandemic, public health and clinical capacity, travel and migration, and availability of tests and infrastructure. […] We introduce a website to be used by The Bill & Melinda Gates Foundation, Wellcome Trust, and other funders of the COVID Therapeutics Accelerator that accept proposals for future clinical research. […] The portal enables evaluations of clinical study applications that focus on study qualities most likely to lead to informative outcomes and completed studies. | 2020-07-14 |
| 32656565 | PE risk factors in the COVID-19 context do not include traditional thrombo-embolic risk factors but rather independent clinical and biological findings at admission, including a major contribution to inflammation. | 2020-07-14 |
| 32656591 | On univariate analysis, there was no association between blood type and any of the peak inflammatory markers (peak WBC, p = 0.25; peak LDH, p = 0.40; peak ESR, p = 0.16; peak CRP, p = 0.14) nor between blood type and any of the clinical outcomes of severity (admission p = 0.20, ICU admission p = 0.94, intubation p = 0.93, proning while intubated p = 0.58, ECMO p = 0.09, and death p = 0.49). | 2020-07-14 |
| 32656663 | We present a protocol that can be applied in clinical practice: the flowcharts provided, include the modulation of treatment intensity designed for surgical procedures and radiation, stratified for FIGO stage of disease and intention. | 2020-07-14 |
| 32656668 | Obviously, during the first steps of the microevolution of SARS-CoV-2 in the human population, natural selection tends to select viral genomes containing fewer CpG motifs that do not trigger a strong innate immune response, so the infected person has moderate symptoms and spreads SARS-CoV-2 more readily. | 2020-07-14 |
| 32656688 | Primary symptoms and laboratory data of pregnant women with COVID-19 were similar to those of non-pregnant patients. | 2020-07-14 |
| 32656713 | Demographics, comorbidities, and laboratory findings were analyzed according to the olfactory loss or sinonasal symptoms. […] The olfactory impairment and sinonasal symptoms were evaluated by 9 Likert scale questions asked from the patients. […] Thirty-nine (42.39%) patients had notable sinonasal symptoms while rhinorrhea was the first symptom in 3 (3.26%). […] Patients with sinonasal symptoms had a lower age (p = 0.01). […] There was no significant relation between olfactory loss and sinonasal symptoms (p = 0.07). […] Sudden olfactory dysfunction and sinonasal symptoms have a considerable prevalence in patients with COVID-19. […] No significant association was noted between the sinonasal symptoms and the olfactory loss, which may suggest that other mechanisms beyond upper respiratory tract involvement are responsible for the olfactory loss. | 2020-07-14 |
| 32656794 | Therefore, it is paramount that liver practices craft a comprehensive plan for safe resumption of clinical operations while minimizing the risk of exposure to patients and healthcare professionals. | 2020-07-14 |
| 32656888 | Epidemiological, clinical, laboratory, and treatment data were collected and explored the risk factors associated with in-hospital death. | 2020-07-14 |
| 32656939 | The IFN type I is the danger signal for the human body during this clinical setting. […] It is described that several polymorphous cutaneous lesions similar to erythema pernio, urticarial rashes, diffuse or disseminated erythema, livedo racemosa, blue toe syndrome, retiform purpura, vesicles lesions, and purpuric exanthema or exanthema with clinical aspects of symmetrical drug-related intertriginous and flexural exanthema. […] This review describes the complexity of Covid-19, its pathophysiological and clinical aspects. | 2020-07-14 |
| 32657186 | The most frequent symptoms were fever (76%), cough (64%) and dyspnoea (43%). | 2020-07-14 |
| 32657207 | Complex opioid immune modulation may impact host response to COVID-19, though the effect direction and clinical significance are unclear. | 2020-07-14 |
| 32657323 | Significantly increased symptoms were highly prevalent in all dimensions: generalized anxiety (44.9%), depression (14.3%), psychological distress (65.2%) and COVID-19-related fear (59%). | 2020-07-14 |
| 32657340 | The clinical conditions seen in those presenting for care on six small-vessel scientific cruises to Antarctica were analysed. […] Personnel presented with a clinical condition at a rate of 17.9 per 1000 person-days at sea. […] Those providing medical care on such cruises should be prepared to manage a wide range of clinical presentations. | 2020-07-14 |
| 32657343 | Clinical laboratory testing routinely provides actionable results, which help direct patient care in the inpatient and outpatient settings. […] In this context of a novel viral pandemic, clinical laboratories have developed multiple novel assays for SARS-CoV-2 diagnosis and for managing patients afflicted with this illness. | 2020-07-14 |
| 32657436 | An AbM-based mushroom extract (Andosan™), also containing HE and GF, has been shown to significantly reduce bacteraemia and increase survival in mice with pneumococcal sepsis, and to improve symptoms and quality of life in IBD patients via an anti-inflammatory effect. | 2020-07-14 |
| 32657445 | Thus, echocardiography is integral in the timely diagnosis and clinical management of COVID-19 patients. | 2020-07-14 |
| 32657465 | To explore the work experience of clinical first-line nurses treating patients with coronavirus disease 2019 (COVID-19). […] Clinical first-line nurses are at a high risk of infection, and they face a lack of experience and inadequate preparation for COVID-19, leading to physical and psychological disorders. […] Two main categories were defined in the study from the perspective of nurses: negative experiences during clinical first-line work and positive impacts of clinical first-line work. […] Under the first category, two subcategories were included: psychological experiences of clinical first-line work and difficulties faced during clinical first-line work. […] The analysis further yielded two subcategories for the second category: the needs of clinical first-line work and the impact of clinical first-line work on professional attitudes. | 2020-07-14 |
| 32657473 | Through a preliminary analysis of blood indices of COVID-19 patients with a history of hypertension, we found that non-ARB (Angiotensin II receptor blockers) users had more symptoms of severe illness than ARB users. | 2020-07-14 |
| 32657483 | In this review, we aimed to update knowledge about pathogenesis, clinical features and pharmacological treatment of COVID-19 and review the potential beneficial effects of ancient antioxidant, anti-inflammatory and immunomodulatory molecule melatonin for prevention and treatment of COVID-19. | 2020-07-14 |
| 32657527 | To better understand the impact of the coronavirus disease 2019 (COVID-19) pandemic on persons with HIV and improve their care, we present an outpatient and inpatient clinical experience of HIV/SARS-CoV-2 coinfection from Rhode Island, US. […] Twenty-six of the 27 had common COVID-19 symptoms for one to twenty-eight days and most had other co-morbidities and/or risk factors. […] Nine of the 27 were hospitalized for one to thirteen days; of those, three lived in a nursing home, six received remdesivir through a clinical trial or emergency use authorization and tolerated it well; eight recovered and one died. […] The aggregated clinical findings suggest that the clinical presentation and outcomes of COVID-19 appear consistent with those without HIV. | 2020-07-14 |
| 32657540 | Cough, fever, and dyspnea were the most frequent symptoms in all patients. | 2020-07-14 |
| 32657550 | Clinical severity scales, kidney function biomarkers, white blood cell count parameters, the total neutrophils / total lymphocytes ratio and procalcitonin are early risk factors for mortality. | 2020-07-14 |
| 32657601 | Treatment of the infection is still not available; however, antivirals are under clinical trials. | 2020-07-14 |
| 32657602 | The current report investigates the clinical presentations and paraclinical findings of the first confirmed cases and mortalities in the initiation of the outbreak of COVID-19 in Iran. | 2020-07-14 |
| 32657666 | These include organization, time management, proactive and consistent clinical skill development, effective communication, person-centred approaches, self-reflection and self-care. […] This is critical for success during undergraduate medical education and ongoing clinical practice to build personal resilience, provide the best possible clinical care in a different healthcare ecosystem, innovate for better healthcare systems and advocate for more vulnerable communities. […] Our faculty and students have been eager to learn and apply solution-oriented coaching skills to help to mitigate against burnout, hold more rewarding, person-centred conversations in clinical practice and enable them personally to respond flexibly and adapt constructively to change. | 2020-07-14 |
| 32657802 | In spite of intense focus of assessing the performance characteristics of the commercially-available kits, the main issue remains rather invisible, that is, lack of solid science behind COVID-19 serology its clinical usefulness thereof. | 2020-07-14 |
| 32657818 | This case report describes the course and clinical findings of a survivor of acute respiratory distress syndrome due to coronavirus 2019 who was prone positioned while in intensive care and subsequently admitted to an inpatient rehabilitation facility. | 2020-07-14 |
| 32657965 | Although clinical outcomes in the treatment of aspergillosis have markedly improved with the availability of newer triazoles, the development of resistance to these antifungals, especially in Aspergillus fumigatus, is a growing concern. […] The purpose of this review is to provide an update on azole resistance mechanisms and their epidemiology in A. fumigatus, the clinical implications of azole resistance, and to discuss future treatment options against azole-resistant aspergillosis. […] Although current treatment options are limited, newer therapies are in clinical development. […] While treatment options are currently limited, new agents under clinical development may offer hope. | 2020-07-14 |
| 32657967 | Laboratory-developed tests (LDTs) are essential for the clinical care of immunocompromised individuals. […] On March 5th, 2020 the Verifying Accurate and Leading-Edge In-Vitro Clinical Tests Development Act (VALID) was introduced in the US Congress. | 2020-07-14 |
| 32658005 | In both conditions, clinicians may be doubtful regarding the safety of nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, colchicine, and biological agents, such as anti-IL1 agents (e.g. anakinra), that are the mainstay of therapy for pericarditis.For NSAIDs, there is no clear scientific evidence linking ibuprofen and other NSAIDs to worsening of COVID-19; however, it seems prudent to continue them, if necessary to control pericarditis, and on the other hand, to prefer paracetamol for fever and systemic symptoms related to COVID-19. | 2020-07-14 |
| 32658017 | COVID-19 patients who are symptomatic on presentation to the ED and undergo surgical fixation have a 30% inpatient mortality rate compared to 12.5% for patients who are initially asymptomatic but later develop symptoms. […] Patients with COVID-19 symptoms on presentation should have surgery deferred until symptoms improve or resolve and should be reassessed for surgical treatment versus definitive nonoperative treatment with palliative care and/or hospice care. | 2020-07-14 |
| 32658021 | During the COVID-19 pandemic, the care of hip fracture patients remains a clinical priority. […] We collected data on time-to-surgery, Clinical Frailty Scale (CFS) score, Nottingham Hip Fracture Score (NHFS), COVID-19 infection status, 30-day mortality and cause of death. | 2020-07-14 |
| 32658022 | To describe clinical characteristics of fracture patients, including a closer look to hip fracture patients, and determine how epidemiological variables may have influenced on a higher vulnerability to SARS-CoV-2 infection, as the basis for the considerations needed to reintroduce elective surgery during the pandemic. […] Patients were interviewed and charts reviewed for demographic, epidemiological, clinical, and surgical characteristics. […] One was asymptomatic and the other 2 required admission due to COVID-19-related symptoms. | 2020-07-14 |
| 32658054 | After accounting for demographic characteristics, health status, other COVID-19 experiences, and anxiety symptoms, greater job insecurity due to COVID-19 was related to greater depressive symptoms. […] Conversely, after accounting for covariates and depressive symptoms, greater financial concern was related to greater anxiety symptoms. […] Further, greater job insecurity was indirectly related to greater anxiety symptoms due to greater financial concern. | 2020-07-14 |
| 32658096 | This report has important implications for infection control and clinical management of pregnant women with COVID-19 and their newborns. | 2020-07-14 |
| 32658132 | Other recommendations provided by certain societies are related to shelter in place measures, hand hygiene and surface disinfection protocols, patient triage, and thyroid eye disease management. | 2020-07-14 |
| 32658335 | This article provides a review of studies evaluating the role of host (and viral) genetics (including variation in HLA genes) in the immune response to coronaviruses, as well as the clinical outcome of coronavirus-mediated disease. | 2020-07-14 |
| 32658359 | Moreover, we summarize current knowledge about immunologic, clinical, and histologic features of virus- and drug-induced lesions of the skin and changes to the vascular system in order to transfer this knowledge to potential mechanisms induced by SARS-CoV-2. | 2020-07-14 |
| 32658519 | The measure assesses 4 symptom areas, 2 each of internalizing and externalizing symptoms-Depression, Anxiety, Rule-Breaking, and Substance Use-and an optional scale on Isolation at School. […] Also examined was the percentage of youth falling above clinical cutoffs on both the WBI and YSR, and findings demonstrated high concurrent validity. | 2020-07-14 |
| 32658735 | This study provides lead drugs or drug-like molecules for further in vitro and clinical investigation for drug repurposing and new drug development prospects. | 2020-07-14 |
| 32658812 | 22.28% respondents were suffering from depressive symptoms. […] Two additional factors associated with decreased levels of depressive symptoms: hours spend on Internet per day before the epidemic (OR 0.652, 95% CI 0.609-0.697) and tendency to apply problem-focused coping style (OR 0.937, 95% CI 0.923-0.951). | 2020-07-14 |
| 32658813 | Therefore, this study aim to evaluate the prevalence and clinical correlates of depressive symptoms in the general population quarantined during the COVID-19 outbreak in Shenzhen. 2237 quarantined general individuals participated in this cross-sectional study from February 14 to March 4, 2020, during their 14 days quarantine. […] They completed the Zung’s Self-Rating Depression Scale (SDS) for depression, Zung’s self-rating anxiety scale (SAS) for anxiety, the Pittsburgh Sleep Quality Index (PSQI) for sleep quality, and the Impact of Events Scale-Revised (IES-R) for post-traumatic stress symptoms (PTSS). […] The depressed group were younger, less married and educated, and had higher SAS, PSQI, IES-R total scores (all p<0.05), as well as more avoidance, intrusion and hyperarousal symptoms than the non-depressed group. […] Some demographic and clinical variables were associated with depressive symptoms. | 2020-07-14 |
| 32658818 | This study explored the prevalence of depressive symptoms (depression hereafter) and its relationship with quality of life (QOL) in clinically stable patients with COVID-19. | 2020-07-14 |
| 32658823 | Mental health outcomes: 62.5% HCW exposed to SARS/MERS/COVID-19 reported general health concerns (95%CI=57.0-67,8%, k=2, n=2254), 43.7% fear (95%CI=33.9-54.0%, k=4, n=584), 37.9% insomnia (95%CI=30.9-45.5%, k=6, n=5067), 37.8% psychological distress (95%CI=28.4-48.2%, k=15, n=24,346), 34.4% burnout (95%CI=19.3-53.5%, k=3, n=1337), 29.0% anxiety features (95%CI=14.2-50.3%, k=6, n=9191), 26.3% depressive symptoms (95%CI=12.5-47.1%, k=8, n=9893), 20.7% post-traumatic stress disorder features (95%CI=13.2-31%, k=11, n=3826), 16.1% somatisation (95%CI=0.2-96.0%, k=2, n=2184), 14.0% stigmatisation feelings (95%CI=6.4-28.1%, k=2, n=411). | 2020-07-14 |
| 32658829 | The COVID-19 pandemic and lockdown might increase anxiety and depressive symptoms, but some behaviors may protect against them. […] To provide a preliminary evidence of the behaviors associated with decreased symptoms in the current COVID-19 pandemic and lockdown, we conducted a survey of 5545 adult individuals from the Spanish general population, two weeks after an official lockdown was established across the country. […] Sixty-five percent of the sample reported anxiety or depressive symptoms. […] Following a healthy/balanced diet and not reading news/updates about COVID-19 very often were the best predictors of lower levels of anxiety symptoms. […] Following a healthy/balanced diet, following a routine, not reading news/updates about COVID-19 very often, taking the opportunity to pursue hobbies, and staying outdoors or looking outside were the best predictors of lower levels of depressive symptoms. […] This study suggests that “simple” coping behaviors may protect against anxiety and depressive symptoms during the COVID-19 pandemic and lockdown. | 2020-07-14 |
| 32658837 | Only one patient developed a mild aggravation of asthma symptoms associated with SARS-CoV-2 infection. | 2020-07-14 |
| 32658841 | This result may allow us to test the safety and efficacy of this product in a phase 2/3 clinical trial to be conducted in July 2020 in the metropolitan area of Buenos Aires, Argentina. | 2020-07-14 |
| 32658844 | This is an analysis of clinical characteristics, images findings, laboratory variables and respiratory mechanics in patients with coronavirus disease 2019 (COVID-19) during the first month of the pandemic outbreak in Buenos Aires. […] Patients most common clinical manifestations were fever (7), cough (5), asthenia (4) and shortness of breath (3). | 2020-07-14 |
| 32658848 | The available information indicates that approximately 80% of people with COVID-19 will develop mild symptoms and will not require hospital care, while 15% will require intermediate or general room care, and the remaining 5% will require assistance in intensive care units. | 2020-07-14 |
| 32658857 | We summarized the data we extracted as answers to specific clinical questions. […] We produced a comprehensive synthesis of guidance answering a wide range of clinical questions in telepsychiatry. | 2020-07-14 |
| 32658876 | Several tools have been developed and launched at national and international level to face the emergency, including tools to perform online triage, symptoms checking, video visits and remote monitoring, and to conduct local and national epidemiological surveillance studies. […] In order to decide whether to continue using these tools even after the pandemic is over, it could be useful to perform validation and efficacy studies of these tools to study their implications on the doctor-patient relationship, to understand if the new features can be integrated with the other technological tools already in use, and if they can improve clinical practice and quality of care. | 2020-07-14 |
| 32658878 | For this reason, new skills and organizational methods are needed to create a care approach capable of integrating technology opportunities with the traditional clinical method. | 2020-07-14 |
| 32658880 | The psychological impact of CoViD-19 disease must be recognized alongside the physical symptoms for all those affected. | 2020-07-14 |
| 32658884 | The patients were managed from remote until the symptoms were over. […] The results are discussed in relationship to the procedures put in practice, to the perspectives in the use of clinical televideoconsultation in the Italian health system, mainly in support to the primary health care, and to the limitations due to the poor development of other e-health tools such as the citizen’s electronic health record. | 2020-07-14 |
| 32659100 | Variability in diagnostic accuracy was reported, but appears improved given proper clinical context. | 2020-07-14 |
| 32659175 | Previous reports have linked 25-hydroxy vitamin D deficiency with subclinical interstitial lung disease. […] We propose that randomized clinical trials are needed to examine the potential of co-supplementation with anti-inflammatory antioxidants, vitamin D and L-cysteine in correcting the 25(OH)VD deficiency and preventing the ‘cytokine storm,’ one of the most severe consequences of infection with COVID-19, thereby preventing the adverse clinical effects of COVID-19 infection in the vulnerable AA population. | 2020-07-14 |
| 32659199 | At present, the physiopathologic mechanisms accounting for the onset of these symptoms are not yet clarified. | 2020-07-14 |
| 32659214 | Demographic, clinical, laboratory, treatment, and outcome data were extracted from electronic medical records and compared between patients with moderate, severe, and critical disease (defined according to the diagnosis and treatment protocol for novel coronavirus pneumonia, trial version 7, published by the National Health Commission of China). | 2020-07-14 |
| 32659224 | The initial clinical features of SARS-CoV-2 infection are quite nonspecific and not all suspected patients can be tested to exclude or confirm the diagnosis. […] Increasing scientific evidence has shown that abnormalities in routine laboratory tests, particularly hematological tests, have the potential to indicate, in a quick, practical and economical way, the need for specific laboratory tests for the diagnosis of SARS-CoV-2 infection, besides assisting in the prognosis of the disease and in the optimization of its clinical monitoring. | 2020-07-14 |
| 32659240 | The clinical and epidemiologic management of the SARS-CoV-2 pandemic is critically dependent on molecular assays with short turn-around time. | 2020-07-14 |
| 32659267 | As a healthy practice, calorie restriction in the form of intermittent fasting (IF) in several clinical settings has been reported to promote several health benefits, including priming of the immune response. | 2020-07-14 |
| 32659293 | While preliminary choices were essentially based on in vitro potency, clinical translation into effective therapies may be challenging due to unfavorable in vivo pharmacokinetic properties at the doses chosen for this new indication of COVID-19 infection. […] A special attention should be paid to pre-analytical and analytical requirements and to the proper collection of covariates affecting dose-exposure relationships (co-medications, use of specific organ support techniques and other clinical and para-clinical data). […] We also promote the development of population PK and PK-PD models specifically dedicated to COVID-19 patients since those previously developed for other diseases (SEL, malaria, HIV) and clinical situations (steady-state, non-ICU patients) are not representative of severe patients. […] For that purpose we call for multi-institutional collaborative work and involvement of clinical pharmacologists in multidisciplinary research consortia. | 2020-07-14 |
| 32659342 | We present a review of the indications and protocols for focused HH-POCUS use in an acute setting and formulate proposals for streamlining their application in the COVID-19 context towards guiding optimum management of these patients while at the same time allowing adherence to robust infection control measures to provide safety to both the patient and our clinical staff. | 2020-07-14 |
| 32659363 | Best practices of data monitoring committees (DMCs) in randomized clinical trials are well established. […] Because numerous clinical trials are being concurrently conducted in the COVID-19 setting, often addressing closely related scientific questions, structures for DMC oversight should be efficient and adequately informative. […] When these concurrently conducted trials are evaluating related regimens in related clinical settings, often individually underpowered for safety and having separate DMCs, processes should be implemented enabling these DMCs to share with each other emerging confidential evidence to better assess risks and benefits. […] Ideally a single DMC would monitor a portfolio of clinical trials or a trial with multiple arms, such as a platform trial. | 2020-07-14 |
| 32659414 | All relevant articles providing information on PCR tested COVID-19 positive patient population with clinical characteristics and epidemiological information were selected for review and analysis. | 2020-07-14 |
| 32659475 | Epidemiological and clinical data were collected prospectively for patients attending the Royal Marsden Hospital and three network hospitals between March 1st and April 30th 2020 that were confirmed to have Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection. […] Significance of clinical and pathological characteristics was assessed using the Fisher’s exact test and Wilcoxon rank sum test, whilst univariate and multivariate logistic regression models were used to further assess risk. | 2020-07-14 |
| 32659612 | To assess trends of Google Search queries for symptoms and complaints encountered commonly in otolaryngology practices during the coronavirus disease 2019 (COVID-19) pandemic when in-person care has been limited. | 2020-07-14 |
| 32659620 | Fifty-eight cytologic preps (20 oral and 38 from the nasopharynx) were obtained from ten patients and analyzed in a blinded fashion for SARS-CoV-2 spike and envelope protein by immunohistochemistry and viral RNA by in situ hybridization. qRTPCR identified three positive cases and seven controls; the three cases reported mild symptoms that resolved in 2-3 days. | 2020-07-14 |
| 32659710 | Careful validation is encouraged before clinical laboratories start using these tests. | 2020-07-14 |
| 32659713 | This study evaluates the capacity of the Aptima™ Transcription-Mediated Amplification (TMA) assay (Hologic® Panther System) to detect the virus in clinical samples. | 2020-07-14 |
| 32659729 | Interstitial pneumonia appears to be the most common clinical manifestation of coronavirus infection. | 2020-07-14 |
| 32659783 | At present, there are no known clinical findings, immunological assays or biomarkers that can differentiate any severe viral infection from immune-enhanced disease, whether by measuring antibodies, T cells or intrinsic host responses. […] First, comprehensive studies are urgently needed to define clinical correlates of protective immunity against SARS-CoV-2. | 2020-07-14 |
| 32660185 | Presently, there are no specific drugs for COVID-19; however, a variety of potentially effective antiviral drugs, vaccines, cell therapies, traditional Chinese medicine and other methods are in clinical trials. […] The pathogenesis of COVID-19 combined with liver injury in existing studies is still unclear, and relevant guidelines and expert consensuses are insufficient for clinical diagnosis and treatment. | 2020-07-15 |
| 32660186 | This could be one of the reasons for the diversity of clinical manifestations of COVID-19, or it may be the cause of accelerated disease progression and multi-system damage. […] This article reviews the clinical manifestations of COVID-19 related to the extrapulmonary system such as digestive, circulatory, urogenital, hematopoietic and nervous. | 2020-07-15 |
| 32660240 | A total of 28 clinical positive and 77 negative serum or plasma samples were included in the test. | 2020-07-15 |
| 32660281 | Of tested positive women, 22 (44.9%) had symptoms or reported close contacts with positive patients, that is were found at risk by the itemized questionnaire. | 2020-07-15 |
| 32660314 | Twenty-nine clinical trials were deemed eligible, 21 RCTs and 8 nonrandomized studies, while 11 RCTs contributed to the network meta-analysis, comprising 10 competing interventions. | 2020-07-15 |
| 32660335 | Objectives: Emory University has modified its clinical practices across specialties in response to the 2020 COVID-19 pandemic to provide service delivery while maintaining patient, staff, and faculty safety. […] Nevertheless, development of robust teleNP protocols should expand availability of neuropsychology in both clinical and research applications while simultaneously decreasing assessment burden associated with traveling - sometimes long distances - for diagnostic neuropsychological evaluation. | 2020-07-15 |
| 32660339 | Intranasal drug delivery has potential relevance for future clinical trials in the settings of disease spread prevention and treatment of SARS-CoV-2 and other viral diseases. | 2020-07-15 |
| 32660352 | Moreover, the chronic stress of living through a pandemic led to a host of physical symptoms, like headaches, insomnia, digestive problems, hormonal imbalances, and fatigue. | 2020-07-15 |
| 32660401 | Moreover, numerous studies and clinical trials are being carried out in order to determine the efficacy of current pharmaceutical and natural products to establish possible therapeutic strategies for producing novel COVID-19 medicines. | 2020-07-15 |
| 32660568 | The CoV-SCR web-app (http://bit.ly/covscrapp) enables individuals to keep a personal record of their close contacts and monitor their symptoms on a daily basis, so that they can provide relevant and accurate details when they see the doctor and during the contact tracing process. […] Individuals can record their temperature and rate their symptoms on a 5-point severity scale, as well as record details of their travel and contact history for the last 14 days. | 2020-07-15 |
| 32660611 | PK/PD/Immunogenicity • Change in serum ravulizumab concentrations over time • Change in serum free and total C5 concentrations over time • Incidence and titer of anti-ALXN1210 antibodies Biomarkers • Change in absolute level of soluble biomarkers in blood associated with complement activation, inflammatory processes, and hypercoagulable states over time Exploratory • Incidence of progression to renal failure requiring dialysis at Day 29 • Time to clinical improvement (based on a modified 6-point ordinal scale) over 29 days • SF-12 Physical Component Summary (PCS) and Mental Component Summary (MCS) scores at Day 29 (or discharge), Day 60, and Day 90 • EuroQol 5-dimension 5-level (EQ-5D-5L) scores at Day 29 (or discharge), Day 60, and Day 90 TRIAL DESIGN: This is a multicenter Phase 3, open-label, randomized, controlled, study. […] Key Inclusion criteria • Confirmed diagnosis of SARS-CoV-2 infection (eg, via polymerase chain reaction [PCR] and/or antibody test) presenting as severe COVID-19 requiring hospitalization • Severe pneumonia, acute lung injury, or ARDS confirmed by computed tomography (CT) or X-ray at Screening or within the 3 days prior to Screening, as part of the patient’s routine clinical care • Respiratory distress requiring mechanical ventilation, which can be either invasive (requiring endotracheal intubation) or non-invasive (with continuous positive airway pressure [CPAP] or bilevel positive airway pressure [BiPAP]) Key Exclusion criteria • Patient is not expected to survive for more than 24 hours • Patient is on invasive mechanical ventilation with intubation for more than 48 hours prior to Screening • Severe pre-existing cardiac disease (ie, NYHA Class 3 or Class 4, acute coronary syndrome, or persistent ventricular tachyarrhythmias) • Patient has an unresolved Neisseria meningitidis infection Excluded medications and therapies • Current treatment with a complement inhibitor • Intravenous immunoglobulin (IVIg) within 4 weeks prior to randomization on Day 1 Excluded prior/concurrent clinical study experience • Treatment with investigational therapy in a clinical study within 30 days before randomization, or within 5 half-lives of that investigational therapy, whichever is greater • Exceptions a. […] Investigational antiviral therapies (such as remdesivir) will be allowed even if received as part of a clinical study. […] There is no active or placebo comparator in this open-label clinical trial. […] Clinicaltrials.gov: Protocol Registry Number: NCT04369469 ; First posted; 30 Apr 2020 EU Clinical Trials Register: EudraCT Number: https://www.clinicaltrialsregister.eu/ctr-search/search? | 2020-07-15 |
| 32660623 | There is a need for validated clinical risk scores to identify patients at risk of severe disease and to guide decision-making during the covid-19 pandemic. […] We aimed to study the performance of NEWS2 and compare commonly used clinical risk stratification tools at admission to predict risk of severe disease and in-hospital mortality in patients with covid-19. […] The main outcome was the ability of the NEWS2 score and other clinical risk scores at emergency department admission to predict severe disease and in-hospital mortality in covid-19 patients. […] Areas under the curve (AUCs) for the clinical risk scores were compared using DeLong’s test. […] NEWS2 was superior to qSOFA score ≥ 2 (AUC 0.624, 95% CI 0.446-0.810, p < 0.05) and other clinical risk scores for this purpose. […] NEWS2 score at hospital admission predicted severe disease and in-hospital mortality, and was superior to other widely used clinical risk scores in patients with covid-19. | 2020-07-15 |
| 32660660 | In 2015, updated guidelines were released to ensure that: (1) revisions reflect the public’s values and (2) the triage protocol is substantiated by evidence-based clinical data. […] We summarize the development and content of the 2015 Guidelines compared with the 2007 version, emphasizing new/revised aspects of the ethical considerations and clinical protocol. […] We compared the 2007 and 2015 guidelines, with particular emphasis on the ethical issues and clinical protocols. […] The 2015 Guidelines retained much of the ethical and clinical framework of the 2007 draft. […] The triage protocol was revised using evidence-based clinical data. […] Protocol consists of exclusion criteria, the sequential organ failure assessment (SOFA) score, and periodic clinical assessments. | 2020-07-15 |
| 32660662 | However, as this was impossible for Obstetrics, the COVID-19 infection had to be added to existing clinical care pathways at the children’s hospital, Hôpital Necker-Enfants Malades. […] Weekly medical manager team meetings covered the evolving clinical situation, and an initial evaluation revealed that our procedures worked well. | 2020-07-15 |
| 32660687 | The study also revealed that some participants (11.2%), due to a lower education, did not visit a medical clinic when they experienced possible symptoms of SARS-CoV-2 infection. | 2020-07-15 |
| 32660697 | One study reported that 19% of males with COVID-19 infection had scrotal symptoms suggestive of viral orchitis which could not be confirmed. […] It has been reported an increase in serum levels of LH in males with COVID-19 and a significant reduction in the T/LH and FSH/LH ratios, consistent with subclinical hypogonadism. | 2020-07-15 |
| 32660776 | Lockdown-related noteworthy events consisted in clinical cases or other relevant information for which lockdown clearly played an important role: among the many substances identified at least once, pregabalin, benzodiazepines, cannabis, cocaine and nitrous oxide were the most significant in terms of prevalence, seriousness or particularly specific to the lockdown context. | 2020-07-15 |
| 32660876 | We developed recurring peer support groups via videoconferencing and telephone for physicians, resident physicians, and nursing staff, focusing on issues and emotions related to their frontline clinical work with COVID patients in our medical center which was designated as a COVID-only hospital by the state. […] Our experience suggests that this method of offering telehealth peer support groups and individual counseling is a useful model for other centers to adapt to emotionally support frontline clinical workers in this ongoing worldwide crisis. | 2020-07-15 |
| 32660890 | COVID-19 has a clear sex disparity in clinical outcome. | 2020-07-15 |
| 32660907 | Only 30%, 40% and 53% of participants were aware of modes of transmission (respiratory droplets and fomites), cardinal symptoms (fever, cough and breathing difficulty) and means of prevention (staying indoors, social distancing and regular hand washing), respectively. | 2020-07-15 |
| 32660964 | Patients with cirrhosis+COVID-19 versus patients with COVID-19 alone had equivalent respiratory symptoms, chest findings and rates of intensive care unit transfer and ventilation. […] However, patients with cirrhosis+COVID-19 had worse Charlson Comorbidity Index (CCI 6.5±3.1 vs 3.3±2.5, p<0.001), lower presenting GI symptoms and higher lactate. | 2020-07-15 |
| 32660970 | We evaluated biopsied kidney samples from ten patients at our institution who had COVID-19 and clinical features of AKI, including proteinuria with or without hematuria. […] We documented clinical features, pathologic findings, and outcomes. | 2020-07-15 |
| 32661006 | In this randomized clinical trial, the efficacy and safety of IFN β-1a were evaluated in patients with severe COVID-19. […] The primary outcome of the study was time to reach clinical response. […] As the primary outcome, time to the clinical response was not significantly different between the IFN and the control groups (9.7 ± 5.8 versus 8.3 ± 4.9 days, respectively, P = 0.95). […] Although IFN did not change the time to reach the clinical response, adding it to the national protocol significantly increased discharge rate on day 14 and decreased 28-day mortality. […] (This study is in the Iranian Registry of Clinical Trials under identifier IRCT20100228003449N28.). | 2020-07-15 |
| 32661009 | The authors reported the proportion of consultation type across five categories: clinical administration, electronic/video, face-to-face, telephone, and home visits. | 2020-07-15 |
| 32661235 | As SPs also attract a great interest as potential antiviral targets (e.g., COVID-19), we also discuss the present progress and challenges in this area of HSP-based drug development, as well as with compounds already under clinical evaluation. | 2020-07-15 |
| 32661375 | Therefore, the clinical and scientific communities have joint efforts to reduce the severe impact of the outbreak. | 2020-07-15 |
| 32661497 | Currently, a majority of clinical trials are evaluating therapies in patients who are already hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) infection. […] Given that the median time between development of symptoms and need for hospitalization is 1 week, a golden opportunity to intervene early is being missed. […] Indeed, for many other viral infections, early treatment soon after development of symptoms is associated with decreased mortality, lower hospitalization rates, and lower likelihood of transmission to others. […] In this study, we advocate for randomized, double-blind, placebo controlled, clinical trials to evaluate promising agents early during SARS CoV-2 infection. | 2020-07-15 |
| 32661499 | The most common symptoms of COVID-19 patients in this study were cough (82%), fever (64%), and chest distress (42%). | 2020-07-15 |
| 32661507 | Due to the combination of underlying diseases, elderly patients may exhibit atypical manifestations in clinical symptoms, supplementary examinations, and pulmonary imaging, deserving particular attention. | 2020-07-15 |
| 32661585 | Up to 20% of northern participants were redeployed to clinical services. | 2020-07-15 |
| 32661757 | We performed a systematic review to characterize the clinical characteristics, neuroimaging findings, and outcomes of AIS in COVID-19 patients. […] The mean duration of AIS from COVID-19 symptoms onset was 10 ± 8 days, and the mean NIHSS score was 19 ± 8. | 2020-07-15 |
| 32661758 | System processes timings, treatment and clinical outcome variables were collected. | 2020-07-15 |
| 32661780 | The Italian College of Breast Radiologists by the Italian Society of Medical Radiology (SIRM) provides recommendations for breast care provision and procedural prioritization during COVID-19 pandemic, being aware that medical decisions must be currently taken balancing patient’s individual and community safety: (1) patients having a scheduled or to-be-scheduled appointment for in-depth diagnostic breast imaging or needle biopsy should confirm the appointment or obtain a new one; (2) patients who have suspicious symptoms of breast cancer (in particular: new onset palpable nodule; skin or nipple retraction; orange peel skin; unilateral secretion from the nipple) should request non-deferrable tests at radiology services; (3) asymptomatic women performing annual mammographic follow-up after breast cancer treatment should preferably schedule the appointment within 1 year and 3 months from the previous check, compatibly with the local organizational conditions; (4) asymptomatic women who have not responded to the invitation for screening mammography after the onset of the pandemic or have been informed of the suspension of the screening activity should schedule the check preferably within 3 months from the date of the not performed check, compatibly with local organizational conditions. | 2020-07-15 |
| 32661794 | As the current understanding of COVID-19 continues to evolve, a synthesis of the literature on the neurological impact of this novel virus may help inform clinical management and highlight potentially important avenues of investigation. […] In this review, we synthesize a range of clinical observations and initial case series describing potential neurologic manifestations of COVID-19 and place these observations in the context of coronavirus neuro-pathophysiology as it may relate to SARS-CoV-2 infection. | 2020-07-15 |
| 32661796 | Despite several studies, there is yet a dearth of data regarding the mechanisms of cardiac injury, clinical presentation, risk factors, and treatment of COVID-19-associated cardiovascular disease. […] This systematic review and meta-analysis is aimed at defining the clinical, electrocardiographic, and pathologic spectrum of cardiovascular disease (CVD), frequency of elevated cardiac and inflammatory biomarkers, and their frequency and relationship with severity of the disease and mortality in COVID-19 patients and to develop a triage risk stratification tool (TRST) that can serve as a guide for the timely recognition of the high-risk patients and mechanism-targeted therapy. | 2020-07-15 |
| 32661859 | The symptoms vary from person to person and many are “hidden carriers.” […] However, many show mild to chronic symptoms and recover. […] Clinical evidence has suggested the risk of getting infected is high among individuals with non-communicable diseases such as cardiovascular disease, type-2 diabetes, cancer, acute respiratory distress syndrome, and renal disease, as well as the elderly with high mortality rate among the cohort. […] Future research and clinical trials can apply the suggestions given in this article to support metabolic activities in patients and enhance the immune response. | 2020-07-15 |
| 32661867 | However, MSCs, despite being used in various other clinical trials have always been questioned for their tendency to aggregate or form clumps in the injured or disease microenvironment. | 2020-07-15 |
| 32661928 | We prepared a web-based survey investigating the clinical findings and contact histories among pediatric patients with AIDs. […] Confirmed COVID-19 cases, patients with contact history and those with symptoms which were highly suggestive of COVID-19 were called via phone or recruited to a video or face to face appointment. | 2020-07-15 |
| 32661930 | We describe a scaled approach to managing hospitalist clinical operations during the COVID-19 pandemic. | 2020-07-15 |
| 32661947 | Endothelial dysfunction, subclinical hypogonadism, psychological distress and impaired pulmonary hemodynamics all contribute to the potential onset of ED. | 2020-07-15 |
| 32662041 | To compare and analyze the clinical and CT features of coronavirus disease 2019 (COVID-19) among four different age groups. 97 patients (45 males, 52 females, mean age, 66.2 ± 5.0) with chest CT examination and positive reverse transcriptase-polymerase chain reaction test (RT-PCR) from January 17, 2020 to February 21, 2020 were retrospectively studied. […] The patients were divided into four age groups (children [0-17 years], young adults [18-44 years], middle age [45-59 years], and senior [≥ 60 years]) according to their age after the diagnosis was made based on PCR test and clinical symptoms. […] Older patients were found to have a higher incidence of the highest clinical classification (severe or critical) in these four groups. […] The clinical and imaging features of patients in different age groups were found to be significantly different. […] A better understanding of the age differences in comorbidities, cluster onset, highest clinical classification, large/multiple GGO, numbers of lobes affected, and frequency of lobe involvement can be useful in the diagnosis of COVID-19 patients of different ages. | 2020-07-15 |
| 32662058 | Based on different categories of disease severity (asymptomatic, regional/systemic symptoms, hospitalisation, myocardial damage, and/or myocarditis), in this point-of-view article we offer the (sports) cardiologist or sports physician in the Netherlands a practical guide to pre-participation screening, and diagnostic and management strategies in all athletes >16 years of age after COVID-19 infection. | 2020-07-15 |
| 32662060 | We present the case of an oncology patient admitted to our hospital during the current COVID-19 pandemic with clinical and radiological features strongly suggestive of interstitial pneumonia. […] The importance of differential diagnostics in clinical practice should be a given, especially during times of pandemic. | 2020-07-15 |
| 32662062 | We have studied up-to-date knowledge about the clinical feature of the Novel coronavirus pandemic worth consideration by the urologist. […] Symptoms and signs, clinical features, and laboratory findings of the renal transplant patients are almost similar to non-transplanted patients. | 2020-07-15 |
| 32662099 | As much as the researchers are inundated for the quest of effective treatments from available drugs, the discovery and trials of new experimental drugs are also at a threshold for clinical trials. | 2020-07-15 |
| 32662129 | Posttraumatic stress symptoms related to the COVID-19 pandemic are common in the general population. […] Our results show that health professionals responsible for responding to the COVID-19 pandemic should expect to routinely encounter symptoms and concerns related to posttraumatic stress. | 2020-07-15 |
| 32662203 | The remdesivir could be considered the closest bifunctional drug to the provisional clinical administration for SARS-CoV-2. | 2020-07-15 |
| 32662303 | A cross-sectional survey was conducted with 622 youth participants across existing clinical and community cohorts. […] Reports of prepandemic mental health compared to intrapandemic mental health show a statistically significant deterioration of mental health across clinical and community samples (P < 0.001), with greater deterioration in the community sample. […] A total of 68.4% of youth in the clinical sample and 39.9% in the community sample met screening criteria for an internalizing disorder. […] Substance use declined in both clinical and community samples (P < 0.001), although 23.2% of youth in the clinical sample and 3.0% in the community sample met screening criteria for a substance use disorder. | 2020-07-15 |
| 32662314 | Obstetricians have had to adapt quickly to these changes without knowing how they affected their clinical practice. […] For each woman with confirmed or suspected SARS-CoV-2 infection, a woman who had a cesarean section for the same indication during the COVID-19 pandemic and with similar clinical history but not affected by SARS-CoV-2 was included. 42 cesarean sections were studied. | 2020-07-15 |
| 32662342 | As soon as the causative pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified and its genome sequence determined, a laboratory diagnosis based on nucleic acid amplification technologies was quickly established and has played essential roles in the confirmation of a clinical diagnosis. […] Nevertheless, with overwhelming numbers of patients and potentially large numbers of asymptomatic cases, clinical laboratories encounter enormous challenges in diagnostic approaches that can rapidly and accurately identify infected persons. | 2020-07-15 |
| 32662396 | In this report, the course over time of rRT-PCR for SARS-CoV-2 in 26 clinical specimens collected from the upper (nasopharyngeal and throat swabs) and lower (sputum) respiratory tracts of COVID-19 cases with pneumonia was investigated along with the clinical course. | 2020-07-15 |
| 32662525 | Electronic medical records, including patient demographics, clinical manifestation, comorbidities, laboratory tests results, and radiological materials, were collected and analyzed. […] Clinical, laboratory, and radiological data were compared among these groups. […] Correlations between clinical, radiological, and laboratory parameters were investigated. […] Survived severe and nonsurvived COVID-19 patients had distinct clinical and laboratory characteristics, which were separated by principle component analysis. […] Longitudinal changes of laboratory findings may be helpful in predicting disease progression and clinical outcome of severe patients. | 2020-07-15 |
| 32662571 | In this article, clinical perspectives are shared to clearly define emerging healthcare needs that can be met by biomaterials solutions. | 2020-07-15 |
| 32662615 | Methods We performed a retrospective analysis of a prospective institutional database, which included the operation types, paraclinical investigations and postoperative complications of all patients undergoing emergency general surgery operations between March - May 2020. | 2020-07-15 |
| 32662677 | The combination of both approaches shall revolutionize healthcare, accelerating clinical trial processes and reducing the costs and time involved in drug research and development. […] The topics include a detailed description of epitope prediction tools for designing epitope-based vaccines and agent-based models for immune system response prediction, along with a focus on their potentiality to facilitate clinical trial phases. | 2020-07-15 |
| 32662686 | Furthermore, it is now being reported that a number of children appear to be reacting to the new coronavirus by developing a multisystem hyperinflammatory state with similar symptoms to that seen in toxic shock syndrome and which necessitates intensive care (Campbell & Sample, 2020). | 2020-07-15 |
| 32662690 | We sequentially identified a series of patients who were requiring at least 30% of FiO2 or more who received IV vitamin C as part of the COVID-19 treatment and analyzed their demographic and clinical characteristics. | 2020-07-15 |
| 32662692 | Prevalence of depression and anxiety symptoms were diagnosed in 35.9% and 38.5% of the patients, respectively. | 2020-07-15 |
| 32662717 | The novel coronavirus has distinct clinical stages related to the immune response. | 2020-07-15 |
| 32662735 | Further studies are necessary to determine clinical applicability. | 2020-07-15 |
| 32662745 | Differences between inpatients and outpatients are potentially reflective of timeline of olfactory symptoms and contextual factors, underscoring the importance of corroborative objective testing, coupled with careful tracking of temporal relationships. | 2020-07-15 |
| 32662757 | We reached a consensus on a core data set and established data sharing processes with multiple partners to address an urgent need for information to guide clinical practice. | 2020-07-15 |
| 32662814 | Although COVID-19 can be rapidly diagnosed, efficient clinical treatment of COVID-19 remains unavailable, resulting in high fatality. […] Some clinical trials have identified vitamin C (VC) as a potent compound pneumonia management. | 2020-07-15 |
| 32662867 | The study indicates that surveillance of wastewater from large transport vessels with their own sanitation systems has potential as a complementary data source to prioritize clinical testing and contact tracing among disembarking passengers. […] The potential for false negatives by both wastewater testing and clinical swab testing suggests that the two strategies could be employed together to maximize the probability of detecting SARS-CoV-2 infections amongst passengers. | 2020-07-15 |
| 32662869 | Furthermore, outcomes 30 days after onset of symptoms and after hospital discharge have not been described. […] To describe the clinical characteristics, outcomes 30 days after onset of symptoms and in-hospital mortality of a cohort of patients hospitalised for COVID-19 in a Swiss area. […] Rate of potential hospital-acquired infection, outcomes 30 days after onset of symptoms and in-hospital mortality are reported. […] Overall, 30 days after onset of symptoms 117 patients (60%) had returned home, 23 patients (12%) were in a rehabilitation facility, 18 patients (9%) in a medical ward, 6 patients (3%) in ICU and 32 (16%) patients had died. […] Among patients who returned home within 30 days, 73 patients (63%) reported persistent symptoms. […] Thirty days after onset of the symptoms, 60% had returned home. […] Among them, 63% still presented symptoms. | 2020-07-15 |
| 32662893 | Demographic, clinical data, and routine blood parameters were analyzed. | 2020-07-15 |
| 32662899 | We report a case series of five patients affected by SARS-CoV-2 who developed neurological symptoms, mainly expressing as polyradiculoneuritis and cranial polyneuritis in the 2 months of COVID-19 pandemic in a city in the northeast of Italy. […] A diagnosis of Guillain-Barré syndrome was made on the basis of clinical presentation, cerebrospinal fluid analysis, and electroneurography. […] In four of them, the therapeutic approach included the administration of intravenous immunoglobulin (0.4 g/kg for 5 days), which resulted in the improvement of neurological symptoms. […] Clinical neurophysiology revealed the presence of conduction block, absence of F waves, and in two cases a significant decrease in amplitude of compound motor action potential compound muscle action potential (cMAP). | 2020-07-15 |
| 32663041 | The proportion of persons infected with SARS-CoV-2 whose infection remained subclinical is not known. | 2020-07-15 |
| 32663071 | The daily case rate is now declining in many states and there is a need for guidance about the resumption of elective clinical services for patients with lung disease or sleep conditions. […] The community new case rate should be consistently low or have a downward trajectory for at least 14 days before resuming elective clinical services. | 2020-07-15 |
| 32663073 | Clinically, the outbreaks lasted for about 4 weeks but some animals were still polymerase chain reaction-positive for SARS-CoV-2 in throat swabs after clinical signs had disappeared. […] This is the first report of the clinical and pathological characteristics of SARS-CoV-2 outbreaks in mink farms. | 2020-07-15 |
| 32663315 | We compare and contrast the learnings of flexibility of time, space, procedures, or attendance we acquired in this clinical community setting during regular times, with the new challenges families and therapists face, and the adaptations needed to continue to work with our clients in culturally responsive and empowering ways during the COVID-19 pandemic. | 2020-07-15 |
| 32663338 | With the emergence of the COVID-19 pandemic in Canada and the curtailment of clinical and face-to-face university instruction in British Columbia on March 16, 2020, the opportunity arose to explore how third- and fourth-year undergraduate dental students critically considered the impact of the pandemic on education and the practice of dental geriatrics. | 2020-07-15 |
| 32663348 | Here, we provide an overview of these (pre)clinical efforts and provide background information on the technologies behind these vaccines. […] In addition, we discuss potential hurdles that need to be addressed prior to mass scale clinical translation of successful vaccine candidates. | 2020-07-15 |
| 32663351 | Only 27% were aware of feco-oral transmission, and 34% knew about gastrointestinal symptoms of COVID-19. 100% of parents understood concept of social distancing, and 70% knew that asymptomatic individuals can transmit the virus. […] Television followed by newspapers was the main source of their information, though over 40% claim to regularly receive information through social media. 87% would consult their doctor if the child had flu-like symptoms rather than modify immunosuppression or try alternative medications. […] Parental concerns mainly revolved around early recognition of symptoms, queries on unconventional treatments circulating over social media, and supply of medications during the lockdown period. | 2020-07-15 |
| 32663356 | This comprehensive review summarises the latest evidence from published studies and discusses the implications of the various haematological manifestations of COVID-19 with a view to guiding clinical management and risk stratification in this rapidly evolving pandemic. | 2020-07-15 |
| 32663364 | We are overwhelmed by scientific publications on clinical observations, virology and epidemiology of SARS-CoV-2 infections. | 2020-07-15 |
| 32663490 | Despite this, he displayed no obvious clinical symptoms and improved chest CT. | 2020-07-15 |
| 32663494 | Retrospective descriptive study of cases that met COVID-19 clinical diagnosis criteria or had a positive PCR test from February 27 to June 29, 2020. | 2020-07-15 |
| 32663575 | In this review, we have critically compared the clinical impact of several potential therapeutic agents that could block or interfere with the cytokine storm, such as IL-1 inhibitors, IL-6 inhibitors, mast cell targeting agents, and corticosteroids. | 2020-07-15 |
| 32663601 | Due to important methodological limitations, further studies are needed to confirm our findings and to investigate their clinical consequences. | 2020-07-15 |
| 32663787 | Other viruses in addition to SARS-CoV-2 cause cold-like symptoms and spread in the winter. […] We collected 191 nasopharyngeal swabs from patients with cold-like symptoms in Japan. […] FilmArray Respiratory Panel analysis detected at least one virus in 32 of 191 patients with cold-like symptoms (21 %). | 2020-07-15 |
| 32663788 | To assess the utility of the tests for clinical use and seroepidemiologic studies, we examined the sensitivity of commercial antibody tests from Roche, Abbott, Novatec, Virotech Siemens, Euroimmun, and Mediagnost in a prospective diagnostic study. | 2020-07-15 |
| 32663789 | Reports associating cancer, kidney disease, and stroke with COVID-19 should be carefully interpreted, not only because of the size of the samples, but also because patients could be old, have a history of smoking, or have any other clinical condition suggesting that these factors might be associated with the poor COVID-19 outcomes rather than the comorbidity itself. […] Further research regarding this relationship and its clinical management is warranted. | 2020-07-15 |
| 32663849 | HCW screened positive were questioned on their profession, symptoms, occupational and non-occupational exposures to SARS-CoV-2. | 2020-07-15 |
| 32663887 | This article provides a view of homeopathic clinical practice in the New York City area in the first few months of 2020 as the coronavirus disease 2019 (COVID-19) pandemic began to evolve in the United States. […] Key symptoms used to generate a short list of potentially curative remedies are given, and the pandemic syndrome is viewed as appearing in stages or as having various clinical manifestations each with its own main remedy. […] The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is briefly described, as are the preliminary presenting signs and symptoms of COVID-19 infection. […] Several clinical examples are given, some with positive laboratory confirmation. | 2020-07-15 |
| 32663903 | Enzyme-linked immunosorbent assays (ELISAs) are used widely in biotechnology, pharmaceutical, and clinical medicine labs. | 2020-07-15 |
| 32663933 | We report three representative case-scenarios on patients with psychiatric disorders and COVID-19 to provide a practical approach based on the existing literature and the clinical experience of an expert team in consultation-liaison psychiatry. […] If the psychopharmacological usual doses are in the low-to-median range levels, a dose change during COVID-19 drugs co-administration is not recommended, but only ECG and clinical monitoring of adverse effects and drug levels if required. […] (C) In non-SMI with depressive/anxiety symptoms, psychological support should be provided and symptoms identified and treated. […] Patients with psychiatric disorders and COVID-19 should be managed on a personalized basis considering several clinical criteria and, should not be excluded from receiving COVID-19 treatments. | 2020-07-16 |
| 32663970 | 54.2% and 58% of participants had symptoms of anxiety and depression. | 2020-07-16 |
| 32663990 | We investigated COVID-19 anxiety, general anxiety and depression symptoms, and their impact on problematic smartphone use (PSU) severity METHODS: Participants were 908 residents of a large Eastern Chinese city, surveyed from late-February to mid-March, 2020. | 2020-07-16 |
| 32664113 | Nine electronic databases: PubMed, EMBASE, Cochrane library, Web of Science (WOS), Google Scholar, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Chinese Scientific and Journal Database (VIP), Wan Fang database (Wanfang) and 2 clinical trials register platforms: Chinese Clinical Trial Registry (ChiCTR), ClinicalTrials.gov (www.ClinicalTrials.gov/) will be searched for RCTs of A&M for COVID-19. | 2020-07-16 |
| 32664116 | Although there have been several studies describing clinical and radiographic features about the novel coronavirus (COVID-19) infection, there is a lack of pathologic data conducted on biopsies or autopsies. […] Due to persistent air leak, thoracoscopies with blebs resection and pleurectomies were performed on 23rd and 16th days from symptoms onset. | 2020-07-16 |
| 32664161 | Many commonly discussed medications being used to treat COVID-19 are not without potentially harmful side effects such as heart, liver, kidney problems, or other clinical symptoms. […] Randomized controlled trials and credible clinical observations without randomization include patients diagnosed with COVID-19, and receiving western medicine treatments or acupuncture, with no restrictions on disease stage, age, sex, or ethnicity. […] Primary outcomes would be used to evaluate the mortality rate, C-reactive protein (CRP), creatine, troponin, liver enzymes (aspartate aminotransferase and alanine aminotransferase), blood pressure, clinical symptoms (including fever, fatigue, myalgia, cough, skin rash, nausea, vomiting, and diarrhea), and serum cytokine levels. | 2020-07-16 |
| 32664179 | After 19 days of isolation and antiviral treatment, his temperature returned to normal and the symptoms were relieved. | 2020-07-16 |
| 32664185 | Accumulating evidence suggests that gastrointestinal symptoms, such as diarrhea, are common among patients with COVID-19. […] It can act on the subcutaneous muscular layer, enhance the local blood circulation and tissue metabolism of the skin, thus exert its effects on digestive systems and alleviate aversive diarrhea symptoms. […] This systematic review and meta-analysis will summarize the current evidence of tuina (massage) used as an intervention for diarrhea symptoms in COVID-19. […] This proposed study will evaluate the effectiveness and safety of massage therapy for diarrhea symptoms in COVID-19 patients. […] The outcomes will include the improvement of diarrhea symptoms and adverse effect. […] This proposed systematic review will evaluate the existing evidence on the effectiveness and safety of massage therapy for diarrhea symptoms in COVID-19 patients.Dissemination and ethics: The results of this review will be disseminated through peer-reviewed publication. | 2020-07-16 |
| 32664388 | In this article, we propose a CorExQ9 algorithm that integrates a Correlation Explanation (CorEx) learning algorithm and clinical Patient Health Questionnaire (PHQ) lexicon to detect COVID-19 related stress symptoms at a spatiotemporal scale in the United States. […] The results show a strong correlation between stress symptoms and the number of increased COVID-19 cases for major U.S. cities such as Chicago, San Francisco, Seattle, New York, and Miami. | 2020-07-16 |
| 32664543 | No drug or vaccine has been approved due to the absence of evidence deriving from rigorous clinical trials. […] In this review, analysing lactoferrin properties, we propose designing a clinical trial to evaluate and verify its effect using a dual combination treatment with local, solubilized intranasal spray formulation and oral administration. | 2020-07-16 |
| 32664709 | The causes of different clinical phenotypes and incubation periods among individuals, species specificity, and cytokine storm with lymphopenia as well as the mechanism of damage to organ cells are unknown. […] According to its epidemiological and clinical characteristics, SARS-CoV-2 may be a virus with low virulence in nature that has adapted to the human species. | 2020-07-16 |
| 32664711 | Clinical symptoms and radiological findings of both viral pneumonia and lung adenocarcinoma may overlap resulting in diagnostic and clinical challenges.We present the case of a women admitted to our department presenting with an acute manifestation of coronavirus OC43 pneumonia with underlying undiagnosed lung adenocarcinoma. | 2020-07-16 |
| 32664761 | Four women had symptoms of COVID-19 during pregnancy or immediately after delivery. […] One case was transferred after diagnosis to a tertiary referral center and delivered the day after for worsening clinical conditions. | 2020-07-16 |
| 32664866 | In particular, accumulating evidence points to a substantial fraction of asymptomatic or subclinical infections, which influences our understanding of the transmission potential and severity of this emerging disease. | 2020-07-16 |
| 32664919 | We report epidemiological, clinical, and laboratory characteristics including the persistence of viral detection by polymerase chain reaction (PCR) and anti-SARS-CoV-2 antibody testing, treatments initiated, and outcomes. | 2020-07-16 |
| 32664932 | Although the majority of patients with COVID-19 have mild symptoms, some are more prone to serious outcomes, including pneumonia, acute respiratory distress syndrome (ARDS), and even death. […] Indeed, some of the clinical characteristics observed in the more severe cases of COVID-19 are reminiscent of secondary HLH (which can be triggered by infections, malignancies, rheumatological diseases, or autoimmune/immunodeficiency conditions). […] The pathogenesis and clinical symptoms of severe COVID-19 indicate that an increased inflammatory response corresponding to HLH is occurring. | 2020-07-16 |
| 32664957 | This strong overlap of risk factors for both worse PCOS cardio-metabolic manifestations and severe COVID-19 should be highlighted for the clinical practice, particularly since women with PCOS often receive fragmented care from multiple healthcare services. | 2020-07-16 |
| 32664985 | The COVID-19 pandemic is a complex global public health crisis presenting clinical, organisational and system-wide challenges. | 2020-07-16 |
| 32664991 | Analyze COVID-19 patients to determine the relationships of clinical characteristics, chest CT score, and levels of inflammatory mediators. […] Patient demographics, comorbidities, clinical findings, chest CT results, and CT scores of affected lung parenchyma were recorded. | 2020-07-16 |
| 32665039 | The study protocol has been reported in accordance with the Standard Protocol Items: Recommendations for Clinical Interventional Trials (SPIRIT) guidelines (Additional file 2). | 2020-07-16 |
| 32665040 | A range of clinical and virological secondary outcomes will also be evaluated. […] Australian New Zealand Clinical Trials Registry (ACTRN12620000445976). | 2020-07-16 |
| 32665052 | We sought to describe the clinical features of fatalities in patients with severe COVID-19. […] We conducted an Internet-based retrospective cohort study through retrieving the clinical information of 100 COVID-19 deaths from nonduplicating incidental reports in Chinese provincial and other governmental websites between January 23 and March 10, 2020. […] Fever (46.0%), cough (33.0%), and shortness of breath (9.0%) were the most common first symptoms. | 2020-07-16 |
| 32665127 | Among currently available drugs, type I Interferons (IFN-I) - mainly IFN-α and β -represent ideal candidates given their direct and immune-mediated antiviral effects and the long record of clinical use. | 2020-07-16 |
| 32665227 | The Patient Health Questionnaire-9 and the General Anxiety Disorder Scale-7 were used to screen for depressive symptoms and anxiety, respectively. […] A total of 29 (13%) caregivers had depressive symptoms, and 24 (11%) had anxiety. | 2020-07-16 |
| 32665373 | To describe the epidemiological and clinical characteristics of coronavirus disease (COVID-19) pediatric patients aged <18 years in Italy. […] Demographic and clinical characteristics of subjects were summarized by age groups (0-1, 2-6, 7-12, 13-18 years), and risk factors for disease severity were evaluated by using a multilevel (clustered by region) multivariable logistic regression model. […] Hospitalization rate, admission in ICU, disease severity, and days from symptoms onset to recovery significantly increased with age among children, adults and elderly. | 2020-07-16 |
| 32665397 | To study the correlation between gastrointestinal (GI) symptoms and disease severity in patients with COVID-19. […] In a meta-analysis of 9 studies, comprising 3022 patients, 479 patients (13.7%, 95% CI 0.125 to 0.149) had severe disease and 624 patients (14.7%, 95% CI 0.136 to 0.159) had GI symptoms. […] Of 624 patients with GI symptoms, 118 patients had severe disease (20.5%, 95% CI 0.133 to 0.276) and of 2397 cases without GI symptoms, 361 patients had severe disease (18.2%, 95% CI 0.129 to 0.235). […] Comparing disease severity of patients with and without GI symptoms, the results indicated: I²=62%, OR=1.21, 95% CI 0.94 to 1.56, p=0.13; there was no statistically significant difference between the two groups. […] Current results are not sufficient to demonstrate a significant correlation between GI symptoms and disease severity in patients with COVID-19. | 2020-07-16 |
| 32665398 | Even mild liver damage raised LS significantly in COVID-19 as it was in patients with gastrointestinal symptoms. | 2020-07-16 |
| 32665420 | Demographics, symptoms, comorbidities, treatment, and mortality of patients whose sera were used were also reviewed. | 2020-07-16 |
| 32665633 | Clinical and CT scanning data were collected. | 2020-07-16 |
| 32665783 | Besides, we also summarized the effective therapies in clinical for controlling inflammation. | 2020-07-16 |
| 32665786 | A similar clinical profile occurs in severe trauma cases. | 2020-07-16 |
| 32665788 | Breathe Chief Editor @ClaudiaCDobler on how #COVID19 amplifies flaws in clinical research and practice https://bit.ly/3cX0jpO. | 2020-07-16 |
| 32665858 | We aim to explore risk factors associated with mortality in COVID-19 patients and assess the use of D-dimer as a biomarker for disease severity and clinical outcome. […] We retrospectively analyzed the clinical, laboratory, and radiological characteristics of 248 consecutive cases of COVID-19 in Renmin Hospital of Wuhan University, Wuhan, China from January 28 to March 08, 2020. […] D-dimer levels significantly increased with increasing severity of COVID-19 as determined by clinical staging (Kendall’s tau-b = 0.374, P = 0.000) and chest CT staging (Kendall’s tau-b = 0.378, P = 0.000). | 2020-07-16 |
| 32665887 | Scarce data exist about the clinical features of COVID-19 in patients with concomitant active and/or latent tuberculosis (TB). | 2020-07-16 |
| 32665888 | With its variety of clinical manifestations including, but not limited to, fever, cough, diarrhea, vomiting, headache, myalgia and fatigue, it may be challenging to distinguish COVID-19 from a spectrum of diseases with similar presentations, such as malaria, especially in endemic areas. […] In this case, we emphasize the need for vigilance from frontline clinicians for timely diagnosis and appropriate clinical management of potential co-infections in the COVID era. | 2020-07-16 |
| 32665934 | Here we report a case of pulmonary embolism in a COVID-19 patient with an atypical clinical presentation. | 2020-07-16 |
| 32665937 | COVID-19 is the clinical expression of the highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection. […] Most patients have mild symptoms, but a significant proportion have severe or critical disease, which can include cardiac injury, sepsis, acute kidney failure and respiratory failure. […] The cutaneous clinical spectrum is wide and includes maculopapular, urticarial, varicelliform and petechial rashes, pseudo perniosis, livedo reticularis, and pityriasis rosea-like, violaceous and pustular lesions. […] SARS-CoV-2 presents with multiple symptoms with the dermatological manifestations currently under-recognized.Clinicians should be aware of patients presenting only with cutaneous symptoms, which in some cases are the initial clinical feature of COVID-19. | 2020-07-16 |
| 32665938 | The clinical course was marked by worsening of the respiratory disease, the development of right parotiditis and thrombosis of the left internal jugular vein. | 2020-07-16 |
| 32665942 | In June 2020, a large randomised controlled clinical trial in the UK found that dexamethasone was effective in reducing the number of deaths in patients with severe coronavirus disease 2019 (COVID-19). | 2020-07-16 |
| 32665963 | Then, we review the clinical symptoms, diagnosis, and treatment options of COVID-19 patients. […] Finally, we summarize clinical trials of some potential therapeutic drugs and the results of vaccine development. | 2020-07-16 |
| 32665967 | While machine learning (ML) methods have been previously used to augment clinical decisions, there is now a demand for “Emergency ML.” […] This perspective highlights the utility of evidence-based prediction tools in a number of clinical settings, and how similar models can be deployed during the COVID-19 pandemic to guide hospital frontlines and healthcare administrators to make informed decisions about patient care and managing hospital volume. | 2020-07-16 |
| 32665985 | The assay was evaluated by performing 184 validations for the SARS-CoV-2 Nucleocapsid gene and human RNase P as an internal control reference gene with dilutions ranging from 1-100 ng for human RNA on a cohort of 26 clinical samples. 5 of 26 patients were confirmed to be infected with SARS-CoV-2, while 21 tested negative, consistent with the standards. […] The accuracy of the assay was found to be 100% sensitive and 100% specific based on the 26 clinical samples that need to be further verified using a large number of clinical samples. | 2020-07-16 |
| 32666025 | The consensus covers the assessment, clinical nursing, discharge care, and other aspects of care for critically ill elderly patients with COVID-19, aiming to share insights and provide guidance for clinical practice. | 2020-07-16 |
| 32666026 | According to the epidemiology, virology, and clinical practice, there are varying degrees of changes in patients, involving the human body structure and function and the activity and participation. | 2020-07-16 |
| 32666040 | Results and Conclusion: This information will help decision makers respond rapidly to meet the clinical needs of paediatric patients as the circumstances of the pandemic unfold and reduce the disruption to normal paediatric ED services during the onset of COVID-19. | 2020-08-25 |
| 32666093 | The stakeholders included the American Academy of Clinical Neuropsychology/American Board of Clinical Neuropsychology, the National Academy of Neuropsychology, Division 40 of the American Psychological Association, the American Board of Professional Neuropsychology, and the American Psychological Association Services, Inc. | 2020-07-16 |
| 32666230 | Clinical characterization of COVID-19 (Corona Virus Disease 2019) is being performed worldwide to gain insights into the pathogenesis and course of the disease. | 2020-07-16 |
| 32666303 | In 71 patients (mean age 61, 75% men), 31 (42%) had delirium, of which only 12 (39%) had been recognised by the clinical team. | 2020-07-16 |
| 32666376 | The limitations imposed on accessibility to non-urgent care during the lockdown of “phase 1” of this pandemic have created the need to revolutionize clinical practice to meet the health demands of chronic and high-risk diseases such as obesity and diabetes. | 2020-07-16 |
| 32666395 | Basic clinical characteristics were reviewed. | 2020-07-16 |
| 32666422 | Over the course of the pandemic due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), multiple new clinical manifestations, as the consequence of the tropism of the virus, have been recognized. | 2020-07-16 |
| 32666481 | In 107 healthcare workers with symptoms of COVID-19, combined throat/nasal sampling and nasopharyngeal sampling was performed. | 2020-07-16 |
| 32666513 | Because the characteristics of the headache and the associated symptoms are heterogeneous in our survey, we suggest that several patterns with specific pathophysiological mechanisms may underlie the headache associated with COVID-19. | 2020-07-16 |
| 32666664 | The COVID-19 pandemic has reduced clinical volume with a negative impact on trainee education. […] Respondents reported a universal decrease in clinical activities (98.3%). | 2020-07-16 |
| 32666676 | Evidence-based medicine (EBM), the dominant approach to assessing the effectiveness of clinical and public health interventions, focuses on the results of association studies. | 2020-07-16 |
| 32666713 | Existing scales were adapted to measure stressful experiences, resilience, coping, social support, and ASD symptoms. […] Both direct and indirect effects from COVID-19-related stressful experiences to ASD symptoms were significant. […] The findings presented the ASD symptoms related to the COVID-19 outbreak and the mediating role of interpersonal and intrapersonal factors in the association. | 2020-07-16 |
| 32666816 | The COVID-19 pandemic presents challenges for clinical trials including urgency, disrupted infrastructure, numerous therapeutic candidates, and the need for highly efficient trial and development designs. […] Methods to create very efficient clinical trial comparisons of treatments for COVID-19 are available. | 2020-07-16 |
| 32666875 | Findings from limited autopsies, clinical observations, and laboratory data suggest that high cytokine levels and a procoagulant state can precipitate acute respiratory distress syndrome and multi-organ dysfunction syndrome in critically ill patients. […] Therapeutic plasma exchange (TPE) merits consideration in the treatment of critically ill COVID-19 patients and is an avenue for clinical trials to pursue. | 2020-07-16 |
| 32666887 | Cardiac surgical centers may experience an increasing number of COVID-19 patients in clinical practice. | 2020-07-16 |
| 32666912 | The COVID-19 pandemic has altered clinical practice and education in manual therapy globally. […] The global impact on the clinical practice of manual therapy and education has to date not been explored. a questionnaire survey methodology was used. […] A sample of convenience of global leaders in manual therapy practice and education received an electronic link to two surveys: one on clinical practice and one on education. […] Twenty-five surveys were received on clinical practice and 23 on education in manual therapy, representing the six major continents. […] Global themes in clinical practice demonstrated a sudden and dramatic shift away from patient contact, with limited modifications to manual therapy in patient care currently adopted. | 2020-07-16 |
| 32667047 | There is strong evidence that this novel coronavirus may be neuroinvasive and could cause a wide array of neurological symptoms and complications. | 2020-07-16 |
| 32667069 | The clinical characteristics of the patients were retrospectively registered, along with novel containment and infection prevention measures targeting the new coronavirus. | 2020-07-16 |
| 32667106 | The process included the following: (1) anticipate mental health needs; (2) use leadership capable of mobilizing the systems and resources; (3) convene a multidisciplinary team; (4) delegate tasks and set timelines; (5) choose a clinical service model; (6) motivate staff as a workforce of volunteers; (7) develop training and educational materials; (8) develop personal, local, and national resources; (9) develop marketing plans; (10) deliver the training; (11) launch a 24 hr/7days per week Healthcare Worker Mental Health COVID-19 Hotline, and launch follow-up sessions for staff; (12) structure data collection to determine effectiveness and outcomes; and (13) obtain funding (not required). | 2020-07-16 |
| 32667117 | On average, sample respondents report Center for Epidemiological Studies Depression (CES-D) Scale symptomatology nearly a point higher than the often used cutoff score for clinical caseness (16+); one-third of respondents had CES-D scores higher than 25. […] Those persons expressing heightened COVID-19 fear and moderate to high levels of food insecurity report more depressive symptoms than persons with less fear and low or no food insecurity. […] In a snapshot, the data provide an important point prevalence assessment of adult depressive symptoms during the current public health crisis. | 2020-07-16 |
| 32667150 | Demographic, anamnestic and clinical characteristics, laboratory exams and medical imaging findings were collected for the entire cohort. | 2020-07-16 |
| 32667207 | Rationale: Clinical and epidemiologic data in coronavirus disease (COVID-19) have accrued rapidly since the outbreak, but few address the underlying pathophysiology.Objectives: To ascertain the physiologic, hematologic, and imaging basis of lung injury in severe COVID-19 pneumonia.Methods: Clinical, physiologic, and laboratory data were collated. | 2020-07-16 |
| 32667283 | Clinical manifestations and atypical radiographic features of COVID-19 led to the diagnosis of TB through positive interferon-gamma release assay and culture results. | 2020-07-16 |
| 32667391 | There are few data on the impact of COVID-19 in pregnancy, however, analyzing these data is important to guide the clinical practice, covering the early prevention, detection, patients’ isolation, epidemiological investigation, diagnosis and early treatment. […] The three patients progressed with a severe clinical evolution of COVID-19. | 2020-07-16 |
| 32667418 | MEDLINE® and Embase databases were extensively searched for major clinical manifestations of gastrointestinal involvement in children and adolescents with COVID-19 reported in medical literature, and for nutritional therapy-related data. […] Children and adolescents with gastrointestinal symptoms, such as nausea, vomiting and diarrhea, should be seriously suspected of COVID-19. […] Gastrointestinal signs and symptoms may occur in 3% to 79% of children, adolescents and adults with COVID-19, and are more common in severe cases. | 2020-07-16 |
| 32667435 | Admissions to intensive care units have suddenly increased, but many of these patients do not present with clinical manifestations related to the viral infection but rather exacerbation of preexisting diseases. | 2020-07-16 |
| 32667444 | Prophylactic heparin should be used in hospitalized patients, however, no anticoagulation should be provided for patients without a specific clinical indication. […] So far no pharmacological intervention was proven effective and safe to warrant its use in the routine treatment of COVID-19 patients; therefore such patients should ideally be treated in the context of clinical trials. | 2020-07-16 |
| 32667574 | Containment measures involve those recommended by major health organizations, such as hand hygiene, social isolation, identification and monitoring of suspected or confirmed cases; and also the local measures implemented in the health service, such as the reduction in the number of hospitalizations for transplantation, clinical screening of outpatients entering the service, monitoring of respiratory signs and symptoms, the allocation of specific isolation rooms for those suspected of the disease and testing of symptomatic patients. | 2020-07-16 |
| 32667578 | Observational studies addressed the clinical findings of patients with COVID-19 and association between kidney damage, infection, and morbidity-mortality. the studies addressed the mechanism of intracellular infection of SARS-CoV-2, its cytopathic effects on kidney cells and incidence of acute kidney injury in patients infected with SARS-CoV-2. | 2020-07-16 |
| 32667668 | This study identified demographic, clinical, and hospital-level risk factors that may be associated with death in critically ill patients with COVID-19 and can facilitate the identification of medications and supportive therapies to improve outcomes. | 2020-07-16 |
| 32667669 | The median follow-up was 44 (95% CI, 40-47; IQR, 11-69; range, 0-100) days; median time from symptoms onset to ICU admission was 10 (95% CI, 9-10; IQR, 6-14) days; median length of ICU stay was 12 (95% CI, 12-13; IQR, 6-21) days; and median length of IMV was 10 (95% CI, 10-11; IQR, 6-17) days. | 2020-07-16 |
| 32667699 | There is a need for well-designed randomized clinical trials for further investigation of every therapeutic intervention for further insight into different therapeutic options. | 2020-07-16 |
| 32667716 | The third, fourth, and fifth patients were diagnosed on 10th, 11th, and 18th postoperative day, respectively, and presented satisfactory clinical evolution. | 2020-07-16 |
| 32667726 | 62.6 ± 12.2, p = .03) with a delayed seek to care (mean delay first symptoms-balloon 3.8 ± 3 vs. .7.4 ± 7.7, p < .001) resulting in a two-fold higher in-hospital mortality (non COVID-19 4.3% vs. | 2020-07-16 |
| 32667733 | The external validation of their performance is needed before use in clinical routine practice. […] Our study aims at assessing the analytical and clinical performance of two enzyme-linked immunosorbent assay tests detecting antibodies directed against the virus nucleocapsid protein: The NovaLisa SARS-CoV-2 immunoglobulin G (IgG), immunoglobulin A (IgA), and immunoglobulin M (IgM) test (NovaTec) allowing a separate detection of each antibody and the Platelia SARS-CoV-2 Total Ab test (Bio-Rad) detecting total antibodies (IgM, IgA, and IgG). […] The clinical performances are excellent for IgG, IgA, and total antibodies especially if the cut-off is optimized. | 2020-07-16 |
| 32668015 | The primary outcome measure was 14-day symptoms and/or SARS-CoV-2 test. […] The 51% of patients were tested during their admission for SARS-CoV-2; 5% were diagnosed/developed symptoms of SARS-CoV-2 during and until 14 days post-discharge; four were male and one female, mean age 41.2 years (range, 17-75 years), all had primary malignant bone or soft-tissue tumours, four of five had received immunosuppressive therapy pre-operatively. | 2020-07-16 |
| 32668037 | Although Coronavirus disease 2019 (COVID-19) is primarily a respiratory disease, growing evidence shows that it can affect the digestive system and present with gastrointestinal (GI) symptoms. […] In patients with COVID-19, the normal intestinal mucosa can be disrupted by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, and this could result in GI symptoms and a compromise in nutrient absorption. | 2020-07-16 |
| 32668047 | During the outbreak of the COVID-19 pandemic many clinical trials were abruptly halted. […] This opens up the discussion when and how clinical trials should be restarted while the COVID-19 pandemic has not yet resolved, and what should happen in case of a resurgence of the virus in the coming months. […] This article uses the four ethical principles framework as a structured approach to come to a set of practical, ethically grounded guidelines for halting and relaunching clinical trials during the COVID-19 pandemic. […] The framework applied provides a structured approach for all clinical trials stakeholders and thereby prevents unclear reasoning in a complex situation. […] In this article we argue that the situation for clinical trials is not essentially different from the pre-COVID-19 era and that an overcautious approach will have negative consequences. | 2020-07-16 |
| 32668062 | However, emerging evidence indicates that a small but growing number of COVID-19 patients also manifest neurological symptoms, suggesting that SARS-CoV-2 may infect the nervous system under some circumstances. | 2020-07-16 |
| 32668216 | These data demonstrate that RDV is potently active against SARS-CoV-2 in vitro and in vivo, supporting its further clinical testing for treatment of COVID-19. | 2020-07-16 |
| 32668312 | Therefore, we recommend FDA-approved-IONPs to proceed for COVID-19 treatment clinical trials. | 2020-07-16 |
| 32668399 | We analyzed the data retrospectively from 146 patients of type 2 diabetes mellitus (T2DM) reporting to the emergency department (ED) during lockdown period with symptoms suggestive of hypoglycemia. | 2020-07-16 |
| 32668444 | Memory T cells induced by previous pathogens can shape susceptibility to, and the clinical severity of, subsequent infections1. | 2020-07-16 |
| 32668462 | When caring for patients with coronavirus disease 2019 (COVID-19), clinicians have noticed some unusual clinical presentations not observed before, such as profound hypoxia and severe hypotension. […] Clinical presentations are discussed but continue to evolve as the pandemic ravages our society. | 2020-07-16 |
| 32668494 | Although the clinical features of COVID-19 related liver injury have been investigated, there have been no reports and studies on the clinical characteristics of COVID-19 patients co-infected with Hepatitis B Virus (HBV). […] All 326 confirmed COVID-19 cases in Shanghai Public Health Clinical Center (The COVID-19 designated hospital in Shanghai, China) from January 20, 2020 to February 24, 2020 were enrolled and followed up until February 29 in this study. […] The clinical, laboratory data and the length of stay were collected and analyzed retrospectively. 20 patients with HBV co-infection (6.1%) and 306 patients (93.9%) without HBV infection showed no differences in the level of liver function parameters. | 2020-07-16 |
| 32668513 | This special article introduces clinical practice guidelines to prevent secondary transmission of COVID-19 within facilities; the guidelines were developed to protect patients and healthcare workers from this highly contagious virus. | 2020-07-16 |
| 32668514 | The ultrasound findings improved as her clinical condition improved and her viral load decreased. | 2020-07-16 |
| 32668515 | Herein, we report four confirmed coronavirus disease 2019 (COVID-19) cases in the early stage of the pandemic in South Korea and describe the identification, diagnosis, clinical course, and management, including one patient’s initial mild symptoms at presentation and their progression to pneumonia on day 21 of illness. […] Re-hospitalized patients with COVID-19 PCR positive results after discharge were not related to her initial chest CT, lab, symptoms compared other three patients. | 2020-07-16 |
| 32668763 | The diversity of clinical characteristics and progress are reported in many countries as the duration of the pandemic is prolonged. […] We aimed to perform a novel systematic review and meta-analysis focusing on findings about correlations between clinical characteristics and laboratory features of patients with COVID-19. […] Clinical characteristics, laboratory findings, and treatment strategies were retrospectively reviewed for the analysis. […] Fever, cough and fatigue/myalgia were the most common symptoms of COVID-19, followed by some gastrointestinal symptoms which are also reported frequently. […] (4) Conclusions: This paper is the first systematic review and meta-analysis to reveal the relationship between various variables of clinical characteristics, symptoms and laboratory results with the largest number of papers and patients until now. […] In elderly patients, laboratory and clinical characteristics indicate a more severe disease course. | 2020-07-17 |
| 32668803 | As supported by recent clinical data, patients who have already taken lysosomotropic drugs for other pre-existing conditions likely benefit from this treatment in the COVID-19 pandemic. | 2020-07-17 |
| 32668969 | QFPDT could prevent the progression from mild cases and shorten the average duration of symptoms and hospital stay. […] It has been recommended in the 6th and 7th versions of Clinical Practice Guideline on COVID-19 in China. […] While large scale clinical studies on QFPDT are being conducted in China, one should use real world data for exploration of integrative treatment with inclusion of pharmacokinetic, pharmacodynamic and herb-drug interaction studies. | 2020-07-17 |
| 32668970 | Based on the changes in TCM diagnosis and treatment strategies in these seven versions of Diagnosis and Treatment Program for Coronavirus Disease-2019, this paper collected data reported by the Chinese government media; analyzed the understanding of the etiology, pathogenesis, syndrome differentiation, treatment methods, and prescriptions of COVID-19 by TCM and evaluated the clinical efficacy of TCM strategies. […] TCM strategies represented by Qing Fei Pai Du Tang have shown apparent advantages in improving symptoms, promoting virus clearance, and shortening hospitalization, as well as surprising efficacy of zero patient progressing from mild to severe cases in a TCM cabin hospital. […] Clinical data illustrate the effectiveness of TCM strategies proposed by the Chinese government. | 2020-07-17 |
| 32668983 | Here, we applied RT-LAMP directly on human clinical swabs and self-collected saliva samples. | 2020-07-17 |
| 32669014 | Results of laboratory tests, imaging tests, and nucleic acid tests on vaginal swabs for SARS-CoV-2 were also analyzed for pregnant women with a clinical diagnosis of COVID-19. […] All patients had mild symptoms and were followed in the maternity ward, with none of them needing critical care unit follow-up. | 2020-07-17 |
| 32669150 | After surgery, none of the patients developed signs or symptoms suspicious of COVID-19 that would indicate the need for a repeated RT-PCR or CT scan. | 2020-07-17 |
| 32669159 | Therefore, during the epidemic of COVID-19, if children have symptoms similar to Kawasaki disease, intravenous immunoglobulin is recommended as early as possible to reduce the incidence of coronary artery lesions. | 2020-07-17 |
| 32669285 | The COVID-19 pandemic has caused widespread disruption of cancer clinical trials due to the restrictions on nonessential services and the reallocation of resources, and at the same time the urgent global effort toward discovering therapies that treat or prevent COVID-19 infection has led to shortening of traditional regulatory timelines. | 2020-07-17 |
| 32669297 | Integrated analysis of ~200 immune and ~50 clinical features revealed activation of T cell and B cell subsets in a proportion of patients. […] Our analyses identified three immunotypes associated with poor clinical trajectories versus improving health. | 2020-07-17 |
| 32669390 | This Perspective explores the evolving epidemiological, clinical, biological, and molecular evidence to propose an unfolding paradigm in which old age, chronic metabolic disease (such as obesity, type 2 diabetes, and metabolic syndrome), and male biological sex produce a deadly symbiosis of dysregulated immunometabolism and chronic systemic inflammation that intensifies virally induced hyperinflammation associated with SARS-CoV-2 infection. | 2020-07-17 |
| 32669391 | We put forth the hypothesis that during this process, reduced ACE2 could result in clinical deterioration in COVID-19 patients with diabetes via aggravating Ang-II-dependent pathways and partly driving not only lung but also bone marrow and gastrointestinal pathology. […] Careful targeting of the systemic and tissue RAS may optimize clinical outcomes in subjects with diabetes infected with SARS-CoV-2. | 2020-07-17 |
| 32669467 | Here, we analyzed the clinical and immunological characteristics of 71 confirmed COVID-19 patients. […] We compared the clinical and laboratory data obtained from electronic medical records between the two types. | 2020-07-17 |
| 32669519 | With the emergence of coronavirus disease 2019 (COVID-19) in late December 2019, many clinical studies on a group of the pre-existing medications have been conducted to treat this disease. […] The purpose of this review was to compile the clinical evidences on the use of the pre-existing medications and potential therapeutic options for the management of COVID-19. […] We reviewed the literature to highlight the clinical studies on the use of these medications to be available as a scientific overview for further perspectives. […] Inadequate clinical evidences are available to be affirmed for the repurposing of old medications, and large scale clinical studies are needed to be carried out to further confirm the use of these agents. […] The clinical use of these medications should be well explained and follow the framework of Monitored Emergency use of Unregistered Interventions (MEURI) of World Health Organization (WHO). | 2020-07-17 |
| 32669540 | We show that a deep learning-based survival model can predict the risk of COVID-19 patients developing critical illness based on clinical characteristics at admission. | 2020-07-17 |
| 32669664 | In fact, the first vaccine candidate launched into clinical trials is an mRNA vaccine delivered via lipid nanoparticles. | 2020-07-17 |
| 32669866 | In this study, we assessed the characteristics of markers of the liver in patients with COVID-19 to provide new insights in improving clinical treatment. | 2020-07-17 |
| 32669979 | This systematic review analyzed whether the presence or absence of gastrointestinal symptoms in patients with SARS-COV-2 infection is associated with adverse outcomes. […] Searching the Cochrane Center Register of Controlled Trials, we included any studies looking at patients with COVID-19 with gastrointestinal symptoms (nausea, vomiting, diarrhea, abdominal pain) compared to those with COVID-19 but without gastrointestinal manifestations as a control group. […] Seven studies were identified but three were excluded: one due to lack of a control group without gastrointestinal symptoms, one reported as viral RNA in the stool, and one with only non-critically ill patients. […] Results of the meta-analysis showed a pooled odds ratio for mortality among those with COVID-19 and gastrointestinal symptoms of 0.91 (confidence interval 0.49-1.68) with heterogeneity of 0% and a pooled odds ratio for acute respiratory distress syndrome of 2.94 (confidence interval 1.17-7.40) with heterogeneity of 0%. […] In conclusion, gastrointestinal symptoms with COVID-19 are associated with a higher risk of acute respiratory distress syndrome, but do not increase the risk for mortality. | 2020-07-17 |
| 32670066 | Based on national clinical trials of novel treatments, China, Italy, Germany, and other countries and organizations have published multiple guidelines for COVID-19 and advised many medicines, such as chloroquine and tocilizumab. | 2020-07-17 |
| 32670100 | Reasons for calling were anxiety symptoms (n=73, 49%), request for hotline information (n=31, 20.8%), worries about Covid-19 (n=23, 15.44%), exhaustion (n=17, 11.41%), trauma reactivation (n=10, 6.11%), insomnia (n=9, 6.0%), anger (n=8, 5.37%), depressive (n=6, 4.02%), and psychotic symptoms (n=3, 2.01%). | 2020-07-17 |
| 32670172 | Moreover, results of multiple regression showed that the isolation policy has had a complex influence on the symptoms of obsessive-compulsive disorder [F(12, 979) = 44.894, p < 0.001], fear [F(12, 979) = 30.776, p < 0.001], hypochondria [F(12, 979) = 22.530, p < 0.001], depression [F(12, 979) = 39.022, p < 0.001], and neurasthenia [F(12, 979) = 45.735, p < 0.001] via various factors. | 2020-07-17 |
| 32670439 | A 19-year-old healthy female COVID-19 virus carrier without any symptoms caused two mild and one severe pneumonia. | 2020-07-17 |
| 32670441 | This study was performed to analyze information regarding the transmission route and presence of viral nucleic acids on several clinical samples. […] Five cases showed severe symptoms, and the remaining ones showed mild manifestations. | 2020-07-17 |
| 32670520 | A variety of signs and symptoms may be present, and infections can range in severity from the common cold and sore throat to more serious laryngeal or tracheal infections, bronchitis, and pneumonia. […] Children appear to be less susceptible to develop severe clinical disease and present usually with mild and aspecific symptoms similar to other respiratory infections typical of childhood. […] The purpose of this review is to provide to clinicians a complete and updated panel useful to recognize and characterize the broad spectrum of clinical manifestations of coronavirus infections in the pediatric age. | 2020-07-17 |
| 32670522 | We report a severe case of COVID-19 in a patient with chronic lymphocytic leukemia and describe primarily the clinical presentation and the challenges encountered in the COVID-19 diagnosis, treatment, and specimens sampling pitfalls. | 2020-07-17 |
| 32670524 | This study aims to investigate, retrospectively, the epidemiological and clinical characteristics, laboratory results, radiologic findings, and outcomes of COVID-19 in patients with transfusion-dependent β thalassemia major (TM), β-thalassemia intermedia (TI) and sickle cell disease (SCD). […] Clinical, laboratory, and radiologic findings and outcomes of patients with COVID-19 were collected from medical records and summarized. […] A rapid clinical improvement of tachypnea/dyspnea and oxygen saturation was observed, after red blood cell exchange transfusion, in a young girl with SCD and worsening of anemia (Hb level from 9.2 g/dl to 6.1g/dl). […] The data presented in this survey permit an early assessment of the clinical characteristics of COVID 19 in different countries. 70% of symptomatic patients with COVID- 19 required hospitalization. | 2020-07-17 |
| 32670680 | Thus far, there is limited information available on the etiology, clinical outcomes, and management options for cardiovascular complications caused by COVID-19. […] This review focuses on literature published in year 2020 on the virus-induced cardiovascular damage with intention to better understand pathophysiology of this process, its impact on clinical outcomes, and available therapies. | 2020-07-17 |
| 32670785 | Our experience underlines the importance of the use of a multidisciplinary therapeutic approach in order to achieve a favorable clinical outcome. | 2020-07-17 |
| 32670829 | Global pandemic of COVID-19 is a serious unmet medical need requiring clinical research into effective therapies. […] Clinical trials during pandemics of infections face complex challenges of putting scientific and ethical principles into practice. […] Some of these issues - selection of investigational product and participants, study design, assessment of efficacy and safety, ethics review, informed consent and publication, sample size, and publications - require in-depth consideration in planning and implementation of clinical trials during pandemics. | 2020-07-17 |
| 32670924 | Patients with a potential SARS-CoV-2 exposure present with symptoms of low-grade pyrexia, dry cough, or shortness of breath. […] People with these symptoms should contact health-care providers before seeking medical intervention so that appropriate preventive actions may be implemented. | 2020-07-17 |
| 32670925 | It includes the evidence-based information on epidemiological determinants (agent, host, and environment) of the disease, its clinical features, clinical and laboratory diagnosis, basic infection prevention and control measures, and clinical management of COVID-19 cases. | 2020-07-17 |
| 32670990 | We describe the clinical features and role of ultra-low-dose chest computed tomography (CT) and bronchoscopy in the diagnosis of coronavirus disease (COVID-19). […] Clinical and laboratory findings in COVID-19 are unspecific.Chest CT has a diagnostic sensitivity comparable to nasopharyngeal swab RT-PCR assay but lacks specificity.RT-PCR assays on biological specimens, particularly nasopharyngeal swabs, are considered the diagnostic gold standard.Bronchoscopy and bronchoalveolar lavage can help confirm the diagnosis and should be performed in patients in whom diagnostic-driven treatment for COVID-19, such as tocilizumab or remdesivir, is being considered. | 2020-07-17 |
| 32671013 | Clinical symptoms suggest SARS-CoV-2 infection with typical ground glass like a lung in computed tomography. | 2020-07-17 |
| 32671082 | This is an essential clinical characteristic, as it can factor into a patient’s clinical management and preventative measures. […] Some clinical studies have shown disparities in the proportion between males and females that have more severe clinical outcomes or, subsequently, die from this disease. […] The results of this meta-analysis indicated that males constituted a significantly higher proportion of those who had adverse clinical outcomes and died from COVID-19. […] Early identification and appropriate medical care for males with lab-confirmed COVID-19 may substantially change the course of clinical prognosis, resulting in greater numbers of lives saved. | 2020-07-17 |
| 32671086 | The main clinical manifestation is pneumonia. […] We reviewed the literature to highlight the typical manifestations and advantages of chest computed tomography and lung ultrasound in COVID-19 pneumonia in order to assist clinical researchers in the management of this disease. | 2020-07-17 |
| 32671115 | In this review, we highlight the epidemiology, transmission, symptoms, and treatment of this disease, as well as future strategies to manage the spread of this fatal coronavirus. | 2020-07-17 |
| 32671131 | The participants were randomized (range) at 4 (2-5) days after onset of symptoms. | 2020-07-17 |
| 32671432 | Two of them showed a change of their clinical status, due to a worsening of COVID-19 symptoms, so the surgical option was postponed. | 2020-07-17 |
| 32671609 | COVID-19 coagulopathy linked to increased D-dimer levels has been associated with high mortality (Fei Z et al. in Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. | 2020-07-17 |
| 32671650 | Most patients (~85%) develop no or mild symptoms, while others become seriously ill, some succumbing to disease-related complications. […] In this review, the SARS-CoV‑2 life cycle, its transmission and the clinical and immunological features of COVID-19 are described. | 2020-07-17 |
| 32671688 | Numerous investigators are developing novel protease inhibitors, some of which have made it into clinical trials. | 2020-07-17 |
| 32671732 | To determine the differences by age-dependent categories in the clinical profile, presentation, management, and short-term outcomes of patients with laboratory-confirmed COVID-19 admitted to a Spanish Emergency Department (ED). […] Demographic, baseline and acute clinical data, and in-hospital and 30-day outcomes were collected. 1379 confirmed COVID-19 cases (mean age 62 (SD 18) years old; 53.5% male) were included (18.1% < 45 years; 17.8% 45-54 years; 17.9% 55-64 years; 17.2% 65-74 years; 17.0% 75-84 years; and 11.9% ≥ 85 years). […] A statistically significant association was found between demographic, comorbidity, clinical, radiographic, analytical, and therapeutic variables and short-term results according to age-dependent categories. […] There were less COVID-specific symptoms and more atypical symptoms among older people. […] Older age is associated with less COVID-specific symptoms and more atypical symptoms, and poor short-term outcomes. | 2020-07-17 |
| 32671829 | Moreover, clinical trials on the use of zinc alone or in addition to other drugs in the prophylaxis/treatment of COVID-19 are ongoing. | 2020-07-17 |
| 32671840 | The aims of this work were 1) to investigate whether office laryngoscopy is an aerosol-generating procedure with an optical particle sizer (OPS) during clinical simulation on healthy volunteers, and 2) to critically discuss methods for assessment of aerosolizing potentials in invasive interventions. […] Prospective quantification of aerosol and droplet generation during clinical simulation of rigid and flexible laryngoscopy. | 2020-07-17 |
| 32671968 | This rapid review synthesizes the literature and includes input from clinical experts to provide evidence-based guidance for surgical services. […] Pertinent findings were discussed by a working group of clinical experts, and consensus recommendations, consistent with Australian and New Zealand Government guidelines, were formulated. | 2020-07-17 |
| 32671970 | The aim of the study was to systematically review current studies reporting on clinical outcomes in people living with HIV (PLHIV) infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] Three themes were identified: (1) controlled HIV infection does not appear to result in poorer COVID-19 outcomes, (2) more data are needed to determine COVID-19 outcomes in patients with AIDS and (3) HIV-infected patients presenting with COVID-19 symptoms should be investigated for superinfections. | 2020-07-17 |
| 32671974 | Most patients (55.3%) did not meet contemporaneous criteria for testing and most (57.6%) had mild or no (13.4%) symptoms. | 2020-07-17 |
| 32672061 | During a disease outbreak/pandemic situation such as COVID-19, researchers are in a prime position to identify and develop peptide-based therapies, which could be more rapidly and cost-effectively advanced into a clinical setting. | 2020-07-17 |
| 32672149 | We conducted an external quality assessment study with inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) samples to support clinical laboratories with a proficiency testing option for molecular assays. […] To analyse SARS-CoV-2 testing performance, we used an online questionnaire developed for the European Union project RECOVER to assess molecular testing capacities in clinical diagnostic laboratories. | 2020-07-17 |
| 32672430 | Patients received, at the admission to the ED, a diagnostic work-up including: patient history, clinical examination, an arterial blood gas analysis (whenever possible performed on room air), laboratory blood tests, including serum concentrations of interleukin-6 (IL-6), lung ultrasound examination and a computed tomography (CT) scan of the thorax. | 2020-07-17 |
| 32672454 | Indeed, emergency clinical trials have been launched to assess the effectiveness of many marketed drugs, tackling the decrease of viral load through several mechanisms. | 2020-07-17 |
| 32672789 | Cough (30.0 %) was the most common initial symptom, whereas anosmia and ageusia were the first symptoms in 14.7% and 15.7% of the patients, respectively. […] Overall, 25 patients (22.5%) reported having no symptoms at admission and 7 (6.3%) remained asymptomatic at discharge. | 2020-07-17 |
| 32672790 | Here we demonstrate that sFlt-1 plasma levels correlate with respiratory symptoms severity, expression of endothelial dysfunction biomarker and incidence of organ failure in COVID-19 patients. | 2020-07-17 |
| 32672799 | The authors report that a rapid laboratory test, the eosinophil count, readily obtained from a routine complete blood cell count (CBC), may provide actionable clinical information to aid in the early recognition of COVID-19 in patients, as well as provide prognostic information. | 2020-07-17 |
| 32672840 | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was found in the intestines and feces, but its clinical significance is not completely clear. […] Epidemiological, clinical, and laboratory data were obtained. | 2020-07-17 |
| 32672843 | When facing acute neurological abnormalities during an infectious episode it is often difficult to disentangle neurological symptoms induced by the brain infection and those due to the impact of host immune response on the CNS. […] Our ability to come up with hypotheses about the mechanisms by which the virus might interact with the CNS may help to keep in mind that all neurological symptoms observed during COVID-19 do not always rely on CNS viral invasion. | 2020-07-17 |
| 32672844 | There is limited data on the clinical presentation and predictors of mortality in the African-American (AA) patients hospitalized with coronavirus disease 2019 (COVID-19) despite the disproportionately higher burden and mortality. […] The aim of this study is to report on the clinical characteristics and the predictors of mortality in hospitalized AA patients with COVID-19 infection. […] Demographics, clinical presentation, baseline co-morbidities, and laboratory data were compared between survivors and non-survivors. […] The most common presenting symptoms were cough, myalgia, fever/chills, shortness of breath, and gastrointestinal symptoms (nausea, vomiting, diarrhea, and abdominal pain), with a prevalence of 62.50%, 43.87%, 53.68%, and 27.21%, respectively. […] Cough, shortness of breath, fever/chills, gastrointestinal symptoms, and myalgia were the predominant presentation among AAs hospitalized with COVID-19 infection. | 2020-07-17 |
| 32672860 | Clinical status from day 0 (first TCZ dose) through day 14 was assessed by a 6-point ordinal scale. […] The primary outcome was clinical improvement (hospital discharge and/or a decrease of ≥2 points on the 6-point scale) by day 7. […] Secondary outcomes included clinical improvement by day 14 and dynamics of vital signs and laboratory values. […] Rates of clinical improvement by days 7 and 14 were 44.3% (39/88) and 73.9% (65/88). […] Previous or concomitant receipt of subcutaneous interferon-β (adjusted odds ratio [aOR]: 0.23; 95% confidence interval [CI]: 0.06-0.94; P = .041) and serum lactate dehydrogenase more than 450 U/L at day 0 (aOR: 0.25; 95% CI: 0.06-0.99; P = .048) were negatively associated with clinical improvement by day 7. | 2020-07-17 |
| 32673060 | Symptoms and severity at baseline and then at days 3, 5, 10, and 14 using a 10-point visual analogue scale. […] Of these, 341 (81%) had laboratory-confirmed infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or epidemiologically linked exposure to a person with laboratory-confirmed infection; 56% (236 of 423) were enrolled within 1 day of symptoms starting. […] At 14 days, 24% (49 of 201) of participants receiving hydroxychloroquine had ongoing symptoms compared with 30% (59 of 194) receiving placebo (P = 0.21). | 2020-07-17 |
| 32673081 | They provide background on three separate data gathering initiatives that have collaborated to keep their reporting structures comparable in order to “improve clinical practice in real time”: one for detailed case reports, a second via a registry, and the third an observational study that provides quantitative and qualitative data regarding clinical reasoning and patient response. | 2020-07-17 |
| 32673163 | The stakeholders included the American Academy of Clinical Neuropsychology/American Board of Clinical Neuropsychology, the National Academy of Neuropsychology, Division 40 of the American Psychological Association, the American Board of Professional Neuropsychology, and the American Psychological Association Services, Inc. | 2020-07-17 |
| 32673190 | Correlation with presenting symptoms and outcomes was computed. […] Fisher exact tests were used to compare patients who tested positive for COVID-19 with patients who tested negative for COVID-19 regarding the presence of clots and presenting symptoms. […] Patients with COVID-19 who presented with symptoms of leg ischemia only were more likely to avoid amputation or death than patients who also presented with pulmonary or systemic symptoms (P = .001). | 2020-07-17 |
| 32673191 | Secondary outcome was a composite adverse clinical outcome of intubation, ICU admission, or death. | 2020-07-17 |
| 32673296 | Information about symptoms among U.S. […] Among 57 hospitalized adult patients (aged ≥18 years), 39 (68%) reported all three of these symptoms, compared with 25 (31%) of the 81 nonhospitalized adult patients. […] Gastrointestinal (GI) symptoms and other symptoms, such as chills, myalgia, headache, and fatigue, also were commonly reported, especially after expansion of testing guidelines. […] To aid prompt recognition of COVID-19, clinicians and public health professionals should be aware that COVID-19 can cause a wide variety of symptoms. | 2020-07-17 |
| 32673298 | Understanding the demographic and clinical characteristics of decedents could inform medical and public health interventions focused on preventing COVID-19-associated mortality. | 2020-07-17 |
| 32673300 | On May 12, 2020 (day 0), a hair stylist at salon A in Springfield, Missouri (stylist A), developed respiratory symptoms and continued working with clients until day 8, when the stylist received a positive test result for SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19). […] A second hair stylist (stylist B), who had been exposed to stylist A, developed respiratory symptoms on May 15, 2020 (day 3), and worked with clients at salon A until day 8 before seeking testing for SARS-CoV-2, which returned a positive result on day 10. […] A total of 139 clients were directly serviced by stylists A and B from the time they developed symptoms until they took leave from work. […] None of these stylists reported COVID-19 symptoms. […] After public health contact tracings and 2 weeks of follow-up, no COVID-19 symptoms were identified among the 139 exposed clients or their secondary contacts. | 2020-07-17 |
| 32673355 | Clinical studies are warranted to further elucidate the safety and efficacy of UVA in humans. | 2020-07-17 |
| 32673499 | Importantly, the newly established cutoff levels of COVID-19-associated cardiac biomarkers may serve as useful criteria for the future prospective studies and clinical trials. | 2020-07-17 |
| 32673648 | Demographics and clinical data of all patients with confirmed DVT were recorded. | 2020-07-17 |
| 32673651 | A severe clinical course of COVID-19 was defined by hospitalization in the intensive care unit (ICU) and/or invasive mechanical ventilation. | 2020-07-17 |
| 32673697 | With the clinicians occupied in COVID management, a strategy of using telemedicine and engaging a team of para-clinical doctors was devised. | 2020-07-17 |
| 32673837 | It is observed that the studies pertaining to virology, diagnosis and treatment, clinical features etc. have received highest citations than general studies on epidemiology or pandemic. | 2020-07-17 |
| 32673930 | The anxiety-related disorders group exhibited higher COVID Stress Scales total scores and higher scores on its fears about danger and contamination, socioeconomic consequences, xenophobia, and traumatic stress symptoms scales than the other groups. […] The mood disorders group had higher scores on the traumatic stress symptoms and socioeconomic consequences scales than those with no current mental disorder. […] People with anxiety-related or mood disorders were more negatively affected by COVID-19 compared to those with no mental health disorder; however, adding to psychological burden, those with anxiety-related disorders reported greater fears about danger and contamination, socioeconomic consequences, xenophobia, and traumatic stress symptoms than the other groups. | 2020-07-17 |
| 32674001 | Clinical, radiological and microbiological characteristics are reported together with histopathological findings. | 2020-07-17 |
| 32674071 | Logistic regression analysis and Cox proportion Hazard models including demographic characteristics and comorbidities were carried out to predict the endpoints within 30 days from the onset of symptoms. | 2020-07-17 |
| 32674126 | Eligible Covid-19 cases were non-hospitalized adult patients with recently confirmed SARS-CoV-2 infection and less than five days of symptoms. […] Study outcomes were the reduction of viral RNA load in nasopharyngeal swabs up to 7 days after treatment start, patient disease progression using the WHO scale up to 28 days, and time to complete resolution of symptoms. […] 5.9%, intervention; RR 0.75 [0.32;1.77]) nor shortened the time to complete resolution of symptoms (12 days, control vs. 10 days, intervention; p = 0.38). | 2020-07-17 |
| 32674170 | In this review, clinical characteristics, epidemiology, diagnosis, and management of pediatric COVID-19 pneumonia based on the recent literature are discussed. | 2020-07-17 |
| 32674190 | On day 7 since onset of symptoms, the patient had fever, cough, rheumatic pain, dyspnea as well as severe hypoxemic respiratory failure (PaO2 49,9 mmHg, PaCO2 35,7 mmHg, Horovitz-Index 130). | 2020-07-17 |
| 32674206 | Disease progression and treatment with hydroxychloroquine and azithromycin ere associated with increased all-cause 30-day mortality in patients with cancer compared with patients either in remission or with no evidence of disease, according to data presented during a 2020 American Society of Clinical Oncology Virtual Scientific Program press briefing. | 2020-07-17 |
| 32674214 | Many patients with cancer rely on clinical trials to receive their oncologic care, but the routine conduct of clinical trials has substantially changed because of the COVID-19 pandemic. | 2020-07-17 |
| 32674215 | These changes have helped guide health care providers in prioritizing clinical management of patients with cancer: identifying situations in which urgent intervention is needed and those that can be triaged until the risk of infection has lessened. | 2020-07-17 |
| 32674217 | Many patients with cancer rely on clinical trials to receive their oncologic care, but the routine conduct of clinical trials has substantially changed because of the COVID-19 pandemic. | 2020-07-17 |
| 32674306 | Understanding the clinical presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and prognosis in children is a major issue. […] Children often present mild symptoms, and some severe forms require paediatric intensive care, with in some cases a fatal prognosis. […] Our aim was to identify the epidemiological characteristics, clinical presentation, and prognosis of children with coronavirus disease 2019 (Covid-19) hospitalized in Paris suburb hospitals. […] In this prospective, observational, multicentre study, we included children hospitalized in paediatric departments of Paris suburb hospitals from 23 March 2020 to 10 May 2020, during the national lockdown in France with confirmed SARS-CoV-2 infection (positive RNA test on a nasopharyngeal swab) or highly suspected infection (clinical, biological, and/or radiological data features suggestive for SARS-CoV-2 infection). […] The symptoms ranged from rhinorrhoea (34.4%) and gastrointestinal (35.5%) to respiratory distress (25%). […] For children in Paris suburbs, most cases of Covid-19 showed mild or moderate clinical expression. | 2020-07-18 |
| 32674450 | Starting with the description of our case series, we evaluated the clinical presentation and evolution of COVID-19. […] This article is addressed particularly to physicians caring for patients with COVID-19 in their clinical practice. […] Asymptomatic patients should be followed to evaluate the appearance of symptoms. […] Patients with mild symptoms lasting more than a week, and without evidence of pneumonia, can be managed at home. […] Patients with evidence of pulmonary involvement, especially in patients over 60 years of age, and/or with a comorbidity, and/or with the presence of severe extrapulmonary manifestations, should be admitted to a hospital for careful clinical-laboratory monitoring. | 2020-07-18 |
| 32674479 | The aim of this study was to investigate the prevalence of the clinical features of the SARS-CoV-2 infection in Romanian population through a novel online survey. […] We determined reasonable reliability of the survey section for clinical features of SARS-CoV-2 infection (Cronbach’s Alpha 0.671). […] We separated two significant clusters of items, each measuring a distinct factor: the sociodemographic characteristics linked to social distancing and the relevant clinical features of SARS-CoV-2 infection. […] Through binomial logistic regression analysis, we identified a statistically significant prediction model for the presumptive diagnostic of some relevant clinical features of SARS-CoV-2 infection. | 2020-07-18 |
| 32674594 | While improvement in mortality would provide unquestionable evidence about the clinical significance of a treatment, sample sizes for a study evaluating mortality are large and may be impractical, particularly given a multitude of putative therapies to evaluate. […] Clinical severity scores have been proposed as an alternative. […] Outcomes measured at fixed time points, such as a comparison of severity scores between treatment and control at day 14, may risk missing the time of clinical benefit. | 2020-07-18 |
| 32674637 | The aim was to evaluate the quality of sleep (QoS) and health-related quality of life (HRQoL), among health care professionals treating patients with COVID-19, as well as quantifying the magnitude of symptoms of depression and levels of anxiety. […] Poor QoS and HRQoL correlated with high health anxiety and severe depressive symptoms and several demographic characteristics. | 2020-07-18 |
| 32674646 | Symptoms onset was reported as on pregnancy for 12 cases, postpartum for 3 cases, and during the cesarean section for 1 case (missing data for 4). | 2020-07-18 |
| 32674815 | VA guidance to CLCs directed daily clinical screening for COVID-19 that included temperature assessment. | 2020-07-18 |
| 32674818 | The objective of this study was to explore the association of ACEi/ARB and/or statins with clinical manifestations in COVID-19-infected older adults residing in nursing homes. […] We undertook a retrospective multicenter cohort study to analyze the association between ACEi/ARB and/or statin use with clinical outcome of COVID-19. […] The outcomes were (1) serious COVID-19 defined as long-stay hospital admission or death within 14 days of disease onset, and (2) asymptomatic (ie, no disease symptoms in the whole study period while still being diagnosed by polymerase chain reaction). […] We found a statistically significant association between statin intake and the absence of symptoms during COVID-19 (odds ratio [OR] 2.91; confidence interval [CI] 1.27-6.71), which remained statistically significant after adjusting for covariates (OR 2.65; CI 1.13-6.68). […] Although the effects of statin intake on serious clinical outcome were in the same beneficial direction, these were not statistically significant (OR 0.75; CI 0.24-1.87). […] There was also no statistically significant association between ACEi/ARB and asymptomatic status (OR 2.72; CI 0.59-25.1) or serious clinical outcome (OR 0.48; CI 0.10-1.97). […] Our data indicate that statin intake in older, frail adults could be associated with a considerable beneficial effect on COVID-19 clinical symptoms. […] The role of statins and renin-angiotensin system drugs needs to be further explored in larger observational studies as well as randomized clinical trials. | 2020-07-18 |
| 32674821 | Frailty was graded according to the Rockwood Clinical Frailty Scale (CFS). […] Demographic, biochemical, and radiologic variables, comorbidities, symptoms, and treatment were extracted from electronic medical records. | 2020-07-18 |
| 32674822 | COVID-19 infection prevention and control (IPC) measures were implemented in all residents and HCP with positive testing or with COVID-19 symptoms. […] Symptoms were serially recorded in residents and HCP. […] These 2 residents had typical COVID-19 symptoms before and after testing and 2/5 HCP were asymptomatic before and after testing. […] It suggests implementing COVID-19 IPC in both residents and HCP with positive testing or COVID-19 symptoms and warns that asymptomatic HCP with repeated negative rRT-PCR testing can develop antibodies against SARS-CoV-2. | 2020-07-18 |
| 32674929 | In this paper we discuss the background, clinical evidence, pharmacology and methodological issues related to this clinical trial. | 2020-07-18 |
| 32675000 | Information regarding symptoms was collected and all patients were simultaneously tested using two RDTs (Combined - cRDT and Differentiated - dRDT). | 2020-07-18 |
| 32675033 | We aimed to investigate clinical symptoms and epidemiologic features of emergency surgery patients infected with the 2019 novel coronavirus disease (COVID-19). […] To date, however, no literature has focused on the clinical symptoms of emergency surgery patients with COVID-19 pneumonia. […] The associated clinical, laboratory, epidemiologic, demographic, radiologic, and outcome data were collected and analyzed. […] The associated main clinical symptom included fever (93 [56.7%])，dry cough (56 [34.2%]), fatigue (86 [52.4%]), nausea (78 [47.6%]), and dizziness (77 [47%]). […] The pathologic clinical symptoms investigated included fever (54 [100%]), fatigue (48 [88.9%]), nausea (52 [96.3%]), dizziness (46 [85.2%]), and dry cough (44 [81.5%]). […] In our study, the clinical symptoms of emergency surgery patients infected with COVID-19 displayed marked differences from those reporting common COVID-19 pneumonia. | 2020-07-18 |
| 32675129 | The clinical implications of COVID-19 in pregnancy remain unknown. […] In this brief report, we present a case of COVID-19 in a pregnant patient with severe respiratory compromise, whose clinical status significantly improved after caesarean delivery. | 2020-07-18 |
| 32675211 | In the first round, consensus was achieved on 13 recommendations based upon indirect evidence and clinical experience. | 2020-07-18 |
| 32675217 | Clinical, imaging, laboratory and TTE findings were compared in patients with versus without PH (estimated systolic pulmonary artery pressure >35 mm Hg) and with versus without RVD (tricuspid annular plane systolic excursion <17 mm or S wave <9.5 cm/s). […] Among hospitalised non-ICU patients with COVID-19, PH (and not RVD) was associated with signs of more severe COVID-19 and with worse in-hospital clinical outcome. | 2020-07-18 |
| 32675312 | Modestly sized case series have described clinical factors associated with COVID-19, while ACE2 and TMPRSS2 expression analyses have been described in some cell types. […] We correlated gene expression with clinical factors (including but not limited to age, gender, race, body mass index, and smoking history), HLA genotype, immune gene expression patterns, cell subsets, and single-cell sequencing as well as commensal microbiome. […] No clinical factors were consistently identified to be significantly associated with gene expression levels though outlier organ systems were observed for some factors. […] We performed a large-scale integration of ACE2 and TMPRSS2 gene expression across clinical, genetic, and microbiome domains. | 2020-07-18 |
| 32675499 | The virus, SARS-CoV-2 can cause a range of symptoms ranging from mild through fulminant respiratory failure. | 2020-07-18 |
| 32675507 | This global survey elucidates the role of pancreatic surgery during the COVID-19 pandemic, regarding patient selection for the surgical and oncological treatment of pancreatic diseases to support clinical decision-making and creating a starting point for further discussion. | 2020-07-18 |
| 32675512 | The commonest criteria to prioritize surgery were tumor biology (80%), time interval from neoadjuvant therapy (61%), risk of becoming unresectable (57%), and tumor-related symptoms (52%). | 2020-07-18 |
| 32675581 | Sociodemographic, clinical and HIV-associated characteristics were collected. | 2020-07-18 |
| 32675661 | Although the majority of patients who become infected with SARS-CoV-2 are asymptomatic or have mild symptoms, some patients develop severe symptoms that can permanently detract from their quality of life. | 2020-07-18 |
| 32675664 | We performed a review of the existing literature regarding COVID-19 and prior viral outbreaks to help guide clinical practice in terms of how to safely perform medically necessary orthopaedic procedures during the pandemic for both asymptomatic patients and high-risk (e.g., COVID-19-positive) patients. | 2020-07-18 |
| 32675668 | The number of hospitalizations decreased by 41.2% (from 2,365 ± 243 to 1,391 ± 53 per week; p < 0.001), whereas clinical outpatient visits decreased by 29.4% (from 11,693 ± 2,240 to 8,261 ± 1,104 per week; p < 0.001). | 2020-07-18 |
| 32675706 | We present four cases of coronavirus disease 2019 ischemic strokes occurring in patients aged 37-68 yrs with varying coronavirus disease 2019 infection severities, premorbid risk factors, clinical presentations (eg, focal and nonfocal), and vascular distributions. […] Because of the variable presentation of coronavirus disease 2019 ischemic strokes, clinicians can consider neuroimaging as part of the evaluation in coronavirus disease 2019 patients with either acute focal or nonfocal neurologic symptoms. […] Additional studies are needed to clarify prothrombotic state duration, determine prognosis for recovery, and establish the physiatrist’s role in long-term disease management. | 2020-07-18 |
| 32675713 | During the first period, patients were only tested because of epidemiological criteria or clinical suspicion based on fever, respiratory symptoms, or radiological findings. […] In total, 9 (15.8%) patients without clinical or radiological findings tested positive at any moment. […] Clinical symptoms demonstrated high specificity (92.1%) but poor sensitivity (52.6%) for infection detection. […] Negative clinical symptoms do not rule out infection. | 2020-07-18 |
| 32675717 | Currently, there is a large debate on the use of antimalarials for prophylaxis and treatment of SARS-CoV-2-induced disease based on preclinical in-vitro data, small case series and extrapolation from earlier studies of their effect on intracellular pathogens, including many viruses. […] Especially immunomodulatory effects of antimalarials might also contribute to a clinical efficacy. […] In-vitro data provide a theoretical framework for an efficacy of antimalarials in SARS-CoV-2-induced disease but clinical proof is currently missing. | 2020-07-18 |
| 32675771 | This study presents epidemiologic and clinical features of COVID-19 infected PLWH in Detroit, Michigan. […] Although the clinical spectrum of COVID-19 among PLWH cannot be fully ascertained by this report, it adds to the data that suggest that HIV-positive patients with SARS-CoV-2 infection are not at a greater risk of severe disease or death as compared to HIV-negative patients. | 2020-07-18 |
| 32676039 | The majority of patients affected by COVID-19 complained only slight symptoms: fatigue, myalgia or cough, but more than 15% of Chinese patients progressed into severe complications, with acute respiratory distress syndrome (ARDS), needing intensive treatment. […] The Italian Society of Clinical Hemorheology and Microcirculation was aimed to highlight the role of microcirculatory dysfunction in the pathogenetic mechanisms of COVID-19 during the spreading of the biggest challenges to the World Health. | 2020-07-18 |
| 32676052 | Importance: Some of the symptoms of COVID-19 are fever, cough, and breathing difficulty. […] However, the mechanism of the disease, including some of the symptoms such as the neurological and musculoskeletal symptoms, is still poorly understood. […] Objective: The aim of this review is to summarize the evidence on the neurological and musculoskeletal symptoms of the disease. […] The key search terms used were “coronavirus” and “signs and symptoms.” […] Conclusion and Relevance: Patients with COVID-19 present with neurological and musculoskeletal symptoms. | 2020-07-18 |
| 32676257 | By day 4, the patient had marked response to treatment with platelet recovery to 105 K/µL and subsequently discharged by day 5 with complete resolution of symptoms and platelet count of 146 K/µL. | 2020-07-18 |
| 32676371 | Chest radiography (CXR) is performed more widely and readily than CT for the management of coronavirus disease (COVID-19), but there remains little data on its clinical utility. […] CRS between the 6th and 10th day from the onset of symptoms (CRSD6-10) ≥5 had a sensitivity of 89% and specificity of 95% in predicting the need for oxygen, and 100% sensitivity and 86% specificity in predicting the need for mechanical ventilation. […] A benign clinical course was seen in CXR that were normal or had very mild abnormalities. | 2020-07-18 |
| 32676372 | Statistical analyze showed that the subpleural area is the priority distribution location (14/14) and the sign inclined to perform in those patients in a relatively early stage (6/8) and with moderate clinical severity (8/8). […] The lesions of COVID-19 pneumonia distributed mainly in the back-lung segments, which characteristic may light new ideas in clinical treatment and nursing strategy. | 2020-07-18 |
| 32676657 | A total of 5 contacts reported COVID-like-symptoms at the time of the investigation and another 5 developed symptoms during the 14-day quarantine period and all were directed to self-isolate. | 2020-07-18 |
| 32676882 | The typical symptoms of COVID-19 mimic those of the common season flu. | 2020-07-18 |
| 32676883 | Recent retrospective clinical studies have established a significant association between the incidence of vascular thrombotic events and the severity of COVID-19. […] Besides, this article reviews the role of pro-inflammatory or anti-inflammatory cytokines, whose significant elevations in their serum levels have been consistently detected in multiple different clinical studies, in promoting the hypercoagulable state. | 2020-07-18 |
| 32676935 | However, the disease should not be overlooked since the associated thyrotoxicosis may worsen the clinical course of concomitant disorders (e.g., respiratory distress) and long-term sequelae, such as autoimmune hypothyroidism, have been reported. […] Coronavirus disease (COVID-19) symptoms were mild and the patient was managed with no specific treatment and recovered rapidly. […] Under the corticosteroid therapy, there was progressive resolution of symptoms and signs, and, within 4 weeks, all thyroid functional tests and inflammatory indexes normalized. | 2020-07-18 |
| 32677007 | This case report describes immune thrombocytopenic purpura in a 41-year-old man hospitalized in the intensive-care unit for COVID-19, 13 days after the onset of COVID-19 symptoms with respiratory failure at admission. | 2020-07-18 |
| 32677025 | The testing was accompanied by a questionnaire about symptoms, comorbidities, and contacts. | 2020-07-18 |
| 32677038 | This paper focuses on the impact of the COVID-19 pandemic on clinical care and forensic medical documentation for SGBV survivors, including an analysis of the response in the UK and Kenya, and provides recommendations for safe implementation of these services during the pandemic. | 2020-07-18 |
| 32677384 | To compare the accuracies of quantitative computed tomography (CT) parameters and semiquantitative visual score in evaluating clinical classification of severity of coronavirus disease (COVID-19). […] Demographic data, imaging characteristics, and clinical data were collected, and based on the clinical classification of severity, patients were divided into groups 1 (mild) and 2 (severe/critical). […] Correlation coefficients of the quantitative CT parameters, semiquantitative visual score, and clinical classification were calculated using Spearman’s correlation. | 2020-07-18 |
| 32677385 | The purpose of our study was to investigate the predictive abilities of clinical and computed tomography (CT) features for outcome prediction in patients with coronavirus disease (COVID-19). […] The clinical and CT data of 238 patients with laboratory-confirmed COVID-19 in our two hospitals were retrospectively analyzed. […] A nomogram was constructed based on the combination of clinical and CT features, and its prognostic performance was externally tested in the validation group. […] The predictive value of the combined model was compared with models built on the clinical and radiological attributes alone. […] The combined model provided the best performance over the clinical or radiological model (p < 0.050). […] The prognostic nomogram based on the combination of clinical and CT features could be a useful tool for predicting adverse outcomes of patients with COVID-19. | 2020-07-18 |
| 32677513 | Healthcare workers from three hospitals involved in the care for COVID-19 patients in the united states were invited to share their experience using telemedicine to deliver clinical care to their patients. | 2020-07-18 |
| 32677557 | In this review, we will provide an overview of COVID-19’s clinical features, and discuss the optimization and treatment of spine pathology during the ongoing global pandemic. | 2020-07-18 |
| 32677575 | Loss of income, clinical practice and current surgical management were region-dependent, whereby 50.4% indicated personal-protective-equipment were not adequate. […] 82.3% envisioned a change in their clinical practice as a result of COVID-19. […] More than 33% of clinical practice was via telemedicine. | 2020-07-18 |
| 32677721 | The manifestations of COVID-19 pneumonia in transplant patients are not well understood and may have more severe symptoms, longer duration, and a worse prognosis than in immunocompetent populations. […] This study proposed to evaluate the clinical characteristics of COVID-19 pneumonia in kidney transplant recipients. […] Clinical records, laboratory results, radiological characteristics, and clinical outcome of 24 kidney transplant patients with COVID-19 pneumonia were evaluated from March 20, 2020, to May 20, 2020. | 2020-07-18 |
| 32677733 | Clinical details were recorded. […] A FIT threshold of ≥10 µg Hb/g faeces would be appropriate to triage adult patients presenting to primary care with symptoms of serious colorectal disease. […] FIT may be used to reprioritise patients referred with colorectal cancer symptoms whose investigations have been delayed by the COVID-19 pandemic. | 2020-07-18 |
| 32677734 | Patients require careful monitoring and early referral to hospital if any signs of clinical deterioration occur. […] Clinical evidence is emerging for some specific therapies (including antiviral and immune-modulating agents). | 2020-07-18 |
| 32677752 | This study aimed to assess the association between adipose tissue distribution and severity of clinical course in patients with severe acute respiratory syndrome coronavirus 2. | 2020-07-18 |
| 32677844 | Aim: To describe the association between D-dimer, CRP, IL-6, ferritin, LDH and the clinical outcomes in a cohort of 299 COVID-19 patients treated on the inpatient medical service at a university hospital in the District of Columbia (DC, USA). […] Threshold values for all biomarkers were found to be statistically significant and independently associated with higher odds of clinical deterioration and death. […] Conclusion: Laboratory markers of inflammation and coagulopathy can help clinicians identify patients who are at high risk for clinical deterioration in COVID-19. | 2020-07-18 |
| 32677875 | Out of 308 patients with acute neurological symptoms, 73 patients met the inclusion criteria (23.7%) and were included: 35 ICU patients (47.9%) and 38 non-ICU patients (52.1%). | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] This case reminds clinician that a patient with high clinical suspicion of COVID-19 but multiple negative RT-PCR result should not be taken out of isolation. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677918 | This study analyzed clinical and biochemical parameters between mild and severe patients, helping to identify severe or critical patients early. […] Correlation between the disease criticality and clinical features and peripheral blood biochemical markers was analyzed. | 2020-07-18 |
| 32677926 | The objective of this study was to investigate anxiety symptoms and use of preventive measures against COVID-19. […] The study also compared the association between preventive measures and anxiety symptoms during the week immediately preceding the study and those symptoms and measures at the beginning of the outbreak. […] The 6-item state version of the State-Trait Anxiety Inventory (STAI-6) was used to assess anxiety symptoms. […] Of a total of 3555 completed responses, a total of 52.1% (95% confidence interval [CI] 50.4-53.7) of the respondents reported moderate to severe levels of anxiety symptoms in the past week, whereas 48.8% (95%CI 47.2-50.5) reported moderate to severe anxiety symptoms at the beginning of the outbreak. […] With a higher score indicating greater anxiety, the median scores for anxiety symptoms in the past week and at the beginning of the outbreak were 46.7 (IQR [interquartile range] 36.7-53.3) and 43.3 (IQR 36.7-53.3), respectively. | 2020-07-18 |
| 32678017 | We hope to provide a reference for the research direction of COVID-19 clinical strategies. | 2020-07-18 |
| 32678040 | Demographic, clinical, radiographic, and laboratory measures; treatment; proximate causes of death; and 14-day and 28-day mortality are described. […] The nomogram system based on the four factors revealed good discrimination and calibration, suggesting good clinical utility. | 2020-07-18 |
| 32678060 | Through federal policy changes on telehealth, patient care shifted from in-person to telephone or video visits, and health care providers reached out to patients most at risk for exacerbation of chronic disease symptoms. | 2020-07-18 |
| 32678061 | We propose a stepwise approach to clinical, public health, and policy interventions to reduce COVID-19-associated morbidity and mortality among men. | 2020-07-18 |
| 32678072 | Through sentinel surveillance during March 1-20, DOHMH collected 544 specimens from patients with influenza-like symptoms (ILS)§ who had negative test results for influenza and, in some instances, other respiratory pathogens. | 2020-07-18 |
| 32678431 | The pace of the COVID-19 pandemic makes it timely to take stock of evidence for the involvement of neutrophils and NETs, to weigh the implications, and to increase efficiency in clinical trials. | 2020-07-18 |
| 32678460 | We reviewed 37 published cases of GBS associated with COVID-19 to summarize this information for clinicians and to determine whether a specific clinical or electrodiagnostic (EDx) pattern is emerging. […] The mean time from COVID-19 symptoms to GBS symptoms was 11 days. […] The clinical presentation and severity of these GBS cases was similar to those with non-COVID-19 GBS. […] GBS-associated COVID-19 appears to be an uncommon condition with similar clinical and EDx patterns to GBS before the pandemic. | 2020-07-18 |
| 32678494 | To investigate clinical and radiological features of olfactory clefts of patients with mild coronavirus disease 2019 (COVID-19). […] The epidemiological and clinical data were extracted. […] There were no significant correlations between clinical, radiological, and psychophysical olfactory testing. | 2020-07-18 |
| 32678526 | The Psychiatric Consultation Service at Massachusetts General Hospital sees medical and surgical inpatients with comorbid psychiatric symptoms and conditions. […] During their twice-weekly rounds, Dr Stern and other members of the Consultation Service discuss diagnosis and management of hospitalized patients with complex medical or surgical problems who also demonstrate psychiatric symptoms or conditions. | 2020-07-18 |
| 32678542 | Novel coronavirus SARS-CoV-2 and COVID-19, besides affecting the respiratory system, may lead to central and peripheral nervous system disorders and also cause muscular symptoms. […] The authors review the literature and own clinical case with respect to nervous system involvement in COVID-19 patients. […] Severe neurologic symptoms are primarily observed in patients with severe COVID-19. […] Neurologic-associated symptoms may include stroke, acute necrotizing encephalopathy, and Guillen-Barre syndrome. | 2020-07-18 |
| 32678695 | There is an urgent need to develop vaccines against the virus, and both convalescent plasma and immune globulin are currently in clinical trials for treatment of patients with COVID-19. | 2020-07-18 |
| 32678866 | Baseline covariates included demographics, Early Warning Scores, Charlson Comorbidity Indices and frailty (Clinical Frailty Scale, CFS), linked to COVID-19 status. […] In this study frailty, measured using the Clinical Frailty Scale, appeared to make little incremental contribution to the hazard of dying in older people hospitalised with COVID-19 infection; illness severity and comorbidity had a modest association with the overall adjusted hazard of death, whereas confirmed COVID-19 infection dominated, with a seven-fold hazard for death. | 2020-07-18 |
| 32678882 | It is therefore important to characterize the clinical course and outcome of Covid-19 in this population and identify safe therapeutic strategies. […] Primary outcomes included recovery from symptoms, acute kidney injury, graft failure and case fatality rate. […] Of the 73 patients screened, 54 tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-39 with moderate to severe symptoms requiring hospital admission and 15 with mild symptoms managed in the ambulatory setting. | 2020-07-18 |
| 32678901 | To determine the psychological status and post-traumatic stress symptoms (PTSD) among general population (except confirmed and suspected cases, and close contacts) and their association with the coping strategy types during the COVID-19 outbreak. | 2020-07-18 |
| 32678948 | Raised C-reactive protein at diagnosis predicted an aggressive clinical course. | 2020-07-18 |
| 32678949 | Discrepancies between these guidelines reflect the altruistic wish to protect patients and lack of high-quality evidence available to inform clinical practice. […] These unanswered questions are being studied within the context of clinical trials. | 2020-07-18 |
| 32678961 | Medical records of seven COVID-19 patients treated with VV-ECMO were retrospectively evaluated to determine the clinical outcomes of VV-ECMO. | 2020-07-18 |
| 32679055 | We evaluated the in vitro antiviral activities of a shortlist of compounds, known for their cellular broad-spectrum activities, together with drugs that are currently under evaluation in clinical trials for COVID-19 patients. | 2020-07-18 |
| 32679056 | We conclude that virus infection seems to occur with a similar incidence in men and women among French blood donors, but that blood group O persons are less at risk of being infected and not only of suffering from severe clinical presentations, as previously suggested. | 2020-07-18 |
| 32679081 | Between March 13 and April 24, 2020, we collected clinical data and samples from 5613 patients with COVID-19 from across the East of England. […] These results were fed back to clinical, infection control, and hospital management teams, leading to infection-control interventions and informing patient safety reporting. | 2020-07-18 |
| 32679155 | The aim of this study was to describe the demographic, angiographic, and procedural characteristics alongside clinical outcomes of consecutive cases of COVID-19-positive patients with STEMI compared with COVID-19-negative patients. | 2020-07-18 |
| 32679173 | Here, we explore the dynamics of the response of the scientific community to several epidemics, including Coronavirus Disease 2019 (COVID-19), as assessed by the numbers of clinical trials, publications, and level of research funding over time. | 2020-07-18 |
| 32679205 | Time from symptoms onset to patient arrival at the Emergency Department was longer during the pandemic (44.6 vs. […] Moreso, a longer time from symptoms onset to patient arrival at the Emergency Department was noted. | 2020-07-18 |
| 32679206 | The guiding principles for restarting elective surgeries in a safe and acceptable manner include up-to-date disease awareness, projection and judicious management of equipment and facilities, effective human resource management, a fair and transparent system to prioritize cases, optimization of peri-operative workflows and continuous data gathering and clinical governance. | 2020-07-18 |
| 32679298 | Abbott ARCHITECT SARS-CoV-2 IgG immunoassay was compared to an indirect immunofluorescence assay (IFA) on sera from patients with COVID-19 collected at different days after symptoms onset or infected by other human coronaviruses. […] IgG reactivity against SARSCoV-2 N antigen was detectable in all patients by two weeks after symptoms onset. | 2020-07-18 |
| 32679347 | Patient data was abstracted from medical records at Weill Cornell Medical Center. […] Symptoms of PRES improved with blood pressure control. | 2020-07-18 |
| 32679348 | Navigating the uncertainty of subsequent pandemic waves creates confusion about how to safely reinitiate clinical service. | 2020-07-18 |
| 32679424 | One of the interesting aspects of the clinical manifestation of the infection is an accompanying ocular surface viral infection, viral conjunctivitis. | 2020-07-18 |
| 32679425 | Clinical data show that in addition to respiratory system damage, some male patients with COVID-19 are also accompanied by abnormal renal function and even renal damage. | 2020-07-18 |
| 32679426 | However, in this way, the symptomatic patient experiences all the negative effects of the Th2 response, which can seriously aggravate the clinical picture. | 2020-07-18 |
| 32679435 | Those with more symptoms of depression and anxiety reported greater increases in alcohol consumption (assessed via retrospective timeline follow-back) compared to students with fewer symptoms. | 2020-07-18 |
| 32679582 | Since data regarding the epidemiologic and clinical characteristics in neonates and children developing coronavirus disease 2019 (COVID-19) are scarce and originate mainly from one country (China), we reviewed all the current literature from 1 December 2019 to 7 May 2020 to provide useful information about SARS-CoV2 viral biology, epidemiology, diagnosis, clinical features, treatment, prevention, and hospital organization for clinicians dealing with this selected population. […] IMPACT: Children usually develop a mild form of COVID-19, rarely requiring high-intensity medical treatment in pediatric intensive care unit.Vertical transmission is unlikely, but not completely excluded.Children with confirmed or suspected COVID-19 must be isolated and healthcare workers should wear appropriate protective equipment.Some clinical features (higher incidence of fever, vomiting and diarrhea, and a longer incubation period) are more common in children than in adults, as well as some radiologic aspects (more patchy shadow opacities on CT scan images than ground-glass opacities). | 2020-07-18 |
| 32679589 | Epidemiologic studies of the relationship between vitamin D and various respiratory infections were reviewed and, here, the postulated mechanisms and clinical data supporting the protective role of vitamin D against COVID-19-mediated complications are discussed. | 2020-07-18 |
| 32679784 | Accordingly, a number of clinical trials aiming to determine the efficacy of administration of vitamin D and its metabolites for treatment of these diseases have been conducted with variable outcomes. | 2020-07-19 |
| 32679848 | Additionally, the interviewees indicated that this new modality of health care may be extended to a broader variety of patients and clinical settings. | 2020-07-19 |
| 32679910 | The main object of the study was to investigate the SARS-CoV-2 molecular and serological pattern in patients with mild symptoms including anosmia and ageusia. […] Patients were stratified according to the symptoms’ onset. […] Moreover, the median time from onset of symptoms and enrolment was significantly higher in those patients with negative SARS-CoV-2 RNA in nasal swabs, suggesting that symptoms might last longer than SARS-CoV-2 replication. […] The great majority of patients (80%) developed SARS-CoV-2 IgG at three weeks after symptoms’ onset while the detectability of SARS-CoV-2 RNA dramatically decreased over time, suggesting the crucial role of combination of molecular and serological assays for the diagnosis of COVID-19 in those patients reporting mild symptoms. | 2020-07-19 |
| 32680435 | Significant improvements were reported in communication (P < .0001), clinical assessments (P < .0001), and clinical governance (P < .0001), with positive impact on pediatric decannulation (P = .0008), adult decannulation (P = .04), and quality improvement (P < .0001). […] Barriers included time zones, internet bandwidth, and perceived difficulty of direct clinical translation of highly technical skills. […] While interactive videoconferencing via webinar affords an engaging and scalable strategy for sharing knowledge, further investigation is needed on clinical outcomes to define effective strategies for experiential online learning and virtual in-service simulations. | 2020-07-19 |
| 32680478 | The prevalence of anxiety and depression symptoms were respectively 33.73% (95% CI: 30.53-36.92%) and 29.35% (95% CI: 26.27-32.43%) when a cut-off score of 5 was used for GAD-7 and PHQ-9. […] Risk factors for anxiety symptoms included more time (hours) spent thinking about the COVID-19, and whether or not family members (that is, HCWs) had direct contact with confirmed or suspected COVID-19 patients while high participants’ self-reported safety scores for HCW’s protective equipment was a protective factor. […] More time (hours) spent thinking about COVID-19, longer average working time per week worked by family members (that is, HCWs), and being parents and other next of kin of HCWs were risk factors for depressive symptoms. […] Compared to participants who were HCWs, participants who were private sector workers were more likely to develop depressive symptoms, while government or institutional employees were less likely to suffer from depressive symptoms. | 2020-07-19 |
| 32680592 | To describe clinical features, comorbidity, and prognostic factors associated with in-hospital mortality in a cohort of COVID-19 admitted to a general hospital. | 2020-07-19 |
| 32680602 | Despite the patient presenting with symptoms, namely high fever, severe body pain and severe cough, along with many of the other associated symptoms of COVID-19, the progress of the disease could be arrested within a short period by being exclusively on Ayurvedic medicines. | 2020-07-19 |
| 32680695 | However, there is increasing evidence that other systems are affected by SARS-CoV2; one of which is the gastrointestinal system with several organ-related symptoms and possible implications on prognosis and spread. […] Diarrhoea is one of the main symptoms of gastrointestinal involvement. | 2020-07-19 |
| 32680715 | They had mild forms of COVID-19 and non-specific clinical signs with the exception of agueusia/anosmia, which was significantly more common in those with positive RT-PCR. | 2020-07-19 |
| 32680760 | As the COVID-19 pandemic developed in March 2020 in greater Seattle, our clinical trial site faced several ethical and clinical dilemmas. […] Included are the first 3 weeks of screening by our physicians for potential exposure to COVID-19, common symptoms, temperature, blood oxygen saturation, and heart rate. […] We share how we incorporated COVID-19 Center for Disease Control health recommendations to a clinical trial center and addition of pulse oximetry. | 2020-07-19 |
| 32680828 | There needs to be more effective clinical integration of relevant services, which must be informed by patient choice and clinical need, and accessible throughout the patient’s whole cancer journey. […] Finally, as a clinical community we need to drive a shift in culture towards measurement of patient quality of life as a marker of treatment effectiveness. […] We also need to support our own clinical workforce with their own mental health needs so that we prevent the alarming rates of burnout prevalent among clinicians treating cancer. | 2020-07-19 |
| 32680838 | The NHS in England has rapidly expanded staff testing for COVID-19 in order to allow healthcare workers who would otherwise be isolating with symptoms suspicious of COVID-19 to be cleared to work. | 2020-07-19 |
| 32680880 | We aim to describe the demographics, clinical presentation, hospital course, and severity of pediatric inpatients with coronavirus disease 2019 (COVID-19), with an emphasis on healthy, immunocompromised, and chronically ill children. […] Cases were identified from patients with fever and/or respiratory symptoms who underwent a nucleic acid amplification-based test for severe acute respiratory syndrome coronavirus 2. […] Fever was present in 86% of patients, lower respiratory symptoms or signs in 60%, and gastrointestinal symptoms in 62%. […] The clinical course of immunocompromised patients was not more severe than that of other children. | 2020-07-19 |
| 32680889 | We looked at the issues spanning clinical, ethical and logistics domains; identifying areas of benefit as well as drawbacks, some specific to the rushed implementation because of COVID-19’s infective risks and the ‘rules’ of lockdown, but many are generic areas to help guide longer term service design. | 2020-07-19 |
| 32680914 | Preprint servers, such as arXiv and bioRxiv, have disrupted the scientific communication landscape by providing rapid access to research before peer review. medRxiv was launched as a free online repository for preprints in the medical, clinical, and related health sciences in 2019. | 2020-07-19 |
| 32680942 | To describe neuroimaging findings and to report the epidemiologic and clinical characteristics of patients with coronavirus disease 2019 (COVID-19) with neurologic manifestations. […] Confusion (53%) was the most common neurologic manifestation, followed by impaired consciousness (39%), presence of clinical signs of corticospinal tract involvement (31%), agitation (31%), and headache (16%). […] Patients with COVID-19 may develop a wide range of neurologic symptoms, which can be associated with severe and fatal complications such as ischemic stroke or encephalitis. | 2020-07-19 |
| 32681121 | The infection has rapidly spread out all over the world and Italy has been the first European country experiencing the endemic wave with unexpected clinical severity in comparison with Asian countries. […] These findings suggest that a predisposing genetic background may contribute to the observed interindividual clinical variability associated with COVID-19, allowing an evidence-based risk assessment leading to personalized preventive measures and therapeutic options. | 2020-07-19 |
| 32681141 | Twenty (10.99%) patients out of the 182 were detected to be SARS-CoV-2 RNA positive (re-positives), although none showed any clinical symptomatic recurrence, indicating that COVID-19 responds well to treatment. | 2020-07-19 |
| 32681166 | A subset of coronavirus disease 2019 (COVID-19) patients exhibit clinical features of cytokine storm. […] We studied the reticuloendothelial organs of 4 consecutive patients who died of COVID-19 and correlated with clinical and laboratory parameters to detect HLH. […] Clinical and laboratory results from premortem blood samples were used to calculate H-scores. […] Identification of HLH in a subset of patients with severe COVID-19 will inform clinical trials of therapeutic strategies. | 2020-07-19 |
| 32681280 | However, the two main professional societies for human reproduction (ESHRE and ASRM) appear divergent on their clinical utility and whether they should be adopted. […] In this opinion paper, we review the currently available tests and discuss the strengths and weaknesses of the proposed clinical care pathways. […] Serological assays for SARS-CoV-2 antibodies exhibit a temporal increase in sensitivity and specificity after symptom onset irrespective of the assay used, with sensitivity estimates ranging from 0 to 50% with the first 3 days of symptoms, to 83 to 88% at 10 days, increasing to almost 100% at ≥ 14 days. […] These inherent constraints in diagnostics would suggest that at present there is inadequate evidence to utilize SARS-CoV-2 testing to stratify fertility patients and reliably inform clinical decision-making. | 2020-07-19 |
| 32681308 | We developed a chemiluminescence immunoassay method based on the recombinant nucleocapsid antigen and assessed its performance for the clinical diagnosis of severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infections by detecting SARS-CoV-2-specific IgM and IgG antibodies in patients. […] Plasmas from 29 healthy cohorts, 51 tuberculosis patients, and 79 confirmed SARS-CoV-2 patients were employed to evaluate the chemiluminescence immunoassay method performance for the clinical diagnosis of SARS-CoV-2 infections. […] The developed high sensitivity and specificity chemiluminescence immunoassay IgG testing method combined with the RT-PCR approach can improve the clinical diagnosis for SARS-CoV-2 infections and thus contribute to the control of COVID-19 expansion. | 2020-07-19 |
| 32681385 | Unfortunately, no standard therapies are available in clinical practice; therefore, clinical studies are strongly recommended. | 2020-07-19 |
| 32681398 | This study aims to develop and assess the psychometric properties of a measure of moral injury (MI) symptoms for identifying clinically significant MI in health professionals (HPs), one that might be useful in the current COVID-19 pandemic and beyond. […] Discriminant validity was demonstrated by modest correlations (r’s = 0.25-0.37) with low religiosity, depression, and anxiety symptoms, whereas convergent validity was evident by strong correlations with clinician burnout (r = 0.57) and with another multi-item measure of MI symptoms (r = 0.65). […] ROC characteristics indicated that a score of 36 or higher was 84% sensitive and 93% specific for identifying MI symptoms causing moderate to extreme problems with family, social, and occupational functioning. […] The MISS-HP is a reliable and valid measure of moral injury symptoms in health professionals that can be used in clinical practice to screen for MI and monitor response to treatment, as well as when conducting research that evaluates interventions to treat MI in HPs. | 2020-07-19 |
| 32681447 | They cause two types of clinical manifestations in cattle either an enteric, calf diarrhoea and winter dysentery in adult cattle, or respiratory in all age groups of cattle. […] This paper will cover epidemiology, taxonomy, pathogenesis, clinical signs, diagnosis, therapy, economic impact and prevention of coronavirus infections in cattle. | 2020-07-19 |
| 32681497 | SARS-CoV-2 infection is characterized by a protean clinical picture that can range from asymptomatic patients to life-threatening conditions. | 2020-07-19 |
| 32681526 | Cough and fever were the most common symptoms. […] Compared with older patients, the incidence of fever, respiratory symptoms, lethargy and headache or dizziness was lower, while gastrointestinal symptoms were reported more. […] Atypical symptoms should not be over-emphasized in screening paediatric COVID-19. | 2020-07-19 |
| 32681537 | Despite the urgent clinical need for these therapies, it is imperative to consider potential safety issues. […] This is important due to the harm-benefit ratios that may be encountered when treating COVID-19, which can depend on the stage of the disease, when therapy is administered and underlying clinical factors in individual patients. | 2020-07-19 |
| 32681611 | The objective of this study was to assess the neurological manifestations in a series of consecutive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients, comparing their frequency with a population hospitalized in the same period for flu/respiratory symptoms, finally not related to SARS-CoV-2. […] Patients with flu/respiratory symptoms admitted to Fondazione Policlinico Gemelli hospital from 14 March 2020 to 20 April 2020 were retrospectively enrolled. | 2020-07-19 |
| 32681674 | Although not common, gastrointestinal and liver symptoms have reportedly been the initial presentation of coronavirus disease-2019 (COVID-19) in a large group of patients. […] Original studies providing information on clinical digestive symptoms or biomarkers of liver function in patients with polymerase chain reaction confirmed diagnosis of COVID-19 were included. […] The most common gastrointestinal symptoms were anorexia (10.2%, 95% confidence interval [CI] = 6.2%-16.4%), diarrhea (8.4%, 95% CI = 6.2%-11.2%), and nausea (5.7%, 95% CI = 3.7%-8.6%), respectively. | 2020-07-19 |
| 32681708 | COVID-19 clinical manifestations from donors and recipients, and post-transplant outcomes (COVID-19 infections, readmissions, allograft rejection, and mortality) were obtained. | 2020-07-19 |
| 32681756 | Its clinical and laboratory characteristics and outcome in kidney transplant recipients are little known. | 2020-07-19 |
| 32681783 | In the remaining 203 women, seven referred COVID-19-related symptoms but only one had a positive qRT-PCR. | 2020-07-19 |
| 32681845 | In this review, we introduce the clinical features of coagulation and the increased vascular thrombotic risk conferred by coagulopathy according to present reports about COVID-19. | 2020-07-19 |
| 32681865 | This hypothesis introduces the potential relationship between immune responses to the novel coronavirus and the hastening of preclinical or manifest neurodegenerative disorders. | 2020-07-19 |
| 32681866 | Participants’ demographic data, clinical data and levels of circulating inflammatory markers were collated. […] Mental health symptoms were evaluated with questionnaires, which included the Insomnia Severity Index (ISI) scale, the 9-item Patient Health Questionnaire (PHQ-9), the 7-item Generalized Anxiety Disorder (GAD-7) scale, and questions about patients’ self-perceived illness severity. […] Multivariate linear regression analysis was performed to explore factors that associated with mental symptoms, and a structural equation model (SEM) was used to assess the possible relationships between those factors and the patients’ mental health. […] Among the 85 participants, 45.9% had symptoms of depression (PHQ-9 ≥ 5), 38.8% had anxiety (GAD-7 ≥ 5), and 54.1% had insomnia (ISI ≥ 8). […] Female sex, disease duration, levels of inflammatory markers and self-perceived illness severity are factors that could be used to predict the severity of patients’ mental symptoms. | 2020-07-19 |
| 32681950 | The situation of the COVID-19 pandemic reminds us that we permanently need high-value flexible solutions to urgent clinical needs including simplified diagnostic technologies suitable for use in the field and for delivering targeted therapeutics. […] Park argued that in the last 15 years nanomedicine failed to deliver the promised innovative clinical solutions to the patients (Park, K. […] Furthermore, the >400 nanomedicine formulations currently in clinical trials are expecting to bring novel clinical solutions (e.g. platforms for nucleic acid delivery), alone or in combination with other key enabling technologies to the market, including biotechnologies, microfluidics, advanced materials, biomaterials, smart systems, photonics, robotics, textiles, Big Data and ICT (information & communication technologies) more generally. […] Park that " it is time to examine the sources of difficulty in clinical translation of nanomedicine and move forward “. […] But for reaching this goal, the investments to support clinical translation of promising nanomedicine formulations should increase, not decrease. […] All actions should be taken with a clear clinical view in mind,” without any fanfare“, to focus”on what matters in real life", which is the patient and his/her quality of life. | 2020-07-19 |
| 32681968 | The most common symptoms among COVID-19 infected patients were fever 87% (95% CI 73-93, p < 0.001), and cough 68% (95% CI 55.5-74, p < 0.001)), respectively. […] Fever and cough are the most common symptoms of COVID-19 infection in the literature published to date. | 2020-07-19 |
| 32681983 | Descriptive statistics were used for clinical characteristics and the primary outcome. 11 of 237 (4.6%) hemodialysis patients and 11 of 93 (12%) staff members had a positive RT-PCR test result for SARS-CoV-2. | 2020-07-19 |
| 32681986 | Clinical features, pathology and homology to better understood pathogens suggest that uncontrolled inflammation and a cytokine storm likely drive COVID-19’s unrelenting disease process. […] This article reviews the rationale for exogenous nitric oxide use for the pathogenesis of COVID-19 and highlights its potential for contributing to better clinical outcomes and alleviating the rapidly rising strain on healthcare capacity. | 2020-07-19 |
| 32681989 | To describe the clinical manifestations and outcomes of critically ill children with coronavirus disease-19 (COVID-19) in New York City. […] Fever (72.9%) and cough (71.4%) were the common presenting symptoms. | 2020-07-19 |
| 32682063 | To participate in the study, hospitals were required to meet one of the following criteria: development of a formal plan for a central venous access line team during the pandemic; implementation of a central venous access line team during the pandemic; placement of central venous access by a designated practice group during the pandemic as part of routine clinical practice; or management of an iatrogenic complication related to central venous access in a patient with COVID-19. | 2020-07-19 |
| 32682159 | In total, N = 1005 individuals were included (53% women). 21% scored above the cut off ≥10 points (PHQ-9) for moderate depressive symptoms, 119% scored above the cut-off ≥10 points (GAD-7) for moderate anxiety symptoms, and 16% above the cut-off ≥15 points (ISI) for clinical insomnia. […] Depressive symptoms (21%) and anxiety symptoms (19%) are higher during COVID-19 compared to previous epidemiological data. 16% rated over the cut-off for moderate or severe clinical insomnia. | 2020-07-19 |
| 32682192 | In order to better characterize all patients with these symptoms, a longitudinal national survey was created. | 2020-07-19 |
| 32682217 | However, as widely announced, in Brazil the diagnosis using RT-PCR is still scarce and part of the material collected from COVID-19 patients was disposed of and many patients were not tested, regardless of the seriousness of the symptoms, due to errors of medical data records, improper conservation of the samples after collection and/or during transport, which compromised the quality of the material to be tested. | 2020-07-19 |
| 32682342 | Demographic features, clinical characteristics, and maternal and perinatal outcomes were evaluated. […] Eight of the remaining 71 cases had clinical findings highly suspicious for COVID-19. […] Cough (58.6%) and myalgia (51.7%) were the leading symptoms. […] The clinical course of COVID 19 during pregnancy appears to be mild in the present study. | 2020-07-19 |
| 32682358 | Aim of this study is to evaluate the epidemiological, clinical characteristics and the parameters that determine the clinical course and prognosis of the COVID-19 patients admitted to the Ankara City Hospital during the first month of the pandemic In Turkey. […] Cough and fever were the most common symptoms, while anosmia and loss of taste were observed in 8.6 % and 7.7 % patients, respectively. | 2020-07-20 |
| 32682360 | The time between the onset of symptoms and hospitalization was statistically significantly longer in deceased patients (p=0,039). | 2020-07-20 |
| 32682363 | Knowledge of genomic interindividual variability could help us to explain why different manifestation of clinical severity of Covid-19 infection as well as modified pharmacogenetic relations can be expected during this pandemic condition. | 2020-07-20 |
| 32682444 | This systematic review seeks to answer the following questions in relation to COVID-19: What are the different clinical characteristics presented in maternal and perinatal population? | 2020-07-20 |
| 32682453 | Demographic and clinical data of COVID-19 patients until June 11th, 2020 were retrieved from the State Health Secretariat of Espírito Santo, Brazil. […] The most common symptoms on admission were cough (67.7%) and fever (62.6%); 7.1% of the patients were asymptomatic. | 2020-07-20 |
| 32682454 | Therefore, we should be watchful, searching for early evidence of neurological insults and promoting clinical protocols to investigate them. | 2020-07-20 |
| 32682460 | Thorough and continuous assessment of health and service-use outcomes in mental health clinical practice will be crucial for defining which practices should be further developed and which discontinued. | 2020-07-20 |
| 32682487 | The model also includes tracing of close contacts (eg, household members) and casual contacts, followed by testing regardless of symptoms and isolation if testing positive, with different tracing delays and coverages. | 2020-07-20 |
| 32682491 | Clinical and laboratory data were reviewed. | 2020-07-20 |
| 32682658 | The various clinical manifestations of COVID-19 with RT-PCR positive patients have been reported. […] However, the differences in the clinical presentation between children and adults were unclear. […] Thus, we aimed to investigate the differences in the clinical manifestations and imaging characteristics between Chinese children and adults with COVID-19 by systematically analyzing the data derived from some latest literatures. […] The included papers were analyzed for differences in clinical manifestation between children and adults with COVID-19 after the quality evaluation with the QUADAS-2 tool. […] The differences in the clinical features and CT findings were analyzed using a Pearson χ2 test or Fisher’s exact test. | 2020-07-20 |
| 32682671 | The clinical features and subsequent medical treatment, combined with the impact of a global pandemic, require specific nutritional therapy in hospitalised adults. […] These recommendations were developed using expert consensus, incorporating the documented clinical signs and metabolic processes associated with COVID-19, the literature from other respiratory illnesses, in particular acute respiratory distress syndrome, and published guidelines for medical management of COVID-19 and general nutrition and intensive care. | 2020-07-20 |
| 32682701 | Management of ACS in patients with COVID-19 needs more consideration of the balance between clinical benefit and transmission risk of virus. | 2020-07-20 |
| 32682787 | Many drugs have been screened, and even their clinical trials are going on at an exceptional pace. […] Moreover, many immunomodulatory and viral S protein targeting vaccines have their ongoing clinical trials. […] The establishment of various in vitro and in vivo models for preclinical studies can additionally help the current research. […] The volume and the pace of the clinical trials launched to evaluate the safety and efficacy of various agents against coronavirus disease 2019 (COVID-19) reflect the need for high-quality evidence for various therapies to be practiced by clinicians. | 2020-07-20 |
| 32682788 | Several drugs such as Remdesivir, Hydroxychloroquine, Chloroquine, Ribavirin, Ritonavir, Lopinavir, Favipiravir, Interferons, Bevacizumab, Azithromycin, etc. are currently under clinical trials. […] Vaccine development from various pharmaceutical companies and research institutes is under progress, and more than ten vaccine candidates are in the various phases of clinical trials. […] This review work highlighted the origin, emergence, structural features, pathogenesis, and clinical features of COVID-19. | 2020-07-20 |
| 32682810 | At admission, common symptoms duration had a median of 8 (IQR 5-11) days. | 2020-07-20 |
| 32682993 | Neurologic symptoms were the primary reason for referral for neuroimaging across the studies. | 2020-07-20 |
| 32683039 | The typical symptoms are fever, cough, shortness of breath, evolving to a clinical picture of pneumonia and, ultimately, death. | 2020-07-20 |
| 32683060 | The coronavirus disease 2019 (COVID-19) pandemic has brought most ongoing clinical trials to a standstill, while at the same time emphasizing the need for new therapeutic treatments and strategies to mitigate the morbidity and mortality related to COVID-19. […] Ongoing “stay at home” orders and institutional policies mandating “work from home” for nonessential employees, which includes most research personnel, have impacted the ability to implement and conduct clinical studies. […] This article discusses the approach of an experienced clinical trials unit to make adjustments for ongoing studies and ensure the safety of study participants. […] At the same time, plans were implemented to continue collection of data to achieve endpoints, safely enroll and follow participants in studies offering potential benefit, and quickly implement new COVID-19 clinical trials. […] The existence of a Division of Clinical Research with regulatory, budgeting, contracting, and coordinating expertise within a department of surgery can successfully accommodate a crisis situation and rapidly adapt to new requirements for the safe, efficient, and effective conversion to a remote work force without compromising the research process. | 2020-07-20 |
| 32683185 | Awareness of this clinical entity may facilitate the identification of patients with a potentially remediable cause of encephalopathy in COVID-19. | 2020-07-20 |
| 32683188 | To evaluate the impact of the novel coronavirus pandemic on practice patterns, clinical behavior, personal health, and emotional/psychological concerns of rhinologists. | 2020-07-20 |
| 32683221 | However, further experimental studies and clinical trials should be conducted to evaluate the safety and efficacy of these possible therapies. | 2020-07-20 |
| 32683304 | Possibility of relapse during pandemic was considered as moderate (2.06±1.42), but relapse symptoms would be reported by the majority of subjects (1.55±1.23). | 2020-07-20 |
| 32683320 | De-novo use of statins in people with COVID-19 with no underlying co-morbidity might be beneficial but awaits substantiation in clinical trials; till that time, de novo use of statins in COVID 19 should be limited to a clinical trial setting. | 2020-07-20 |
| 32683333 | In this review, we summarize the current understanding on the pathogenesis, epidemiology, clinical and laboratory features and management of coagulopathy associated with COVID-19. | 2020-07-20 |
| 32683343 | This study aimed to analyze the clinical and epidemiologic characteristics of patients with COVID-19 to better differentiate the suspected patients in Beijing, China. […] Clinical and epidemiologic data were collected from suspected patients with COVID-19 admitted to Beijing Ditan Hospital from January 29 to February 21, 2020. […] There was no significant difference in clinical symptoms or the underlying diseases among the three groups. […] The clinical features of the confirmed patients with COVID-19 were insufficient for early diagnosis of COVID-19. | 2020-07-20 |
| 32683438 | In order to allow patients to recognize symptoms indicative of SARS-CoV-2 infection and self-isolate at the earliest opportunity, self-reported loss of smell and taste have greater value in controlling disease transmis- sion than psychophysical testing, which is not widely available outside of highly specialized clinics. | 2020-07-20 |
| 32683596 | However, a detailed clinical course has not been well described. | 2020-07-20 |
| 32683613 | Further studies are required to confirm if such association remains after accounting for multiple variables, as well as possible relationships with disease severity and worst clinical outcomes. | 2020-07-20 |
| 32683639 | The purpose of our study was to identify differences in the clinical characteristics and the in-hospital mortality of patients with a laboratory-confirmed diagnosis of COVID-19 internationally. […] A comprehensive search of all published literature on adult patients with laboratory-confirmed diagnosis of COVID-19 that reported on the clinical characteristics and in-hospital mortality was performed. […] There is a significant variation in the clinical characteristics in patients diagnosed with COVID-19 across the globe. | 2020-07-20 |
| 32683660 | Patients with diabetes and uncontrolled blood glucose levels are at increased risk for poor clinical outcomes and in-hospital mortality related to COVID-19. | 2020-07-20 |
| 32683744 | The primary objective of the present study was to compare the clinical features and outcomes in hospitalized COVID-19 patients with vs without diabetes. | 2020-07-20 |
| 32683745 | In the light of increased adverse outcomes for people with diabetes affected by COVID-19, we have described the clinical course of a cohort of critically ill patients with COVID-19 and diabetes. | 2020-07-20 |
| 32683753 | COVID-19 is characterized by high infectivity, long incubation period, diverse clinical presentations, and strong transmission intensity. […] The current review summarizes the epidemiological characteristics, potential mechanisms, clinical manifestations, and recent progress in the management of COVID-19 cardiovascular complications. | 2020-07-20 |
| 32683774 | At this early stage, the specific vocabulary used was related to ‘pneumonia symptoms’ and ‘mystery illness’. | 2020-07-20 |
| 32683801 | Children usually present milder symptoms than adults, and management focuses on providing symptomatic and respiratory supports. […] Several treatment modalities, including the utilization of mechanical ventilation (MV), antivirals, immune-modulating drugs, or other agents, may present promising results in reducing the symptoms of COVID-19, particularly in severe cases. […] Although no randomized clinical trials have been published to date, it is interesting to explore potential modalities for treating COVID-19 in children, based on review articles, case reports, and recent guidelines. | 2020-07-21 |
| 32683837 | A scoping review has the objective to review the information available in pregnant women infected with the MERS-CoV, SARSCoV, SARS-CoV-2 coronaviruses to assess the similarities in terms of and differences in the clinical characteristics of the mothers and neonatal outcomes. […] Fever (75.5%) and pneumonia (73.5%) were the most frequent symptoms in infected pregnant women. […] All three coronaviruses produce pneumonia with very similar symptoms, being milder in the case of SARSCoV2. | 2020-07-21 |
| 32683882 | However, more detailed and comprehensive studies including the symptoms of patients are needed. | 2020-07-21 |
| 32683890 | These studies describe a poorly understood spectrum of COVID-19 central nervous system symptoms, ranging from common and subclinical issues such as anosmia and headache to more concerning reports of stroke and encephalopathy. | 2020-07-21 |
| 32683962 | The chief of surgery of a 264-bed acute care facility and clinic system in Topeka, KS, USA, gives a chronology that illustrates the rapid and profound clinical, economic, and emotional impact of the SARS-CoV-2 outbreak on his hospital and community. | 2020-07-21 |
| 32684101 | In this retrospective and multi-center study, 373 patients with laboratory-confirmed COVID-19 from Shanghai Public Health Clinical Center and Affiliated Hospital of Putian University were recruited. […] Demographic, clinical, radiological features, and laboratory data were recorded and analyzed at admission and at discharge. | 2020-07-21 |
| 32684114 | The present study highlights the potentiality of DB02388 and Cobicistat as anti-COVID-19 drugs for clinical trials. | 2020-07-21 |
| 32684122 | In this review, we summarise the current knowledge on the epidemiology, pathophysiology, genetics, clinical diagnosis, risk stratification and treatment of patients with BrS, with special emphasis on COVID-19 comorbidity. | 2020-07-21 |
| 32684145 | Median time from onset of COVID symptoms to stroke diagnosis was 21 days. | 2020-07-21 |
| 32684205 | In the clinical treatment of COVID-19, the theoretical system of “three syndromes and three methods” for treating critical diseases based on syndrome differentiation by integrated traditional Chinese medicine (TCM) and Western medicine has been recognized by the majority of clinical respiratory and critical disease experts. […] In order to facilitate the clinical practitioners better understanding the “three syndromes and three methods”, and apply the theory into the treatment of COVID-19, Expert opinion on diagnosis and treatment of coronavirus disease 2019 with traditional Chinese medicine based on “three syndromes and three methods” was organized by experts from China Association of Integrative Medicine Emergency Medicine Committee, which could make references for clinical practice. | 2020-07-21 |
| 32684206 | The main contents include the possible mechanism of CP, the evidence of CP in the treatment of COVID-19 patients, the safety of clinical application of CP and the main factors affecting the clinical effect of CP, which may provide some basis for clinicians to choose CP for the treatment of adult patients with COVID-19. | 2020-07-21 |
| 32684210 | The Chinese keyword co-occurrence, clustering and highlighted words analysis showed that the main research areas of severe COVID-19 included clinical features, traditional Chinese medicine treatment, medical imaging, integrated traditional Chinese and Western medicine treatment and so on; nucleic acid detection, clinical features and diagnosis, plague theory and etiology mechanism, traditional Chinese medicine and integrated Chinese and Western medicine treatment, severe COVID-19 combined with diabetes and prognosis research will become future research trends; keyword cluster analysis showed that severe COVID-19, combined chronic underlying diseases, CT imaging characteristics will also become new trends in the field of research. | 2020-07-21 |
| 32684340 | Clinical applicability of rapid diagnostic test kit for SARS-CoV-2 antibodies was evaluated. | 2020-07-21 |
| 32684351 | Up to now, there are over 1000 clinical studies for COVID-19 all over the world. […] Meanwhile, we systematically reviewed their clinical safety, clinical applications and progress of antiviral researches. […] The therapeutic effect of these antiviral drugs is summarized and compared, hoping to provide some ideas for clinical options of COVID-19 treatment and also provide experiences for the life-threatening virus diseases in the future. | 2020-07-21 |
| 32684483 | A scoping review of registered clinical trials using cell-based interventions for COVID-19 was conducted to identify candidate studies for meta-analysis that could support an accelerated regulatory review. […] ClinicalTrials.gov and WHO International Clinical Trials Registry Platform were searched April 23, 2020. | 2020-07-21 |
| 32684497 | The studies showed that virus-like nanoparticles (VLPs) could be effective in its goal of stopping the symptoms of MERS-CoV infection. | 2020-07-21 |
| 32684645 | The mean severity of current symptoms, assessed by patients on a visual-analogue scale, was 4.9 ±2.4. 82% of the respondents selected telephone consultations as the most convenient form of receiving rheumatology advice. | 2020-07-21 |
| 32684717 | All the medical staff members have worn the PPE and no one have developed COVID symptoms. | 2020-07-21 |
| 32684754 | Similar to adults, the primary symptoms at presentation include fever, cough, sore throat, malaise, nasal discharge, and rarely, vomiting and diarrhea in children. […] Although the majority of pediatric patients are asymptomatic or have a mild clinical course, severe cases have been reported in children with underlying chronic diseases. | 2020-07-21 |
| 32684814 | Some of these lecturers are clinicians who need to juggle between clinical work and teaching, and consider a two-week adaptation during this period to be not enough. […] Furthermore, converting traditional face-to-face learning to online formats for undergraduate and postgraduate clinical programmes would reduce the learning outcomes, especially those related to clinical applications and the acquisition of new skills. | 2020-07-21 |
| 32685022 | Several drugs have demonstrated in vitro activity against SARS-CoV-2 or potential clinical benefits. | 2020-07-21 |
| 32685076 | We report a case of acute myelitis in a 32-year old male COVID-19 positive patient who presented with a 2-day history of flu-like symptoms then sudden onset paraplegia and urinary retention. […] Nevertheless considering the broad differential diagnosis of acute myelitis, prompt clinical, and diagnostic work up was crucial to exclude other causes. […] Patients presenting with neurological symptoms such as loss of consciousness, ataxia, convulsions, status epilepticus, encephalitis, myelitis or neuritis should raise concerns for COVID-19 infection during this pandemic prompting early diagnosis and initiation of proper management. | 2020-07-21 |
| 32685080 | The clinical manifestations, laboratory examination, and chest CT characteristics of 3 patients with COVID-19 pneumonia were reported. […] The mainly clinical manifestation of the 3 patients was fever. | 2020-07-21 |
| 32685081 | Infection with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, also known as COVID-19) may remain asymptomatic in the initial phase, leading to under-recognition and incidental detection on procedures for standard clinical indications. […] Hospitals, in particular diagnostic imaging services, should prepare accordingly in regard to health precautions while keeping in mind the potential discrepancies between clinical presentation and resultant radiologic patterns. | 2020-07-21 |
| 32685124 | Lastly, there is no consensus as to whether everyone should be tested for COVID-19 and not based on presence of clinical features. | 2020-07-21 |
| 32685167 | A typical clinical manifestation of COVID-19 is pneumonia, which can progress to acute respiratory distress syndrome and respiratory failure. | 2020-07-21 |
| 32685170 | Many medical symptoms of COVID-19 were reported. | 2020-07-21 |
| 32685173 | However, no clinical studies on the impact of the COVID-19 pandemic on emergency medical service (EMS) systems have been carried out. | 2020-07-21 |
| 32685221 | We present the case series of four patients (2 men and 2 women; 1 Caucasian and 3 African Americans; two survived and two died) with confirmed COVID-19, presenting with respiratory symptoms and acute kidney injury, who have been on angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. | 2020-07-21 |
| 32685234 | PubMed, Google Scholar, Science Direct, Directory of open access journals (DOAJ) and reference lists were searched to identify articles associated with antiviral and other properties of N.sativa related to the signs and symptoms of COVID-19. […] Various randomized controlled trials, pilot studies, case reports and in vitro and in vivo studies confirmed that N.sativa has antiviral, antioxidant, anti-inflammatory, immunomodulatory, bronchodilatory, antihistaminic, antitussive activities related to causative oraganism and signs and symptoms of COVID-19. | 2020-07-21 |
| 32685262 | The purpose of telemedicine, using telecommunications technology, must be to optimize the clinical management of heart failure patients at home, in order to improve their quality of life, reducing hospitalization and emergency department access, also promoting self-management. | 2020-07-21 |
| 32685300 | Currently, there is no effective treatment available and the data are evolving through continuous clinical trials and ongoing research. […] We report two cases of COVID-19 patients who initially presented with moderate to severe symptoms. […] Later, their clinical course worsened despite ongoing treatment with multiple medications such as hydroxychloroquine and azithromycin until they were started on tocilizumab. | 2020-07-21 |
| 32685302 | We report the case of a polymerase chain reaction (PCR)-confirmed COVID-19 in a Hispanic male with no past medical history who presented to the ED with upper respiratory tract symptoms including shortness of breath and cough, requiring continuous positive airway pressure (CPAP) therapy. | 2020-07-21 |
| 32685307 | This article reports two cases of fulminant myocarditis in COVID-19 positive patients who presented to our facility with contrasting symptoms, laboratory and imaging findings. | 2020-07-21 |
| 32685313 | This case highlights the extensive resources needed for critically ill patients with COVID-19 and the long duration that patients may test positive for the virus after onset of symptoms. | 2020-07-21 |
| 32685326 | The symptoms started to resolve on pharmacological treatment and supplemental noninvasive oxygen supply over the next weeks. | 2020-07-21 |
| 32685369 | In addition, we present other COVID-19 related transplant cases reported in the literature outlining the presenting clinical signs and outcomes. | 2020-07-21 |
| 32685374 | The present study investigated an 18-days-old neonate who was referred to the hospital with suspected respiratory symptoms of COVID-19. | 2020-07-21 |
| 32685386 | Third, protective measurements tools in the center to detect and prevent any exposure of the patients to patients and to protect medical staff, COVID-19 scoring system was set up to identify patients with fever, respiratory symptoms, acute conjunctivitis or recent travel to outbreak areas and to encourage these individuals to postpone their appointments for at least 21d. | 2020-07-21 |
| 32685412 | Overall, 21 articles were reviewed, and clinical characteristics of 90 pregnant patients and 92 neonates born to mothers infected with COVID-19 were reviewed. […] The most common symptoms included fever, cough, and dyspnea. […] Nineteen patients reported having no symptoms, while breathing problems and pneumonia were reported as the most common neonatal complications. […] There were no differences in the clinical characteristics of pregnant women and non-pregnant COVID-19 patients. | 2020-07-21 |
| 32685484 | The identification of viral pathogenic mechanisms is important for further developing effective drugs and targeted clinical treatment methods. | 2020-07-21 |
| 32685628 | Between 21st January and 20th March 2020, 244 children who were confirmed to have COVID-19 infection and admitted to the Wuhan Children’s Hospital, China were retrospectively reviewed. 193 children were considered as symptomatic, which was defined as having either the presence of clinical symptoms or the presence of CT thorax abnormalities. | 2020-07-21 |
| 32685697 | For COVID-19, infections in the absence of apparent symptoms have been reported frequently alongside circumstantial evidence for asymptomatic or pre-symptomatic transmission. | 2020-07-21 |
| 32685882 | The clinical spectrum of coronavirus disease 2019 (COVID-19) is wide, ranging from minor, nonspecific symptoms to severe pneumonia, acute respiratory distress syndrome, multiorgan involvement, and shock. | 2020-07-21 |
| 32685886 | Therefore, aberrant expression of TF may be the underlying basis of COVID-19 symptoms. […] Evidence suggests a correlation between infection with many virus types and development of clotting-related symptoms, ranging from heart disease to bleeding, depending on the virus. | 2020-07-21 |
| 32685905 | Early reports of coronavirus disease 2019 (COVID-19) clinical features describe a hypercoagulable state, and recent guidelines recommend prophylactic anticoagulation for patients with COVID-19 with low-molecular-weight heparin, but this would be contraindicated in the presence of heparin-induced thrombocytopenia (HIT). […] We address the key clinical question whether HIT is also present during COVID-19. | 2020-07-21 |
| 32686094 | To explore the health beliefs of clinical and academic nurses from Japan, Australia and China regarding wearing paper masks to protect themselves and others, and to identify differences in participants’ health beliefs regarding masks. | 2020-07-21 |
| 32686164 | To evaluate the incidence of certain symptoms in a population of health workers exposed to COVID-19 patients. […] This study analyzed the incidence of COVID-19 symptoms in both patient groups. […] The presence of symptoms such as hyposmia hypogeusia, dysthermia and cough were strongly associated with a positive RT-PCR. […] The 85.4% of these patients recovered olfactory function within the first 14 days of the onset of the symptoms. | 2020-07-21 |
| 32686219 | In preclinical models, senolytics delay, prevent or alleviate frailty, cancers and cardiovascular, neuropsychiatric, liver, kidney, musculoskeletal, lung, eye, haematological, metabolic and skin disorders as well as complications of organ transplantation, radiation and cancer treatment. […] As anticipated for agents targeting the fundamental ageing mechanisms that are ‘root cause’ contributors to multiple disorders, potential uses of senolytics are protean, potentially alleviating over 40 conditions in preclinical studies, opening a new route for treating age-related dysfunction and diseases. […] Clinical trials for diabetes, idiopathic pulmonary fibrosis, Alzheimer’s disease, COVID-19, osteoarthritis, osteoporosis, eye diseases and bone marrow transplant and childhood cancer survivors are underway or beginning. […] Until such studies are done, it is too early for senolytics to be used outside of clinical trials. | 2020-07-21 |
| 32686245 | Considering that the current literature has provided no conclusive evidence that biologics increase the risk of COVID-19, withdrawal of these agents should be reserved for patients with COVID-19 symptoms. | 2020-07-21 |
| 32686260 | Data from the large randomized trials support the conclusion that CQ and HCQ do not provide any clinical improvements in disease severity and progression of SARS-CoV-2 patients, as well as they do not present any solid evidence of increased serious side effects. […] These drugs are safe and effective antimalarials agents, but in SARS-CoV-2 patients, they need further studies in the context of clinical trials. | 2020-07-21 |
| 32686287 | Most of the 86 children and adolescents with diabetes and COVID-19 had only mild/moderate symptoms, while 5 required admission to an intensive care unit. | 2020-07-21 |
| 32686331 | Obesity may serve as a clinical predictor for adverse outcomes; therefore, the inclusion of BMI in prognostic scores and improvement of guidelines for the intensive care of patients with elevated BMI are highly recommended. | 2020-07-21 |
| 32686556 | The coronavirus disease 2019 (COVID-19) pandemic has significantly impacted the health-care system both in Australia and internationally, and has rapidly transformed the delivery of health care in hospitals and the community. […] Health care in the post-pandemic period should embed the use of telehealth for outpatient care and consider the range of other clinical contexts where this can be utilised. | 2020-07-21 |
| 32686566 | This may cause increased psychosomatic symptoms in persons with pre-existing mental illnesses, and additionally raises new challenges for the general population. […] The materials presented at our webpage www.cope-corona.de aim to easily reach citizens affected by symptoms such as worries, depression or anger and let them receive readily understandable expert knowledge and training in basic self-help methods. | 2020-07-21 |
| 32686633 | Drugs are generally well tolerated in clinical practice; however, both can cause corrected QT prolongation. […] The data including demographics, clinical symptoms, co-morbid diseases, laboratory, radiological findings as well as electrocardiographs of the patients were obtained from our records. | 2020-07-21 |
| 32686774 | This paper reviews currently available data on the novel coronavirus and clinical features of COVID-19, followed by a detailed section on possible modifications of immunomodulatory therapy in multiple sclerosis patients with COVID-19, based on what we know so far. […] There are discussed: (i) The COVID-19 disease (Epidemiological background SARS-CoV-1 coronavirus; Autoimmune response to COVID-19; Asymptomatic course; SARS-CoV-2 test; COVID-19 symptoms), (ii) Treatment of COVID-19 (Experimental plasma treatment; Antiviral therapy; Antimalarial treatment scheme; Biological treatment; Corticosteroid treatment; Symptomatic treatment; Vaccine preparation) and (iii) Multiple sclerosis and SARS-CoV-2 infection (Epidemiological recommendation). | 2020-07-21 |
| 32686780 | Several important gender differences in susceptibility, clinical manifestation and response to treatments for a number of diseases are known since a long time, although they continue to be underestimated by a multiplicity of operators, especially men. […] A gender-based approach to clinical practice also in the context of this pandemic seems to be mandatory, as it could significantly contribute to health promotion by improving the effectiveness of diagnostic and/or therapeutic approaches and, therefore, leading to important benefits primarily for the patients but also for the sustainability of the National Health System. | 2020-07-21 |
| 32686781 | SARS-CoV-2 is manifesting as a multi-dimensional disease and, recently, unique co-existing pathophysiological and clinical aspects are being defined: (i) an increased immune and inflammatory response with the activation of a cytokine storm and consequent coagulopathy, which promote both venous thromboembolic events and in situ thrombosis localized in small arterioles and pulmonary alveolar capillaries; (ii) a high intrapulmonary shunt, which often accounts for the severity of respiratory failure, due to reduced hypoxic pulmonary vasoconstriction with pulmonary neo-angiogenetic phenomena. […] The aim of this position paper from the Italian Association of Hospital Cardiologists (ANMCO) is to highlight the main implications that COVID-19 infection has on the pulmonary circulation from a pathophysiological, clinical and management point of view. | 2020-07-21 |
| 32686784 | We describe the clinical course of an unusual presentation with isolated reversible high degree atrioventricular block in a patient with COVID-19. | 2020-07-21 |
| 32686937 | The rapid publication of information, both regarding the clinical course and the viral biology, has yielded incredible knowledge of the virus. | 2020-07-21 |
| 32686943 | Clinical trials related to BCG vaccination against COVID-19 are under investigation. | 2020-07-21 |
| 32686955 | Aim: Evaluation of a novel microsampling device for its use in clinical sample collection and biomarker analysis. […] Statistically significant correlation in selected ELISA assays also confirmed the TAP device applicability to the quantitative analysis of protein biomarkers in clinical trials. | 2020-07-21 |
| 32687061 | The consultation topics mainly included respiratory symptoms such as cough, expectoration, and fever (2489/4120, 60.4%) and disease knowledge, anxiety, and fear (1023/4120, 24.8%). […] After the consultation, the participants’ knowledge of the symptoms, transmission routes, and preventive measures of COVID-19 was significantly higher than before the consultation (t3058=-106.105, -80.456, and -152.605, respectively; all P<.001> | 2020-07-21 | </.001>
| 32687112 | The disease is associated with typical and atypical signs and symptoms, mimicking other common illnesses. | 2020-07-21 |
| 32687145 | Our aim was to provide an objective, informative summary of 1) the mounting diet-related health burdens facing our nation and corresponding economic, health equity, national security, and sustainability implications; 2) the current federal nutrition research landscape and existing mechanisms for its coordination; 3) the opportunities for and potential impact of new fundamental, clinical, public health, food and agricultural, and translational scientific discoveries; and 4) the various options for further strengthening and coordinating federal nutrition research, including corresponding advantages, disadvantages, and potential executive and legislative considerations. | 2020-07-21 |
| 32687152 | Informatics-trained physicians and nurses drew upon their trusted relationships with multiple teams within the organization to create practical solutions for onboarding, clinical decision-making, telehealth, and predictive analytics. | 2020-07-21 |
| 32687172 | The American Proficiency Institute sent 2 test samples to 346 clinical laboratories in order to assess the accuracy of SARS-CoV-2 assays. […] Overall performance in this SARS-CoV-2 RNA detection challenge was excellent, providing confidence in the results of these new molecular tests and assurance for the clinical and public health decisions based on these test results. | 2020-07-21 |
| 32687223 | A univariable analysis indicated that clinical classification, lymphocyte count, and interleukin-2 receptor were associated with a lengthened negative time of nucleic acid, with a significant difference between two groups (P = .036). […] Our study provided additional evidence of no obvious difference in progress and prognosis between ACEIs/ACEIs and CCBs group, which may suggest ACEIs/ARBs may have scarcely influence on increasing the clinical severe situations of COVID-19 patients with hypertension. | 2020-07-21 |
| 32687241 | The key theme across all jurisdictions was to not compromise clinical judgement and to enable individualized, ethical and patient-centred care. | 2020-07-21 |
| 32687630 | To date, these medications are not approved for the treatment of viral infections, and there are no well-controlled, prospective, randomized clinical studies or evidence to support their use in patients with coronavirus disease 2019 (COVID-19). […] This work provides basic clinical pharmacology information relevant for planning and initiating COVID-19 clinical studies with chloroquine or hydroxychloroquine, summarizes safety data from healthy volunteer studies, and summarizes safety data from phase II and phase II/III clinical studies in patients with uncomplicated malaria, including a phase II/III study in pediatric patients following administration of azithromycin and chloroquine in combination. […] In addition, this work presents data describing the proposed mechanisms of action against the severe acute respiratory distress syndrome coronavirus-2 and summarizes clinical efficacy to date. | 2020-07-21 |
| 32687645 | To assess clinical outcomes and adverse drug events in patients hospitalised with COVID-19 treated with off-label hydroxychloroquine (HCQ) and azithromycin (Az). […] The primary end point was clinical improvement on day 7 defined as either hospital discharge or an improvement of 2 points on a 6-category ordinal scale. […] Clinical improvement was seen in 26.8% of patients who received HCQ/Az but this was not significant. […] Although patients who received HCQ/Az were more severely ill the administration of these repurposed drugs did not result in clinical improvement and was associated with a significant increase in toxicity. | 2020-07-21 |
| 32687677 | Some challenges and dilemmas currently faced during the pandemic include the management of cancer patients during the treatment and follow-up phases, the assessment of the safety of treatments currently used for the management of SARS-CoV-2 for use in cancer patients, the development of psychoeducation and emotional support for cancer patients and the safe conduct of clinical trials involving participation of cancer patients. | 2020-07-21 |
| 32687696 | The repurposing of drugs that are approved or are under advanced clinical investigation provides a cost- and time-effective therapeutic solution. […] This review summarizes the major repurposed approaches that have been proposed or are already being studied in clinical trials for COVID-19. | 2020-07-21 |
| 32687823 | No health care workers who participated in ECMO cannulation developed symptoms of or tested positive for COVID-19. | 2020-07-21 |
| 32687870 | Our findings suggest that further work in this area (or translation to a clinical setting) should use a cumulative UV-C dose of 40,000 J/m2 or greater, and confirm appropriate mask fit following decontamination. | 2020-07-21 |
| 32687917 | Nonetheless, few broad-spectrum antiviral drugs, azithromycin were tested against COVID-19 in clinical trials, and finally, FDA approved emergency use of remdesivir in hospitalized COVID-19 patients. […] Finally, a short and brief clinical update has been provided concerning the development of therapeutic medications and vaccines to counter COVID-19. | 2020-07-21 |
| 32687997 | Clinical and epidemiological studies are needed to present robust evidence that SARS-CoV-2 is transmissible via aerosols, though quantification of virus-laden aerosols at low concentrations presents a challenge. […] Wastewater surveillance of SARS-CoV-2 can be an effective tool in early detection of outbreak and determination of COVID-19 prevalence within a population, complementing clinical testing and providing decision makers guidance on restricting or relaxing movement. | 2020-07-21 |
| 32688022 | Of them, 23.6% reported moderate or severe psychological impact of the outbreak, 28.3%,24%, and 22.3% reported moderate to severe depressive, anxiety, and stress symptoms, respectively. […] Experiencing breathing difficulty and dizziness showed a stronger association with higher IES-R and DASS subscales than other somatic symptoms (e.g., headache and fever);(p < .001). […] Respondents who practiced specific preventative measures (e.g., hand washing, social distancing) demonstrated a protective effect against stress, anxiety, and depression symptoms. | 2020-07-21 |
| 32688039 | Three residents demonstrated COVID-19 symptoms (no hospitalizations occurred) for a total 24 workdays lost (median 7 workdays). | 2020-07-21 |
| 32688068 | After 3 weeks, participants were interviewed for the presence of COVID-19-compatible clinical symptoms and signs, including in household members, and offered immediate testing for SARS-CoV-2 RNA if indicated. | 2020-07-21 |
| 32688107 | The aims of this study were to analyze the clinical characteristics of older adult patients with COVID-19. | 2020-07-21 |
| 32688185 | The neoteric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been jeopardizing the world with the symptoms of seasonal flu. | 2020-07-21 |
| 32688346 | To investigate the clinical, laboratory, and radiological characteristics of patients with coronavirus disease-2019 (COVID-19) in Heilongjiang Province. […] Significant differences were observed in clinical symptoms, laboratory tests, and computed tomography features between the ICU and non-ICU groups. | 2020-07-21 |
| 32688420 | This is the first study to investigate mental health, i. e. adjustment disorder, depression, stress symptoms, Corona related fears as well as coping mechanisms in this group in a German-speaking country. […] A series of standardized assessments were included: adjustment disorder (ADNM-20), depression (PHQ-9), stress symptoms and coping strategies (SCI). | 2020-07-21 |
| 32689590 | Identify clinical and radiographic features of venous infarct as a presenting feature of COVID-19 in the young. […] Although elderly patients with comorbidities are considered highest risk for COVID-19 neurologic complications, usually when systemic symptoms are severe, this case report emphasizes that young individuals are at risk for VTE with neurologic complications even when systemic symptoms are mild, likely induced by COVID-19 associated hypercoagulable state. | 2020-07-22 |
| 32689621 | The observations at our tertiary care center corroborate anecdotal reports that the number of new stroke diagnoses is falling, which seems related to a smaller proportion of patients seeking healthcare services for milder symptoms. | 2020-07-22 |
| 32689643 | The aim of this review is to provide insights into the clinical manifestations and pathophysiological mechanisms of stroke in COVID-19 patients. | 2020-07-22 |
| 32689650 | Anecdotal evidence and clinical observation suggest that there is a decrease in the number of patients presenting with stroke during the pandemic. | 2020-07-22 |
| 32689813 | Therefore, it is important to strengthen the warning and monitoring of severe patients, and early identify the severe and critically severe types in time in the clinical treatment of COVID-19. | 2020-07-22 |
| 32689815 | It has become necessary to adapt our clinical practice to the current COVID-19 pandemic and physical distancing regulations. | 2020-07-22 |
| 32689846 | Comparisons with other members of the coronavirus family responsible for severe acute respiratory syndrome (SARS) have been done to predict maternal and neonatal outcomes; however, more information is required to establish clinical patterns, disease evolution and pregnancy prognosis in this group of patients. […] We have analyzed the demographic characteristics, pregnancy-related conditions and presenting symptoms to identify features that could determine which patients will need hospitalization because of COVID-19 (Group 1-G1) and those who not (Group 2-G2). | 2020-07-22 |
| 32689925 | The most common symptoms identified amongst HCWs were fever (85%), cough (70%), and weakness (70%). | 2020-07-22 |
| 32689937 | Data derived from the experience of multiple centers around the world have demonstrated that initial clinical efforts should be focused into avoid intubation and mechanical ventilation in hypoxemic COVID-19 patients. […] On the other hand, COVID-19 patients progressing or presenting into frank ARDS with typical decreased pulmonary compliance, represents another clinical enigma to many clinicians, since routine therapeutic interventions for ARDS are still a subject of debate. | 2020-07-22 |
| 32690074 | To assess the efficacy of local intranasal treatment with budesonide (nasal irrigation), in addition to olfactory rehabilitation, in the management of loss of smell in COVID-19 patients without signs of severity and with persistent hyposmia 30 days after the onset of symptoms. […] Inclusion criteria - Patient over 18 years of age; - Patient with a suspected SARS-CoV-2 infection, whether or not confirmed by PCR, or close contact with a PCR-confirmed case, typical chest CT scan (unsystematic frosted glass patches with predominantly sub-pleural appearance, and at a later stage, alveolar condensation without excavation or nodules or masses) or positive serology ; - Patient with isolated sudden onset hyposmia persisting 30 days after the onset of symptoms of CoV-2 SARS infection; - Affiliate or beneficiary of a social security scheme; - Written consent to participate in the study. […] Non-inclusion criteria - Known hypersensitivity to budesonide or any of the excipients; - Hemostasis disorder or epistaxis; - Oral-nasal and ophthalmic herpes virus infection; - Long-term corticosteroid treatment; - Treatment with potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, voriconazole, posaconazole, clarithromycin, telithromycin, nefazodone and HIV protease inhibitors); - Severe forms of SARS-CoV-2 with respiratory or other signs; - Hyposmia persisting for more than 90 days after the onset of symptoms - Other causes of hyposmia found on interrogation or MRI; - Patient benefiting from a legal protection measure; - Pregnant or breastfeeding women. | 2020-07-22 |
| 32690096 | The main symptoms of COVID-19 are fever, cough, myalgia, fatigue and lower respiratory tract infection signs. […] This review is intended to summarize the research on this new coronavirus, to analyze the similarities and differences between COVID-19 and previous outbreaks of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) and to provide guidance regarding new methods of prevention, diagnosis and clinical treatment based on autodock simulations. […] We also found that the types and severity of clinical symptoms vary, which means that the diagnosis and nursing measures also require differentiation. […] Their receptors and routes of transmission are not all the same, which makes them different in clinical features and treatments. | 2020-07-22 |
| 32690231 | From the perspective of the clinical manifestation, autopsy examination and pathophysiology, the essence of COVID-19 should be viewed as a sepsis induced by viral infection, and has the essential characteristics as sepsis induced by other pathogens. | 2020-07-22 |
| 32690299 | Engineering controls used plastic sheeting to segregate and treat patients who developed symptoms while airborne. | 2020-07-22 |
| 32690307 | Because of the pulmonary involvement, clinical manifestations, use of inhaled fluticasone, and need for longer and accurate follow-up and to protect against coronavirus disease 2019, he has been temporarily suspended until the final assignment. | 2020-07-22 |
| 32690324 | The doctor of the Nasrid Kingdom of Granada, Ibn Jatima from Almeria, wrote Treatise on the Plague, in which it may be found epidemiological and clinical similarities between both plagues. […] Due to its similitude, it would be the first antecedent of the MOF physiopathological concept, a finding that enriches the scientific and historical heritage of our clinical specialty. | 2020-07-22 |
| 32690352 | To describe the clinical characteristics and predictors of major outcomes in patients treated with tocilizumab (TCZ) for severe COVID-19 pneumonia. […] Clinical outcomes: death, length of hospital stay. […] An early clinical response to TCZ (48-72 h after the administration) was assessed by variations in respiratory function markers, Brescia COVID Respiratory Severity Scale (BCRSS), inflammatory parameters, and patients’ and physicians’ opinion. | 2020-07-22 |
| 32690356 | However, laboratory and animal model testing are crucial to minimize the potential risk for patients when treated with a device that may worsen clinical outcome if poorly designed or misused. | 2020-07-22 |
| 32690444 | This study describes the early clinical characteristics of COVID-19 in patients with more than 80 years of age. […] Epidemiological, clinical, laboratory, radiological, and treatment data from 17 patients diagnosed with COVID-19 between January 20 and February 20, 2020 were collected and analyzed retrospectively. […] Treatment outcomes among subgroups of patients with non-severe and severe symptoms of COVID-19 were compared. […] The most common symptoms at the onset of COVID-19 were fever (n = 13; 76.5%), fatigue (n = 11; 64.7%), and cough (n = 5; 29.4%). […] The mortality of patients aged 80 years and older with severe COVID-19 symptoms was high. […] However, the majority of patients with COVID-19 in this age cohort had atypical symptoms, and early diagnosis depends on prompt use of a viral nucleic acid test. | 2020-07-22 |
| 32690631 | Adaptations in diabetes care in the hospital (ie, changes in treatment protocols according to clinical status, diabetes technology implementation) and outpatient setting (telemedicine, mail delivery, patient education, risk stratification, monitoring) have been improvised to address this challenge. | 2020-07-22 |
| 32690910 | Clinical studies have also reported an association between COVID-19 and cardiovascular disease. […] In this Review, we summarize the current understanding of COVID-19 from basic mechanisms to clinical perspectives, focusing on the interaction between COVID-19 and the cardiovascular system. […] By combining our knowledge of the biological features of the virus with clinical findings, we can improve our understanding of the potential mechanisms underlying COVID-19, paving the way towards the development of preventative and therapeutic solutions. | 2020-07-22 |
| 32690986 | The patient was urgently contacted and denied any current symptoms but reported suffering mild upper respiratory tract symptoms two weeks earlier. | 2020-07-22 |
| 32690987 | We report a case of presumed rhabdomyolysis in a 38-year-old male with COVID-19 based on the clinical presentation, laboratory results and radiological findings. | 2020-07-22 |
| 32690998 | Furthermore, in the setting of the COVID-19 pandemic, similar clinical and radiographic presentations between COVID-19 and EVALI can be seen. | 2020-07-22 |
| 32690999 | English and Chinese language databases will be searched for primary studies of viral respiratory tract infections and clinical trial registries for SARS-CoV-2 infections. | 2020-07-22 |
| 32691000 | We found 9 guidelines that provide herbal formula for medical observation based on clinical manifestation. | 2020-07-22 |
| 32691002 | We analyzed the symptoms of SARS-CoV-2, a classification of the Chinese medicine dialectic and treatment regimen, and promptly enacted the recommendation of Korean medicine preparations in herbal medicine covered under domestic medical insurance benefits depending on the circumstances in our country. […] The clinical practice guideline (CPG) for the treatment of SARS-CoV-2 was developed based on consensus from a group of experts. | 2020-07-22 |
| 32691004 | Gastrointestinal symptoms and mild abdominal pain are common. | 2020-07-22 |
| 32691006 | This review describes the etiology and signs and symptoms as well as the current allopathic therapy for COVID-19. | 2020-07-22 |
| 32691007 | Controversial data found improved oxygenation after treatment with tocilizumab, an interleukin-6 inhibitor, sparking a wave of interest and resultant clinical trials evaluating immunomodulatory therapies. | 2020-07-22 |
| 32691014 | Masks are thought to have two modes of effect: they prevent infection with COVID-19 in wearers; and prevent transmission by individuals with subclinical infection. | 2020-07-22 |
| 32691016 | The predictions of these models illustrate (1) why ambitious lock-down interventions to crush the curve represent the only realistic way for individual countries to contain their national-level epidemics before they turn into outright catastrophes, (2) why these need to be implemented so early, so stringently and for such extended periods, (3) why high prevalence of other pathogens causing similar symptoms to mild COVID-19 precludes the use of contact tracing as a substitute for lock down interventions to contain and eliminate epidemics, (4) why partial containment strategies intended to merely flatten the curve, by maintaining epidemics at manageably low levels, are grossly unrealistic, and (5) why local elimination may only be sustained after lock down ends if imported cases are comprehensively excluded, so international co-operation to conditionally re-open trade and travel between countries certified as free of COVID-19 represents the best strategy for motivating progress towards pandemic eradication at global level. | 2020-07-22 |
| 32691024 | COVID-19 is caused by SARS-CoV-2, and common clinical symptoms include fever, cough, sore throat, headache, and fatigue. […] In this review we summarize the most up to date literature around the association between COVID-19 and myocarditis and provide clinicians a practical framework about the clinical manifestations, diagnostic tools, and treatment options currently available. […] Importantly, this review will heighten suspicion for myocarditis as an etiology of myocardial injury in COVID-19 patients, therefore improving clinical outcomes and encouraging shared clinical decision-making. […] Emergent treatment options for COVID-19 are in clinical trials and might be of benefit to COVID-19 patients with myocarditis in addition to current guideline-based recommendations. | 2020-07-22 |
| 32691131 | This incidentally leads to the unexpected but not at all negative finding that a consistent clinical improvement had been occurred in most (82.3%) of children. […] Clinical evaluation performed in 27.4% cases revealed normal middle ear findings in all but three (89.3%) children.Conclusion: Our data document a global improvement of otitis-prone children in Milan during the Italian lockdown, as a fortuitous and incidental positive effect of the national lockdown. […] What is New: • Most of children reached by means of a telemedicine assessment during lockdown experienced a subjective clinical improvement; clinical assessment at the end of the lockdown revealed normal otoscopic findings in most cases. […] • Exceptional circumstances during COVID-19 pandemic had a fortuitous positive effect on otitis-prone children’s clinical conditions. | 2020-07-22 |
| 32691135 | Symptoms of depression, unspecific anxiety and COVID-19 related anxiety were ascertained with standardized questionnaires. […] Frequency, duration and diversity of media exposure were positively associated with more symptoms of depression and unspecific and COVID-19 specific anxiety. […] We obtained the critical threshold of seven times per day and 2.5 h of media exposure to mark the difference between mild and moderate symptoms of (un)specific anxiety and depression. | 2020-07-22 |
| 32691211 | Patient characteristics, demographics, symptoms, vital signs, laboratory tests, and chest CT results (CO-RADS) were collected. | 2020-07-22 |
| 32691236 | To study the frequency of neurological symptoms and complications in COVID-19 patients in a systematic review of the literature. […] Headache, dizziness, taste and smell dysfunctions, and impaired consciousness were the most frequently described neurological symptoms, the latter more often among patients with a severe or critical disease course. […] The most frequent neurological symptoms reported in association with COVID-19 are non-specific for the infection with SARS-CoV-2. […] Standardized international registries are needed to clarify the clinical relevance of the neuropathogenicity of SARS-CoV-2 and to elucidate a possible impact of SARS-CoV-2 infection on common neurological disease, such as Alzheimer’s, Parkinson’s disease or multiple sclerosis. | 2020-07-22 |
| 32691334 | However, no proven effective therapies currently exist, and different clinical phenotypes complicate the situation. […] In clinical practice, many severe or critically ill COVID-19 patients developed gastrointestinal (GI) disturbances, including vomiting, diarrhoea, or abdominal pain, even in the absence of cough and dyspnea. […] Understanding the mechanism of GI disturbances is warranted for exploring better clinical care for COVID-19 patients. […] With evidence collected from clinical studies on COVID-19 and basic research on a rare genetic disease (i.e., Hartnup disorder), we put forward a novel hypothesis to elaborate an effective nutritional therapy. | 2020-07-22 |
| 32691604 | These algorithms provided a delineated set of guidelines to triage patients in need of palliative services and included provisions for acute symptoms management and the protection of both the patient care team and the families of patients with COVID-19. | 2020-07-22 |
| 32691641 | This study aimed to present the prevalence of overall and asymptomatic SARS-CoV-2 infection rates in pregnant women admitted to the hospital, and assess the diagnostic accuracy of maternal symptoms and lung ultrasound (LUS) findings in detecting the infection. […] On a secondary diagnostic performance analysis, the positive predictive value and the sensitivity were found as 44% and 47.8% for the triage based on maternal symptoms and, 82.3% and 60.9% for the triage based on LUS, respectively. | 2020-07-22 |
| 32691697 | Generic antiviral drug remdesivir has been found to reduce time to clinical recovery but with insignificant clinical benefits and the antimalarial drug, hydroxychloroquine has been red flagged by USFDA for use as a prophylactic measure due to its cardiotoxicity. […] There is an acute requirement for a drug candidate that has significant clinical benefit with minimal to no side effects. | 2020-07-22 |
| 32691699 | It is important to accurately analyze the available evidence to provide correct clinical guidance for optimal patient care. […] We aim to discuss current clinical evidence regarding chloroquine, hydroxychloroquine, azithromycin, remdesivir, and the cardiovascular burden of COVID-19. […] Additional clinical trials were identified through the “TrialsTracker” project. […] There is no convincing clinical evidence of chloroquine, hydroxychloroquine with or without azithromycin, and remdesivir use in COVID-19. […] As evidence of systemic inflammation is rapidly unfolding, there is a dire need to maximize our resources to find the best possible solutions to the current crisis while conclusive evidence from clinical trials emerges. | 2020-07-22 |
| 32691730 | We describe the clinical characteristics, radiological findings, and treatment of the hemodialysis patient, including the patient’s initial pneumonia at presentation with progression to acute respiratory distress syndrome (ARDS). | 2020-07-22 |
| 32691881 | Ten included studies contain the number of presymptomatic patients, who were asymptomatic at screening point and developed symptoms during follow-up. […] Nearly half of the patients with no symptoms at detection time will develop symptoms later. | 2020-07-22 |
| 32691919 | The nucleic acid test (NAT) of COVID-19 currently was the most reliable established laboratory diagnosis method in clinical. […] The confirmed patients in isolation hotels, hospital ward and fever clinical were mainly middle-aged and elderly, and most of them were women. | 2020-07-22 |
| 32691999 | Workers were screened if they had symptoms or were traced as contacts. […] A total of 736 workers (52 in the ED) had symptoms, and 151 had positive test results (9 from the ED). | 2020-07-22 |
| 32692000 | To describe the clinical characteristics of patients with coronavirus disease 2019 (COVID-19) treated in hospital emergency departments (EDs) in Spain, and to assess associations between characteristics and outcomes. […] Demographic and baseline health information, including concomitant conditions; clinical characteristics related to the ED visit and complementary test results; and treatments were recorded throughout the episode in the ED. […] The logistic regression models were constructed with 3 groups of independent variables: the demographic and baseline health characteristics, clinical characteristics and complementary test results related to the ED episode, and treatments. […] Clinical variables directly associated with worse outcomes were impaired consciousness and pulmonary crackles; headache was inversely associated with worse outcomes. […] This profile of the clinical characteristics and comorbidity of patients with COVID-19 treated in EDs helps us predict outcomes and identify cases at risk of exacerbation. | 2020-07-22 |
| 32692001 | The primary objective was to describe the clinical characteristics and 30-day mortality rates in emergency department patients with coronavirus disease 2019 (COVID-19) in different diagnostic groupings. […] We collected clinical, radiologic, and microbiologic data related to the emergency visit. […] Secondary outcomes were hospitalization and clinical severity of the episode. […] Short-term outcomes differed significantly in the different groups according to demographic characteristics; comorbidity and clinical, radiographic, analytical, and therapeutic variables. […] COVID-19 diagnostic groups differ according to clinical and laboratory characteristics, and the differences are associated with the 30-day prognosis. | 2020-07-22 |
| 32692002 | To analyze clinical, laboratory, and radiologic findings and final health outcomes in patients with pulmonary embolism and coronavirus disease 2019 (COVID-19). […] Clinical, laboratory, and radiologic findings; medical histories and comorbidity; risk factors; and outcomes were compared between the 2 groups of patients (with or without COVID-19). […] We found no between-group differences in clinical presentation, laboratory, or radiologic findings; nor were there differences in final outcomes. […] We found no clinically important differences in the clinical, laboratory, or radiologic findings between patients with or without COVID-19 who were treated for pulmonary embolism in our hospital EDs. | 2020-07-22 |
| 32692176 | To address and counterbalance unwanted effects of elastase-related proteases, chemical inhibitors of CatC are being evaluated in preclinical and clinical trials. | 2020-07-22 |
| 32692208 | Little is known about the clinical characteristics of patients with SARS-CoV-2 infection in the high-altitude region of China. […] We reported the clinical characteristics of patients with coronavirus disease 2019 (COVID-19) in Gansu province, China. […] The information on the epidemiological, clinical characteristics, laboratory tests, radiological features on admission, treatment and outcome were obtained with the final follow-up of March 13, 2020. […] Common symptoms included fever (41, 47.7%), and cough (37, 43.0%). | 2020-07-22 |
| 32692228 | However, a technical standard for oxygen therapy nursing, as well as how this would improve clinical outcomes and symptoms, is yet to be explored. […] Baseline characteristics, symptoms, and finger pulse oxygen saturation were collected during hospitalization. […] Clinical outcomes of the 30 patients were as follows: 27 patients (90.00%) were cured and discharged; 3 patients (10.00%) who continued to stay in hospital were stabilized with symptoms relieved. […] The symptoms of dyspnea, fatigue, and muscle aches of the patients were improved when transferred out of ICU, compared with their condition when admitted to ICU (P<0.05). […] It not only improves the clinical outcomes of critical patients but also effectively reduces the infection risk of medical staff while emphasizing nursing quality management. | 2020-07-22 |
| 32692238 | This case highlighted the importance of close coordination between Chinese medicine and western medicine in the diagnosis and treatment, as well as the need for rapid dissemination of clinical information related to patient care with this emerging infection. […] We reported a COVID-19 case confirmed in China and described the identification, diagnosis, clinical course, and management of the case. […] The patient had initial mild symptoms at presentation; it progressed to severe pneumonia on the 10th day of onset. | 2020-07-22 |
| 32692241 | To analyze the clinical and infectious characteristics of new coronavirus pneumonia with diagnosed and suspected cases in the Second Hospital of WISCO(Wuhan Iron and Steel Company) of Qingshan District, Wuhan City, and further enhance the understanding of new coronavirus pneumonia. […] The proportion of fever and other clinical symptoms was 81.8%, 65.5% of the patients had the fastest heart rate of 90-120 rpm, and 11 of the patients had severe/critical illness, accounting for 20%. | 2020-07-22 |
| 32692266 | The present communication is aimed at highlighting the efforts that are currently underway to treat or prevent SARS-CoV-2 infection, with details on the science, clinical status, and timeline for selected investigational drugs and vaccines. […] This article is going to be of immense help to the scientific community and researchers as it brings forth all the necessary clinical information of the most-talked-about therapeutics against SARS-CoV-2. […] All the details pertaining to the clinical status of each therapeutic candidate have been updated as of June 12, 2020. | 2020-07-22 |
| 32692346 | We combined weekly nasal swab collection with self-reports of respiratory symptoms from 191 participants to investigate the profile of recurring infections with endemic coronaviruses. | 2020-07-22 |
| 32692365 | The serum was collected from March 23 through May 12, 2020, for routine clinical testing by 2 commercial laboratory companies. | 2020-07-22 |
| 32692408 | The corresponding clinical findings and neonatal outcomes also were recorded. | 2020-07-22 |
| 32692464 | Several recent studies have reported an abnormal liver chemistry profile among patients with coronavirus disease 2019 (COVID-19), although its clinical significance remains unknown. […] Further prospective studies are crucial to understand the pathophysiologic mechanisms underlying the hepatic manifestations of the novel COVID-19 infection and its clinical significance. | 2020-07-22 |
| 32692465 | In addition to pneumonia, other COVID-19-associated symptoms have been reported, including loss of smell (anosmia). | 2020-07-22 |
| 32692580 | Repurposing existing drugs is a particularly attractive approach as pharmacokinetic and safety data already exist; thus, development can leapfrog straight to clinical trials of efficacy, generating results far more quickly than de novo drug development. | 2020-07-22 |
| 32692649 | The measures implemented had to do mostly with scientific preparation and team reorganization; management of personal protective equipment; redesigning the department’s clinical common areas, separation of patient circuits with creation of a designated COVID Operating Room, Post-Anesthetic Care Unit; rescheduling of elective surgery and testing all patients before anesthesia procedures and consulting other hospital departments. […] In this period, 64 cases with COVID-19 or with high clinical suspicion were approached. | 2020-07-22 |
| 32692666 | In sum, the COVID-19 mRT-LAMP-LFB assay is a promising tool for diagnosing SARS-CoV-2 infections in frontline public health field and clinical laboratories, especially from resource-poor regions. | 2020-07-22 |
| 32692706 | COVID-19 pandemic is changing profoundly the obstetrics and gynecology (OB/GYN) academic clinical learning environment in many different ways. | 2020-07-22 |
| 32692708 | Guidelines for auditing, evaluation, and clinical care in perinatal medicine enable physicians diagnose, treat and follow-up of COVID-19-exposed pregnant women. | 2020-07-22 |
| 32692733 | CASE REPORT A 53-year old patient was admitted with symptoms and diagnostic findings consistent with AIP. […] Thorough etiological workup revealed an elevated IgG4 level of 361 mg/dL and significant clinical response to corticosteroid treatment, leading to a diagnosis of AIP. […] After significant clinical improvement, the patient was discharged to quarantine at home, which he completed uneventfully. | 2020-07-22 |
| 32692736 | The model was parameterized using current best estimates of key epidemiological parameters from COVID-19 clinical studies. | 2020-07-22 |
| 32692815 | The majority of the children with SARS-CoV-2 infection present with respiratory symptoms, hence various chest imaging modalities have been used in the management. […] CT scan is the most frequently used imaging modality for COVID-19 in children and can detect pneumonia before the appearance of clinical symptoms. | 2020-07-22 |
| 32692874 | Major bleedings (MB) and clinically relevant non-major bleeding (CRNMB) were obtained from patient medical records and were adjudicated by an independent committee. | 2020-07-22 |
| 32692877 | Although there is a clear association with elevated D-dimer and severity of COVID-19 disease, it is important to highlight the fact that D-dimer has always been utilised in conjunction with clinical pre-test probability, as a predictive tool to help exclude a possible diagnosis of venous thromboembolism. […] It has never been validated to guide clinical treatment or anticoagulation. | 2020-07-22 |
| 32692894 | Consolidated reports regarding the clinical and laboratory findings in COVID-19 patients reveal thrombocytopenia, elevated D-dimer, prolonged prothrombin time, disseminated intravascular coagulation, and pulmonary intravascular coagulation (PIC). | 2020-07-22 |
| 32692945 | Rationale: Many clinical studies have focused on the epidemiological and clinical characteristics of inpatients with coronavirus disease (COVID-19). […] However, there are few reports about the clinical follow-up of discharged patients.Objectives: To describe the follow-up of patients with COVID-19 in Wenzhou City, Zhejiang, China.Methods: We retrospectively reviewed 4-week follow-ups in patients with COVID-19, including computed tomographic (CT) chest scanning, blood testing, and oropharyngeal-swab testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ribonucleic acid. […] All the CT and clinical data were collected between January 23 and March 28, 2020. […] Nucleic-acid test results became recurrently positive in 17.6% of discharged patients, of whom only 33.3% complained of clinical symptoms. | 2020-07-22 |
| 32693089 | Genetic factors such as the HLA type of patients may play a role in regard to disease severity and clinical outcome of patients with COVID-19. […] MHC 4-digit typing along with viral sequence analysis should be considered in studies examining clinical outcomes in patients with COVID-19. | 2020-07-22 |
| 32693241 | In this review we discuss the potential impact of IL-6 and NLRP3 inflammasome blocker drugs on inflammatory responses, viral clearance, and pathological and clinical manifestations. […] Collectively, anti-inflammatory strategy might pave the way to diminish clinical and pathological manifestations and thereby discharging patients infected with COVID-19 from hospital. | 2020-07-22 |
| 32693646 | These data are consistent with routine clinical observations and suggest the importance of pharmacovigilance. | 2020-07-23 |
| 32693650 | Tocilizumab, an inhibitor of the interleukin-6 receptor, may decrease the inflammatory response and control the symptoms of severe coronavirus disease 2019 (COVID-19), but the evidence is scarce. […] We assessed on-treatment changes in clinical status and inflammatory markers. […] Clinical status improved within 24 hours in 11 (39%) patients, within one week in 23 (82%) patients, and within two weeks in 25 (89%); one (4%) patient showed no change and two (7%) patients died. […] Tocilizumab can control the symptoms of severe COVID-19 by reducing the inflammatory response and rapidly improves the clinical status in most patients. | 2020-07-23 |
| 32693652 | To date, clinical evidence suggests lack of benefit from HCQ use for the treatment of hospitalized patients with COVID-19. | 2020-07-23 |
| 32693665 | There are no clinical data yet suggesting that any available candidate vaccine will be effective for COVID-19 which will be a critical need for eventually preventing this disease. […] The clinical evaluations of COVID-19 vaccines need to follow standardized protocols that are essential for safeguarding humans. | 2020-07-23 |
| 32693756 | Therefore, there is an urgent need to find new therapeutics that can be progressed to clinical development as soon as possible. […] Repurposing regulatory agencyapproved drugs and experimental drugs with known safety profiles can provide important repositories of compounds that can be fast-tracked to clinical development. […] Globally, over 500 clinical trials involving repurposed drugs have been registered, and over 150 have been initiated, including some backed by the World Health Organisation (WHO). […] This review is intended as a guide to research into small-molecule therapies to treat COVID-19; it discusses the SARS-CoV-2 infection cycle and identifies promising viral therapeutic targets, reports on a number of promising pre-approved small-molecule drugs with reference to over 150 clinical trials worldwide, and offers a perspective on the future of the field. | 2020-07-23 |
| 32693757 | We also observed that no specific vaccine treatments is available for treatment of 2019-nCov, however, developing novel chemical or biological drugs and kits for early diagnosis, prevention and disease management is the primarily governing topic among the patented inventions. […] This multifaceted analysis of identified patent literature provides an understanding of the focuses on present ongoing research and grey area in terms of the trends of technological innovations in disease management in patients with CoV and 2019-nCoV. | 2020-07-23 |
| 32693960 | Spontaneous pneumomediastinum (SPM) and Loculated pneumothorax (LPNX) are both generally rare clinical and radiological conditions associated with Coronavirus Disease 2019 (COVID-19). […] We report for the first time clinical data and radiological chest CT imaging of two patients affected by COVID-pneumonia associated with early radiological findings of SPM and LPNX. | 2020-07-23 |
| 32694043 | One hundred eighty-nine COVID-19 positive patients including 115 patients in plasma therapy group and 74 patients in control group, registered in the hospitals with confirmed COVID-19 infection, entered this multi-center clinical study. […] This clinical study provides strong evidence to support the efficacy of convalescent plasma therapy in COVID-19 patients and recommends this treatment for management of these patients. […] Clinical efficacy, immediate availability and potential cost effectiveness could be considered as main advantages of convalescent plasma therapy. | 2020-07-23 |
| 32694083 | In addition, 4 cases who were all negative for nucleic acid test detection with no clinical symptoms, and none of their chest CT were abnormal. | 2020-07-23 |
| 32694127 | Due to its fundamental role in the induction, training, and function of the immune system, it is critical to include characterizations of the gut microbiome in clinical trials and studies that aim to broaden our understanding of coronavirus disease 2019 (COVID-19). | 2020-07-23 |
| 32694130 | Wastewater surveillance represents a complementary approach to clinical surveillance to measure the presence and prevalence of emerging infectious diseases like the novel coronavirus SARS-CoV-2. […] SARS-CoV-2 is shed in stool early in the clinical course and infects a large asymptomatic population, making it an ideal target for wastewater-based monitoring. […] Our results suggest that the number of positive cases estimated from wastewater viral titers is orders of magnitude greater than the number of confirmed clinical cases and therefore may significantly impact efforts to understand the case fatality rate and progression of disease. | 2020-07-23 |
| 32694169 | Clinical observations have also highlighted that these patients have elevated von Willebrand factor (vWF) and factor VIIIc. 24 consecutive COVID-19 positive patients were selected from the intensive care unit (ICU) or the high acuity ward of Brighton and Sussex University Hospitals NHS Trust. | 2020-07-23 |
| 32694221 | The objectives were to evaluate the effectiveness of conducting three versus two reverse transcription-PCR (RT-PCR) tests for diagnosing and discharging people with COVID-19 with regard to public health and clinical impacts by incorporating asymptomatic and presymptomatic infection and to compare the medical costs associated with the two strategies. | 2020-07-23 |
| 32694244 | The authors describe the clinical course of a patient with SARS-COV-2-19 interstitial pneumonia treated with the combination of an anti-interleukin 6 (IL-6) agent (tocilizumab) and hemoadsorption (HA). | 2020-07-23 |
| 32694267 | Clinical and surgical ophthalmology volume abruptly decreased in March 2020 as a result of the COVID-19 public health crisis. | 2020-07-23 |
| 32694271 | We aim to provide an evidence-based approach to optimize the use of slit lamp shields during clinical examination. | 2020-07-23 |
| 32694291 | To characterize the clinical pharmacists’ impact on caring for patients with inflammatory bowel disease during COVID-19. […] A clinical pharmacist’s encounters between March 17 and April 14, 2020, were audited to determine encounter frequency and indication. […] The clinical pharmacist addressed COVID-19 and inflammatory bowel disease treatment concerns with 140 patients, conducted 34 medication education and monitoring visits, reviewed 141 patients’ charts and helped rescheduled 18 patients who missed their biologic infusion, transitioned 12 patients to home infusions, and assisted 5 patients with medication access. […] Clinical pharmacists embedded in gastroenterology practices permit for continued optimal patient care during a pandemic. | 2020-07-23 |
| 32694498 | While many patients experience mild to moderate symptoms, severely affected patients often progress to acute respiratory distress syndrome (ARDS). […] His initial presenting symptoms included sore throat, headache, fever, and diarrhea. […] The patient’s clinical picture, which was unstable on presentation, further deteriorated to involve significant desaturations, generalized seizure activity, and cardiac arrest requiring resuscitation. […] In the face of an unfavorable clinical picture, the family opted for comfort care measures. | 2020-07-23 |
| 32694793 | For infectious-disease outbreaks, clinical solutions typically focus on efficient pathogen destruction. | 2020-07-23 |
| 32695122 | Coronavirus disease-19 (COVID-19) describes a set of symptoms that develop following infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] In this review, we discuss the most recent findings in terms of clinical features and the host immune response, and suggest candidate immune pathways that may be compromised in otherwise healthy individuals with fulminating COVID-19. | 2020-07-23 |
| 32695170 | This paper strives to provide a brief overview of the etiology, incubation, symptoms, and transmission paradigms of this novel infection and how to minimize the spread in a dental healthcare setting. | 2020-07-23 |
| 32695319 | Peritoneal dialysis (PD) remains available and has been used in clinical practice for AKI for >70 years; however, it has been used on only a limited basis and therefore experience and knowledge of its use has gradually vanished, leaving a considerable gap. | 2020-07-23 |
| 32695322 | Five were diagnosed by reverse transcription polymerase chain reaction (RT-PCR) because of compatible symptoms, while two were diagnosed by RT-PCR as a result of screening 197 HD patients without respiratory symptoms by chest CT. […] Chest CT may identify COVID-19 patients without clear symptoms, but the specificity is low. | 2020-07-23 |
| 32695323 | We conducted an observational single-centre cohort study to describe clinical characteristics, treatments and outcomes of dialysis patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. […] We tested patients who presented symptoms or had contact with a confirmed case. | 2020-07-23 |
| 32695326 | The incidence, severity, clinical presentation, biological characterization (transient versus persistent AKI; proteinuria, haematuria and glycosuria) and short-term outcomes were evaluated. | 2020-07-23 |
| 32695327 | Our objective was to determine whether Fanconi syndrome is a frequent clinical feature in coronavirus disease 2019 (COVID-19) patients. | 2020-07-23 |
| 32695328 | So far, little is known about the course of the disease and its symptoms, complications and treatment. | 2020-07-23 |
| 32695427 | Drug repositioning is the scientific strategy of investigating existing drugs for additional clinical indications. […] Clinical research groups recognizing efficacy of these “old” drugs for a new indications often face an uphill struggle due to a lack of funding and support because of poor structural and regulatory support for clinical drug development. […] A new regulatory framework is needed to prevent abuse of the legislation and promote clinical investigator-driven drug repositioning. | 2020-07-23 |
| 32695551 | Coronavirus disease 2019 (COVID-19) is a novel infectious viral disease, which lacks well-established diagnostic laboratory parameters that could be used to evaluate disease severity, thromboembolism or cardiovascular events and to predict clinical prognosis. | 2020-07-23 |
| 32695683 | While the majority of infected subjects are asymptomatic or show mild symptoms, there is an important proportion of patients who requires hospitalization and, sometimes, intensive care. […] Analysis of the reported results from clinical trials clearly show an involvement of specific cellular immunity (predominantly leucopenia, decreased counts of CD3+, CD4+, and CD8+ T lymphocytes, changes of T cell compartment) and the so-called cytokine storm, which is associated with worsening of symptoms and the promotion of lung damage. […] Examination of selected immune parameters could help to identify severe patients with the risk of unfavorable course of the disease, predict the prognosis and recognize improvement in the clinical status. | 2020-07-23 |
| 32695719 | However, randomized controlled trials are the need of the hour to conclusively determine its clinical efficacy in such infections. | 2020-07-23 |
| 32695791 | Background: The unprecedented impact of the COVID-19 pandemic on modern society has ignited a “gold rush” for effective treatment and diagnostic strategies, with a significant diversion of economic, scientific, and human resources toward dedicated clinical research. […] We call for the harmonization of clinical trial design criteria for COVID-19 and the increased use of larger master protocols incorporating elements of adaptive designs. […] COVID Trial Monitor identifies critical issues in current COVID-19-related clinical research and represents a useful resource with which researchers and policymakers can improve the quality and efficiency of related trials. | 2020-07-23 |
| 32695804 | The pathophysiological changes identified cytokine storm mechanism for out setting the series of adverse clinical conditions. […] Currently these aren’t approved for preventing or treating COVID-19 cases, however clinical trials are afoot to dispense the utmost understanding in terms of efficacy and safety concerns. | 2020-07-23 |
| 32695885 | There is substantial interest in using presenting symptoms to prioritize testing for COVID-19 and establish symptom-based surveillance. […] However, little is currently known about the specificity of COVID-19 symptoms. […] To assess the feasibility of symptom-based screening for COVID-19, we used data from tests for common respiratory viruses and SARS-CoV-2 in our health system to measure the ability to correctly classify virus test results based on presenting symptoms. | 2020-07-23 |
| 32696002 | Uncertainty regarding coronavirus disease 2019 clinical course, shifts in attitude, and changes in routine behavior have hindered Bundle use. | 2020-07-23 |
| 32696003 | Clinical observation of a patient. […] Clinical observation and data extraction from electronic medical records. | 2020-07-23 |
| 32696004 | Taking into consideration the multisystemic clinical and autopsy findings in “severe” coronavirus disease 2019 patients, viral sepsis would be a more accurate term to describe the whole clinical picture. | 2020-07-23 |
| 32696006 | To compare the clinical outcome of mechanically ventilated patients with severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome, who received corticosteroid with those who did not. | 2020-07-23 |
| 32696008 | Our positive experience with tocilizumab in combination with methylprednisolone started early after endotracheal intubation may be one avenue for reducing the morbidity and mortality seen with severe coronavirus disease 2019 and merits further exploration in clinical studies. | 2020-07-23 |
| 32696035 | If we are to both take advantage of the largest natural experiment of our lifetimes, and provide evidence to inform the numerous public health and clinical decisions being made every day, we must act quickly to ask critical questions and develop new methods to answer them. | 2020-07-23 |
| 32696088 | Grade of urgency of electroencephalography (EEG) may vary according to the clinical indication, setting, and status of infection of SARS-CoV-2 virus. […] “Italian Society of Clinical Neurophysiology” (SINC), “Italian League Against Epilepsy” (LICE), and the “Italian Association of Neurophysiology Technologists” (AITN) aimed to provide clinical and technical recommendation for EEG indications and recording standards in this pandemic era. […] Presidents of SINC, LICE, and AITN endorsed three members per each society to formulate recommendations: classification of the degree of urgency of EEG clinical indications, management and behavior of physicians and neurophysiology technologists, hygiene and personal protection standards, and use of technical equipment. […] Scientific societies endorsed a paper conveying the recommendation for EEG execution in accordance with clinical urgency, setting (inpatients/outpatients), status of SARS-CoV-2 virus infection (positive, negative and uncertain), and phase of governmental restrictions (phase 1 and 2). […] Briefly, in phase 1, EEG was recommended only for those acute/subacute neurological symptoms where EEG is necessary for diagnosis, prognosis, or therapy. | 2020-07-23 |
| 32696108 | The cytokine storm and viral evasion of cellular immune responses may play an equally important role in the pathogenesis, clinical manifestation, and outcomes of COVID-19. […] In this review, we discuss the potential role and safety of these agents in the management of severe COVID-19, and their impact on survival and clinical symptoms. | 2020-07-23 |
| 32696116 | The type and frequency of these findings were recorded and correlated with clinical information including age, gender, and symptoms. | 2020-07-23 |
| 32696234 | Many of the drugs that are currently in (pre)clinical development are addressing late symptoms of the disease. […] Several agents have potential for prophylactic and therapeutic intervention at the early stages of SARS-CoV-2 infection and COVID-19 disease and they should be urgently investigated further in appropriate preclinical models and clinical studies. | 2020-07-23 |
| 32696241 | Twenty one full-term pregnant patients who were admitted to the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, confirmed SARS-CoV-2 infection and COVID-2019 with laboratorial and clinical methods, were reviewed by our medical team, and the data were collected from January 20, 2020 to February 29, 2020. […] Clinical data had been collecting using a standard case report form, such as epidemiological history, clinical manifestations, auxiliary examination of major laboratory and clinic, etc. […] According to our review, all the cases were infected by human to human transmission, and the most common symptoms at onset of illness were cough in 17 (80.95%), fatigue in 10 (47.62%), fever in 7 (33.33%), expectoration in 1 (4.76%), and only one patient (4.76%) developed shortness of breath on admission. […] The median time from exposure to onset of illness was 10 days (interquartile range 7 -2 days), and from onset of symptoms to first hospital admission was 1 day (interquartile range 1-2 days). | 2020-07-23 |
| 32696333 | Clinical data, delay for surgery, mechanism of injury and injury pattern were also reviewed. | 2020-07-23 |
| 32696334 | Orthopaedic trainees’ demographic data (six questions), clinical role changes (four questions), institutional changes due to the COVID-19 pandemic (nine questions), and personal considerations (five questions) were examined. […] Most trainees retained their customary clinical role (59.8%), but a significant number was redeployed to COVID-19 units (20.9%). […] Most trainees felt the decrease in clinical, surgical, and educational activities would have a detrimental effect on their training. | 2020-07-23 |
| 32696341 | Intriguing evidences showed that COVID-19 infection can modify clinical spectrum of manifested neurological disorders but also it plays a crucial role in the development of future diseases as long-tem consequences. | 2020-07-23 |
| 32696396 | However, there are limited data from clinical studies to prove the application of DHODH inhibitors in Coronavirus disease 2019 (COVID-19) patients. | 2020-07-23 |
| 32696426 | In view of the existing clinical evidence for the innocuousness and efficiency of systemic administration of DSCs or AECs in similar conditions, we advocate for the initiation of clinical trials using this strategy in the treatment of severe COVID-19 disease. | 2020-07-23 |
| 32696429 | The aim of this review is to describe the pharmacological mechanism, clinical evidence and prescribing guidelines concerning azithromycin in COVID-19 patients. | 2020-07-23 |
| 32696443 | Further, we are months away from a robust vaccination effort, and current therapies provide limited clinical relief. […] More recently, less severe patients at the edge of impending hypoxemia were exposed to HBO preventing intubation and obtaining the rapid resolution of symptoms. | 2020-07-23 |
| 32696465 | Clinical recovery does not mean full recovery. […] The laboratory parameters were compared between COVID-19 and control patients as well as severe and moderate COVID-19 patients from the clinical recovery stage to the 4 weeks postdischarge recovery stage. […] A higher RDW-CV level and neutrophil percentage and lower levels of total proteins, lymphocytes, eosinophils, and MCH were found in COVID-19 patients compared with those in controls from the clinical recovery to the postdischarge recovery stages. | 2020-07-23 |
| 32696473 | The novel coronavirus disease 2019 (COVID-19), characterized by symptoms of fever and pneumonia, was reported in Wuhan, China at the end of 2019 (Phelan, Katz, & Gostin, 2020). […] Given the likely transmission of COVID-19 via droplets and aerosols during dental clinical procedures, dental practitioners are at a high risk of COVID-19 infections (Ather, Patel, Ruparel, Diogenes, & Hargreaves, 2020). | 2020-07-23 |
| 32696489 | Cytokine storm syndrome (CSS) is a critical clinical condition induced by a cascade of cytokine activation, characterized by overwhelming systemic inflammation, hyperferritinaemia, haemodynamic instability and multiple organ failure (MOF). […] Here, we summarize the pathogenesis, clinical manifestation of CSS, and highlight the current understanding about the recognition and potential therapeutic options of CSS in COVID-19. | 2020-07-23 |
| 32696665 | We hypothesize that since a pro-inflammatory state may worsen COVID-19 prognosis, modulating systemic inflammation through dietary modification may be efficacious in improving the clinical sequelae of COVID-19. | 2020-07-23 |
| 32696720 | Given that these molecules are effective antivirals with excellent safety track records in humans against various ailment, we recommend their potential repurposing for the treatment of SARS-CoV-2 patients after successful clinical studies. | 2020-07-23 |
| 32696735 | To date, there have been no detailed reports of patients developing persistent psychotic symptoms following Coronavirus disease 2019 (COVID-19) infection. […] We report on a female patient who, post-COVID-19 infection, developed an initial delirium followed by persistent and florid psychotic symptoms consisting of persecutory delusion, complex visual and auditory hallucinations and Capgras phenomenon in the absence of hypoxia but elevated tumour necrosis factor (TNF)-α. […] The psychotic symptoms persisted for about 40 days. […] The cause of the psychotic symptoms in this patient were not ascertained but we propose either an inflammatory state, characterised by the patient’s elevated TNF-alpha levels as a possible contributing mechanism for her psychosis in line with the proinflammatory changes observed in some cases of psychosis. | 2020-07-23 |
| 32696759 | Through retrospective analysis of existing anti-virus researches and clinical application results of NK cells, and based on the characteristics and properties of this cell, we designed a plan for NK cells to treat COVID-19. […] Many clinical applications have proved the safety and effectiveness of NK cell application. | 2020-07-23 |
| 32696772 | Interestingly, many of these identified candidates (12 molecules from workflow-I and several molecules, belonging to the chemical classes of alkaloids, tetracyclines, peptidomimetics, from workflow-II) are suggested to possess anti-viral properties, which is supported by laboratory and clinical data. | 2020-07-23 |
| 32696861 | The demographic, clinical, and laboratory [NLR, platelet/lymphocyte ratio (PLR), complete blood count, biochemistry, and serology] data of the patients were retrospectively obtained from the hospital data management system. | 2020-07-23 |
| 32696862 | There is in vitro and in vivo information available for coronaviruses, as well as an extensive clinical safety database (from a clinical trial of the Ebola virus and in the context of the Monitored Emergency Use of Unregistered and Investigational Interventions - MEURI). | 2020-07-23 |
| 32697060 | There is usually chronicity of symptoms in TB as compared to acute or rapid progression in COVID-19. | 2020-07-23 |
| 32697082 | Rapid but yet sensitive, specific, and high-throughput detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in clinical samples is key to diagnose infected people and to better control the spread of the virus. […] In this proof-of-concept study, simili nasopharyngeal swabs spiked with different quantities of purified SARS-CoV-2 viral material were used to develop a nanoLC-MS/MS acquisition method, which was then successfully applied on COVID-19 clinical samples. | 2020-07-23 |
| 32697171 | Advancing community pharmacy-based MOUD for leading clinical management of OUD and dispensation of treatment medications will afford the US a critical innovation for addressing the opioid epidemic, fallout from COVID-19, and getting individuals the care they need. | 2020-07-23 |
| 32697172 | Hence, we discuss: (1) why persons with substance use disorders are at increased risk for infection with COVID-19 and a severe illness course; (2) anticipated adverse consequences of COVID-19 in persons with substance use disorders; (3) challenges to health care delivery and substance use treatment programs during and after the COVID-19 pandemic; and (4) the potential impact on clinical research in substance use disorders. […] We offer recommendations for clinical, public health, and social policies to mitigate these challenges and to prevent negative outcomes. | 2020-07-23 |
| 32697344 | The most common symptoms of COVID-19 are fever, sore throat, and shortness of breath. | 2020-07-23 |
| 32697357 | A total of 9995 clinical specimens were analyzed, including nasopharyngeal swabs, bronchoalveolar lavage fluids, gargle lavages, stools, pleural fluids, and cerebrospinal fluids. | 2020-07-23 |
| 32697491 | Clinical studies, reviews, and guidelines were selected and reviewed by all authors and discussed by internet conference and email. […] A triage algorithm based on clinical estimations of the incremental survival benefit (saving the most life-years) provided by ICU care is proposed. […] Although the algorithm improves consistency and provides practical and psychologic support to those performing triage, the final decision remains a clinical one. | 2020-07-23 |
| 32697506 | Of 178 potentially eligible patients with symptoms of coronavirus disease 2019, 23 patients (12.92%) were diagnosed as suspected cases, and one patient (0.56%) suffered from cardiac arrest immediately after admission. […] Acute Physiology and Chronic Health Evaluation II score was an effective clinical tool to predict hospital mortality in patients with coronavirus disease 2019 compared with Sequential Organ Failure Assessment score and CURB65 score. […] Acute Physiology and Chronic Health Evaluation II score greater than or equal to 17 serves as an early warning indicator of death and may provide guidance to make further clinical decisions. | 2020-07-23 |
| 32697692 | Furthermore, a significant difference (p = 0.000) also shows on the Symptoms of Hypochondriasis between exposure to COVID-19. | 2020-07-23 |
| 32697705 | The protocol includes the following main areas: (1) ECT unit’s structural and functional considerations; (2) SARS-CoV-2 screening protocol; (3) ECT clinical practice adaptation (personal protective equipment, airway management, recovery room, and maintenance of the facilities); (4) management of COVID-19 cases; and (5) protocol assessment. | 2020-07-23 |
| 32697835 | To find the factors that potentially protect females from COVID-19, we recruited all confirmed patients hospitalized at three branches of Tongji Hospital (n=1902) from January 28 to March 8, 2020, and analyzed the correlation between menstrual status (n=509，including 68 from Mobile Cabin Hospital)/female hormones (n=78)/ cytokines related to immunity and inflammation(n=263), and the severity/clinical outcomes in female patients under 60 years of age.Non-menopausal female patients had milder severity and better outcome compared with age-matched men (p<0.01/p<0.01). | 2020-07-23 |
| 32697870 | Retrospective analysis of clinical data of 675 patients with COVID-19 in Zhongnan Hospital of Wuhan University from January 3 to March 8, 2020. | 2020-07-23 |
| 32697970 | Although clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation on transmission, disease, and vaccine and therapeutic development are largely unknown. | 2020-07-23 |
| 32698080 | The clinical data of all patients who underwent a neurosurgical intervention between May 4, 2020, and June 4, 2020 were obtained from a prospectively maintained database. […] Data of the control group were retrospectively collected from the medical records to compare the types of surgeries/interventions and clinic visits performed by the same neurosurgical service before the COVID-19 pandemic started. | 2020-07-23 |
| 32698095 | We speculate that an immune mechanism induced by SARS-CoV-2, which can activate lymphocytes and an inflammatory response, plays a role in the clinical onset of the disease. | 2020-07-23 |
| 32698191 | Several clinical studies are ongoing to evaluate the efficacy of repurposed drugs that have demonstrated antiviral efficacy in vitro. | 2020-07-23 |
| 32698192 | Several of these monoclonal antibodies are promising candidates for clinical development as potential therapeutic and/or prophylactic agents against SARS-CoV-2. | 2020-07-23 |
| 32698230 | Successful homeopathic prescriptions are based on careful individualization of symptoms, either for an individual patient or collectively in the case of epidemic outbreaks. […] As a result, clinical presentation is variable, in addition to variations associated with several individual and collective risk factors. […] Given the extreme variability of pathology and clinical manifestations, a single, or a few, universal homeopathic preventive Do not split medicine(s) do not seem feasible. | 2020-07-23 |
| 32698320 | In this work 595 health care workers from a public company were tested for Severe acute respiratory syndrome coronavirus 2 (82 positive) and asked to complete a questionnaire on early COVID-19 symptoms. […] Respiratory symptoms were present in 56.1% of cases. […] About one in three of the cases (29.3%) never manifested symptoms. | 2020-07-24 |
| 32698369 | A group of experts from the Spanish Association of Sexuality and Mental Health (AESexSAME) has reached a consensus on recommendations to maintain lower-risk sexual activity, depending on one’s clinical and partner situations, based on the current knowledge of SARS-CoV-2. […] Different situations are included in the recommendations: a sexual partner passing quarantine without any symptoms, a sexual partner that has not passed quarantine, a sexual partner with some suspicious symptoms of COVID-19, a positive sexual partner with COVID-19, a pregnant sexual partner, a health professional partner in contact with COVID-19 patients, and people without a sexual partner. […] In all other cases (for those under quarantine, those with some clinical symptoms, health professionals in contact with COVID-19 patients, and during pregnancy), abstaining from coital/oral/anal sex, substituting it with masturbatory or virtual sexual activity to provide maximum protection from the contagion, and increasing the benefits inherent to sexual activity are recommended. | 2020-07-24 |
| 32698494 | Moreover, clinical trials have demonstrated safe application of RNA viral vectors and even promising results in rhabdovirus-based phase III trials on an Ebola virus vaccine. […] Preclinical and clinical applications of self-amplifying RNA viral vectors have proven efficient for vaccine development and due to the presence of RNA replicons, amplification of RNA in host cells will generate superior immune responses with significantly reduced amounts of RNA delivered. | 2020-07-24 |
| 32698646 | The lack of understanding of this pandemic epidemiological characteristics, clinical implications and long term consequences have raised concern among healthcare workers. […] No newborn developed clinical evidence of infection. | 2020-07-24 |
| 32698669 | Our initial clinical experience suggests that the acquisition of portable chest radiographs through the glass doors of isolation rooms is technically feasible and results in diagnostic quality studies. | 2020-07-24 |
| 32698853 | There is a strong association between the extent of the coagulopathy and poor clinical outcomes.The anti-coagulant actions of nebulised UFH limit fibrin deposition and microvascular thrombosis. […] Trials in patients with acute lung injury and related conditions found inhaled UFH reduced pulmonary dead space, coagulation activation, microvascular thrombosis and clinical deterioration, resulting in increased time free of ventilatory support. […] Furthermore, clinical studies have shown that inhaled UFH safely improves outcomes in other inflammatory respiratory diseases and also acts as an effective mucolytic in sputum-producing respiratory patients. […] UFH is widely available and inexpensive, which may make this treatment also accessible for low- and middle-income countries.These potentially important therapeutic properties of nebulised UFH underline the need for expedited large-scale clinical trials to test its potential to reduce mortality in COVID-19 patients. | 2020-07-24 |
| 32698862 | All the included studies are based on clinical surveys among patients with confirmed SARS-CoV-2 infection. | 2020-07-24 |
| 32698898 | Current clinical management strategies are respiratory support and restricted fluid input, and there is no suggested pharmacological treatment. […] In this review, we will focus on clinical progress in the use of MSCs as a cell therapy for ARDS, which may have clinical implications during the coronavirus disease 2019 (COVID-19) pandemic. | 2020-07-24 |
| 32698948 | Radiologists’ image reading skills vary, such variations in image interpretations can influence the effectiveness of the early treatment of disease and may have important clinical and economic implications. […] In screening mammography, clinical audits are used to assess radiologists’ performance annually, however, the nature of these audits prevent robust data analysis due to the low prevalence of breast cancer and the long waiting periods for the audit results. | 2020-07-24 |
| 32699031 | Treatment receipt reflects clinical decision-making and suggests disparities in medication access.This article is highlighted in the In This Issue feature, p. | 2020-07-24 |
| 32699149 | Both populations were comparable for age, comorbidities, clinical stage, and elevated biomarkers of systemic inflammation. | 2020-07-24 |
| 32699166 | Yet the clinical features and long-term outcomes of neonates with SARS-CoV-2 exposure are lacking. […] The purpose of this study is to describe the clinical course and prognosis of the neonates exposed to SARS-CoV-2. […] The data to be collected via case report forms include demographic details, clinical features, laboratory and imaging results, as well as outcomes. […] The study findings will be disseminated in peer-reviewed journals and presented at national and international conferences in order to improve the understanding of the clinical course among neonates exposed to SARS-CoV-2 and to provide evidence-based treatment and prevention strategies for this group. | 2020-07-24 |
| 32699167 | To explore the potential of using wearable biosensors to continuously monitor multidimensional physiological parameters for early detection of COVID-19 clinical progression. | 2020-07-24 |
| 32699182 | Some clinical symptoms and radiological findings of pneumonitis can be attributed to the coronavirus infection as well as to an immune-related adverse event. […] Accurate attention should be payed to symptoms like cough, fever and dyspnea during immunotherapy. | 2020-07-24 |
| 32699203 | Respiratory symptoms and gastrointestinal symptoms are often reported among these patients. | 2020-07-24 |
| 32699423 | Data were acquired through a structured interview that included questions about the isolation course, symptoms, comorbidities, infection source, household characteristics, occupation, and workplace. | 2020-07-24 |
| 32699547 | Early diagnosis and prompt treatment are important to achieve optimal treatment outcome in KD. | 2020-07-24 |
| 32699613 | The current issue of Clinical Kidney Journal presents 15 articles on COVID-19 and kidney disease from three continents, providing a global perspective of the impact of severe acute respiratory syndrome coronavirus 2 on electrolytes and different kidney compartments (glomeruli, tubules and vascular compartments) and presenting clinically as a syndrome of inappropriate antidiuretic hormone secretion, acute kidney injury, acute kidney disease, collapsing glomerulopathy and thrombotic microangiopathy, among others, in the context of a brand-new cardiorenal syndrome. […] Finally, current therapeutic approaches and potential future therapeutic approaches undergoing clinical trials, such as complement targeting by eculizumab, are also presented. | 2020-07-24 |
| 32699615 | The clinical spectrum of coronavirus disease 2019 (COVID-19) infection ranges from asymptomatic infection to severe pneumonia with respiratory failure and even death. […] In this review we discuss the chronic immunologic changes observed in CKD patients, the risk of COVID-19 infections and the clinical implications for and specific COVID-19 therapy in CKD patients. | 2020-07-24 |
| 32699677 | The clinical presentation of complicated appendicitis (CA) in association with COVID-19 may not be different from that in the general population. | 2020-07-24 |
| 32699679 | Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to almost every country on the globe, and each country is reporting the symptomatic presentation of their patients to give better insight into the various clinical presentations of SARS-CoV-2. […] Patients’ demographics, symptoms, travel and contact history, and outcomes were recorded. […] The three most common presenting symptoms were fever (74.8%), cough (60.4%), and flu (35.5%). […] There is a need to educate the population about the most common sign and symptoms of the virus so that individuals can identify these symptoms and get themselves tested. | 2020-07-24 |
| 32699689 | Clinical courses of COVID-19 are variable and unpredictable, while some epidemiologic and clinical factors have been found to have a negative impact on the disease prognosis. […] Despite a growing report on clinical characteristics and prognosis of patients with COVID-19, the data in the special population, including transplant recipients, is still limited. […] Herein we report on the clinical features and fatal outcome of COVID-19 in a dual pancreas-kidney transplant recipient (with failure of the pancreas graft). | 2020-07-24 |
| 32699691 | Considering the limitations of this resource-intensive therapy, clinical judgment is crucial to decide whether ECMO is an appropriate option for the patient. | 2020-07-24 |
| 32699707 | In our study, we aimed to describe the clinical characteristics of the first 100 hospitalized patients of confirmed COVID-19 in a developing country. […] Materials and methods The study included all the admitted patients (n = 100) having COVID-19 polymerase chain reaction (PCR) positive, and evaluated clinical profiles and characteristics of the patients linking to disease severity. […] The mean age was 52.58 ± 15.68, with most frequent comorbidities are diabetes and hypertension while frequent symptoms are fever and dry cough. | 2020-07-24 |
| 32699721 | This may prepare students for their clinical experiences when COVID-19 restrictions are lifted. | 2020-07-24 |
| 32699768 | With the COVID-19 pandemic disrupting many facets of our society, physicians and patients have begun using telemedicine as a platform for the delivery of health care. | 2020-07-24 |
| 32699972 | Children with Coronavirus Disease 2019 (COVID-19) were reported to show milder symptoms and better prognosis than their adult counterparts, but the difference of immune response against SARS-CoV-2 between children and adults hasn’t been reported. | 2020-07-24 |
| 32700004 | This retrospective study analyzes the clinical data of 29 consecutive patients with pulmonary contusion, including two with COVID-19, at Tongji Hospital, Wuhan, China, in January and February, 2020. […] We analyzed the clinical manifestations, laboratory test results, computed tomography (CT) images, treatment, and clinical outcomes. | 2020-07-24 |
| 32700005 | Their postoperative outcomes did not differ from those in our routine clinical practice, with a 0% respiratory failure rate and a 7.14% mortality rate, in contrast with other published series. | 2020-07-24 |
| 32700055 | Testable hypotheses derived from these concepts are that biomarkers of EAS activation correlate with clinical and pathophysiologic data and predict outcome in COVID-19 and that treatments targeting specific abnormalities identified in individual patients may be beneficial. | 2020-07-24 |
| 32700223 | Thus, there needs to be a comprehensive plan for preventing and managing post-COVID-19 complications to quell their clinical, economic, and public health consequences and to support patients experiencing delayed morbidity and disability as a result. | 2020-07-24 |
| 32700247 | Against SARS-CoV-2 and homologous viruses, CEP predominantly inhibits viral entry and replication at low doses; and was recently identified as the most potent coronavirus inhibitor among 2406 clinically approved drug repurposing candidates in a preclinical model. | 2020-07-24 |
| 32700336 | Non-steroidal anti-inflammatory drugs (NSAIDs) are medicines very widely used to alleviate fever, pain, and inflammation (common symptoms of COVID-19 patients) through effectively blocking production of prostaglandins (PGs) via inhibition of cyclooxyganase enzymes. | 2020-07-24 |
| 32700434 | All (N = 103) patients sequentially admitted from 4 to 27 April 2020 with no symptoms or evidence of COVID-19 disease at the time of transfer from the acute hospital. […] Results of SARS-CoV-2 testing upon admission and evidence of development of clinical signs or symptoms of COVID-19. […] Seven asymptomatic persons (6.8% of admissions) without clinical signs/symptoms of COVID-19 tested positive on admission. […] Of these, five developed symptoms of COVID-19, with a mean onset of 3.2 (range of 2-5) days. | 2020-07-24 |
| 32700510 | In this review we will present recent information about the SARS-CoV-2 focusing on the origin, clinical picture, diagnostic methods, structure, replication cycle of SARS-CoV-2 and potential pharmaceutical measures against COVID-19. | 2020-07-24 |
| 32700555 | Its major clinical presentation is characterized by respiratory symptoms ranging from mild cough to serve pneumonia with fever and potentially even death. […] Until today, there is no known medication to improve clinical symptoms or even prevent or fight the infection. […] In this review, we highlight hydroxychloroquine (HCQ) as a potential agent to prevent coronavirus disease 2019 (COVID-19) and reduce as well as shorten clinical symptoms. […] Although it has been used in the treatment of rheumatoid arthritis, discoid or systemic lupus erythematosus, and malaria prophylaxis and therapy for decades, knowledge on HCQ as a potential treatment for COVID-19 is limited and multiple clinical trials have just emerged. | 2020-07-24 |
| 32700561 | Here we focus on the role of serum ferritin for diagnostic and clinical management of patients with COVID-19 in comparison with other infectious and non-infectious diseases.METHODS: We examined scientific articles listed in PubMed reporting on ferritin in various infectious and non-infectious diseases. | 2020-07-24 |
| 32700573 | An individualized approach to medication management among hospitalized COVID-19 patients with concurrent CVDs would seem prudent with attention paid to changes in clinical conditions and medications intended for COVID-19. | 2020-07-24 |
| 32700580 | Thus, there existed clinical uncertainty. […] Here, we review studies implicating 15 classes of drugs in increasing ACE2 levels in vivo and the available literature on the clinical safety of these drugs in COVID-19 patients. […] Further, in a re-analysis of clinical data from a meta-analysis of 9 studies, we show that ACEIs/ARBs usage was not associated with an increased risk of all-cause mortality. […] For definitive clarity, further clinical and mechanistic studies are needed in assessing the safety of all classes of ACE2 raising medications. | 2020-07-24 |
| 32700604 | Of the 15-20% patients that develop pulmonary symptoms, a sub-set develops an acute respiratory distress syndrome (ARDS) rapidly progressing into a critical condition. | 2020-07-24 |
| 32700681 | Its severe clinical manifestations associated with the need for admission into Intensive Care Units and high mortality rate represent a therapeutic challenge for the medical community. […] Currently, there is no drug approved for its treatment and different therapeutic options are being essayed to address pathophysiological processes underlying the clinical manifestations experienced by patients. […] Thus, the probability of more adverse reactions or even new clinical manifestations may increase in the near future. | 2020-07-24 |
| 32700795 | The fundamental objective is to identify, and provide to the international scientific community, hit molecules potentially suitable to enter the drug discovery process, preclinical validation and development. | 2020-07-24 |
| 32701196 | We seek to add to the current limited literature on COVID-19 in transplant recipients by describing the clinical course of two kidney transplant recipients with SARS-CoV-2 infection monitored by both RT-PCR and serology. | 2020-07-24 |
| 32701240 | To identify the key biochemical indicators that affect the clinical type and outcomes of COVID-19 patients and explore the application of neutrophil/lymphocyte ratio (NLR) in COVID-19. […] Based on the patients’ outcomes, NLR cutoff value classification and clinical classification, multiple binary logistics regression was performed to screen the key variables and explore their significance in COVID-19. […] NLR, WBC, NEUT, PCT, DD, BUN, TNI, BNP, and LDH had significant effects on the clinical classification and outcome of the patients (P < 0.05); Cr, Ca, PH, and Lac had greater impact on the outcome of the patients (P < 0.05), while Na, PCO2 had greater impact on the clinical classification of the patients (P < 0.05). […] NLR can be used as an important reference for clinical classification, prognostic assessment, and biochemical abnormalities of COVID-19. | 2020-07-24 |
| 32701376 | We collected all patients’ clinical characteristics and some laboratory indicators at the time of admission and conducted Logistic regression analysis after comparing the differences between groups. | 2020-07-24 |
| 32701431 | Community pharmacists are in a key position to deliver priority pandemic responses including point-of-care testing for chronic disease management, vaccinations, and COVID-19 testing. | 2020-07-24 |
| 32701511 | The clinical and immunologic spectrum of MIS-C and its relationship to other inflammatory conditions of childhood have not been studied in detail.METHODSWe retrospectively studied confirmed cases of MIS-C at our institution from March to June 2020. […] The clinical characteristics, laboratory studies, and treatment response were collected. […] Clinical and laboratory improvement were observed in all cases, including 6 cases that did not require immunomodulatory therapy. […] No mortality was recorded in this cohort.CONCLUSIONMIS-C encompasses a broad phenotypic spectrum with clinical and laboratory features distinct from KD and MAS.FUNDINGThis work was supported by the National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases; the National Institute of Allergy and Infectious Diseases; Rheumatology Research Foundation Investigator Awards and Medical Education Award; Boston Children’s Hospital Faculty Career Development Awards; the McCance Family Foundation; and the Samara Jan Turkel Center. | 2020-07-24 |
| 32701558 | The COVID-19 pandemic poses an unprecedented challenge to U.S. health systems, particularly academic health centers (AHCs) that lead in providing advanced clinical care and medical education. […] No phase of AHC efforts is untouched by the crisis, and medical schools, prioritizing learner welfare, are in the throes of adjusting to suspended clinical activities and virtual classrooms. […] While health professions students are currently limited in their contributions to direct clinical care, they remain the same smart, innovative, and motivated individuals who chose a career in health care and who are passionate about contributing to the needs of people in troubled times. […] The groundwork for operationalizing their commitment has already been established through the identification of value-added, participatory roles that support learning and professional development in health systems science (HSS) and clinical skills. | 2020-07-24 |
| 32701630 | The two patients were selected based upon clinical criteria and elevated levels of IL-6 (> 100 pg/mL) as a biomarker of inflammation. […] A multicenter clinical trial is underway with a FDA-approved Investigational Device Exemption to evaluate the potential of SCD therapy to effectively treat COVID-19 ICU patients. | 2020-07-24 |
| 32701690 | We had the opportunity to examine the clinical and histopathological features of several patients who were divided into 3 groups. […] The presence of urticarial lesions, chilblains, targetoid lesions (erythema multiforme-like lesions), exanthema, maculohemorrhagic rash, or chickenpox-like lesions associated with the histopathological features mentioned previously should cause clinical dermatologists to suspect the possibility of COVID-19 infection, especially in patients with fever and cough. | 2020-07-24 |
| 32701763 | A 27-year-old primigravid woman presented with mild COVID-19 symptoms at 28 2/7 weeks of gestation, testing positive for SARS-CoV-2 infection by nasopharyngeal swab reverse transcription-polymerase chain reaction (RT-PCR). | 2020-07-24 |
| 32701910 | The COVID-19 hit the world with devastating clinical, economic and social burden. | 2020-07-24 |
| 32701912 | These findings need to be integrated with epidemiological and clinical data. | 2020-07-24 |
| 32701913 | While the knowledge on the acute phase of the disease has rapidly expanded, little is known on the consequences of COVID-19 following clinical remission. […] We set up a multidisciplinary COVID-19 follow-up outpatient clinic to identify and address the clinical needs of COVID-19 survivors. | 2020-07-24 |
| 32701915 | One third (33%) focused on COVID-19 clinical management, with little adherence to identified research priorities. […] Never before in the history of academic publishing such a great volume of research focused on a single topic, this being likely to introduce major changes in the way science is produced and communicated, at the risk of bringing it far from its ultimate aim: informing clinical and public health practice and decision making. | 2020-07-24 |
| 32701920 | The purpose of the study is to a) describe the importance of a correct management of SARS-CoV-2 infections; b) report the number of positive healthcare workers after the epidemic phase and to describe their socio-characteristics data, the main methods of transmission and the symptoms; c) to report the seroconversion rate of healthcare workers (HCWs). | 2020-07-24 |
| 32701938 | Among 3,658 noninstitutionalized participants in the random sample survey, the estimated statewide point prevalence of active SARS-CoV-2 infection confirmed by reverse transcription-polymerase chain reaction (RT-PCR) testing was 1.74% (95% confidence interval [CI] = 1.10-2.54); 44.2% of these persons reported no symptoms during the 2 weeks before testing. | 2020-07-24 |
| 32701969 | Hydroxychloroquine (HCQ) has in vitro activity against SARS-CoV-2, but clinical data supporting HCQ for coronavirus disease 2019 (COVID-19) are limited. | 2020-07-24 |
| 32702044 | To determine the demographic and clinical characteristics associated with increased severity of Covid-19 infection. […] Several clinical associations were more pronounced in younger compared to older patients (Pinteraction<0.05). | 2020-07-24 |
| 32702065 | Furthermore, students’ levels of stress, anxiety, loneliness, and depressive symptoms got worse, compared to measures before the crisis. | 2020-07-24 |
| 32702087 | The prevalence and clinical significance of cardiovascular and multisystem involvement in COVID-19 remain unclear. | 2020-07-24 |
| 32702098 | These findings suggest that continued ACEi/ARB use in hypertensive COVID-19 patients yields better clinical outcomes. | 2020-07-24 |
| 32702150 | The aim of this review was to summarize the existing literature specifically in kidney transplant (KTx) recipients, with an emphasis on the epidemiology, clinical presentation, laboratory findings, post-operative outcomes, and therapeutic strategies currently employed. […] The most common symptoms are predominantly respiratory and associated with fever. […] The majority of patients with severe symptoms have been managed with reduction of immunosuppression, including decreased doses of CNIs and withdrawal of MMF. | 2020-07-24 |
| 32702153 | The most common presenting symptoms were fever (80.5%), cough (63.4%), and fatigue (41.5%). | 2020-07-24 |
| 32702176 | Endoscopy is widely used as a clinical diagnosis and treatment method for certain hepatobiliary and pancreatic diseases. | 2020-07-24 |
| 32702192 | To explore the role of resilience in anxiety and depression and to clarify their relationships among patients with mild symptoms of coronavirus disease 2019 (COVID-19) in Wuhan, China. […] In total, 296 patients from FangCang Hospital in Wuhan, Hubei, China, with mild symptoms of COVID-19 were recruited. […] Health professionals, especially clinical nurses, need to be aware of the psychological status of COVID-19 patients and promote resilience to improve their mental health. | 2020-07-24 |
| 32702224 | One was a young patient who developed COVID-19 symptoms and tested positive for the SARS-CoV-2 virus while receiving clozapine and the other was an aging man who tested negative for the SARS-CoV-2 virus but had contact with COVID-19 during initiation of clozapine treatment. […] These cases suggest that, in the absence of complications, exposure to COVID-19 per se and the onset of mild symptoms in those infected may not warrant withdrawal or postponement of clozapine treatment when this is indicated. | 2020-07-24 |
| 32702298 | Healthy adults aged 18-55 years with no history of laboratory confirmed SARS-CoV-2 infection or of COVID-19-like symptoms were randomly assigned (1:1) to receive ChAdOx1 nCoV-19 at a dose of 5 × 1010 viral particles or MenACWY as a single intramuscular injection. […] UK Research and Innovation, Coalition for Epidemic Preparedness Innovations, National Institute for Health Research (NIHR), NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland’s NIHR Clinical Research Network, and the German Center for Infection Research (DZIF), Partner site Gießen-Marburg-Langen. | 2020-07-24 |
| 32702415 | We analyzed their clinical and demographic data, laboratory parameters, radiological findings, symptoms, and treatment outcomes. | 2020-07-24 |
| 32702465 | The aim of this study was to describe the epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19) among HCWs from February 24th to April 30th, 2020, in a hospital in Madrid, Spain. […] The prevalence of comorbidities was low and 91.5% of patients had mild or moderate symptoms. […] In spite of a low prevalence of comorbidities and a mild clinical course in most cases, COVID-19 caused long periods of sick leave. | 2020-07-24 |
| 32702641 | Data on the socio-demographic and clinical characteristics of 95 RRMS patients were collected. | 2020-07-24 |
| 32702822 | All published randomized controlled trials, clinical controlled trials, case-control, and case series that meet the pre-specified eligibility criteria will be included. […] Primary outcome measures include mortality, clinical recovery rate, duration of fever, progression rate from mild or moderate to severe, improvement of symptoms, biomarkers of laboratory examination and changes in computed tomography. | 2020-07-25 |
| 32702851 | To ensure achievement of predefined learning outcomes, participants had to undergo a final simulator-based objective structured clinical examination.In March 2020, 45 emergency medical assistants and 1 physician of the Austrian Red Cross participated on a voluntary basis. […] Forty-five of the 46 participants (97.8%) completed the curriculum successfully, with mean objective structured clinical examination ratings of 98.6%. […] Based on simulation-based objective structured examinations, it has prepared participants effectively for preclinical duties. | 2020-07-25 |
| 32702935 | In this report, a 35 day-old male infant with atypical symptoms had close contact with 2 confirmed patients of COVID-19 who were his grandmother and mother. […] Strengthening infants’ virus screening in families with infected kins is important for early diagnosis, isolation, and treatment when symptoms are atypical. | 2020-07-25 |
| 32702940 | Both at the stage of diagnostics prior to admission to the intensive care unit and during the monitoring of lesion evolution, diagnostic imaging techniques may significantly influence clinical decisions. | 2020-07-25 |
| 32703010 | The patient had no symptoms of fever, cough, shortness of breath, or fatigue. | 2020-07-25 |
| 32703036 | With the development of various branches of sciences, we will be able to resolve different clinical aspects of various diseases better. | 2020-07-25 |
| 32703064 | To date, countries have relied on the prevention of the disease through isolation, quarantine, and clinical care of affected individuals. | 2020-07-25 |
| 32703069 | Currently, more than 115 vaccine candidates have been developed from different technology platforms with several of them in clinical trials. | 2020-07-25 |
| 32703209 | In clinical work, accurate identification of various chest CT signs can help to improve the diagnostic accuracy of COVID-19 and reduce the misdiagnosis or missed diagnosis rate. | 2020-07-25 |
| 32703328 | Therefore, we have analysed: (1) the structure of SARS-CoV-2 and SARS-CoV; (2) the clinical signs and symptoms and pathogenic mechanisms observed during the development of acute respiratory syndrome and the cytokine release syndrome; (3) the modification of the cell microRNome and of the immune response in patients with SARS infection; and (4) the possible role of some fat-soluble compounds (such as vitamins A, D and E) in modulating directly or indirectly the replication ability of SARS-CoV-2 and host immune response. | 2020-07-25 |
| 32703538 | The clinical management of COVID-19 is challenging. […] Medical imaging plays a critical role in the early detection, clinical monitoring and outcomes assessment of this disease. | 2020-07-25 |
| 32703607 | Since December 2019, COVID-19, the clinical syndrome associated with SARS-CoV-2 infection, has infected more than 6.2 million people and brought the function of the global community to a halt. | 2020-07-25 |
| 32703664 | The collection and clinical use of COVID-19 convalescent plasma (CCP) as a therapy for COVID-19 infection is under development and early use in many centers worldwide. […] Sixty-four studies in 22 countries were identified from clinical trial registries and personal contacts of the authors. | 2020-07-25 |
| 32703730 | The recorded answers were consistent among different regions, and did not show any north-south gradient CONCLUSION: COVID-19 outbreak significantly impacted on hepatological clinical activity. | 2020-07-25 |
| 32703783 | COVID-19 pandemic of 2020 has impacted all aspects of clinical practice in the UK. | 2020-07-25 |
| 32703797 | Symptoms and ARDS duration were 14 (SD 7) and 6 days (SD 3). | 2020-07-25 |
| 32703883 | These data suggest HFNC to be a safe treatment for less severe patients with SARS-CoV-2 hARF and efficacy will need to be assessed as part of a clinical trial. | 2020-07-25 |
| 32703894 | In this commentary, we provide a broad overview of how the rapidly evolving coronavirus disease 2019 (COVID-19) diagnostic landscape has impacted clinical care during the COVID-19 pandemic. | 2020-07-25 |
| 32703897 | In early March 2020, the University of Washington Medical Center clinical virology laboratory became one of the first clinical laboratories to offer testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). | 2020-07-25 |
| 32703929 | The clinical presentation of COVID-19 in kidney transplant recipients may be different from the general population with a higher rate of severe disease, complications including renal failure, and mortality. | 2020-07-25 |
| 32704169 | A robust serological test to detect neutralizing antibodies to SARS-CoV-2 is urgently needed to determine not only the infection rate, herd immunity and predicted humoral protection, but also vaccine efficacy during clinical trials and after large-scale vaccination. […] The surrogate virus neutralization test does not require biosafety level 3 containment, making it broadly accessible to the wider community for both research and clinical applications. | 2020-07-25 |
| 32704368 | The survey was administered online via the google docs survey tool from medical laboratory professionals (n = 64) serving at the section of Clinical Chemistry, department of Pathology and Laboratory Medicine, the Aga Khan University (AKU), Pakistan from June 4th to 14th 2020. […] A team consisting of three Clinical Chemistry consultants serving as faculty at the section, designed the survey questionnaire. | 2020-07-25 |
| 32704451 | The COVID-19 outbreak had a major impact on the experiments of researchers in the life sciences, especially in basic and clinical medicine. | 2020-07-25 |
| 32704455 | To address this immuno-inflammatory pathogenesis, multiple clinical trials have been proposed to evaluate anti-inflammatory biologic therapies targeting specific cytokines. […] However, despite the obvious clinical utility of such biologics, their specific applicability to COVID-19 has multiple drawbacks, including they target only one of the multiple cytokines involved in COVID-19’s immunopathy. […] Our pre-clinical data suggest that it may be a candidate for repurposing as an inhaled therapy against COVID-19. | 2020-07-25 |
| 32704470 | It has significantly affected the dental professionals in their clinical practices, hospitals and even dental schools. | 2020-07-25 |
| 32704471 | To describe a case of recurrent positive nucleic acid detection in a recovered coronavirus disease 2019 (COVID-19) patient and to provide clinical data for the further study of COVID-19. | 2020-07-25 |
| 32704477 | These five cases of fetal demise in women with confirmed COVID-19 without any other significant clinical or obstetric disorders suggest that fetal death can be an outcome of SARS-CoV-2 infection in pregnancy. | 2020-07-25 |
| 32704513 | This study investigated epidemiological, clinical, and radiological characteristics of COVID-19 with negative RT-PCR results before confirmation. […] Epidemiological and clinical features were compared. […] No significant differences were observed in clinical symptoms between the 2 groups. […] We found that fever was the most common symptom for both groups, followed by cough, expectoration, chest distress, fatigue, and gastroenterological symptoms. […] Regardless of initial RT-PCR results, patients with COVID-19 had similar epidemiological, clinical, and chest CT features. […] Our study suggests value from early chest CT scans in COVID-19 screening and dynamic significance of radiology in disease monitoring should guide clinical decisions. | 2020-07-25 |
| 32704517 | SARS-CoV-2 virus testing for persons with COVID-19 symptoms, and contact tracing for those testing positive, will be critical to successful epidemic control. […] Willingness of persons experiencing symptoms to seek testing may determine the success of this strategy. […] There were no significant differences in willingness items across sociodemographic variables or for those currently experiencing COVID-19 symptoms. […] Home specimen collection options could result in up to one-third more symptomatic persons seeking testing, facilitating contact tracing and optimal clinical care. | 2020-07-25 |
| 32704530 | She was also noted to have ST segment elevation myocardial infarction (STEMI) on the electrocardiogram however the imaging and clinical presentation was consistent with apical takotsubo cardiomyopathy. | 2020-07-25 |
| 32704544 | We believe that implementing virtual rotations, delaying the opening of the application, decentralizing clinical skills evaluations, and modifying graduation requirements are possible options among many that could aid in addressing some of the current challenges presented by COVID-19. | 2020-07-25 |
| 32704548 | Introduction: Vaccines and drugs for the treatment and prevention of COVID-19 require robust evidence generated from clinical trials before they can be used. | 2020-07-28 |
| 32704580 | We describe three patients with COVID-19 who presented with an acute vascular event rather than with typical respiratory symptoms. […] The primary presentation of COVID-19 infection as a thrombotic event rather than with respiratory symptoms has not been described elsewhere. | 2020-07-25 |
| 32705079 | At the present time, clinical and forensic autopsies have given guidance and explanations in relation to the problem of COVID-19 transmission and defense. | 2020-07-25 |
| 32705085 | In this report, we describe a clinical-academic partnership whereby a bespoke filter guard was designed to disrupt airflow and prevent gown entrainment, thereby enabling full barrier protection of both the device and user. | 2020-07-25 |
| 32705153 | Therefore, ddPCR is strongly recommended in clinical practice for the diagnosis of COVID‑19 and the follow‑up of positive patients until complete remission. | 2020-07-25 |
| 32705222 | The present study aimed to describe the clinical, laboratory and radiological characteristics of 2019‑nCoV pneumonia (NCP) in Zhejiang province, outside of Wuhan. […] Subsequently, the clinical features between positive‑ and negative‑NCP patients in Zhejiang were compared. […] Compared with non‑NCP patients, the most common symptoms at onset for patients with NCP were fever (5/6; 83.3%) and cough (5/6; 83.3%), followed by dyspnea/pharyngalgia (2/6; 33.3%), whereas myalgia (1/6; 16.7%) and fatigue (1/6; 16.7%) were less common. | 2020-07-25 |
| 32705298 | At the onset of symptoms, a swab of the upper airway is especially suitable due to the high viral burden. | 2020-07-25 |
| 32705361 | We asked our trainees to fill out an electronic survey about several aspect of their training: a first section focused on the reduction of clinical activities and the perceived impact of the pandemic on residents’ skills; the second part outlined the type of attended training activity and the perceived benefit. […] Residents’ suggestions included actively participating to tracheostomy procedures on SARS-CoV-2 positive patients, attending lessons held by senior consultants on basic ENT topics and promoting collegial discussion of inpatient clinical cases. | 2020-07-25 |
| 32705575 | Comparison between patients with different disease severity suggested early seroconversion and high antibody titer were linked with less severe clinical symptoms. | 2020-07-25 |
| 32705587 | Investigation of the prognostic value of these markers for adverse clinical sequelae following COVID-19 disease is urgently needed. | 2020-07-25 |
| 32705604 | Empirical multidrug therapeutic approaches to treat COVID-19 are currently used with extremely uncertain outcomes, and many others are being tested in clinical trials. […] The use of ASA in patients with different types of infections has been associated with reduced thrombo-inflammation and lower rates of clinical complications and in-hospital mortality. […] Hence, whether ASA might be a safe and reasonable therapeutic candidate to be tested in clinical trials involving adults with COVID-19 deserves further attention. […] In this review we provide a critical appraisal of current evidence on the anti-inflammatory, antithrombotic, and antiviral effects of ASA, from both a pre-clinical and a clinical perspective. | 2020-07-25 |
| 32705718 | Of 270 participants surveyed, 223 (82.6%) reported symptoms of ICD. | 2020-07-25 |
| 32705780 | To provide clinical guidance to rheumatology providers who treat children with pediatric rheumatic disease (PRD) in the context of the coronavirus disease 2019 (COVID-19) pandemic. […] Clinical questions and subsequent guidance statements were drafted based on a review of the queries posed by the patients as well as the families and healthcare providers of children with PRD. | 2020-07-25 |
| 32705809 | Preliminary statements addressing clinical questions related to MIS-C and hyperinflammation in COVID-19 were developed based on evidence reports. […] These statements were refined into 40 final clinical guidance statements, accompanied by a flow diagram depicting the diagnostic pathway for MIS-C. | 2020-07-25 |
| 32705860 | One paper was of level 2 (RCT), 7 were of level 3 (2 cohort studies, 2 cross-sectional studies and 3 case-control studies), and 28 papers of level 4 (descriptive studies); 61% of papers reported epidemiological data on clinical presentations, 5 investigated natural history/determining factors, 1 searched prevalence, 2 studies reported on intervention efficacy (though not on harms), and 5 studies looked at health service organization. | 2020-07-25 |
| 32705880 | The mortality rates of vulnerable and minority populations alone suggest a need to re-evaluate clinical decision making protocols, especially given the recently passed Emergency or Disaster Treatment Protection Act, which grants healthcare institutions full immunity from liability stemming from resource allocation/triage decisions. | 2020-07-25 |
| 32705889 | We document the demographics, symptoms experienced, medications required, effectiveness observed, and challenges to high-quality holistic palliative care in 31 patients. […] This will aid colleagues in primary and secondary care settings anticipate common symptoms and formulate management plans. […] Common symptoms were breathlessness (84%) and delirium (77%). […] The majority of patients had symptoms controlled with low doses of morphine and midazolam, and death was rapid. | 2020-07-25 |
| 32705942 | Amongst these drugs, Ritonavir has been used in clinical trials with patients affected by COVID-19 and Nelfinavir showed anti-SARS-CoV-2 activity. | 2020-07-25 |
| 32705945 | Moreover, psychological status also had a direct influence on the clinical course of the disease. | 2020-07-25 |
| 32705976 | To date, only two treatments, remdesivir and dexamethasone, have demonstrated clinical efficacy through randomized controlled trials (RCTs) in seriously ill patients. | 2020-07-25 |
| 32705978 | Her clinical course was complicated by pneumothorax and pneumomediastinum, and, unfortunately, she died 2 days following the admission. | 2020-07-25 |
| 32705981 | Consensus and clinical guidelines about psychotropic drugs and COVID-19 approach, published by scientific societies, governmental entities and drug regulatory agencies were included. […] The COVID-19 pandemic has created new challenges in clinical practice. […] Psychiatric patients are a vulnerable population and often a careful clinical, laboratorial and electrocardiographic evaluation may be needed, particularly in those diagnosed with COVID-19. | 2020-07-25 |
| 32705983 | Transmission dynamics must be studied in repre - sentative pediatric populations with a combination of study designs including rigorous epidemiological studies (e.g. in households, schools, daycares, clinical settings) and laboratory studies while taking into account the social and socio-economic contexts. | 2020-07-25 |
| 32705990 | The results inform the need for a coordinated effort to expand educational efforts outside of the operating room and clinical environment. | 2020-07-25 |
| 32706087 | We found very little published clinical experience with these drugs, consisting mainly of case reports or case series with few patients. […] The results of clinical trials are necessary to clarify the role of these drugs in patients with COVID-19. | 2020-07-25 |
| 32706088 | There is currently no vaccine available for COVID-19 prevention, though others are available in clinical trials. | 2020-07-25 |
| 32706091 | The Coronavirus Disease 2019 (COVID-19) pandemic mainly involves respiratory symptoms, though gastrointestinal (GI) symptoms are increasingly being recognized. […] The primary aim of this study was to assess the prevalence of GI symptoms and digestive comorbidities in a cohort of patients with COVID-19 compared to controls. […] The secondary aim was to determine the association of GI-symptoms and digestive comorbidities with clinical outcomes. […] Inpatients with COVID-19 and controls with similar symptoms and/or radiological findings were enrolled. […] Symptoms at admission and throughout hospitalization were collected as they were comorbidities. […] The measured clinical outcomes were mortality, intensive care unit admission and cumulative endpoint. […] At admission, the prevalence of GI symptoms among COVID-19 patients was 8.8%. […] During hospitalization, the frequency of GI symptoms was higher in patients with COVID-19 than in controls (p=0.004). […] Among patients with COVID-19, the mortality and a cumulative endpoint rates of those with GI symptoms were both lower than for those without GI symptoms (p=0.016 and p=0.000, respectively). […] Our results highlighted the non-negligible frequency of GI symptoms in patients with COVID-19, partly attributable to the therapies implemented. […] In addition, the presence of GI symptoms and digestive comorbidities is associated with better outcomes. […] Most likely, digestive comorbidities do not hinder the host’s immune response against SARS-COV-2, and the occurrence of GI symptoms might be linked to a faster reduction of the viral load via the faecal route. | 2020-07-25 |
| 32706093 | Changes include organizational rearrangement of Otolaryngology Units, with merges and closures that affected a significant portion of them; reallocation of otolaryngology personnel, mainly to COVID-19 wards; reduction of elective clinical and surgical activity, that was mainly limited to oncology and emergency procedures; and execution of screening procedures for SARS-CoV-2 among healthcare providers and patients in otolaryngology units in Italy. | 2020-07-25 |
| 32706293 | Coronavirus disease 2019 (COVID-19) has a clinical course predominated by acute respiratory failure due to viral pneumonia with possible acute respiratory distress syndrome. […] This review highlights the important considerations related to the CV manifestations of COVID-19 infections, describes the mechanisms and clinical presentation of CV injury, and provides practical management and therapy suggestions. | 2020-07-25 |
| 32706306 | The COVID-19 pandemic and resulting cancellation of medical student clinical rotations pose unique challenges to students’ educations, the impact of which has not yet been explored. […] With prolonged suspension of clinical rotations, targeted efforts by medical schools to address these concerns through enhanced virtual curriculum development and advising strategies will become increasingly important. | 2020-07-25 |
| 32706371 | Results of rapid clinical whole-exome sequencing, performed to identify a potential monogenic cause. […] Rapid clinical whole-exome sequencing of the patients and segregation in available family members identified loss-of-function variants of the X-chromosomal TLR7. | 2020-07-25 |
| 32706390 | The objective of this study was to do a systematic review and critical appraisal of the ongoing clinical trials with an aim to provide insight into the various interventions tested, clinical rationale, geographical distribution of the trials as well as the endpoints assessed in the studies. […] ClinicalTrials.gov, World Health Organization International Clinical Trials Registry Platform, and PubMed were assessed till 11 May 2020. […] There are 134 different drug-based interventions being assessed in 463 clinical trials as treatment options China accounts for 35% of all ongoing clinical studies followed by USA 23% and other countries together account for 42%. […] Only 5.5% of the ongoing clinical trials are specifically designed to assess the most vulnerable population like elderly, patients with comorbidities and cancer. […] Multiple intervention-based clinical studies against severe acute respiratory syndrome-related coronavirus-2 are being performed throughout the world with a high concentration of clinical trials in the developed world with concern that of elderly and patients with comorbidities are being underrepresented and definite endpoints like mortality are being assessed in only one-fifth of the studies. | 2020-07-25 |
| 32706391 | Current literature and clinical guidelines do not include pregnant women as an a priori risk group for COVID-19. […] First, routinely test for SARS-CoV-2 infection in all pregnant women with clinical or epidemiological suspicion, regardless of gestational age or the clinical severity. | 2020-07-25 |
| 32706393 | Therefore, a systematic review was conducted to determine the positive detection rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in different clinical specimens using qRT-PCR. […] A total of 8136 pooled clinical specimens were analyzed to detect SARS-CoV-2, the majority were nasopharyngeal swabs (69.6%). | 2020-07-25 |
| 32706395 | The COVID-19 clinical spectrum varies from asymptomatic to death, and its complications may involve various organs. | 2020-07-25 |
| 32706396 | To systematically analyze the blood coagulation features of coronavirus disease 2019 (COVID-19) patients to provide a reference for clinical practice. | 2020-07-25 |
| 32706409 | Positive patients presented with a median of three symptoms (interquartile range, 1-3). […] Most common symptoms were fever (76%), dyspnea (35%), anosmia (29%) non-productive cough (27%), fatigue 22%), and ageusia (20%). | 2020-07-25 |
| 32706411 | The clinical manifestations of COVID-19 pose a series of challenges both in understanding and delimiting the disease secondary to the SARS-CoV-2 infection. […] Given that a complete understanding of its pathophysiology and clinical behavior has not yet been achieved, we wondered if coinfection with other respiratory viruses modifies its performance and outcomes described so far. […] The analysis showed us that there is a high variety both in the types of associated infections and in the clinical behavior of patients and their outcomes. | 2020-07-25 |
| 32706417 | Epidemiological characteristics, symptoms, blood test results and other data were recorded for all patients. | 2020-07-25 |
| 32706420 | Knowledge of the precise timing of SARS-CoV-2 infection may be of clinical and epidemiological relevance. […] Sera losing IgG reactivity after urea treatment (n = 28) were drawn significantly earlier (P = .04) after onset of symptoms than those which preserved it (n = 48). | 2020-07-25 |
| 32706426 | These findings are of great clinical value for timely and effective treatment of the COVID-19 cases. | 2020-07-25 |
| 32706510 | We evaluated the clinical course of eight COVID-19 patients, including their duration of viral shedding, by PCR testing of nasopharyngeal swabs. […] The average time from the onset of symptoms until the virus was no longer detectable was 31.6 ± 11.8 days (mean ± SD; range 17-53). […] Thus, it took 15.1 ± 14.7 (1-40) days from the time of clinical recovery for the virus to become undetectable. | 2020-07-25 |
| 32706616 | Telehealth is an important tool utilized to provide remote clinical care and has increased in prevalence during the coronavirus disease of 2019 (COVID-19) pandemic. | 2020-07-25 |
| 32706769 | Although classically causing cough, fever, and shortness of breath, increasing evidence suggests that manifestations of COVID-19 can be more subtle or masquerade as other clinical entities. […] This case report further emphasizes that COVID-19 may present with atypical symptoms. | 2020-07-25 |
| 32706819 | PGV, PCV and PTV were analyzed based on the time from the onset of initial symptoms in the common and severe groups. […] In the common group, PTV increased slowly and peaked at approximately 12 days from the onset of the initial symptoms. […] These features started to appear in Stage 2 (4-7 days from onset of initial symptoms) and were observed in all subsequent stages (p<0.05). | 2020-07-25 |
| 32706859 | GS-US-540-5807 is an ongoing real-world, retrospective cohort study of clinical outcomes in patients receiving standard-of-care treatment (non-remdesivir-cohort). […] The primary endpoint was the proportion of patients with recovery on day 14, dichotomized from a 7-point clinical status ordinal scale. | 2020-07-25 |
| 32706885 | Critical gerontological knowledge and skills needed in prison healthcare include awareness regarding the unusual clinical presentations of COVID-19 among older adults, deconditioning among older adults due to immobility, challenges in prognostication, and advance care planning with older adults. | 2020-07-25 |
| 32706953 | The primary outcome was clinical status at 15 days as assessed with the use of a seven-level ordinal scale (with levels ranging from one to seven and higher scores indicating a worse condition) in the modified intention-to-treat population (patients with a confirmed diagnosis of Covid-19). […] Among patients hospitalized with mild-to-moderate Covid-19, the use of hydroxychloroquine, alone or with azithromycin, did not improve clinical status at 15 days as compared with standard care. | 2020-07-25 |
| 32707089 | NAC elicited clinical improvement and markedly reduced CRP in all patients and ferritin in 9/10 patients. […] NAC mechanism of action may involve the blockade of viral infection and the ensuing cytokine storm that warrant follow-up confirmatory studies in the setting of controlled clinical trials. | 2020-07-25 |
| 32707096 | To examine the association between the use and timing of IFN-α2b and clinical outcomes, we analyzed in a retrospective multicenter cohort study of 446 COVID-19 patients in Hubei, China. […] We concluded that administration of IFN-α2b during the early stage of COVID-19 could induce favorable clinical responses. | 2020-07-25 |
| 32707160 | However, a number of ongoing clinical trials are investigating the efficacy and safety of the medicines which have already been registered and used for the treatment of other diseases, in the treatment of the coronavirus infection. […] Thus, the aim of this study was to review and evaluate the literature data on the toxicity of the selected individual drugs (ritonavir, lopinavir, remdesivir, chloroquine, and umifenovir) and the available clinical data concerning the possible adverse effects of the selected drug combinations (lopinavir/ritonavir + umifenovir, lopinavir/ritonavir + interferon β, chloroquine + remdesivir, and chloroquine + azithromycin). | 2020-07-25 |
| 32707218 | We used Fisher’s exact test and multivariable logistic regression methods to explore the risk factors associated with mental health problems (anxiety, depression, and PTSD symptoms associated with COVID-19 hospitalization). | 2020-07-25 |
| 32707264 | This pilot study aimed to evaluate the clinical efficacy of low-dose whole-lung radiation therapy in patients with COVID-19 pneumonia. […] In this clinical trial, conducted in Iran, we enrolled patients with COVID-19 who were older than 60 years and hospitalized to receive supplementary oxygen for their documented pneumonia. […] The clinical and paraclinical findings of 4 of the 5 patients (patient 4 worsened and died on day 3) improved on the first day of irradiation. | 2020-07-25 |
| 32707288 | We recommend practitioners to scrupulously screen this list of predicted drugs in order to authenticate those qualified for treating COVID-19 symptoms. | 2020-07-25 |
| 32707307 | Worldwide, clinical data remain the gold standard for disease surveillance and tracking. […] Wastewater surveillance - that is, monitoring disease via human effluent - represents a valuable complement to clinical approaches. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707411 | Neurological symptoms such as anosmia, altered mental status, headache, and myalgias may arise due to direct injury to the nervous system or by indirectly precipitating coagulopathies. | 2020-07-25 |
| 32707511 | Overall positivity rate for SARS-CoV-2-IgG was 81.1 % in outpatients (irrespective of sampling before or after day 21 after onset of symptoms) but significantly lower in asymptomatic contact persons (15.4 %, p < 0.0001). […] In contact persons without symptoms the ct values of the PCR assays were significantly higher (5-7 threshold cycles) than in outpatients, and ct values were significantly negative correlated to the SARS-CoV-2-IgG ratio, suggesting a lower viral load as a possible explanation for lower rate of seropositivity. | 2020-07-25 |
| 32707573 | Here we profiled a library of drugs encompassing approximately 12,000 clinical-stage or Food and Drug Administration (FDA)-approved small molecules to identify candidate therapeutic drugs for COVID-19. […] Since most of the molecules identified in this study have already advanced into the clinic, their known pharmacological and human safety profiles will enable accelerated preclinical and clinical evaluation of these drugs for the treatment of COVID-19. | 2020-07-25 |
| 32707661 | This raises the hypothesis that the ELA-induced pro-inflammatory and senescent phenotype may play a role in determining the clinical course of COVID-19, and the convergence of ELA-induced senescence and COVID-19 induced exhaustion represents the worst-case scenario with the least effective T-cell response. | 2020-07-26 |
| 32707833 | Vaccination trials require precise clinical management, complemented with detailed evaluation of safety and immune responses. | 2020-07-26 |
| 32707942 | Analyses of the clinical trials were grouped as chemotherapy, serotherapy, anticoagulant, and the use of human recombinant soluble ACE2 therapies. | 2020-07-26 |
| 32707965 | To date, 38 cases have been reported, with other cases most likely undiagnosed mainly due to a lack of clinical awareness and diagnostic screening. | 2020-07-26 |
| 32708007 | Common symptoms of COVID-19 pneumonia include fever, fatigue, and dry cough. | 2020-07-26 |
| 32708112 | Coronaviruses are positive sense single-stranded RNA viruses that infect several animal species, causing symptoms that range from those similar to the common cold to severe respiratory syndrome. […] Furthermore, clinical trials are currently evaluating the safety and efficacy of anti-inflammatory drugs, such as tocilizumab. | 2020-07-26 |
| 32708205 | Primary outcome of interest was the severity of patients’ clinical courses. […] At inclusion, 12 patients had mild clinical status, 25 moderate clinical status and 7 severe clinical status. […] In univariate analyses, aldosterone and C-reactive protein (CRP) levels at inclusion were significantly higher in patients with severe clinical course as compared to those with mild or moderate course (p < 0.01 and p = 0.03, respectively). […] Both plasmatic aldosterone and CRP levels at inclusion are associated with the clinical course of Covid-19. | 2020-07-26 |
| 32708264 | The purpose of this study was to identify biological factors (particularly leukocyte subtypes and inflammatory markers) associated with a risk of clinical deterioration (i.e., orotracheal intubation (OTI)) and to determine whether CH was likely to influence clinical and biological behavior in patients with severe COVID-19 requiring hospitalization. […] Here, we describe clinical and biological features, including the screening of CHIP mutants in a well-annotated cohort of 122 hospitalized patients with a laboratory-confirmed diagnosis of COVID-19 (55% requiring OTI). […] However, the existence of CH did not significantly impact clinical outcome, including OTI or death, and did not correlate with other laboratory findings. | 2020-07-26 |
| 32708322 | Importantly, the safety of EGCG/green tea extract supplementation is well documented in many clinical trials, as discussed in this review. | 2020-07-26 |
| 32708357 | Demographic and clinical data including clinical management were collected and subjected to a multivariable analysis; primary outcome was mortality. | 2020-07-26 |
| 32708430 | There are a number of medications that have been tried with some showing early clinical promise. | 2020-07-26 |
| 32708449 | Advance Serious Illness Preparations and Planning (ASIPP) consists of discrete steps using evidence-based tools to prepare people for future clinical decision-making in the context of shared decision-making and informed consent. | 2020-07-26 |
| 32708504 | Certain clinical and biological characteristics determine high-risk phenotypes within the DM population and such prognostic markers need to be characterized in future studies. | 2020-07-26 |
| 32708525 | This study represents a starting point or hint for future scientific-clinical investigations and suggests a range of possible protein targets of autoimmunity in SARS-CoV-2 infection. | 2020-07-26 |
| 32708578 | Drawing on evidence from literature that demonstrates the reduced levels of GSH in the main conditions clinically associated with severe disease, we highlight the relevance of restoring GSH levels in the attempt to protect the most vulnerable subjects from severe symptoms of COVID-19. | 2020-07-26 |
| 32708750 | The clinical and analytical spectrum and treatment responses and mortality are poorly characterized. […] Clinical and analytical features, chest X-ray, polymerase chain reaction (PCR) and antibodies for SARS-CoV-2, treatment and outcomes were analyzed in 48 patients diagnosed with COVID-19 during March and April 2020 in two coordinated Spanish hemodialysis units. […] In 200 haemodialysis patients, COVID-19 was diagnosed in 48, of whom 22 were PCR positive, eight PCR negative but seroconverted and two were diagnosed on typical clinical grounds. | 2020-07-26 |
| 32708858 | However, there is a paucity of data regarding the clinical course and the therapeutic management of patients with chronic kidney disease and COVID-19 infection. | 2020-07-26 |
| 32708870 | Quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) is currently used for the clinical diagnosis of SARS-CoV-2 infection using nasopharyngeal swabs, tracheal aspirates, or bronchoalveolar lavage (BAL) samples. | 2020-07-26 |
| 32709002 | We aimed to analyze baseline socio-demographic and clinical factors associated with an increased likelihood of mortality in men and women with coronavirus disease (COVID-19). […] We described the socio-demographic and clinical characteristics of all patients of the cohort. […] Age-adjusted logistic regressions models were performed to analyze the likelihood of mortality based on demographic and clinical variables. | 2020-07-26 |
| 32709193 | Recently, severe neurological manifestations such as acute disseminated encephalomyelitis, which may be not linked to lung pathology, have been identified in COVID-19, contributing thus further to the versatility of its clinical features. | 2020-07-26 |
| 32709280 | We studied the clinical characteristics and therapies of severe cases in Jiangsu Province. […] A multicenter retrospective cohort study was conducted to analyze clinical, laboratory data and treatment of 60 severe cases with COVID-19 infection in Jiangsu Province between January 24, 2020 and April 20, 2020. | 2020-07-26 |
| 32709413 | Telephone interviews were used to administer a clinical questionnaire to patients, and e-mail was used to receive the results of diagnostic tests conducted in outpatient settings. | 2020-07-26 |
| 32709462 | Here, we review what is currently known about the effects of the virus and its clinical condition, Covid-19 in areas of relevance to those providing care to neonates. […] The clinical description of 26 neonates <30 days of age showed no deaths and only one requiring intensive care. | 2020-07-26 |
| 32709482 | Data collection included clinical presentation, laboratory and radiological findings, treatment and outcome. […] Patients who died were older than survivors, had a longer time from transplant and a worse clinical presentation at diagnosis. | 2020-07-26 |
| 32709495 | However, the pandemic presents a significant barrier and efforts should be made to ensure equitable access to clinical trials and prospective data collection to elucidate the outcomes of COVID-19 in this population. | 2020-07-26 |
| 32709505 | Online questionnaires were conducted, and these included demographic information, clinical features, and 4 patient-reported outcome scales (Generalized Anxiety Disorder Questionnaire [GAD-7], Patient Health Questionnaire [PHQ-9], Insomnia Severity Index [ISI], and Impact of Events Scale-Revised [IES-R]). | 2020-07-26 |
| 32709637 | This retrospective cohort study aims to define the clinical findings and outcomes of every patient admitted to a district general hospital in Surrey with COVID-19 in March 2020, providing a snapshot of the first wave of infection in the UK. […] Clinical Frailty Scale (CFS) was higher in patients over 65 who died than in survivors (median 5, IQR 4-6 vs 3.5, IQR 2-5; p<0.01). | 2020-07-26 |
| 32709734 | Methods: Review of clinical examination, CT, PET, MRI imaging, and autoantibodies testing. […] Results: The patient presented subacute cerebellar syndrome and myoclonus several days after general infectious symptoms. […] Treatment with steroids allowed a rapid improvement of symptoms. […] Conclusion: This clinical case brings arguments on the possible relationship between SARS-CoV-2 infection and autoimmune encephalitis, and on the interest of 18F-FDG-PET in such context. | 2020-07-26 |
| 32709772 | To find the clinical profile and prevalence of conjunctivitis and other ocular manifestations in mild COVID-19 positive patients in a nodal COVID-19 hospital. […] Forty-eight (37.80%) patients had upper respiratory tract symptoms, 20 (15.75%) patients had systemic illness, 18 (14.17%) patients were using spectacles, and 50 (39.37%) patients had history of hand-eye contact. […] Three (3/8) patients had developed conjunctival congestion even before the manifestation of definite COVID-19 symptoms. […] Five patients (5/8) patients had no other associated ocular symptoms other than congestion. […] Six patients (6/8) had symptoms of upper respiratory tract infection. | 2020-07-26 |
| 32710056 | Issues were identified with clinical diagnosis from sectional panoramic radiographs, which led to the introduction of extraoral bitewings being taken as an alternative. | 2020-07-26 |
| 32710064 | Results A total of 120 surveys were completed; 53.3% of respondents displayed symptoms of generalised anxiety. | 2020-07-26 |
| 32710161 | In addition to the knowledge that can be gained from the rapid performance of clinical trials, the treatment is therefore based on analogies to other syndromes, such as sepsis and macrophage activation syndrome. | 2020-07-26 |
| 32710198 | The practice setting of participating rheumatologists included University Teaching Hospitals that are the main rheumatology and clinical immunology service providers for adults and children RD patients. […] Twenty-three recommended decrease/avoid NSAIDs if the RD patient had confirmed COVID-19 or symptoms. | 2020-07-26 |
| 32710297 | In order to outline a standard/baseline model of care, we think that it can be useful to refer to already existing rehabilitative plans with a long-standing tradition in Italy, such as those ones prescribed for work-related respiratory diseases like pneumoconiosis, in which long-term outcomes share some clinical characteristics with post-infective lung fibrosis. | 2020-07-26 |
| 32710481 | Among the population, healthcare professionals who treat COVID-19 patients are most likely to develop psychological distress and posttraumatic stress symptoms (PTSS). […] Participants were asked to provide sociodemographic and clinical information, and to complete: (a) quality of life and health-related Visual Analogue Scales, (b) State-Trait Anxiety Inventory-Form Y1, (c) Beck Depression Inventory, and (d) PTSD Checklist for DSM-5. […] A comparison between healthcare professionals working in COVID-19 wards and other units revealed that the former reported higher levels of both depressive symptoms and PTSS. […] Moreover, the results of regression analyses showed that in healthcare professionals working with COVID-19 patients, gender and marital status, and gender and age significantly predicted depressive symptoms and PTSS, respectively. […] Particularly, being female and not in a relationship were found to be associated with higher levels of depressive symptoms, whereas being female and older were found to be related to higher levels of PTSS. […] The current findings suggest that specific predisposing factors could identify healthcare workers who are at high risk of developing mental health symptoms when faced with COVID-19 patients. | 2020-07-26 |
| 32710500 | Clinical characteristics and outcomes were compared to a matched control group of 53 non-cancer patients with COVID-19. | 2020-07-26 |
| 32710536 | Multiple linear regression analysis showed that age, job position, availability of protective materials, signs of suspected symptoms, and susceptibility to emotions and behaviors of people around them were identified as risk factors for anxiety, whereas psychological resilience was identified as a protective factor. | 2020-07-26 |
| 32710571 | Molecular diagnostics is a rapidly growing branch of the clinical laboratory and has accelerated the advance of personalized medicine in the fields of pharmacogenomics, pharmacogenetics, and nutrigenomics. | 2020-07-26 |
| 32710575 | This review assesses the evidence gathered so far and highlights the research that needs to be done to help inform clinical decision making. | 2020-07-26 |
| 32710599 | In the clinical symptoms of Behçet’s disease, many immunosuppressive and immunomodulatory drugs are used. | 2020-07-26 |
| 32710613 | We describe the epidemiological and clinical features of children with MIS-C in Spain. | 2020-07-26 |
| 32710639 | The purpose of this study was to evaluate the clinical features of mild-to-moderate coronavirus disease 2019 (COVID-19) in a sample of Italian patients and to investigate the occurrence of smell and taste disorders. […] Infected individuals with suspected (clinical diagnosis) or laboratory-confirmed COVID-19 infection were recruited. […] Patients completed a survey-based questionnaire with the aim of assessing their epidemiological and clinical characteristics, general otorhinolaryngological symptoms, and smell and taste disorders. […] The most prevalent general symptoms included fever, myalgia, cough, and headache. […] Smell disorders occurred before the other symptoms in 11.6% of patients and was not significantly associated with nasal obstruction or rhinorrhea. […] Interestingly, our statistical analysis did not show any significant difference, either for general symptoms or otorhinolaryngological features, between the clinical diagnosis group and the laboratory-confirmed diagnosis (polymerase chain reaction) group. […] The structural equation model confirmed significant standardized paths (P < .05) between general symptoms, comorbidities, and general otorhinolaryngological complaints in the absence of a significant correlation between these elements and smell and taste alterations. […] The prevalence of smell and taste disorders in mild-to-moderate Italian COVID-19 patients is significant both in suspected and laboratory-confirmed cases and reveals a strong correlation between these clinical signs regardless of the presence of general or otorhinolaryngological symptoms, such as nasal obstruction or rhinorrhea. | 2020-07-26 |
| 32710646 | Baseline clinical characteristics and admission laboratory variables were retrospectively collected. […] Prevalence of clinical co-morbidities and laboratory abnormalities were compared between groups using descriptive statistics. | 2020-07-26 |
| 32710647 | In the control group, 1589 individuals without clinical symptoms (cough, fever, and fatigue) and returning from outside Shenzhen were enrolled. […] Strong supplemental support for clinical information can be provided by antibody detection, especially for IgA. | 2020-07-26 |
| 32710669 | Serology testing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is increasingly being used during the current pandemic of coronavirus disease 2019 (COVID-19), although its clinical and epidemiologic utilities are still debatable. […] These findings demonstrated high sensitivity and specificity of appropriately validated SARS-CoV-2 serologic assays with implications for clinical use and epidemiological seroprevalence studies. | 2020-07-26 |
| 32710674 | Two data sets including demographic/clinical characteristics (comorbidities and cardiovascular medications use) and laboratory PCR codes for COVID-19 were linked to construct an anonymized research database. | 2020-07-26 |
| 32710732 | Infected people had shown symptoms resembling pneumonia, but about 50% of patients were asymptomatic. | 2020-07-26 |
| 32710733 | The review showed that AKI patients, who were susceptible to a cytokine storm, showed clinical deterioration. […] The research team concluded that the dysregulation of the cholinergic anti-inflammatory system could explain most of the clinical features of severe COVID-19. | 2020-07-26 |
| 32710735 | The objective of this report was to describe the clinical case of a patient infected by SARS-CoV-2 who developed acute renal injury, probably secondary to this infection. | 2020-07-26 |
| 32710910 | We describe 2 adolescents with cholestasis and hepatitis with mild presentation of severe acute respiratory syndrome-coronavirus 2 lacking typical symptoms. | 2020-07-26 |
| 32710937 | The clinical respiratory symptoms include dry cough, fever, anosmia, breathing difficulties, and subsequent respiratory failure. […] The deficiency of most nutrients increases the individual susceptibility to virus infection with a tendency for severe clinical presentation. | 2020-07-26 |
| 32710969 | In most cases, and due to the urgency imposed by the number and severity of the patients’ clinical conditions, the choice of treatment has been limited to repurposed drugs, approved for other indications, or investigational agents used for other viral infections often rendered available on a compassionate-use basis. […] In several months, an exceptionally large number of clinical trials have been designed to evaluate the safety and efficacy of anti-COVID-19 therapies in different clinical settings (treatment or pre- and post-exposure prophylaxis) and levels of disease severity, but only few of them have been completed so far. […] This review focuses on the molecular mechanisms of action that have provided the scientific rationale for the empirical use and evaluation in clinical trials of structurally different and often functionally unrelated drugs during the SARS-CoV-2 pandemic. | 2020-07-26 |
| 32710975 | This mortality risk model allows early risk stratification of hospitalized patients with COVID-19 before the appearance of obvious signs of clinical deterioration, and it can be used as a tool to guide clinical decision making. | 2020-07-26 |
| 32711003 | Some studies suggest that there were no significant differences in symptoms between patients who suffered from both diabetes and COVID-19 and those who only suffered COVID-19. […] These clients have poor ARDS prognosis, severe symptoms, and the death rate is higher among COVID-19 patients. | 2020-07-26 |
| 32711057 | The aim was to determine whether various clinical specimens obtained from COVID-19 patients contain the infectious virus. […] To demonstrate whether various clinical specimens contain the viable virus, we collected naso/oropharyngeal swabs and saliva, urine and stool samples from five COVID-19 patients and performed a quantitative polymerase chain reaction (qPCR) to assess viral load. […] SARS-CoV-2 RNA was detected in all naso/oropharyngeal swabs and saliva, urine and stool samples collected between days 8 and 30 of the clinical course. […] Viable SARS-CoV-2 was demonstrated in saliva, urine and stool samples from COVID-19 patients up to days 11-15 of the clinical course. […] This result suggests that viable SARS-CoV-2 can be secreted in various clinical samples and respiratory specimens. | 2020-07-26 |
| 32711111 | Hundreds of clinical trials on existing approved drugs from different classes acting on a multitude of targets in the virus life cycle are ongoing to examine potential effectiveness for the prevention and treatment of the infection. | 2020-07-26 |
| 32711256 | In this study, we provide a coherent overview of the duration of viral detection and viral RNA load in COVID-19 patients, stratified by specimen type, clinical severity, and age. […] Our analysis showed consistent viral detection from specimen from the upper respiratory tract (URT), the lower respiratory tract (LRT), and faeces, irrespective of the clinical severity of COVID-19. […] This review may aid mathematical modelling and help in defining appropriate endpoints for clinical trails with antivirals in COVID-19. | 2020-07-26 |
| 32711297 | We describe the clinical and immunological evolution of two MS patients under alemtuzumab treatment who were affected by COVID-19, one of them only one week after receiving her last dose, and both recovered without sequelae. | 2020-07-26 |
| 32711687 | We recorded demographics, neonatal, and maternal clinical presentation, as well as infection control practices in the hospital and at home. […] None of the neonates had symptoms of COVID-19. | 2020-07-27 |
| 32711692 | These management strategies should focus on risk stratification, suitable clinical monitoring, low-threshold access to diagnostics, and decision making about removal from and return to work. | 2020-07-27 |
| 32711871 | To conduct a systematic review of original peer-reviewed studies, containing data on the identification of SARS-CoV-2 in clinical samples of amniotic fluid, placenta or membranes, umbilical cord blood, and human milk, from women with a clinically or confirmed diagnosis of COVID-19. […] Seventeen studies were included, in which 143 clinical samples were identified (38 of amniotic fluid; 34 of placentas or membranes; 39 from umbilical cord blood and 32 from human milk). […] Following our search criteria, we found no studies that demonstrate the detection of SARS-CoV-2, in conjunction with viral isolation and the evaluation of the infective capacity of viral particles, in clinical samples of amniotic fluid, placenta or membranes, umbilical cord blood and human milk, from women with a confirmed or clinical diagnosis of COVID-19. | 2020-07-27 |
| 32711925 | NRF2 activators such as sulforaphane and bardoxolone methyl are already in clinical trials. […] The safety and efficacy information of these modulators in humans, together with their well-documented cytoprotective and anti-inflammatory effects in preclinical models, highlight the potential of this armamentarium for deployment to the battlefield against COVID-19. | 2020-07-27 |
| 32711946 | Diagnostic accuracy was highlighted as a concern for both clinicians and patients due to inherent inability to conduct a traditional clinical examination, notable in 43.5% of qualitative comments. […] Although ‘in-person’ clinical appointments will continue to be regarded as the default safe and gold standard management modality, OMFS departments should consider significant upscaling of teleconsultation services. | 2020-07-27 |
| 32712069 | The psychological health status of frontline health care professionals during the 2019 novel coronavirus outbreak warrants clinical attention. | 2020-07-27 |
| 32712116 | Secondary endpoints comprised presenting symptoms, diagnosis, prescriptions, adverse effects, and progression of monthly consulting turnover. […] The three most frequent symptoms (48.5% of cases) were otalgia, hearing impairment, and vertigo. | 2020-07-27 |
| 32712122 | The objective of this study is to explore the association between documented diabetes, fasting plasma glucose (FPG), and the clinical outcomes of Coronavirus disease 2019 (COVID-19). […] Demographic, clinical, treatment, and laboratory data were collected and compared between ICU and non-ICU patients. […] Multivariable logistic regression models were used to explore the risk factors associated with poor clinical outcomes (ICU admission or death). […] There were significant changes in several clinical parameters in ICU patients (leukopenia, lymphopenia, elevated D-dimer, as well as higher levels of FPG, cardiac troponin, serum ferritin, IL-6, and high-sensitivity C-reactive protein)compared with non-ICU patients. […] Hyperglycemia and a history of diabetes on admission predicted poor clinical outcomes in COVID-19. | 2020-07-27 |
| 32712124 | The objective of this research report was to delineate the clinical characteristics with COVID-19 infection with RAS and to consider its significance not just for the search of novel antiviral drugs, but for the management and prevention of death of patients with COVID-19. […] It was a retrospective case series analysis of demographic and clinical data with associated comorbidities of 206 deaths reported in India up to 10th April 2020. | 2020-07-27 |
| 32712222 | VAT is a marker of worse clinical outcomes in patients with COVID-19. | 2020-07-27 |
| 32712235 | Chest tubes were inserted, with immediate clinical improvement. | 2020-07-27 |
| 32712272 | It appears that this NO synthase (NOS)-independent mechanism has been overlooked in the current developing of clinical treatments. | 2020-07-27 |
| 32712300 | In this review, we summarize preclinical and clinical studies to investigate whether the use of ACEIs/ARBs increases ACE2 expression in animals or patients. | 2020-07-27 |
| 32712332 | The clinical characteristics of 305 COVID-19 patients were analysed and were compared between the survivor and non-survivor groups. | 2020-07-27 |
| 32712334 | All patients received supportive care as well as regular laboratory and clinical monitoring. […] Baseline laboratory and clinical characteristics were similar between the two groups. | 2020-07-27 |
| 32712376 | Clinical and epilepsy-related details of telephonic consultations for children 1 month-18 years, performed between 26th March and 17th May 2020 in a tertiary care teaching hospital in Uttarakhand (a state of India known for hilly terrains with low per capita income) were recorded. […] Voice call, text message, picture/video message, and all other possible measures were employed to accumulate maximum clinical information in real-time. […] Hundred-thirteen children were identified to have a total of 152 significant clinical events (breakthrough seizure/uncontrolled epilepsy (108), AED related (13), and unrelated systemic adverse effects (24), worsening of associated co-morbidities (7). […] In rest of the patients, the query of the caregiver included unavailability of AED/prescribed commercial brand in the locality, query related to the dose of drugs, proxy for a scheduled routine visit (no active issues), and concern regarding COVID-19 related symptoms and effect of COVID-19 and lockdown in children with epilepsy. | 2020-07-27 |
| 32712426 | Within 72 hours of starting symptoms, she was neurologically asymptomatic. | 2020-07-27 |
| 32712565 | The variables included were demographic and baseline clinical characteristics (age, gender, living situation, occupational status, type of epilepsy, duration of epilepsy, number of antiepileptic medications (AEDs), presence of known psychiatric illness, and use of psychiatric medications), their seizure control in the month prior to the pandemic, perceived stress during this period of time, sleep changes, compliance changes, and change in seizure control during the pandemic. | 2020-07-27 |
| 32712582 | Assigning patients to preset ventilators based on their required level of support on the lower PEEP/higher [Formula: see text] scale of the National Institute of Health’s National Heart, Lung, and Blood Institute ARDS Clinical Network (ARDSNet), secondary to lung mechanics, could be used to overcome some of the legitimate concerns of placing multiple patients on a single ventilator. […] We emphasize that our results are currently based on a computational model that has not been validated against any preclinical or clinical data. | 2020-07-27 |
| 32712607 | We assessed the incidence and clinical characteristics of AKI in patients with laboratory-confirmed COVID-19 and its effects on clinical outcomes. […] AKI was defined according to the KDIGO clinical practice guidelines. | 2020-07-27 |
| 32712629 | The host immune response to SARS-CoV-2 appears to play a critical role in disease pathogenesis and clinical manifestations. […] Therefore, mechanisms underlying immune abnormalities in patients with COVID-19 must be elucidated to guide clinical management of the disease. […] In this review, we discuss the immunopathology of COVID-19, its potential mechanisms, and clinical implications to aid the development of new therapeutic strategies against COVID-19. | 2020-07-27 |
| 32712670 | Our findings provide mechanistic insight with direct clinical implications, rationalizing why the highest adverse birth outcomes are reported in HIV-positive pregnancies exposed to lopinavir-cART from conception. […] Our results highlight the need for reconsidering current guidelines recommending lopinavir use in pregnancy and indicate that lopinavir should be avoided especially in the first trimester, whereas darunavir is safe to use and should be the preferred PI in pregnancy.Further, in current times of the COVID-19 pandemic, lopinavir is among the top drug candidates which are being repurposed for inclusion in clinical trials world-over, to assess their therapeutic potential against the dangerous respiratory disease. | 2020-07-27 |
| 32712702 | FDG PET/CT was performed from day 6 to day 14 of the onset of symptoms. […] FDG PET/CT data were compared with chest CT evolution and short-term clinical outcome. […] There was no correlation between PET lung inflammatory status and chest CT evolution or short-term clinical outcome. | 2020-07-27 |
| 32712704 | The neuraxial anesthesia may have little adverse influence on clinical outcomes in patients with COVID-19 after reviewing previous case reports. | 2020-07-27 |
| 32712743 | Rheumatology service had to be reorganised with a cancellation of elective clinics and clinical reconfiguration to continue to deliver care to patients, support frontline, and prevent viral transmission. […] • To ensure wider access to innovative digital technology in clinical practice; implement telephone and video consultations where appropriate. | 2020-07-27 |
| 32712878 | Published data and multidisciplinary clinical judgement were used to assign risk scores based on patient and tumor factors, length of delay, and tumor response to preoperative therapy. | 2020-07-27 |
| 32713047 | Participants provided 1,213 statements about perceived supports required to provide quality clinical care. | 2020-07-27 |
| 32713060 | Of the 37 patients included in the study, 56.7% of patients were asymptomatic or had mild disease and 27% presented with severe symptoms. […] Though the overall clinical presentation and outcomes of this cohort from a limited resource setting mimic the global scenario, unique social and logistic issues are an additional burden to the patient, caregivers and the health-care facilities, which may worsen the outcomes in the future as the pandemic continues to spread. | 2020-07-27 |
| 32713118 | Clinical features and survival of patients with and without liver injury were compared. | 2020-07-27 |
| 32713123 | The present case should provide awareness that extrapulmonary symptoms in COVID-19 may be attributable to viral infiltration of diverse organs. | 2020-07-27 |
| 32713161 | Remarkably, in addition to the respiratory symptoms, some COVID-19 patients also suffer from cardiovascular injuries. | 2020-07-27 |
| 32713239 | The evolving understanding of the relationship between comorbid disease and clinical outcomes among this population is assessed. | 2020-07-28 |
| 32713251 | In this article, we discuss currently available information with COVID-19-related neurological complications, possible routes of virus infection into the central nervous system, and hypothesis about virus-induced cytokine storm syndrome, long-term outcomes, as well as ongoing clinical studies of novel therapies and biomarkers for COVID-19. | 2020-07-28 |
| 32713370 | For the asymptomatic or mild symptomatic patients with COVID-19, the actual aggravation of disease may be more advanced than the clinical appearances. […] This study provided a new approach to improve the clinical management plan and prognosis of COVID-19. | 2020-07-28 |
| 32713371 | Hence, we calculated cumulative CFR (cCFR) using only patients whose final clinical outcomes were known at a certain time point. | 2020-07-28 |
| 32713374 | Using information from South London and Maudsley NHS Foundation Trust (SLAM) clinical records, via the Clinical Record Interactive Search system, we identified 6309 individuals who had an ICD-10 diagnosis of schizophrenia-spectrum disorders and were taking antipsychotics at the time of the COVID-19 pandemic onset in the UK. […] Individuals who were on clozapine had increased risk of COVID-19 infection compared with those who were on other antipsychotic medication (unadjusted hazard ratio HR = 2.62, 95% CI 1.73-3.96), which was attenuated after adjusting for potential confounders, including clinical contact (adjusted HR = 1.76, 95% CI 1.14-2.72). […] Potential clinical implications are discussed. | 2020-07-28 |
| 32713618 | In doing so we present a scanning protocol for lung POCUS in COVID-19 that maximizes clinical utility and provider safety. […] Lung POCUS can offer valuable clinical data when evaluating patients with COVID-19. […] Scanning protocols such as that presented here, which target clinical utility and decreased nosocomial disease spread, must be prioritized. | 2020-07-28 |
| 32713658 | We aimed to evaluate how the corona virus disease of 2019 (COVID-19) outbreak influenced emergency department (ED) admissions for urolithiasis, hospitalizations and clinical management of the hospitalized patients. […] Patients admitted to ED had more complications, more frequently need hospitalization and regarding clinical management early stone removal was preferred over urinary drainage only. | 2020-07-28 |
| 32713663 | Clinical records of all participants were examined to obtain information regarding age, sex, mechanism of injury, and diagnosis. […] In the no-COVID and COVID periods, 6 patients (M: 5, F: 1; mean age 42 years, range 21-64) and 2 patients (M: 1, F: 1; mean age 29.5 years, range 24-35) reported having a feeling of momentary post-traumatic shoulder instability, and 0 and 1 patients (M: 1, F: 0; age 56 years), respectively, reported similar symptoms at the elbow. | 2020-07-28 |
| 32713730 | To assess the risk of clinical complications in pregnant women and neonates infected with SARS-CoV-2 carrying out a systematic review and meta-analysis of observational studies. […] Only observational studies focused on the assessment of clinical outcomes associated with pregnancy in COVID-19 women were selected. […] The mean (SD) duration from the first symptoms to the hospital admission and to labour were 5.5 (2.0) and 9.5 (8.7) days, respectively. | 2020-07-28 |
| 32713754 | To determine the relationship between the amount and intensity of physical activity performed by older adults in North America (United States and Canada) and their depression and anxiety symptoms while currently under social distancing guidelines (SDG) for the COVID-19 pandemic. […] Participants completed the Physical Activity Scale for the Elderly, to determine the amount and intensity of physical activity performed, as well as both the Geriatric Depression Scale and Geriatric Anxiety Scale, to ascertain the extent of their depression and anxiety-like symptoms. […] Participants who performed greater levels of physical activity experienced lower levels of depression-like symptoms when age, sex, and education were accounted for; however, no relationship between physical activity and anxiety-like symptoms was found. […] A hierarchical regression analysis that incorporated the intensity of physical activity performed (light, moderate, and vigorous) in the model indicated that greater light and strenuous activity, but not moderate, predicted lower depression-like symptoms. | 2020-07-28 |
| 32713774 | During the ongoing pandemic, eye care practitioners should reinforce CL patient education to minimize the risk of SARS-CoV-2 infection and CL-related complications requiring clinical care. | 2020-07-28 |
| 32713780 | We therefore hypothesize that improving oral health could decrease the severity of COVID-19 symptoms and reduce the associated morbidity. | 2020-07-28 |
| 32713784 | We identified 3 indirect pre-clinical studies and 28 clinical studies including 5776 patients with COVID-19 (13 with a comparison group, 15 single-arm). […] There is insufficient evidence regarding the clinical efficacy and safety of tocilizumab in patients with COVID-19. […] Its use should be considered experimental, requiring ethical approval and clinical trial oversight. | 2020-07-28 |
| 32713863 | The world is currently facing the COVID-19 pandemic, for which mild symptoms include fever and dry cough. | 2020-07-28 |
| 32714080 | Decision curve analysis (DCA) was used to test the clinical value of the proposed model. […] The radiomics model seems to be the most practical one for possible clinical use. | 2020-07-28 |
| 32714688 | A typical symptom includes cough and fever, but a considerable number of patients can manifest gastrointestinal (GI) symptoms, including diarrhea, which can be the initial presentations and may or may not present with respiratory symptoms or fever. […] We reviewed the mechanisms, clinical manifestation, impact on pre-existing liver diseases, and recommendations endorsed by the several GI societies for the management and prevention of its transmission. | 2020-07-28 |
| 32714714 | No physicians or medical staff developed COVID-19 symptoms. | 2020-07-28 |
| 32714821 | Currently, the gold standard for test is Reverse Transcriptase Polymerase Chain Reaction (RT-PCR); however, patients with a high clinical suspicion for COVID-19 can sometimes have multiple negative tests. | 2020-07-28 |
| 32714873 | Responses were analyzed in relation to responders’ age, sex, and clinical status (advanced/metastatic disease undergoing systemic treatment vs. stable metastatic thyroid cancer in active surveillance vs. low-risk thyroid cancers with no evidence of structural disease during standard follow-up). […] No differences emerged across clinical status groups. | 2020-07-28 |
| 32714874 | We further review the evolving clinical evidence behind these approaches and predict that they will continue to be used in routine practice even long after the pandemic, particularly for patients with durable disease control. | 2020-07-28 |
| 32714890 | Contemporary health challenges require a public health approach, in addition to clinical skills, for physicians to provide equitable care. | 2020-07-28 |
| 32715050 | We report on data and debriefing observations in the context of an immersive simulation conducted to (a) train clinicians and (b) test new protocols and kits, developed in table-top exercises without prior clinical experience to fit anticipated clinical encounters in the setting of the rapidly expanding COVID-19 pandemic. […] We began to summarize, interpret, critique, and discuss our data and debriefing observations in a rapid co-publication in the Journal of Clinical Anesthesia. | 2020-07-28 |
| 32715280 | The COVID-19 pandemic has been met with studies on risk factors, characteristics, and clinical course. […] Among these characteristics are neurologic symptoms, which may provide improved insight into the mechanisms of this novel virus and the brain’s susceptibility to infectious diseases. | 2020-07-28 |
| 32715315 | In this study, we present a viral-associated disease-specific chemogenomics knowledgebase (Virus-CKB) and apply our computational systems pharmacology-target mapping to rapidly predict the FDA-approved drugs which can quickly progress into clinical trials to meet the urgent demand of the COVID-19 outbreak. | 2020-07-28 |
| 32715376 | There are limited data about the clinical course of end-stage renal disease (ESRD) patients infected with COVID-19. […] Her clinical course resembles case 1. | 2020-07-28 |
| 32715448 | Furthermore, we examine how various layers of modern wound closure compare to conventional methods while discussing both the clinical and economic impacts of each. | 2020-07-28 |
| 32715498 | Studies that examined pneumonia complications in patients who had taken NSAIDs before onset of symptoms were identified. | 2020-07-28 |
| 32715660 | Data were also collected from asymptomatic patients and those with COVID-19-like symptoms who tested negative or were not tested. […] A total of 226 SLE patients were included: 41 patients with confirmed COVID-19; 19 patients who tested negative for COVID-19; 42 patients with COVID-19-like symptoms who did not get tested; and 124 patients who remained asymptomatic without testing. | 2020-07-28 |
| 32715661 | Pre-clinical data support pentoxifylline as effective in cytokine-driven lung damage. […] Clinical studies of pentoxifylline in radiation and cytokine-induced lung damage in humans are positive and consistent with anti-inflammatory efficacy. | 2020-07-28 |
| 32715672 | Among them, only one had a polymerase chain reaction (PCR)-confirmed case among their close contacts and 13 did not experience COVID-19-related symptoms. | 2020-07-28 |
| 32715776 | Deescalation of systemic and radiation therapy can be utilized safely in selected clinical scenarios. | 2020-07-28 |
| 32715804 | Management of acute respiratory distress syndrome (ARDS) in pregnant women infected with new severe acute respiratory syndrome Corona virus 2 (SARS-CoV2) is a challenging clinical task. […] Given the persistent hypoxemia despite oxygen therapy via non rebreather face mask (FiO2:80%), convalescent plasma transfusion was administered that led to a mild clinical improvement as well as decrease in inflammatory markers. | 2020-07-28 |
| 32716033 | Such innovation is essential for solving persistent scientific, public health, and clinical challenges underlying current and emerging health disparities. | 2020-07-28 |
| 32716038 | Digital and community-based interventions are being increasingly relied upon to address these health impacts and bridge the gap in health care access despite insufficient research of these interventions as a replacement for, not an adjunct to, in-person clinical care. | 2020-07-28 |
| 32716073 | Decision tree analysis by combining vitamin D levels and clinical features was applied to predict severity in COVID-19 patients. | 2020-07-28 |
| 32716217 | Comorbidities are commonly seen in patients with coronavirus disease 2019 (COVID-19), but the clinical implication is not yet well-delineated. […] We aim to characterize the prevalence and clinical implications of comorbidities in patients with COVID-19. | 2020-07-28 |
| 32716553 | A total of 961 hospitalized COVID-19 patients with a definite clinical outcome (death or discharge) were retrospectively enrolled. […] Demographic and clinical information were extracted from the medical records. | 2020-07-28 |
| 32716579 | This review examined how applicable national and regional clinical practice guidelines and recommendations for managing neonates born to mothers with COVID-19 mothers were to the evolving pandemic. […] It is important that transmission risks are not increased when new information is incorporated into clinical recommendations. | 2020-07-28 |
| 32716826 | Stroke centers have multidisciplinary clinical and procedural expertise to support COVID treatment teams. | 2020-07-28 |
| 32716836 | Very little is known about how anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis modifies the susceptibility, clinical presentation and disease course of COVID-19. | 2020-07-28 |
| 32716892 | Although offline visits are essential for patients with severe conditions, IHDD can help to relieve pressure on hospitals by reducing an influx of patients with mild symptoms. | 2020-07-28 |
| 32716898 | We identified examples demonstrating safety and feasibility of virtual diabetes clinics, which aligns with our own clinical experience during the pandemic. | 2020-07-28 |
| 32716899 | This study aimed to estimate the prevalence of anxiety and depressive symptoms and identify associated demographic and psychosocial factors in the general Chinese population during the COVID-19 pandemic quarantine period. […] The survey included questions on demographics, family relationships, chronic diseases, quarantine conditions, lifestyle, COVID-19 infection, and anxiety and depressive symptoms. […] Logistic regression analyses were conducted to identify factors associated with elevated anxiety or depressive symptoms. […] Out of 2331 participants, 762 (32.7%) experienced elevated anxiety or depressive symptoms. […] Nine risk factors associated with anxiety or depressive symptoms included younger age, reduced income, having cancer or other chronic diseases, having family members living with cancer, concerns related to COVID-19 infection for themselves or family members, living alone, having family conflicts, having <3 or >8 hours of sedentary time per day, and worsened sleep quality. […] The findings highlight an urgent need for psychological support for populations at high risk for elevated anxiety or depressive symptoms during the COVID-19 pandemic. | 2020-07-28 |
| 32716901 | Information about the clinical characteristics of patients with COVID-19 who were not admitted to hospital is limited. […] The demographic, epidemiological, clinical, and radiological features of the patients were extracted from their social media posts and coded. […] Telephone follow-up was conducted 1 month later (between March 15 and 23, 2020) to check the clinical outcomes of the patients and acquire other relevant information. | 2020-07-28 |
| 32716922 | An improved ability to predict a patient’s clinical course would facilitate optimal care decisions, resource allocation, family counseling, and strategies for safely easing distancing restrictions. […] This multisite retrospective study of 6591 Veterans diagnosed with COVID-19 from March 2, 2020 to May 26, 2020 was designed to assess the utility of repurposing the CAN score as objective and automated risk assessment tool to promptly enhance clinical decision making for Veterans diagnosed with COVID-19. […] As a result of the compelling statistical results, and automation, this tool is well positioned for broad use across the VA to enhance clinical decision-making. | 2020-07-28 |
| 32717052 | Antibodies to SARS-CoV-2 were detected in 303/673 rural Ecuadorian adults (45%), 77% of whom had compatible clinical manifestations. | 2020-07-28 |
| 32717056 | We compared the DiaSorin Liaison SARS-CoV-2 S1/S2 IgG and Roche Diagnostics Elecsys Anti-SARS-CoV-2 assays using 228 samples spanning patients with positive PCR for SARS-CoV-2, patients with compatible symptoms but negative PCR, pre-COVID specimens, and potential cross-reactives. | 2020-07-28 |
| 32717116 | Thus, following these patterns of skin inflammation, our review may supply treatment recommendations and thoughtful considerations for disease management even beyond the most frequent diseases discussed here. | 2020-07-28 |
| 32717210 | Symptomatic health-care workers with mild to moderate symptoms were eligible to participate 14 days after onset of COVID-19 symptoms, as per the Public Health England (PHE) case definition. […] Health-care workers were recruited to the asymptomatic cohort if they had not developed PHE-defined COVID-19 symptoms since Dec 1, 2019. […] In phase 2 (n=6440), serosurveillance was done among 1299 (93·4%) of 1391 health-care workers reporting symptoms, and in a subset of asymptomatic health-care workers (405 [8·0%] of 5049). […] Although a good positive predictive value was observed with both lateral flow serological assays and ELISA, this agreement only occurred if the pre-test probability was modified by a strict clinical case definition. […] Identification of false-negative results among health-care workers across all assays suggest caution in interpretation of IgG results at this stage; for now, testing is perhaps best delivered in a clinical setting, supported by government advice about physical distancing. | 2020-07-28 |
| 32717345 | The significant number of COVID-19 patients shows extra-pulmonary symptoms in the GI tract. | 2020-07-28 |
| 32717568 | The initial results of a number of clinical trials involving various protocols of administration of chloroquine or hydroxychloroquine mostly point towards their beneficial effect. […] Interestingly, azithromycin, a macrolide antibiotic in combination with hydroxychloroquine, might yield clinical benefit as an adjunctive. […] The results of clinical trials point to the potential clinical efficacy of antivirals, especially remdesivir (GS-5734), lopinavir/ritonavir, and favipiravir. […] We discuss a number of other drugs that are currently in clinical trials, whose results are not yet available, and in various instances we enrich such efficacy analysis by invoking historic data on the treatment of SARS, MERS, influenza, or in vitro studies. | 2020-07-28 |
| 32717711 | It has been consistently shown that a high proportion of HCWs is at greater risk for developing Posttraumatic Stress Disorder (PTSD) and Posttraumatic Stress Symptoms (PTSS). | 2020-07-28 |
| 32717743 | Thus, we have identified a maladapted immune response profile associated with severe COVID-19 and poor clinical outcome, as well as early immune signatures that correlate with divergent disease trajectories. | 2020-07-28 |
| 32717807 | This study opens a new potential avenue for the identification of sub-populations at risk, which could provide Health Services with a tool to define more targeted clinical management strategies and priorities in vaccination campaigns. | 2020-07-29 |
| 32718008 | We aimed to evaluate the time length of negativization from the onset of symptoms in healthcare workers (HCWs) with COVID-19, and to evaluate significant variations in cycle threshold (CT) values and gene positivity (E, RdRP, and N genes) among positive individuals who returned to work. | 2020-07-29 |
| 32718020 | Nevertheless, researchers have swiftly responded to the pandemic by advancing old and new potential therapeutics into clinical trials. […] The review presents the structures, mechanisms, and reported results of clinical trials of potential therapeutics that have been listed in clinicaltrials.gov. | 2020-07-29 |
| 32718127 | The demographic, laboratory, and clinical data were collected. […] Patients admitted within a median of 3 days (0-14 days) after symptoms appear. | 2020-07-29 |
| 32718560 | An ongoing pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19 appears to present with 3 major patterns of clinical symptomatology: (1) mild upper respiratory tract infection, (2) non-life-threatening pneumonia, and (3) severe pneumonia and acute respiratory distress syndrome that initially manifest as a mild prodrome lasting for 7-8 days before rapid clinical and radiological deterioration requiring ICU transfer. […] This small molecule, which has been evaluated in multiple Phase 1-2 clinical trials for cancer as well as a Phase 3 clinical trial for the treatment of small cell lung cancer called REPLATINUM (NCT03699956), is minimally toxic and demonstrates clear evidence of antitumor activity. […] During the course of these clinical trials it was noted that the rate of chronic obstructive pulmonary disease exacerbation and pneumonia in actively smoking small cell lung cancer patients treated with RRx-001 is less than 1%. […] Due to extensive history of tobacco use, 40%-70% of patients with lung cancer have chronic obstructive pulmonary disease and the expected rate of pulmonary infection in this population is 50%-70%, which was not observed in RRx-001 clinical trials. […] Moreover, in preclinical studies of pulmonary hypertension, RRx-001 was found to be comparable with or more effective than the FDA approved agent, Bosentan. […] The potential pulmonary protective effects of RRx-001 in patients with recurrent lung infections coupled with preclinical models demonstrating RRx-001-mediated reversal of pulmonary hypertension suggests RRx-001 may have therapeutic activity in patients with acute respiratory symptoms due to COVID 19. […] Clinical trials have been initiated to confirm the hypothesis that RRx-001 may be repurposed to treat SARS-CoV-2 infection. | 2020-07-29 |
| 32718670 | Finally, the purpose of this review is to share this idea with health professionals to ignite the debate and call for critical reflection, so that it can contribute to the undertaking of more and better clinical designs to validate the benefits of using high doses of vitaminD for the benefit of public health and especially in times of crisis for COVID-19. | 2020-07-29 |
| 32718715 | Drugs that are being essayed to counteract both clinical phases that are thought to take place in the severe stage of this disease are included; an initial phase where a viral infection prevails and a second phase where an inflammatory response takes over. | 2020-07-29 |
| 32718772 | The highly transmissible novel coronavirus (COVID-19) has infected over 8.8 million people globally and has upended the delivery of health care in the United States, creating unprecedented challenges to providing care to patients with early stage non-small cell lung cancer (NSCLC). […] This article will address the current challenges with treating early stage NSCLC during the COVID-19 pandemic and provide a clinical framework for providing effective surgical therapy while mitigating the risk of transmission of the SARS-CoV-2 virus to patients and surgeons. | 2020-07-29 |
| 32718855 | We aim to assess COVID-19 outbreak-related emotional symptoms, identify gender differences, and study the relationship between the emotional state and environmental features in the elderly. […] Symptoms of anxiety (Hamilton Anxiety Scale), depression (Beck Depression Inventory) and acute stress (Acute Stress Disorder Inventory) were compared between people over and under 60 years old. […] There were no gender differences in any of the clinical measures. | 2020-07-29 |
| 32718892 | Demographic, clinical, epidemiological and laboratory data were extracted from outbreak investigation reports and medical records. | 2020-07-29 |
| 32718894 | We aimed to describe the epidemiology and clinical characteristics of hospitalized COVID-19 patients, and to investigate the potential risk factors for COVID-19 severity. 1663 hospitalized patients with laboratory-confirmed diagnosed COVID-19 from Tongji Hospital between January 14, 2020, and February 28, 2020 were included in the present study. […] Demographic information, exposure history, medical history, comorbidities, signs and symptoms, chest computed tomography (CT) scanning, severity of COVID-19 and laboratory findings on admission were collected from electronic medical records. […] Fever (85.8%), cough (36.0%), fatigue (23.6%) and chest tightness (11.9%) were the most common symptoms in COVID-19 patients. | 2020-07-29 |
| 32718896 | Earlier sampling after symptom onset was associated with improved detection rates, but the differences in SARS-CoV-2 RNA detection by sampling method was consistent regardless of the duration of symptoms. | 2020-07-29 |
| 32718919 | The European Society for Medical Oncology (ESMO) has endorsed a tiered approach across three different levels of priority (high, medium, low) incorporating information on the value-based prioritisation and clinical cogency of the interventions that can be applied for different disease sites. […] The definition of priority level should be based on tumour stage and histology, cancer-related symptoms or complications, aim (curative vs palliative) and magnitude of benefit of the oncological intervention, patients’ general condition and preferences. […] These recommendations aim to provide guidance for the definition of deferrable and undeferrable interventions during the COVID-19 pandemic for ovarian, endometrial and cervical cancers within the context of the ESMO Clinical Practice Guidelines. | 2020-07-29 |
| 32719039 | To evaluate the clinical pictures, laboratory tests and imaging of patients with lung involvement, either from severe COVID-19 or macrophage activation syndrome (MAS), in order to assess how similar these two diseases are. | 2020-07-29 |
| 32719045 | To prospectively investigate in patients with severe COVID-19-associated cytokine storm syndrome (CSS) whether an intensive course of glucocorticoids with or without tocilizumab accelerates clinical improvement, reduces mortality and prevents invasive mechanical ventilation, in comparison with a historic control group of patients who received supportive care only. […] At baseline all patients with COVID-19 in the treatment group (n=86) and control group (n=86) had symptoms of CSS and faced acute respiratory failure. | 2020-07-29 |
| 32719204 | We used repeatedly tested positive clinical sample elutes having different levels of SARS CoV 2 RNA and negative sample elutes to prepare seven series of 11 pools each, having pool sizes ranging from 2 to 48 samples to estimate the optimal pool size. | 2020-07-29 |
| 32719214 | This study aims to provide scientific basis for rapid screening and early diagnosis of the coronavirus disease 2019 (COVID-19) through analysing the clinical characteristics and early imaging/laboratory findings of the inpatients. […] The clinical characteristics and imaging/laboratory findings including chest computed tomography (CT), initial blood count, C-reactive protein [CRP]), procalcitonin (PCT) and serum total IgE were captured and analysed. […] (1) The first symptoms of all age groups were primarily fever (76%), followed by cough (12%) and dyspnoea (5%). […] (2) Fever was the most common clinical manifestation (80%), with moderate fever being the most common (40%), followed by low fever in patients above 40 years old and high fever in those under 40 years (35%). […] Cough was the second most common clinical manifestation and was most common (80%) in the middle-aged. […] Chest pain was more common in the youth (13%), and 13% of the youth had no symptoms. […] The clinical characteristics and imaging/laboratory findings of COVID-19 patients vary in different age groups. | 2020-07-29 |
| 32719218 | The cumulative incidence of the requirement for mechanical ventilation, clinical improvement and mortality was 11% (95% CI: 0.03%-1%), 74% (95% CI 37%-89%) and 25% (95% CI: 11%-63%), respectively. […] TCZ is likely a safe and effective modality of treatment for improving clinical and laboratory parameters of SARS CoV-2 patients with a reduction in ICU stay and ventilatory care need. | 2020-07-29 |
| 32719447 | We provide a broad review of the clinical evolution of COVID-19, emphasizing its impact and implications on the cardiovascular system. | 2020-07-29 |
| 32719646 | The lack of support these children receive in such a difficult moment may be the reason for their more pronounced psychological symptoms. | 2020-07-29 |
| 32719655 | PwE had worse depressive and anxiety symptoms (higher BDI-II and GAD-7 scores; p < 0.001) than PwoE. | 2020-07-29 |
| 32719683 | In the present manuscript, we provide an analysis of the rationale underlying the application of stem cells to manage COVID-19, and also a comprehensive compendium of the 69 clinical trials underway worldwide aiming to investigate the application of stem cells to treat COVID-19. | 2020-07-29 |
| 32719684 | Our literature and clinical trial survey showed that the whole virus, as well as the spike (S) protein, nucleocapsid (N) protein, and membrane (M) protein, have been tested for vaccine development against SARS and MERS. […] Our Vaxign analysis found that the SARS-CoV-2 N protein sequence is conserved with SARS-CoV and MERS-CoV but not from the other four human coronaviruses causing mild symptoms. | 2020-07-29 |
| 32719685 | COVID-19 is a clinical syndrome ranging from mild symptoms to severe pneumonia that often leads to respiratory failure, need for mechanical ventilation, and death. […] Blunting this hyperinflammation with immunomodulation may lead to clinical improvement. […] Anti-GM-CSF monoclonal antibodies, TJ003234 and gimsilumab, will be tested in clinical trials in patients with COVID-19, while lenzilumab received FDA approval for compassionate use. | 2020-07-29 |
| 32719688 | We report a case of an 8-year-old girl who underwent a SARS-CoV-2 infection manifesting with atypical symptoms spearheaded by abdominal discomfort and systemic inflammation and partially mimicking hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS), which however did not fulfill the HLH/MAS diagnostic criteria. […] In this case of what has since been described as Pediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-COV-2 (PIMS-TS) we documented excellent clinical response to immunosuppression with systemic corticosteroids and intravenous immunoglobulins. | 2020-07-29 |
| 32719737 | The clinical symptoms are mainly upper respiratory leading to diffuse viral pneumonia and multiple organ failure involving. | 2020-07-29 |
| 32719750 | This study describes the clinical characteristics, including multiple recurrences of COVID-19, in a patient with chronic lymphocytic leukemia (CLL) during 69 days of follow-up. | 2020-07-29 |
| 32719759 | Methods: A random-effect meta-analysis was conducted to determine the characteristics of children with COVID-19, including their demographic, epidemiological, clinical, laboratory, imaging features, and outcomes. […] Fever (51.2%, 95% CI = 40.2-62.2) and cough (37.0%, 95% CI = 25.9-48.8) were the most frequent symptoms. | 2020-07-29 |
| 32719766 | Methods: In this retrospective cohort study, we analyzed data from 28 corticosteroid-treated patients with non-severe but advanced COVID-19, in which short-course and low-dose corticosteroids were administered because of unremitting or worsening clinical conditions during hospitalization. […] Conclusion: Short-course and low-dose applications of corticosteroids, when co-administered with intravenous immunoglobulin, in non-severe COVID-19 patients during the stage of clinical deterioration may possibly prevent disease progression, while having a negligible impact on the viral clearance. | 2020-07-29 |
| 32719804 | Aim: Clinical findings indicated that a fraction of coronavirus disease 2019 (COVID-19) patients did not show fever. […] However, the difference between the clinical characteristics of fevered and non-fevered patients is still unclear. […] The aim of the present study was to describe the clinical characteristics of these patients and analyze the predictors for severe events of adult fevered COVID-19 patients. […] Methods: Clinical and laboratory data of fevered and non-fevered COVID-19 patients in Changsha, China, were collected and analyzed. | 2020-07-29 |
| 32719806 | Demographic, clinical characteristics, comorbidities, and chest computed tomography (CT) image, mental state, medication status, and nucleic acid test data were summarized and analyzed. […] Cough/expectoration are the most common symptoms, followed by chest congestion/dyspnea during the 2 weeks post-discharge quarantine. […] Risk factors of nucleic acid re-positivity including the number of lobes infiltration (odds ratio[OR], 1.14; 95% CI, 1.09-1.19), distribution (OR, 0.16; 95% CI, 0.13-0.19), CT imaging feature of patchy shadowing accompanying with consolidation (OR, 9.36; 95% CI, 7.84-11.17), respiratory symptoms of cough accompanying with expectoration (OR, 1.39; 95% CI, 1.28-1.52), and chest congestion accompanying by dyspnea (OR, 1.42; 95% CI, 1.28-1.57). […] A few recovered patients may prolong the quarantine based on clinical symptoms and signs and nucleic acid results in the 2 weeks of medical observation. | 2020-07-29 |
| 32719808 | We report the clinical features of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a family setting of 13 people with person-to-person transmission in Yancheng, Jiangsu Province, China. | 2020-07-29 |
| 32719810 | This disease is initiated by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and uncontrolled cytokine storm, but it remains unknown as to whether a robust antibody response is related to clinical deterioration and poor outcome in COVID-19 patients. […] Conclusions: COVID-19 severity is associated with increased IgG response, and an immune response phenotyping based on the late IgG response and NLR could act as a simple complementary tool to discriminate between severe and non-severe COVID-19 patients, and further predict their clinical outcome. | 2020-07-29 |
| 32719848 | All included participants underwent screening protocol for invasive pulmonary aspergillosis with bronchoalveolar lavage galactomannan and cultures performed on admission at 7 days and in case of clinical deterioration. | 2020-07-29 |
| 32719874 | Improved understanding of SARS-CoV-2 spectrum of disease is essential for clinical and public health interventions. […] We characterized symptom profiles on the date of first positive RT-PCR test and described progression of symptoms over time. […] The most commonly reported symptoms on the day of first positive RT-PCR test were upper respiratory (n=32, 68%) and neurologic (n=30, 64%); fever was not commonly reported (n=9, 19%). […] Eight (17%) individuals were asymptomatic at the date of first positive RT-PCR collection; two (4%) had preceding symptoms that resolved and six (13%) subsequently developed symptoms. […] Children less frequently reported lower respiratory symptoms (age <18: 21%, age 18-49: 60%, age 50+ years: 69%; p=0.03). […] Household contacts with lab-confirmed SARS-CoV-2 infection reported mild symptoms. […] When assessed at a single time-point, several contacts appeared to have asymptomatic infection; however, over time all developed symptoms. | 2020-07-29 |
| 32719902 | Coronavirus disease 2019 (COVID-19) infection has the potential for targeting the central nervous system, and several neurological symptoms have been reported in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] The clinical picture, perceived as foreign accent syndrome (FAS), was not associated with structural and functional imaging changes or neurophysiological assessment abnormalities. | 2020-07-29 |
| 32719932 | SARS CoV-2 (COVID-19) represents a pandemic that has led to adjustments of routine clinical practices. | 2020-07-29 |
| 32720013 | The clinical manifestations of coronavirus disease 2019 (COVID-19) are non-specific and multi-inflammatory. | 2020-07-29 |
| 32720082 | Guideline-directed medical therapy for heart failure should not be interrupted for theoretical concerns but rather based on tolerance and clinical presentation. | 2020-07-29 |
| 32720109 | Though necessary, cancellations result in an increasing backlog of cases that poses significant future logistical and clinical challenges in an already overburdened safety-net hospital. | 2020-07-29 |
| 32720223 | Gastrointestinal symptoms are also frequently encountered and may persist for several days. […] Furthermore, recent studies have reported that over a third of infected patients develop a broad spectrum of neurological symptoms affecting the central nervous system, peripheral nervous system and skeletal muscles, including anosmia and ageusia. | 2020-07-29 |
| 32720239 | Most patients infected with SARS-CoV-2 have mild to moderate symptoms manageable at home; however, up to 20% develop severe illness requiring additional support. | 2020-07-29 |
| 32720256 | Our search did not reveal any relevant randomized clinical trials or cohort studies. | 2020-07-29 |
| 32720259 | Studying epidemiological and clinical characteristics of patients with rheumatic diseases infected with SARS-CoV2 is pivotal to clarify determinants of COVID-19 disease severity in patients with underlying rheumatic disease. […] No differences in sex, radiological abnormalities, rheumatological disease, background therapy or symptoms before admission between deceased patients and survivors were found. | 2020-07-29 |
| 32720316 | Using a preclinical model, an objective assessment of drill induced droplet spread was undertaken during simulated cochlear implant (CI) surgery and mitigated via the use of a protective drape ‘tent’. […] The ensemble of a half-face mask and safety spoggles (foam lined safety goggles) had consistently superior performance across all aspects of clinical usability. […] The results of this preclinical study indicate that the most viable solution to enable the safe conduct of CI and other mastoid surgery is a combination of an FFP3 mask or half-face respirator with safety spoggles as PPE. […] A multi-centre clinical trial to evaluate the effectiveness of PPE should be the next step towards safely performing CI surgery during the COVID-19 era. | 2020-07-29 |
| 32720374 | The two most important parameters used to triage were symptoms and valve area. | 2020-07-29 |
| 32720399 | Participants in the United States (US, N = 511) and the Netherlands (NL, N = 510), recruited through ongoing studies and social media, completed an online survey that included both quantitative measures and free-text responses assessing the impact of COVID-19 on situational circumstances, eating disorder symptoms, eating disorder treatment, and general well-being. | 2020-07-29 |
| 32720612 | The study primary endpoint was the aggregate dynamics of patients’ condition as evaluated by an original CCS-COVID scale, which included, in addition to the clinical status, assessments of changes in the inflammation marker, C-reactive protein (CRP); the thrombus formation marker, D-dimer; and the extent of lung injury evaluated by computed tomography (CT). […] Shortness of breath considerably decreased; oxygen saturation increased, and the NEWS-2 clinical status scale scores decreased. | 2020-07-29 |
| 32720641 | An analysis of airflow records from the CPAP machine revealed a rise in his respiratory rate on the night before the onset of COVID-19-related symptoms, while his nocturnal respiratory rate had been stable during the 18-month period prior to the presently reported episode. | 2020-07-29 |
| 32720649 | BACKGROUND The aim of this study was to describe the clinical characteristics and outcomes of patients with coronavirus disease 2019 (COVID-19) and compare these parameters in an elderly group with those in a younger group. […] Epidemiological, demographic, clinical, and laboratory data, as well as treatments, complications, and outcomes were extracted from electronic medical records and compared between elderly patients (aged ≥60 years) and younger patients (aged <60 years). | 2020-07-29 |
| 32720688 | The contact person should collaborate with professionals in order to prepare a prevention and intervention plan that considers national provisions and scientific evidence, the requirements for reporting patients with symptoms compatible with COVID-19, the indications for the management of suspected, probable or confirmed cases of COVID-19. | 2020-07-29 |
| 32720698 | To evaluate the clinical characteristics and rehabilitation management of patients who undergo amputation for COVID-19-associated coagulopathy. […] Clinical and laboratory data for 3 patients were analysed and their rehabilitative management discussed. […] The medical records of 3 patients who had undergone amputation due to acute lower extremity ischaemia and who were provided with rehabilitation in our COVID-19 unit were reviewed. […] The rehabilitation management of amputated patients for COVID-19 acute lower extremity ischaemia is based on a multilevel approach for clinical, functional, nutritional and neuropsychological needs. | 2020-07-29 |
| 32720702 | Patients were divided into those admitted to the intensive care unit (ICU group) and those not (no ICU group), and clinical data including usage of tocilizumab were compared. […] Correlation between IL-6 value at admission and at peak, and tocilizumab use, as well as clinical outcomes were also investigated. | 2020-07-29 |
| 32720703 | This disease is associated with a wide range of symptoms, which makes accurate diagnosis of it difficult. […] This finding made us think that the wide range of symptoms and also relatively high prevalence of death in our patients may be due to the coinfection with other viruses. | 2020-07-29 |
| 32720706 | Clinical data were also analyzed. | 2020-07-29 |
| 32720761 | Establishing updated treatments and care management regulations for lung cancer patients during the COVID-19 pandemic, based on worldwide clinical experience. | 2020-07-29 |
| 32720844 | The addition of the telemedicine model has allowed many physicians to resume their clinical duties while maintaining social distancing. | 2020-07-29 |
| 32720978 | Furthermore, gastrointestinal (GI) symptoms are common in COVID-19 patients including watery diarrhea, vomiting-particularly in children-nausea, and abdominal pain. | 2020-07-29 |
| 32721038 | Patients with 2019 novel coronavirus disease (COVID-19) could present with gastrointestinal symptoms without fever or respiratory manifestations, which could be overlooked by health-care providers. […] We aimed to evaluate the clinical characteristics of COVID-19 in patients presenting with initial gastrointestinal symptoms. […] We divided these patients into two groups: patients with initial gastrointestinal symptoms (group A, n = 183) and patients with respiratory syndrome and/or fever (group B, n = 1228). […] The clinical characteristics, radiological features, and laboratory data were assessed. […] The clinical procedures of both groups underwent 1-2 weeks rising period and were downward trend at 3 weeks; less than 5% of patients progressed to critical illness. […] COVID-19 patients presented with initial gastrointestinal symptoms had similar clinical characteristics and outcomes, when compared with patients with fever and respiratory symptoms. | 2020-07-29 |
| 32721199 | None of the neonates developed clinical symptoms of COVID-19. | 2020-07-30 |
| 32721252 | The current pandemic of COVID-19 and the identification of accessible biomarkers of disease progression is of clinical importance in the management of this novel and serious disease. […] A literature search was undertaken to provide medical data regarding EDN-1 as a biomarker in the clinical setting. […] The literature identified was further analyzed to identify its use in the clinical setting of viral disease and asthma. | 2020-07-30 |
| 32721387 | Predictive models of COVID-19 diagnosis were performed based on radiology, clinical and laboratory findings; bootstrapping was performed in order to account for overfitting. […] We propose a predictive score that can be easily applied in clinical practice. | 2020-07-30 |
| 32721449 | Some of the clinical studies showed very good effect of chloroquine and hydroxychloroquine against COVID-19, however, they were not recommended due to serious clinical toxicity. | 2020-07-30 |
| 32721528 | This can guide clinical management pending results from randomized controlled trials. | 2020-07-30 |
| 32721533 | Chronic comorbidities, including obesity, hypertension, diabetes, cardiovascular disease, cerebrovascular disease, respiratory disease, kidney disease, and malignancy are clinical risk factors for a severe or fatal outcome associated with COVID-19, with obesity being the most prevalent and respiratory disease being the most strongly predictive. | 2020-07-30 |
| 32721580 | Recently, the Food and Drug Agency (FDA) and the European Medicines Agency (EMA) recommended remdesivir for the treatment of patients hospitalized with severe coronavirus disease 2019 (COVID-19) infection.1,2 In the remdesivir clinical development program, some cases have raised concerns regarding potential hepatobiliary disorders associated with remdesivir, including in healthy volunteers and patients with COVID-19.3 In cohort studies of patients hospitalized for severe COVID-19 who were treated with compassionate-use remdesivir, elevated hepatic enzymes were the most frequent adverse drug reaction reported.4,5 In the first randomized, double-blind, placebo-controlled clinical trial assessing the effect of intravenous remdesivir in adults admitted to hospital with severe COVID-19 (n = 237), a higher proportion of remdesivir recipients than placebo recipients had dosing prematurely stopped by the investigators because of adverse events including aminotransferase or bilirubin increases (3 versus 0).6 Although there is no signal from the available data of severe hepatotoxicity or drug-induced liver injury in clinical trials, the number of patients exposed to remdesivir was too limited. | 2020-07-30 |
| 32721795 | These preliminary clinical findings indicate that the relatively rapid recovery of olfactory and gustative function can mean a resolution of viral infection in most patients. […] Olfactory and gustatory functional impairment has been recognized as a hallmark of COVID-19 and may be an important predictor of clinical outcome. […] Our study supports the need to add anosmia and dysgeusia to the list of symptoms used in screening tools for possible COVID-19 infection. | 2020-07-30 |
| 32721799 | Thousands of studies are being devoted to understanding its epidemiology, its molecular characteristics, its mechanisms, and the clinical evolution of this viral infection. | 2020-07-30 |
| 32721808 | If the proposal put forth in this paper can be confirmed either wholly or in part, it would have significant implications in terms of strategies aimed at minimizing the severity of COVID-19 in a clinical setting. | 2020-07-30 |
| 32721922 | To our knowledge, there are few publications describing how digital tools have been used to ameliorate psychological symptoms among individuals. […] The aim of this review was to identify existing SMS text message, web-based, mobile, and conversational agents that the general public can access to ameliorate the psychological symptoms they are experiencing during the COVID-19 pandemic. […] Digital tools that are commercially available may be useful for at-risk individuals or individuals with pre-existing psychiatric symptoms. | 2020-07-30 |
| 32721925 | During the recent coronavirus disease (COVID-19) pandemic, telehealth has received greater attention due to its role in reducing hospital visits from patients with COVID-19 or other conditions, while supporting home isolation in patients with mild symptoms. | 2020-07-30 |
| 32722020 | There is limited information available describing the clinical and epidemiological features of Spanish patients requiring hospitalization for coronavirus disease 2019 (COVID-19). […] In this observational study, we aimed to describe the clinical characteristics and epidemiological features of severe (non-ICU) and critically patients (ICU) with COVID-19 at triage, prior to hospitalization. […] Initial symptoms included fever (100%), coughing (85%), dyspnea (76%), diarrhea (42%) and asthenia (21%). | 2020-07-30 |
| 32722042 | This paper focuses on the utilization of a clinical practice protocol for identifying HCWs who are COVID-19-positive or under investigation and surveillance for suspected infection, in a tertiary, university teaching hospital of Malaysia. | 2020-07-30 |
| 32722202 | As perceived job insecurity is associated with psychological distress and Italian dentists have been highly affected by the COVID-19 outbreak in terms of potential financial loss and the risk of being infected, this study aimed at assessing whether the fear of COVID-19 moderated the effect of perceived job insecurity on depressive symptoms. […] The results indicated that both perceived job insecurity and fear of COVID-19 were positively associated with depressive symptoms, and that the effect of perceived job insecurity on depressive symptoms was weaker among those with a low fear of COVID-19. | 2020-07-30 |
| 32722217 | There exist unresolved gaps in care as a result of the healthcare structure and underutilized skills of trained pharmacists who do not have the federal means to provide clinical services. | 2020-07-30 |
| 32722343 | The aim of this study is the characterization and genomic tracing by phylogenetic analyses of 59 new SARS-CoV-2 Italian isolates obtained from patients attending clinical centres in North and Central Italy until the end of April 2020. | 2020-07-30 |
| 32722574 | The clinical treatment of the severe acute respiratory syndrome (SARS) CoV-2 is currently based on the experimental administration of HIV antiviral drugs, such as lopinavir, ritonavir, and remdesivir (a nucleotide analogue used for Ebola infection). […] Increased catabolism of NAD(H) during protein ribosylation in the DNA damage repair process may explain the greater susceptibility of the elderly population to the acute respiratory symptoms of COVID-19. | 2020-07-30 |
| 32722715 | Reliable estimates of mortality from SARS-CoV-2 infection are essential for understanding clinical prognosis, planning healthcare capacity, and epidemic forecasting. […] The sCFR and IFR, adjusted for right-censoring and preferential ascertainment of severe cases, are measures that can be used to improve and monitor clinical and public health strategies to reduce the deaths from SARS-CoV-2 infection. | 2020-07-30 |
| 32722722 | Previous studies revealed pregnant women with COVID-19 had similar clinical manifestations to nonpregnant women. […] Maternal demographic characteristics, delivery course, symptoms, and laboratory tests from hospital records were extracted. […] Neonates were hospitalized if they had symptoms (5 cases) or their guardians agreed to a hospitalized quarantine (13 cases), whereas symptom-free neonates also could be discharged after birth and followed up through telephone (12 cases). […] Among 29 pregnant COVID-19-infected women (13 confirmed and 16 clinical diagnosed), the majority had higher education (56.6%), half were employed (51.7%), and their mean age was 29 years. […] Fourteen women experienced mild symptoms including fever (8), cough (9), shortness of breath (3), diarrhea (2), vomiting (1), and 15 were symptom-free. […] Of 30 neonates, 18 were admitted to Wuhan Children’s Hospital for quarantine and care, whereas the other 12 neonates discharged after birth without any symptoms and had normal follow-up. […] In addition, 12 of 13 other hospitalized neonates presented with radiological features for pneumonia through X-ray or CT screening, 1 with occasional cough and the others without associated symptoms. […] These findings suggest that intrauterine or intrapartum transmission is possible and warrants clinical caution and further investigation. […] Chinese Clinical Trial Registry, ChiCTR2000031954 (Maternal and Perinatal Outcomes of Women with coronavirus disease 2019 (COVID-19): a multicenter retrospective cohort study). | 2020-07-30 |
| 32722749 | The COVID-19 pandemic response in the United States has exposed significant gaps in information systems and processes to enable timely clinical and public health decision-making. […] Specifically, the use of informatics to mitigate the spread of SARS-CoV-2, support COVID-19 care delivery, and accelerate knowledge discovery bring to the forefront issues of privacy, surveillance, limits of state powers, and interoperability between public health and clinical information systems. […] Using a consensus building process, we critically analyze informatics-related ethical issues in light of the pandemic across three themes: (1) public health reporting and data sharing, (2) contact tracing and tracking, and (3) clinical scoring tools for critical care. | 2020-07-30 |
| 32722754 | However, all IBD patients with symptoms should be tested for SARS-CoV-2 and the procedures for disease management should be carefully adapted: [i] in SARS-CoV-2-positive IBD patients, medical treatments should be re-evaluated [with a particular focus on corticosteroids] always with the purpose of treating active disease and maintaining remission; [ii] non-urgent surgeries and endoscopic procedures should be postponed for all patients; [iii] online consultancy should be implemented; and [iv] hospitalization and surgery should be limited to life-threatening situations. | 2020-07-30 |
| 32722864 | We present a docking-based screening using a quantum mechanical scoring of a library built from approved drugs and compounds undergoing clinical trials, against three SARS-CoV-2 target proteins: the spike or S-protein, and two proteases, the main protease and the papain-like protease. […] Following the analysis of our structure-based compound screening, we propose several structurally diverse compounds (either FDA-approved or in clinical trials) that could display antiviral activity against SARS-CoV-2. […] Clearly, these compounds should be further evaluated in experimental assays and clinical trials to confirm their actual activity against the disease. | 2020-07-30 |
| 32722927 | The clinical features of COVID-19 include dry cough, fever, diarrhea, vomiting, and myalgia. | 2020-07-30 |
| 32722946 | Main clinical manifestations of SARS-CoV-2 infection are characterized by fever, dyspnea, and interstitial pneumonia, frequently evolving in acute respiratory distress syndrome (ARDS). | 2020-07-30 |
| 32722961 | These concerns are related to the impact of excessive alcohol consumption in a person with COVID-19 and/or with alcohol use disorder, as well as with a potential increase in the prevalence of harmful drinking, alcohol use disorder, withdrawal symptoms, intimate partner violence, harm to children, suicide, mental health problems and non-communicable diseases. | 2020-07-30 |
| 32722963 | To provide a rapid clinical update on the evidence for telehealth in mental healthcare in the context of the COVID-19 pandemic public health measures. | 2020-07-30 |
| 32722980 | Therefore, we carried out a study on the clinical characteristics of HD patients with COVID-19. […] The clinical features of patients include epidemiology, clinical symptoms, laboratory and imaging test, treatment and prognosis. […] Clinical symptoms include cough (85%), fever (43%), and shortness of breath (48.4%), etc. […] Moreover, HD patients have more severe infection and inflammation with less symptoms and worse outcome. | 2020-07-30 |
| 32722990 | Some asymptomatic carriers developed mild or moderate symptoms during hospitalization. | 2020-07-30 |
| 32723027 | To recognise clinical features of COVID-19 pneumonia and its differences from influenza pneumonia. 246 patients were enrolled into COVID-19 cohort and 120 patients into influenza cohort. […] The variables under focus included demographic, epidemiological, clinical, laboratory and imaging characteristics of COVID-19 pneumonia and comparison were made with influenza pneumonia. | 2020-07-30 |
| 32723081 | A four-pronged strategy including (1) personnel segregation, (2) triaging and decantment, (3) use of personal protective equipment and (4) changes in clinical practice was employed. | 2020-07-30 |
| 32723104 | Given the current SARS-CoV-2 (COVID-19) pandemic, the availability of reliable information for clinicians and patients is of extreme importance Although accumulating evidence support the existence of a harmful effect of NSAIDs in some infectious settings, no clinical studies demonstrating that such risk applies in case of COVID-19. […] Pending further research, a pragmatic and cautionary approach would be to avoid regular NSAID use or as first line option in suspicion of COVID19 symptoms. | 2020-07-30 |
| 32723107 | Between March 15th and April 14th, 2020, 279 COVID-19 patients were hospitalized after a median of 7 days after the first symptoms. […] We identified seven easily available prognostic factors and proposed a simple nomogram for early detection of patients at risk of aggravation, in order to optimize clinical care and initiate specific therapies. […] We propose an easy-to-use nomogram to predict unfavourable outcome for hospitalized adult patients to optimize clinical care and initiate specific therapies. | 2020-07-30 |
| 32723108 | Medical records of 24 MMP patients who were treated with 500 mg RTX on day 1, then weekly for 4 consecutive weeks were reviewed. | 2020-07-30 |
| 32723142 | Repositioned drugs such as remdesivir have revealed a promising clinical efficacy against COVID-19. | 2020-07-30 |
| 32723158 | Objective: In light of the COVID-19 pandemic, a majority of clinicians have had to quickly and dramatically alter their clinical practices. […] Two surveys were administered on 3/26/2020 and 3/30/2020, respectively, to document immediate changes and challenges in clinical practice.Method: Two surveys were administered between 3/26/2020 and 3/30/2020, via SurveyMonkey and Google Forms, asking clinicians questions pertaining to practice issues during the early stages of the COVID-19 pandemic. […] Quantitative responses from the second survey were stratified by clinical setting (Medical Hospital vs. […] Respondents requested clear best-practice guidelines from neuropsychological practice organizations.Conclusions: It is clear that field of neuropsychology has drastically shifted clinical practices in response to COVID-19 and is likely to continue to evolve. […] While these responses were collected in the early stages of stay-at-home orders, policy changes continue to occur and it is paramount that practice organizations consider the initial challenges expressed by clinicians when formulating practice recommendations and evaluating the clinical utility of telehealth services. | 2020-07-30 |
| 32723229 | The pathogenic impact of HMGB1 to the severe acute respiratory syndrome (SARS) and disease management with herbal formulations targeting this unique protein have already been proposed. […] In this paper, we focused on the potential usage of external and/or inhalation preparation of antiviral/antibacterial herbal products capable of targeting HMGB1 for the clinical management candidates of the ongoing COVID-19 infection. | 2020-07-30 |
| 32723327 | This particular clinical presentation in COVID-19 patients contrasts with the experience of physicians usually treating critically ill patients in respiratory failure and ensuring timely referral to the intensive care unit can, therefore, be challenging. […] A thorough understanding of the pathophysiological determinants of respiratory drive and hypoxemia may promote a more complete comprehension of a patient’s clinical presentation and management. | 2020-07-30 |
| 32723359 | Our data emphasises that the viral genome sequence should be carefully monitored during the growth of viral stocks for research, animal challenge models and, potentially, in clinical samples. | 2020-07-30 |
| 32723427 | Mice were followed twice daily for 5 days and scored for weight loss and clinical symptoms. […] Infected mice did not exhibit any signs of infection until day 4, when no other obvious clinical symptoms other than weight loss were observed. […] By day 5, all infected mice had lost around 10% of their original body weight but exhibited variable clinical symptoms. | 2020-07-30 |
| 32723434 | We aimed to investigate antiphospholipid antibodies (aPL) prevalence and clinical relationships in a large cohort of COVID-19 patients. | 2020-07-30 |
| 32723435 | Clinical presentation of COVID-19 was typical, with systemic symptoms (fever and asthenia) and respiratory symptoms. | 2020-07-30 |
| 32723442 | This systematic review discusses epidemiology, pathogenesis, transmission, clinical manifestations, severity, treatment, prevention, vaccination, medication repositioning, potential drug candidates, and control and public awareness of COVID-19. | 2020-07-30 |
| 32723443 | This article aimed to investigate the history, virology, epidemiology, clinical manifestations, pathophysiology and management of COVID-19 disease, in general, and the pathogenetic mechanisms of severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV2)-induced kidney damage, in particular. […] Keywords like SARS-CoV2, COVID-19, renal impairment, sepsis, viremia, etc. were used to find relevant publications from PubMed, Scopus, Google Scholar, and clinical trials registry websites. | 2020-07-30 |
| 32723446 | He was managed in intensive care unit (ICU) with broad-spectrum antibiotics, hydroxychloroquine alongwith anticoagulants; but he remained hypoxic with rapidly worsening clinical course, requiring mechanical ventilation; and ultimately succumbed to the disease. | 2020-07-30 |
| 32723447 | Its symptoms most commonly include, dry cough, fever, myalgia, and fatigue. | 2020-07-30 |
| 32723450 | We present five cases that presented to the hospital with mild symptoms, where the CT scan findings were disproportionate to the symptoms thus leading to effective triage. | 2020-07-30 |
| 32723453 | With the current spectrum of clinical presentations of patients with COVID-19, it is important to be thorough while determining symptoms involving the various organ systems including possible contact history. […] The author suggests a tool that incorporates various aspects in clinical history, POC lung ultrasound findings and hemodynamic parameters for identification and management of patients during the COVID-19 pandemic. | 2020-07-30 |
| 32723623 | A total of 560 articles were initially found, after applying the selection criteria, 13 studies were included in the analysis, of which 8 were systematic reviews, 3 qualitative studies, 1 cross-sectional prospective pilot study and 1 clinical guide, which allowed identifying strategies for the approach grief and death attending to this moment of exceptionality covid19, influencing the competence management of health professionals in emotional support and accompaniment as well as the monitoring throughout the process, as well as in the communication with the family. | 2020-07-30 |
| 32723824 | We performed whole-genome sequencing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly from PCR+ clinical specimens and conducted a phylogenetic analysis of the outbreak. | 2020-07-30 |
| 32723996 | We describe here the clinical characteristics and computed tomography (CT) patterns in asymptomatic young patients who had laboratory-confirmed COVID-19. […] Demographics, clinical data and CT images of these patients were reviewed by 2 senior radiologists. […] They remained clinically stable with no deterioration of their respiratory symptoms suggesting stability in lung involvement. | 2020-07-30 |
| 32724028 | CASE REPORT A 55-year old man presented to the emergency department with nausea, generalized abdominal pain and diarrhea; he denied having a fever or any respiratory symptoms. […] CONCLUSIONS Despite the absence of respiratory symptoms, patients infected with SARS-CoV-2 may show atypical presentations, such as gastrointestinal symptoms. | 2020-07-30 |
| 32724238 | As the European and international provisions are hierarchically above the national provisions, the latter should be interpreted so that the non-compliance to the obligation to stay at home: a) does not constitute offence for a person tested positive to the virus, if therapeutic treatments resulting in hospitalization are deemed necessary; b) it does not constitute administrative offence if the subject proves, based on clinical and factual documented evidence, that leaving the house is necessary to avoid recrudescence of mental disorder. | 2020-07-30 |
| 32724296 | The persistent excessive inflammatory response can build up a clinical picture that is very difficult to manage and potentially fatal. | 2020-07-30 |
| 32724668 | The authors reviewed the clinical work arrangements during the epidemic situation at the Eye Hospital of Wenzhou Medical University in China and analyzed the prevention and control measures that were applied during the laser corneal refractive surgery process. | 2020-07-30 |
| 32724740 | A model for the Internal Medicine (IM) clerkship was developed incorporating a clinical telehealth component, in order to create a safe environment for students to continue to perform meaningful patient care. […] Students were instructed to complete the American College of Physicians (ACP) module on telehealth, given an orientation via the Zoom online platform by clinical faculty, and placed on a weekly telehealth clinic schedule, precepted by residents and attendings in IM. | 2020-07-30 |
| 32724831 | Here we review the cellular pathophysiology, clinical manifestations and treatment modalities of the cardiac manifestations seen in patients with COVID-19. | 2020-07-30 |
| 32725053 | to describe a COVID-19 cluster and the strategies used to contain the virus, in a municipality in the interior region of Mato Grosso state, Brazil. this is a descriptive study of documental records of an epidemiological investigation conducted in April 2020. introduction of SARS-CoV-2 in the municipality was identified through a cluster comprised of five people, 4 were symptomatic and 1 was asymptomatic, after the virus was imported by index cases C01 and C02; in addition to household transmission (C03, C04), a physiotherapist (C05) was infected through contact with C02; with the exception of C04, all had an influenza-like symptoms and C02 required hospitalization; as for laboratory tests, all were seroreactive and C01 was RT-PCR positive. dissemination of COVID-19 was contained by effective home isolation, an important instrument that should be adopted early by unaffected municipalities to contain virus dissemination, as well as by serological testing that detected infection in asymptomatic patients. | 2020-07-30 |
| 32725080 | The scientific effort to understand and control SARS-CoV-2 transmission and clinical impact has been huge, and important achievements are highlighted in this review. […] Instrumental to that is the quality of the data, relying on serological and molecular surveys in addition to trustworthy clinical records. […] Several candidate drugs are under evaluation in clinical trials. | 2020-07-30 |
| 32725156 | In response to the pandemic, the National Institute for Health and Care Excellence published guidance that employs the Clinical Frailty Scale (CFS) in a decision-making flowchart to assist clinicians in assessing older individuals’ suitability for critical care. | 2020-07-30 |
| 32725271 | Strict clinical assessment is paramount to detect suspicious cases. […] We consider that OTD needs to be included in clinical screening questionnaires in HCW. | 2020-07-30 |
| 32725286 | Furthermore, the reported efficacy of NTZ to bronchodilate the extremely contracted airways can be beneficial in alleviating COVID-19-associated symptoms. […] All these findings, along with the high safety record of the drug, have gained our interest to urge conductance of clinical trials to assess the potential benefits of using it in COVID-19 patients. […] Thus, in this summarized article, we review the antiviral activities of NTZ and highlight its promising therapeutic actions that make the drug worth clinical trials. | 2020-07-30 |
| 32725312 | They underwent a clinical and neurological evaluation and completed the State-Trait Anxiety Inventory (STAI-Y1), the Beck Depression Inventory second edition (BDI-II), and Multiple Sclerosis Quality of Life-54 (MsQoL-54) at T0 and T1. | 2020-07-30 |
| 32725351 | A large number of reports have explained the clinical characteristics and treatment strategies of COVID-19, but the characteristics and treatment of COVID-19 patient with systemic lupus erythematosus (SLE) are still unclear. […] Here, we report the clinical features and treatment of the first SLE patient with confirmed COVID-19 pneumonia. […] This was a 39-year-old woman, diagnosed with SLE 15 years ago, whose overall clinical characteristics (symptoms, laboratory tests, and chest CTs) were similar to those of the general COVID-19 patients. | 2020-07-30 |
| 32725382 | We found promising in vitro evidence for remdesivir, (hydroxy)chloroquine and favipiravir against SARS-CoV-2; potential clinical benefit in SARS-CoV-2 with remdesivir, the combination of lopinavir/ritonavir (LPV/r) plus ribavirin; and strong evidence for LPV/r plus ribavirin against Middle East Respiratory Syndrome (MERS) for post-exposure prophylaxis in healthcare workers. […] Despite these emerging data, robust controlled clinical trials assessing patient-centred outcomes remain imperative and clinical data have already reduced expectations with regard to some drugs. | 2020-07-30 |
| 32725449 | The new “Severe Acute Respiratory Syndrome Coronavirus 2” (SARS-CoV-2) is one of the Respiratory viruses causing highly acute lethal pneumonia coronavirus disease 2019 (COVID-19) with clinical similarities to those reported in “Severe Acute Respiratory Syndrome Coronavirus”(SARS-CoV) and the “Middle East Respiratory Syndrome Coronavirus”(MERS-CoV) including neurological manifestation. […] To explain the neurological manifestation caused by SARS-CoV-2, we will present a literature review of 765 COVID-19 patients, in which 18% had neurological symptoms and complications, including encephalopathy, encephalitis and cerebrovascular pathologies, acute myelitis, and Guillain-Barré syndrome. […] Clinical studies describe anosmia or partial loss of the sense of smell as the most frequent symptom in COVID19 patients, suggesting that olfactory dysfunction and the initial ultrarapid immune responses could be a prognostic factor. | 2020-07-30 |
| 32725453 | The true prevalence and clinical significance of underlying chronic liver diseases (CLD) in COVID-19 remains poorly defined. […] In this systematic review and meta-analysis, we included 74 clinical studies that were identified after a thorough literature search across three databases. […] To date, the clinical importance of chronic liver diseases among COVID-19 infection has remained undefined. | 2020-07-30 |
| 32725482 | Patients infected with COVID-19 most commonly present with respiratory tract symptoms and pneumonia. […] Gastrointestinal symptoms can also occur in these patients. | 2020-07-30 |
| 32725536 | We aim to review available knowledge on correlations between SARS-COV-2 Ct values and patient- or healthcare-related outcomes to determine whether Ct values provide useful clinical information. […] Data were extracted from studies reporting on the presence or absence of an association between Ct values, or viral loads determined via Ct value, and clinical outcomes. […] Data suggest that lower Ct values may be associated with worse outcomes and that Ct values may be useful in predicting the clinical course and prognosis of patients with COVID-19; however, further studies are warranted to confirm clinical value. | 2020-07-30 |
| 32725545 | SARS-CoV-2 mirroring experimental animal brain studies, characterization of time-dependent and region-dependent spreading behaviours of coronaviruses, enlightening of pathological mechanisms after coronavirus infection using long-term animal models and clinical observations of patients having had COVID-19 infection are calling to develop both protective strategies and drug discoveries to avoid early and late coronavirus-induced functional brain disturbances, symptoms and eventually disorders. […] To fight SARS-CoV-2, it is an urgent need to enforce clinical, molecular biological, neurochemical and genetic research including brain-related studies on a worldwide harmonized basis. | 2020-07-30 |
| 32725595 | The aims of this study were to compare the clinical and echocardiographic characteristics of inpatients in the intensive-care unit (ICU) and non-ICU patients. | 2020-07-30 |
| 32725596 | We investigated the viral loads, therapies, clinical features, and immune responses in a 70-year patient tested positive for SARS-CoV-2 for 3 months. […] The patient exhibited the highest prevalence of abnormal indices of clinical features and immune responses at the first admission, including fever (38.3 ℃), decreased lymphocytes (0.83 × 109/L) and serum potassium (3.1 mmol/L), as well as elevated serum creatinine (115 µmol/L), urea (8.6 mmol/L), and C-reactive protein (80 mg/L). | 2020-07-30 |
| 32725597 | The aim of our study was to assess respiratory function at the time of clinical recovery and 6 weeks after discharge in patients surviving to COVID-19 pneumonia. […] At the time of clinical recovery, FEV1 (2.07 ± 0.72 L) and FVC (2.25 ± 0.86 L) were lower compared to lower limit of normality (LLN) values (2.56 ± 0.53 L, p = 0.004, and 3.31 ± 0.65 L, p < 0.001, respectively), while FEV1/FVC (0.94 ± 0.07) was higher compared to upper limit of normality (ULN) values (0.89 ± 0.01, p = 0.029). | 2020-07-30 |
| 32725691 | The present research aims to describe clinical characteristics and outcomes of COVID-19 patients with diabetes. […] Fever (47/54, 87.04%), dry cough (36/54, 66.67%), and expectoration (21/53, 39.62%) were among the top three symptoms. | 2020-07-30 |
| 32725744 | Here we described the clinical characteristics and outcomes from two patients-a female aged 40-year-old and an 83-year-old male-who were subjected to SARS-CoV-2 infection, with history of chronic renal insufficiency. | 2020-07-30 |
| 32725762 | Data on clinical and demographic features, maintenance treatment, disease course, and outcomes in individuals with IA (rheumatoid arthritis and spondyloarthritis) with symptomatic COVID-19 infection were prospectively assessed via web-based questionnaire followed by individual phone calls and electronic medical record review. | 2020-07-30 |
| 32725858 | Very-high-risk patients were defined as clinical presentation of heart failure, cardiac shock, cardiac arrest, recurrent chest pain, and life-threatening arrhythmias. | 2020-07-30 |
| 32725884 | We analysed the demographics, epidemiological characteristics, clinical features, signs and symptoms of the disease at the onset. […] Understanding the epidemiological characteristics, clinical characteristics, and diagnosis and treatment of the first patients in various countries are of great significance for the identification, prevention and control of COVID-19. | 2020-07-30 |
| 32725890 | Liver injury has been reported as a non-pulmonary manifestation of COVID-19 but characterization of liver test abnormalities and their association with clinical outcomes is incomplete. […] Clinical characteristics, liver tests (AST, ALT, ALP, TBIL, albumin) at three time points (pre-infection baseline, admission, peak hospitalization), and hospitalization outcomes (severe COVID-19, ICU admission, mechanical ventilation, death) were analyzed. […] Conclusion: Abnormal liver tests occur in most hospitalized patients with COVID-19 and may be associated with poorer clinical outcomes. | 2020-07-30 |
| 32725955 | Limited pediatric cases with coronavirus disease 2019 (COVID-19) have been reported and the clinical profiles regarding COVID-19 in children remain obscure. […] Our aim was to investigate the clinical characteristics of COVID-19 in children. […] Epidemiological, clinical, laboratory, and radiological data were collected and analyzed to compare by age. […] The main clinical features were mild symptoms including fever (64%), cough (35%), and rhinorrhea (16%), or no symptoms (15%). […] We identified 17 patients (15%) with multisystem inflammatory syndrome in children (MIS-C) manifesting with symptoms overlapping with, but distinct from, Kawasaki disease, including gastrointestinal symptoms, left ventricular systolic dysfunction, shock, and marked elevated inflammatory biomarkers. […] Early detection of children with mild symptoms or an asymptomatic state and early diagnosis of MIS-C are mandatory for the management of COVID-19 and the prevention of transmission and a severe inflammatory state. | 2020-07-30 |
| 32726003 | To scientifically evaluate the intervention effect of Chinese medicine preventive administration(combined use of Huo-xiang Zhengqi Oral Liquid and Jinhao Jiere Granules) on community population in the case of coronavirus disease 2019(COVID-19), a large cohort, prospective, randomized, and parallel-controlled clinical study was conducted. | 2020-07-30 |
| 32726004 | Traditional Chinese medicine(TCM) has both systematism theory knowledge and clinical practical value in the prevention and treatment of COVID-19. […] The patents for treatment of coronavirus mainly focused on the treatment of coronavirus, while the patents for symptomatic treatment mainly focuses on the improvement of respiratory symptoms, such as fever and cough. | 2020-07-30 |
| 32726006 | In this study, 45 prescriptions of Mongolian medicine for the prevention of COVID-19 were collec-ted and further analyzed, hoping to provide new ideas for clinical diagnosis and treatment. | 2020-07-30 |
| 32726008 | This study showed that the TCMATCOV platform could evaluate the disturbance effect of different prescriptions on the COVID-19 disease network, and predict potential effectiveness based on the robustness of drug-interfered pneumonia disease networks, so as to provide a reference for further experiments or clinical verification. | 2020-07-30 |
| 32726128 | The sex hormone estrogen interacts with the renin-angiotensin-aldosterone system, one of the most critical pathways in COVID-19 infectivity, and modulates the vasomotor homeostasis. | 2020-07-30 |
| 32726134 | The aim of this study was to describe clinical, imaging, and laboratory features of acute pulmonary embolism (APE) in patients with COVID-19 associated pneumonia. | 2020-07-30 |
| 32726140 | However, despite the existence of literally thousands of clinical trials, the management of COVID-19 remains challenging, and the development of an optimal, evidence-based therapeutic approach is ongoing. […] The purpose of this review article is therefore to provide a rapid, comprehensive, and relevant overview and primer on SARS-CoV-2 and COVID-19, with attention to the epidemiology, virology, transmission, clinical features, and major therapeutic options currently existent. | 2020-07-30 |
| 32726146 | We examine the clinical representation of VALI and the delve into the scientific evidence of how deadly exposure to electronic cigarettes can be. | 2020-07-30 |
| 32726155 | It is possible that cost of health care, doctor-patient relationships, and the clinical reasoning skills could be seriously impacted by ongoing decrease in bedside skills and the teaching of these skills. […] Careful history taking and hypothesis-driven physical examination still form the backbone of clinical reasoning and lead to parsimonious investigations. […] These strategies can be adapted to normal clinical teaching situations as well as challenging situations such as the current pandemic when physical distancing is mandated. | 2020-07-30 |
| 32726217 | The virus has the characteristics of strong transmission capacity, diverse clinical manifestations, long incubation period, and latent infection, thus posing a serious threat to human life safety and health. […] With the increasing number of cases and the continuous enrichment of clinical data, 2019-nCoV-infected patients have received more and more attention regarding myocardial injury related to virus infection besides typical respiratory system manifestations. | 2020-07-30 |
| 32726230 | A recent case report reported improvement of clinical symptoms with remdesivir in a patient with COVID-19. […] After conducting a systematic search of 18 clinical trial registries and three large scientific databases, we identified 86 potentially eligible items. […] A total of seven ongoing and recruiting clinical trials of remdesivir (100-200 milligrams, intravenous [IV]) were included. […] We identified the following primary outcomes: patients discharged (n = 2); time to clinical status improvement (n = 2); improved O2 saturation (n = 2); body temperature normalization (n = 2); and clinical status (n = 1). […] Therefore, despite supportive data from in vitro and in vivo studies, the clinical effectiveness of IV remdesivir for treatment of COVID-19 and potential side effects remain incompletely defined in the human population. | 2020-07-30 |
| 32726235 | Future studies examining the clinical characteristics and risk factors of COVID-19 patients across large, diverse populations will strengthen our understanding of this novel and complex disease. | 2020-07-30 |
| 32726239 | A multidisciplinary, team-based approach to the development and training of a standardized intubation algorithm combining simulation and rapid-cycle improvement methodology is a useful, effective process to respond to rapidly evolving clinical information and experiences during a global pandemic. | 2020-07-30 |
| 32726240 | If generalizable, future directions would include defining how to incorporate LUS into clinical management and its role in screening lower-risk populations. | 2020-07-30 |
| 32726244 | On behalf of the American Association for Emergency Psychiatry, we highlight unique considerations for patients with severe behavioral symptoms and staff members managing symptoms of agitation during COVID-19. | 2020-07-30 |
| 32726291 | Methods We analysed routine data for the period November 2019 through May 2020 from three sources: (1) from the Slovenian Cancer Registry we analysed data on pathohistological and clinical practice cancer notifications from two major cancer centres in Ljubljana and Maribor; (2) from the e-referral system we analysed data on all referrals in Slovenia issued for oncological services, stratified by type of referral; and (3) from the administrative data of the Institute of Oncology Ljubljana we analysed data on outpatient visits by type as well as on diagnostic imaging performed. […] Results Compared to the November 2019 - February 2020 average, the decrease in April 2020 was about 43% and 29% for pathohistological and clinical cancer notifications; 33%, 46% and 85% for first, control and genetic counselling referrals; 19% (53%), 43% (72%) and 20% (21%) for first (and control) outpatient visits at the radiotherapy, surgery and medical oncology sectors at the Institute of Oncology Ljubljana, and 48%, 76%, and 42% for X-rays, mammograms and ultrasounds performed at the Institute, respectively. | 2020-07-30 |
| 32726296 | Descriptive evaluation of radiologic findings was performed using a classification based on the time interval between the initiation of the symptoms and chest CT-scan. […] The median age of patients was 58.0 years, and the median time interval from the onset of symptoms to CT scan evaluation was 7 days. […] We also found that as the time interval between symptoms and CT scan evaluation increased, the predominant pattern changed from GGO to mixed pattern and then to elongated-containing and band-like-opacities-containing pattern; on the other hand, the percentage of lung involvement increased. […] However, these patterns might change according to the time interval from symptoms. | 2020-07-30 |
| 32726355 | While awaiting the results of the many clinical trials that are evaluating the efficacy of IFN-I alone or in combination with antiviral molecules, we discuss the potential benefits of a well-timed IFN-I treatment and propose strategies to boost pDC-mediated IFN responses during the early stages of viral infection. | 2020-07-30 |
| 32726417 | SARS-CoV-2 infection was found in hospital personnel (n = 24), who developed mild symptoms necessitating leave of absence and self-isolation, but not hospitalization; 75% developed antibodies, but with low/absent virus neutralization (60% with titers <1:20). | 2020-07-30 |
| 32726515 | According to the categorisation of Beck Anxiety Inventory scores 8.6% showed severe anxiety symptoms. | 2020-07-30 |
| 32726561 | Patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) typically undergo frequent clinical evaluation. | 2020-07-30 |
| 32726723 | This study investigated, using cycle threshold (Ct) qPCR values, the association between symptoms and viral clearance in 57 patients with asymptomatic/mild SARS-CoV-2 infection. | 2020-07-30 |
| 32726724 | This study aimed to describe the effectiveness and optimum use of tocilizumab (TCZ) treatment by the support of clinical, laboratory and radiologic observations. […] Disease course of the patients was grouped as severe or critical, according to their clinical, laboratory and radiologic evaluations. | 2020-07-30 |
| 32726792 | A total of 22 patients came from home and 8 patients were admitted to the emergency room for urgent neurological symptoms. […] GKRS improved symptoms and reduced the need for open surgeries, allowing many patients to continue their therapeutic path and sparing beds in ICUs. | 2020-07-30 |
| 32726801 | Clinical manifestations of COVID-19 vary, ranging from asymptomatic infection to respiratory failure. […] The effect of pre-existing SARS-CoV-2 cross-reactive T cells on clinical outcomes remains to be determined in larger cohorts. | 2020-07-30 |
| 32726868 | Advanced age, comorbidities, abnormal inflammatory and organ injury circulating biomarkers captured patients with an adverse clinical outcome. […] Clinical history and laboratory profile may then help identify patients with a higher risk of in-hospital mortality. | 2020-07-30 |
| 32726951 | However, this conclusion might be biased, because, in some studies, the patients in the steroid group had more severe symptoms than those in the control group. | 2020-07-31 |
| 32727107 | Treatment of acute respiratory distress syndrome (ARDS) due to COVID-19 pneumonia (CARDS) represents a clinical challenge, requiring often invasive mechanical ventilation (IMV). […] Despite treatment with antiviral and non-invasive ventilation (NIV), after 24 h there was a progressive worsening of clinical conditions with higher fever (40 °C), increased dyspnea, and hypoxia (PaO2/FiO2 or P/F ratio of 150). […] After only 96 h, the clinical, laboratory, and imaging findings showed incredible improvement. | 2020-07-31 |
| 32727142 | Measurements from a network of air quality sensors gathered during a clinical study provide validation for the main part of the model. […] To address the clinical implication over a long period of time, the systems approach is built upon previous work on multi-scale modeling of surgical flow in a large operating room suite and takes into account human behavior factors. | 2020-07-31 |
| 32727145 | Though there is growing knowledge of the SARS-CoV2 infection and its clinical manifestations, an effective cure to limit its acute symptoms and its severe complications has not yet been found. […] These PDE inhibitors have already been used in the treatment of pathologies that show clinical signs and symptoms completely or partially overlapping with post-COVID-19 conditions (e.g., thrombosis, inflammation, fibrosis), while new PDE-selective or pan-selective inhibitors are currently under study. | 2020-07-31 |
| 32727175 | Objective: To analyze the clinical features and death-related risk factors of COVID-19. […] We compared the demographics, laboratory findings, clinical characteristics, treatments and prognosis data of the 582 severe patients. […] Conclusions: The average onset time of severe COVID-19 was 8 days, and the most common symptoms were fever, dry cough and fatigue. | 2020-07-31 |
| 32727176 | Objective: To analyze the epidemiological and clinical characteristics, and imaging features of patients with COVID-19 in Henan Province People’s Hospital. […] Methods: The epidemiology, clinical symptoms, laboratory and radiologic data of 49 patients with COVID-19 infection admitted to the department of infectious disease in our hospital from January 23, 2020 to February 22, 2020 were retrospectively analyzed. […] Common symptoms at the onset were fever (41 patients), dry cough (35 patients), and fatigue (21 patients). […] The clinical symptoms were mainly fever and dry cough. | 2020-07-31 |
| 32727177 | Clinical data of the two groups were collected and compared, including general information, laboratory examinations, imaging features and treatments. | 2020-07-31 |
| 32727305 | Clinical characteristics, reperfusion therapy modalities, COVID-19 status and in-hospital mortality of consecutive STEMI patients who were admitted to Belgian hospitals for percutaneous coronary intervention (PCI) were recorded during a three-week period starting at the beginning of the lockdown period on 13 March 2020. | 2020-07-31 |
| 32727345 | We aimed to analyze which symptoms and laboratory abnormalities were associated with the presence of headache and to evaluate if patients with headache had a higher adjusted in-hospital risk of mortality. […] We collected demographic data, clinical variables and laboratory abnormalities. | 2020-07-31 |
| 32727456 | We aimed to report the epidemiological and clinical characteristics of hospitalized patients with coronavirus disease-19 (COVID-19) in Zengdu District, Hubei Province, China. […] Clinical data on COVID-19 inpatients in Zengdu Hospital from January 27 to March 11, 2020 were collected; this is a community hospital in an area surrounding Wuhan and supported by volunteer doctors. […] The epidemiological findings, clinical features, laboratory findings, radiologic manifestations, and clinical outcomes of these patients were analyzed. […] The patients were followed up for clinical outcomes until March 22, 2020. […] Common symptoms included fever (82.2% [227/276]) and cough (78.0% [218/276]). | 2020-07-31 |
| 32727465 | Demographic characteristics, symptoms, signs, underlying diseases, and laboratory data were collected. | 2020-07-31 |
| 32727486 | Prior studies have focused mainly on clinical risk factors associated with serious illness and mortality of COVID-19. […] Less analysis has been conducted on the clinical, sociodemographic, and environmental variables associated with initial infection of COVID-19. […] Publicly available data were utilized as approximations for social determinants of health, and patient-level clinical and sociodemographic factors were extracted from the electronic medical record. | 2020-07-31 |
| 32727613 | As secondary objectives, we would like to: i) assess the efficacy of the use of PrEP with hydroxychloroquine against placebo in healthcare workers with high risk of SARS-CoV-2 infection in reducing their risk of exposure to SARS-CoV-2 (defined by seroconversion) during an epidemic period, ii) evaluate the safety of PrEP with hydroxychloroquine in adults, iii) describe the incidence of SARS-CoV-2 infection among healthcare workers at high risk of SARS-CoV-2 infection, iv) identify clinical, analytical and microbiological predictors of COVID-19 among healthcare workers at high risk of SARS-CoV-2 infection, v) set up a repository of serum samples obtained from healthcare workers at high risk of SARS-CoV-2 infection for future research on blood markers to predict SARS-CoV-2 infection. […] Multicentre double-blind parallel design (ratio 1:1) randomized controlled clinical trial. […] The primary endpoint will be the number of confirmed cases of a COVID-19 (defined by a positive PCR for SARS-CoV-2 or symptoms compatible with COVID-19 with seroconversion) in the PrEP group compared to the placebo group at any time during the 6 months of the follow-up in healthcare workers with negative SARS-CoV-2 PCR and serology at day 0. […] As secondary endpoints, we will obtain: i) the SARS-CoV-2 seroconversion in the PrEP group compared to placebo during the 6 months of follow-up in healthcare workers with negative serology at day 0; ii) the occurrence of any adverse event related with hydroxychloroquine treatment; iii) the incidence of SARS-CoV-2 infection and COVID-19 among healthcare workers in the non-PrEP group, among the total of healthcare workers included in the non-PrEP group during the study period; iv) the risk ratio for the different clinical, analytical and microbiological conditions to develop COVID-19; v) a repository of serum samples obtained from healthcare workers confirmed COVID-19 cases for future research on blood markers to predict SARS-CoV-2 infection. | 2020-07-31 |
| 32727624 | Set-up and therapy titration is not protocolised and is delivered in accordance with clinical discretion. […] Set-up and therapy titration is not protocolised and is delivered in accordance with clinical discretion. […] Set-up and therapy titration is not protocolised and is delivered in accordance with clinical discretion. […] Intervention delivery continues up to the point of death, tracheal intubation, or clinical determination that there is no ongoing need (palliation or improvement). […] The nature of the trial interventions precludes blinding of the researcher, patient and clinical team. […] The study protocol has been reported in accordance with the Standard Protocol Items: Recommendations for Clinical Interventional Trials (SPIRIT) guidelines (Additional file 2). | 2020-07-31 |
| 32727740 | The use of clinical codes could misrepresent the true occurrence of the disease. | 2020-07-31 |
| 32727811 | Throughout the clinical progression of the disease, SARS-CoV-2 could not be cleared due to his humoral immunodeficient state. | 2020-07-31 |
| 32727828 | In this study, we report the analytical and clinical performance characteristics of a new, high-throughput, fully automated nucleic acid amplification test system for the detection of SARS-CoV-2. […] Clinical nasopharyngeal swab specimen testing (n = 140) showed 100%, 98.7%, and 99.3% positive, negative, and overall agreement, respectively, with a validated reverse transcription-PCR nucleic acid amplification test (NAAT) for SARS-CoV-2 RNA. | 2020-07-31 |
| 32727884 | Continued serologic surveillance among pregnant women may inform perinatal clinical practices and can potentially be used to estimate exposure to SARS-CoV-2 within the community. | 2020-07-31 |
| 32728006 | The neonatal clinical manifestations of COVID-19 commonly included shortness of breath (6%), gastrointestinal symptoms (4%), and fever (3%). | 2020-07-31 |
| 32728473 | Our suggestions have not been specifically evaluated in the clinical environment. | 2020-07-31 |
| 32728498 | The parameters that successfully model the pandemic are: the basic reproduction number R0, 4.4; a latent non-infectious period of 1.1. days followed by 4.6 days of the presymptomatic infectious period; the probability of developing severe symptoms, 0.01; the probability of being diagnosed when presenting severe symptoms of 0.6; the probability of diagnosis for cases with mild symptoms or asymptomatic, 0.001. | 2020-07-31 |
| 32728768 | In such situations, prioritisations should be based on the criterion of clinical prospect of success in order to minimize the number of preventable deaths due to resource scarcity and to avoid discrimination based on age, disabilities or social factors. […] The assessment of the clinical prospect of success should take into account the severity of the current illness, severe comorbidities and the patient’s general health status prior to the current illness. | 2020-07-31 |
| 32728769 | In such situations, prioritisations should be based on the criterion of clinical prospect of success in order to minimize the number of preventable deaths due to resource scarcity and to avoid discrimination based on age, disabilities or social factors. […] Assessment of the clinical prospect of success should take into account the severity of the current illness, severe comorbidities and the patient’s general health status prior to the current illness. | 2020-07-31 |
| 32728799 | Review of clinical examination, and whole-brain voxel-based analysis of 18F-FDG PET metabolism in comparison with healthy subjects (p voxel < 0.001, p-cluster < 0.05, uncorrected), of two patients with confirmed diagnosis of SARS-CoV-2 explored at the post-viral stage of the disease. […] Post-viral cohort studies are required to specify the exact relationship between such hypometabolisms and the possible persistent disorders, especially involving cognitive or emotion disturbances, residual respiratory symptoms, or painful complaints. | 2020-07-31 |
| 32728817 | This is followed by a description of symptoms, which develop in three phases. | 2020-07-31 |
| 32728901 | We reviewed the medical records of children with COVID-19 who were admitted Feb. 25 to May 1, 2020. […] We reviewed patient demographics, symptoms, comorbidities, requirement for respiratory support, evidence of acute myocardial injury, and chest radiographs. […] Presenting symptoms included fever (89%), cough (68%), respiratory distress (68%) and vomiting/diarrhea (47%). | 2020-07-31 |
| 32728965 | We examined the clinical features, ventilatory management, and clinical outcomes of COVID-19 ARDS patients, and compared some results with other relevant studies in non-COVID-19 ARDS patients. | 2020-07-31 |
| 32728966 | LUS score was significantly associated with pneumonia severity assessed by chest CT and clinical features. […] In known SARS-CoV-2 pneumonia patients, the LUS score was predictive of pneumonia severity as assessed by a chest CT scan and clinical features. | 2020-07-31 |
| 32728975 | Such practice has an effect on the lower incidence, intensity of symptoms and mortality in viral infections observed in people who practice physical activity regularly, and its correct execution must be considered to avoid damage. | 2020-07-31 |
| 32729111 | The advance of telemedicine will depend on the implementation of technology, on solving legal and security/privacy issues, on its clinical outcomes and on the extent to which patients demand and accept these virtual visits. | 2020-07-31 |
| 32729139 | To present the adaptations to treatment protocols made in a child and adolescent eating disorders (ED) unit during the eight-week confinement period mandated in response to the COVID-19 pandemic and examine clinical and treatment variables in the outpatient, day hospital, and inpatient care programs. […] Retrospective review of medical records and analysis of general and specific variables related to the pandemic and confinement. […] Almost half of the children and adolescents studied experienced reactivation of ED symptoms despite treatment, and severe patients (25%) presented self-harm and suicide risk. | 2020-07-31 |
| 32729142 | Clinical characteristics and outcomes of vulnerable populations, such as those with gynecologic cancer who develop COVID-19 infections, is limited. […] Demographic and clinical outcome data were abstracted through a review of electronic medical records. | 2020-07-31 |
| 32729192 | To compare the clinical features of Middle East respiratory syndrome coronavirus (MERS-CoV) infection between paediatric and adult cases. […] Age-specific differences in the clinical presentation of MERS-CoV cases could have implications for transmission for other betacoronaviruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). | 2020-07-31 |
| 32729248 | Recent studies have suggested that patients with hypertension and diabetes treated with ACE inhibitors (ACEIs) or angiotensin receptor blockers have a higher risk of COVID-19 infection as these drugs could upregulate ACE2, motivating the study of ACE2 modulation by drugs in current clinical use. | 2020-07-31 |
| 32729278 | Clinical and laboratory findings were compared between groups, and predictors of positive conversion were investigated. | 2020-07-31 |
| 32729288 | There are few descriptions of the clinical presentation and evolution of consecutive SARS-CoV-2 infections with a long-enough follow up. […] The most common symptoms at the time of diagnosis were fever (80.0%), cough (53.0%) and dyspnea (23.0%). | 2020-07-31 |
| 32729312 | The most common psychological responses across these subpopulations were anxiety (overall range 24.8%-49.5%), depression (overall range 18.6%-42.6%) and traumatic stress symptoms (overall range 12.7%-31.6%). | 2020-07-31 |
| 32729363 | We have summarized and analyzed the clinical trial registration status and the latest research progress of eight major antiviral drugs during the epidemic of Coronavirus Disease 2019 (COVID-19), which can provide reference methods for clinical formulation of the best antiviral treatment. […] We used the generic names of 8 antiviral drugs as keywords to search and analyze the COVID-19-related clinical trials registered in Chinese Clinical Trial Registry and ClinicalTrials.gov. […] Then, we used the keywords to obtain and summarize their clinical research results related to COVID-19 in CNKI, WANFANG, CQVIP, and PubMed database. […] The registration system of clinical trials and the level of clinical trial design need to be further improved. […] At present, no specific drug has been found for the treatment of COVID-19, the efficacy of antiviral drugs mostly comes from small sample studies or retrospective studies, and the level of clinical evidence is low. | 2020-07-31 |
| 32729367 | Several clinical trials are being conducted today to evaluate vaccines against the virus. […] The aim of our present review is to furnish brief details about the statistics, diagnosis, epidemiology, pathogenesis, prevention and treatment of COVID-19 to assist researchers and the society at large to come to grip with the deadly disease.HighlightsCumbersome outbreak of the novel Coronavirus Disease 2019 (COVID-19) became a pandemicAt June 19, 2020, as per WHO report 8,618,787 infected cases and 457,275 dead were recorded globallyMajor spread was found to be human to human transmissionsPeople with positive COVID-19 were infected with severe respiratory syndromeMore animal and clinical studies have to be done to overcome this pandemic. | 2020-07-31 |
| 32729370 | The efficacy of some promising antivirals needs to be investigated by ongoing clinical trials. | 2020-07-31 |
| 32729428 | Mesenchyma stem cells (MSCs) based treatment has the advantage of targeting numerous pathophysiological components of ARDS by secreting a series of cell factors, exerting anti-inflammatory, antioxidative, immunomodulatory, antiapoptotic, and proangiogenic effects, resulting in significant structural and functional recovery following ARDS in various preclinical models. […] And recently pilot clinical studies indicated MSCs based therapy was promise in treatment of ARDS caused by SARS-CoV-2. | 2020-07-31 |
| 32729433 | The potential ocular presence of the SARS-CoV-2 in the eye of a patient can target ACE2 receptors in the endothelium of the conjunctival vessels and use the lacrimal sac a potential space to evade immune detection and clinical isolation. | 2020-07-31 |
| 32729441 | To prevent nosocomial transmission of the disease, we subsequently isolated patients with suspected symptoms, relevant radiographic findings, or epidemiology. | 2020-07-31 |
| 32729494 | In this review, sequentially, we have provided the clinical details along with genetic and proteomic biomarkers related to COVID-19. […] The critical insights on the developer, commercial brand name, detection methods, technical operational details, detection time, clinical specimen, status, the limit of detection/detection ability have been discussed comprehensively. | 2020-07-31 |
| 32729548 | Comparing the results of the sensor with clinical diagnostics of more than 140 normal and involved cases resulted in a response calibration with accuracy and sensitivity both 97%. | 2020-07-31 |
| 32729810 | This study retrospectively included patients who received an unenhanced chest CT scan due to clinical suspicion of COVID-19 at two medical centers. | 2020-07-31 |
| 32729823 | Therefore, clinical pharmacist should participate in the optimization of drug treatment programs. […] Clinical pharmacists should participate in the optimization of drug treatment programs and provide pharmaceutical care for critically ill COVID-19 patients; this can promote the rational use of drugs. | 2020-07-31 |
| 32729849 | Eleven (26.8%) patients, including 6 neonates, never showed any symptoms. | 2020-07-31 |
| 32729850 | To assess the epidemiological and clinical characteristics of pediatric inpatients with COVID-19, early in the pandemic. […] Clinical and laboratory profile and outcomes were studied for children (aged 1 month - 18 years) presenting between 1 April, 2020 and 20 May, 2020 with positive nasopharyngeal swab for SARS-CoV-2 by RT-PCR. 50 children (56% male) with median (IQR) age of 6 (2-12) years were included. […] Majority (56%) were from families belonging to Kuppuswamy upper lower socioeconomic class. 45 (90%) had positive household contact, and 33 (66%) had overcrowding at home. 29 (58%) children were asymptomatic while 20 (40%) had mild symptoms. […] Fever, cough, and sore throat were the most common symptoms. | 2020-07-31 |
| 32729939 | There is currently very limited information on the nature and prevalence of post-COVID-19 symptoms after hospital discharge. […] A purposive sample of 100 survivors discharged from a large University hospital were assessed 4 to 8 weeks after discharge by a multidisciplinary team of rehabilitation professionals using a specialist telephone screening tool designed to capture symptoms and impact on daily life. […] The next most common symptoms were breathlessness (65.6% in ICU group and 42.6% in ward group) and psychological distress (46.9% in ICU group and 23.5% in ward group). […] This is the first study from the United Kingdom reporting on postdischarge symptoms. […] We recommend planning rehabilitation services to manage these symptoms appropriately and maximize the functional return of COVID-19 survivors. | 2020-07-31 |
| 32730095 | In this detailed review, we have discussed the structure of SARS-CoV-2, essential proteins, its lifecycle, transmission, symptoms, pathology, clinical features, diagnosis, prevention, treatment and epidemiology of the disease. | 2020-07-31 |
| 32730110 | Chest X-ray should often be sufficient in children avoiding additional irradiation, chest CT needs only be done in cases of clinical necessity. | 2020-07-31 |
| 32730160 | No clinical study has yet reported the viral load in the aerosol and therefore the infective dose has not been accurately determined. | 2020-07-31 |
| 32730205 | This review analyzes the epidemiology, etiology, clinical characteristics, treatment and sequelae of the severe acute respiratory syndrome (SARS), the Middle East respiratory syndrome (MERS) and the 2019 novel coronavirus disease (COVID-19) to help provide direction for further studies that can help understand COVID-19. | 2020-07-31 |
| 32730210 | Moreover, the proposed method can be easily extended to other similar clinical applications such as computer-aided detection and diagnosis of pulmonary nodules in CT images, glaucoma lesions in Retina fundus images, etc. | 2020-07-31 |
| 32730222 | Mixed-reality (MR) technology is the latest iteration of telemedicine innovation; it is a logical next step in the move toward the provision of digitally supported clinical care and medical education. […] A prospective, observational, nested cohort evaluation of the HoloLens2 was undertaken across three distinct clinical clusters in a teaching hospital in the United Kingdom. […] Data pertaining to staff exposure to high-risk COVID-19 environments and personal protective equipment (PPE) use by clinical staff (N=28) were collected, and assessments of acceptability and feasibility were conducted. […] In total, 89.3% (25/28) of users felt that their clinical team was safer when using the HoloLens2. […] Deploying such technologies at pace requires context-specific information security, infection control, user experience, and workflow integration to be addressed at the outset and led by clinical end-users. | 2020-07-31 |
| 32730223 | Therefore, NLR can be adopted as a prognostic tool to assist healthcare providers predict the clinical outcomes of older patients suffering from COVID-19. | 2020-07-31 |
| 32730226 | In this issue of the JCI, Lee and Day-Lewis et al. and Diorio et al. explored the clinical profiles associated with coronavirus disease 2019 in children. […] We posit that while splitting MIS-C into a separate disease may aid clinical management decisions, lumping it into the KD pot may better serve to understand pathobiology. | 2020-07-31 |
| 32730233 | Cytokine profiles, viral cycle thresholds (Cts), blood smears, and soluble C5b-9 values were analyzed with clinical data.RESULTSTwenty patients were enrolled (9 severe COVID-19, 5 minimal COVID-19, and 6 MIS-C). […] FUNDINGFinancial support for this project was provided by CHOP Frontiers Program Immune Dysregulation Team; National Institute of Allergy and Infectious Diseases; National Cancer Institute; the Leukemia and Lymphoma Society; Cookies for Kids Cancer; Alex’s Lemonade Stand Foundation for Childhood Cancer; Children’s Oncology Group; Stand UP 2 Cancer; Team Connor; the Kate Amato Foundations; Burroughs Wellcome Fund CAMS; the Clinical Immunology Society; the American Academy of Allergy, Asthma, and Immunology; and the Institute for Translational Medicine and Therapeutics. | 2020-07-31 |
| 32730234 | CASE REPORT We describe the case of an 8-year-old boy admitted with status epilepticus, who also tested positive for COVID-19, while afebrile, with no initial respiratory symptoms. […] All clinical symptoms resolved within a few hours. | 2020-07-31 |
| 32730238 | Respondents were asked about demographic characteristics, baseline chronic medical conditions, symptoms present at the time of testing, whether those symptoms had resolved by the interview date, and whether they had returned to their usual state of health at the time of interview. […] Among 292 respondents, 94% (274) reported experiencing one or more symptoms at the time of testing; 35% of these symptomatic respondents reported not having returned to their usual state of health by the date of the interview (median = 16 days from testing date), including 26% among those aged 18-34 years, 32% among those aged 35-49 years, and 47% among those aged ≥50 years. […] Among respondents reporting cough, fatigue, or shortness of breath at the time of testing, 43%, 35%, and 29%, respectively, continued to experience these symptoms at the time of the interview. | 2020-07-31 |
| 32730358 | This study aimed to develop risk scores based on clinical characteristics at presentation to predict intensive care unit (ICU) admission and mortality in COVID-19 patients. 641 hospitalized patients with laboratory-confirmed COVID-19 were selected from 4997 persons under investigation. […] We performed a retrospective review of medical records of demographics, comorbidities and laboratory tests at the initial presentation. […] Logistic regression was used to identify independent clinical variables predicting the two outcomes. […] This study identified key independent clinical variables that predicted ICU admission and mortality associated with COVID-19. […] This risk score system may prove useful for frontline physicians in clinical decision-making under time-sensitive and resource-constrained environment. | 2020-07-31 |
| 32730385 | The catastrophic emergency experienced by many countries with the COVID-19 pandemic emphasized the importance of bioethics for decision-making, both at the public health (equitable and effective policies) and at the clinical level. […] At the clinical level, the issues are the fulfillment of medical care demand with adequate health care teams, infrastructure, and supplies, and to cover critical care demands that surpass the available resources. | 2020-07-31 |
| 32730512 | In this article, we present the current knowledge about the role of RAAS in coronavirus infection, based on physiopathological concepts, molecular bases, and experimental and clinical evidence. | 2020-07-31 |
| 32730678 | In this study, we aimed to evaluate the clinical findings, laboratory parameters, and prognosis of COVID-19 disease in end-stage renal patients undergoing hemodialysis treatment. […] The demographic characteristics, comorbidities, symptoms, clinical course, laboratory parameters, and treatments were recorded. […] The most common symptoms were dyspnea (56%) and fever (52%). […] The associated clinical symptoms of COVID-19 were similar in hemodialysis patients to those of patients without renal disease. | 2020-07-31 |
| 32730771 | Clinical staff had a higher rate of laboratory-confirmed COVID-19 than non-clinical staff, but total sickness rates were similar. […] Sustained transmission of SARS-CoV-2 among our hospital staff did not occur, beyond the community outbreak, even in the absence of strict infection control measures in non-clinical areas. […] Our findings emphasize the importance of testing both clinical and non-clinical staff groups during a pandemic. | 2020-07-31 |
| 32730827 | Clinical data and the results of nasopharyngeal specimen and serum antibody testing were also collected for the patient sample. | 2020-07-31 |
| 32730915 | In addition, there are studies showing that certain psychopathological symptoms might appear in infected patients, including those related to mood and psychotic disorders as well as post-traumatic stress disorder. | 2020-07-31 |
| 32730951 | PalliCOVID features evidence-based clinical guidelines, educational content, and institutional protocols related to palliative care for COVID-19 patients. […] The quantitative data presented here, although informative about user behavior, should be supplemented with future qualitative research to further define the impact of this tool and extend our ability to deliver clinical care that is compassionate, rational, and well-aligned with patients’ values and goals. | 2020-07-31 |
| 32730975 | General demographics, clinical status, mechanism of trauma, diagnosis, and treatment instituted were recorded. | 2020-07-31 |
| 32731057 | A proforma was created to capture key patient demographics, indication for admission and presence of SARS-CoV-2 related symptoms at the point of presentation. | 2020-07-31 |
| 32731090 | The clinical presentation of the SARS-CoV-2 varies between a subclinical or flu-like syndrome to that of severe pneumonia with multi-organ failure and death. | 2020-07-31 |
| 32731151 | A total of 71 patients with suspected COVID-19 were selected to participate in this study, which included a retrospective analysis of clinical features, imaging examination, laboratory biochemical examination and nucleic acid detection and specific antibody (IgM and IgG) detection. | 2020-07-31 |
| 32731192 | Lessons learned from the experience with the introduction of antibody tests for HIV are highlighted.Each test will need to be separately vetted for performance and clinical implementation based upon rigorous clinical trial data. | 2020-07-31 |
| 32731215 | In this report, we describe the clinical characteristics, presentations, clinical course, and outcomes of ESKD patients on PD hospitalized with COVID-19. | 2020-07-31 |
| 32731257 | S, is currently being evaluated in clinical trials. | 2020-07-31 |
| 32731258 | The safety, immunogenicity and efficacy profiles of ChAdOx1 nCoV-19 against symptomatic PCR-positive COVID-19 disease will now be assessed in randomized controlled clinical trials in humans. | 2020-07-31 |
| 32731275 | COVID 19, caused by SARS-CoV2, a new variant of coronaviruses, typically presents with respiratory symptoms. […] However, in a significat number of patients different organs are involved in the disease, often including gastrointestinal symptoms. […] Because viral RNA can be detected in fecal samples, some implications for clinical routine in diagnostic and therapeutic procedures are grown. | 2020-07-31 |
| 32731277 | Infection with SARS-COV-2 leads to a number of pathologies in the hematopoetic system that have significant impact on clinical symptoms and mortality. […] There are 3 stages of infection: (1) early upper respiratory tract infection with fever and lymphopenia (2) pulmonary phase and (3) hyperinflammatory phase with the clinical signs of organ failure such as ARDS/shock. […] In analogy to the cytokine release syndrome (CRS) after CAR-T cell therapy, the therapeutic activity of the IL-6 receptor antibody tocilizumab is investigated in clinical studies.The coagulation system is activated during the inflammatory phase of COVID infection, most likely on the pathophysiological basis of immune thrombosis. […] Its administration has shown promising activity in first uncontrolled case series and is currently being examined in clinical studies worldwide for its therapeutic activity. | 2020-07-31 |
| 32731279 | Ideally, a cohort isolation is implemented.Monitoring of patients with COVID-19 is not different from other intensive care patients and should be adapted to the clinical situation of the individual patient. | 2020-07-31 |
| 32731281 | Increasing insight into the clinical phenotype and mechanisms of SARS-CoV-2 infections and COVID-19 has identified damage of the kidneys as a key player in the course of the disease. | 2020-07-31 |
| 32731285 | However, the findings of pulmonary sonography must be placed in the clinical context; sonography does not replace the gold standard of PCR diagnosis. | 2020-07-31 |
| 32731725 | Other members of the travel group also fell ill, but only showed flu-like symptoms. | 2020-08-01 |
| 32731751 | Of 47 patients who returned, 23 (48.9%) developed new symptoms, 21 (44.6%) had stone growth, and 3 defaulted to face-to-face appointment. | 2020-08-01 |
| 32731783 | There is a global problem of increment of the number of children with clinical features that mimic Kawasaki Disease (KD) during the ongoing Coronavirus Disease 2019 (COVID-19) pandemic. […] The complexity of symptoms was defined as an «acute febrile mucocutaneous lymphnode syndrome". […] However, it is believed that COVID-19 virus infection worsens the course of Kawasaki disease, and in some cases, children affected by SARS-V-2 may develop a disease that has a clinical picture similar to Kawasaki disease. | 2020-08-01 |
| 32731864 | This research aims to examine the psychological effects of social quarantine on the psychotic phenotype and pseudoscientific beliefs-experiences of the general nonclinical population. […] Significant differences were obtained for the variables positive psychotic symptoms, depressive symptoms, and certain perceptual alterations (e.g., cenesthetic perceptions), and a significant increase in pseudoscientific beliefs was also observed. […] Measures taken after quarantine indicate that perceptual disturbances, subclinical psychotic symptoms and beliefs in the pseudoscience have increased. […] We discuss which elements of quarantine coincide with the social marginality theory and its clinical repercussions. | 2020-08-01 |
| 32731913 | In this review, we discuss the basics of the cytokine storm in COVID-19, MSCs, and MSC-derived exosomes and the potential and stem-cell-based ongoing clinical trials for COVID-19. | 2020-08-01 |
| 32732010 | There is limited information regarding clinical characteristics and outcomes of patients with SARS-CoV-2 (COVID-19) disease presenting with ST-segment elevation myocardial infarction (STEMI). | 2020-08-01 |
| 32732015 | The shortage bibliography about nursing care in this pandemic is the reason to develop a useful clinical protocol to attend to the higher number of adult patients who were admitted at Hospitalization Units adapted to patient with COVID-19. […] For that reason, the aim of this document is to provide recommendations to the clinical practice and that way, helping to protocolize the care in adult patients admitted in COVID-19 Hospitalization Units, based in standards of the literature or the most current experience in front of this new pandemic. | 2020-08-01 |
| 32732059 | The severity of the symptoms ranged from mild in 13/23 (65.2 %) of the patients, moderate in 2/23 (8.7 %), and severe in 8/23 (34.8 %). | 2020-08-01 |
| 32732094 | All 256 patients having procedures in the CT room had no post-procedural complications or COVID-19-related symptoms and morbidity on follow-up. | 2020-08-01 |
| 32732168 | A questionnaire was used to collect demographic, occupational and clinical data. […] Frequency of positive tests was more among subjects with minor symptoms compared to completely asymptomatic HCWs (50% vs 16.1%, respectively). […] Presence of positive test results among asymptomatic HCWs illustrates the importance of screening all HCWs irrespective of symptoms. | 2020-08-01 |
| 32732190 | Randomised clinical trials in which people with suspected, probable, or confirmed covid-19 were randomised to drug treatment or to standard care or placebo. | 2020-08-01 |
| 32732237 | Epidemiological and clinical features of these coronavirus disease 2019 (COVID-19) cases were presented for genomic epidemiology studies. | 2020-08-01 |
| 32732245 | Efficacy and safety must be determined in controlled clinical trials. | 2020-08-01 |
| 32732260 | Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has spread in nearly 200 countries in less than 4 months since its first identification; accordingly, the coronavirus disease 2019 (COVID 2019) has affirmed itself as a clinical challenge. […] Given the clinical and epidemiological complexity of COVID-19, patiens with heart failure may require particular care since the viral infection has been identified, considering an adequate re-evaluation of medical therapy and a careful monitoring during ventilation. | 2020-08-01 |
| 32732280 | We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the respiratory tract of aged BALB/c mice. | 2020-08-01 |
| 32732325 | Differences among COVID-19 patients based on two separate clinical endpoints, hospitalisation and adverse outcome, were examined. | 2020-08-01 |
| 32732352 | After rapid market approval in the US, remdesivir is already being used in clinical practice. […] The linked systematic review (published 31 Jul 2020) identified two randomised trials with 1300 participants, showing low certainty evidence that remdesivir may be effective in reducing time to clinical improvement and may decrease mortality in patients with severe covid-19. […] Most patients with severe covid-19 would likely choose treatment with remdesivir given the potential reduction in time to clinical improvement. | 2020-08-01 |
| 32732368 | Endpoints were SARS-CoV-2 positivity (primary) and severe clinical outcomes of COVID-19 (secondary: admission to intensive care unit, administration of invasive ventilation or death). […] Among patients with confirmed COVID-19, the current use of PPIs conferred a 79% greater risk of severe clinical outcomes of COVID-19, while the relationship with the past use of PPIs remained insignificant. […] Current PPI use starting within the previous 30 days was associated with a 90% increased risk of severe clinical outcomes of COVID-19. […] Patients taking PPIs are at increased risk for severe clinical outcomes of COVID-19 but not susceptible to SARS-CoV-2 infection. | 2020-08-01 |
| 32732485 | Updated several times a week with posts by a wide variety of authors, AJN’s blog Off the Charts allows us to provide more timely-and often more personal-perspectives on professional, policy, and clinical issues. | 2020-08-01 |
| 32732512 | Population demographics, comorbidities and clinical outcomes were collected and analyzed. | 2020-08-01 |
| 32732586 | In response to the current outbreak of Coronavirus Disease-2019 (COVID-19), a fast body of literature emerged providing insights into the clinical and radiologic aspects of the novel disease, while the pathologic manifestations on tissue are yet to be sufficiently characterized mainly due to paucity of autopsy and biopsy of these cases. | 2020-08-01 |
| 32732634 | Cross-sectional analysis of the Pharmacokinetic and clinical Observations in PeoPle over fiftY cohort study in the United Kingdom and Ireland. | 2020-08-01 |
| 32732660 | We surveyed five Accreditation Council for Graduate Medical Education-accredited orthopaedic residency programs within cities highly affected by the COVID-19 pandemic about clinical and curricular changes. […] One in three reported being unable to obtain institutionally recommended personal protective equipment during routine clinical work. […] Most have shifted schedules to periods of active clinical duty followed by periods of remote work and self-isolation. | 2020-08-01 |
| 32732694 | Overall, from 24 March to 30 April, 3138 subjects (21.8%) reported COVID-19-like symptoms, and 219 (1.5%) fever above 38.5°C; 217 subjects performed at least one swab. […] There was a strong association between symptoms in the respondent and in cohabitants: 64% of subjects with symptoms reported at least one cohabitant with symptoms, compared to 14% of asymptomatic subjects (OR = 11.4, 95% CI, 10.4-12.6). […] The lower risk of serious symptoms in women, and the strong intra-nucleus of cohabitation contagiousness are an indication that at least part of the symptoms was caused by a new pathogen - SARS-CoV-2. | 2020-08-01 |
| 32732779 | We offer guidelines to modify physical space, clinical services, staffing models, and the importance of steady leadership. […] Pediatric emergency space was converted to adult COVID-19 beds, necessitating the repurposing of nonclinical areas for pediatric patients. […] Efficient clinical pathways were created in collaboration with medical and surgical subspecialists for expedited emergency care of children. […] We transitioned staffing models to meet the changing clinical demands of the emergency department by both reallocation of pediatric emergency medicine providers to telemedicine and by expanding their clinical care to adult patients. […] Modification of physical space, clinical services, staffing models, and the importance of steady leadership enabled us to maintain outstanding clinical care for pediatric patients while maximizing capacity and service for adult COVID-19 patients in the emergency department. | 2020-08-01 |
| 32732883 | The neuropsychiatric sequelae of COVID-19 represent serious clinical challenge that has to be considered for future complex therapies. | 2020-08-01 |
| 32733106 | This approach uses equipment and expertise commonly found in clinical laboratories in developing countries. | 2020-08-01 |
| 32733299 | Prospectively collected and analyzed data included demographics, clinical symptoms, comorbidity, and chest CT imaging features at the first follow up, 1 month after discharge. […] For mental health, the clinical subtypes were significant associated factors (p < 0.05). | 2020-08-01 |
| 32733373 | We assessed demography, clinical variables, Covid-19 severity, laboratory parameters and outcome. […] Patients with CND were older, more disabled, had more vascular risk factors and comorbidities and fewer clinical symptoms of Covid-19. | 2020-08-01 |
| 32733404 | Secondary bacterial infections manifest during or after a viral infection(s) and can lead to negative outcomes and sometimes fatal clinical complications. […] Research and development of clinical interventions is largely focused on the primary pathogen, with research on any secondary infection(s) being neglected. | 2020-08-01 |
| 32733448 | The cell specificity associated with changes in autophagic flux complicates its targeting for amelioration of asthmatic symptoms. | 2020-08-01 |
| 32733480 | Consequently, many viruses (including dengue virus, West Nile virus and Nipah virus) have evolved mechanisms for evasion or dysregulation of the complement system to enhance viral infectivity and even exacerbate disease symptoms. | 2020-08-01 |
| 32733487 | We recommend clinical studies to validate AFO-202 beta glucan in COVID-19 patients to prove its efficacy in overcoming a hyper-inflammation status, thus reducing the mortality, until a definite vaccine is made available. | 2020-08-01 |
| 32733488 | There is an urgency to develop treatments for COVID-19, yet there is limited clinical data on the efficacy of potential drug treatments. | 2020-08-01 |
| 32733490 | The potential risk of vertical transmission is unclear, babies born from COVID-19-positive mothers seems to have no serious clinical symptoms, the possible mechanisms are discussed, which highlights that checking the children’s outcome and more research is warranted. | 2020-08-01 |
| 32733566 | This article summarizes the clinical and surgical experience of the Oral Surgery Unit of the “Mater Domini” Hospital (Magna Graecia University of Catanzaro, Italy) during the COVID-19 pandemic. | 2020-08-01 |
| 32733668 | In addition, we collected data on other relevant clinical elements (i.e. common adverse events, drug-drug interactions with COVID-19 medications, daily doses) and regulatory elements (i.e. therapeutic indications, contra-indications, available formulations). | 2020-08-01 |
| 32733711 | Clinical exam showed desaturation and was suggestive for an acute respiratory infection. | 2020-08-01 |
| 32733724 | The scarcity of data concerning pregnant patients gravely infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) makes their management difficult, as most of the reported cases in the literature present mild pneumonia symptoms. […] A healthy 30-year-old pregnant woman, gravida 6, para 4, at 31 weeks of gestation, presented severe pneumonia symptoms promptly complicated with premature rupture of membranes (PROM). | 2020-08-01 |
| 32733733 | Clinical presentations were similar with fever, abdominal pain, gastrointestinal complaints, and/or rash. […] MIS-C is a recently recognized pediatric illness spectrum in association with SARS-CoV-2 infection, and clinical characterization is essential for understanding disease mechanisms to inform clinical practice. | 2020-08-01 |
| 32733734 | A diagnosis of intra-amniotic infection is typically made based on clinical criteria, including maternal intrapartum fever and one or more of the following: maternal leukocytosis, purulent cervical drainage, or fetal tachycardia. […] The diagnosis can also be made in patients with an isolated fever of 39°C, or greater, without any other clinical risk factors present. […] Coronavirus disease 2019 (COVID-19), caused by the virus SARS-CoV-2, has been noted to have varying signs and symptoms over the course of the disease including fever, cough, fatigue, anorexia, shortness of breath, sputum production, and myalgia. […] In this report, we detail a case of a newborn born to a mother with a clinical diagnosis of intra-amniotic infection with maternal fever and fetal tachycardia, who was then found to be SARS-CoV-2 positive on testing. | 2020-08-01 |
| 32733775 | No validated treatments have been identified for the COVID-19 pandemic virus; several are currently in randomized clinical trials. […] Symptoms range from those of a common cold to acute respiratory distress syndrome (ARDS), to sepsis arising from the flood of inflammatory bacterial and viral pathogens in the blood. […] To address the indisputably urgent need for therapeutics for COVID-19, a specialized interdisciplinary medical panel convened in Shanghai in March 2020 to consider all relevant clinical and experimental evidence on the possible utility of intravenous (IV) ascorbate in the treatment of COVID-19-related ARDS. […] The panel convened multidisciplinary medical experts and reviewed all relevant in vitro, in vivo, clinical studies and randomized controlled trials on IV ascorbate and issued a consensus report on 23 March 2020 noting that substantial differences in serum concentrations of ascorbate are achieved through IV administration in contrast with the oral route. […] We provide an instructive clinical anecdote regarding a single family where one elderly member with cardiac and other major comorbidities developed and survived ARDS-related sepsis following daily treatments that included 15 g of IV ascorbate. | 2020-08-01 |
| 32733837 | Ongoing clinical studies related to possible treatments for COVID-19, potential vaccines, and alternative medication such as natural compounds are also discussed. | 2020-08-01 |
| 32733842 | Nevertheless, several existing drugs are available to relieve the clinical symptoms of COVID-19. | 2020-08-01 |
| 32733907 | Within 72 h, nearly all patients treated with bacteriotherapy showed remission of diarrhea and other symptoms as compared to less than half of the not supplemented group. […] Conclusions: A specific bacterial formulation showed a significant ameliorating impact on the clinical conditions of patients positive for SARS-CoV-2 infection. | 2020-08-01 |
| 32733908 | Symptoms of COVID-19 are not disease-specific. […] Specifically, the case concerns an 82-year-old female, never smoker, who was admitted to our hospital with symptoms of fever and general fatigue that had lasted 7 days. […] Based on high clinical suspicion for ANCA-associated vasculitis, we performed a complete immunologic profile which revealed positive c-ANCA with elevated titers of anti-PR3. | 2020-08-01 |
| 32733921 | Demographic data, clinical characteristics, laboratory tests, treatments, and outcomes were analyzed in this study. | 2020-08-01 |
| 32733978 | We know little about their transmission, behaviors, clinical manifestations, and outcomes. | 2020-08-01 |
| 32733980 | This might help showing which comorbidity might pose the patients at risk of more severe symptoms. […] We searched all relevant databases on April 7th, 2020 using the keywords (“novel coronavirus” OR COVID-19 OR SARS-CoV-2 OR Coronavirus) AND (comorbidities OR clinical characteristics OR epidemiologic*). | 2020-08-01 |
| 32733982 | Analysis was made based on clinical and laboratory data along with the imaging findings from chest HRCT. | 2020-08-01 |
| 32733984 | Here we discuss the issue in terms of clinical severity of COVID-19 pneumonia, priority of orthopedic surgical trauma procedures and standard of care for the treatment of trauma injuries. | 2020-08-01 |
| 32734297 | Follow-up CT should be avoided without clinical decline. […] As COVID-19 is impacting healthcare systems across the globe, we believe in our findings that serial chest CT imaging has limited clinical utility in basically stable COVID-19 patients, will help relieve some of this burden. | 2020-08-01 |
| 32734298 | There is mounting evidence in support of exercise and physical activity as a first-line approach to managing symptoms and potentially altering disease progression in people with Parkinson disease (PD). | 2020-08-01 |
| 32734327 | Clinical parameters and anamnestic data were collected and analyzed. […] No statistical difference was found in complications rate, clinical data and surgical procedures (p > 0.05). | 2020-08-01 |
| 32734353 | We therefore investigated clinical, serological and CSF features of coronavirus disease 2019 (COVID-19) patients with neurological manifestations. […] Increased serum titer of anti-GD1b antibodies was found in three patients and was associated with variable clinical presentations, including cranial neuropathy with meningo-polyradiculitis, brainstem encephalitis and delirium. | 2020-08-01 |
| 32734394 | In the context of cancer patients, COVID-19 has a severe impact, regarding pulmonary infection but also cancer treatments in this fragile and immunocompromised population, and ICU admission for cancer patients in the context of COVID-19 requires ethical and clinical consideration. | 2020-08-01 |
| 32734396 | In COVID-19 patients, the higher prevalence of neurological symptoms and the lack of dyspnea may suggest common underlying pathogenetic mechanisms. […] The aim of this preliminary study is to address whether there is a lack of dyspnea in COVID-19 patients and if there is a relationship between neurological symptoms and the perception of dyspnea. […] A structured interview regarding the occurrence of subjective neurological symptoms was performed and coupled with a questionnaire about the intensity and qualities of dyspnea. […] The prevalence of neurological symptoms, dyspnea descriptors, RR, pH, PaCO2, PaO2, or lactate was similar between groups. […] This study confirms that the prevalence of dyspnea is low in non-severe COVID-19 patients, but contrary to our hypothesis of a relationship between shortness of breath and neurological symptoms, we have not been able to find any evidence of an impairment in dyspnea perception, either in the DYSP or NDYSP group. | 2020-08-01 |
| 32734407 | The diagnosis, grading of severity and clinical management of COVID-19 patients complied to the guideline and clinical protocol issued by the China National Health Commission. | 2020-08-01 |
| 32734438 | Two-thirds (66.5%) had mild to moderate symptoms, the most common being fever (74.0%) and cough (58.3%). | 2020-08-01 |
| 32734464 | To describe the clinical features of COVID-19 in older adults, and relate these to outcomes. […] Cardinal COVID-19 symptoms (fever, dyspnoea, cough) were common but not universal. […] COVID-19 may present without cardinal symptoms as well as implicate a possible role for age-related changes in immunity in mediating the relationship between frailty and mortality. | 2020-08-01 |
| 32734518 | Besides, the possible effective therapeutics’ mechanism and the pharmaceutical agents that had at least one experience as a preclinical or clinical study on COVID-19 were clearly defined. | 2020-08-01 |
| 32734526 | In addition, the diagnosis of ACS may have been difficult due to possible underlying myocarditis or other clinical entities. | 2020-08-01 |
| 32734576 | Common symptoms of deceased included fever (70.6-100%), dyspnea (38.89-85.7%), cough (22.4-78%), and fatigue (22-61.9%). | 2020-08-01 |
| 32734626 | Surgical treatment of T3/T4 melanomas should be prioritized over T1/T2 melanomas except for any melanoma in which large clinical residual lesion is visible. […] Encorafenib and binimetinib should be prioritized for patients requiring BRAF-targeted therapy due to the lower chance of symptoms mimicking COVID-19 infection. | 2020-08-01 |
| 32734670 | Despite continuous reports of clinical trials being launched, no studies have yet systematically summarized and analysed their characteristics. […] We searched the ClinicalTrials.gov database and retrieved all clinical trials on COVID-19 registered up to and including 3 April 2020. […] We identified 306 COVID-19-related clinical trials. […] Five registered clinical trials were on vaccines. | 2020-08-01 |
| 32734689 | Clinical questions were collated, and an evidence report was rapidly generated and disseminated. | 2020-08-01 |
| 32734910 | A set of online questionnaires were used to measure mental problems (i.e., anxiety, insomnia, and depressive symptoms), and help-seeking behavior and treatment for these mental problems. […] 34.0%, adjusted OR=1.88, 95% CI=1.57-2.25), anxiety symptoms (15.7% vs. | 2020-08-01 |
| 32735011 | Comment is made specifically on fitness for work assessments, where the COVID-19 pandemic has posed a range of unique clinical challenges. | 2020-08-01 |
| 32735036 | Several public health interventions and health policy strategies, adequate resources, and focused clinical quality improvement initiatives can help calm the storm. | 2020-08-01 |
| 32735062 | Source of infection was likely clinical activity in 175 (54%) cases. […] The etiology of reported cases within the otolaryngology community appear to stem equally from clinical activity and community spread. | 2020-08-01 |
| 32735163 | Here, we report an in-flight transmission cluster of COVID-19 and describe the clinical characteristics of these patients. […] Clinical information was retrospectively collected. […] There is potential for COVID-19 transmission in aeroplanes, but the symptoms were mild in our patients. | 2020-08-01 |
| 32735170 | Despite some similarities in clinical features between the two entities, such as hypoxemia, radiographic opacities, and altered lung compliance, the pathophysiological mechanisms of HAPE and lung injury due to COVID-19 are fundamentally different, and the entities cannot be viewed as equivalent. | 2020-08-01 |
| 32735339 | The model assumed a symptomatic case fatality risk of 0.05% and a 30% probability that infection would eventually lead to observable COVID-19-defining symptoms in the cohort. | 2020-08-01 |
| 32735448 | We analysed consecutive COVID-19 patients (RT-PCR confirmed) undergoing CTPA in March 2020 for PTE clinical suspicion. […] Clinical data were retrieved. | 2020-08-01 |
| 32735457 | The analysis of all available current medical, laboratory and imaging data on COVID-19 confirms that symptoms and diagnostic tests can not be explained by impaired pulmonary ventilation. | 2020-08-01 |
| 32735546 | The aims of this study are to identify off-label drugs that may have benefits for the coronavirus disease pandemic, present a novel ranking algorithm called CovidX to recommend existing drugs for potential repurposing, and validate the literature-based outcome with drug knowledge available in clinical trials. […] The algorithm validates the ranking and awards those drugs that are currently being investigated in open clinical trials. […] The rationale behind the open clinical trial is to provide a validating mechanism of the PubMed results. […] From the analyzed biomedical literature, the algorithm identified 30 possible drug candidates for repurposing, ranked them accordingly, and validated the ranking outcomes against evidence from clinical trials. | 2020-08-01 |
| 32735549 | We present an ANN that can provide a patient-specific, point-of-admission mortality risk prediction to inform clinical management decisions at the earliest opportunity. […] The ANN analyzes a set of patient features including demographics, comorbidities, smoking history, and presenting symptoms and predicts patient-specific mortality risk during the current hospital admission. | 2020-08-01 |
| 32735690 | Further clinical trials should be carried out to test the efficacy of this device to reduce aerosol dispersion and the consequent vector of contamination, as well as the ergonomic impacts related to its use. | 2020-08-01 |
| 32735699 | (…) Small increments in clinical improvement will still be possible in the future, but for the most part, the potential for major advancement using these techniques has been exhausted’ (Frank Hanley, MD; Stanford). […] To develop the skills and expertise in both clinical congenital cardiology and basic research, the training of fellows must be focused and integrated. | 2020-08-01 |
| 32735706 | This study aimed to observe the clinical characteristics of patients with coronavirus disease 2019 (COVID-19) with overweight and obesity. | 2020-08-01 |
| 32735768 | However, the efficacy of these treatments still needs well-planned clinical trials. | 2020-08-01 |
| 32735799 | Due to their pleiotropic activities and lack of systemic toxicity, flavonoids and their derivative may represent target compounds to be tested in future clinical trials to enrich the drug arsenal against coronavirus infections. | 2020-08-01 |
| 32735849 | We also developed a focus-reduction neutralization test with a clinical isolate of SARS-CoV-2 at biosafety level 3. | 2020-08-01 |
| 32735885 | This study aimed to make a comparison between the clinical laboratory-related factors, complete blood count (CBC) indices, cytokines, and lymphocyte subsets in order to distinguish severe coronavirus disease 2019 (COVID-19) cases from the non-severe ones. | 2020-08-01 |
| 32735889 | Coronavirus disease 2019 has markedly varied clinical presentations, with most patients being asymptomatic or having mild symptoms. | 2020-08-01 |
| 32735893 | Care home staff were tested for SARS-COV-2 infection by RT-PCR and asked to report any symptoms, their contact with residents and if they worked in different care homes. | 2020-08-01 |
| 32735965 | Finite clinical data and understanding of COVID-19 immunopathology has led to limited, opinion-based recommendations for the management of patients with immune-mediated inflammatory disease (IMID) receiving immunosuppressive (IS) therapeutics. | 2020-08-01 |
| 32736007 | There are currently limited data on the epidemiology, clinical manifestations, and optimal management of Coronavirus Disease 2019 (COVID-19) in hematopoietic cell transplantation and cellular therapy recipients. […] Given the experience with other respiratory viruses, we anticipate that patients may develop severe clinical disease and thus provide the following general principles for cancer centers across the nation. | 2020-08-01 |
| 32736186 | The current study (1) described prevalence rates of maternal depressive and anxiety symptoms from an online convenience sample during the COVID-19 pandemic, (2) identified risk and protective factors for elevated symptoms, and (3) described current mental health service use and barriers. | 2020-08-01 |
| 32736195 | Although close contacts had physical symptoms and psychological issues, they adopted positive coping strategies, which indicated that they were vulnerable but strong. | 2020-08-01 |
| 32736197 | To clarify the epidemiological, clinical, and therapeutic features of patients with severe COVID-19. […] The epidemiological, demographic, clinical, laboratory, treatment, and outcome data were collected. | 2020-08-01 |
| 32736237 | The aim of the present study was to identify the clinical efficacy of glucocorticoid therapy on the treatment of patients with Coronavirus Disease 2019 (COVID-19) pneumonia. […] Clinical and laboratory parameters were collected from 308 patients with COVID-19 pneumonia from the fever clinic of Wuhan Pulmonary Hospital (Wuhan City, Hubei Province, China) between January 14, 2020 and February 9, 2020, of which 216 patients received low-dose (equivalent of methylprednisolone 0.75-1.5 mg/kg/d) glucocorticoid treatment. […] Compared with the non-glucocorticoid therapy group, glucocorticoid therapy did not significantly influence the clinical course of COVID-19 pneumonia, including imaging progress and the time duration for negative transformation of nucleic acid. | 2020-08-01 |
| 32736407 | · Majority of COVID-19 positive neonates showed mild clinical signs and symptoms with no mortality.. | 2020-08-01 |
| 32736419 | COVID-19clinical cases are considered as the principal source of infection, however, asymptomatic cases may also play a role in the transmission. | 2020-08-01 |
| 32736485 | To evaluate the impact of COVID-19 on symptoms, clinical characteristics, and outcomes for patients referred to a hospital-based palliative care service in a district general hospital in London, UK. […] Breathlessness, drowsiness, agitation, and fever are the most prevalent symptoms during COVID-19 compared to pain and drowsiness pre-COVID-19. | 2020-08-02 |
| 32736592 | Randomised, parallel arm, open-label, adaptive platform Phase 2/3 trial of potential disease modifying therapies in patients with late stage 1/stage 2 COVID-19-related disease, with a diagnosis based either on a positive assay or high suspicion of COVID-19 infection by clinical, laboratory and radiological assessment. […] Patients aged 18 and over, with a clinical picture strongly suggestive of COVID-19-related disease (with/without a positive COVID-19 test) AND a risk count (as defined below) >3 OR ≥3 if risk count includes “Radiographic severity score >3”. […] If this biomarker futility analysis is not conclusive, then a second futility analysis based on clinical endpoints will be performed after approximately 125 patients have been recruited per arm. […] Provisionally, further analyses of clinical endpoints will be performed after 229 patients per active arm and later 469 patients per arm have been recruited. […] Registered on EU Clinical Trials Register EudraCT Number: 2020-002229-27 registered: 9 June 2020. | 2020-08-02 |
| 32736596 | The study will include hospitalised adult patients (≥18 years) with confirmed SARS-CoV-2 infection, the virus that causes COVID-19, that clinically meet Grades 3 (hospitalised - mild disease, no oxygen therapy), Grades 4 (hospitalised, oxygen by mask or nasal prongs) and 5 (hospitalised, non-invasive ventilation or high flow oxygen) of the WHO Working Group on the Clinical Characteristics of COVID-19 9-point category ordinal scale. […] Time to sustained clinical improvement of at least 2 points (from randomisation) on the WHO 9-point category ordinal scale, live discharge from the hospital, or considered fit for discharge (a score of 0, 1, or 2 on the ordinal scale), whichever comes first, by Day 29 (this will also define the “responder” for the response rate analyses). | 2020-08-02 |
| 32736597 | The main objective of the present study is to evaluate the efficacy of hydroxychloroquine for (I) the prevention of COVID-19 or related symptoms in SARS-CoV-2-exposed subjects, such as as household members/contacts of COVID-19 patients and (II) the treatment of early-phase asymptomatic or paucisymptomatic COVID-19 patients. […] Paucisymptomatic patients are defined as patients with a low number of mild symptoms. […] The study protocol has been reported in accordance with Standard Protocol Items: Recommendations for Clinical Interventional Trials (SPIRIT) guidelines (Additional file 2). | 2020-08-02 |
| 32736821 | Sociodemographic, clinical, functional, mental, analytical, radiological, therapeutic and healthcare variables were collected. […] The main symptoms were fever (60,3%), dyspnea (53.4%) and deterioration of functional condition (50%). | 2020-08-02 |
| 32736887 | Dysphagia treatment includes a broad range of clinical assessments and examinations, dysphagia rehabilitation, oral care, nursing care, and surgical treatments. […] This statement is arranged into separate sections providing information and advice in consideration of the COVID-19 outbreak, including “terminology”, “clinical swallowing assessment and examination”, “swallowing therapy”, “oral care”, “surgical procedure for dysphagia”, “tracheotomy care”, and “nursing care”. […] The current set of statements on dysphagia management in the COVID-19 outbreak is not an evidence-based clinical practice guideline, but a guide for all healthcare workers involved in the treatment of dysphagia during the COVID-19 epidemic to prevent SARS-CoV-2 infection. | 2020-08-02 |
| 32737005 | We described scaling our telemedicine urgent care capacity, described patient clinical characteristics, assessed for emergency department (ED) referrals, and analyzed postvisit surveys. […] The most frequent diagnoses were COVID-19 related or upper respiratory symptoms. | 2020-08-02 |
| 32737069 | This study aimed to systematically investigate the consistency of recommendations from the available clinical practice guidelines (CPGs) to those of the WHO on the management of critically ill COVID-19 patients. […] These inconsistencies should best be addressed by consensus among the relevant bodies to avoid confusion in clinical practice while awaiting clinical trials to inform us of the best practice. | 2020-08-02 |
| 32737082 | This study highlights the clinical utility of demographic factors for individualized risk-stratification of patients and support further research into emerging anti-Covid-19 therapeutics in SARS-Cov-2 infected cancer patients. | 2020-08-02 |
| 32737100 | We will also search for clinical trial registries, such as ClinicalTrials.gov, for the ongoing clinical trials. […] All randomised clinical trials investigating the safety and efficacy of favipiravir compared with other control groups for the treatment of patients with confirmed infection with SARS-CoV-2 will be included. […] The desired secondary outcome will consist of a decreased rate of symptoms, proportion of intensive care unit (ICU) transfers, length of the hospital stay, ICU treatments, the quality of life and additional adverse events. | 2020-08-02 |
| 32737292 | The socio-demographic and clinical characteristics, psychosomatic conditions, interpersonal relationships and social support, COVID-19 infection-related psychological stress, and mental health status were measured. | 2020-08-02 |
| 32737472 | We report and contextualize epidemiological, demographic and clinical findings for COVID-19 cases during the first 3 months of the epidemic. | 2020-08-02 |
| 32737507 | Considering the similarities in pathology and clinical presentation of SARS-CoV and COVID-19, it is likely that COVID-19 patients will present with similar impairments to physical function. | 2020-08-02 |
| 32737627 | Clinical features of patients with COVID-19 have been described. […] Clinical data including characteristics, laboratory and imaging information as well as treatments were extracted from electronic medical records and compared. | 2020-08-02 |
| 32737746 | We summarize the clinical signs and laboratory tests needed to confirm candidiasis, aspergillosis, or pneumocystosis in our COVID-19 patients. | 2020-08-02 |
| 32737747 | We suggest it is prudent to assess the risk factors, the types of invasive mycosis, the strengths and limitations of diagnostic methods, clinical settings, and the need for standard or individualized treatment in COVID-19 patients. […] We provide a clinical flow diagram to assist the clinicians and laboratory experts in the management of aspergillosis, candidiasis, mucormycosis, or cryptococcosis as co-morbidities in COVID-19 patients. | 2020-08-02 |
| 32737799 | As a result, treatment with lopinavir/ritonavir was initiated, and patient symptoms and signs improved significantly during the course of hospitalization. | 2020-08-02 |
| 32737838 | The Covid-19 pandemic led to a complete renewal of clinical activities of Italian hospitals. […] During the lockdown, all hospitals in Italy had to suspend non-urgent clinical activities. […] Body temperature <37.5 degrees C and no Covid-19 symptoms were necessary to enter the unit. […] No Covid-19 infection symptoms were reported. | 2020-08-02 |
| 32737861 | This review covers basic CoV biology pertinent to CNS disease; the spectrum of clinical abnormalities encountered in infants, children, and adults; and the evidence for CoV infection of human brain, with reference to pertinent animal models of neuropathogenesis. | 2020-08-02 |
| 32738040 | Adrenal insufficiency is life threatening; therefore, we suggest that early adrenal axis testing for COVID-19 patients with clinical suspicion of adrenal insufficiency should be carried out. | 2020-08-02 |
| 32738143 | Clinical and demographic data on the first 270 SARS-CoV-2 infected cases and the timing and nature of Government control measures, including numbers of tests and quarantined individuals, were analysed. | 2020-08-02 |
| 32738144 | Data from the Understanding America Study are used to describe group differences in reports of psychological distress and somatic symptoms. | 2020-08-02 |
| 32738184 | While the virus uses angiotensin-converting enzyme 2 (ACE2) as the primary entry receptor, the recent experimental and clinical findings suggest that some tumor markers, including CD147 (basigin), can provide an additional entry for SARS-CoV-2 infection through binding to the viral spike (S) protein. | 2020-08-02 |
| 32738287 | We investigated the psychopathological impact of COVID-19 in survivors, also considering the effect of clinical and inflammatory predictors. […] We screened for psychiatric symptoms 402 adults surviving COVID-19 (265 male, mean age 58), at one month follow-up after hospital treatment. […] A clinical interview and a battery of self-report questionnaires were used to investigate post-traumatic stress disorder (PTSD), depression, anxiety, insomnia, and obsessive-compulsive (OC) symptomatology. […] We collected sociodemographic information, clinical data, baseline inflammatory markers and follow-up oxygen saturation levels. […] A significant proportion of patients self-rated in the psychopathological range: 28% for PTSD, 31% for depression, 42% for anxiety, 20% for OC symptoms, and 40% for insomnia. […] Overall, 56% scored in the pathological range in at least one clinical dimension. | 2020-08-02 |
| 32738306 | Clinical trials have reported improved outcomes resulting from an effective reduction or absence of viral load when patients were treated with chloroquine (CQ) or hydroxychloroquine (HCQ). | 2020-08-02 |
| 32738407 | The objective of this study was to investigate the clinical usefulness of d-dimer in excluding a diagnosis of deep vein thrombosis (DVT) in patients with coronavirus disease (COVID-19) infection, potentially limiting the need for venous duplex ultrasound examination. | 2020-08-02 |
| 32738464 | The goal of this study was to assess chest computed tomography (CT) diagnostic accuracy in clinical practice using RT-PCR as standard of reference. […] Twenty-five/66 (37.6 %) patients with positive CT and negative RT-PCR results and 12/245 (4.9 %) patients with both negative tests were nevertheless judged as positive cases by the clinicians based on clinical and epidemiological criteria and consequently treated. […] In our experience, in a context of high pre-test probability, CT scan shows good sensitivity and a consistently higher specificity for the diagnosis of COVID-19 pneumonia than what reported by previous studies, especially when clinical and epidemiological features are taken into account. | 2020-08-02 |
| 32738497 | With the increasing number of COVID-19 cases in the United States, more data is being reported on transmission, symptomatology, clinical course, and treatment of the virus. | 2020-08-02 |
| 32738510 | Therefore, it makes sense to consider the use of ω-3 PUFAs for clinical management of COVID-19 patients. ω-3 PUFAs may be given by oral, enteral, or parenteral routes; however, the parenteral route favors faster incorporation into plasma phospholipids, blood cells, and tissues. | 2020-08-02 |
| 32738585 | It is important for neurosurgeons to realize that patients can present with these findings without primary pulmonary symptoms, and that severe pulmonary symptoms, elevated INR, and spontaneous hemorrhagic presentations is associated with increased risk for mortality. | 2020-08-02 |
| 32738839 | The present retrospective observational study, on 35 symptomatic and 35 asymptomatic patients, was carried out in SMS Medical College and Hospital, Jaipur comparatively assessing epidemiological history, clinical features and laboratory investigations. […] Lymphopenia is an effective and reliable indicator of onset of symptoms and severity of disease in COVID-19 patients. […] RDW was found to be higher in COVID 19 patients in comparison to normal patients, however it had no significant relationship with appearance of symptoms or severity of the disease. | 2020-08-03 |
| 32738843 | To assess clinical outcomes in consecutively hospitalized patients with mild covid-19 in India we performed a study. […] Demographic, clinical, investigations details and outcomes were recorded. […] Symptoms were in less than 10% and comorbidities were in 4-8%. | 2020-08-03 |
| 32738845 | Thorough clinical examination and laboratory investigations including Complete Blood Count, Renal function Tests, Liver Function Tests, Chest X-ray, ECG, etc. were done. | 2020-08-03 |
| 32738881 | The most prevalent topics of research in COVID-19 include “clinical features studies”, “pathological findings and therapeutic design”, “care facilities preparation and infection control”, and “maternal, perinatal and neonatal outcomes”. […] The findings reported here shed new light on the major progress in the near future for hot topics on COVID-19 research including clinical features studies, pathological findings and therapeutic design, care facilities preparation and infection control, and maternal, perinatal and neonatal outcomes. | 2020-08-03 |
| 32739134 | The results were discussed with a Primary Care physicians clinical group and the results were synthesized using GRADE methodology. […] Although the conclusions of the systematic review generate a low confidence in the results, and the clinical variables that show benefit are intermediate variables, the side effects are acceptable and could be minimized with the use of QT lengthening risk tools, so it is could make a weak recommendation in favor of the use of chloroquine/hydroxychloroquine in patients with mild-moderate stage COVID-19. | 2020-08-03 |
| 32739140 | Secondary outcomes were the rate of coronavirus disease 2019 infections, new onset of pulmonary symptoms after hospitalization, and requirement for admission to the intensive care unit. | 2020-08-03 |
| 32739342 | This review outlines the current evidence regarding proposed treatments- experimental or repurposed, for COVID-19, and gives an insight into the clinical trial landscape for drugs as well as vaccines. | 2020-08-03 |
| 32739397 | Preliminary reports suggest that the disease may present in diverse ways, including with neurological symptoms, but few published reports in the literature describe seizures in patients with COVID-19. […] The objective of the study was to characterize the risk factors, clinical features, and outcomes of seizures in patients with COVID-19. […] Three patients had no preceding symptoms of COVID-19 prior to presentation (57%), and in all cases, seizures were the symptom that prompted presentation to the emergency department, regardless of prior symptoms of COVID-19. […] In endemic areas with community spread of COVID-19, clinicians should be vigilant for the infection in patients who present with seizures, which may precede respiratory symptoms or prompt presentation to medical care. | 2020-08-03 |
| 32739404 | CVC is currently under clinical trials in the patients for treatment of nonalcoholic steatohepatitis, in which immune cell activation and dysregulation of proinflammatory cytokines play an important role in its pathogenesis. | 2020-08-03 |
| 32739443 | Within the realm of surgical training, the resultant reduction in clinical exposure and case volume jeopardizes the quality of surgical training. […] Thus, our general surgery residency program proceeded to develop a tailored approach to training that mitigates impact on resident surgical education and optimizes clinical exposure without compromising safety. […] With the decrease in operative volume and clinical duties, we shifted our educational focus to an intensive didactic schedule using a teleconferencing platform and targeted areas of weakness on prior in-service exams. | 2020-08-03 |
| 32739606 | Based on data from previous reports, it has been noticed that contrary to prior pandemics such as SARS, MERS and H1N1 and although pregnancy is usually considered as a condition of high susceptibility to viral infections, new SARS-CoV2 infection seems to have a more benign clinical course when affecting pregnant women. | 2020-08-03 |
| 32739645 | Taking the physiological advantage of pregnant women, potential clinical trials are proposed. | 2020-08-03 |
| 32739797 | Further, we discuss the reasons for the observed false-negative and false-positive RNA and antibody detection results in practical clinical applications. | 2020-08-03 |
| 32739959 | Here, biomarkers of coagulation (such as D-dimer, fibrinogen, platelet count), inflammation (such as interleukin-6) and immunity (such as lymphocyte count) as well as clinical scoring systems (such as SOFA, ISTH DIC and SIC score) can be helpful in predicting clinical course, need for hospital resources (such as ICU beds, intubation and ventilator therapy, and ECMO) and patient’s outcome in patients with COVID-19. […] Whether viscoelastic testing can provide additional value in predicting clinical course, need for hospital resources and patient’s outcome or in guiding anticoagulation in COVID-19 associated coagulopathy is still incompletely understood and currently under investigation (e.g., in the ROHOCO study). | 2020-08-03 |
| 32740063 | Like COVID-19, the rapid emergence of Ebola required new clinical and surgical approaches to understand its associated spectrum of ophthalmic complications and the potential for Ebola viral persistence within the eye and in tear film. […] Vision health systems preparedness measures developed during recent EVD outbreaks and the current pandemic provide models for ophthalmic clinical practice, research, and education, as we continue to address COVID-19 and future emerging infectious disease threats. | 2020-08-03 |
| 32740064 | Several tissue transplantation organizations have guidelines in place regarding the screening of donors and tissue procurement procedures, including clinical and/or PCR screening of donors. | 2020-08-03 |
| 32740069 | Transformative new models incorporating digital technology are needed to address these gaps in clinical care. | 2020-08-03 |
| 32740251 | Regarding health care workers safety, four health care workers presented with potential COVID-19 related symptoms and none was positive. | 2020-08-03 |
| 32740371 | We conducted a retrospective study to summarize the clinical practices of nonsevere patients with COVID-19 receiving the standard care, LPV/r or chloroquine in Beijing Ditan Hospital from January 20 to March 26, 2020. […] Antiviral therapy using LPV/r or chloroquine seemed not to improve the prognosis or shorten the clinical course of COVID-19. | 2020-08-03 |
| 32740406 | In this retrospective study, we analyzed data using electronic medical records from all hospitalized Covid-19 African-American patients, who either died in the hospital or survived to discharge between 2 March and 22 May 2020. | 2020-08-03 |
| 32740456 | In this article, we describe a case of vertical transmission of severe acute respiratory syndrome coronavirus 2 in a newborn with respiratory and gastrointestinal symptoms. | 2020-08-03 |
| 32740498 | None of these patients nor their parents or accompanying person was found to be COVID-19-positive; 2 pediatric intensivists were found to be COVID-19-positive, and needed hospitalization without mechanical ventilation; 13 nurses had positive COVID swabs (4 with symptoms), and were managed and isolated at home. | 2020-08-03 |
| 32740530 | In April 2020, a newly recognized pediatric disorder associated with COVID-19 characterized by significant inflammation with symptoms resembling Kawasaki disease was described by medical teams in the United States, the United Kingdom, and Italy. | 2020-08-03 |
| 32740766 | An increasing body of evidence suggests that patients with the coronavirus disease (COVID-19) might have a heterogeneous spectrum of neurological symptoms METHODS: A systematic search of two databases was performed for studies published up to May 29th, 2020. […] Symptoms related to muscular injury ranged between 15 and 30%. | 2020-08-03 |
| 32740801 | Preliminary clinical evidence suggests these drugs may have an effect on the treatment of COVID-19. […] Herein, we review the pharmacokinetics characteristics and antiviral effects of these drugs, in addition to their side effects and clinical evidence of their use for the COVID-19 treatment. | 2020-08-03 |
| 32740817 | This study proposes a clinical computer-aided diagnosis (CAD) system using CT features to automatically discriminate COVID-19 from non-COVID-19 pneumonia patients. | 2020-08-03 |
| 32740890 | Clinical reports show that the most commons symptoms are fever, dry cough, and shortness of breath, along with several other symptoms. […] Mesenchymal stem cell (MSC) therapy has been shown to alleviate pneumonia and acute respiratory syndrome (ARDS) symptoms, through their immunomodulatory activities in COVID-19 patients. […] Although more research studies and clinical trial results are needed to elucidate the exact mechanism by which MSCs provide relief to COVID-19 infected patients. […] Results from clinical trials are encouraging as patients treated with MSCs, regain lung functions and have restored levels of cytokines and trophic factors underscoring the fact that stem cell therapy can be, at least, a complementary therapy to alleviate sufferings in COVID-19 patients. | 2020-08-03 |
| 32740969 | The SARS-CoV-2 pandemic has drastically altered all facets of clinical care and research. […] Clinical research in hepatology has had a rich tradition in several domains, including the discovery and therapeutic development for diseases such as hepatitis B and C, and studying the natural history of many forms of chronic liver disease. […] Instantaneously, however, all non-essential research activities were halted when the pandemic started, forcing those involved in clinical research to re-think their research strategy, including a shift to COVID-19 research while endeavoring to maintain their pre-existing agenda. […] The implementation of telemedicine has been dramatically accelerated and will serve as a backbone for the future of clinical research. […] As we move forward, innovation in clinical trial design will be essential for conducting optimized clinical research. | 2020-08-03 |
| 32740984 | We also assessed clinical variables associated with change in glycaemic control. | 2020-08-03 |
| 32741085 | We systematically searched MedLine (PubMed), Embase, Health Management Information Consortium (HMIC), Medrxiv, the Cochrane Library, the Cochrane COVID-19 Study Register, NIHR Dissemination centre, Clinical Evidence, National Health Service Evidence and the National Institute of Clinical Excellence to identify the current published evidence which associates coronaviridae or similar RNA viruses with anosmia. […] Olfactory dysfunction has been shown to be the strongest predictor of COVID-19 positivity when compared to other symptoms in logistic regression analysis. […] We have demonstrated that OD is comparatively more predictive for COVID-19 positivity compared to other associated symptoms. | 2020-08-03 |
| 32741139 | Included studies described one or more relevant clinical outcomes in five or more people who were infected with SARS-CoV-2 and were treated with antirheumatic disease therapy between 01/01/2019 and 05/29/2020. | 2020-08-03 |
| 32741205 | The prevalence of anxiety symptoms and depressive symptoms was 33.7% and 57.9%, respectively, and 59.7% reported mild to extremely severe levels of stress. | 2020-08-04 |
| 32741218 | Through this narrative review, we provide an evidence-based overview of idiopathic and secondary chilblains, distinguishing features of COVID-19 chilblains, and a systematic clinical approach to history, examination, investigations, and treatment. | 2020-08-04 |
| 32741322 | DB02498 (Carba-nicotinamide-adenine-dinucleotide) is an approved drug which has been used since the late 1960s in intravenous form to significantly lessen withdrawal symptoms from a variety of drugs and alcohol addicts and it has the best MM-PBSA binding free energy of-12.83 ± 0.52 kcal/mol. | 2020-08-04 |
| 32741438 | Chemosensory loss is a common symptom of coronavirus disease 2019 (COVID-19) and has been associated with a milder clinical course in younger patients. […] Subjective chemosensory function, symptoms of COVID-19, COVID-19 tests results, demographics and medical history were collected through a questionnaire. […] For participants with olfactory loss, only 44% had fully recovered, whereas 28% had not yet experienced any improvement of symptoms. | 2020-08-04 |
| 32741545 | This holds true for non-dentist health care workers who often in the setting of emergency departments and urgent care centers are tasked with addressing oral symptoms including abscesses, damaged teeth, jaw injuries and other dental urgencies. | 2020-08-04 |
| 32741663 | No patient of the 129 included reported suspected symptoms; 3 isolated themselves in auto-quarantine for flu-like symptoms. | 2020-08-04 |
| 32741691 | Many residency programs have organized rotating skeleton crews to perform clinical duties while a portion of residents work from home. […] With these interruptions in urologic education, many questions remain about how residents will proceed with their clinical and didactic training. | 2020-08-04 |
| 32741731 | To eradicate these risks, it is necessary to determine the COVID-19 zoonotic source of transmission to humans and clinical manifestations in infected individuals. | 2020-08-04 |
| 32741802 | We analyzed the clinical and CT characteristics of the patients. […] The most widespread presenting symptoms were fever (32/33, 97.0%) and cough (17/33, 51.5%), which were often accompanied by decreased lymphocyte count (15/33, 45.5%) and increased C-reactive protein levels (18/33, 54.6%). […] In patients recovering from moderate COVID-19 pneumonia, four stages (stages 1-4) of evolution were identified on chest CT with average CT scores of 3.4±2.3, 6.0±4.4, 5.6±3.8, and 4.9±3.2, respectively, from the onset of symptoms. […] For most patients, the peak of average total CT score increased for approximately 8 days after the onset of symptoms, after which it decreased gradually. | 2020-08-04 |
| 32741930 | Current clinical examinations for treatment and discharge standard are limited to respiratory samples. | 2020-08-04 |
| 32741931 | To analyze clinical characteristics and potential predictors of disease severity in patients with COVID-19. […] Clinical data from 64 patients with COVID-19 were retrospectively analyzed. | 2020-08-04 |
| 32742146 | The randomized clinical trial (RCT) has long been recognized as the ‘gold standard’ for developing evidence for clinical treatments and vaccines; however, the successful implementation and translation of these findings is predicated upon external validity. | 2020-08-04 |
| 32742564 | Cell therapy is a promising therapeutic strategy for refractory and unmanageable pulmonary illnesses, as proved by accumulating preclinical studies. […] Mesenchymal stromal cells, endothelial progenitor cells, peripheral blood stem cells, and lung progenitor cells have been applied to clinical trials. […] In this review, we systematically summarize the global trends for the cell therapy of common airway and lung diseases registered for clinical trials. […] The future directions for both new clinical trials and preclinical studies are discussed. | 2020-08-04 |
| 32742639 | Heat is a cheap, convenient and widely accessible therapeutic modality and while no clinical protocols exist for using heat to treat COVID-19, protocols that draw from traditional practices and consider contraindications, adverse effects and infection control measures could be developed and implemented rapidly and inexpensively on a wide scale. | 2020-08-05 |
| 32742648 | This retrospective study is the first from Jordan to report the epidemiologic, clinical, laboratory, and radiologic characteristics of COVID-19 infected patients. […] The clinical features, radiological, and laboratory findings were reviewed. […] The most common presenting symptoms were nasal congestion, sore throat and dry cough. | 2020-08-04 |
| 32742654 | Demographic, clinical and laboratory data from hospitalised COVID-19 patients from a single centre with two consecutive negative respiratory reverse transcription-polymerase chain reaction (RT-PCR) results were extracted from electronic medical records. […] Kaplan-Meier survival curve analysis was used to assess the effect of clinical characteristics on the duration and pattern of shedding. | 2020-08-04 |
| 32742855 | This observation begs the question: “Why does pregnancy not increase the risk for acquiring SARS-CoV-2 infection, nor does it worsen the clinical course of COVID-19 compared with non-pregnant individuals?” | 2020-08-04 |
| 32742867 | COVID-19 leads to a plethora of clinical syndromes, most commonly affecting the pulmonary system but also the cardiovascular, hematologic, and gastrointestinal systems. […] In this report, we have discussed three cases with a COVID-19 infection, whose clinical course was complicated by the presence of pulmonary embolism (PE) without evident risk factors for VTE. | 2020-08-04 |
| 32742920 | While the world struggles under the coronavirus disease 2019 (COVID-19) pandemic, a variety of antiviral agents and symptomatic treatments are being administered to patients and urgent clinical trials are underway. […] Among various herbal medicines, Soshihotang (SSHT, Xiao Chai Hu Tang in Chinese) has been prescribed to treat various viral diseases and is used in combination with other herbal medicines depending on the patient’s symptoms. […] For conducting the present review, we searched electronic databases focusing on the antiviral effect of SSHT in experimental and clinical study until April 2020. […] In a number of recent clinical studies, treatment with SSHT improved the infection status of the respiratory and hepatobiliary systems, and experimental studies demonstrated the antiviral effect of SSHT and its components. | 2020-08-04 |
| 32742969 | All patients in this cohort (N: 33) were positive for SARS-CoV-2 by polymerase chain reaction (PCR) and they attended the hospital with variable presenting symptoms those ranged from cough and fever to respiratory distress and pneumonia. […] The rest 30 patients were discharged from the medical college hospital after being negative for SARS-CoV-2 in two subsequent assessments and improvement of their COVID-related symptoms. | 2020-08-04 |
| 32742970 | All patients in this cohort (N: 32) were positive for SARS-CoV-2 by polymerase chain reaction (PCR) with variable presenting symptoms. […] All patients were discharged with improvement of subjective symptoms and SARS-CoV-2 negativity. | 2020-08-04 |
| 32742978 | COVID-19 is characterized by acute respiratory disease, with 80% of patients presenting mild like flu-like symptoms; however, 20% of patients may have a severe or critical clinical presentation, which likely causes multiple organ injuries (e.g., kidney, heart, blood, and nervous system). […] In this review, we summarize the clinical characteristics of COVID-19 induced AKI by focusing on its epidemiology, pathogenesis, clinical diagnosis, and treatment. | 2020-08-04 |
| 32743014 | Clinical manifestation and neonatal outcomes of pregnant women with coronavirus disease 2019 (COVID-19) were unclear in Wuhan, China. […] We retrospectively analyzed clinical characteristics of pregnant and nonpregnant women with COVID-19 aged from 20 to 40, admitted between January 15 and March 15, 2020 at Union Hospital, Wuhan, and symptoms of pregnant women with COVID-19 and compared the clinical characteristics and symptoms to historic data previously reported for H1N1. […] Pregnant and nonpregnant patients show differences in symptoms such as fever, expectoration, and fatigue and on laboratory tests such as neurophils, fibrinogen, D-dimer, and erythrocyte sedimentation rate. […] Pregnant patients with COVID-19 tend to have more milder symptoms than those with H1N1. […] Clinical characteristics of pregnant patients with COVID-19 are less serious than nonpregnant. | 2020-08-04 |
| 32743022 | Indeed, through the wide innervation of the organism by the vagus nerve, especially the lungs and gastrointestinal tract, VNS appears as a serious candidate for a few side effect treatment that could dampen or prevent the cytokine storm observed in COVID-19 patients with severe symptoms. | 2020-08-04 |
| 32743642 | These symptoms had high specificity (93% each, 96% for either) for a positive SARS-CoV-2 test. | 2020-08-04 |
| 32743705 | The medical records of the patients were reviewed for gathering information about demographic data, clinical follow-up, and treatments. […] None, including the confirmed case, had any severe symptoms. | 2020-08-04 |
| 32743723 | On day 2, the neonate developed clinical features of COVID in the form of fever, poor feeding, and hyperbilirubenemia along with elevated inflammatory markers. | 2020-08-04 |
| 32743793 | Patients with co-morbidities such as hypertension, cardiovascular disease, and diabetes mellitus (DM) seem to be more prone to severe symptoms and appear to have a higher mortality rate. | 2020-08-04 |
| 32743795 | This paper addresses the need for a swift transition from in-person clinical supervision to telesupervision during the time of the COVID-19 global pandemic. […] Five specific areas will be discussed in the effort to enhance the quality of clinical supervision provided to couple and family therapists in training at this time including the following: (1) COVID-19 and the structural changes and technological adaptation of supervision; (2) culturally and contextually sensitive guidelines for clinical supervision during COVID-19; (3) the supervisee’s competence and the clinical supervisory process; (4) the new set of boundaries and the supervisory role; (5) and the supervisory alliance and supervisees’ vulnerabilities in the face of COVID-19. | 2020-08-04 |
| 32743882 | A telephone survey of heart (n = 69) and lung (n = 41) transplant patients and a group of controls (n = 41) was conducted concerning personal hygiene before and after the outbreak; the impact on subjective expectations regarding graft outcome; symptoms possibly associated with SARS-CoV-2 infection; and diagnosis of COVID-19. […] Nine LTX and five Heart transplant (HTX) patients experienced symptoms that could have been associated with SARS-CoV-2 infection, but none of them underwent a nasopharyngeal swab. | 2020-08-04 |
| 32743901 | We report the complex clinical course of SARS-CoV-2 infection in a patient on maintenance dialysis who presented with fever and lung edema. | 2020-08-04 |
| 32743952 | COVID-19 outbreak prompted health centres to reorganize their clinical and surgical activity. […] Current pandemic made us familiar with telemedicine, laying the foundations for its application to deal with the increasing number of requests in clinical genetics. | 2020-08-04 |
| 32743995 | We assessed the clinical outcomes of patients with COVID-19 during the first wave of the epidemic in Korea. […] Using a modified World Health Organization clinical record form, we obtained clinical data for 3,060 patients with COVID-19 treated at 55 hospitals in Korea. | 2020-08-04 |
| 32744242 | Patterns of clinical consultation have changed, including a greater level of virtual visits, physical spacing, masking, staffing changes to ensure a COVID-free population and significant changes in patterns of family involvement. | 2020-08-04 |
| 32744465 | Thus the current manuscript aims to describe all three (SARS, MERS, and COVID-19) in terms of their causal organisms (SARS-CoV, MERS-CoV, and SARS-CoV2), similarities and differences in their clinical symptoms, outcomes, immunology, and immunopathogenesis, and possible future therapeutic approaches. | 2020-08-04 |
| 32744563 | Patients at high risk of adverse clinical outcomes in COVID-19 infection are the same at risk of malnutrition, namely older adults and multimorbid individuals. | 2020-08-04 |
| 32744565 | Bernard Isaacs described the “Geriatric Giant Symptoms” in 1965 and encouraged the development of interventions for immobility, instability, incontinence and impaired intellect/memory with careful management of these symptoms resulting in better outcomes for older patients including reduced admissions to Nursing Homes and mortality. […] Moreover delayed access to day patient services with suboptimal access to assessments for conditions such as cognitive decline and falls as well as social care will likewise militate against addressing the “Geriatric Giant Symptoms”. […] Thus the “Founding Fathers” of Geriatric Medicine including Prof Isaacs would be justifiably concerned regarding our ability to deliver interventions to address the “Geriatric Giant Symptoms”. | 2020-08-04 |
| 32744612 | These findings suggest that practitioners and public health officials should emphasize the importance of visiting the ED during the COVID-19 pandemic for serious symptoms, illnesses, and injuries that cannot be managed in other settings. | 2020-08-04 |
| 32744708 | To evaluate the clinical manifestations and outcomes of neonates born to women who had Coronavirus Disease 2019 (COVID-19) during pregnancy. | 2020-08-04 |
| 32744709 | So, both primary and clinical scientists are not only trying to decipher the structure of SARS-CoV-2, but also attempting to understand the underlying molecular mechanisms that cause tissues and cell injuries. | 2020-08-04 |
| 32744710 | This study aims to investigate the clinical characteristics and outcomes of COVID-19 patients admitted at different time periods. […] Individual data, clinical data, laboratory indices and prognosis were collected for the two groups, and statistical analysis was performed using the t-test or chi-square test to assess differences between the groups. […] According to the individual data and clinical manifestations of the two groups, the hospital stay in the first group was significantly longer than that of the second group (26 [9-39] compared with 20 [6-30], p=0.000). […] There were more clinical symptoms upon admission in group 1 than in group 2; although 66.2% of all patients had fever, the proportion of patients with fever on admission in the first group was significantly higher than that in the second group (79.1% compared with 54.7%, p=0.002). […] Four of the 67 patients in the first group had symptoms of ocular discomfort, but none in the second group had this symptom (6.0% compared with 0, p=0.032). […] The clinical manifestations, blood changes and outcomes differed in patients admitted at different time periods. […] In the second group of patients, clinical symptoms were less common than in the first group, routine blood changes and inflammatory indices were milder, and the clinical prognosis was better. | 2020-08-04 |
| 32744714 | Clinical, laboratory, and radiological data were collected from the 8th of March to the 8th of April 2020. […] We aimed to describe the most frequent clinical and laboratory features and predictors of death among patients admitted to our Unit. 87 patients were enrolled, 56 (64.4%) were male, with a median age of 72 (IQR 62.5-83.5) years. […] The most common symptoms were fever and dyspnoea. […] Furthermore, therapy choice and timing in this challenging setting should be urgently investigated in randomized clinical trials. | 2020-08-04 |
| 32744716 | Infection-associated symptoms are very similar between SARS and COVID-19 diseases and are the same as community-acquired pneumonia symptoms. | 2020-08-04 |
| 32744717 | Progress in the management of ICU is crucial for a decrease in the mortality of critically ill patients with COVID-19 with the clinical evidence and experience updated. | 2020-08-04 |
| 32744841 | Around a quarter of participants demonstrated significantly elevated anxiety and depression, with 14.8% reaching clinical cutoff for health anxiety. | 2020-08-04 |
| 32744917 | The review also highlights their advantages, disadvantages, and clinical utility for the treatment of COVID-19 patients. […] The research and investment need to be accelerated to bring them into clinical use for prophylactic and therapeutic purposes against COVID-19. | 2020-08-04 |
| 32744939 | Clinical care in the United States has been transformed during the coronavirus disease 2019 (COVID-19) pandemic. | 2020-08-04 |
| 32745013 | Symptoms-based screening and manual contact tracing have limitations that render them ineffective for containing the viral spread in LTC facilities. […] Symptoms-based screening alone cannot identify asymptomatic people who are infected, and the viral spread is too fast in confined living quarters to be contained by slow manual contact tracing processes. | 2020-08-04 |
| 32745068 | Here we evaluated the analytical and clinical performance of three commercially available SARS-CoV-2 antibody assays. | 2020-08-04 |
| 32745217 | The survey collected demographic and practice information as well as responses regarding several clinical practice issues. | 2020-08-04 |
| 32745237 | Triage will not detect patients who are showing no symptoms but who are developing the disease, so the hospital should provide an on-call expert team to discuss inpatients suspected or diagnosed with COVID-19 and refer them to radiology, respiratory or intensive care colleagues as required. | 2020-08-04 |
| 32745249 | The disease can affect different organ systems, and early reports have suggested skin symptoms. […] The researchers, working with dermatologists across Spain, reviewed 375 patients with suspected, or confirmed, COVID-19, with the aim of developing a detailed classification of the different types of skin symptoms associated with COVID-19 with corresponding images. […] An initial 120 images were reviewed by four dermatologists, without knowing any other clinical information, and they identified patterns of symptoms associated with COVID-19. […] Five common skin symptoms were identified this way. […] These symptoms are chilblain-like lesions, outbreaks of small blisters, wheals, rashes comprised of small flat and raised red bumps, and livedo and necrosis. […] These symptoms are associated with different severity of COVID-19 infection, from less severe disease in the chilblain-like lesions, to most severe in patients with livedo. […] The researchers noted that some of the skin symptoms associated with COVID-19 are common and can have many causes, particularly wheals and rashes. | 2020-08-04 |
| 32745308 | Data of demographics, clinical characteristics, comorbidities, laboratory tests, medications and outcomes were collected and analyzed. | 2020-08-04 |
| 32745512 | Participants were voluntary users of the app and at first use provided information on demographic factors (including age, sex, race or ethnic background, height and weight, and occupation) and medical history, and subsequently reported any COVID-19 symptoms. […] Secondary and post-hoc analyses suggested adequacy of PPE, clinical setting, and ethnic background were also important factors. | 2020-08-04 |
| 32745595 | Sensitivity for all assays was 100% (95% confidence interval 83.7-100) 3 weeks after onset of symptoms. […] Seroconversion occurred within 3 weeks after onset of symptoms with all assays and on average 2 days earlier for assays detecting IgG or total Ig anti-N than for IgG anti-S. | 2020-08-04 |
| 32745693 | We established an international consortium to review and discuss relevant clinical evidence in order to develop expert consensus statements related to cancer management during the severe acute respiratory syndrome coronavirus 2-related disease (COVID-19) pandemic. […] The steering committee prepared 10 working packages addressing significant clinical questions from diagnosis to surgery. […] Overall, the expert panel agreed on 28 consensus statements that can be used to overcome many of the clinical and technical areas of uncertainty ranging from diagnosis to therapeutic planning and treatment during the COVID-19 pandemic. | 2020-08-04 |
| 32745719 | However, there were clear individual differences: approximately 25% of participants reported that their sleep quality had worsened, which was explained by stress vulnerability, caregiving, adverse life impact, shift work, and presence of COVID-19 symptoms. | 2020-08-04 |
| 32745794 | Depression, anxiety, and PTSD symptoms, as well as COVID-19-related concerns, sleep problems, and quality of life were compared across the following pre-existing mental health groups: 1) no diagnosis, 2) suspected diagnosis, 3) diagnosed and untreated, and 4) diagnosed and treated. […] Compared to those without a diagnosis, the likelihood of scoring above the clinical threshold for those with a diagnosis - whether treated or not - was more than six-fold for depression, and four-to six-fold for anxiety and PTSD. […] Individuals with a suspected diagnosis were 3 times more likely to score above the clinical threshold for depression and anxiety and 2 times more as likely to score above this threshold for PTSD compared to those with no diagnosis. | 2020-08-04 |
| 32745795 | This is a cross-sectional study evaluating the associations of self-reported moderate to vigorous physical activity, and sedentary behavior with depressive, anxiety, and co-occurring depressive and anxiety symptoms (D&A) in self-isolating Brazilians during the COVID-19 pandemic. […] Depressive and anxiety symptoms were collected using the Beck Depression and Anxiety Inventories (BDI and BAI). […] Among the 937 participants (females=72.3%), those performing ≥30 min/day of moderate to vigorous or ≥15 min/day of vigorous physical activity had lower odds of prevalent depressive, anxiety, and co-occurring D&A symptoms. […] Those spending ≥10 h/day sedentary were more likely to have depressive symptoms. | 2020-08-04 |
| 32745895 | So far, only a few studies evaluated the correlation between CT features and clinical outcome in patients with COVID-19 pneumonia. […] We evaluated the differences between the two groups for clinical, laboratory and CT data. […] Lung disease extension, assessed using quantitative CT, has a significant relationship with clinical severity and may predict the need for invasive ventilation in patients with COVID-19. | 2020-08-04 |
| 32746481 | In this review, we summarize the current knowledge about the coronavirus, disease epidemiology, clinical manifestations and risk factors, replication of the virus, pathophysiology and host immune responses of SARS-CoV-2 infection. | 2020-08-04 |
| 32746638 | The sleep problems of the children with ASD during the home confinement period mediated the relationship between chronotype score and severity of autism symptoms. | 2020-08-05 |
| 32746653 | Research should be focused on the development of anti-SARS-CoV-2 drugs and vaccines based on high-quality clinical trial evidence, treatment guidelines and expert consensus. | 2020-08-05 |
| 32746685 | Objective: To study symptoms and symptom relief during the last week of life, comparing nursing homes with hospitals. […] Breakthrough symptoms were registered as Yes/No. | 2020-08-05 |
| 32746701 | The upstream causes of the COVID-19 pandemic have received little attention so far in public health and clinical medicine, as opposed to the downstream effects of mass morbidity and mortality. | 2020-08-05 |
| 32746711 | Nursing is a profession frequently acknowledged as practicing on “the front lines of care” and frequently responsible for the trialing of products in clinical settings. | 2020-08-05 |
| 32746738 | To describe a remote approach used with patients with voice prosthesis after laryngectomy during the COVID-19 pandemic and the resulting clinical outcomes in terms of voice prosthesis complications management, oncological monitoring, and psychophysical well-being. | 2020-08-05 |
| 32746750 | Most of the studies used e-health technologies to facilitate clinical decision support and team care. | 2020-08-05 |
| 32746761 | RNs improve quality outcomes in primary care within innovative team-based care models and are essential clinicians capable of providing ongoing care coordination and disease management for patients needing to stay on track with their usual care needs. | 2020-08-05 |
| 32746801 | In this study, we systematically reviewed the clinical features and outcomes of pregnant women with COVID-19. | 2020-08-05 |
| 32746805 | To assess the dynamic changes in clinical and CT characteristics of COVID-19 patients with different epidemiology histories. […] The CT and laboratory findings were compared between and within groups during the clinical process. | 2020-08-05 |
| 32746913 | The objective of this study will be to summarize the recommendations in current clinical practice guidelines about the use of traditional Chinese herbal medicine for COVID-19 patients. […] In this systematic review, we will search for guidelines, expert consensuses, and policy documents published since December 2019 in electronic databases (e.g., PubMed, EMBASE, and Chinese databases) and on websites of governments or organizations (e.g., The National Guideline Clearinghouse [NGC], Guidelines International Network [GIN], National Institute for Health and Clinical Excellence (NICE), Scottish Intercollegiate Guidelines Network [SIGN], and WHO). […] This review will summarize the recommendations in current clinical practice guidelines and provide insight into the implementation strategies for traditional Chinese herbal medicine in COVID-19 patients. | 2020-08-05 |
| 32746922 | A third virus, the H5N1, responsible for avian influenza, has caused infection with some clinical similarities to those in COVID-19 infections. […] Clustering of cytokine-disease co-occurrences in the context of Coronavirus has identified compelling clusters of co-morbidities and symptoms, some of which already known to be linked to COVID-19. […] Finally, network analysis identified sub-networks of cytokines and immune cell types associated with different manifestations, co-morbidities and symptoms of Coronavirus, SARS, and H5N1. | 2020-08-05 |
| 32746940 | This study aimed to analyse the clinical characteristics and abnormal immunity of the confirmed COVID-19 non-survivors. […] The demographic, clinical characteristics and laboratory findings at admission, and treatment used in these patients were collected. […] The common signs and symptoms at admission of non-survivors were fever (88%), followed by cough (64.8%), dyspnea (62.4%), fatigue (62.4%) and chest tightness (58.4%). | 2020-08-05 |
| 32746957 | This study aimed to identify clinical features for prognosing mortality risk using machine-learning methods in patients with coronavirus disease 2019 (COVID-19). […] The data of symptoms, comorbidity, demographic, vital sign, CT scans results and laboratory test results on admission were collected. […] Machine-learning methods (Random Forest and XGboost) were used to rank clinical features for mortality risk. […] Multivariate logistic regression models were applied to identify clinical features with statistical significance. | 2020-08-05 |
| 32747012 | In this retrospective, single-center study, 27 COVID-19 patients with hypertension, who were admitted to the Shanghai Public Health Clinical Center from January 25, 2020 to January 31, 2020, were analyzed for clinical features, laboratory parameters, medications and the length of stay. […] Comparing the two groups, we did not found statistically significant differences in clinical symptoms and laboratory tests. | 2020-08-05 |
| 32747157 | The development of lethal clinical symptons is associated with an exaggerated production of inflammatory cytokines, referred to as the cytokine storm, is a consequence of a hyperactivated immune response aginst the infection. | 2020-08-05 |
| 32747164 | Academic detailing, a peer-to-peer collaborative outreach designed to improve clinical decision-making, has traditionally relied on in-person encounters for effectiveness. […] Moreover, VA academic detailers are primarily clinical pharmacy specialists who provide clinical services and education and have made meaningful contributions to improving health care at VA. | 2020-08-05 |
| 32747181 | Medical schools were upended by the COVID-19 pandemic, resulting in suspension of all in-person educational activities, and leaving clinical clerkships on hold indefinitely. | 2020-08-05 |
| 32747185 | Antibodies against SARS-CoV-2 were detected in virtually all hospital staff sampled from 13 days after the onset of COVID-19 symptoms. | 2020-08-05 |
| 32747387 | Healthcare providers commonly experience symptoms of anxiety during public health crises and pandemics. […] The objective of the study was to identify the frequency of symptoms of generalized anxiety disorder (GAD) in general practitioners and to estimate the association with particular psychosocial and demographic factors. […] The presence of symptoms of GAD was defined by a GAD-7 score of 10 or more points. […] Symptoms of GAD were identified in 4 out of 10 Colombian general practitioners; the following psychosocial and demographic factors were associated with a greater presence of these symptoms: female gender, social discrimination, anguish, job disappointment, nightmares, stress and other symptoms of fear regarding the pandemic. […] Conversely, feeling protected by the state or employer, being satisfied with their job as a physician, and trusting government measures and information were associated with a lower presence of symptoms of GAD. | 2020-08-05 |
| 32747391 | Clinical data indicate that severe COVID-19 most commonly manifests as viral pneumonia-induced acute respiratory distress syndrome (ARDS), a clinical entity mechanistically understood best in the context of influenza A virus-induced pneumonia. […] In this review we connect the current understanding of the SARS-CoV-2 replication cycle and host response to the clinical presentation of COVID-19, borrowing concepts from influenza A virus-induced ARDS pathogenesis and discussing how these ideas inform our evolving understanding of COVID-19-induced ARDS. […] We also consider important differences between COVID-19 and influenza, mainly the protean clinical presentation and associated lymphopenia of COVID-19, the contrasting role of interferon-γ in mediating the host immune response to these viruses, and the tropism for vascular endothelial cells of SARS-CoV-2, commenting on the potential limitations of influenza as a model for COVID-19. | 2020-08-05 |
| 32747830 | The results highlight the value of using a multimodal analytical approach to reveal determinants and predictors of immunity, susceptibility and clinical outcome associated with infection. | 2020-08-05 |
| 32747875 | The purpose of this study is to identify the clinical features of myocarditis in COVID-19 patients. […] The majority of studies reported either recovery or no further clinical deterioration. | 2020-08-05 |
| 32747912 | This case provides the opportunity to study the natural evolution of COVID-19 pneumonia in a young person with clinical signs of pneumonia but without associated comorbidities. | 2020-08-05 |
| 32747923 | The study considers the ethical review of the European Union (EU) clinical trials (CTs) legislation, namely the Clinical Trials Regulation (CTR) (EU) 2014∕536, the Directive 2001∕20∕EC and the “Guidance on the management of clinical trials during the COVID-19 (coronavirus) pandemic” (GMCT) (version 3) issued on 28 April 2020 by the European authorities in the field. […] The present article displays the ethical requirements for conducting, monitoring and reporting of the CTs by raising awareness on the: (i) new conceptual framework of the “clinical trial”, “low-intervention clinical trial”, “non-interventional study” and “ethics committee”; (ii) ethical considerations addressed in Part I and Part II of the assessment report; (iii) evaluation of the coronavirus disease 2019 (COVID-19) pandemic on the current regulatory framework. […] The CTR stimulates the EU clinical research and enables an independent control with regard to the respect of the interests of the CT subject. | 2020-08-05 |
| 32747962 | Medical school administrators had to make swift and judicious decisions that would best serve the student body and the diverse patient population at clinical sites. | 2020-08-05 |
| 32748176 | After the 7th day of image acquisition, the daily rate of patients whose images allowed clinical decision was maintained above 80%. […] Daily rate of patients whose examinations allowed clinical decision. […] X-axis: day of examination; Y-axis: rate (%) of patients whose examinations allowed a clinical decision. | 2020-08-05 |
| 32748244 | This data includes previously used strategies against infectious disease, recent clinical trials and FDA-approved diagnostic and treatment strategies. | 2020-08-05 |
| 32748252 | A radiologist blinded to the clinical outcome evaluated single axial slice on CT at L3 vertebral body for VATL3, SATL3, TATL3, and VAT/TATL3. […] A clinical model that included age, sex, and BMI was compared to clinical + CT model that also included VATL3 to discriminate hospitalized patients from outpatients. […] Area under the curve (AUC) of the clinical + CT model was higher compared to the clinical model (AUC 0.847 versus 0.750) for identifying patients requiring hospitalization. […] Higher VATL3 was observed in COVID-19 patients that required hospitalization compared to the outpatients, and addition of VATL3 to the clinical model improved AUC in discriminating hospitalized from outpatients in this preliminary study. | 2020-08-05 |
| 32748331 | Although various clinical trials are being conducted on renin- angiotensin- system inhibitor, till to date there is no standard treatment protocol approved for critically ill COVID-19 positive cases with pre-existing hypertension. | 2020-08-05 |
| 32748333 | In our experience, COVID-19 associated with HIV infection had a clinical presentation comparable to the general population and was frequently associated with chronic comorbidities. | 2020-08-05 |
| 32748336 | Herein, we have comprehensively reviewed the current literature available on CAC and highlight the pathogenesis, clinical features, and management of CAC. | 2020-08-05 |
| 32748568 | Further inclusive research aimed at optimizing clinical care relevant to the African American population is critical to ensure an equitable response to COVID-19. | 2020-08-05 |
| 32748740 | Once the efficacy of the drug is determined, it can be approved for of their in vitro and in vivo activity against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), that could be interesting for rapid clinical treatment of patients. […] However, the assessment of these potential inhibitors as clinical drugs involves further in vivo tests for these drugs. | 2020-08-05 |
| 32748880 | We designed an on-line survey with 30 questions to assess physicians’ perception of personal impact as well as epidemiology, clinical features, management, and outcome in COVID-19. | 2020-08-05 |
| 32749010 | Laboratory data were compared with clinical data and outcomes. | 2020-08-05 |
| 32749040 | In University Hospital La Paz (Madrid, Spain), we reviewed the clinical and demographic characteristics of 10 patients with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) PCR and Aspergillus spp. isolate in respiratory samples. […] This clinical entity has high mortality, and therefore, it should be performed surveillance with early galactomannan tests and cultures in respiratory samples in order to improve the outcome of the patients with this condition. | 2020-08-05 |
| 32749095 | Based on the available literature, I propose that MAIT cells regulate the host response to SARS-CoV-2 and constitute attractive targets in the prevention or clinical management of coronavirus disease 19 (COVID-19) and some of its complications. | 2020-08-05 |
| 32749165 | Didactic sessions have transitioned to electronic/online platforms and clinical teaching opportunities are limited. […] These changes will affect how radiology is taught to medical students at both the pre-clerkship (ie, year 1 and 2) and clinical (ie, year 3 and 4) levels. […] In the pre-clerkship learning environment, medical students are typically exposed to radiology through didactic lectures, integrated anatomy laboratories, case-based learning, and ultrasound clinical skills sessions. […] In the clinical learning environment, medical students primarily shadow radiologists and radiology residents and attend radiology resident teaching sessions. | 2020-08-05 |
| 32749177 | Clinical characteristics, the course and the outcome of patients with diarrhea were analyzed. […] Among them, 38 cases presented only with diarrhea, and 119 cases in both diarrhea and respiratory symptoms. […] Patients with diarrhea and respiratory symptoms had higher levels of inflammatory activity, longer hospital stay (27.5 vs. […] 22.0 days, p = .029) and higher odds ratio of mortality (3.2 times and 2.2 times, respectively) than those with diarrhea only or respiratory symptoms only. […] 52.4%, p = .016) than those with both diarrhea and respiratory symptoms. […] The patients with diarrhea and respiratory symptoms were prone to serious condition, and had worse outcomes. | 2020-08-05 |
| 32749247 | The pathological consequences of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) are multiple, with interstitial pneumonia and consecutive respiratory failure being the most dangerous clinical manifestations. […] In the second part, the main echographic findings, their interpretation, and the clinical applications of LUS are overviewed. | 2020-08-05 |
| 32749530 | To collect paediatric COVID-19 cases worldwide and to summarize both clinical and imaging findings in children who tested positive on polymerase chain reaction testing for SARS-CoV-2. […] Most had mild symptoms, mostly fever and cough, and one-third had coexisting medical conditions. […] Eleven percent of children presented with severe symptoms and required intensive unit care. […] CT should be reserved for when there is clinical concern to assess for possible complications, especially in children with coexisting medical conditions. | 2020-08-05 |
| 32749568 | These impacts may be heightened for families whose caregivers experience increased mental health symptoms, as was the case for fathers in the current sample. | 2020-08-05 |
| 32749601 | Neurological symptoms of COVID-19 patients have been recently described. | 2020-08-05 |
| 32749606 | There are numerous reports on the frequent findings of sudden anosmia or hyposmia, before or at the same time of the typical COVID-19 symptoms onset. […] The aim of this study was to verify the association of olfactory impairment and COVID-19, providing a basis for subsequent research in the field of COVID-19 clinical heterogeneity. […] SOL was identified as a significant sign of infection in COVID-19 patients, mainly aged between 30 and 40 years, even in the absence of other symptoms. | 2020-08-05 |
| 32749643 | The relationship of GI and hepatic involvement with severe clinical course of COVID-19 has also not been explored. […] The main objectives were to determine the frequency of GI and hepatic manifestations of COVID-19 and to explore their relationship with severe clinical course. […] These data were compared between patients with severe and good clinical course using the random-effects model and odds ratio (OR) as the effect size. […] Up to 20% patients developed severe clinical course, and GI and hepatic factors associated with severe clinical course were as follows: diarrhea (OR 2), high aspartate aminotransferase (OR 1.4), high alanine aminotransferase (OR 1.6), high bilirubin (OR 2.4), low albumin (OR 3.4), and high PT (OR 3). […] GI and hepatic involvement should be sought in patients with COVID-19 since it portends severe clinical course. | 2020-08-05 |
| 32749705 | Studies reporting smoking status of hospitalized patients with different severities of disease and/or at least one clinical endpoint of interest (disease progression, intensive care unit admission, need for mechanical ventilation, and mortality) were included. | 2020-08-05 |
| 32749712 | To our knowledge, this is the first report of placental SARS-CoV-2 despite mild COVID-19 disease (no symptoms of COVID-19 aside from myalgias); patient had no fever, cough, or shortness of breath, but only myalgias and sick contacts. […] This raises important questions of whether future pregnancy guidance should include stricter pandemic precautions, such as screening for a wider array of COVID-19 symptoms, increased antenatal surveillance, and possibly routine COVID-19 testing throughout pregnancy. | 2020-08-05 |
| 32749822 | Better differentiation of suicidality can help clinical practice to offer tailored treatment and prevention. | 2020-08-05 |
| 32749996 | In response to the rapidly evolving body of evidence, a solid communication strategy is needed to increase the reach of and adherence to locally drafted and validated guidance to aide medical staff with COVID-19-related clinical decisions. | 2020-08-05 |
| 32750000 | The aim of this study is to evaluate the clinical characteristics and outcomes of pregnant and nonpregnant women with COVID-19. […] This study retrospectively collected epidemiological, clinical, laboratory, imaging, management, and outcome data of 43 childbearing-age women patients (including 17 pregnant and 26 nonpregnant patients) who presented with laboratory-confirmed COVID-19 in Tongji Hospital, Wuhan, China from January 19 to March 2, 2020. […] Clinical outcomes were followed up to March 28, 2020. […] Fever (8/17, 47% vs 18/26, 69%) and cough (9/17, 53% vs 12/26, 46%) were common onsets of symptoms for the two groups. […] The epidemiology and clinical and laboratory features of pregnant women with COVID-19 were diverse and atypical, which increased the difficulty of diagnosis. | 2020-08-05 |
| 32750009 | Reliably identifying patients at increased risk for coronavirus disease (COVID-19) complications could guide clinical decisions, public health policies, and preparedness efforts. […] This study aimed to identify factors associated with COVID-19 complications from the complete medical records of a nationally representative cohort of patients, with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. […] We studied a cohort of all SARS-CoV-2-positive individuals, confirmed by polymerase chain reaction testing of either nasopharyngeal or saliva samples, in a nationwide health organization (covering 2.3 million individuals) and identified those who suffered from serious complications (ie, experienced moderate or severe symptoms of COVID-19, admitted to the intensive care unit, or died). | 2020-08-05 |
| 32750010 | The goal of this study was to develop, validate, and scale a clinical decision support system and mobile app to assist in COVID-19 severity assessment, management, and care. […] Our results demonstrate the validity of the clinical decision support system and mobile app, which are now ready to assist health care providers in making evidence-based decisions when managing COVID-19 patient care. | 2020-08-05 |
| 32750012 | Cancer diagnoses and treatments usually engender significant anxiety and depressive symptoms in patients, close relatives, and caregivers. […] Prevalence of anxiety and depressive symptoms, their demographic correlates, and Text4Hope-Cancer Care-induced changes in anxiety and depression will be evaluated. […] Self-administered, anonymous, online questionnaires will be used to assess anxiety and depressive symptoms using the Hospital Anxiety and Depression Scale (HADS). […] Data will be analyzed with parametric and nonparametric statistics for primary outcomes (ie, anxiety and depressive symptoms) and usage metrics, including the number of subscribers and user satisfaction. […] In addition, data mining and machine learning analysis will focus on determining subscriber characteristics that predict high levels of symptoms of mental disorders, and may subsequently predict changes in those measures in response to the Text4Hope-Cancer Care program. […] Text4Hope-Cancer Care has the potential to provide key information regarding the prevalence rates of anxiety and depressive symptoms in patients diagnosed or receiving care for cancer and their caregivers. | 2020-08-05 |
| 32750019 | In patients with positive PCR test but not showing clinical signs, the reduction of immunosuppression is not advised. […] The efficacy and tolerability of hidroxychloroquin remains to be also questionable; enroll patients into clinical trial with remdesivir or favipiravir if available. | 2020-08-05 |
| 32750072 | N = 949 subjects completed an online-survey that asked for symptoms regarding depression, (health) anxiety, panic disorder, obsessive-compulsive disorder, and lock-down related behavior-starting 14 days after lockdown in Germany. | 2020-08-05 |
| 32750108 | Here, the Working Group on Atherosclerosis and Vascular Biology together with the Council of Basic Cardiovascular Science of the European Society of Cardiology provide a Position Statement on the importance of the endothelium in the underlying pathophysiology behind the clinical presentation in COVID-19 and identify key questions for future research to address. | 2020-08-05 |
| 32750184 | Pregnancy outcomes included gestational diabetes (National Institute of Health and Clinical Excellence or International Association of Diabetes and Pregnancy Study Groups criteria), diabetes in pregnancy (WHO criteria), Caesarean section, large-for-gestational age infant, neonatal hypoglycaemia and neonatal intensive care unit admission. […] Gestational diabetes diagnosis was significantly associated with random plasma glucose at 12 weeks [area under the receiver-operating characteristic curve for both criteria 0.81 (95% CI 0.79-0.83)], fasting plasma glucose [National Institute of Health and Clinical Excellence: area under the receiver-operating characteristic curve 0.75 (95% CI 0.65-0.85); International Association of Diabetes and Pregnancy Study Groups: area under the receiver-operating characteristic curve 0.92 (95% CI 0.85-0.98)] and HbA1c at 28 weeks’ gestation [National Institute of Health and Clinical Excellence: 0.83 (95% CI 0.75-0.90); International Association of Diabetes and Pregnancy Study Groups: 0.84 (95% CI 0.77-0.91)]. | 2020-08-05 |
| 32750201 | Although Hubei province is the epicenter of China, little is known about epidemiological and clinical features of COVID-19 in other areas in Hubei province around Wuhan. […] To describe the epidemiological and clinical features of patients with COVID-19 in Tianmen city, and identify risk factors associated with prolonged viral shedding of COVID-19. […] Symptoms of patients from Tianmen are relatively mild. […] In addition, clinical trials on arbidol should be conducted to demonstrate its effectiveness. | 2020-08-05 |
| 32750438 | A thorough search strategy was applied to identify published research trials in PubMed, Scopus, Medline, and EMBASE from Dec 1, 2019, to May 4, 2020, for studies reporting clinical outcomes of COVID-19 patients treated with immunotherapies along with other standard cares. […] From an initial screen of 80 identified studies, 24 studies provided clinical outcome data on the use of immunotherapies for the treatment of COVID-19 patients, including convalescent plasma therapy (33 patients), monoclonal antibodies (55 patients), interferon (31 patients), mesenchymal stem cell therapy (8 patient), and immunoglobulin (63 patients). […] Except for nine severe patients who died after treatment, most patients were recovered from COVID-19 with improved clinical symptoms and laboratory assessment. […] Based on the available evidence, it seems that treatment with immunotherapy along with other standard cares could be an effective and safe approach to modulate the immune system and improvement of clinical outcomes. | 2020-08-05 |
| 32750451 | Type 2 diabetes mellitus (T2DM) is associated with both poorer clinical outcomes during the COVID-19 pandemic and an increased risk of death in such hospitalized patients. | 2020-08-05 |
| 32750604 | Early quality improvement data regarding virtual visit volumes and clinical insights from our outpatient psychiatry department located within a large, urban, tertiary care academic medical center reflect both the opportunities and challenges of virtual care for patients and providers. […] Notable benefits have included robust clinical volumes despite social distancing mandates, reduced logistical barrieres to care for many patients, and decreased no-show rates. […] Finally, we provide clinical suggestions for optimizing telepsychiatry based on our experience, make a call for advocacy to continue the reduced insurance and regulatory restrictions affecting telepsychiatry even once this public health crisis has passed, and pose research questions that can help guide optimal utilization of telepsychiatry as mainstay or adjunct of outpatient psychiatric treatment now and in the future. | 2020-08-05 |
| 32750726 | Clinical studies clearly indicate that endometriosis is a condition associated with high levels of chronic stress. | 2020-08-05 |
| 32750752 | At the start of the COVID-19 pandemic in March 2020, fever and respiratory symptoms were the indications for virus testing in our hospital. […] As data have continued to accumulate worldwide, gastrointestinal, neurological, cardiovascular, cutaneous and ocular symptoms have been reported for confirmed COVID-19 cases. […] However, new symptoms can provide diagnostic and testing criteria for patients with no other clinical presentation, especially in older children. | 2020-08-05 |
| 32751400 | Infections with SARS-CoV-2 can result in severe clinical manifestations. | 2020-08-06 |
| 32751615 | Its clinical manifestations are characterized by a heterogeneous group of symptoms and pictures (ranging from asymptomatic to lethal courses). | 2020-08-06 |
| 32751624 | A total of 56.6% of health workers present symptoms of posttraumatic stress disorder, 58.6% anxiety disorder, 46% depressive disorder and 41.1% feel emotionally drained. […] The profile of a health worker with greater posttraumatic stress symptoms would be a person who works in the Autonomous Community of Madrid, in a hospital, is a woman, is concerned that a person he/she lives with may be infected, and thinks that he/she is very likely to be infected. | 2020-08-06 |
| 32751633 | The author examines the underlying clinical implications that may predispose minority populations and the adverse clinical outcomes that may contribute to increased risk of mortality. | 2020-08-06 |
| 32751841 | Overall, these papers report that patients may exhibit a wide range of neurological manifestations, including encephalopathy, encephalitis, seizures, cerebrovascular events, acute polyneuropathy, headache, hypogeusia, and hyposmia, as well as some non-specific symptoms. | 2020-08-06 |
| 32752123 | Epidemiological and clinical data were collected. […] Potential associations between olfactory evaluation and the clinical outcomes (duration of hospitalization; admission biology; one month serology (IgG), and chest computed tomography findings) were studied. | 2020-08-06 |
| 32752129 | Furthermore, the clinical picture that has been described in these patients is far from the severity that experts would expect. […] In this picture, the angiotensin-converting enzyme 2 plays an essential role, being directly involved in the pathophysiology of both clinical entities. | 2020-08-06 |
| 32752217 | One line of research relates to the role of micronutrients, food components, and diets in the strengthening of the immune system through clinical trials; formulations could be developed as immune system enhancers or as co-adjuvants in therapies. […] This line requires, as a first step, an in silico evaluation to discover lead compounds, which may be further developed through drug-design studies, in vitro and in vivo tests, and, finally, clinical trials to obtain therapeutic molecules. | 2020-08-06 |
| 32752556 | Specific patient criteria for the LAHS were established, staffing was prioritized, and clinical protocols were designed to facilitate care. | 2020-08-06 |
| 32752587 | In addition to poor clinical outcomes, such measures have profound negative effects on the mental health of older populations. | 2020-08-06 |
| 32752938 | As these drugs are well tolerated, cost-effective, and widely used, our study suggests that they could potentially to be used in clinical trials for the treatment of SARS-CoV-2-infected patients. | 2020-08-06 |
| 32752944 | Furthermore, possible mode of action, efficacy and current stage of clinical trials of various drug combinations against COVID-19 disease has also been discussed in detail. | 2020-08-06 |
| 32752970 | Therapies should be reserved for use in clinical trials, emergency or compassionate access until we gain more confidence in the balance of benefit and harm. | 2020-08-06 |
| 32753052 | Our cases highlight a novel clinical presentation of COVID-19 renal disease, not described before, that of new-onset nephrotic syndrome. | 2020-08-06 |
| 32753076 | Clinical features of both central and peripheral nervous system involvement are evident. | 2020-08-06 |
| 32753138 | To perform a systematic review and meta-analysis evaluating the prevalence of gastrointestinal (GI) symptoms and mortality in patients with coronavirus disease 2019 (COVID-19) diagnosed. […] Observational studies including adults with COVID-19 infection and reporting GI symptoms were included. […] The primary outcome was assessing the weighted pooled prevalence (WPP) of GI symptoms in patients with COVID-19 infection. […] Secondary outcomes were WPP of overall mortality, and mortality in patients with COVID-19 infection with GI symptoms. […] Among GI symptoms (at onset of illness in 6, at admission in 17, data given separately for both in 3, and data unavailable in 52 studies), the WPP of diarrhea was 12.4% (95% CI, 8.2% to 17.1%), I2=94%; nausea and/or vomiting, 9.0% (95% CI, 5.5% to 12.9%), I2=93%; loss of appetite, 22.3% (95% CI, 11.2% to 34.6%, I2=94%; and abdominal pain, 6.2% (95% CI, 2.6% to 10.3%), I2=92%. […] Mortality among patients with GI symptoms (0.4%; 95% CI, 0% to 1.1%; I2=74%) was similar to overall mortality (2.1%; 95% CI, 0.2% to 4.7%; I2=94%), P=.15. […] Gastrointestinal symptoms are seen in up to 1 in 5 patients with COVID-19 infection. | 2020-08-06 |
| 32753142 | The possibility of seasonality of COVID-19 is being discussed; we show clinical microbiology laboratory data illustrating seasonality of coronaviruses 229E, HKU1, NL63, and OC43. | 2020-08-06 |
| 32753146 | Telemedicine uses modern telecommunication technology to exchange medical information and provide clinical care to individuals at a distance. […] Initially intended to improve health care for patients in remote settings, telemedicine now has a broad clinical scope with the general purpose of providing convenient, safe, and time- and cost-efficient care. | 2020-08-06 |
| 32753148 | Physiologic changes in normal pregnancy and metabolic and vascular changes in high-risk pregnancies may affect the pathogenesis or exacerbate the clinical presentation of COVID-19. […] Medical therapy, during pregnancy and breastfeeding, relies on medications with proven safety, but safety data are often missing for medications in the early stages of clinical trials. | 2020-08-06 |
| 32753243 | We evaluated published information in peer-reviewed journals between January 1, 2020, and April 24, 2020, with available data on acute kidney injury (AKI), renal replacement therapy (RRT), intensive care unit (ICU) stay, and death and compared clinical outcomes in KTR vs nontransplant recipients with COVID-19. | 2020-08-06 |
| 32753338 | A total of 126 subjects were included in the study, the mean scores of PTSD-SS, SDS, and SAS were 45.5 ± 18.9, 47.3 ± 13.1, and 43.2 ± 10.2, respectively, meanwhile, 9 (31.0%), 28 (22.2%), and 48 (38.1%) of the survivors met the cut-score for clinical significant symptoms of stress response, anxiety, and depression, respectively. […] The survivors aged 60 or above experienced less severe stress response symptoms, fewer emotional symptoms of depression, and fewer anxiety symptoms than younger survivors. […] Besides, the results indicated the older survivors suffered less emotional reactivity and fewer stress response symptoms from infectious diseases than the younger ones. | 2020-08-06 |
| 32753340 | Moderate to severe baseline depressive symptoms reached remission levels after both courses. […] The 600-pulses aiTBS treatment protocol reported here warrants further study and evaluation, but may be a potential option in cases where older adults with severe depressive symptoms cannot access ECT during the COVID-19 pandemic. | 2020-08-06 |
| 32753347 | Researchers assessed the associations between depression symptoms (Patient Health Questionnaire-9), anxiety symptoms (Chinese version of the 7-item Generalized Anxiety Disorder scale), and social support (Social Support Rate Scale). […] COVID-19 exposure was associated with a higher prevalence of depression symptoms (odds ratio [OR] = 1.38, 95% confidence interval [CI]: 1.14-1.66) and anxiety symptoms (OR = 1.26, 95% CI: 1.04-1.52). […] Low support was associated with higher prevalence of depression (OR = 4.24, 95% CI: 3.38-5.33) and anxiety symptoms (OR = 3.18, 95% CI: 2.54-3.98), while controlling for gender, grade, living situation, and COVID-19 exposure; similarly, medium support was associated with higher prevalence of depression (OR = 2.79, 95% CI: 2.48-3.15) and anxiety (OR = 2.19, 95% CI: 1.94-2.48) symptoms. | 2020-08-06 |
| 32753375 | After abstract review, five papers were found to answer this clinical question using the detailed search strategy. | 2020-08-06 |
| 32753393 | In response, clinical staff and resources have been redeployed to the areas of greatest need, that is, intensive care units and emergency rooms (ER), to reinforce front-line manpower. | 2020-08-06 |
| 32753516 | We aimed to provide an independent review of clinical features of patients who died during hospitalisation with a positive PCR test for SARS-CoV-2 and relate these to the reported cause of death. | 2020-08-06 |
| 32753537 | Clinical training has adapted to ensure geographically dispersed medical personnel are trained while social distancing is maintained. […] The perceived benefits of webinar-based training included reduced travel time, more training continuity and greater clinical development of learners. | 2020-08-06 |
| 32753638 | Individuals with spinal cord injury (SCI) develop systemic physiological changes that could increase the risk of severe evolution of coronavirus disease 2019 (COVID-19) and result in atypical clinical features of COVID-19 with possible delay in both diagnosis and treatment. […] We evaluated differences in clinical features and evolution of COVID-19 between people with SCI and able-bodied individuals. […] We compared clinical information between patients with SCI and able-bodied healthcare workers of the same center who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the nasopharyngeal swab polymerase chain reaction. […] Nevertheless, no significant differences in clinical expression of COVID-19 and treatment strategies were observed between the two groups. […] This study does not support the supposed notion that COVID-19 could exhibit atypical clinical features or a worse evolution in the frail population of people with SCI. | 2020-08-06 |
| 32753857 | Therefore, health-care professionals should be aware of these, and screening policies for Covid-19 should also include atypical presentations with or without classical symptoms of the illness in older adults. | 2020-08-06 |
| 32754003 | COVID-19 disease with a high rate of contagious and highly nonspecific symptoms, is an infectious disease caused by a newly discovered coronavirus. […] Most people who fall sick with COVID-19 will experience mild to moderate symptoms such as respiratory symptoms, cough, dyspnea, fever, and viral pneumonia and recover without any special cure. | 2020-08-06 |
| 32754005 | Future healthcare systems will rely heavily on clinical decision support systems (CDSS) to improve the decision-making processes of clinicians. […] We show that CDSS may be used to analyze physiologic data for clinical event recognition and automated diagnosis, and we also highlight future research avenues for hospital CDSS. | 2020-08-06 |
| 32754041 | An early clinical report showed that fever, cough, fatigue, sputum production, and myalgia were initial symptoms, with the development of pneumonia as the disease progressed. | 2020-08-06 |
| 32754102 | Methods: Health professionals working in the hospitals of the Istituto Auxologico Italiano were asked to participate to an online anonymous survey investigating socio-demographic data, COVID-19 emergency-related work and psychological factors, state anxiety, psychological distress, post-traumatic symptoms and burnout. […] Two hundred and thirty-five health professionals (71.2%) had scores of state anxiety above the clinical cutoff, 88 (26.8%) had clinical levels of depression, 103 (31.3%) of anxiety, 113 (34.3%) of stress, 121 (36.7%) of post-traumatic stress. […] Conclusions: Health professionals had high levels of burnout and psychological symptoms during the COVID-19 emergency. | 2020-08-06 |
| 32754113 | The encountered neurological problems associated with SARS-CoV-2 infection were encephalopathy (12 patients, 36.4%), seizure (9 patients, 27.2%), stroke (5 patients, 15.2%), recrudescence of prior neurological disease symptoms (4 patients, 12.1%), and neuromuscular (3 patients, 9.1%). | 2020-08-06 |
| 32754114 | Demographic data, clinical and laboratory findings, comorbidities and treatments were collected and analyzed. […] Twenty patients (23.3%) had symptoms involving the central nervous system, including delirium, cerebrovascular diseases and hypoxic-ischemic brain injury, while 6 patients (7%) had neuromuscular involvement. […] Conclusions: The clinical spectrum of neurological complications in critically ill patients with COVID-19 was broad. | 2020-08-06 |
| 32754119 | Clinical information, laboratory findings, complications, treatment regimens, and mortality status were collected. | 2020-08-06 |
| 32754134 | However, next-generation sequencing has not been used for routine viral detection in clinical respiratory samples owing to its sophisticated technology. […] M3 acquired the most viral reads and more complete sequences within 15-h performance, indicating that it might be feasible for viral detection in multiple respiratory samples in clinical practice. | 2020-08-06 |
| 32754137 | We aimed to evaluate the clinical features and virological course of non-severe COVID-19 patients with or without symptoms who were admitted to a Chinese cabin hospital. […] Demographic, clinical, serial chest computed tomography (CT), and serial viral test data were compared between asymptomatic and symptomatic patients. […] The association between clinical features and symptomatic status or patient referral status was analyzed. | 2020-08-06 |
| 32754147 | While the SARS-CoV-2 pandemic is heavily hitting the world, it is of extreme importance that significant in vitro observations guide the quick set up of clinical trials. | 2020-08-06 |
| 32754163 | Here, we summarize the clinical and pathologic features of the cytokine storm in COVID-19. | 2020-08-06 |
| 32754205 | To evaluate and report the clinical characteristics and outcomes of SARS-CoV-2 infection in pregnant women and newborns in Latin America. […] Of 32% of symptomatic women, 89% (24) had mild symptoms and 3.5% (3) had severe respiratory symptoms. | 2020-08-06 |
| 32754206 | The basic clinical characteristics of the first 100 fatal cases from COVID-19 in Colombia were analyzed based on reports from the National Institute of Health (INS) since the beginning of the pandemic. […] Since the INS records do not include clinical variables of comorbidity in the total number of cases reported as positive, but only in patients with fatal outcome, comorbidities, age and sex available in the daily INS reports were reviewed. | 2020-08-06 |
| 32754234 | Methods An anonymous online survey of voluntary participation was applied, containing 30 questions regarding demographic aspects, availability of personal protective equipment (PPE), and impact on the routine of head and neck surgeons and otorhinolaryngologists, as well as clinical oncologists and radiation oncologists who work with head and neck diseases. […] Conclusion The study demonstrated a direct impact of the COVID-19 pandemic on the clinical practice of specialties related to the treatment of patients with diseases of the head and neck region already in the beginning of the illness management in Brazil. | 2020-08-06 |
| 32754235 | Introduction The COVID-19 pandemic has led to a reduction in surgical and clinical volume, which has altered the traditional training experience of the otolaryngology resident. […] Next, clinical duties were restructured to avoid unnecessary exposure of residents. […] Results To implement these key elements, our residency divided up our five hospitals into three functional groups based on geographical location and clinical volume. | 2020-08-06 |
| 32754248 | Objective The present review summarizes currently published evidence of Covid-19 epidemiology, clinical characteristics, treatment and prevention. […] Symptoms are varied, and not all patients develop all of them. | 2020-08-06 |
| 32754313 | However, how and to what extent the daily involvement of trainees in clinical and surgical activities was compromised by the COVID-19 pandemic is currently unknown. | 2020-08-06 |
| 32754345 | We were able to glean several clinical and human factor safety I-II components and LSTs such as overall lack of preparedness and awareness of donning/doffing of personal protective equipment (PPE), delayed response time, lack of experience in rapid sequence intubation, inability to timely and effectively assign roles, and lack of situational awareness. […] On the other hand, teams quickly recognized the patient’s clinical status and often communicated effectively. | 2020-08-06 |
| 32754375 | Implementing this tool with scores weighed on the number of lung pathological areas, a useful parameter for clinical monitoring could be available. | 2020-08-06 |
| 32754377 | Clinical manifestation of coronavirus disease (COVID-19) varies from asymptomatic to severe clinical forms that can result in acute respiratory distress syndrome or in multiple organ dysfunction syndromes. | 2020-08-06 |
| 32754388 | We have tabulated available data on various clinical trials testing various aspects of COVID-19 therapeutics. | 2020-08-06 |
| 32754408 | We have tabulated the available data on various clinical trials testing various aspects of COVID-19 vaccines. | 2020-08-06 |
| 32754409 | Although fever, cough, and shortness of breath have been recognized as hallmark symptoms, other lesser known complications continue to be described. | 2020-08-06 |
| 32754426 | COVID-19 predominantly presents with respiratory symptoms, but other presentations are reported, including cardiac manifestations and thromboembolism. | 2020-08-06 |
| 32754437 | Differential diagnosis can be challenging since influenza may present with similar symptoms. | 2020-08-06 |
| 32754447 | In this context, we have evaluated the psychological status of onco-hematological outpatients receiving infusion and not deferrable anti-neoplastic treatment for lymphoproliferative neoplasms, with the aim of both measuring the levels of post-traumatic symptoms, depression, and anxiety during the pandemic and also of investigating the perception of risk of potential nosocomial infection. | 2020-08-06 |
| 32754569 | Methods: A total of 37 overseas young and middle-aged people, who tested as SARS-CoV-2 positive upon their return to Shanghai, were enrolled for an analysis of their clinical symptoms, blood routine indexes, and lung CT images. […] Results: The clinical symptoms were characterized by fever (51.4%), dry cough (13.5%), expectoration (27.0%), hypodynamia (21.6%), pharyngalia (10.8%), pharynoxerosis (8.1%), rhinobyon (13.5%), rhinorrhea (8.1%), muscular soreness (16.2%), and diarrhea (2.7%). […] In 16.2% of cases, no symptoms were reported. | 2020-08-06 |
| 32754570 | The results from preliminary clinical trials have been mixed as far as improvement in the clinical condition and reduction in the duration of treatment are concerned. […] A number of new clinical trials are currently in progress to test the efficacy and safety of various approved drugs. | 2020-08-06 |
| 32754599 | Currently, a large-scale study on remdesivir (i.e., 200 mg on first day, then 100 mg once/day) is ongoing to evaluate its clinical efficacy to treat nCOVID-19. | 2020-08-06 |
| 32754600 | We obtained data on 29 cases of COVID-19 patients in Jinan, China, and reported the clinical data of asymptomatic patients confirmed with stool samples positive. […] We combined with epidemiological and clinical data of asymptomatic patients to analyze the possible routes of viral transmission and infection, including eyes-nose, hands-eyes, fecal-oral, and eyes-oral, et al., thus first presented the two-way transmission through eyes-oral. […] Through associating infection symptoms with the transmission routes of virus and the patient course of the disease, we expect to provide guidelines for clinical diagnosis and the basis for suppressing the spread of the virus and antiviral treatment. | 2020-08-06 |
| 32754627 | This study was to evaluate the effectiveness of questionnaire, symptoms-based screening, and polymerase chain reaction (PCR) screening of returnees from COVID-19-endemic areas on a chartered flight, to examine the proportion of infected persons and the proportion of asymptomatic persons among infected persons who returned from Wuhan. | 2020-08-06 |
| 32754730 | Pneumomediastinum is a rare clinical finding, but one which can be the source of significant concern for clinicians. | 2020-08-06 |
| 32754886 | Therefore, in this viewpoint, we present a brief review of several challenges we are frequently facing during this pandemic and a series of recommendations based on what we have implemented in our clinical practice at a university hospital currently mostly dedicated to COVID-19. | 2020-08-06 |
| 32754890 | This work demonstrates that both S312/S416 and old drugs (Leflunomide/Teriflunomide) with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide, no matter such viruses are mutated or not. | 2020-08-06 |
| 32754967 | Reverse transcription-polymerase chain reaction (RT-PCR) is an extremely common clinical method for detecting pathogens, particularly for emerging infectious diseases such as the new coronavirus disease (COVID-19). […] This study evaluates the characteristic performance of the analytical system in a clinical laboratory. […] A commercial SARS-CoV-2 RNA RT-PCR Kit used in a clinical laboratory is assessed based on ISO 15189 verification requirements. […] Compliance with international standards, such as ISO 15189, is valuable for clinical laboratories and for improving laboratory medicine quality and safety. […] This study aims to develop an improved SARS-CoV-2 verification framework compared with traditional molecular diagnostic methods, given the urgency of implementing new assays in clinical laboratories. | 2020-08-06 |
| 32754974 | A large amount of scientific studies and clinical trials are being carried out across the world to find a potential vaccine for this virus. […] The mechanisms of various drugs, their efficiency in various clinical trials and their side effects are also studied. | 2020-08-06 |
| 32754986 | We compared eating behaviours, and depressive and anxiety symptoms in two countries with different confinement strictness strategies and different levels of COVID-19 pandemic. […] Multivariable linear regression analyses were performed to identify country differences associated with eating behaviour, and symptoms of depression and anxiety. […] In Spain, 13.6%, and 12.3% of the survey respondents reported moderate to severe depressive and anxiety symptoms, respectively, whereas in Greece the respective values were 18.8 and 13.2%. […] After adjusting for several risk factors, a higher prevalence of anxiety symptoms was observed in Spain compared to Greece (p = .001), but no difference was seen for depressive symptoms. […] This study demonstrated high scores of inappropriate eating behaviours and a high frequency of depressive and anxiety symptoms in two Mediterranean countries during the COVID-19 outbreak. […] Our findings revealed that compared to Greek participants, Spanish participants, that faced more severe COVID-19 pandemic and stricter lockdown measures, were associated with lower restraint and external eating and increased anxiety symptoms, but not with depressive symptoms or emotional eating. | 2020-08-06 |
| 32755094 | In this review, we summarize the virus immune response steps, underlying the relevance of introducing the measurement of plasma cytokine levels and of circulating lymphocyte subsets in clinical practice for the follow-up of critically ill COVID-19 patients and support new therapy. | 2020-08-06 |
| 32755113 | In our article, we aimed to give some clinical suggestions related to sleep practices according to current data. | 2020-08-06 |
| 32755116 | The disease has variety of symptoms including fever, shortness of breath, cough, fatigue, loss of smell and taste and diarrhea. […] While the majority of cases have mild symptoms, some progress to viral pneumonia, multi-organ failure, or cytokine storm and mortality is mostly caused by hypoxemic respiratory failure. […] Such pathological studies have potential role on the understanding of clinical outcomes and in the development of novel targeted therapeutic approaches. | 2020-08-06 |
| 32755175 | All patients had positive results for the respective viruses from nucleic acid testing and had complete clinical data and CT images. […] CT findings and clinical data were evaluated. […] However, differentiating between COVID-19 pneumonia and influenza virus pneumonia in clinical practice remains difficult. | 2020-08-07 |
| 32755198 | The objective of our study was to investigate US findings in patients with COVID-19 and the relationship of the US findings with the duration of symptoms and disease severity. | 2020-08-07 |
| 32755212 | Imaging studies and medical records of sixteen patients (0-20 years) admitted with MIS-C were retrospectively reviewed. […] Other presenting signs and symptoms included: vomiting (12; 75%), abdominal pain (11; 69%), rash (10;62.5%), conjunctivitis (8;50%), diarrhea (7;44%), headache (6;37.5%), and sore throat (5;31%). | 2020-08-07 |
| 32755217 | To describe the imaging manifestations of COVID-19 associated coagulopathy in hospitalized patients, across anatomic sites and modalities, and to identify clinical variables associated with positive imaging findings. […] Patient demographics, hematologic values, cross-sectional imaging examinations, and clinical outcomes (death and intubation) were collected. […] Clinical variables poorly predict which patients have positive imaging, indicating a complementary role of imaging in detecting COVID-19 associated coagulopathy. | 2020-08-07 |
| 32755225 | An increase in frequency of acute ischemic strokes has been observed among patients presenting with acute neurologic symptoms during the coronavirus disease (COVID-19) pandemic. […] The purpose of this study was to investigate the association between COVID-19 and stroke subtypes in patients presenting with acute neurologic symptoms. […] Demographic data (age, sex, and race or ethnicity), COVID-19 status, stroke-related risk factors, and clinical and imaging findings pertaining to stroke were collected. […] CLINICAL IMPACT. […] Patients with COVID-19 presenting with acute neurologic symptoms warrant a lower threshold for suspicion of large vessel stroke, and prompt workup for large vessel stroke is recommended. | 2020-08-07 |
| 32755287 | To analysis 41 studies with 5064 patients were included.Patients who are elderly (SMD, 1.90; 95% CI, 1.01 to 2.8), male (OR, 1.71; 95% CI, 1.39 to 2.11) and have comorbidities or flu-like symptoms were significantly associated with the development to severe cases. | 2020-08-07 |
| 32755302 | The potentially fatal coronavirus disease (COVID-19), caused by air droplets and airborne as the main transmission modes, clearly induces a spectrum of respiratory clinical manifestations, but it also affects the immune, gastrointestinal, hematological, nervous, and renal systems. […] The main objective of the present review is to discuss the challenging issue relative to the clinical utility of plants-derived polyphenols in fighting viral infections. | 2020-08-07 |
| 32755347 | Anecdotal reports suggest fewer patients with stroke symptoms are presenting to hospitals during the coronavirus disease 2019 (COVID-19) pandemic. […] Hospital presentation for stroke-like symptoms decreased during the COVID-19 pandemic, without differences in stroke severity or early outcomes. | 2020-08-07 |
| 32755348 | We aim to study the clinical course of COVID-19 patients with preexisting stroke and to investigate death-related risk factors. […] Data on the demography, comorbidities, clinical manifestations, laboratory findings, treatments, complications, and outcomes (ie, discharged or death) of the participants were extracted from electronic medical records and compared between patients with and without preexisting stroke. | 2020-08-07 |
| 32755349 | Patients’ demographic, comorbid conditions, cardiovascular risk factors, COVID-19 disease status, and clinical presentation were extracted from the electronic medical record. | 2020-08-07 |
| 32755425 | In this review, we situate COVID-19 in its context as a transboundary viral disease, and provide a comprehensive discussion focused on the discovery, spread, virology, pathogenesis, and clinical features of this disease, its causative coronaviral pathogen, and approaches to combating the disease through immunotherapies and other treatments and vaccine development. | 2020-08-07 |
| 32755456 | We conducted this study to investigate the prevalence and distribution of cerebral microbleeds and leukoencephalopathy in hospitalized patients with coronavirus disease 2019 (COVID-19) and correlate with clinical, laboratory, and functional outcomes. […] We compared clinical, laboratory, and functional outcomes for these patients to patients who had a brain MRI that did not show these findings. | 2020-08-07 |
| 32755472 | Adaptive strategies should include good communication, a healthy work environment, flexible rules, dynamic infection control and adopting novel technology for clinical care and multidisciplinary work. | 2020-08-07 |
| 32755479 | To understand readiness measures taken by oncologists to protect patients and health care workers from the novel coronavirus (COVID-19) and how their clinical decision making was influenced by the pandemic. | 2020-08-07 |
| 32755524 | Viral RNA is usually detected two three days before the onset of symptoms and in the first week from upper respiratory tract samples. […] The clinical sensitivity of SARS-CoV-2 RNA tests has been reported around 55-75%. […] Anti-SARS-CoV-2 IgM, IgA and IgG antibodies have been shown to be detectable as early as 5th-14th days after the onset of symptoms and most of them become positive on the 21st day. […] It was shown that clinical sensitivity of the diagnostic approach increases when RNA and total antibody tests were integrated as co-tests, especially after the second week of the disease. | 2020-08-07 |
| 32755529 | Assay evaluation by assessment of 157 clinical specimens previously screened by E-gene RT-qPCR revealed assay sensitivity and specificity of 87 and 100%, respectively. […] Results were fast, with an average time-to-positive (Tp) for 93 clinical samples of 14 min (sd±7 min). […] A comparison of 20 clinical specimens between four laboratories showed excellent interlaboratory concordance; performing equally well on three different, commonly used thermocyclers, pointing to the robustness of the assay.Conclusion. | 2020-08-07 |
| 32755724 | According to clinical information, the incidence of vertical transmission of SARS-CoV-2 is limited to date. […] As the frequency and molecular mechanisms of intrauterine vertical transmission of SARS-CoV-2 have not been determined to date, intensive clinical examinations by repeated ultrasound and fetal heart rate monitoring are strongly recommended for pregnant women infected with COVID-19. | 2020-08-07 |
| 32755847 | PubMed, Cochrane Central Register of Clinical Trials were searched on April 16, 2020, to extract published articles that reported the outcomes of cancer in COVID-19 patients. […] The search terms were “coronavirus” and “clinical characteristics” with no language or time restrictions. | 2020-08-07 |
| 32755848 | Tuberculosis (TB) still continues to be endemic in various regions of the world, including in India and needs surveillance, clinical assessment, testing, contact tracing, confirmation of diagnosis with supervised or in-supervised treatment regimens for an effective eradication. | 2020-08-07 |
| 32755992 | Finally, we review the current clinical data associating vitamin D with SARS-CoV-2 infection, a putative clinical link that at this time must still be considered hypothetical. | 2020-08-07 |
| 32756065 | We explored the clinical management of inpatients with COVID-19 in Italy. […] A panel of experts was selected according to their clinical curricula and their responses were analyzed. | 2020-08-07 |
| 32756089 | The literature search will involve Cochran library, Web of science, PubMed, MEDLINE, Embase, China Biology Medicine Database, China National Knowledge Infrastructure Database, VIP, Wang Fang database, and China Clinical Trial Registration Center for articles and research published form December 2019. […] This systematic review protocol is designed to provide evidence regarding the effects and safety of Chinese traditional medicine injections on patients with COVID-19, such evidence may be useful and important for clinical treatment decisions. | 2020-08-07 |
| 32756114 | The Primary outcomes include: Clinical total effective rate, curative effect of TCM symptoms, pulmonary function and blood gas analysis. | 2020-08-07 |
| 32756125 | Related studies will be retrieved from Web of Science, Cochrane Library, PubMed, Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure, Chinese Scientific Journal Database, Wan fang Database, ClinicalTrials, WHO Trials, and Chinese Clinical Trial Registry. […] Clinical recovery time and effective rates will be assessed as the primary outcomes. […] Considering clinical heterogeneity, random effect model will be used for continuous outcomes. | 2020-08-07 |
| 32756132 | Evidence has been published on epidemiological and clinical characteristics of population groups considered at risk; however, information for the other population groups, especially for the child population, is needed. […] In this context, this protocol describes a systematic review that will aim to identify the evidence on control and prevention of COVID-19 transmission among children and adolescents, as well as to describe the epidemiological profile and clinical and immunological characteristics of COVID-19 in this population. […] The searches will be conducted in PubMed, Web of Science, ScienceDirect, EMBASE, and Scopus, seeking clinical trials. […] A high-quality synthesis of the available evidences on the epidemiological profile, the clinical and immunological characteristics involved in children, and adolescents diagnosed with COVID-19, as well as the participation of this population in the transmission dynamics of SARS-CoV-2 will be provided. | 2020-08-07 |
| 32756149 | These results indicated the clinical outcome and good tolerance of allogenic hUCMSCs transfer. | 2020-08-07 |
| 32756188 | The clinical course of all 4 patients diagnosed with COVID-19 and micturition syncope was favorable. | 2020-08-07 |
| 32756189 | Clinical data and data on changes in coagulation parameters were collected, verified, and characterized. […] These findings can serve as hypothesis generating and need further clinical trials to confirm. | 2020-08-07 |
| 32756270 | The aim of this study was to investigate the impact of COVID-19 pandemic on the clinical practices of spine surgeons within the Asia Pacific region. […] COVID-19 pandemic had changed spine surgeons’ clinical practices and their concerns toward personal and family risk of infection. […] First section includes surgeon’s demographics, background, type of clinical practice, and status of pandemic in their country. […] Third section includes changes of clinical practice during the pandemic and the last section was regarding their concern on COVID transmission. […] During the pandemic, 92.3% of the respondents felt their clinical practice was affected. […] COVID-19 pandemic has significantly affected the clinical and surgical practice of spine surgeons in the Asia Pacific region. […] Spine surgeons were moderately concerned of contracting COVID-19 during their clinical practice but were extremely concerned to transmit this disease to their family members. | 2020-08-07 |
| 32756271 | For each of the most frequent clinical scenarios, the authors reached a consensus on how should be timing and indications be optimized to reduce risk while maintaining the expected outcomes under the Covid-19 pandemics. […] Spine metastases can be found incidentally during follow-up or can clinically occur by increasing pain, pathologic fracture, and/or neurological symptoms. | 2020-08-07 |
| 32756323 | We conducted a search on the main medical databases for original articles, reviews, meta-analyses, randomized clinical trials and case series using the following keywords and acronyms and their associations: gut microbiota, microbiome, gut virome, immunity, gastrointestinal-associated lymphoid tissue (GALT), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steato-hepatitis (NASH), alcoholic liver disease, liver cirrhosis, hepatocellular carcinoma. | 2020-08-07 |
| 32756371 | The results of this study generated a hypothesis that a national BCG vaccination program seems to be associated with reduced mortality of COVID-19, although this needs to be further examined and proved by randomized clinical trials. | 2020-08-07 |
| 32756382 | People with existing non-communicable diseases (NCDs) are particularly vulnerable to health risks brought upon by emergencies and disasters, yet limited research has been conducted on disease management and the implications of Health-EDRM policies that address health vulnerabilities of people with NCDs during the COVID-19 pandemic. | 2020-08-07 |
| 32756475 | The questionnaire, developed and standardized previously in Italy, has four domains: (1) personal data; (2) symptoms/signs relative to COVID-19; (3) working conditions and PPE (personal protective equipment) adopted after the infection’s outbreak; (4) knowledge and self-perceived risk of infection. | 2020-08-07 |
| 32756480 | Finally, we outline clinical trials currently in progress to investigate the efficacy of potential therapies for COVID-19. | 2020-08-07 |
| 32756734 | More than one-third of COVID-19 patients present neurological symptoms ranging from anosmia to stroke and encephalopathy. […] Main neurological diagnoses included: encephalopathy (44.4%), stroke (16.7%), previous neurological diseases (9.0%), seizures (9.0%), neuromuscular disorders (5.6%), other acute brain lesions (3.4%), and other mild nonspecific symptoms (11.2%). […] First-line doctors should be able to recognize neurological symptoms; neurologists are important members of the medical team in COVID-19 hospital care. | 2020-08-07 |
| 32756872 | These were compared with 10 control patients with symptoms suspicious for SARS-CoV-2 but who tested negative. | 2020-08-07 |
| 32757186 | · A caution is recommended in the interpretation of clinical and laboratory data in neonates.. | 2020-08-07 |
| 32757246 | An association among the use of angiotensin converting enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) with the clinical outcomes of coronavirus disease 2019 (COVID-19) is unclear. […] Our results need to be interpreted with caution considering the potential for residual confounders, and more well-designed studies that control the clinical confounders are necessary to confirm our findings. | 2020-08-07 |
| 32757345 | However, many clinical trials and research works are undergoing to invent the effective vaccines or anti medications to lessen the dangerous consequences of COVID-19. | 2020-08-07 |
| 32757366 | Clinical observations so far indicate that the older population and immune compromised individuals, particularly in African American and Hispanic/Latino communities, are at much higher risk for infection with this novel coronavirus. […] This review will offer a conceptual basis for severe or controlled disease and address trepidations for pregnant women associated with COVID-19 pandemic, particularly in the comparative context of clinical consequences of other coronaviruses such as SARS and MERS. | 2020-08-07 |
| 32757404 | The aim was to identify specific clinical features of GBS associated with COVID-19. […] All the patients were symptomatic for COVID-19, with cough and fever as the most frequently reported symptoms. […] The interval between the onset of symptoms of COVID-19 and the first symptoms of GBS ranged from -8 to 24 days (mean 9 days; median 10 days). […] Most of the patients had a typical GBS clinical form predominantly with a demyelinating electrophysiological subtype. […] Published cases of GBS associated with COVID-19 report a sensorimotor, predominantly demyelinating GBS with a typical clinical presentation. […] Clinical features and disease course seem similar to those observed in GBS related to other etiologies. | 2020-08-07 |
| 32757419 | To document the prevalence of new headaches in patients with Covid-19 infection and the potential association with other neuro-sensorial symptoms (anosmia and ageusia). […] The persistence of these symptoms 1 month after recovery was also documented. […] These 2 symptoms persisted in 14.4% (20/139) and 11.5% (16/139) of Covid-19 patients 1 month after recovery. | 2020-08-07 |
| 32757420 | Additionally, the postulated protective effects of nicotine and nitric oxide, which may presumably reduce the risk of a “cytokine storm” in infected individuals, deserve assessment by controlled clinical trials. | 2020-08-07 |
| 32757428 | This is crucial to improving clinical quality and nursing safety and ensuring nurses’ physical and psychological health. | 2020-08-07 |
| 32757497 | We observed and analyzed the clinical efficacy of the most used hydroxychloroquine (HCQ) for 30 days. | 2020-08-07 |
| 32757499 | Depending on the epidemiological situation, each medical institution should systematically share the responsibility for patient screening, disposition and treatment according to clinical severity. | 2020-08-07 |
| 32757500 | This retrospective case series included 10 patients with a clinically and laboratory confirmed diagnosis of severe COVID-19 pneumonia who had received RDV for 5 days (n = 5) or 10 days (n = 5) in the Phase III clinical trial of RDV (GS-US-540-5773) conducted by Gilead Sciences. […] The clinical and laboratory data for these patients were extracted. […] All patients showed clinical and laboratory evidence of improvement. […] A well-designed randomized controlled clinical trial is now needed to confirm the efficacy of RDV in patients with COVID-19. | 2020-08-07 |
| 32757544 | Maintaining high personal hygiene by frequent handwashing and be vigilant of clinical signs are widely recommended to reduce the disease burden. […] Here, in this brief article, based on available clinical information, the author discusses why handwashing could be protective of COVID-19 infections. | 2020-08-07 |
| 32757708 | Despite a movement toward tele-based clinical services in other healthcare domains, implementation of these services within neuropsychology, particularly with pediatric populations, is limited. […] In this article, we provide case examples that illustrate the clinical implementation of this three-tiered telehealth service model of care for serving children during this uncertain time. […] The primary aim of this article is to provide examples outlining how clinical service decisions were made in the application of this three-tiered model for children with complex medical and neurodevelopmental histories. | 2020-08-08 |
| 32757745 | Our critical and comprehensive review presents emerging avenues of molecular diagnostics as well as therapeutics translated into clinical approaches. | 2020-08-08 |
| 32757751 | Demographic, clinical, laboratory, imaging, and outcome data were collected, and cases were compared with date-matched controls without COVID-19 from 1 year prior. | 2020-08-08 |
| 32757995 | Covid-19 antibody testing carried out 6 to 8 weeks after the onset of nasal symptoms showed positive immunoglobulin G antibodies in 3 of the 4 patients. | 2020-08-08 |
| 32758014 | Currently, with broader availability of polymerase chain reaction for disease diagnosis, CT is mainly used for the identification of complications and other defined clinical indications in hospitalized patients. […] Nonetheless, radiologists are interpreting lung imaging in unsuspected patients as well as in suspected patients with imaging obtained to rule out other relevant clinical indications. […] We briefly address the known pathological findings of the COVID-19 lung disease that may help better understand the imaging appearance, and we provide a demonstration of novel display methodologies and artificial intelligence applications serving to support clinical observations. | 2020-08-08 |
| 32758155 | To investigate the CT changes of different clinical types of COVID-19 pneumonia. […] We analyzed the clinical characteristics, CT characteristics and the pneumonia involvement of the patients between the moderate group and the severe and critical group, and the dynamic changes of severity with the CT follow-up time. | 2020-08-08 |
| 32758198 | None of patients had contact with other confirmed patients before the onset of symptoms, and only patient A and patient B made a short stop in Wuhan by train. | 2020-08-08 |
| 32758257 | The respiratory symptoms are similar to those accompanying other genetically related beta-coronaviruses (CoVs) such as severe acute respiratory syndrome CoV (SARS-CoV) and Middle East Respiratory Syndrome CoV (MERS-CoV). […] Hypoxemic respiratory symptoms can rapidly progress to Acute Respiratory Distress Syndrome (ARDS) and secondary hemophagocytic lymphohistiocytosis, leading to multi-organ system dysfunction syndrome. […] It also provides a theoretical integration of clinical and experimental data to elucidate the pathogenesis of these disorders. | 2020-08-08 |
| 32758273 | Focusing on epigenetic therapies reaching clinical trials, clinically approved epigenetic-targeted agents, and combination therapy of antivirals and epigenetic drugs is currently considered an effective and valuable approach for viral replication and inflammatory overdrive control. | 2020-08-08 |
| 32758298 | ◦ Confirmed SARS-CoV-2 infection with compatible symptoms AND a positive RT-PCR. […] • Exclusion criteria: ◦ Participant in a different COVID-19 study in which the study drug is under clinical development and hasn’t been previously authorized for commercialization. […] After 3 days of treatment, 3 intensive care physicians will evaluate the participant and decide whether or not to complete the treatment based on their clinical assessment: • If objective or subjective signs of improvement or no worsening of the general clinical condition, respiratory failure, inflammatory state or multi-organ failure are observed, the participant will continue the treatment until completion. […] • If an adverse effect or clinical impairment is observed that is objectively or subjectively attributable to the study drug the treatment will be stopped. […] EU Clinical Trials Register. | 2020-08-08 |
| 32758306 | We suggest the use of appropriate markers to assess the Se status of COVID-19 patients and possible supplementation may be beneficial in limiting the severity of symptoms, especially in countries where Se status is regarded as sub-optimal. | 2020-08-08 |
| 32758336 | Recently, Bacillus Calmette-Guérin (BCG) vaccine has shown successful results in reversing diabetes in both rats and clinical trials based on different mechanisms from aerobic glycolysis to beta cells regeneration. […] Some countries have started clinical trials that included a single dose BCG vaccine as prophylaxis from COVID-19 or an attempt to minimize its side effects. | 2020-08-08 |
| 32758342 | Gilead Science’s remdesivir has been introduced to China through special approval procedures, and was directly conducting the Phase III clinical trial. | 2020-08-08 |
| 32758438 | We aimed to investigate the prevalence of antibodies against SARS-CoV-2 in health-care workers and the proportion of seroconverted health-care workers with previous symptoms of COVID-19. […] Health-care workers working on dedicated COVID-19 wards (95 [7·19%] of 1321) had a significantly higher seroprevalence than other frontline health-care workers working in hospitals (696 [4·35%] of 15 983; RR 1·65 [1·34-2·03]; p<0·001). 622 [53·5%] of 1163 seropositive participants reported symptoms attributable to SARS-CoV-2. […] More than half of seropositive health-care workers reported symptoms attributable to COVID-19. | 2020-08-08 |
| 32758507 | The outcome was psychological distress, measured by five items on symptoms of anxiety, depression, loneliness, sleep difficulties, and hyperarousal. […] Fifteen percent of the sample experienced 2 psychological distress symptoms for at least 3 days over the past week; 13% had three or more symptoms. | 2020-08-08 |
| 32758625 | Various comorbidities and their associated symptoms accompany SARS-CoV-2 infection. | 2020-08-08 |
| 32758635 | The clinical spectrum of COVID-19 is broad and varies from mild to severe forms complicated by acute respiratory distress and death. […] Here we evaluate the level of evidence of available published interventional studies, with a focus on randomised controlled trials and the efficacy of therapies on clinical outcomes. […] Moreover, we present data on a large cohort of well-characterized patients hospitalized at a single University Hospital in Milano (Italy), correlating viral clearance with clinical and biochemical features of patients. | 2020-08-08 |
| 32758659 | We collected demographic, clinical, laboratory, treatment and complications data. […] The most common symptoms were a history of fever, cough, malaise and dyspnoea. | 2020-08-08 |
| 32758688 | We evaluated lymphocyte subsets and other clinical features of COVID-19 patients, and analyzed their potential impacts on COVID-19 outcomes. | 2020-08-08 |
| 32758689 | Number ChiCTR2000029496 at the Chinese Clinical Trial Registry (http://www.chictr.org.cn/). | 2020-08-08 |
| 32758693 | Demographics, CT features, nasopharyngeal swabs, baseline symptoms, and laboratory data were collected. […] Of 1407 HCWs, 235 had symptoms and 1172 were asymptomatic close contacts, of which, 107 were symptomatic cases and 84 were close contacts who had abnormal CT findings. | 2020-08-08 |
| 32758712 | Furthermore, compared with commercial real-time RT-PCR assay, it showed a kappa value of 0.959 (p < 0.001) from 150 clinical specimens. | 2020-08-08 |
| 32758794 | This research investigated the relationship between psychological resilience and mental health (depression, anxiety, somatization symptoms) among the general population in China. […] Psychological resilience, depression, anxiety, and somatization symptoms of 1770 Chinese citizens were investigated during the epidemic peak of coronavirus disease 2019 (COVID-19) (23rd February 2020 to 2nd March 2020). […] The prevalence of depression, anxiety, somatization symptoms was found to be 47.1%, 31.9%, 45.9%, respectively, among all participants. […] From them, 18.2% showed moderate to severe symptoms of depression, 8.8% showed moderate to severe symptoms of anxiety, and 16.6% showed moderate to severe symptoms of somatization. […] Analysis of the three-factor resilience structure showed that strength and tenacity were correlated with depression (standardized β = -0.256, P < 0.001; standardized β = -0.217, P < 0.001), anxiety (standardized β = -0.268, P < 0.001; standardized β = -0.147, P < 0.001), and somatization symptoms (standardized β = -0.236, P < 0.001; standardized β = -0.126, P < 0.01). | 2020-08-08 |
| 32758871 | SARS-CoV-2, the agent of COVID-19, shares a lineage with SARS-CoV-1, and a common fatal pulmonary profile but with striking differences in presentation, clinical course, and response to treatment. | 2020-08-08 |
| 32758873 | In the absence of animal models to test drugs, we need to find molecular explanations for any unforeseen peculiarities in clinical data, especially the recent reports describing an unexpected asthma paradox. | 2020-08-08 |
| 32758876 | The clinical manifestations of infected patients generally range from asymptomatic or mild to severe illness, or even death. […] One of the important clinical observations under conditions of critical illness show increased risk of developing disseminated intravascular coagulation. | 2020-08-08 |
| 32758877 | We hypothesize that COVID-19 patients are potentially vulnerable to a significant disease-drug interaction, and therefore, suitable dosing guidelines with therapeutic drug monitoring should be implemented to assure optimal clinical outcomes. | 2020-08-08 |
| 32758884 | This hypothesis suggests that a deficiency of nicotinamide adenine dinucleotide (NAD+) may be the primary factor related to the SARS-Cov-2 disease spectrum and the risk for mortality, as subclinical nutritional deficiencies may be unmasked by any significant increase in oxidative stress. | 2020-08-08 |
| 32758889 | Observational data thought to support IL-6 inhibition include elevated circulating IL-6 levels in COVID-19 patients and association between elevated IL-6 and poor clinical outcomes. […] Clinical experience with IL-6 receptor antagonists such as tocilizumab demonstrates increase in severe and opportunistic infections, raising concern about using tocilizumab and similar agents to treat COVID-19. | 2020-08-08 |
| 32758894 | Clinical and epidemiological studies are needed to support the hypothesis and plan the due prevention and awareness-raising campaigns. | 2020-08-08 |
| 32758903 | In the attempt to decipher the enigma of SARS-CoV-2 infectivology, the hypothesis should be tested whether the population of subjects who succumbed to Covid-19 may have developed a compromised immunity at sub-clinical levels and have become more susceptible to fatal consequences from SARS-Cov-2 infection due to statin therapy. | 2020-08-08 |
| 32758904 | Lung injury being the main clinical manifestation, it is likely to cause COPD (chronic obstructive pulmonary disease) and ARDS (acute respiratory distress syndrome). | 2020-08-08 |
| 32758929 | There has been growing evidence of gastrointestinal symptoms caused by SARS-CoV-2 infections and the presence of viral RNA not only in feces of infected individuals but also in wastewater. | 2020-08-08 |
| 32759006 | Other possible, but less likely mechanisms for the role of sandfly meals within a much shorter time frame may have led to, (i) previous exposure and infection of humans with the SARS-Cov-2 virus itself, or a closely related corona virus in the previous decades, or (ii) exposure of human populations to parts coronavirus protein namely either S or more likely N protein carried mechanically by arthropods, but without clinical disease causing direct immunity or (iii) by causing infection with other arthropod borne viruses which could carry bat DNA/RNA and have similar functional proteins resulting in an immediate cross-reactive immune response rather than by natural selection. | 2020-08-08 |
| 32759007 | Lymphopenia occurs early in the clinical course and is a predictor of disease severity and outcomes. | 2020-08-08 |
| 32759065 | However, providers have been slow to adopt telehealth into their clinical practice secondary to barriers such as cost and reimbursement (Kane and Gillis, 2018) [2]. | 2020-08-08 |
| 32759092 | None of the 2,122 patients admitted to COVID units experienced seizures among the early symptoms. | 2020-08-08 |
| 32759101 | The aim of this study was to evaluate the added value of information from clinical text in response to emergent diseases using natural language processing (NLP). | 2020-08-08 |
| 32759176 | Many clinical trials are currently underway to evaluate convalescent plasma for treatment of COVID-19, but the vast majority of plasma is currently administered as compassionate use of an experimental therapy through an expanded access program. […] Until these questions are answered, convalescent plasma should ideally be used in the context of well-designed clinical trials. | 2020-08-08 |
| 32759267 | Together, our data strongly suggest that ATV and ATV/RTV should be considered among the candidate repurposed drugs undergoing clinical trials in the fight against COVID-19. | 2020-08-08 |
| 32759372 | The majority of reports thus far have focused on the epidemiology, clinical factors, and acute care of these patients, with less attention given to the recovery phase and care of those patients requiring extended time on mechanical ventilation. | 2020-08-08 |
| 32759407 | The mean score of stress was raised with increasing duration of dealing with suspected/confirmed cases of COVID-19; r=0.202; P=0.004 and decreased with increasing age (r=-0.141; P=0.045), and clinical experience (r=-0.139, P=0.048). | 2020-08-08 |
| 32759457 | The main pillars are early upskilling of non-critical care staff, creation of safe, streamlined clinical pathways, adjustment of the physical layout of critical care units and comprehensive cross-town cooperation allowing to accommodate an increased number of patients, requiring intensive care. […] The model was well tested in clinical practice, enabling the hospital to increase the critical care footprint by more than 200% during the pandemic’s surge between March and May 2020. | 2020-08-08 |
| 32759504 | COVID-19 serum induced complement activation in vitro, consistent with high complement activity in clinical samples. | 2020-08-08 |
| 32759645 | In this article, attention is focused on the epidemiology, etiology and pathophysiological mechanisms of kidney damage, histopathology, clinical features in nephropathic patients (CKD, hemodialysis, peritoneal dialysis, AKI, transplantation) and prevention and containment strategies. | 2020-08-08 |
| 32759711 | It is an effective tool useful in research and in clinical practice. | 2020-08-08 |
| 32759719 | Besides advanced age and the presence of multiple comorbidities as major contributors to increased risk of severe disease and fatal outcome from Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19), there is now emerging evidence that overweight and obesity predispose to severe symptoms and negative prognosis. […] Furthermore, obesity may lead to other complications, such as renal failure, cardiovascular dysfunction, hypertension, and vascular damage, which in turn can further accelerate negative clinical outcomes from COVID-19. […] Health care providers should be aware that obesity predisposes to severe symptoms and negative prognosis in COVID-19 patients. | 2020-08-08 |
| 32759839 | While the influenza and SARS pandemics support this theory, there is less certainty regarding the clinical impact of SARS-CoV-2 in pregnancy. […] Whilst most viral vaccines are able to induce a seroprotective antibody response, in some high-risk individuals this may not correlate with clinical protection. […] In particular, we focus on the clinical implications of important respiratory viral infections such as influenza during pregnancy, and the pregnancy induced alterations in important leukocytes such as TFH, cTFH and B cells, which play an important role in generating long-lasting and high-affinity antibodies. | 2020-08-08 |
| 32759877 | The degrees of the depression, anxiety, insomnia, and distress symptoms of our participants were assessed using the Chinese versions of the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder-7 (GAD-7), the Insomnia Severity Index-7 (ISI-7), and the revised 7-item Impact of Event Scale (IES-7) scales, respectively, which found that the prevalence rates of depression, anxiety, insomnia, and distress caused by COVID-19 were 45.5%, 49.5%, 30.9%, and 68.1%, respectively. […] Participants working in Hubei province with heavy income losses, especially pregnant women, were found to have a high risk of developing unfavorable mental health symptoms and may need psychological support or interventions. | 2020-08-08 |
| 32759887 | This article reviews the pertinent clinical literature, technical guidance, and expert recommendations on use of ECMO in critically ill cases of COVID-19. | 2020-08-08 |
| 32759892 | The purpose of this article is to review the characteristics of SARS-CoV-2, the clinical-epidemiological aspects of COVID-19, and the implications anesthesiologists when performing aerosol-generating procedures. […] In general, the postponement of elective surgeries for no more than 6 to 8 weeks, depending on the clinical condition of the patients is recommended. | 2020-08-08 |
| 32759918 | Contact tracing provides an opportunity to identify contacts, inform them of quarantine recommendations, and monitor their symptoms to promptly identify secondary COVID-19 cases (7,8). […] Epidemiologic investigations were conducted for enrollees who reported symptoms or received a positive SARS-CoV-2 test result. | 2020-08-08 |
| 32760070 | In order to rapidly inform polices in the international response to the ongoing pandemic of coronavirus disease 19 (COVID-19), we summarize in this review current evidence on epidemiological and clinical features of the infection, transmission routes, problems of nucleic-acid testing, the epidemiological trend in China and impact of interventional measures, and some lessons learned. | 2020-08-08 |
| 32760107 | The clinical characteristics of COVID-19 have been reported; however, there is limited research investigating the clinical characteristics of COVID-19 in the Middle East. […] This study aims to investigate the clinical, radiological and therapeutic characteristics of patients diagnosed with COVID19 in Saudi Arabia. […] This case series provides clinical, radiological and therapeutic characteristics of hospitalised patients with confirmed COVID-19 in Saudi Arabia. | 2020-08-08 |
| 32760170 | Based on the available evidences, various clinical guidelines for management of COVID-19 have been formulated. | 2020-08-08 |
| 32760173 | There is an increased risk of morbidity if there is a need of intensive care unit postoperatively and a risk of high mortality if patient has symptoms of COVID-19. […] When an asymptomatic carrier develops symptoms of COVID after delivery or caesarean section, the morbidity increases. | 2020-08-08 |
| 32760206 | Seven out of nine patients revealed significant improvement in clinical parameters and chest CT images. […] This study provides experimental and clinical evidence that medium-to-low-dose glucocorticoids may play a protective role in the respiratory and digestive systems by activating ACE2 and suppressing cytokine storm. | 2020-08-08 |
| 32760350 | Aims: This study aimed to investigate the clinical courses and outcomes of diabetes mellitus patients with coronavirus disease 2019 (COVID-19) in Wuhan. […] We collected and analyzed their data, including demographic data, history of comorbidity, clinical symptoms, laboratory tests, chest computed tomography (CT) images, treatment options, and survival. […] Conclusions: Our study results suggested that diabetes had no effect on the prognosis of COVID-19 patients but had a negative association with their clinical courses. | 2020-08-08 |
| 32760407 | While most infected individuals only experience mild symptoms or may even be asymptomatic, some patients rapidly progress to severe acute respiratory failure with substantial mortality, making it imperative to develop an efficient treatment for severe SARS-CoV-2 pneumonia alongside supportive care. […] In this review, we aim to highlight the known mechanisms of immunomodulatory effects of high-dose IVIg therapy, the immunopathological hypothesis of viral pneumonia, and the clinical evidence of IVIg therapy in viral pneumonia. | 2020-08-08 |
| 32760409 | Ultimately, we hypothesize that the use of oral β-glucan in a prophylactic setting could be an effective way to boost immune responses and abrogate symptoms in COVID-19, though clinical trials are necessary to confirm the efficacy of this treatment and to further examine differential effects of β-glucan’s from various sources. | 2020-08-08 |
| 32760619 | Since the origin of the disease in Wuhan, China, understanding the pathophysiology, clinical presentation, screening guidelines, and management of the disease has been ever-evolving. […] This is a 20-year-old Hispanic female patient presenting with intractable vertigo, nausea, and vomiting but without any typical symptoms like fever, cough, or shortness of breath. […] There was minimal improvement in her vestibular symptoms with the recommended COVID-19 treatment as of March 2020 (hydroxychloroquine and azithromycin) and symptomatic management. […] Clinicians should consider COVID-19 in the differential diagnosis for patients presenting with similar symptoms, especially in areas of a high prevalence of this disease. […] These symptoms will just resolve with symptomatic management like any other case of vestibular neuritis without any further management that is specific for a COVID-19 infection. | 2020-08-08 |
| 32760740 | While the COVID-19 pandemic continues to spread rapidly, resulting in considerable morbidity and mortality worldwide, multiple efforts are being made by the international scientific community to understand the pathogenesis of the viral infection and its clinical outcome. […] An understanding of the mechanism underlying the effect of this infection on patients with cardiovascular disease is essential to manage and improve clinical strategies against the disease in that population. | 2020-08-08 |
| 32760752 | Despite the growing number of patients with COVID-19 infection, data on the clinical characteristics of pregnant patients are still limited. […] Demographic, clinical, radiological, laboratory, and treatment data were reviewed. […] Clinical characteristics of pregnant and nonpregnant patients were compared. […] Compared with nonpregnant patients (n = 80), pregnant patients (n = 31) were less likely to have dyspnea (16.1% vs 37.5%), asthenia (3.2% vs 33.8%), and ≥3 symptoms (22.6% vs 45.0%); had a significantly higher neutrophil count (5.2 vs 2.5 ×109/L) and a higher percentage of CD3+ cells (76.7% vs 73.7%) and CD8+ cells (32.3% vs 28.4%); and had a dramatically lower percentage of lymphocytes (18.2% vs 31.8%), a lower CD4+/CD8+ ratio (1.2 vs 1.4), and a lower level of IgG (9.8 vs 11.9 g/L). | 2020-08-08 |
| 32760887 | This clinical practice guideline includes pulmonary rehabilitation (PR) recommendations for adult COVID-19 patients and has been developed in the light of the guidelines on the diagnosis and treatment of COVID-19 provided by the World Health Organization and Republic of Turkey, Ministry of Health, recently published scientific literature, and PR recommendations for COVID-19 regarding basic principles of PR. | 2020-08-08 |
| 32761092 | A diagnostic comparison study was performed to evaluate the performance of the Cepheid Xpert Xpress SARS-CoV-2 assay compared to the Hologic Panther Fusion SARS-CoV-2 assay using clinical nasopharyngeal specimens. […] A total of 104 (54 positive and 50 negative) clinical nasopharyngeal samples were tested by both assays. | 2020-08-08 |
| 32761102 | To identify the clinical scenarios that pose communication challenges, understand patient reactions to these scenarios, and develop a communication guide with sample responses. […] Oncology-specific, COVID-19-related clinical scenarios were identified by the physicians, and potential reactions to these scenarios were gleaned from the patient responses to the survey. […] Oncology-specific, COVID-19-related clinical scenarios from physician interviews; responses to each scenario from patient surveys; and applicable communication principles from health communication expert literature review. | 2020-08-08 |
| 32761128 | However, little is known about the epidemiology and clinical characteristics of COVID-19 infants. […] We collected medical information of 46 confirmed patients (<1 year old) and retrospectively analyzed epidemiological history, clinical symptoms, and laboratory test results. | 2020-08-08 |
| 32761196 | Rapid discharge (length of stay = 13,8 ± 6,9) with remission of symptoms (BPRS = 27,5 ± 3,1) and satisfactory insight were possible after relatively low-dose antipsychotic treatment (Olanzapine-equivalents = 10,6 ± 5,4 mg). […] The youngest patient (Female, 23 years) also satisfied available criteria for Brief Limited Intermittent Psychotic Symptoms (BLIPS). | 2020-08-08 |
| 32761211 | We anticipate that our dataset can form the basis for future studies, supplemented with clinical and epidemiological data from the individuals affected with COVID-19 in Kerala. | 2020-08-08 |
| 32761260 | The study provides a novel base of evidence to identify asymptomatic patients and those without symptoms strongly associated with COVID-19 with incidental 18F-FDG PET/CT findings suspicious of SARS-CoV-2 infection during the initial stages of the pandemic. | 2020-08-08 |
| 32761294 | In this review, we described the COVID-19 vaccines that are currently tested in clinical trials and provided in-depth insight into the various types of vaccines, their compositions, advantages, and potential limitations. | 2020-08-08 |
| 32761396 | Majority of the patients (n = 36, 92.3%) with COVID-19 had ischemic stroke, 5.1% (n = 2) had hemorrhagic stroke, and 2.6% (n = 1) had cerebral venous thrombosis at the time of initial clinical presentation. | 2020-08-08 |
| 32761402 | Some patients with novel coronavirus disease 2019 (COVID-2019) present with abdominal symptoms. […] The goal of this study was to quantify the frequency of positive findings on abdominopelvic CT in COVID-positive patients, and to identify clinical factors associated with positive findings to assist with imaging triage. […] Clinical CT reports were reviewed for the provided indication and any positive abdominopelvic findings. | 2020-08-08 |
| 32761491 | The symptoms include fever, cough, dyspnea, early symptom of sputum, and acute respiratory distress syndrome (ARDS). […] Results indicated that MSC transplantation provides clinical data on the treatment of COVID-19 and may serve as an alternative method for treating COVID-19, particularly in patients with ARDS. | 2020-08-08 |
| 32761492 | We report the clinical and laboratory findings and successful management of seven patients with critical coronavirus disease 2019 (COVID-19) requiring mechanical ventilation (MV). […] The patients were diagnosed based on epidemiological history, clinical manifestations, and nucleic acid testing. | 2020-08-08 |
| 32761508 | This association was also observed in clusters of studies that defined severe manifestation of the disease by clinical parameters (RR 1.44, 95% CI 1.22-1.71; p < 0.0001), necessity of intensive care (RR 2.79, 95% CI 1.83-4.24; p < 0.0001) and in-hospital death (RR 2.18, 95% CI 1.75-2.7; p < 0.0001). […] A history of CVD might constitute an important risk factor of unfavorable clinical course of COVID-19 suggesting a need of tailored infection prevention and clinical management strategies for this population at risk. | 2020-08-08 |
| 32761535 | Further study is needed to evaluate safety and efficacy in clinical disease models. | 2020-08-08 |
| 32761898 | To provide a comprehensive and systematic analysis of demographic characteristics, clinical symptoms, laboratory findings, and imaging features of coronavirus disease 2019 (COVID-19) in pediatric patients. […] The typical clinical manifestations were fever 51% (95% CI: 45%-57%; I2 = 78.9%) and cough 41% (95% CI: 35%-47%, I2 = 81.0%). […] Pediatric patients with COVID-19 may experience milder illness with atypical clinical manifestations and rare lymphopenia. […] High incidence of critical illness and vomiting symptoms reward attention in children under 1 year old. | 2020-08-08 |
| 32761981 | All patients receiving reperfusion therapy for ischaemic stroke between 30 December 2019 and 3 May 2020 were recorded, and their baseline, clinical and radiological characteristics, extra- and intra-hospital times of action, Code Stroke activation pathway, COVID-19 status, reperfusion rate, and short-term outcome before and after the setting of the emergency state were analysed. | 2020-08-08 |
| 32761999 | The delay between the first respiratory symptoms of COVID-19 and stroke was 11.5 days. | 2020-08-08 |
| 32762043 | Because of that, our clinical practice was changed so as to minimize risk of SARS-CoV-2 infection while continuing haematological treatment. | 2020-08-08 |
| 32762081 | This is of major potential clinical relevance, as currently available anti-complement therapies that are highly effective in protecting against thrombosis in aHUS, could be efficacious in COVID-19. […] Based on current knowledge of complement, coagulation and the virus, we suggest lines of study to identify novel therapeutic targets and the rationale for clinical trials with currently available anti-complement agents for COVID-19. | 2020-08-08 |
| 32762083 | While three of the patients (age range 63-90) exhibited merely mild to moderate hypoxia-associated changes, one 38-year-old subject with obesity, diabetes (type 2), Parkinson’s disease and a very severe clinical course was found to have severe ischemic injury, abundant microhemorrhages and enlarged perivascular spaces most pronounced in the white matter and deep gray matter. | 2020-08-08 |
| 32762106 | Demographic, clinical, laboratory, and treatment data were obtained from the registry and compared between hospitalized and nonhospitalized patients as well as those with critical illness. | 2020-08-08 |
| 32762140 | This increase was observed in patients with mild symptoms and not further augmented in patients with severe symptoms. | 2020-08-08 |
| 32762158 | In addition to common clinical features, patients with coronavirus disease 2019 (COVID-19) have varying degree of coagulation dysfunction with the risk of thrombosis and/or bleeding. […] This article reviews the research progress of COVID-19 related coagulation dysfunction, to provide reference for clinical research and management. | 2020-08-08 |
| 32762171 | The main related the pathways of renin-angiotensin system, protein digestion and absorption pathway, and the reactome pathways of metabolism of angiotensinogen to angiotensins, GPCR ligand binding, are related to typical symptoms of coronavirus disease 2019 induced by SARS-CoV-2. […] The similarity of S protein of SARS-CoV-2 and SARS-CoV determines that they have similar infection patterns and clinical manifestations. | 2020-08-08 |
| 32762214 | The advantages and limitations of several methods was compared, which can provide a basis for the selection of 2019 novel coronavirus clinical diagnosis methods. | 2020-08-08 |
| 32762250 | The general and clinical characteristics of selected respiratory viruses along with available viral treatments and vaccines are reviewed. […] The dire need for these scientific discoveries is highlighted by the recent COVID-19 pandemic, which has prompted investigators worldwide to conduct clinical trials at an accelerated timeline in an effort to reduce the morbidity and mortality associated with SARS-CoV-2 infection. | 2020-08-09 |
| 32762270 | Evidence suggests that telemedicine in orthopaedics can be safe, cost effective, valid in clinical assessment and with high patient/clinician satisfaction. | 2020-08-09 |
| 32762282 | US Centers for Disease Control and Prevention (CDC) recently included ‘sudden loss of taste (dysgeusia/ageusia) and smell (anosmia/hyposmia)’ as symptoms of COVID-19. […] If indeed these symptoms are reliable and specific forerunner symptoms of COVID-19, then it may facilitate detection and containment of the disease. […] Hence, we systematically evaluated the contemporary evidence on dysgeusia and anosmia as trigger prodromal symptoms, and their prevalence in COVID-19 patients. […] In total, anosmia and dysgeusia symptoms were present in 74.9% and 81.3% ambulatory as well as hospitalized, mild-to-severe cases of COVID-19 patients, respectively. […] The European, US and Iran data indicate olfactory and gustatory symptoms appear prior to general COVID-19 symptoms in 64.5% and 54.0% of the patients, respectively. […] Critical analysis of such macro-data, as and when available, is essential to evaluate their utility as harbingers of COVID-19 onset, and to establish clinical practice guidelines both in dentistry and medicine. | 2020-08-09 |
| 32762291 | The present study is the first to examine which fear factors uniquely predict clinical levels of depressive symptoms and generalized anxiety. | 2020-08-09 |
| 32762354 | COVID-19 decreased overall clinical productivity, revenue, and income. | 2020-08-09 |
| 32762443 | These conditions might lead to systemic thrombotic events that could impair the clinical staff’s efforts to avoid fatal outcomes. | 2020-08-09 |
| 32762477 | Products from this project included a standard operating procedure for safe use of tablet computers for inpatient palliative care consultations and family visitations; tablet procurement with installation of video telehealth software; and training and education for clinical staff and other stakeholders. […] Successful use of video telehealth for palliative care involved overcoming inertia to the development of telehealth infrastructure and learning clinical video telehealth skills; and engaging front-line care staff and family members who were open to a trial of telehealth for communication. | 2020-08-09 |
| 32762494 | The patient was examined 5 days before the onset of coronavirus disease 2019 (COVID-19) symptoms and was admitted to the hospital 2 days after. | 2020-08-09 |
| 32762510 | Depression and anxiety symptoms were lower in athletes compared to non-athletes (p < 0.05). […] Depression, anxiety and stress symptoms were similar in team athletes and individual athletes (p = 0.232, p = 0.444, p = 0.116; respectively). […] The post-traumatic stress symptoms were lower in male team athletes than female team athletes (p = 0.020) and non-athletes (p < 0.001). […] Depression, anxiety and stress symptoms were found to be similar in men and women (p > 0.05). […] There was a negative correlation between physical activity level and mental health symptoms (p < 0.05). | 2020-08-09 |
| 32762665 | Demographic, clinical, laboratory, and radiological data were collected at hospital admission and data on disease severity were collected during follow-up. | 2020-08-09 |
| 32762696 | However, few studies have focused on the epidemiological and clinical characteristics of pediatric COVID-19. […] This study conducted a retrospective review of the epidemiological and clinical features of COVID-19 in children. […] A majority of pediatric COVID-19 cases showed mild to moderate clinical features, and only a few developed severe or critical diseases (0.6% and 0.3%, respectively). […] Fever (77.9%) and cough (32.4%) were the predominant presenting symptoms of pediatric COVID-19. […] Compared to adults, COVID-19 in children has distinct features of epidemiology and clinical manifestations. […] Chinese Clinical Trial Registry (chictr.org.cn) identifier: ChiCTR2000030464. | 2020-08-09 |
| 32762723 | We describe the clinical presentation, diagnosis, treatment, and outcome. | 2020-08-09 |
| 32762737 | Chemosensitive functions were assessed with psychophysical tests within 4 days of clinical onset, at 10 and 20 days. | 2020-08-09 |
| 32762834 | Only limited evidence has been available to date on the accuracy of systematic low-dose chest computed tomography (LDCT) use in the diagnosis of COVID-19 in patients with non-specific clinical symptoms. […] In patients with symptoms compatible with COVID-19, LDCT can esablish the diagnosis of COVID-19 with comparable sensitivity to RT-PCR testing. […] In addition, it offers a high specificity for distinguishing COVID-19 from other diseases associated with the same or similar clinical symptoms. | 2020-08-09 |
| 32762885 | Although the predominant clinical feature of coronavirus disease-2019 (COVID-19) is an acute respiratory syndrome of varying severity, ranging from mild symptomatic interstitial pneumonia to acute respiratory distress syndrome, the cardiovascular system can be involved in several ways. […] Multiple pathways have been suggested to explain this finding and the related clinical scenarios, encompassing local and systemic inflammatory responses and oxygen supply-demand imbalance. […] From a clinical point of view, cardiac involvement during COVID-19 may present a wide spectrum of severity, ranging from subclinical myocardial injury to well-defined clinical entities (myocarditis, myocardial infarction, pulmonary embolism, and heart failure), whose incidence and prognostic implications are currently largely unknown because of a significant lack of imaging data. […] Integrated heart and lung multimodality imaging plays a central role in different clinical settings and is essential in the diagnosis, risk stratification, and management of patients with COVID-19. | 2020-08-09 |
| 32762922 | To create a registry of patients with COVID-19 hospitalized in Spain, in order to improve our knowledge of the clinical, diagnostic, therapeutic, and prognostic aspects of this disease. […] Epidemiological and clinical data, additional tests at admission and at seven days, treatments administered, and progress at 30 days of hospitalization were collected from electronic medical records. […] The most frequent symptoms were fever (84.2%) and cough (73.5%). […] The SEMI-COVID-19 Network provides data on the clinical characteristics of patients with COVID-19 hospitalized in Spain. | 2020-08-09 |
| 32763024 | We describe the diagnosis, clinical course and management of the patient and their family with regards to clinical, social and infection control measures around delivery. […] This case highlights the importance of the cooperation of multidisciplinary teams to achieve good clinical outcomes in complex patients with COVID-19. | 2020-08-09 |
| 32763110 | The goal was to assess individuals’ weight changes and their connections with depressive symptoms, optimism and physical activity. […] Depressive symptoms were linked to larger weight changes. | 2020-08-09 |
| 32763118 | Twenty-six patients recovered from COVID-19 who reported cardiac symptoms and underwent CMR examinations were retrospectively included. […] Attention should be paid to the possible myocardial involvement in patients recovered from COVID-19 with cardiac symptoms. | 2020-08-09 |
| 32763128 | The clinical presentation and viral pathogenesis of the coronavirus disease named COVID-19 indicated that the virus is transmitted from person to person through infected droplets entering the respiratory mucosa. […] Clinical manifestations of the viral infection have mentioned the presence of some ocular findings such as conjunctival congestion, conjunctivitis and even corneal injury associated with the classical COVID-19 infection. | 2020-08-09 |
| 32763357 | The primary end point was to assess the impact of hydroxychloroquine with or without azithromycin, on outcome, length of hospitalization, and time to clinical improvement. […] All analyses accounted for age, gender, race, severity on admission, days from symptoms onset and chronic comorbidities. 36 patients received hydroxychloroquine and were age- and sex-matched to 72 patients with COVID-19 who received supportive care. […] Compared to supportive care, the use of HCQ did not shorten the time to clinical improvement (+0.23 days; 95% CI: -1.8-2.3 days) nor did it shorten the duration of hospital stay (+0.91 days; 95% CI: -1.1-2.9 days). | 2020-08-09 |
| 32763444 | Based on these clinical and neurophysiological findings, a diagnosis of critical illness myopathy was made according to the current diagnostic criteria. | 2020-08-09 |
| 32763457 | Primary study end point was defined as primary clinical success. […] Overall, at a median follow-up of 23 ± 13 days, primary clinical success was 87.1% and secondary clinical success was 95.9%. | 2020-08-09 |
| 32763477 | Thus, we performed a rapid review and meta-analysis of posttraumatic stress and general psychological stress symptoms during COVID-19. […] Random effects meta-analyses indicated that the pooled prevalence of posttraumatic stress symptoms and psychological stress in the general population was 23.88% and 24.84%, respectively. […] In both meta-analyses, the prevalence of stress symptoms was higher in unpublished compared to peer-reviewed studies. | 2020-08-09 |
| 32763496 | Thus, our aim was to gather all available information regarding comorbidities, clinical signs and symptoms, outcomes, laboratory findings, imaging features, and treatments in patients with coronavirus disease 2019 (COVID-19). […] The primary outcome was the risk ratio of comorbidities, clinical signs and symptoms, laboratory findings, imaging features, treatments, outcomes, and complications associated with COVID-19 morbidity and mortality. | 2020-08-09 |
| 32763536 | Three fourth of patients were not worried about getting COVID-19 and lacks adequate knowledge to identify symptoms. […] Thirty percent showed features of relapse of symptoms during this lockdown period. | 2020-08-09 |
| 32763640 | We compared the efficacy of the ICU diary, written by family and healthcare workers during the patient’s intensive care course, versus education alone in reducing acute PTSD symptoms after discharge. […] The control group had a significantly greater decrease in PTSD, hyperarousal, and depression symptoms at week 4 compared to the intervention group. […] Both study groups exhibited clinically significant PTSD symptoms at all timepoints after ICU discharge. […] Follow-up phone interviews with patients revealed that while many were interested in getting follow-up for their symptoms, there were many barriers to accessing appropriate therapy and clinical attention. […] Results from psychological screening tools demonstrate no benefit of ICU diaries versus bedside education-alone in reducing PTSD symptoms related to the intensive care stay. […] However, our study finds an important gap in clinical practice - patients at high risk for PICS are infrequently connected to appropriate follow-up care. | 2020-08-09 |
| 32763657 | The novel coronavirus (SARS-CoV-2) is primarily a respiratory pathogen and its clinical manifestations are dominated by respiratory symptoms, the most severe of which is acute respiratory distress syndrome (ARDS). | 2020-08-09 |
| 32763660 | The anti-inflammatory and proteinase-activated receptor axis properties of ABS with a considerable amount of oestrogenic hormone presence highlight this unique topical hemostatic drug regarding the clinical re-positioning for COVID-19-associated mucositis. | 2020-08-09 |
| 32763728 | Two groups were compared in terms of demographic features, clinical characteristics and SARS-CoV-2 positivity. […] Although, one case in the high-risk pregnancy group had developed symptoms highly suspicious for COVID-19, two repeated RT-PCR tests were negative. | 2020-08-09 |
| 32763754 | These findings may support the planning of preventive interventions and could contribute to improvements in the assessment and management of patient risk factors in clinical practice, leading to the mitigation of severe outcomes in patients with COVID-19 infection. | 2020-08-09 |
| 32763809 | Here, we evaluate the clinical performance of five automated immunoassays on a set of clinical samples. […] Positivity of assays (onset of symptoms > 10 days) ranged between 68.4 % and 81.6 % (Diasorin 68.4 %, Euroimmun 70.3 %, Siemens 73.7 %, Roche 79.0 % and Wantai 81.6 %). […] All assays showed good clinical performance. […] Our data confirm that orthogonal test strategies as recommended by the CDC can enhance clinical specificity. | 2020-08-09 |
| 32763818 | Only drugs that are already registered or close to registration, and therefore have passed lengthy safety assessments, have a chance to be tested in clinical trials and reach patients quickly enough to help in the current disease outbreak. […] Presented pros and cons, knowledge gaps and methods to identify lysosomotropic antivirals, can help in the evaluation of many drugs currently in clinical trials considered for repurposing to target COVID-19, as well as open doors to finding more potent and safer alternatives. | 2020-08-09 |
| 32763889 | The implementation of digital health tools has suffered from 2 limitations: (1) the interventions commonly ignore the “law of amplification” that states that technology is most likely to succeed when it seeks to augment and not alter human behavior; and (2) end-user needs and clinical gaps are often poorly understood while designing solutions, contributing to a substantial decrease in usage, referred to as the “law of attrition” in eHealth. | 2020-08-09 |
| 32763891 | This study describes the mental health and well-being of workers both with and without clinical exposure to patients with coronavirus disease (COVID-19). […] We examined associations between these outcomes and factors including work in high-risk clinical settings and family/home stressors. […] Overall, 34% of faculty and 14% of staff (n=915) were providing clinical care, while 61% of faculty and 77% of staff were working from home. […] Among all workers, anxiety (prevalence ratio 1.37, 95% CI 1.09-1.73), depression (prevalence ratio 1.28, 95% CI 1.03-1.59), and high work exhaustion (prevalence ratio 1.24, 95% CI 1.13-1.36) were independently associated with community or clinical exposure to COVID-19. […] Among the subset of clinicians, caring for patients with COVID-19 and working in high-risk clinical settings were additional risk factors. […] Our findings suggest that the pandemic has had negative effects on the mental health and well-being of both clinical and nonclinical employees. | 2020-08-09 |
| 32764107 | Fire department personnel were emailed a survey link assessing COVID-19 symptoms and work exposures the day prior to the scheduled drive-through antibody testing at a designated fire station. | 2020-08-09 |
| 32764118 | Since stimulation of the Ang-(1-7)/Mas axis protects the endothelial barrier in acute lung injury (ALI), we hypothesised that increased Ang-(1-7)/Mas signalling may protect females over males in ALI/ARDS.Clinical data were collected from Charité inpatients. | 2020-08-09 |
| 32764120 | This review will discuss the current structural and functional imaging techniques used for the diagnosis of bacterial infection and their roles in different clinical scenarios. | 2020-08-09 |
| 32764134 | The median delay from onset of symptoms to hospitalisation was 8 (7-10) days. | 2020-08-09 |
| 32764155 | The outbreak of COVID-19 has stalled both the basic, clinical and non-COVID medical research. | 2020-08-09 |
| 32764200 | We used multiple linear regression and predictive models to assess the correlations between antibody responses and demographic and clinical characteristics. | 2020-08-09 |
| 32764201 | Data about demographics, symptoms, laboratory values, and clinical outcomes were collected for 1,003 consecutive patients testing positive for COVID-19. […] Logistic regression was used to evaluate the association of lipase levels with primary clinical outcomes (intensive care unit admission and intubation) adjusted for age, sex, body mass index, history of diabetes, and hypertension. | 2020-08-09 |
| 32764275 | Therapeutic agents currently under investigation are antiviral drugs, vaccines, and other adjuvants that could relieve symptoms or improve the healing process. […] In this review, twelve therapeutic agents that could play a role in prophylaxis or improvement of the COVID-19-associated symptoms (as add-on substances) are discussed. […] This review gives the scientific background on the hypothesis that these therapeutic agents can act in synergy in the prevention and improvement of COVID-19-associated symptoms. | 2020-08-09 |
| 32764417 | Based on the current published evidence, herein we summarize the origin, genetics, epidemiology, clinical manifestations, preventions, diagnosis and up to date treatments of SARS-CoV-2 infections in comparison with those caused by SARS-CoV and MERS-CoV. | 2020-08-09 |
| 32764454 | In general, SARS-CoV-2 causes symptoms ranging from the common cold to severe conditions accompanied by lung injury, acute respiratory distress syndrome in addition to other organs’ destruction. | 2020-08-09 |
| 32764509 | Medical professionals more often presented with relevant psychopathological symptoms (GHQ-28 (General Health Questionnaire-28) total score >24) than the non-medical group (60.8% vs. […] 48.0%, respectively) such as anxiety, insomnia and somatic symptoms even after adjustment for potential confounding factors. […] Somatic and anxiety symptoms as well as insomnia are more prevalent among medical staff than workers in other professions. | 2020-08-09 |
| 32764825 | Participants from cities exhibited these symptoms more than participants from rural areas, however rural participants experienced more sadness than urban participants. | 2020-08-09 |
| 32764857 | Spinal surgery during the COVID-19 pandemic is an intricate challenging decision-making process, involving clinical, sociologic and economic factors. | 2020-08-09 |
| 32764893 | We created a self-administered electronic survey that was piloted and evaluated for its clinical relevance. | 2020-08-09 |
| 32764907 | However, for those already taking these medications, both the European Society of Cardiology and the American College of Cardiology recommend continuing the treatment, because at present, there is no clear clinical or scientific evidence to justify the discontinuation of ACE-I or ARBs. […] Individualized treatment decisions should be based on the clinical condition and co-morbidities of each patient. | 2020-08-09 |
| 32765012 | Among the studied demographic, clinical, hematological, biochemical, and imaging data, dyspnea, diabetes mellitus, lymphopenia, raised CRP, ESR, ferritin, ALT, AST, low albumin, and presence of CT chest findings could be considered as predictors for COVID-19 severity using binary logistic regression analysis. | 2020-08-09 |
| 32765013 | The 21st century has seen the worldwide spread of three recognized coronaviruses (CoVs) which can cause pneumonia and severe acute respiratory symptoms (SARSs), SARS, MERS, and recently SARS-CoV-2. | 2020-08-09 |
| 32765133 | COVID-19 is a highly infectious and contagious disease which has presented the Iranian healthcare system with a variety of clinical challenges. […] There is a lack of research on clinical challenges in health crises especially those caused by emerging diseases, hence a need for more exploration of these clinical challenges and dilemmas. | 2020-08-09 |
| 32765138 | Epidemiological, demographic, clinical, laboratory, radiological, treatment data, and clinical outcomes were collected. | 2020-08-09 |
| 32765185 | Participants were asked whether they had experienced fever or other cold symptoms between February 17, 2020 and the date of the survey. […] Of the survey participants, 82 had experienced fever or other cold symptoms (6.7%). […] The prevalence of strict self-isolation among participants who experienced cold-like symptoms during the COVID-19 outbreak was extremely low, and 62.2% of these participants went to work within 7 days after symptom onset. | 2020-08-09 |
| 32765274 | We conducted a clinical trial to compare the effectiveness of three antiviral treatment regimens in patients with mild to moderate COVID-19. […] This was a single-center, randomized, open-labeled, prospective clinical trial. […] Baseline clinical and laboratory characteristics of patients were comparable among the three groups. | 2020-08-09 |
| 32765283 | This retrospective, single-center study included 728 adult COVID-19 patients and used data extracted from electronic medical records for analyses. | 2020-08-09 |
| 32765321 | It was hypothesized that perceived high risk of contracting COVID-19 (close contact with cases, inadequate provision of personal protective equipment, insufficient infection control training, and presence of symptoms) would be significant predictors of depression. | 2020-08-09 |
| 32765592 | On the other hand, from over representation analysis, our study revealed that although both SARS-CoV and SARS-CoV-2 viral miRNAs could target broad immune-signaling pathways; only some of the SARS-CoV-2 miRNAs are found to uniquely target some immune-signaling pathways, such as autophagy, IFN-I signaling, etc., which might suggest their immune-escape mechanisms for prolonged latency inside some hosts without any symptoms of COVID-19. | 2020-08-09 |
| 32765712 | The clinical picture of this infection is in a dynamic process of discovery, and more symptoms emerge as the clinicians observe and diagnose manifestations that affect multiple organs. […] Anosmia (loss of smell), and ageusia (loss of taste) become more frequently cited as independent symptoms or in association with the most common manifestations of the disease, such as fever, cough and dyspnea. […] Therefore, it is important to include frequent symptoms in the anamnesis and questionnaires to select those patients who might benefit from testing, isolation, and treatment. […] It also aims to describe manifestations of these, particularly in the clinical picture of all symptomatic patients. | 2020-08-09 |
| 32765748 | While facing this fatal disease, research and clinical observations need to be carried out in order to evaluate the long-term effects of the COVID-19 acute respiratory distress syndrome (ARDS). […] Potent clinical and laboratory biomarkers should be studied to be able to predict the subgroup of patients that are going to deteriorate or develop lung fibrosis. | 2020-08-09 |
| 32765844 | It is aimed at using docking studies to screen molecules for clinical application and investigating their efficacy in inhibiting SARS-CoV-2-S. | 2020-08-09 |
| 32765937 | Therefore, utilizing a geroscience approach, targeting aging processes to prevent multimorbidity, via initiating broad clinical trials of potential geroprotective therapies, is recommended. | 2020-08-09 |
| 32765943 | This study aims to describe clinical characteristics and determine risk factors for intensive care unit (ICU) admission of COVID-19 patients with CVD. | 2020-08-09 |
| 32765952 | Single-arm meta-analysis was performed to summarize the clinical features of confirmed COVID-19 patients. | 2020-08-09 |
| 32765959 | Analysis of clinical features in light of most recently published data allows for improved understanding, and better clinical judgement. […] Variety in symptoms was observed, with fever, cough, dyspnea, fatigue, or sputum production being the most common. | 2020-08-09 |
| 32765962 | We used International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10) codes in the categories Z55-Z65 to identify SDOH that potentially modulate MCH disparities. | 2020-08-09 |
| 32765991 | In our review, we determined that the key steps taken by Nepal included border control to prevent the importation of cases, strict quarantine in facilities for anyone entering the country, early case detection, and isolation of all infected cases irrespective of symptoms. | 2020-08-09 |
| 32766088 | A detailed analysis of the clinical picture and existing diagnostic tests for COVID-19 was performed to achieve the desired objectives. | 2020-08-09 |
| 32766099 | The cardiologists are called as consultants for the cardiovascular pathologies and echocardiography is a fundamental examination in many clinical situations, but not without risks for health staff. | 2020-08-09 |
| 32766112 | This map organizes information about symptoms management (especially on dimensions related to mental health and mild viral respiratory infections, as well as immune system strengthening and antiviral activity). […] A search was performed in the Traditional, Complementary and Integrative Medicine Virtual Health Library and PubMed, using the MeSH and DeCS terms for respiratory viral diseases associated with epidemics, COVID-19 symptoms, relevant mental health topics, pharmacological and non-pharmacological interventions related to TCIM. […] For the map, 126 systematic reviews and controlled clinical studies were characterized, distributed in a matrix with 62 interventions (18 phytotherapy, 9 mind-body therapies, 11 traditional Chinese medicine, 7 homeopathic and anthroposophic dynamized medicines and 17 supplements), and 67 outcomes (14 immunological response, 23 mental health, 25 complementary clinical management of the infection and 5 other). | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766113 | The present online discussion suggested possible directions of clinical research in KM for the post-COVID-19 era. | 2020-08-09 |
| 32766162 | Our analysis is based on the concerns of our patients during our daily clinical interactions in both outpatient and inpatient settings. […] We describe these psychological threats, provide clinical context for them, and offer practical suggestions for managing them, for the benefit of patients, their caregivers, and clinicians. […] Our hope is that, by sharing our clinical experience, we can help other oncologists increase their awareness of the psychological impact of the pandemic on cancer patients and implement solutions. | 2020-08-09 |
| 32766251 | In fact, promising clinical studies using MSC to treat COVID-19, are currently underway. | 2020-08-09 |
| 32766256 | Although many clinical trials are testing the efficacy of targeting inflammatory cytokines/chemokines in COVID-19 patients, the critical inflammatory mediator initiating COVID-19 patient death is undefined. […] Here we suggest that the immunopathological pathway leading to COVID-19 mortality can be divided into three stages with distinct clinical features that can be used to guide therapeutic strategies. […] Our interpretation of the recently published clinical trials from COVID-19 patients suggests that the clinical efficacy in preventing COVID-19 mortality using IL-1 blockade is subjected to notable caveats, while that for IL-6 blockade is suboptimal. | 2020-08-09 |
| 32766266 | Polyclonal preparation of IgM as an adjuvant therapy has been reported as a relevant immunomodulant therapy in several infectious diseases, exhibiting, in most cases, improvement of the clinical course. […] We therefore treated a selected patient with interstitial multifocal pneumonia, positive to COVID-19, with polyclonal preparation of immunoglobulins as an adjuvant therapy, obtaining in few days clinical remission and improvements in radiological findings. […] Based on this case report, we suggest that clinical trials are conducted to test the efficacy and safety of polyclonal immunoglobulins for adjunctive therapy of COVID-19. | 2020-08-09 |
| 32766268 | This study aimed to identify early indicators of disease progression to provide a basis for improved prognostic prediction and disease management. […] Methods: We examined 53 recovered adult COVID-19 patients who were treated at Shanghai Public Health Clinical Center between January 20, 2020, and February 20, 2020. | 2020-08-09 |
| 32766285 | Conclusions: Among participants tested for COVID-19 with presumed moderate to severe symptoms in a hospital setting, BAME ethnicity, male sex, and higher BMI are associated with a positive result. | 2020-08-09 |
| 32766537 | Tocilizumab was approved for chimeric antigen receptor T-cell therapy induced cytokine release syndrome and it may provide clinical benefit for selected COVID-19 patients. […] The median time to clinical improvement in tocilizumab vs. no tocilizumab cohorts was 8 days (Interquartile range [IQR]: 6·25 - 9·75 days) vs. 13 days (IQR: 9·75 - 15·25 days) among patients who required mechanical ventilation at any time (Hazard ratio for clinical improvement: 1·83, 95% confidence interval [CI]: 0·57 - 5·84) and 6·5 days vs. 7 days among all patients (Hazard ratio for clinical improvement: 1·14, 95% CI: 0·55 - 2·38), respectively. […] Although not statistically significant, tocilizumab also resulted in shorter median time to clinical improvement and shorter duration of invasive ventilation. […] These findings require validation from ongoing clinical trials of Tocilizumab in COVID-19 patients. | 2020-08-09 |
| 32766538 | This is a retrospective observational study based on chart review of patients presenting to the Emergency Department of HPG23 from 29/02/2020 to 10/03/2020 with a clinical condition highly suspicious for COVID-19 infection. | 2020-08-09 |
| 32766541 | Patients with COVID-19 were retrospectively analyzed and clinical characteristics were compared. | 2020-08-09 |
| 32766542 | Studies summarizing the clinical picture of COVID-19 in children are lacking. […] This review characterizes clinical symptoms, laboratory, and imaging findings, as well as therapies provided to confirmed pediatric cases of COVID-19. […] We included published or in press peer-reviewed cross-sectional, case series, and case reports providing clinical signs, imaging findings, and/or laboratory results of pediatric patients who were positive for COVID-19. […] Although fever (59·1%) and cough (55·9%) were the most frequent symptoms 19·3% of children were asymptomatic. | 2020-08-09 |
| 32766545 | 29.8%, 13.5% and 24.1% HWs reported stress, depression and anxiety symptoms. | 2020-08-09 |
| 32766546 | The objective of this study was to characterize the demographics, clinical manifestations, and outcomes in this unique patient population. […] Most patients were asymptomatic on admission (46.3%), of whom 35 later developed symptoms, and 59.7% had no signs of infection. | 2020-08-09 |
| 32766562 | In the multivariate analysis, younger age (< 65 yr) (odds ratio, 2.14; 1.17-4.03), time between onset of symptoms and antiviral administration greater than or equal to 7 days (odds ratio, 2.39; 1.27-4.73), and use of neuromuscular blockers greater than or equal to 7 days (odds ratio, 1.89; 1.05-3.43) were independently associated with pulmonary embolism. | 2020-08-09 |
| 32766563 | Video-telecommunication use facilitated clinical research while minimizing unnecessary exposure to coronavirus disease 2019 and conserving personal protective equipment. | 2020-08-09 |
| 32766565 | This study was conducted to determine whether noninvasive urine biomarkers can predict the clinical severity of coronavirus disease 2019. | 2020-08-09 |
| 32766566 | Patients’ demographic data, comorbidities, laboratory values, treatments, and clinical outcomes were collected. | 2020-08-09 |
| 32766567 | Emergency department patients receiving lung ultrasound for clinical suspicion of coronavirus disease 2019 during the study period. […] The strongest combination of clinical, chest radiograph, and lung ultrasound factors for diagnosis was nondependent bilateral pulmonary edema pattern with temperature and oxygen saturation (area under the curve, 0.86; 95% CI, 0.76-0.94; sensitivity = 77% [58-93%]; specificity = 76% [53-94%] at the ideal cutoff), which was superior to chest radiograph alone. | 2020-08-09 |
| 32766569 | To determine whether Seraph-100 (Exthera Medical Corporation, Martinez, CA) treatment provides clinical benefit for severe coronavirus disease 2019 cases that require mechanical ventilation and vasopressor support. | 2020-08-09 |
| 32766704 | In addition, participants had to complete a survey regarding symptoms and their individual risk of infection. […] Symptoms suspicious for COVID-19 occurred in 72%, fever in 25% of all subjects. […] None of these was free from COVID-19 suspicious symptoms. | 2020-08-09 |
| 32766706 | Clinical presentation was recognized as the most important reason for the start of antibiotics (mean score = 4.07 and SD = 1.095 on grading scale from 1 to 5). | 2020-08-09 |
| 32766805 | It also outlines the relevance of findings from this research for clinical care supporting people newly aging with advanced lung disease from COVID-19. | 2020-08-09 |
| 32766815 | However, clinical features, outcomes, and predictors of mortality in SOT recipients are not well-described. | 2020-08-09 |
| 32766817 | Demographic data, laboratory values, comorbidities, treatments, and clinical outcomes were all collected. | 2020-08-09 |
| 32766823 | Detailed clinical analyses of multi-cultural hospitalized patient cohorts remain largely undescribed. […] BAME patients were over-represented in our cohort and, when accounting for demographic and clinical profile of admission, black patients were at increased odds of death. | 2020-08-09 |
| 32766824 | This review highlights the clinical and epidemiologic characteristics of COVID-19 in children and neonates and contrasts these features with other common respiratory viruses. […] There are no distinctive clinical characteristics that will allow the infectious disease consultant to make the diagnosis without laboratory testing. | 2020-08-09 |
| 32766840 | Our data demonstrates that the Diazyme, Roche, and Abbott SARS-CoV-2 serology assays have similar clinical performance. | 2020-08-09 |
| 32766846 | We emphasize the concept that not all cancer patients are at similarly high-risk for a complicated COVID-19 course and the need to develop a roadmap of translational and clinical research on COVID-19 in this challenging group of patients. | 2020-08-09 |
| 32766927 | To reveal that a computed tomography surveillance program (CT-surveillance) could demonstrate the epidemiologic features of COVID-19 infection and simultaneously investigate the type and frequency of CT findings using clinical CT data. […] Using clinical CT data, CT-surveillance program delineated the epidemiologic features of COVID-19 infection. | 2020-08-09 |
| 32767018 | After he returned home and a telephone follow-up, he was found deceased 9 days after first showing symptoms. | 2020-08-09 |
| 32767055 | Due to the difficulty of clinical decision-making during this period, our study group reviewed current literature focusing on the neurological and psychiatric aspects of COVID-19. […] Despite the knowledge on this newly discovered virus which is constantly evolving, different pieces of evidence reported an association between COVID-19 and neurological symptoms like headache, dizziness, taste and smell disorders and complications involving the nervous system eventually triggered by the pathologic processes elicited by SARS-CoV-2. […] Notably, adverse mental health impact has been reported in patients with SARS-CoV-2, which could be related either to the social strain or to the eventual neurotropic effects of the virus, which in other infections have been proven to promote the onset of psychiatric symptoms. | 2020-08-09 |
| 32767137 | Three parents presented with fever or flu-like symptoms at triage; they tested negative on swabs.Conclusion: With universal screening of neonates, parents, and staff, there were no cases of SARS-CoV-2 infection among the neonates admitted to a NICU in an area with a high incidence of SARS-CoV-2. | 2020-08-09 |
| 32767203 | Recently, several scientific associations developed specific guidelines or recommendations to help physicians in their clinical practice. | 2020-08-09 |
| 32767259 | The COVID-19 pandemic caused by SARS-CoV2 is characterized by a remarkable variation in clinical severity ranging from a mild illness to a fatal multi-organ disease. | 2020-08-09 |
| 32767262 | A cross-sectional study was performed to investigate the clinical characteristics, lung CT scan, SARS-CoV-2 nucleic acid test and serum antibodies of hospitalized children with hemato-oncological diseases from January 23 to April 24, 2020. 299 children were enrolled in this study, including 176 males (58.9%) and 123 females (41.1%), aged from 2 months to 16 years. 255 cases (85.3%) received chemotherapy or other immunosuppressive therapies, and there were 44 cases (14.7%) of other benign diseases. | 2020-08-09 |
| 32767265 | This case series aimed to describe the clinical characteristics of severely or critically ill patients with COVID-19 and compare the clinical characteristics of patients who received invasive respiratory support with those of patients who received noninvasive respiratory support. […] Cases were analyzed for epidemiological, demographic, clinical, APACHE II, SOFA, radiological features and laboratory data. […] Common symptoms at onset of illness were fever, fatigue and dry cough. | 2020-08-09 |
| 32767349 | Clinical data were collected, and hospital mortality, hospital length of stay, time of viral clearance, time of mechanical ventilation, and duration from illness onset to symptom resolution were compared between the two groups. […] The duration of symptoms suffering was shorter in the corticosteroid group than non-corticosteroid group, with statistically significant difference (p<0.05). […] Corticosteroid therapy in patients with severe COVID-19 cannot reduce the hospital mortality, and is not associated with delayed viral clearance, but it could relieve the inflammatory storm and improve clinical symptoms in brief. | 2020-08-09 |
| 32767351 | To explore the CT imaging features/signs of patients with different clinical types of Coronavirus Disease 2019 (COVID-19) via the application of artificial intelligence (AI), thus improving the understanding of COVID-19. […] Clinical data and chest CT imaging features of 58 patients confirmed with COVID-19 in the Fifth Medical Center of PLA General Hospital were retrospectively analyzed. […] The CT imaging features of the patients with different clinical types of COVID-19 types were analyzed, and the volume percentage of pneumonia lesions with respect to the lung lobes (where the lesion was located) and to the whole lung was calculated with the use of AI software. […] Common clinical manifestations of COVID-19 patients: fever was found in 47 patients (81.0%), cough in 31 (53.4%) and weakness in 10 (17.2%). […] CT imaging features: there were 48 patients (94.1%) with lesions distributed in both lungs and 46 patients (90.2%) had lesions most visible in the lower lungs; the primary manifestations in patients with common type COVID-19 were ground-glass opacities (GGOs) (23/34, 67.6%) or mixed type (17/34, 50.0%), with lesions mainly distributed in the periphery of the lungs (28/34, 82.4%); the primary manifestations of patients with severe/critical type COVID-19 were consolidations (13/17, 76.5%) or mixed type (14/17, 82.4%), with lesions distributed in both the peripheral and central areas of lungs (14/17,82.4%); other common signs, including pleural parallel signs, halo signs, vascular thickening signs, crazy-paving signs and air bronchogram signs, were visible in patients with different clinical types, and pleural effusion was found in 5 patients with severe/critical COVID-19. […] There were significant differences in the volume percentages of pneumonia lesions for the superior lobe of the left lung, the inferior lobe of the left lung, the superior lobe of the right lung, the inferior lobe of the right lung and the whole lung among patients with different clinical types (p<0.05). […] The clinical and CT imaging features of COVID-19 patients were characteristic to a certain degree; thus, the clinical course and severity of COVID-19 could be evaluated with a combination of an analysis of clinical features and CT imaging features and assistant diagnosis by AI software. | 2020-08-09 |
| 32767466 | The aim of this study was to evaluate the changing trends in dermatology clinical practice at a tertiary center during the coronavirus disease 2019 (COVID-19) pandemic. […] Demographic features, clinical characteristics, dermatologic diseases/complaints, dermatologic procedures/interventions, hospitalization rate, and use of biologic agents were compared between the two groups. […] Updated clinical protocols should be established for the new normal period in accordance with these findings. | 2020-08-09 |
| 32767548 | Point-of-care tests (POCTs) offer considerable potential for improving clinical and public health management of COVID-19 by providing timely information to guide decision-making, but data on real-world performance are in short supply. | 2020-08-09 |
| 32767631 | Despite the optimal pharmacological therapies and different PCI techniques, the final TIMI flow was 0/1 and after 3 hr the clinical condition evolved in cardiac arrest for pulseless electric activity. […] This clinical case suggests that coronary thrombosis in COVID-19 patients may be unresponsive to optimal pharmacological (GP IIb-IIIa infusion) and mechanical treatment (PCI). | 2020-08-09 |
| 32767657 | We estimated that 32/80 (40%) of transmission events were likely to have occurred prior to symptoms onset in primary cases. | 2020-08-09 |
| 32767687 | Although the majority of the patients develop mild symptoms and recover without mechanical ventilation for respiratory management, severe respiratory illness develops in a significant portion of affected patients and may result in death. […] As a result, several clinical trials have been registered using stem cells for COVID-19 treatment that aim to use different cell sources, dosage, and importantly diverse targeted patient groups. | 2020-08-09 |
| 32767703 | In contrast, adults were more likely to develop a severe clinical course compared with children (8.8% vs 0%; P = .021). | 2020-08-09 |
| 32767707 | PEPFAR-supported clinical, laboratory, supply chain, community and data reporting systems can play an important role in mitigating the impact of COVID-19 in sub-Saharan Africa. | 2020-08-09 |
| 32767742 | COVID-19 is predominantly transmitted by respiratory droplets; in the clinical setting, aerosol generating procedures pose the greatest risk for COVID-19 transmission. | 2020-08-09 |
| 32767745 | The spread of the infection and the severe clinical disease have led to the widespread adoption of social distancing measures. | 2020-08-09 |
| 32767755 | Lopinavir/ritonavir, originally developed for treating HIV, is currently undergoing clinical studies for treating the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] The model was validated against multiple observed clinical datasets for single and repeated dosing of lopinavir/ritonavir. […] Predicted pharmacokinetic parameters, such as the maximum plasma concentration, area under the plasma concentration-time profile, oral clearance, half-life, and minimum plasma concentration at steady-state were within two-fold of clinical values for both populations. | 2020-08-09 |
| 32767827 | Such findings warrant intensive efforts from health care institutions to provide psychosocial support services for nurses and ongoing efforts to screen them for traumatic and psychological distress symptoms. | 2020-08-09 |
| 32767867 | The published data has enriched our knowledge on the etiology, epidemiology, clinical manifestations, and pathologic findings of COVID-19. | 2020-08-09 |
| 32767940 | By the infection, common symptoms have been observed like a sudden high fever in between 1 to 9 days and some of the problem in the neck region with starting infection day and then this infection spread into the lungs causes novel coronavirus pneumonia (NCP) and kidney failure. | 2020-08-10 |
| 32768117 | FMTA is not a novel development, and studies have been published during the past two decades that opine on the positive and negative implications of conducting testing and interview procedures online, in forensic and traditionally clinical matters alike. | 2020-08-10 |
| 32768380 | With telehealth clinics (90.5%) and remote inpatient consults (26.2%), both clinical care and resident didactics (86.9%) were increasingly virtual, with similar impact across all program demographics. […] Changes in clinical care delivery dramatically reduced in face-to-face learning opportunities for surgical trainees during the COVID-19 pandemic. | 2020-08-10 |
| 32768466 | MIS-C study metadata were assessed and information on case demographics, clinical symptoms, laboratory measurements, treatments, and outcomes were summarized and contrasted between studies. […] Patients with MIS-C had high prevalence of gastrointestinal (87%), dermatologic/mucocutaneous (73%), and cardiovascular (71%) symptoms. | 2020-08-10 |
| 32768505 | The clinical course of COVID-19 and its ability to rapidly create widespread infection has major implications, warranting vigorous infection prevention and control measures. […] Although vaccines and specific drug therapies have yet to be discovered, ongoing research and clinical trials are being conducted to investigate the efficacy of repurposed drugs for treating COVID-19. | 2020-08-10 |
| 32768693 | Randomized controlled trials of targeted anti-cytokine treatments and corticosteroids should report the duration of cytokine storm in addition to clinical severity at randomization. | 2020-08-10 |
| 32768696 | Demographic and clinical characteristics of patients who have died (including the number of comorbidities) are extremely relevant, especially to define those with a higher risk of mortality. | 2020-08-10 |
| 32768697 | Follow up clinical randomized trials are required to verify the current circumstantial evidence. | 2020-08-10 |
| 32768701 | Clinical characteristics and outcomes were retrospectively analysed of patients - with laboratory-confirmed bilateral COVID-19 pneumonia, hyperinflammation (C-reactive protein (CRP) ≥20 mg/dL), no hypoxaemia (oxygen saturation >90%), and no contraindications to TCZ - who were treated with subcutaneous TCZ (324 mg) administered within 48 h from hospitalization on top of standard of care (SOC). […] Clinical data were available for all patients until death or until day 35 for those discharged from hospital. | 2020-08-10 |
| 32768893 | Mostly, stress and depression are associated with coronavirus disease infection and thus, resulting in weakening of patients’ immune response and hence, more severe respiratory symptoms or even death. […] We propose using a class of antidepressants named selective serotonin reuptake inhibitors for their reported potential antiviral effect, modulatory effect of respiratory symptoms, antioxidant properties and immunoregulatory effects beside their main action as antidepressant. | 2020-08-10 |
| 32768938 | CM can serve as a complementary medication to western medicine, which should be highlighted in clinical settings. | 2020-08-10 |
| 32768971 | The clinical management of COVID-19 has been limited to infection prevention and control measures associated with supportive care such as supplemental oxygen and mechanical ventilation. […] Meanwhile efforts to find an effective treatment to inhibit virus replication, mitigate the symptoms, increase survival and decrease mortality rate are ongoing. […] Several classes of drugs, many of them already in use for other diseases, are being evaluated based on the body of clinical knowledge obtained from infected patients regarding to the natural history and evolution of the infection. | 2020-08-10 |
| 32768974 | The SARS-CoV-2 infection results in a spectrum of non-specific signs and symptoms, ranging from asymptomatic infection, to flu-like illness such as fever, cough, dry cough and fatigue, to pneumonia, acute respiratory distress syndrome, and even multi-organ failures with high morbidity and mortality. […] By 12 June 2020, there are over 1000 clinical trials registered in clinicaltrials.gov for treatment of COVID-19. […] This review summarizes the epidemiology, virology, clinical presentation, pathophysiology, diagnosis, and particularly the antiviral drugs currently under clinical trials for treatment of SARS-CoV-2 infection, together with the challenges and perspectives of this disease are also discussed. | 2020-08-10 |
| 32768975 | However, clinical research data on the effects of QPD on COVID-19 are scarce. […] During the first 14 days of hospitalization, patients with deteriorating symptoms were administered QPD along with Western medicine therapy (the antiviral medicine selected from interferon, lopinavir, or arbidol). […] The clinical characteristics and blood laboratory indices (blood routine, inflammatory factors, and multi-organ biochemical indices) were examined, and the total lung severity scores were evaluated in each patient by reviewing chest computed tomography before treatment and at the end of treatment. […] Before QPD treatment, the combined treatment group showed higher blood C-reactive protein levels and more severe pulmonary inflammation and clinical symptoms than the Western medicine treatment group. | 2020-08-10 |
| 32769023 | Using 168 samples from patients hospitalized for COVID-19, non-hospitalized patients but infected with SARS-CoV-2, patients participating in screening campaigns, and samples from patients with a history of other seasonal coronavirus infections, we evaluated the clinical performance of 5 serological assays widely used worldwide (WANTAI®, BIORAD®, EUROIMMUN®, ABBOTT® and LIAISON®). […] For hospitalized patients, all these assays showed a sensitivity of 100 % from day 9 after the symptoms onset. | 2020-08-10 |
| 32769024 | The specificity and sensitivity of the binding IgG assay was highest for S protein with a specificity of 97.4 % and sensitivity of 96.2 % for samples taken 14 days and 97.9 % for samples taken 21 days following the onset of symptoms. […] Excellent sensitivity for IgG detection was obtained over 14 days since onset of symptoms for three SARS-CoV-2 antigens (S, RBD and N) in this multiplexed assay which can also measure antibody functionality. | 2020-08-10 |
| 32769025 | Assessment of the two assays was performed prospectively in three reference Parisians hospitals, using 170 clinical samples. | 2020-08-10 |
| 32769038 | Many clinical trials proved the efficacy and tolerability of different monotherapies and combinations of chemotherapeutic agents administered in metronomic doses and frequencies in ABC. | 2020-08-10 |
| 32769089 | Epidemiological and clinical findings of child index case-household secondary case pair was assessed. | 2020-08-10 |
| 32769128 | To examine whether HbA1c, outpatient diabetes treatment regimen, demographics, and clinical characteristics are associated with mortality in hospitalized patients with diabetes and coronavirus disease 2019 (COVID-19). […] Multivariate modeling was used to assess the independent association of HbA1c levels and outpatient diabetes treatment regimen with mortality, in addition to independent effects of demographic and clinical characteristics. | 2020-08-10 |
| 32769150 | The covariates were sociodemographic, clinical and treatments. […] The mean age on admission was 69.7 (15.7) years, and the median time from onset of symptoms to hospital admission was 5 (3-10) days. | 2020-08-10 |
| 32769214 | This review summarises the clinical and scientific basis for the potential use of saliva for COVID-19 diagnosis and disease monitoring. […] Additionally, we discuss saliva-based biomarkers and their potential clinical and research applications related to COVID-19. | 2020-08-10 |
| 32769228 | The goal of perinatal medicine is to provide professionally responsible clinical management of the conditions and diagnoses of pregnant, fetal, and neonatal patients. | 2020-08-10 |
| 32769230 | We describe the demographic, clinical and laboratory findings along with the treatment and outcomes among children meeting the case definition of Pediatric Inflammatory Multisystem Syndrome - Temporally Associated with SARS-CoV-2 (PIMS-TS). […] We analyzed the clinical and laboratory findings of children who presented with PIMS-TS during an 8-week period from May 4, 2020 to July 8, 2020. […] Multi organ involvement (79%), mucocutaneous involvement (74%), cardiovascular symptoms (63%) and gastrointestinal symptoms (42%) were the other features. […] Children with PIMS-TS present with a wide range of signs and symptoms. | 2020-08-10 |
| 32769260 | Abnormalities in albumin and prealbumin levels are common among COVID-19 patients and hypoprealbuminemia independently predicts adverse outcome and should be carefully considered in clinical practice. | 2020-08-10 |
| 32769322 | The clinical spectrum varies in symptomatic and asymptomatic patients, who later become potential silent carriers, thus unknowingly spreading the virus. | 2020-08-10 |
| 32769398 | This clinical picture is consistent with dysregulation of many of the molecular pathways in which ADAM17 participates. | 2020-08-10 |
| 32769401 | In addition, clinical practice guidelines provide no clear consensus on the role of chloroquine or hydroxychloroquine for the management of COVID-19. | 2020-08-10 |
| 32769623 | Of 49 mechanically ventilated coronavirus disease 2019, 40 underwent CT pulmonary angiography after a median of 7 days (4-8 d) since ICU admission and 12 days (9-16 d) days since the onset of symptoms. | 2020-08-10 |
| 32769760 | However, current data have appeased such concerns because there has been no clinical evidence of a harmful effect of these agents as based on observational studies. | 2020-08-10 |
| 32769869 | We will conduct a systematic review based on searches of major databases (eg, Pubmed, Web of Science, EMBASE, CENTRAL, MEDLINE, SCI-EXPANDED, CPCI-S, CBM, CNKI, and Wanfang Database) and clinical trial registries from inception to present without limitations of language and publication status. | 2020-08-10 |
| 32769874 | In addition, Clinical trial registries, like the Chinese Clinical Trial Registry, the Netherlands National Trial Register and ClinicalTrials.gov, will be searched for ongoing trials with unpublished data. […] The primary outcome will be the time of disappearance of main symptoms (including fever, asthenia, cough disappearance rate, and temperature recovery time), and serum cytokine levels. […] The secondary outcome will be the accompanying symptoms (such as myalgia, expectoration, stuffiness, runny nose, pharyngalgia, anhelation, chest distress, dyspnea, crackles, headache, nausea, vomiting, anorexia, diarrhea) disappear rate, negative COVID-19 results rate on 2 consecutive occasions (not on the same day), CT image improvement, average hospitalization time, occurrence rate of common type to severe form, clinical cure rate, and mortality. | 2020-08-10 |
| 32769892 | The clinical features included fever, respiratory symptoms, and gastrointestinal symptoms. […] In terms of clinical manifestations, 13 cases had fever, which was close to the number of cases without fever (13 cases). […] The respiratory symptoms included dry cough (19 cases), shortness of breath (9 cases), fatigue (11 cases), and so forth. […] Sore throat (2 cases) was not significant, and a few patients reported gastrointestinal symptoms (3 cases). | 2020-08-10 |
| 32769893 | Safety in clinical work is of priority as elective surgery in the department of surgery progressing. […] We used checklists based on our experiences on COVID-19 control and reality of clinical work from February to March in the West China Hospital, involving events of screening patient, chaperonage, and healthcare workers. […] Checklist summarized the actual clinical nursing work and management practices, hope to provide a reference for the order of surgery during the epidemic prevention and control, and standardize the clinical nursing work of surgery during pandemic. | 2020-08-10 |
| 32769902 | Clinical and biological criteria led to the diagnosis of MAS; cytokine profile was highly suggestive reverse transcription polymerase chain reaction for SARS-CoV-2 in nasopharyngeal swabs was negative, but serum anti-SARS-CoV-2 immunoglobulin A and immunoglobulin G resulted positive leading to the diagnosis of SARS-CoV-2 infection. […] Clinical improvement ensued. | 2020-08-10 |
| 32769921 | This study will evaluate the efficacy and safety of the Shufeng Jiedu capsule in the treatment of COVID-19 and provide a more reasonable choice of medication in clinical practice. […] Our findings will provide references for future clinical decision and guidance development. | 2020-08-10 |
| 32769922 | Western medicine routine treatment combined with Chinese herbal medicine is an alternative clinical option but lacks evidence-based medical evidence. […] The primary outcome will be the clinical cure rate. […] The secondary outcome will be accounting symptoms, fever time, time of virus nucleic acid turning negative, check the condition by drawing blood, pneumonia absorption rate, patient hospitalization time, severe conversion rate and case fatality rate, adverse reactions, and adverse events. | 2020-08-10 |
| 32770180 | Further, clinical, community-based, and translational research has been disrupted by heightened safety precautions and social distancing which may affect BIPOC representation in research downstream. | 2020-08-10 |
| 32770240 | In the pilot stage of Phase II/III clinical trial, AVIFAVIR enabled SARS-CoV-2 viral clearance in 62.5% of patients within 4 days, and was safe and well-tolerated. | 2020-08-10 |
| 32770277 | Nine patients had documented preoperative COVID-19 symptoms and one perioperative death was reported. | 2020-08-10 |
| 32770341 | Retrospective review of consecutive PDT procedures performed by neurointensivists on intubated adult patients with COVID-19 using the AerosolVE tent during the pandemic under an innovative clinical care protocol. | 2020-08-10 |
| 32770414 | Taking into account that GBS can cause a considerable impairment of the respiratory system, clinicians dealing with SARS-CoV-2 positive-tested patients should pay attention to symptoms of the peripheral nervous system. | 2020-08-10 |
| 32770449 | Symptoms of severe burnout, anxiety and depression were collected. […] The prevalence of symptoms of anxiety and depression or severe burnout was 46.5%, 30.2%, and 51%, respectively, and varied significantly across regions. […] Factors independently associated with symptoms of severe burnout included age (HR 0.98/year [0.97-0.99]) and clinician’s rating of the ethical climate (HR 0.76 [0.69-0.82]). | 2020-08-10 |
| 32770646 | The clinical course could be ranging from mild to severe illness especially the individuals with an immunocompromised condition such as solid organ transplant recipients. […] The study focused on the clinical course and management of our cases. […] Clinical presentation and severity of our case series are variable depending on each individual immune status. | 2020-08-10 |
| 32770652 | A large majority of these patients are in high-risk categories, and many specialized clinical practices are vulnerable. […] To discuss the threats and opportunities from the COVID-19 pandemic for SLTs in ENT/laryngology with specific reference to clinical practice, workforce and research leadership. […] The main threats to ENT/laryngology SLT clinical services include increased patient complexity related to COVID-19 voice and airway problems, delayed HNC diagnosis, reduced access to instrumental procedures and inequitable care provision. […] The main clinical opportunities include the potential for new modes of service delivery and collaborations, and harnessing SLT expertise in non-instrumental assessment. […] The immediate impact of the pandemic has resulted in major disruption to all aspects of clinical delivery, workforce and research for ENT/laryngology SLT. […] It is unclear when any of these areas will resume operations and whether permanent changes to clinical practice, professional remits and research priorities will follow. […] The diverse scope of clinical practice involves highly specialized assessment and treatment practices in patients in high-risk categories. […] The COVID-19 pandemic has created both opportunities and threats for ENT SLT clinical services, workforce and research. […] What this paper adds to existing knowledge This study provides a discussion of the threats and opportunities from the COVID-19 pandemic for ENT/laryngology SLT with specific reference to clinical practice, workforce and research leadership. […] What are the potential or actual clinical implications of this work? […] The COVID-19 pandemic has resulted in major disruption to all aspects of clinical delivery, workforce and research for ENT/laryngology SLT. […] Changes to clinical practice, professional remits and research priorities are of indeterminant duration at this time, and some components could be permanent. […] Significant clinical practice, workforce and research opportunities may exist in the post-COVID era. | 2020-08-10 |
| 32770653 | This rapid review provides an evaluation of current evidence with input from clinical experts to produce guidance for screening for active COVID-19 in a low prevalence setting. […] Findings were streamlined for clinical relevance through the advice of an expert working group that included seven senior surgeons and a senior medical virologist. […] Hyposmia and hypogeusia may present as early symptoms of COVID-19, and can potentially discriminate from other influenza-like illnesses. […] Reverse transcription-polymerase chain reaction is the gold standard diagnostic test to confirm SARS-CoV-2 infection, and although sensitivity can be improved with repeated testing, the decision to retest should incorporate clinical history and the local supply of diagnostic resources. […] Through a rapid review of the literature and advice from a clinical expert working group, evidence-based recommendations have been produced for the preoperative screening of surgical patients with suspected COVID-19. | 2020-08-10 |
| 32770687 | The purpose of this study was to assess whether lung ultrasound (LUS) is an effective indicator of subclinical residual lung damage in patients with COVID-19 who meet discharge criteria. […] Lung ultrasound can identify the persistence of subclinical residual lung damage in patients with severe COVID-19 even if they meet discharge criteria. | 2020-08-10 |
| 32770691 | Here, we report the clinical courses of three critically ill patients with COVID-19 receiving CP treatments by total immunoglobulin G (IgG) titer collection. […] Three patients with COVID-19 in this study were laboratory confirmed to be positive for SARS-CoV-2, with radiographic and clinical features of pneumonia. […] The clinical courses of these patients, including laboratory results and pulmonary functional and image studies after receiving convalescent plasma infusions, were reviewed. | 2020-08-10 |
| 32770717 | Rash occurred before onset of other symptoms was in 5.3% patients. | 2020-08-10 |
| 32770738 | Following the announcement of first coronavirus disease 2019 (COVID-19) case on March 11, 2020, in Turkey we aimed to report the co-infection rates, and the clinical, laboratory, radiological distinctive features of viral pneumonia caused by viruses other than severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] Some clinical, laboratory and radiological findings may help in the differential diagnosis of non-SARS-CoV-2 viruses from COVID-19. | 2020-08-10 |
| 32770758 | A large number of scientific papers have been produced, hundreds of thousands of patients have been hospitalized and studied, several treatments and vaccines are being tested in randomized clinical trials, social distancing regulations have been implemented, with most of the planet in partial or full lockdown, and we have yet to control this pandemic. | 2020-08-10 |
| 32770768 | The vitamin D binding protein (DBP) with emphasis on its regulation of total and free vitamin D metabolite levels in various clinical conditions. | 2020-08-10 |
| 32770797 | The clinical, laboratory and imaging data of eleven patients with severe COVID-19 pneumonia were collected to investigate the evolution process of severe COVID-19 cases. | 2020-08-10 |
| 32770854 | However, there is noticeable the lack of clinical trials that confirm the efficacy, security, absence of side effects in the short and long term, and the effective doses of melatonin. […] Melatonin has significant anti-inflammatory, antioxidant, and mitochondrial protective effects, and its efficacy has been demonstrated in multiple experimental models of disease and in a clinical trial in sepsis. […] Nevertheless, there is a lack of experimental and clinical data on the use of melatonin on SARS-CoV-2 infection. […] Accordingly, we designed a clinical trial with an injectable formulation of melatonin for intravenous perfusion in ICU patients suffering from COVID-19 that has been just approved by the Spanish Agency of Medicines and Medical Devices (AEMPS). | 2020-08-10 |
| 32770858 | COVID-19 is a new virus from the family of coronaviruses that can cause symptoms ranging from a simple cold to pneumonia. | 2020-08-10 |
| 32770973 | To this date little information exists on the effects, clinical course and outcome of the COVID-19 among patients undergoing transplantation. […] A 35 year old male referred with loss of sense of smell and taste after having close contact with his brother who was diagnosed with COVID-19 five days prior to his symptoms. […] The patient referred to a local physician with mild symptoms of fatigue, cough, myalgia, dizziness, and nausea/vomiting with a fear of contracting the disease. […] Our patient who had liver transplantation and COVID-19 did not present more severe symptoms compared to his counterpart without liver transplantation and did not need to be hospitalized or be given antiviral drugs for COVID-19. | 2020-08-11 |
| 32771032 | To evaluate the effectiveness of Hydroxychloroquine Phosphate/Sulfate (200 mg orally 8 hourly thrice a day for 5 days), versus oseltamivir (75 mg orally twice a day for 5 days), and versus Azithromycin (500 mg orally daily on day 1, followed by 250 mg orally twice a day on days 2-5) alone and in combination (in all seven groups), in clearing the coronavirus (COVID-19) nucleic acid from throat and nasal swab and in bringing about clinical improvement on day 7 of follow-up (primary outcomes). […] An adaptive design, set within a comprehensive cohort study, to permit flexibility in this fast-changing clinical and public health scenario. […] The clinical primary outcome will be improvement from baseline of two points on a seven-category ordinal scale of clinical status on day 7 of follow-up. […] The study protocol has been reported in accordance with the Standard Protocol Items: Recommendations for Clinical Interventional Trials (SPIRIT) guidelines (Additional file2). | 2020-08-11 |
| 32771034 | Prospective, two-arm, parallel-group, randomised (1:1 allocation ratio), open-label, controlled, exploratory phase II clinical trial of oral NS oil in patients with mild COVID-19. […] Inclusion Criteria: - Patients with mild COVID19 (defined as upper respiratory tract infection symptoms in the absence of clinical or radiological signs of pneumonia). - Adult (18 - 65 years old). - Written informed consent by the patient (or legally authorized representative) prior to initiation of any study procedures. - All patients should understand and agree to comply with planned study procedures. - Polymerase chain reaction (PCR)-confirmed infection with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) from throat swab. - Patients with pneumonia or severe illness requiring admission to intensive care unit. - Severe chronic kidney disease (i.e. estimated glomerular filtration rate [eGFR] < 30 mL / min) or end stage renal disease requiring dialysis - Severe chronic liver disease (Alanine transaminase [AlT] or Aspartate transaminase [AST] > 5 times the upper limit of normal). - Pregnancy or breast feeding. - Anticipated transfer within 72 hours to another hospital that is not a study site. - Allergy to the study medication The trial is currently conducted on patients recruited from King Abdulaziz University Hospital, Jeddah, Saudi Arabia. […] Proportion of patients who clinically recovered (defined as 3 days of no symptoms) within 14 days after randomisation. | 2020-08-11 |
| 32771035 | Due to clinical and methodological heterogeneity, we did not conduct a meta-analysis. | 2020-08-11 |
| 32771053 | We aimed at describing delirium and neurological symptoms of COVID-19 in ICU patients. […] The secondary endpoints were to describe the characteristics of delirium, to compare the duration of invasive mechanical ventilation and ICU length of stay in patients with and without delirium and/or abnormal neurological symptoms. […] The delirium/neurological symptoms in COVID-19 patients were responsible for longer mechanical ventilation compared to the patients without delirium/neurological symptoms. […] Delirium/neurological symptoms could be secondary to systemic inflammatory reaction to SARS-CoV-2. […] Delirium/neurological symptoms in COVID-19 patients are a major issue in ICUs, especially in the context of insufficient human and material resources. | 2020-08-11 |
| 32771058 | She received 5 days of oral hydroxychloroquine and experienced resolution of her symptoms. […] Clinicians must be aware of uncommon clinical and radiological findings in order to diagnose this entity. […] More data are needed to establish the clinical impact of this novel finding. | 2020-08-11 |
| 32771068 | It is hypothesised that the intervention will: 1) reduce insomnia severity in poor sleepers, compared to wait-list control poor sleepers, and good sleepers; 2) reduce subjective symptoms of anxiety and depression in all groups, and 3) prevent the transition to acute insomnia in good sleepers. […] The study protocol has been reported in accordance with the Standard Protocol Items: Recommendations for Clinical Interventional Trials (SPIRIT) guidelines (Additional file 2). | 2020-08-11 |
| 32771089 | Although an interruption in the supply of ART drugs would have the largest impact of any potential disruptions, effects of poorer clinical care due to overstretched health facilities, interruptions of supply of other drugs such as co-trimoxazole, and suspension of HIV testing would all have a substantial effect on population-level mortality (up to a 1·06 times increase in HIV-related deaths over a 1-year period due to disruptions affecting 50% of the population compared with no disruption). | 2020-08-11 |
| 32771222 | The main purpose of this study was to evaluate the correlation between LUS findings and chest CT in patients confirmed to have (positive reverse transcription polymerase chain reaction [RT-PCR]) or clinically highly suspected of having (dyspnea, fever, myasthenia, gastrointestinal symptoms, dry cough, ageusia or anosmia) COVID-19. […] An experienced emergency department physician performed the LUS exam blind to the clinical history and results of the CT scan, which were reviewed by two radiologists in consensus for signs compatible with COVID-19 (bilateral ground-glass opacities in peripheral distribution). | 2020-08-11 |
| 32771236 | A series of findings, relationships and behavioral patterns between the infectious agent and the child host may account for the lower incidence and a greatly attenuated clinical presentation of the disease in children. | 2020-08-11 |
| 32771272 | A scoping review of registered clinical trials of convalescent plasma for COVID-19 was conducted to assess the feasibility of performing a rapid and timely meta-analysis that will support accelerated review for approval and implementation. […] ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform were searched April 23, 2020. | 2020-08-11 |
| 32771308 | An anonymous online questionnaire using a snowball sampling method was conducted from March 19-26, 2020 and included sociodemographic and clinical data along with the DASS-21 and IES scales. […] In the SMD group, higher anxiety was associated with being single (beta = 0.144), having COVID-19 symptoms (beta = 0.146), and a higher score on the stress subscale of DASS-21 (beta = 0.538); whereas being able to enjoy free time was a protective factor (beta = -0.244). | 2020-08-11 |
| 32771432 | The control strategies preventing subclinical transmission differed among countries. […] Three strategies included lack of prevention of subclinical transmission (Strategy A), partial prevention using testing with different accuracy (Strategy B) and complete prevention by isolating all at-risk people (Strategy C, Taiwan policy). | 2020-08-11 |
| 32771461 | In the absence of clinical trial results, physicians must use what has been learned about the pathophysiology of SARS-CoV-2 infection in determining early outpatient treatment of the illness with the aim of preventing hospitalization or death. | 2020-08-11 |
| 32771632 | To delineate clinical characteristics of asymptomatic and symptomatic patients confirmed with COVID-19 in South Korea. […] In this national cohort of over 10,000 patients with COVID-19, more than 60% of all cases in South Korea reported no symptoms at the time of diagnosis. | 2020-08-11 |
| 32771634 | The clinical onset serial interval is often used as a proxy for the transmission interval of an infectious disease. […] For SARS-CoV-2/COVID-19, data on clinical onset serial intervals is limited, since symptom onset dates are not routinely recorded and do not exist in asymptomatic carriers. […] Based on the DS4C project data on SARS-CoV-2/COVID-19 in South Korea, we estimate the means of the diagnostic serial interval, the clinical onset serial interval, and the difference between the two. […] The diagnostic serial interval was significantly shorter than the clinical onset serial interval (estimated mean difference -1.12 days, 95% CI: -1.98, -0.26). | 2020-08-11 |
| 32771635 | New loss of smell or taste was not included among the common symptoms of COVID-19 until March 2020 when the pandemic started in Western countries. […] We retrospectively investigated the clinical features of confirmed cases of COVID-19 in Nord Franche-Comté Hospital, Trevenans, France, between March, 1st and March, 14th 2020. […] Fatigue (93%[65]), cough (80%[55]), and fever (77%[54]) were the three main symptoms. […] Neurologic symptoms were present in more than half of the patients: anosmia (53%[37]) and dysgeusia (48%[34]). | 2020-08-11 |
| 32771637 | We report the case of a full-term neonate born to a mother who developed symptoms of coronavirus disease 2019 (COVID-19) at 32 weeks of gestation. […] The neonate had no symptoms of COVID-19. | 2020-08-11 |
| 32771638 | Throat swabs were collected from 128 (5.1%) passengers and crew members with fever or respiratory symptoms during the past 14 days or travel history to China, Hong Kong, or Macao within 30 days. | 2020-08-11 |
| 32771639 | Telephone follow-up at 1 and 2 months and clinical contact within 3 months was initiated; demographic, clinical, radiologic and laboratory data were recorded in electronic medical records and updated. […] At 1 and 2 months none has died and none has had any signs of recurrence of infectious at both telephone interview and clinical visit. […] Our clinical observation have confirmed two basic points: the reinfection is very unlikely and any antibody immunity protects against recurrence, at least in the short term. | 2020-08-11 |
| 32771640 | To better understand this, we used multiparameter flow cytometry to profile circulating leukocytes from non-immunocompromised adult patients with PCR-proven COVID-19 and specifically compared those with mild symptoms with those who had developed pneumonia. […] Understanding the innate immune response to SARS-CoV-may uncover why most infected individuals experience mild symptoms, and inform a preventive approach to COVID-19 pneumonia in the future. | 2020-08-11 |
| 32771682 | Animal, in vitro and clinical data relevant to the biology of the renin-angiotensin system (RAS), its interaction with the kallikrein-kinin system (KKS) and SARS-CoV-2, and clinical studies were reviewed. | 2020-08-11 |
| 32771797 | The major clinical symptoms of 2019-nCoV infection include fever, dry cough, myalgia, fatigue, and diarrhea. […] Their potential targets, activity, clinical status and side effects are described. | 2020-08-11 |
| 32771883 | Symptoms started 2-7 days before admission, and consisted of fever (64 %), cough (59 %), and dyspnea (57 %). […] Elderly patients with COVID-19 infection have a similar clinical course to younger individuals. […] Previous treatment with RAAS inhibitors, and demographic, clinical and laboratory data influence prognosis. | 2020-08-11 |
| 32771888 | Residents were asked about their routinely activity before the COVID-19 pandemic, and to report the reduction in their clinical practice. […] They were also asked about psychological impact of COVID-19 on their clinical practice. | 2020-08-11 |
| 32771918 | Detailed history, anthropometry, laboratory investigations, imaging studies, clinical course and management outcomes were documented. | 2020-08-11 |
| 32771941 | Neurologic symptoms have been reported in some COVID-19 patients. […] However, little is known on what factors influence the risk of developing these symptoms. […] While some studies suggest that exposure to pollution is associated with higher rates of SARS-CoV-2 infection, its role is unknown in the development of neurologic symptoms in COVID-19 patients. […] This article explores the hypothesis that the neurologic symptoms in COVID-19 may be exacerbated through a neuroinflammatory mechanism that is promoted by environmental pollutant exposure. | 2020-08-11 |
| 32771946 | Patients with COVID-19 were reactive (positive) for specific antibodies within 3-15 days after onset of symptoms. | 2020-08-11 |
| 32772069 | In this study, we evaluated the association between use of methylprednisolone and key clinical outcomes. […] Clinical outcomes associated with the use of methylprednisolone were assessed in an unmatched, case-control study; a subset of patients also underwent propensity-score matching. | 2020-08-11 |
| 32772172 | High dose steroids followed by plasma exchange were administered, and the patient made a clinical recovery. | 2020-08-11 |
| 32772307 | Although the clinical symptoms mostly have been characterized, the scientific community still doesn´t know how SARS-CoV-2 successfully reaches and spreads throughout the central nervous system (CNS) inducing brain damage. […] However, clinical trials elucidating the efficacy of melatonin in the prevention and clinical management in the COVID-19 patients should be actively encouraged. | 2020-08-11 |
| 32772324 | In this retrospective, observational study, we analysed demographic, clinical and laboratory data of 42 patients with acute respiratory failure due to COVID-19, treated in Respiratory Intermediate Care Unit (RICU) of the Policlinic of Bari from March, 11 to April 30, 2020. […] No differences regarding demographic and clinical characteristics were found. | 2020-08-11 |
| 32772375 | A prospective clinical study compared SARS-CoV-2 and human cellular material recovery by 3D-printed swabs and standard nasopharyngeal swabs. […] Participants in the clinical evaluation were 50 hospital staff members attending a COVID-19 screening clinic and two inpatients with laboratory-confirmed COVID-19. […] In the clinical evaluation, a flocked nasopharyngeal swab sample was collected with the Copan ESwab and a mid-nasal sample from the other nostril was collected with the 3D-printed swab. […] In the clinical evaluation, qualitative agreement with regard to RNase P detection (a surrogate measure of adequate collection of human cellular material) in samples collected from 50 hospital staff members with standard and 3D-printed swabs was complete. | 2020-08-11 |
| 32772434 | To determine the well-being of urologists worldwide during the coronavirus disease 2019 pandemic, and whether they have adequate personal protective equipment knowledge and supplies appropriate to their clinical setting. | 2020-08-11 |
| 32772538 | Because COVID-19 has already begun to precipitate huge increases in mental health problems, clinical psychological science must assert a leadership role in guiding a national response to this secondary crisis. […] Urgent challenge areas across developmental periods are discussed, followed by a review of psychological symptoms that likely will increase in prevalence and require innovative solutions in both science and practice. […] Implications for new research directions, clinical approaches, and policy issues are discussed to highlight the opportunities for clinical psychological science to emerge as an updated, contemporary field capable of addressing the burden of mental illness and distress in the wake of COVID-19 and beyond. | 2020-08-11 |
| 32772679 | Using our institutional electronic health record, we extracted clinical characteristics of the cohort, including age, sex, and comorbidities. | 2020-08-11 |
| 32772702 | The rapidity of COVID-19 public health measures instituted in Australia required swift action for medical education to address lockdowns of student clinical placements. […] The responses included a transition to interim online learning followed by a return to truncated clinical placements renegotiated to conform to public health measures. | 2020-08-11 |
| 32772722 | In this retrospective study, the clinical effectiveness of intravenous (IV) infusion of flucloxacillin using an elastomeric device was explored in a convenience sample of patients. […] Thus, the clinical effectiveness of Accufuser antibiotic infusion varies among patients with different infective diagnoses, and there seems to be a complex relationship between the method of antibiotic delivery and the patient’s condition. | 2020-08-11 |
| 32772880 | However, a recent literature review found no studies evaluating the use of telehealth technology as a means of precepting in clinical training. […] Clinical factors, logistics, and comparison with traditional precepting are discussed. […] Interviewees viewed teleprecepting as a viable method of increasing access to clinical training. […] This project supports teleprecepting as a feasible strategy for improving access to clinical training and as a technological resource that merits systematic evaluation. | 2020-08-11 |
| 32772930 | As the peak phase passes, re-activation plans are required to safely manage increasing clinical volumes. | 2020-08-11 |
| 32773098 | Although the clinical spectrum of Covid-19 is variable, acute respiratory failure and systemic coagulopathy are common in severe Covid-19 patients. | 2020-08-11 |
| 32773101 | SARS-CoV-2 belongs to Coronaviridae family and causes the deadliest clinical manifestations when compared to other viruses in the family. | 2020-08-11 |
| 32773102 | Controlled clinical trials and preclinical models of COVID-19 are needed to evaluate this hypothesis. | 2020-08-11 |
| 32773103 | The rapid onset and worldwide spread of the COVID-19 epidemic (caused by SARS-CoV-2 coronavirus) has been associated with a profound impact in clinical practice also in the hematologic setting. […] In particular, as regards allogeneic (and to a lesser extent autologous) hematopoietic cell transplantation and CAR T-cell therapy, specific recommendations have been issued by the transplant community on the criteria to be used to decide whether or not to postpone these procedures and on the clinical management of recipients and donors exposed to COVID-19. […] As to cytotoxic chemotherapy and other antineoplastic therapies, criteria have been proposed to decide, in the various clinical situations, which treatments were not deferrable and which instead could be postponed or replaced by less aggressive therapies. […] In the outpatient clinics, various organizational solutions for telemedicine have been adopted, resorting to telephone interviews and/or Information Technology, with the aim of reducing the influx of patients while maintaining an adequate control of their clinical condition. […] The collection of blood by the transfusion centers has been the subject of organizational measures, in order to avoid the transmission of COVID 19 while maintaining a sufficient blood collection for clinical needs. | 2020-08-11 |
| 32773165 | The electronic medical records of patients that discharged or died from COVID-19 in the Hospital Universitario San Cecilio (Granada, Spain) between March 16 and April 10, 2020 were analysed. […] From these records, information was obtained on sex, age, comorbidities at admission, clinical information, analytical parameters, imaging tests and empirical treatments used. […] It seems necessary to design randomized controlled clinical trials that evaluate the possible protector effect of tocilizumab and corticoids in the risk of mortality for some subgroups of COVID-19 hospitalized patients. | 2020-08-11 |
| 32773182 | Academicians who maintain a critical care clinical practice encounter numerous stressors, especially during the COVID-19 pandemic, which can influence well-being. | 2020-08-11 |
| 32773212 | Unfortunately, clinical outcomes reported for antivirals are not consistent. | 2020-08-11 |
| 32773215 | Coronavirus disease 2019 (COVID-19; severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] has dislocated clinical services and postgraduate training. | 2020-08-11 |
| 32773257 | Various symptoms of patients infected with COVID-19 indicated the importance of immune regulation in the human body. | 2020-08-11 |
| 32773262 | We present the clinical characteristics and outcomes of 28 COVID-19 patients treated in our hospital in Taiwan. […] Their clinical characteristics and outcomes were reviewed. […] The most frequent symptoms were cough (n = 23, 82.1%) and fever (n = 17, 60.7%). | 2020-08-11 |
| 32773328 | Although the knowledge on the clinical and epidemiology of COVID-19 in pediatric patients is being accumulated rapidly, relevant comprehensive review on its radiological manifestations is still lacking. | 2020-08-11 |
| 32773400 | One of the critical factors behind the rapid spread of COVID-19 pandemic is a lengthy clinical testing time. | 2020-08-11 |
| 32773403 | The crisis put enormous pressure on all hospital services, including the clinical ethics consultation team. […] We also aim to highlight the role of the clinical ethics consultant as well as areas of policy and law that may need to be addressed in order to be better prepared for a future public health crisis. | 2020-08-11 |
| 32773404 | In this article, we describe our experience over an eight-week period (16 March through 10 May 2020), and describe three types of services: clinical ethics consultation (CEC); service practice communications/interventions (SPCI); and organizational ethics advisement (OEA). […] We note that there were times during the crisis that serving in the role of clinical ethics consultant created a sense of dis-ease as novel as the coronavirus itself. […] In retrospect we learned that our activities far exceeded the familiar terrain of clinical ethics consultation and extended into other spheres of organizational life in novel ways that were unanticipated before this pandemic. | 2020-08-11 |
| 32773405 | The COVID-19 pandemic that struck New York City in the spring of 2020 was a natural experiment for the clinical ethics services of NewYork-Presbyterian (NYP). […] While Weill Cornell and Columbia saw a surge in clinical ethics consultations, the two services assumed a more expansive role than one normally played in institutional life. […] The COVID-19 surge in New York City revealed latent capabilities in ethics consultation that may prove useful to the broader clinical ethics community as it responds to the current pandemic and reconceptualizes its potential for future service. | 2020-08-11 |
| 32773409 | This review provides an update on clinical features, diagnosis, epidemiology, management and prevention of coronavirus disease 2019 (COVID-19) in children. […] Specific characteristics noted in children and their implications in disease management as well as transmission control are highlighted. […] Besides respiratory symptoms, gastrointestinal and atypical features such as chilblains, neurological symptoms and multisystem inflammation are also reported. […] There are anecdotal reports of using antiviral and immunomodulatory drugs, benefit of which needs to be confirmed in clinical trials. | 2020-08-11 |
| 32773414 | The characteristic clinical observations and outcomes of this disease (COVID-19) have been reported from different countries. […] This was a prospective, single-centre collection of data regarding epidemiological, demographic, clinical and laboratory parameters, management and outcome of COVID-19 patients admitted in a tertiary care facility in north India. […] A significant proportion of patients had no symptoms (n=64; 44.4%); among the symptomatic, cough (34.7%) was the most common symptom followed by fever (17.4%) and nasal symptoms (2.15%). | 2020-08-11 |
| 32773471 | Prospective observational single-center cohort study of adult PLWH reporting symptoms of COVID-19. […] We assessed clinical characteristics, risk factors for COVID-19 diagnosis and severity, and standardized incidence rate ratio for COVID-19 cases in PLWH cohort and in Barcelona. […] Cough (87%) and fever (82%) were the most common symptoms. […] Clinical presentation, severity rate, and mortality were not dependent on any HIV-related or antiretroviral-related factor. | 2020-08-11 |
| 32773511 | Clinical-demographic data of the patients, indications, type of endoscopy, endoscopic findings (subtyped in major and minor), finding rates (major and minor) and diagnostic yields (major findings) have been analyzed and compared to the endoscopic procedures performed in March 2019. […] All the patients were recalled and neither cases of onset of Covid-19 like symptoms nor positive nasopharyngeal swabs PCR have been evidenced. | 2020-08-11 |
| 32773584 | Therefore, in this mini-review article, we aimed to summarize the current and emerging tools, focusing on diagnostic power of different clinical sampling and specimens. | 2020-08-11 |
| 32773613 | Given the growing body of critical care clinical research publications, core outcome sets (COSs) are important to help mitigate heterogeneity in outcomes assessed and measurement instruments used, and have potential to reduce research waste. | 2020-08-11 |
| 32773656 | No respiratory symptoms were identified, but both developed diarrhea, one probably secondary to lopinavir/ritonavir. | 2020-08-11 |
| 32773657 | Children <5 years who presented with ≥2 symptoms consistent with an acute respiratory tract infection were eligible for enrollment. […] HCoVs were detected in ~7% of outpatient Ecuadorean children <5 years of age with symptoms of acute respiratory tract infection. | 2020-08-11 |
| 32773661 | We report a 20-year-old female with SARS-CoV-2 encephalitis who presented with 4 days of upper respiratory symptoms, fevers and sudden acute altered mental status. | 2020-08-11 |
| 32773818 | Its common symptoms are highly similar to those of other viruses, such as fever, cough and dyspnea. […] This article reports the clinical features and therapeutic course of novel coronavirus infection in a patient after renal transplantation. […] The patient’s symptoms (such as fever, chills, dry cough, muscle aches), laboratory tests (such as decreased white blood cell count, elevated liver enzymes and D-dimer, positive viral nucleic acid test), and chest CT (multiple left lower lung plaque ground glass shadow) were similar to those of non-transplanted novel coronavirus pneumonia patients. | 2020-08-11 |
| 32773869 | Half of the respondents (52.1%) were preoccupied with the idea of contracting COVID-19 and one-fifth (21.1%) of the respondents were repeatedly thinking of getting themselves tested for the presence of COVID-19 despite having no symptoms. | 2020-08-11 |
| 32773996 | In most critical cases, symptoms can escalate into acute respiratory distress syndrome accompanied by a runaway inflammatory cytokine response and multiorgan failure. […] This has led to the prompt development of clinical patient risk stratification tools to aid in determining the need for testing, isolation, monitoring, ventilator support, and disposition. […] As the race to develop an effective vaccine intensifies, several clinical trials of antivirals and immune modulators are underway, though no reliable COVID-19-specific therapeutics (inclusive of some potentially effective single and multi-drug regimens) have been identified as of yet. | 2020-08-11 |
| 32774007 | Amidst COVID-19 pandemic, there is a need to change in imaging algorithm, for various clinical conditions taking care of the exposure risk to patients and healthcare workers and to handle the volume of diagnostic and intervention work. […] Radiology preparedness is to set the workflow protocols and policies applicable to radiology investigations for different clinical conditions, which will help to attain these objectives. | 2020-08-11 |
| 32774011 | The conventional exam pattern involved clinical case presentations and required resident interaction with a number of patients. […] In order to replicate the conventional exam case-scenarios, clinical cases were prepared in a digital presentation format. | 2020-08-11 |
| 32774118 | Infection causes a clinical syndrome encompassing a wide range of clinical features, from asymptomatic or oligosymptomatic course to acute respiratory distress and death. | 2020-08-11 |
| 32774178 | The presence of COVID-19 was manifested by several symptoms, ranging from asymptomatic/mild symptoms to severe illness and death. […] To quickly diagnose and control such a highly infectious disease, suspicious individuals were isolated and diagnostic/treatment procedures were developed through patients’ epidemiological and clinical data. […] At present, COVID-19 is managed by available antiviral drugs to improve the symptoms, and in severe cases, supportive care including oxygen and mechanical ventilation is used for infected patients. | 2020-08-11 |
| 32774232 | This virus can cause progressive respiratory symptoms and severe diseases such as organ failure and death. […] Angiotensin converting enzyme II is an entry receptor for SARS-CoV-2, which is highly expressed in the kidney, so some patients had symptoms of kidney damage. | 2020-08-11 |
| 32774271 | Cytokine storm is suggested as one of underlying mechanisms for the rapid clinical decline. […] This case report describes the presentation and clinical course of a cancer survivor who became critically ill and required mechanical ventilation. | 2020-08-11 |
| 32774508 | There is no randomized clinical trial that can prove so far the efficacy of this medication, and few studies have evaluated adverse events potentially linked to their use in patients with COVID-19. | 2020-08-11 |
| 32774577 | Angiographic aspiration thrombectomy resulted in a significant reduction of thrombus material and improved flow in the pulmonary arteries and immediate marked clinical improvement and subsequent normalization of functional echocardiographic parameters. | 2020-08-11 |
| 32774640 | Sickle cell disease management is the major contributor of financial burden on the government. | 2020-08-11 |
| 32774659 | Although pregnant women are not necessarily more susceptible to infection by the virus, changes to their immune system in pregnancy may be associated with more severe symptoms. | 2020-08-11 |
| 32774998 | We propose the use of CHM treatment principles for clinical practice, based on four main stages of COVID-19 infection: early, intermediate, severe, and convalescence. | 2020-08-11 |
| 32775074 | At first, the typical signs and symptoms were what one would expect from a respiratory virus: cough, shortness of breath, and fever. […] However, as the disease became more prevalent, neurologic symptoms were reported such as headaches, hypogeusia, and hyposmia. | 2020-08-11 |
| 32775090 | There are now many publications about its etiology, epidemiology, investigations, and clinical presentation. […] There are many guidelines, clinical trials, and information on various media platforms that hinder the tracking of developments in this rapidly evolving situation. | 2020-08-11 |
| 32775112 | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been initially defined as a disease of the respiratory tract; however, with the increasing number of patients and announcing that the virus became a pandemic, new systemic clinical manifestations are observed, including dermatological manifestations. […] This review article aims to evaluate the medical literature and explore the dermatological clinical manifestations in patients with SARS-CoV-2. […] Searching terms included were a combination of “dermatological” OR “skin” AND “symptoms” OR “manifestations” AND “SARS-CoV-2”. […] The following step was filtering the results to include only original research studies investigating the different types of skin and dermatological clinical manifestations in patients with SARS-CoV-2. […] Altogether, seven studies were identified as eligible, covering 555 patients with SARS-CoV-2 who had dermatological symptoms. | 2020-08-11 |
| 32775188 | The diagnosis of Coronavirus Disease 2019 (COVID-19) is based on the identification of common symptoms such as fever, tiredness and dry cough. […] Anosmia and ageusia are also in fact symptoms of the infection with the new coronavirus and recently were considered as symptoms by the World Health Organization. […] The patient, 31-year-old, reported olfactory and gustatory dysfunctions as initial symptoms of mild-to-moderate form of the COVID-19. | 2020-08-11 |
| 32775219 | The clinical and epidemiological characteristics of COVID-19 suggest this is too late. | 2020-08-11 |
| 32775243 | Special attention should be paid to students with insufficient clinical experience. | 2020-08-11 |
| 32775377 | Fever and pulmonary symptoms have been noticed as major and early signs of infection, whereas gastrointestinal symptoms were also observed in a significant portion of patients. […] The clinical investigation of disease onset was underestimated, especially due to the neglection of cases presenting with gastrointestinal symptoms. […] To characterize the clinical features of coronavirus-infected patients with gastrointestinal symptoms as initial symptoms. […] According to their initial symptoms, these patients were classified into two groups. […] Patients in group one presented with pulmonary symptoms (PS) as initial symptoms, and group two presented with gastrointestinal symptoms (GS). […] Epidemiological, demographic, clinical, laboratory, and treatment data were collected for analysis. […] COVID-19 patients presenting with gastrointestinal symptoms as initial symptoms need more days of viral shedding and hospitalization than the patients presenting with pulmonary symptoms. | 2020-08-11 |
| 32775378 | Optimizing the diagnosis process, shortening the diagnosis time, and constructing teams of clinical experts facilitated the provision of “one team of medical experts for each patient” treatment for severe patients, which significantly improved the recovery rate and reduced the infection fatality rate. | 2020-08-11 |
| 32775781 | We retrospectively reviewed the CBCT scans of an initially asymptomatic patient undergoing image-guided RT for breast cancer who developed COVID-19 symptoms during the second week of RT. | 2020-08-11 |
| 32775785 | We describe the institutional guidelines of a major tertiary cancer center with regard to using hypofractionated radiation regimens to treat glioblastoma as a measure to minimize exposure to coronavirus disease 2019 (COVID-19) while not sacrificing clinical outcomes. | 2020-08-11 |
| 32775789 | However, the specialty of radiation oncology is unique in its use of computed tomography (CT) imaging for image guidance, and these CT studies have the potential to identify patients with COVID-19 even before they develop symptoms. | 2020-08-11 |
| 32775790 | A critical review was performed of the articles that described clinical outcomes of single-fraction SBRT for treatment of primary extracranial cancers and oligometastatic extraspinal disease. | 2020-08-11 |
| 32775814 | Clinical information was extracted and examined from 20 cohorts that met inclusion criteria, covering 13,137 mostly hospitalized patients confirmed to have COVID-19. | 2020-08-11 |
| 32775837 | We compared the clinical manifestation and immune profiles among different patient groups with healthy individuals. […] Except for 3 patients who were admitted to the intensive care unit for a severe condition (8.11%), including 2 who died, most COVID-19 diagnosed patients presented mild or nonrespiratory symptoms. […] Most HD patients with COVID-19 exhibited mild clinical symptoms and did not progress to severe pneumonia, likely due to the impaired cellular immune function and incapability of mounting cytokine storm. | 2020-08-11 |
| 32775943 | The explicit lack of standardization of evidence-based maternity care, whether expressed in clinical protocols or institutional policy, has disproportionately impacted marginalized communities. | 2020-08-11 |
| 32775986 | Clinical features, management, and outcomes were recorded. […] Most common initial symptoms included fever, cough, or dyspnea. 18 (82%) patients required hospitalization. […] The clinical presentation of COVID-19 infection was similar to that reported in the general population. | 2020-08-11 |
| 32776115 | Multiple studies in Europe have implicated anosmia and ageusia as symptoms associated with COVID-19, and subsequently, anosmia and ageusia have been added to Centers for Disease Control and Prevention screening guidelines as well. […] There should be a higher index of suspicion when evaluating a patient with high-risk activities, travel, and atypical symptoms. | 2020-08-11 |
| 32776161 | The subjects were 35 patients with COVID-19, and clinical characteristics were retrospectively analyzed. | 2020-08-11 |
| 32776197 | We reviewed medical records of 373 consecutive adult patients who were hospitalized with COVID-19 between February 22 and May 15, 2020. | 2020-08-11 |
| 32776309 | We aimed to evaluate the epidemiological and clinical characteristics of newborns born to women infected with COVID-19. | 2020-08-11 |
| 32776354 | COVID-19, the illness caused by SARS-CoV-2, has a wide-ranging clinical spectrum that, in the worst-case scenario, involves a rapid progression to severe acute respiratory syndrome and death. | 2020-08-11 |
| 32776534 | To compare the rate of clinical improvement between those who started LPV/ritonavir (LPV/r)+HCQ within 5 days of symptom onset (early treatment, ET) and those who started later (delayed treatment, DT). […] The rate of clinical improvement increased over time to 73.3% on day 30, without any significant difference between the two groups (Gray’s test P = .213). […] After adjusting for potentially relevant clinical variables, there was no significant association between the timing of the start of treatment and the probability of 30-day mortality (adjusted odds ratio [aOR] ET vs DT = 1.45, 95% confidence interval 0.50-4.19). […] The timing of the start of LPV/r + HCQ treatment does not seem to affect the clinical course of hospitalized patients with COVID-19. | 2020-08-11 |
| 32776573 | However, the evidence is of low quality (mortality reduction, and viral clearance), and very low quality (clinical improvement). […] CPT may be beneficial for reducing mortality, viral shedding and improving clinical conditions in COVID-19 patients. | 2020-08-11 |
| 32776601 | Although up to 72.7% remained active during confinement, 65.7% perceived a worsening of their symptoms. […] More than half experienced worsening of their symptoms during confinement. | 2020-08-11 |
| 32776614 | The study included 359 patients diagnosed with COVID-19 and assessed by clinical evaluation, nasopharyngeal polymerase chain reaction, and lung computed tomography. | 2020-08-11 |
| 32776761 | Most children are asymptomatic or exhibit mild symptoms from COVID-19 infection. […] PIMS-TS can also share clinical features with other conditions including toxic shock syndrome, septic shock and Kawasaki disease. | 2020-08-11 |
| 32776832 | CO-RADS categorization of the level of COVID-19 suspicion might improve diagnostic performance.PurposeTo investigate the value of chest CT with CO-RADS classification to screen for asymptomatic SARS-CoV-2 infections and to determine its diagnostic performance in individuals with COVID-19 symptoms during the exponential phase of viral spread.Materials and MethodsIn this secondary analysis of a prospective trial (Clinical Trial Number: IRB B1172020000008), from March 2020 to April 2020, we performed parallel SARS-CoV-2 PCR and CT with categorization of COVID-19 suspicion by CO-RADS, for individuals with COVID-19 symptoms and controls without COVID-19 symptoms admitted to the hospital for medical urgencies unrelated to COVID-19. […] AUC were calculated in symptomatic versus asymptomatic individuals to predict positive SARS-CoV-2 positive PCR and likelihood ratios for each CO-RADS score were used for rational selection of diagnostic thresholds.Results859 individuals (median 70 years, IQR 52-81, 443 men) with COVID-19 symptoms and 1138 controls (median 68 years, IQR 52-81, 588 men) were evaluated. | 2020-08-11 |
| 32776871 | The novel coronavirus (COVID-19) pandemic has forced program directors of sleep medicine fellowship programs, and other clinical training programs, to immediately transition longstanding face-to-face clinical and didactic instruction to virtual formats. […] Clinical educators must also understand how to consider and maintain equity while implementing distance learning strategies. […] These resources are listed by topic domain to provide guidance on how to effectively implement distance learning strategies into a clinical training program. […] Links to helpful resources are provided for each of the following topics: Virtual Clinical Care, Didactic Delivery in a Virtual Clinical Learning Environment, Generating Scholarship via Distance Learning, Well-being in the Setting of Distance Learning, Virtual Interviews, and Equity in a Virtual Clinical Learning Environment. […] Clinical training programs, including sleep medicine fellowships, can utilize virtual and distance learning methodologies to deliver, and even enhance, currently existing curricula. | 2020-08-11 |
| 32776899 | Fewer than 10% of videos mentioned how the virus is transmitted, symptoms, and prevention. […] WHO videos more often focused on viral transmission and symptoms but covered these topics in fewer than 10% of the videos. […] Conclusions Although research suggests that cases of COVID-19 may be less severe in those under 18 years of age, social distancing remains paramount due to the possibility of transmission even in those with minimal or no symptoms. | 2020-08-11 |
| 32776905 | Patients with a severe phenotype of disease and those who died from the disease have shown hyperinflammation and were more likely to develop neurological manifestations, linking the clinical disease with neuroimmunological features. | 2020-08-11 |
| 32777008 | Responses to 3 clinical scenarios-refraction request, cataract evaluation, and symptoms of a posterior vitreous detachment-were compared regionally and between private and university centers. […] Private practices had shorter times to next available appointment for cataract extraction and were more likely to evaluate posterior vitreous detachment symptoms. | 2020-08-11 |
| 32777031 | However, the clinical performance of many of these is still insufficiently described. | 2020-08-11 |
| 32777050 | On the day of sampling, a health questionnaire was answered, reporting symptoms on the same day and in the previous fourteen days. | 2020-08-11 |
| 32777153 | Risk factors for death and acute respiratory distress syndrome (ARDS) were investigated, and clinical and laboratory data were analyzed. | 2020-08-11 |
| 32777170 | Multiple clinical trials are currently being conducted, which may identify more drugs that can lower mortality, morbidity, and burden on the society. […] These findings are intriguing, although there is no clinical evidence for a protective effect to reduce the likelihood of severe COVID-19 or to treat the immune storm or acute respiratory distress syndrome (ARDS) that often causes severe morbidity. […] Here, we review the putative link between COVID-19 and cyclosporine, while we await more robust clinical data. | 2020-08-11 |
| 32777178 | We conclude that analyzing the kinetics of nonspecific and SARS-CoV-2-reactive cellular and humoral immunity can facilitate the clinical decision on immunosuppression adjustment and allow successful outcome as demonstrated in the current clinical case. | 2020-08-11 |
| 32777212 | Several clinical studies are being performed to test possible drugs in response to the COVID-19 outbreak; however, there is still no treatment that is completely effective. | 2020-08-11 |
| 32777268 | Platypnea-orthodeoxia syndrome (POS) is a rare clinical syndrome characterized by orthostatic oxygen desaturation and positional dyspnea from supine to an upright position. | 2020-08-11 |
| 32777301 | Availability of point of care devices do not conform to sensitivity and specificity in comparison to the conventional methods due to lack of clinical investigations. […] Pivotal aim of molecular and serological research is the development of detection methods that can support the clinical decision making of patients suspected with SARS-CoV-2. | 2020-08-11 |
| 32777401 | All other specialties have been compelled to suspend or reduce clinical and elective surgical activities. | 2020-08-11 |
| 32777537 | The clinical trial landscape for Coronavirus 2019 (COVID-19) is radically different from that of previous epidemics. […] Compared with H1N1, Ebola, and Zika, COVID-19 had an order of magnitude more clinical trials within the first 3 months following the declaration of a Public Health Emergency of International Concern (PHEIC). […] Thus, an international coordination mechanism for clinical trials could be valuable in this and other situations. | 2020-08-11 |
| 32777550 | Data on the clinical characteristics of patients with inflammatory bowel diseases (IBDs) with coronavirus disease 2019 (COVID-19) are scarce. […] The aim of our systematic review was to investigate symptoms and diagnostic-therapeutic management of IBD patients with COVID-19. […] We searched PubMed, Embase, Web of Science, and MedRxiv up to July 29, 2020, to identify all studies reporting clinical information on adult and pediatric IBD patients with confirmed COVID-19. […] The most common symptoms were fever (48.3%), cough (46.5%), and diarrhea (20.5%), and a COVID-19 diagnosis was achieved mainly through polymerase chain reaction analysis of nasopharyngeal swabs (94.4%) and chest computed tomography scans (38.9%). | 2020-08-11 |
| 32777604 | Anxiety and depression symptoms in pregnancy typically affect between 10 and 25% of pregnant individuals. […] Elevated symptoms of depression and anxiety are associated with increased risk of preterm birth, postpartum depression, and behavioural difficulties in children. […] We assessed symptoms of anxiety and depression among pregnant individuals during the current COVID-19 pandemic and determined factors that were associated with psychological distress. 1987 pregnant participants in Canada were surveyed in April 2020. […] We found substantially elevated anxiety and depression symptoms compared to similar pre-pandemic pregnancy cohorts, with 37% reporting clinically relevant symptoms of depression and 57% reporting clinically relevant symptoms of anxiety. […] Higher symptoms of depression and anxiety were associated with more concern about threats of COVID-19 to the life of the mother and baby, as well as concerns about not getting the necessary prenatal care, relationship strain, and social isolation due to the COVID-19 pandemic. […] Higher levels of perceived social support and support effectiveness, as well as more physical activity, were associated with lower psychological symptoms. […] This study shows concerningly elevated symptoms of anxiety and depression among pregnant individuals during the COVID-19 pandemic, that may have long-term impacts on their children. […] Potential protective factors include increased social support and exercise, as these were associated with lower symptoms and thus may help mitigate long-term negative outcomes. | 2020-08-11 |
| 32777639 | Demographic and clinical data of all confirmed cases with COVID-19 on admission to Tongji Hospital from January 27 to March 5, 2020, were collected and analyzed, and coagulation function parameters were described and compared between patients with severe infection and those with non-severe infection. | 2020-08-11 |
| 32777726 | The rapid and accurate monitoring and determination of pathogens are of great significance to clinical diagnosis, food safety and environmental evaluation. | 2020-08-11 |
| 32777745 | Patients showed a mild clinical course of SARS-CoV-2 related pneumonia without complications or sequelae. | 2020-08-11 |
| 32777758 | In a pandemic, RRT practice is likely to be determined by the number of patients, availability of machines, consumables and staff, clinical expertise, and acceptable alternatives. | 2020-08-11 |
| 32777761 | Several studies reported the analytical and/ or clinical evaluation of these molecular assays, however differences in the viral materials used for these evaluations complicated direct comparison of their analytical performance. […] The comparison was performed utilizing a single positive clinical specimen that was serially diluted in viral transport media and quantified by the EUA approved SARS-CoV-2 droplet digital PCR (ddPCR) assay. | 2020-08-11 |
| 32777762 | The persistence of SARS-CoV-2 RNA shedding in the context of clinical features and comorbidities is understudied. […] The most common symptoms at diagnosis were cough, myalgia, dyspnea, fever and chills. […] The median time from symptom onset to CVS was 23 days, and did not differ by symptoms. […] Cough and fever were associated with a positive PCR test if tested within 2 weeks of symptoms (P < 0.05). […] Patients with asthma or immunosuppression were less likely to achieve CVS if tested 3 weeks into symptoms (P < 0.04). | 2020-08-11 |
| 32777798 | Their clinical and laboratory characteristics were summarised. […] All patients had significant risk factors and ongoing or evolving symptoms, which warranted repeat testing. | 2020-08-11 |
| 32777861 | The aim of this study was to investigate the prevalence of previously undiagnosed SARS-CoV-2 infection in health professionals from two tertiary-level maternity units in London, UK, and to determine associations between healthcare workers’ characteristics, reported symptoms and serological evidence of prior SARS-CoV-2 infection. | 2020-08-11 |
| 32778005 | Portable technology has become acutely important with the coronavirus disease 2019 pandemic and the conversion of in-person clinical evaluations to remote telemedicine encounters. | 2020-08-12 |
| 32778033 | The new pandemic Coronavirus Disease 2019 (COVID-19) causes a wide range of clinical consequences, from asymptomatic infection to acute respiratory failure and it is very heterogeneous. | 2020-08-12 |
| 32778136 | Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. | 2020-08-12 |
| 32778180 | In total, 88% of the patients experienced symptoms of high fever, 68% suffered from dry cough and 7.1% patients were asymptomatic. | 2020-08-12 |
| 32778225 | These results support the further evaluation of BBIBP-CorV in a clinical trial. | 2020-08-12 |
| 32778421 | Since the beginning of this outbreak, several interesting papers on SARS-CoV-2 and COVID-19 have been published to report on the phylogenetic evolution, epidemiology, pathogenesis, transmission as well as clinical characteristics of COVID-19 and possible treatments agents. | 2020-08-12 |
| 32778470 | This pandemic has caused prosthodontics units to suspend their clinical and educational operations in academia. […] The purpose of this article was to review the experiences from the Department of Prosthodontics, Wuhan University School and Hospital of Stomatology (DP-WHUSHS), during the COVID-19 outbreak and the protocols DP-WHUSHS used to resume clinical activities after the outbreak. […] During the COVID-19 outbreak period, clinical care was provided for patients with dental emergencies by using enhanced grade 2 or grade 3 personal protective equipment (PPE). […] Various factors were considered before clinical activities resumed after the outbreak subsided. […] New infection control and clinical operation protocols were developed to minimize the health-care-associated infection of airborne transmission diseases. […] Multifactorial considerations for work resumption after the outbreak included facility preparation and management, training for employees, and clinical operation management. | 2020-08-12 |
| 32778478 | After obtaining IRB approval we reviewed the medical records of 214 patients who underwent image-guided transperineal fusion biopsy of the prostate biopsy between 2017 and 2019. | 2020-08-12 |
| 32778554 | Preparing for any “second wave” requires strategies to educate and reassure parents about timely emergency department attendance for non-COVID-19 symptoms. | 2020-08-12 |
| 32778622 | Last, tertiary prevention propose to hamper the progress of clinical disease and prevent more severe complications of the disease, for examples cardiac rehabilitation, or medications for prevent chronic kidney disease in patients with diabetes or hypertension. | 2020-08-12 |
| 32778630 | During the pandemic, a suspicion of COVID-19 infection could be found on patients presented with clinical symptoms of COVID-19. […] However, several new clinical symptoms of COVID-19 had also been reported recently. […] This caused difficulties to identify COVID-19 based on the clinical symptoms only. […] We report a family cluster of COVID-19 with different clinical manifestations to show a potential COVID-19 transmission in person who has no symptoms initially but may develop symptoms later as the incubation period varies from 5-14 days. […] This report describes the epidemiological, clinical, radiological, laboratory findings, and different clinical manifestation of a family cluster of COVID-19 case in Indonesia. | 2020-08-12 |
| 32778631 | Through randomized clinical trials, various drugs were known to have good responses in COVID-19 patients. […] Here, we reported a-49-year-old-woman that was confirmed for COVID-19 by clinical manifestation, radiology profile, high procalcitonin concentration, and positive polymerase chain reaction (PCR) test. […] The patient was treated with various antibiotics but showed a significant clinical improvement by administering moxifloxacin. | 2020-08-12 |
| 32778857 | Continuous progress in the information communication technology field and universal access to social communication platforms have allowed clinicians to creatively transcend some of the existing traditional barriers in clinical and technological workflows. | 2020-08-12 |
| 32778870 | Frailty was assessed at baseline, according to the Clinical Frailty Scale (CFS), where higher categories indicate worse frailty. | 2020-08-12 |
| 32778874 | To understand the pathogenetic behavior of 2019-nCoV, we compared gene expression datasets of viral infections closest to 2019-nCoV with four COVID-19 clinical presentations followed by functional enrichment of shared dysregulated genes. | 2020-08-12 |
| 32778886 | Clinical manifestations resolved and laboratory parameters improved with intravenous immunoglobulin and corticosteroids. | 2020-08-12 |
| 32778950 | Additionally, ongoing and discontinued clinical trials that have been carried out for validating probable treatments for COVID-19 are discussed. […] The review also elaborates the prospective approach and the possible advantages of using convalescent plasma and stem cells for the improvement of clinical symptoms and meeting the demand for an instantaneous cure. | 2020-08-12 |
| 32778962 | In the absence of a vaccine, the goal is to target the viral life cycle and alleviate the lung-damaging symptoms of infection, which can be life-threatening. […] There are numerous protein kinases associated with these processes that can be inhibited by FDA-approved drugs, the repurposing of which presents an alluring option as they have been thoroughly vetted for safety and are more readily available for treatment of patients and testing in clinical trials. […] Certain agents are projected to be dual-purpose drugs in terms of antiviral activity and alleviation of disease symptoms, however drug combination is also an option for inhibitors with optimal pharmacokinetic properties that allow safe and efficacious co-administration with other drugs, such as antiviral agents, IL-6 blocking agents, or other kinase inhibitors. | 2020-08-12 |
| 32778985 | We report five cases of COVID-19 presenting to the ER with acute neurological symptoms, over the course of 1 month. | 2020-08-12 |
| 32779091 | The aim of the present manuscript is to review the main relevant mechanisms possibly contributing to worsen the clinical course of COVID-19 in T2D. […] Further studies are needed to clarify whether medications normally used for managing T2D and its associated comorbidities could have a protective or detrimental effect on COVID-19 clinical course. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779108 | A woman in her forties with asthma and COPD was admitted to a general medical floor with respiratory symptoms, body aches, and anosmia. […] At follow-up 1 month later, her symptoms were improved and still relieved by gabapentin. | 2020-08-12 |
| 32779163 | An extremely important issue is the need to register all the cases of COVID-19 affected women and the course of these pregnancies to local, regional, or international registries, which will be helpful to answer many clinical and scientific questions and to create guidelines ensuring an adequate level of care for women affected by COVID-19 infection during pregnancy, delivery and during postpartum period, as well as their newborns. | 2020-08-12 |
| 32779188 | The balance between avoiding severe acute respiratory syndrome coronavirus-2 contagion and reducing wider clinical risk is unclear for gestational diabetes mellitus (GDM) testing. | 2020-08-12 |
| 32779201 | Immunomodulatory biological therapies are being evaluated in clinical trials for the management of the systemic inflammatory response and pulmonary complications in patients with advanced stages of COVID-19. […] In this review, we summarize the clinical pharmacology considerations in the development of immunomodulatory therapeutic proteins for mitigating the heightened inflammatory response identified in COVID-19. | 2020-08-12 |
| 32779280 | Using a consensus, we defined seven clinical patterns. | 2020-08-12 |
| 32779326 | The first clinical trials have been testing repurposed drugs that show promising anti-SARS-CoV-2 effects in cultured cells. […] Although more than 2400 clinical trials are already under way, the actual number of tested compounds is still limited to approximately 20, alone or in combination. […] Moreover, the observed discrepancies might also result from differences in the clinical inclusion criteria, including the possibility of early treatment that may be essential for therapy efficacy in patients with Covid-19. […] Importantly, efforts should also be made to test new compounds with a documented MoA against SARS-CoV-2 in clinical trials. | 2020-08-12 |
| 32779341 | Several antiviral agents and vaccines are in clinical trials, and drug repurposings as immediate and alternative choices are also under consideration. | 2020-08-12 |
| 32779342 | Thus, we must keep in mind that all medical personnel must understand and maintain standard precautions in their clinical and laboratory practices. | 2020-08-12 |
| 32779447 | A great record was also observed in Wenzhou for the clinical management of COVID-19 patients, leading to one of the lowest death rates in China. […] Researchers and clinical specialists proposed and formulated combined approaches such as computerized tomography (CT)- scans and molecular assays, as well as using both allopathic and traditional medications to mitigate its effects. […] Iranian and Chinese specialists and scientists had a communication in clinical, molecular and pharmaceutical aspects of COVID-19. | 2020-08-12 |
| 32779465 | This paper describes possible clinical ocular manifestations of novel coronavirus infection COVID-19. […] Two clinical cases of conjunctivitis are examined. | 2020-08-12 |
| 32779481 | We present the case of a renal transplant patient who was infected with COVID-19 through community spread and presented with fever and gastrointestinal symptoms. | 2020-08-12 |
| 32779603 | Recently, neurological symptoms associated with COVID-19 have been shown to be not uncommon, with headaches receiving attention as one of the main neurological symptoms. […] The frequency of headaches associated with COVID-19 ranged from 5.6% to 70.3%, based on 21 clinical studies and 8 meta-analyses. | 2020-08-12 |
| 32779728 | Clinical equipoise on the use of corticosteroids for COVID-19 exists. […] The COVID STEROID trial is an international, randomised, stratified, blinded clinical trial. | 2020-08-12 |
| 32779733 | There are two distinctive acral manifestations of COVID-19 embodying disparate clinical phenotypes: one is perniosis occurring in mildly symptomatic patients, typically children; the second is the thrombotic retiform purpura of critically ill COVID19 adults. | 2020-08-12 |
| 32779736 | In all likelihood, the COVID-19 pandemic will continue to have a major impact on the practice of dentistry, not only in clinical practice but also in education. | 2020-08-12 |
| 32779744 | We conducted a retrospective analysis to explore the clinical characteristics of COVID-19 patients at different infection stages and to characterize the characteristics of specific serum antibodies at each stage. […] These data will provide a theoretical basis for clinical diagnosis and treatment. | 2020-08-12 |
| 32779755 | While studies are mixed on this topic, the therapeutic effect of HCQ or CQ still need more valid clinical evidence. […] The demographic, treatment, laboratory parameters of C-reactive protein (CRP) and interleukin-6 (IL-6) before and after HCQ therapy and clinical outcome in the 30 COVID-19 patients were assessed. | 2020-08-12 |
| 32779760 | In order to report the clinical characteristics and potential risk factors of COVID-19 Patients in Wuhan Stadium Cabin Hospital in Hubei Province. […] The main clinical symptoms of moderate COVID-19 were fever, cough and dyspnea, hypertension, diabetes and coronary heart diseases were the main comorbidities both in transferred and stable patients. 26 patients (4.55%) of mild and moderate patients had disease aggravation, and most of which occurred between 36 hours to 48 hours after admission. | 2020-08-12 |
| 32779768 | He had no past medical history (no chronic diseases or medication) or any symptoms of COVID-19; however, his brother reported that his roomate was diagnosed with COVID-19 one day prior and went to a protective isolation institution. | 2020-08-12 |
| 32779772 | Using derivatives of care from our clinical workflow, we compared traditional and unextracted CDC methodologies. | 2020-08-12 |
| 32779783 | The clinical picture of the coronavirus 2 (SARS-CoV-2)/COVID-19-related acute respiratory syndrome is often associated with a coagulopathy. | 2020-08-12 |
| 32779817 | The study’s object is to identify clinical and histopathological findings of cutaneous manifestations of COVID19 patients. | 2020-08-12 |
| 32779820 | In this study, we aimed to conduct a systematic review on COVID-19 clinical manifestations and treatment strategies in SOT recipients. […] Fever and Cough were the most reported clinical presentations. […] Patients’ demographics, signs, symptoms, and radiographic findings in SOT recipients are almost similar to the general population. […] However, gastrointestinal symptoms appear to be more common. | 2020-08-12 |
| 32779822 | Both clinical features and screening results including chest computerized tomography (CT); nucleic acid testing of nasopharyngeal, oropharyngeal or anal swabs; and quantitative antibodies (IgM and IgG) detecting of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) of these patients were described. […] For patients presenting suspicious symptoms, comprehensive examinations should be carried out. | 2020-08-12 |
| 32779824 | Both aerosolized antiviral therapy and oral intake of volatile molecules are briefly reviewed, and an evaluation of 1,8-cineole is provided in view of a possible clinical use and also for asymptomatic COVID-19. | 2020-08-12 |
| 32779828 | In our cohort, 50% of patients who ended up hospitalized only returned to the ED for incidental finding of low home SpO2 without worsening of symptoms. […] Half of patients who ended up hospitalized had SpO2 <92% without worsening symptoms. | 2020-08-12 |
| 32779838 | We analyzed basic demographic, clinical, and laboratory data to understand the relationship between lymphocytopenia at the time of hospital admission and clinical outcomes. […] This evidence supports the hypothesis that lymphocytopenia can be an early, useful, and easily obtained, prognostic factor in determining the clinical course and disease severity of a patient admitted to the hospital for Covid-19. | 2020-08-12 |
| 32779860 | To retrospectively analyze epidemiological, clinical and hematological characteristics of COVID-19 patients. […] The demographic, symptoms, and physiological parameters of 88 patients were collected and analyzed. | 2020-08-12 |
| 32779878 | So far, no specific antiviral therapeutic agent has been demonstrated to be effective for COVID-19; therefore, the clinical management is largely supportive and depends on the patients’ immune response leading to a cytokine storm followed by lung edema, dysfunction of air exchange, and ARDS, which could lead to multiorgan failure and death. […] Given that human mesenchymal stem cells (MSCs) from various tissue sources have revealed successful clinical outcomes in many immunocompromised disorders by inhibiting the overactivation of the immune system and promoting endogenous repair by improving the microenvironment, there is a growing demand for MSC infusions in patients with COVID-19-related ARDS in the ICU. | 2020-08-12 |
| 32779925 | Data were collected on diagnostic status (COVID-19: confirmed/excluded (using the RT-PCR test)), symptomatology (typical/atypical and other symptoms, body temperature and oxygen saturation) and, in the case of confirmed COVID-19, on disease course (recovered/clinically improved/deteriorated, deceased). […] Among patients with confirmed COVID-19, 65% had coughs, 70% had fever, 33% had shortness of breath, 28% had delirium/confusion and 10% had a sore throat; in patients in whom COVID-19 was excluded these symptoms were experienced in 70%, 47%, 45%, 26% and 13% of patients, respectively. | 2020-08-12 |
| 32779934 | We therefore recommend to consider VTE in COVID-19 patients with a sudden clinical deterioration such as hypotension, tachycardia, unexplained hypoxaemia or insufficient clinical improvement and to perform CT-angiography if indicated. | 2020-08-12 |
| 32779974 | After significant restrictions initially due to the COVID-19 pandemic, otolaryngologists have begun resuming normal clinical practice. | 2020-08-12 |
| 32780011 | This was a retrospective review of medical records of patients seen in the Sleep and Circadian Clinic at Brigham Health during the immediate period of one month after the national lockdown was announced on March 15, 2020. | 2020-08-12 |
| 32780165 | Median time from disease onset (i.e., viral symptoms) to ICU admission was 8 (6-11) days (missing for three); 161 (42.5%) patients were admitted within a week of disease onset, 173 (45.6%) between 8 and 14 days, and 42 (11.1%) > 14 days after disease onset; day 28 mortality was 26.4% (22-31) and decreased as time from disease onset to ICU admission increased, from 37 to 21% and 12%, respectively. […] Therapeutic interventions against SARS-CoV-2 might impact different clinical endpoints according to time since disease onset. | 2020-08-12 |
| 32780184 | The Online Symposium covered a range of interesting and inspiring topics around the molecular and clinical pharmacology of histamine, with nine exciting presentations delivered by young and senior members of the Society across both days. | 2020-08-12 |
| 32780290 | • Microbial coinfection exacerbates the processes of the occurrence, development and prognosis of COVID-19, and the difficulties of clinical diagnosis and treatment. | 2020-08-12 |
| 32780294 | We sought to characterize high-risk adults’ knowledge of COVID-19 symptoms, prevention strategies, and prevention behaviors. […] Knowledge was assessed by asking participants to name three symptoms of COVID-19 and three actions to prevent infection. […] Most participants could identify three symptoms (71.0%) and three preventive actions (69.2%). […] Commonly reported symptoms included: fever (78.5%), cough (70.6%), and shortness of breath (45.2%); preventive actions included: washing hands (86.5%) and social distancing (86.2%). | 2020-08-12 |
| 32780299 | Recent clinical evidences suggest increased level of cytokines and chemokines targeting lung tissue as a prominent etiological factor. […] The preliminary studies have demonstrated the safety and efficacy of MSCs and exosomes in mitigating symptoms associated with COVID-19. […] However, more preclinical and clinical studies are warranted to understand their mechanism of action and further establish their safety and efficacy. | 2020-08-12 |
| 32780415 | Consequently, increased susceptibility to viral respiratory infections have been reported in COPD, often worsened by bacterial co-infections and leading to serious clinical outcomes. | 2020-08-12 |
| 32780518 | However, this was beyond our primary aim to audit the local clinical care pathway with regards to diagnosing and treating VDD in patients with COVID-19. | 2020-08-12 |
| 32780560 | This study aims to describe the knowledge and attitude of Jordanian parents regarding COVID-19 in children, including clinical signs of the disease, modes of transmission and protection measures. […] Information regarding the clinical signs of the disease, modes of transmission, protection measures against COVID-19 and satisfaction with governmental measures was collected. […] The findings indicate that the parents had a good understanding of the clinical signs, mode of transmission and protection measures and were satisfied with governmental measures. […] Many correctly stated that fever was a clinical sign, followed by cough (77%). […] In summary, we believe that the findings reported here are important for understanding the clinical characteristics and vertical transmission potential of COVID-19 infection in children, from the perspective of parents. | 2020-08-12 |
| 32780717 | We present a case of delayed clinical progression of COVID-19 associated respiratory failure on day 25 after initial symptom onset and, notably, after initial full resolution of symptoms and negative RT-PCR nasopharyngeal testing. […] The patient’s delayed presentation of exertional dyspnea and the utilization of specific characteristics of chest radiography in confirmation with laboratory cytokine measurement allowed for clinical re-categorization of the patient’s status to active COVID-19 clinical disease and changed acute management. […] COVID-19 positive patients should be advised to continue to monitor for respiratory deterioration for a greatly extended period of time, even if RT-PCR testing is negative and initial clinical symptoms have resolved. | 2020-08-12 |
| 32780765 | Demographic, clinical, social influencers of health, exposure risk, medical co-morbidities, vaccination history, presenting symptoms, medications, and laboratory values were collected on all patients, and considered in our model development. 4,536 patients tested positive for SARS-CoV-2 during the study period. | 2020-08-12 |
| 32780793 | There is limited information about the clinical course and viral load in asymptomatic patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] Attending health care personnel carefully identified patients’ symptoms during isolation. […] Of the 110 (36.3%) asymptomatic patients, 21 (19.1%) developed symptoms during isolation. | 2020-08-12 |
| 32780809 | Forty-six percent of HCs developed symptoms consistent with COVID-19 disease. | 2020-08-12 |
| 32780815 | Airborne and direct contact contamination are the major infection pathways of Sars-CoV-2 and it has been shown that virus spread can also happen in absence of clinical symptoms. | 2020-08-12 |
| 32780854 | We describe clinical, biochemical, and imaging features of 4 patients with SAT related to SARS-CoV-2 infection. […] Neck pain radiated to the jaw and palpitations were the main presenting symptoms and were associated with fever and asthenia. […] Symptoms disappeared a few days after commencement of treatment (prednisone in 3 patients and ibuprofen in 1). […] Two patients were euthyroid, whereas 2 were diagnosed with subclinical hypothyroidism. | 2020-08-12 |
| 32780961 | The knowledge of physicians regarding the clinical significance and intervention of 7 common potential DDIs during COVID-19 treatment was evaluated via an online survey. […] After the information brief, there were significant increases in the number of correct responses for both clinical significance and interventions (p < 0.0001). […] Physicians involved in the treatment of COVID-19 patients had more knowledge regarding clinical significance and appropriate management of potential DDIs than those not involved. | 2020-08-12 |
| 32781034 | To describe the clinical characteristics of children and adolescents admitted to intensive care with confirmed COVID-19. […] Demographic, clinical-epidemiological features, treatment, and outcomes were collected. […] Severe symptoms, gastrointestinal symptoms, and higher inflammatory markers were more frequent in multisystemic inflammatory syndrome. […] In Brazilian pediatric intensive care units, COVID-19 had low mortality, age less than 1 year was not associated with a worse prognosis, and patients with multisystemic inflammatory syndrome had more severe symptoms, higher inflammatory biomarkers, and a greater predominance of males, but only comorbidities and chronic diseases were independent predictors of severity. | 2020-08-12 |
| 32781230 | Globally, there has been a rapid proliferation of research studies and clinical trials assessing risks, infectivity and treatment. […] This review assesses the opportunities and challenges in the Middle East North Africa (MENA) region to engage in the conduct of high quality clinical trials during the Covid-19 pandemic. […] Opportunities are abundant for conducting clinical trials in MENA countries, including substantial cost savings, academic health centers, integrated health information systems, international accreditation, and international collaborations. […] Yet, the MENA region has missed out on opportunities to advance patient research during prior infectious disease outbreaks caused by the Severe Acute Respiratory Syndrome, Ebola, and the Middle East Respiratory Syndrome, as evidenced by the lack of concerted research and clinical trials from the region. […] Quality clinical research is critical during public health emergencies to identify treatments and solutions. […] The efficient conduct of clinical trials requires innovative strategies in research design, approval, and dissemination. | 2020-08-12 |
| 32781283 | This randomized controlled clinical trial evaluated the clinical efficacy and prognosis of Huoxiang Zhengqi dropping pills and Lianhua Qingwen granules in patients with COVID-19. […] A total of 283 patients participated in this clinical trial, and participants were randomly assigned to receive either 1) Huoxiang Zhengqi dropping pills and Lianhua Qingwen granules or 2) Linahua granules, both combined with western medicine, or 3) western medicine alone for 14 days. […] At the end of the trial, the improvement and resolution rates of clinical symptoms and the rate of patients who progressed to severe disease status were evaluated. […] After 14 days of treatment, there was no significant difference in the improvement rate of clinical symptoms among the three groups (P > 0.05). […] Among the 182 diagnosed patients who completed this clinical trial, 13 patients progressed to severe disease, including one case in the Huoxiang + Lianhua group (1.6 %), five cases in the Lianhua group (8.6 %), and seven cases in the western medicine group (11.1 %). […] The use of Huoxiang Zhengqi dropping pills and Lianhua Qingwen granules combined with western medicine may have clinical advantages for COVID-19 patients in improving clinical symptoms, reducing utilization rate of anti-infective drugs, and improving patient prognosis, which could pave the way for the use of complementary medicine in treating this infection. | 2020-08-12 |
| 32781456 | All but one had respiratory symptoms. […] None of the patients had a history or symptoms of urogenital disease. | 2020-08-12 |
| 32781471 | Nevertheless, based on clinical judgment, the planned median delay will not worsen the prognosis of the affected patients. | 2020-08-12 |
| 32781484 | Here we report the clinical course, detailed cerebrospinal fluid (CSF) profile including CSF/blood antibody status, and neurochemical parameters of a case with a typical clinical presentation of MFS after being tested positive for SARS-CoV-2 infection. | 2020-08-12 |
| 32781571 | Investigating the virology of COVID-19 and immunological pathways underlying its clinical manifestations will enable the identification and design of effective vaccines and potential therapies. | 2020-08-13 |
| 32781617 | In this review, we have systematically summarized the epidemiological studies, clinical features, biological properties, diagnostic methods, treatment modalities, and preventive measurements related to COVID-19. | 2020-08-13 |
| 32781623 | Intracranial hemorrhage has been observed in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19), but the clinical, imaging, and pathophysiological features of intracranial bleeding during COVID-19 infection remain poorly characterized. […] This study describes clinical and imaging characteristics of patients with COVID-19 infection who presented with intracranial bleeding in a European multicenter cohort. […] The clinical, laboratory, radiologic, and pathologic findings, therapy and outcomes in COVID-19 patients presenting with intracranial bleeding were analyzed. | 2020-08-13 |
| 32781796 | Both clinical and preclinical studies are examined, analyzing the effects of arginine supplementation in hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus. | 2020-08-13 |
| 32781984 | The clinical progress of patients hospitalized due to COVID-19 is often associated with severe pneumonia which may require intensive care, invasive ventilation, or extracorporeal membrane oxygenation (ECMO). | 2020-08-13 |
| 32782030 | Chemosensitive disturbances persisted in 7.2 per cent of patients 60 days after clinical onset. | 2020-08-13 |
| 32782040 | Approximately half of the participants were relieved of symptoms, and most of them were transferred to mobile cabin hospitals to continue isolation. […] Three participants with worsening symptoms were transferred to the designated hospitals. […] During a period of home isolation under the guidance of a doctor, individuals can comply with epidemic prevention measures and symptoms can be improved. | 2020-08-13 |
| 32782047 | The clinical laboratory center of Leishenshan Hospital (CLCLH) was constructed at the same time within 11 days to support the treatment of inpatients in Leishenshan Hospital and the testing of suspected patients from different fever clinics in Wuhan. | 2020-08-13 |
| 32782053 | According to the LDA analysis, the public was highly interested in topics such as COVID-19 prevention, infection symptoms, infection and coping measures, sources of transmission and treatments, community management, and work resumption. | 2020-08-13 |
| 32782108 | Two months afterward, a questionnaire was prepared regarding the preventive measures practiced by renal transplant recipients, and patients were asked whether they had any COVID-19 symptoms or had received a COVID-19 diagnosis. | 2020-08-13 |
| 32782109 | At the peak of the outbreak in Wuhan (January and February), there are two types of COVID-19 patients: laboratory confirmation and clinical diagnosis. […] This study aims to compare and analyze the clinical outcomes and characteristics of confirmed and clinically diagnosed COVID-19 patients to determine whether they are of the same type and require equal treatment. […] Demographic data, clinical characteristcs, laboratory results and prognostic information were collected by electronic medical record system and analyzed. […] There were no significant differences in clinical outcomes (mortality rate 39[22.54%] vs 7[33.33%], P=0.272) and hospital stay (19.00 vs 16.90 days, P=0.411) between the confirmed and clinically diagnosed group, and prognostic factors were similar between them. […] Laboratory-confirmed and clinically diagnosed COVID-19 patients are similar in clinical outcomes and most clinical characteristics. […] Age, AST, LDH, BUN, PT, D-D, IL6, white blood cell and neutrophil counts, T cell and T cell subset counts can efficiently predict clinical outcomes. | 2020-08-13 |
| 32782110 | Following data were collected including patient demographic information, medical history, clinical characteristics, laboratory data, therapeutic interventions during the hospitalization and clinical outcomes. | 2020-08-13 |
| 32782131 | Demographic and clinical data were obtained using chart abstraction from the electronic medical record. […] The most common clinical indications for TTE were concern for a major acute cardiovascular event (45.8%) and hemodynamic instability (29.2%). […] Clinical management was changed in eight individuals (24.2%) in whom TTE was ordered for concern for acute major cardiovascular events and three (14.3%) in whom TTE was ordered for hemodynamic evaluation. […] This study describes the clinical indications for use and diagnostic performance of TTE, as well as findings seen on TTE, in hospitalized patients with COVID-19. […] In appropriately selected patients, TTE can be an invaluable tool for guiding COVID-19 clinical management. | 2020-08-13 |
| 32782187 | Once healthcare professionals are using protective equipment, it is necessary to argue about the humanization of nursing caring in people suffering dying situation, who are infected with COVID-19, regarding a clinical case. | 2020-08-13 |
| 32782429 | Knowledge on COVID-19 symptoms was highest in this order: fever > dry cough > difficulty breathing > fatigue > headache with no significant differences between lecturers and students. | 2020-08-13 |
| 32782765 | In this truly unprecedented situation, the clinical management of neuromuscular patients during the COVID-19 epidemics - taking into account the related difficulties (patients who have suspended ERT, difficulty in contacting the doctors, etc.) - we propose to use a telemedicine device, i.e. the AIGkit application (AIGkit app), promoted and developed in 2018 by Fabrizio Seidita on behalf of the Italian Glycogenosis Association (AIG). | 2020-08-13 |
| 32782784 | We describe a 55-year-old woman with severe idiopathic pulmonary arterial hypertension (mean pulmonary artery pressure 71 mmHg, pulmonary vascular resistance 30 WU at diagnosis five months ago), who was diagnosed with SARS-CoV-2 infection (COVID-19) and experienced a relatively mild course with symptoms resembling a common cold. […] To date, information about the clinical course of COVID-19 in pre-existing pulmonary arterial hypertension is lacking, and it is thus unknown whether pulmonary arterial hypertension belongs to the risk factors of severe COVID-19 disease. | 2020-08-13 |
| 32782814 | We present the analysis of a COVID-19 outbreak in a hemodialysis center in Belgium and report the incidence, clinical course, and outcome of the disease. […] The incidence, clinical course, and outcome were reported. […] Eleven (28%) COVID-19-related deaths were recorded with a median time for onset of symptoms-to-death of 9 (IQR = 5-14) days. | 2020-08-13 |
| 32782815 | While primarily a respiratory disorder, it has also been shown to cause neurological symptoms, which can be a concern for Parkinson’s disease (PD) patients. […] The indirect effects of the pandemic are associated with the social distancing measures and disruptions in health care systems and PD clinical trials, which may negatively affect PD patients’ mental wellbeing and create barriers in controlling their PD symptoms. […] However, further research should be conducted to examine the applicability of telemedicine across the entire PD population, such as those with more severe symptoms living in less developed areas. | 2020-08-13 |
| 32782878 | There was no history of fever or respiratory symptoms. […] The patient had hypovolemic hyponatremia due to gastrointestinal (GI) losses and was managed with saline infusion for correction of hyponatremia with improvement in his clinical status. | 2020-08-13 |
| 32783040 | The symptoms of COVID-19 are more or less related to the nose and throat. […] Therefore, patients more often present to Ear Nose Throat (ENT) clinics with symptoms including cough, sore throat, fever and shortness of breath. | 2020-08-13 |
| 32783099 | We conducted a nation-wide survey of all heart transplant centers in Germany presenting the clinical characteristics of heart transplant recipients with COVID-19 during the first months of the pandemic in Germany. | 2020-08-13 |
| 32783196 | Some of these compounds are in advanced clinical trials. […] Noteworthy, some preliminary clinical results suggest an inverse relationship between endogenous H2 S levels and severity of COVID-19. | 2020-08-13 |
| 32783337 | Data collected from surgical audits; hospital databases and patient’s medical records were used to compare the first 7 weeks of our new service delivery (30 March to 17 May 2020) to the corresponding 7 weeks in 2019 (1 April 2019 to 19 May 2019). | 2020-08-13 |
| 32783494 | As a result, there remains much to be learned about mechanisms of neonatal infection including potential vertical transmission, best methods of testing, and the spectrum of clinical findings. […] This communication describes the epidemiology, diagnostic test results and clinical findings of neonatal COVID-19 during the pandemic in Iran. […] We analyzed obstetrical information, familial COVID-19 status, neonatal medical findings, perinatal complications, hospital readmissions, patterns of repeated testing, and clinical outcomes. […] Seven newborns (37%) were discharged from the hospital as healthy but required readmission for symptoms of COVID-19. […] There were 2 multifetal gestations - one set each of twins and triplets, each with disparate testing and clinical outcomes. […] These cases have notable variation in the epidemiology, clinical features, results of testing and clinical outcomes among the infected newborns. | 2020-08-14 |
| 32783500 | New concepts of nursing also emerged during their clinical care for COVID-19 patients. | 2020-08-14 |
| 32783610 | The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging from asymptomatic to fatal. […] Although the clinical and laboratory characteristics of COVID-19 patients have been well characterized, the pathophysiological mechanisms underlying disease severity and progression remain unclear. | 2020-08-14 |
| 32783615 | Despite being an integral component of airway innate immunity, the role of respiratory cilia and their clinical significance during airway infections are still poorly understood. | 2020-08-14 |
| 32783802 | Other common symptoms include cough, loss of appetite, fatigue, shortness of breath, sputum production, and muscle and joint pains. […] Symptoms such as nausea, vomiting and diarrhea have been observed in varying percentages. […] To determine the epidemiological and clinical characteristics of patients presenting with COVID-19 at the screening clinic of a tertiary care hospital in Peshawar, Pakistan.Methodology. […] We documented and analysed demographic, epidemiological and clinical characteristics, which included age, sex, travel history, clinical features, comorbidities and laboratory data of patients confirmed by real-time reverse-transcription (RT)-PCR at Rehman Medical Institute, Peshawar, Pakistan from 15 March till 21 April 2020. […] Common symptoms included fever (88 patients, 72 %), cough (72 patients, 59.5 %) and shortness of breath (69 patients, 57 %). […] In this single-centre, prospective, descriptive study, fever, cough and shortness of breath were the most common symptoms. | 2020-08-14 |
| 32783878 | Wastewater-based epidemiology is a powerful tool to understand the actual incidence of coronavirus disease 2019 (COVID-19) in a community because severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, can be shed in the feces of infected individuals regardless of their symptoms. | 2020-08-14 |
| 32783920 | Although the immunological mechanisms that underlie different clinical trajectories remain poorly defined, pathogen-specific antibodies often point to immunological mechanisms of protection. | 2020-08-14 |
| 32783921 | These factors include relatively increase of interleukin (IL)6R and IL6ST expression in COVID-19 patients but similarly increased IL-6 concentrations compared to IAV patients, supporting the clinical observations of increased proinflammatory cytokines in COVID-19 patients. | 2020-08-14 |
| 32784133 | We employ a simple local maxima detection technique in the Radon transform domain, associated with known clinical definitions of line artifacts. | 2020-08-14 |
| 32784192 | The purpose of this study is to evaluate the overall clinical effectiveness of HCQ and TCZ in patients with COVID-19. […] A retrospective cohort study was performed to determine the impact of HCQ and TCZ use on hard clinical outcomes during hospitalization. […] These results are similar to the recently published preliminary results of the HCQ arm of the Recovery trial, which showed no clinical benefit from the use of HCQ in hospitalized patients with COVID-19 (the TCZ arm is ongoing). | 2020-08-14 |
| 32784217 | In this retrospective case series, clinical outcomes and correlates of response to treatment with the IL-6 receptor antagonist sarilumab are described for 15 patients with COVID-19 from a single institution in Southern Italy. […] Among 10 patients whose symptoms improved after sarilumab treatment, rapid decreases in CRP levels corresponded with clinical improvement. […] This observation may reflect a possible clinical benefit regarding early intervention with IL-6-modulatory therapies for COVID-19 and that CRP could be a potential biomarker of response to treatment. | 2020-08-14 |
| 32784234 | COVID-19 may be a potential cause of peripheral facial paralysis and neurological symptoms could be the first and only manifestation of the disease. | 2020-08-14 |
| 32784235 | We report the case of a 32-year-old woman who presented with reducible indirect inguinal hernia and a challenging constellation of symptoms, signs and radiographic findings. […] This so-called ‘female hydrocoele’ is an eponymous anatomical rarity in general surgery, presenting as an inguinolabial swelling with variable clinical profile. | 2020-08-14 |
| 32784239 | Pregnancy itself can alter the body’s response to viral infection, which can cause more severe symptoms. | 2020-08-14 |
| 32784241 | Beyond the typical respiratory symptoms and fever associated with severe acute respiratory syndrome, we may still have much to learn about other manifestations of the novel SARS-CoV-2 infection. | 2020-08-14 |
| 32784242 | Clinical examination revealed global weakness, increased tone, hyperreflexia and patchy paresthesia in his lower limbs bilaterally. […] His neurological symptoms improved significantly after treatment with intravenous methylprednisone. | 2020-08-14 |
| 32784244 | Her psychotic symptoms initially improved with antipsychotics and benzodiazepines and further improved with resolution of COVID-19 symptoms. […] This is the first case of COVID-19-associated psychosis in a patient with no personal or family history of a severe mood or psychotic disorder presenting with symptomatic COVID-19, highlighting the need for vigilant monitoring of neuropsychiatric symptoms in these individuals. | 2020-08-14 |
| 32784290 | SARS-CoV-2 is responsible for development of COVID-19 in infected individuals, who can either exhibit mild symptoms or progress towards a life-threatening acute respiratory distress syndrome (ARDS). […] Exacerbated inflammation and dysregulated immune responses involving T and myeloid cells occur in COVID-19 patients with severe clinical progression. […] Here, we have studied the frequencies and activation profiles of dendritic cells and monocytes present in the blood and lung of COVID-19 patients with different clinical severity in comparison with healthy individuals. | 2020-08-14 |
| 32784414 | SARS-CoV-2, and several other microorganisms, may be present in nasopharyngeal and salivary secretions in patients treated in dental practices, so an appropriate clinical behavior is required in order to avoid the dangerous spread of infections. | 2020-08-14 |
| 32784463 | Finally, we hope that these materials could be helpful in treating COVID-19 patients, because A. lavenia extracts and NRF2 activators have been reported to alleviate the symptoms of pneumonia in model animals. | 2020-08-14 |
| 32784499 | Presently, a tremendous surge of COVID-19 clinical trials are advancing through different stages. […] Among currently registered clinical efforts, ~86% are centered on testing small molecules or antibodies either alone or in combination with immunomodulators. […] The rest ~14% of clinical efforts are aimed at evaluating vaccines and convalescent plasma-based therapies to mitigate the disease’s symptoms. […] This review provides a comprehensive overview of current therapeutic modalities being evaluated against SARS-CoV-2 virus in clinical trials. | 2020-08-14 |
| 32784543 | Gitelman’s syndrome (GS) and Bartter’s syndrome (BS) are rare inherited salt-losing tubulopathies whose variations in genotype do not correlate well with either clinical course or electrolyte requirements. […] Understanding the myriad of distinctive and frequently overlapping clinical presentations of GS/BS arises remains challenging. […] We suggest that linkage between the specific gene defects identified in GS and BS and the myriad of distinctive and frequently overlapping clinical findings may be the result of aberrant glycosylation of ACE2 driven by altered TGN/endosome system acidification caused by the metabolic alkalosis brought about by these salt-losing tubulopathies in addition to their altered intracellular calcium signaling due to a blunted second messenger induced intracellular calcium release that is, in turn, amplified by the RAS system. | 2020-08-14 |
| 32784685 | Using the ClinicalTrials.gov and World Health Organization (WHO) databases, we shed light on the 16 current approved clinical trials worldwide in search for a COVID-19 vaccine. | 2020-08-14 |
| 32784696 | Pharmacies have transitioned from being compounding centers devoted to the manipulation of materia medica to pharmaceutical centers, clinical pharmacies and fully integrated “medical-pharmaceutical networks”, providing a significant range of non-prescribing services. | 2020-08-14 |
| 32784802 | More studies are required to investigate whether variations of ACE2 expression could explain the severity of COVID-19 infection-related symptoms between diabetics and non-diabetic patients. | 2020-08-14 |
| 32784826 | This is because it may be hypothesized that the different patterns with which the pathology is expressed could depend on different individual susceptibility to infection or a different personal genetic-clinical background. | 2020-08-14 |
| 32784922 | Nevertheless, randomized clinical trials aiming to identify effective and safe drugs against SARS-CoV-2 infection are urgently needed in order to confirm or reject the currently available evidence. | 2020-08-14 |
| 32785110 | HCWs were regularly tested with nasopharyngeal swabs for SARS-CoV-2; body temperature and suggestive symptoms were evaluated at each duty. […] Demographic and clinical data of both patients and HCWs were collected and analyzed; HCWs’ personal protective equipment (PPE) consumption was also recorded. | 2020-08-14 |
| 32785285 | The Covid-19 pandemic threatens to overwhelm scarce clinical resources. | 2020-08-14 |
| 32785450 | The median time between the onset of symptoms and the release of laboratory results was 12 days for the analyzed period. | 2020-08-14 |
| 32785649 | This outcome is unlikely because coronavirus diseases in humans lack the clinical, epidemiological, biological or pathological attributes of ADE disease exemplified by the dengue viruses (DENV). | 2020-08-14 |
| 32785701 | While molecular-based and antibody tests remain the reference standard method for confirming a SARS-CoV-2 diagnosis, their clinical sensitivity is not well known. | 2020-08-14 |
| 32785710 | Parallel, double-blind, placebo-controlled, randomized, phase IIb clinical trial was performed with hospitalized patients aged ≥ 18 years with clinical, epidemiological and/or radiological suspected COVID-19, at a tertiary care facility in Manaus, Brazil. | 2020-08-14 |
| 32785756 | Of all the participants, 131 (29.18%) had anxiety symptoms. […] Chinese Clinical Trial Registry: ChiCTR2000030768, 2020/3/14. | 2020-08-14 |
| 32785803 | The final report was built in the management of radiology report template (MRRT) and includes n = 4 items in the procedure information, n = 5 items in the clinical information, n = 16 in the findings, and n = 3 in the impression, with overall 28 items. | 2020-08-14 |
| 32785855 | Aims of this review are to describe LU and chest HRCT main imaging features of COVID-19 pneumonia, and to provide state-of-the-art insights regarding the integrated role of these techniques in the clinical decision-making process of patients affected by this infectious disease. | 2020-08-14 |
| 32785885 | These cases highlight that commercial ELISAs and even rapid tests might significantly aid the diagnosis of COVID-19, particularly, if a combination of serological assays is used with a specific clinical question, in severely ill patients after seroconversion and when comprehensive serological methods are used for confirmation. | 2020-08-14 |
| 32786150 | This psychological distress was predominantly described as sleep disturbance, symptoms of anxiety and depression, post-traumatic stress, inability to make decisions and even somatic symptoms. | 2020-08-14 |
| 32786157 | Through purposeful and snowball sampling, 11 health professionals who had experienced hospital isolation due to suspicious symptoms of Middle East respiratory syndrome during the outbreak, participated in face-to-face interviews (50-90 min). | 2020-08-14 |
| 32786163 | Baby-Boomer nurses can leverage alternative work arrangements to meet their needs and to contribute to clinical practice through telecommuting. […] Clinical experience matters at the bedside. […] Telecommuting maximizes the retention of Baby-Boomer nurses’ clinical expertise to benefit patients and to socialize bedside nurses. | 2020-08-14 |
| 32786280 | Clinically, the diagnosis of this unprecedented illness, called coronavirus disease-2019 (COVID-19), becomes difficult because it shares many symptoms with other respiratory pathogens, including influenza and parainfluenza viruses. […] Therefore, laboratory diagnosis is crucial for the clinical management of patients and the implementation of disease control strategies to contain SARS-CoV-2 at clinical and population level. […] Here, we summarize the main clinical and imaging findings of COVID-19 patients and discuss the advances, features, advantages, and limitations of different laboratory methods used for SARS-CoV-2 diagnosis. | 2020-08-14 |
| 32786401 | Given the ability of the COVID-19 virus to infect a wide array of tissue types, inclusion of the (RP)-diastereomer may be of clinical significance. | 2020-08-14 |
| 32786691 | These infections are associated with the development of a disease known as COVID-19, which is characterized by several symptoms, including persistent dry cough, shortness of breath, chills, muscle pain, headache, loss of taste or smell, and gastrointestinal distress. | 2020-08-14 |
| 32787373 | We prospectively gathered patients’ reported outcomes concerning respiration-related symptoms at four different time points, including: (I) at admission; (II) at the time of hospital discharge; (III) two weeks after discharge; (IV) four weeks after discharge. […] The reported respiratory symptoms included dry cough, productive cough, difficulty in expectoration, and dyspnea. […] Based on current findings on pronouncedly improved remission rate in respiratory symptoms, we recommend the MRE as suitable rehabilitation exercise to smooth respiration and ease the expectoration process in mild COVID-19 cases. | 2020-08-14 |
| 32787378 | The new emerging infectious disease has raised many challenges and uncertainties regarding disease management and prognosis in immunocompromised patient populations. […] After infected with COVID-19, the patient had no other clinical symptoms and laboratory abnormalities throughout the course of the disease except presented with fever for a short-term (2 days), and no secondary infection or exacerbation occurred after admission in hospital. | 2020-08-14 |
| 32787379 | This review aims to discuss prognostication in low grade versus high grade gliomas, variability in treatment of these tumors, clinical features of poor prognosis, and differences in prognostic understanding between patients, caregivers, and providers. | 2020-08-14 |
| 32787389 | Conversations about end-of-life care can occur without fear that a person’s psychiatric symptoms or related vulnerabilities will undermine the process. | 2020-08-14 |
| 32787398 | Coupled with a lack of adequate personal protective equipment and the scarcity of knowledge on the possible interaction between malaria and COVID-19 both in terms of presentations and shared symptoms, this has left many frontline health workers with fears and anxieties. | 2020-08-14 |
| 32787442 | Medical records of patients who underwent thoracic surgery from March 18, 2020 to May 17, 2020 were reviewed retrospectively. | 2020-08-14 |
| 32787597 | Outcomes measured included study characteristics, cancer type, phase of care at the time of diagnosis, and clinical presentation. | 2020-08-14 |
| 32787700 | Materials and Methods The demographics, clinical presentation, injuries, and radiological findings of patients reporting physical abuse arising from IPV during the statewide COVID-19 pandemic between March 11th and May 3rd, 2020 were compared with the same period over the past three years. | 2020-08-14 |
| 32787701 | Background The prognosis of hospitalized patients with severe coronavirus disease 2019 (COVID-19) is difficult to predict, while the capacity of intensive care units (ICUs) is a limiting factor during the peak of the pandemic and generally dependent on a country’s clinical resources. […] After univariable analysis, a risk model to predict critical illness (i.e. death and/or ICU admission with invasive ventilation) was developed, using multivariable logistic regression including clinical, CXR and laboratory findings. | 2020-08-14 |
| 32787748 | Pentoxifylline and oxypurinol are licensed drugs used for diseases other than COVID-19 and, therefore, phase I clinical trials would not be necessary for the administration to SARS-CoV-2- infected people. | 2020-08-14 |
| 32787752 | Through this review, several drugs were highlighted that can be evolved in vivo and clinical trials as possible used against these pathogens showed that remdesivir represent potential treatments against CoV. | 2020-08-14 |
| 32787782 | The coronavirus pandemic (Covid-19) presents a variety of challenges for ongoing clinical trials, including an inevitably higher rate of missing outcome data, with new and non-standard reasons for missingness. | 2020-08-14 |
| 32787815 | Results show that exposed HCPs working with patients during an epidemic/pandemic are at heightened risk of mental health problems in the short and longer term, particularly: psychological distress, insomnia, alcohol/drug misuse, and symptoms of posttraumatic stress disorder (PTSD), depression, anxiety, burnout, anger, and higher perceived stress. | 2020-08-14 |
| 32787822 | We have to conduct several cancer clinical trials in the presence of COVID-19. […] A comprehensive analytical strategy to analyse cancer clinical trial data during COVID-19 pandemic is presented. | 2020-08-14 |
| 32787929 | Posttraumatic stress (PTS) were prevalent in this sample of health care professionals, and 40.2% indicated positive screens for significant posttraumatic stress disorder symptoms. […] The proportion of having mild to extremely severe symptoms of depression, anxiety and stress were 13.6, 13.9 and 8.6%, respectively. […] Adverse psychological symptoms were prevalent among medical care workers in China during the COVID-19 epidemic. | 2020-08-14 |
| 32788008 | Clinical data of 12 patients with COVID-19 admitted to Shantou Central Hospital from January 23 to February 5 in 2020 were retrospectively analyzed, including gender, age, symptoms, lab test and clinical outcomes, to analyze the change trend of blood Na+ level in the patients with COVID-19. […] All patients had a positive nucleic acid test for 2019 novel coronavirus (2019-nCoV), and were discharged after clinical treatment with oxygen therapy, antiviral, antibacterial, anti-inflammatory, and nutritional support. | 2020-08-14 |
| 32788039 | We estimate that the effective reproduction number was likely below one in each Australian state since mid-March and forecast that clinical demand would remain below capacity thresholds over the forecast period (from mid-to-late April). | 2020-08-14 |
| 32788073 | Coronavirus disease 2019 (COVID-19) is presented with asymptomatic, mild, or severe pneumonia-like symptoms. | 2020-08-14 |
| 32788101 | The 2019 coronavirus disease (COVID-19) presents with a large variety of clinical manifestations ranging from asymptomatic carrier state to severe respiratory distress, multiple organ dysfunction and death. | 2020-08-14 |
| 32788120 | An individualised thromboprophylaxis was implemented in critically ill patients suffering from coronavirus disease 2019 (COVID-19) pneumonia to reduce mortality and improve clinical outcome. […] The aim of this study was to evaluate the effect of this intervention on clinical outcome. | 2020-08-14 |
| 32788129 | We then collected clinical, endoscopic and outcome variables from the patients of years 2019 and 2020. | 2020-08-14 |
| 32788148 | Institutions provide their constituents with a unique identifier to enter data through a web-based user interface to collect vetted symptoms as well as clinical and epidemiologic data. […] Safety features include instructions for people with new or worsening symptoms to seek care. […] One of the 48 users (2%) reported active COVID-19 infection and had no symptoms by the end of the monitoring period. […] No other participants reported symptoms. | 2020-08-14 |
| 32788159 | Clinical and laboratory manifestations of COVID-19 infection can mimic HELLP syndrome. | 2020-08-14 |
| 32788160 | These patients had no evidence of respiratory or influenza-like illness on admission and developed symptoms, with positive SARS-CoV-2 PCR test results, more than 7 days after admission (>14 days for 38 [5.7%] patients). […] Implementation of a triage system combining clinical assessment with rapid SARS-CoV-2 testing facilitated cohorting so that fewer susceptible patients were exposed to COVID-19 on shared wards. […] Point-of-care diagnostics can complement clinical assessment to rapidly identify patients with COVID-19 and reduce risk of transmission within hospitals. | 2020-08-14 |
| 32788235 | To report a multi-institutional case series of patients with advanced microsatellite instability high (MSI-H) prostate adenocarcinoma identified with clinical cell-free DNA (cfDNA) next-generation sequencing (NGS) testing and treated with immune checkpoint inhibitors. […] The use of liquid biopsy to identify metastatic prostate cancer patients with MSI-H is feasible in clinical practice and may overcome some of the obstacles associated with prostate cancer tumor tissue testing. | 2020-08-14 |
| 32788312 | Typical symptoms of COVID-19 include fever, cough, shortness of breath and fatigue, yet some atypical symptoms like loss of smell and taste have also been described. 20% require hospital admission due to severe disease, a third of whom need intensive support. | 2020-08-14 |
| 32788319 | The high frequency of aerosolizing procedures in the ICU, including endotracheal intubation, places clinical staff at elevated risk of contracting the 2019 coronavirus (COVID-19). […] A standard pre-intubation checklist was adapted and refined by consensus using a multidisciplinary and iterative process, then distributed to local staff for clinical use. | 2020-08-14 |
| 32788324 | The current work summarises the characteristics of SARS-CoV-2, the ocular distribution of the major SARS-CoV-2 binding protein, and the experimental and clinical evidence of the ocular transmission route. | 2020-08-14 |
| 32788391 | Identification of possible causal mechanisms might stimulate changes in clinical practice. | 2020-08-14 |
| 32788506 | Although most patients have mild symptoms or are even asymptomatic, there are patients who can develop serious complications such as acute respiratory distress syndrome or venous thromboembolism requiring mechanical ventilation and intensive care. | 2020-08-14 |
| 32788835 | The patients were either asymptomatic or had mild symptoms for COVID-19 disease. […] Of 122 patients 21 (17.21%) patients developed severe conditions of COVID-19, while total 111 (90.9%) experienced mild symptoms such as fever in 93 (76.22%) patients, cough in 23 (20.17%) and muscle pain were observed in total 8 (7%) patients. […] Furthermore our newly applied drugs combination (Lianhuaqingwen and Arbidol Hydrochloride) showed therapeutic effects in 5-7 days in patients with mild symptoms with 98% recovery rate. […] These results indicate that COVID-19 patients with mild symptoms can be treated with Lianhuaqingwen and Arbidol Hydrochloride. […] However, extensive clinical investigations are required to confirm the effectiveness of these drugs. | 2020-08-14 |
| 32788836 | The Saudi Society of Clinical Pharmacy (SSCP) acknowledges the substantial impact pharmacists can play during outbreaks. | 2020-08-14 |
| 32788869 | Objective: To retrospectively compare the clinical features and chest computed tomography (CT) characteristics of coronavirus disease 2019 (COVID-19) and pneumonia in lymphoma patients. […] The clinical features were recorded. | 2020-08-14 |
| 32788884 | We aimed to further clarify the clinical characteristics and the relationship between these features and disease severity. […] Methods: In this retrospective single-center study, demographic, clinical and laboratory data were collected and analyzed among moderate, severe and critically ill group patients. […] Common symptoms at onset of disease were fever (71.59%), cough (59.09%), dyspnea (38.64%) and fatigue (29.55%). 88 patients were divided into moderate (47 [53.41%]), severe (32 [36.36%]) and critically ill (9 [10.23%]) groups. […] Conclusion: We found some clinical characteristic and inflammatory cytokines could reveal the severity of COVID-19 during the outbreak phage. | 2020-08-14 |
| 32788913 | Also, Corticosteroids are recommended for severe cases only to suppress the immune response and reduce symptoms, but not for mild and moderate patients where they are associated with a high-risk side effect. | 2020-08-14 |
| 32788944 | Cancer patients require a careful clinical follow-up during the coronavirus disease 2019 (COVID-19) pandemic. | 2020-08-14 |
| 32788945 | Although the first documented cases in Wuhan, China were patients with severe respiratory symptoms including cough, fever, fatigue, and shortness of breath, the disease process can also be asymptomatic. | 2020-08-14 |
| 32789020 | However, after a few weeks, relapse occurred, as indicated by symptoms of acute meningoencephalitis. […] We therefore note that symptoms with neurologic involvement can be one of COVID-19’s first presentations, or they can appear at relapse. | 2020-08-14 |
| 32789044 | The patient had flu-like symptoms for three weeks but did not seek any medical help and eventually presented with Banti’s syndrome. | 2020-08-14 |
| 32789074 | To this end, the AIR was designed in an expedient manner in accordance with basic functionality established by the Medicines and Healthcare Products Regulatory Agency (United Kingdom) for provisional clinical use in light of COVID-19. | 2020-08-14 |
| 32789088 | The heterogeneous nature of the symptoms of the disease caused by SARS-CoV-2, coronavirus disease 2019 (COVID-19), ranging from being asymptomatic to severe acute respiratory distress syndrome (ARDS), has created significant interest in potential therapeutics. | 2020-08-14 |
| 32789108 | There are a lot of herbs or natural products with potential anti-coronavirus effects reported from in vitro experiments and despite criticism, many clinical trials on traditional herbal medicine for COVID-19 are being conducted. | 2020-08-14 |
| 32789142 | Prophylactic doses of anticoagulation may not be sufficient in patients with severe COVID-19 infection, but clinical trials of therapeutic dose anticoagulation are underway.Physicians should be vigilant and have a high suspicion for thrombosis in all patients with COVID-19 infection, even those who are anticoagulated.Presentations of thromboembolism and microemboli may be atypical. | 2020-08-14 |
| 32789143 | Clinical experience and scientific articles have shown that patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be paucisymptomatic or asymptomatic at the time of diagnosis. […] In these cases, lung ultrasound helped to raise clinical suspicion of COVID-19 pneumonia and facilitate diagnosis. | 2020-08-14 |
| 32789160 | The clinical appearance of the arm was suggestive of pseudoparalytic shoulder. | 2020-08-14 |
| 32789282 | The problem of underrepresentation in clinical research persists today. […] All published COVID-19 treatment-related clinical research studies with study participants in the United States were identified. […] Six studies (n = 3, observational; n = 3, randomized clinical trial) have been published to date with participants in the United States. | 2020-08-14 |
| 32789449 | The Global Rheumatology Alliance registry will provide highly useful, timely data to inform clinical care and identify further research priorities for people with rheumatic disease with coronavirus disease 2019. | 2020-08-14 |
| 32789505 | Interim analysis of ongoing randomized, double-blind, placebo-controlled, phase 1 and 2 clinical trials to assess an inactivated COVID-19 vaccine. […] Chinese Clinical Trial Registry Identifier: ChiCTR2000031809. | 2020-08-14 |
| 32789517 | COVID-19 was diagnosed by primary care or hospital physicians on the basis of fever and respiratory signs (eg, cough, dyspnea) or a clinical illness compatible with COVID-19; COVID-19 diagnoses were considered confirmed if real-time reverse transcriptase-polymerase chain reaction testing for severe acute respiratory syndrome coronavirus 2 on nasopharyngeal swab was positive and considered possible if the test had not been performed or results were negative. | 2020-08-14 |
| 32789604 | The clinical presentation and management of heparin-induced thrombocytopenia, which is a rare but life-threatening complication of heparin therapy, has not been described in those patients yet. | 2020-08-14 |
| 32789730 | The clinical relevance of microvascular thrombosis in this disease requires further research. | 2020-08-14 |
| 32789869 | The present study aimed to identify the echocardiographic findings in hospitalized COVID-19 patients and their utility in disease management. | 2020-08-14 |
| 32789988 | In this retrospective study, we reviewed and analyzed the patient characteristics and clinical data of 25 asymptomatic patients with COVID-19 who underwent urgent or emergency cardiac surgery at Tehran Heart Center Hospital, Iran, between 29 February and 10 April 2020. | 2020-08-14 |
| 32790006 | Favorable clinical outcomes are possible if timely management and drainage are performed unless ventricular failure develops. | 2020-08-14 |
| 32790028 | We retrospectively reviewed the medical records of lung cancer patients who were undergoing anticancer treatment at the National Hospital Organization Kyoto Medical Center (600 beds) in Kyoto, Japan, between 1 March 2020 and 31 May 2020. […] After the medical records were reviewed, the patients were assigned to one of two groups, depending on whether their lung cancer treatment schedule was delayed. | 2020-08-14 |
| 32790035 | The COVID-19 pandemic has produced significant changes in emergency medicine patient volumes, clinical practice, and has accelerated a number of systems-level developments. | 2020-08-14 |
| 32790065 | The controlled human infection model and specifically the human viral challenge model are not dissimilar to standard clinical trials while adding another layer of complexity and safety considerations. | 2020-08-14 |
| 32790075 | While awaiting clinical trial results to establish the efficacy of TCZ for COVID-19 related CRS, the potential for infections and TCZ related toxicities should be carefully weighed when considering use. | 2020-08-14 |
| 32790106 | We determined pooled estimates for clinical characteristics and outcomes in COVID-19 patients including subgroups by disease severity (based on World Health Organization Interim Guidance Report or Infectious Disease Society of America/American Thoracic Society criteria) and by country/region. […] Gastrointestinal (nausea, vomiting, abdominal pain) and respiratory symptoms (shortness of breath, chest pain) were associated with severe COVID-19, while pneumonia and end-organ failure were associated with mortality. […] Individuals with comorbidities and clinical features associated with severity should be monitored closely, and preventive efforts should especially target those with diabetes, malignancy, and immunosuppression. | 2020-08-14 |
| 32790181 | Among the 30 patients, eight were positive for IgA, seven were positive for IgG (N + S), and two for IgG (S1), at the first point (5-7 days from the onset of symptoms). | 2020-08-14 |
| 32790215 | Headache is one of the most frequent neurologic symptoms of Coronavirus disease 2019 (Covid-19). […] All patients 104/104 (100%) described systemic symptoms and 86/104 (82.7%) some neurologic symptoms. | 2020-08-14 |
| 32790216 | Headache was reported in up to one-third of the hospitalized patients; yet, the clinical characteristics of headache associated with coronavirus disease 2019 (COVID-19) have not been defined. […] Headache features in 13 PCR-confirmed COVID-19 patients with mild symptoms were reported. […] Patients specified severe, rapid onset, unrelenting headache with migraine-like features, as well as unusual sensory symptoms such as anosmia, and gastrointestinal symptoms such as diarrhea and loss of appetite and weight. […] Headaches associated with COVID-19 included features resembling migraine and/or atypical symptoms including anosmia and diarrhea. | 2020-08-14 |
| 32790253 | Another aspect that the medical community has faced in connection with the pandemic is the need to reorient specialized medical organizations that have not previously worked with patients with infectious diseases in order to create Clinical centers for the treatment of the new coronavirus infection COVID-19. | 2020-08-14 |
| 32790441 | In the wake of COVID-19, the capacity to track emerging trends in mental health symptoms and needs will guide public health responses at multiple ecological levels. […] Using Google Trends to track population-level mental health-related Google searches in the United States, this investigation identified pandemic-associated spikes in searches related to anxiety symptoms and remote treatments for anxiety, such as deep breathing and body scan meditation. | 2020-08-14 |
| 32790488 | A drug cocktail aimed at controlling cytokine actions would complement current clinical treatments and vaccine effectiveness for COVID-19 and serve as a prototype for future age-related infectious disease pandemics wherein the elderly population is especially vulnerable. | 2020-08-14 |
| 32790510 | Data on the setting of the exposure, reverse transcriptase polymerase chain reaction testing, and clinical characteristics of index and secondary cases were collected. […] There was potential recall bias regarding symptom onset among patients with COVID-19, and the symptoms and severity of index cases were not assessed at the time of exposure to contacts. | 2020-08-14 |
| 32790605 | Interconnected historical, policy, clinical, and community factors explain and underpin community-based participatory research approaches to advance the art and science of community engagement among African Americans in the COVID-19 era. | 2020-08-14 |
| 32790652 | Children are thought to have milder respiratory symptoms and to recover more quickly. | 2020-08-14 |
| 32790653 |
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2020-08-14 |
| 32790662 | Whereas early clinical effects of methanol and ethanol poisoning are similar (e.g., headache, blurred vision, nausea, vomiting, abdominal pain, loss of coordination, and decreased level of consciousness), persons with methanol poisoning might develop severe anion-gap metabolic acidosis, seizures, and blindness. […] Medical records were reviewed to abstract details missing from poison center call records. […] Clinicians should maintain a high index of suspicion for methanol poisoning when evaluating adult or pediatric patients with reported swallowing of an alcohol-based hand sanitizer product or with symptoms, signs, and laboratory findings (e.g., elevated anion-gap metabolic acidosis) compatible with methanol poisoning. | 2020-08-14 |
| 32790663 | The patients’ signs and symptoms were temporally associated with COVID-19 but presumed to have developed 2-4 weeks after acute COVID-19; all children had serologic evidence of infection with SARS-CoV-2, the virus that causes COVID-19 (1). […] The clinical signs and symptoms present in this first cluster included fever, rash, conjunctivitis, peripheral edema, gastrointestinal symptoms, shock, and elevated markers of inflammation and cardiac damage (1). […] A total of 203 (35.6%) of the patients had a clinical course consistent with previously published MIS-C reports, characterized predominantly by shock, cardiac dysfunction, abdominal pain, and markedly elevated inflammatory markers, and almost all had positive SARS-CoV-2 test results. […] The remaining 367 (64.4%) of MIS-C patients had manifestations that appeared to overlap with acute COVID-19 (2-4), had a less severe clinical course, or had features of Kawasaki disease. […] As the COVID-19 pandemic continues to expand in many jurisdictions, clinicians should be aware of the signs and symptoms of MIS-C and report suspected cases to their state or local health departments; analysis of reported cases can enhance understanding of MIS-C and improve characterization of the illness for early detection and treatment. | 2020-08-14 |
| 32790708 | We aimed to model the impact of coronavirus (COVID-19) on the clinical academic response in England, and to provide recommendations for COVID-related research. […] A stochastic model to determine clinical academic capacity in England, incorporating the following key factors which affect the ability to conduct research in the COVID-19 climate: (i) infection growth rate and population infection rate (from UK COVID-19 statistics and WHO); (ii) strain on the healthcare system (from published model); and (iii) availability of clinical academic staff with appropriate skillsets affected by frontline clinical activity and sickness (from UK statistics). […] Clinical academics in primary and secondary care in England. […] Equivalent of 3200 full-time clinical academics in England. […] Low and high strain on the health system (no clinical academics able to do research at 10% and 5% infection rate, respectively. […] Number of full-time clinical academics available to conduct clinical research during the pandemic in England. […] Near complete attrition of academia (87% reduction, <400 clinical academics) occurs 35 days after pandemic start for 11, 34, 62, 76 days respectively-with no clinical academics at all for 37 days in the “do-nothing” scenario. | 2020-08-14 |
| 32790804 | Real-time observational study using pseudonymised routine clinical data extracted out of reports from home visits, telephone- and physical consultations (iCAREdata). | 2020-08-14 |
| 32790836 | We aimed to compare the clinical observations and outcomes of SARS-CoV-2-infected patients with or without CVD. | 2020-08-14 |
| 32790891 | We analysed suspected patients reported to the National Surveillance System that corresponded to the following case definition: patients with respiratory symptoms and fever, who travelled to regions with local or community transmission or who had close contact with a suspected or confirmed case. […] We obtained a model suitable for the clinical diagnosis of COVID-19 based on routinely collected surveillance data. | 2020-08-14 |
| 32791036 | Besides lymphocytopenia, although neutralizing antibodies were rapidly and abundantly generated in patients, there were delayed receptor binding domain (RBD)- and nucleocapsid protein (NP)-specific T cell responses during the first 3 weeks after symptoms onset. | 2020-08-14 |
| 32791117 | We collected information on demographic and obstetric characteristics via extraction from case notes and health worker performance via direct observation by independent clinical researchers. | 2020-08-14 |
| 32791191 | Novel 2019 coronavirus (COVID-19) infection usually causes a respiratory disease that may vary in severity from mild symptoms to severe pneumonia with multiple organ failure. | 2020-08-14 |
| 32791192 | In patients with acute limb ischemia, we did not find an increase in the time between onset of symptoms and ED admission, during the ES. | 2020-08-14 |
| 32791199 | Prevalence estimates of SARS-CoV-2 infection and immune experience produced by this study will greatly improve our understanding of the spectrum of COVID-19 disease, its current penetration in various demographic, geographic, and occupational groups, and inform the range of symptoms associated with infection. | 2020-08-14 |
| 32791207 | This study was performed to assess the necessity for the RNA extraction, by comparing the efficacy of RT-qPCR in several direct approaches versus the gold standard RNA extraction, in the detection of SARS-CoV-2 in laboratory samples, as well as in clinical oro-nasopharyngeal SARS-CoV-2 swabs. […] The findings showed an advantage for the extraction procedure; however a direct no-buffer approach might be an alternative, since it identified more than 60% of positive clinical specimens. | 2020-08-14 |
| 32791241 | To summarize the existing literature and registered clinical trials on the efficacy and safety of convalescent plasma for treating coronaviruses, and discuss issues of feasibility, and donor and patient selection. […] The World Health Organization International Clinical Trials Registry and clinicaltrials.gov were searched to summarize the currently registered randomized clinical trials for convalescent plasma in COVID-19. […] Most COVID-19 reports described a potential benefit of convalescent plasma on clinical outcomes in severe or critically ill patients with few immediate adverse events. | 2020-08-14 |
| 32791258 | COVD-19 disease is characteristically respiratory in nature; however, some patients have gastrointestinal symptoms. | 2020-08-14 |
| 32791263 | However, further larger clinical studies are required to verify our results. | 2020-08-14 |
| 32791333 | Despite that, clinical information regarding the rehabilitation of patients with COVID-19 infection remains limited. […] This clinical phenomenon of exertional or positional-related desaturation has significantly slowed down the progression of rehabilitation in our patients. | 2020-08-14 |
| 32791382 | This paper describes the analytical and clinical performance of the assay at three centers: Johns Hopkins Hospital, St. | 2020-08-14 |
| 32791492 | Leveraging electronic health records (EHRs) to monitor outpatient clinical encounters may lead to the identification of emerging outbreaks. […] A significantly higher number of patients with respiratory complaints and diseases starting in late December 2019 and continuing through February 2020 suggests community spread of SARS-CoV-2 prior to established clinical awareness and testing capabilities. | 2020-08-14 |
| 32791493 | COVID-19 is an infectious disease characterized by various clinical presentations. […] Knowledge of possible symptoms and their distribution allows for the early identification of infected patients. […] To determine the distribution pattern of COVID-19 symptoms as well as possible unreported symptoms, we created an app-based self-reporting tool. […] The participants were reminded daily to report whether they were experiencing any symptoms and if they had been tested for SARS-CoV-2 infection. […] The mean number of reported symptoms among untested participants was 0.81 (SD 1.85). […] Participants with a positive test result had, on average, 5.63 symptoms (SD 2.82). […] Self-reported symptom tracking helps to identify novel symptoms of COVID-19 and to estimate the predictive value of certain symptoms. […] Clinical screening with a high pretest probability allows for the rapid identification of infections and the cost-effective use of testing resources. […] Based on our results, we suggest that loss of smell and taste be considered cardinal symptoms; we also stress that diabetes is a risk factor for a highly symptomatic course of COVID-19 infection. | 2020-08-14 |
| 32791497 | Since many new reports on COVID-19 rapidly appear, the present perspective should be seen as a focus for discussion to drive forward further understanding, research initiatives, and clinical management of COVID-19. | 2020-08-14 |
| 32791551 | Numerous inquiries from concerned physicians as well as ethics committees prompted the German Interdisciplinary Association for Intensive Care and Emergency Medicine (DIVI) together with seven other medical associations to work out a clinical-ethical recommendation on “Decisions on resource allocation in emergency and intensive care in the context of the COVID-19 pandemic”. | 2020-08-14 |
| 32791552 | Underlying cardiovascular disease (CVD) is associated with severe COVID-19 infection and adverse clinical outcomes. […] While COVID-19 predominantly causes respiratory symptoms, a substantial number of patients eventually develop an acute cardiovascular syndrome associated with an excessive risk of mortality. […] As multiple drugs are being investigated in ongoing clinical trials, potential cardiotoxicity remains an important issue. | 2020-08-14 |
| 32791568 | Evidence increasingly suggests that the symptoms of coronavirus disease-2019 (COVID-19)-related acute respiratory distress syndrome (ARDS) differ from those of classic ARDS. | 2020-08-14 |
| 32791580 | The COVID-19 patients without predominant symptoms may consult ENT doctors, even though the ENT department isn’t thought first front of the battle. | 2020-08-14 |
| 32791668 | Primary outcomes are timing of the disappearance of the main symptoms (including fever, asthenia, cough disappearance rate, and temperature recovery time), and serum cytokine levels. […] Secondary outcomes are timing of the disappearance of accompanying symptoms (such as myalgia, expectoration, stuffiness, runny nose, pharyngalgia, anhelation, chest distress, dyspnea, crackles, headache, nausea, vomiting, anorexia, diarrhea), negative COVID-19 results rates on two consecutive occasions (not on the same day), CT image improvement, average hospitalization time, occurrence rate of common type to severe form, clinical cure rate, and mortality. | 2020-08-15 |
| 32791675 | We will also search the Chinese Clinical Trial Registry (ChiCTR) and ClinicalTrials.gov (www.ClinicalTrials.gov) for ongoing trials with unpublished data, and the Conference abstracts will be searched manually. | 2020-08-15 |
| 32791699 | This systematic review protocol is designed to provide evidence regarding the effectiveness and safety of traditional Chinese medicine for the treatment of children with COVID-19, such evidence may be useful and important for clinical treatment decisions. | 2020-08-15 |
| 32791725 | Assessing the effectiveness and safety of traditional Chinese medicine (TCM) for symptoms of upper respiratory tract of coronavirus disease 2019 is the main purpose of this systematic review protocol. […] The primary outcome is the time and rate of appearance of main symptoms (including coughing, pharyngalgia, and nasal obstruction). […] The conclusion of our study will provide an evidence to judge whether TCM is effective and safe for the patients with symptoms of upper respiratory tract of coronavirus disease 2019. | 2020-08-15 |
| 32791731 | The pregnant women received nebulized inhalation and oral cephalosporin treatment in a community hospital and was discharged after the symptoms disappeared. […] The findings of this case report are useful for understanding the possible clinical features of COVID-19 infection in pregnant women, the duration of the antibody, and passive immunity of the fetus. | 2020-08-15 |
| 32791748 | We present an unique circumstance whereas a patient with a 5 year history of inflammatory muscle disease, diagnosed by clinical history and muscle biopsy with elevated creatine kinase levels, suffered a hypoxemic cardiopulmonary arrest due to asymptomatic SARS-CoV-2 after receiving advanced immunosuppressive therapy. | 2020-08-15 |
| 32791752 | We aimed to investigate their clinical and chest computed tomography (CT) characteristics.The clinical, laboratory test and CT features of 43 medical and hospital staff with confirmed COVID-19 (MP group, 26-70 years old) were retrospectively analyzed, and compared to 43 non-medical related patients (non-MP group, 26-71 years old). | 2020-08-15 |
| 32791753 | The primary outcome will be clinical efficacy, and the secondary results will be accompanying symptoms, time for the temperature to return to normal, time of novel coronavirus nucleic acid turning negative, blood sample test, Computed Tomography examination, length of hospitalization, adverse reactions, and adverse events. […] To provide the latest evidence of clinical efficacy and safety of arbidol in the treatment of COVID-19. | 2020-08-15 |
| 32791754 | We aim to assess the efficacy and safety of Lianhua Qingwen combined with Conventional antiviral Western Medicine in Clinical treatment of COVID-19 or asymptomatic infection. […] The following electronic bibliographic databases will be searched to identify relevant studies: CNKI, CBM, VIP and Wanfang databases, PubMed, EMBASE, MEDLINE, Cochrane central, and clinical trial registration centers, such as China Clinical Trial Registration Center (ChiCTR), Netherlands National Trial Registration Center (NTR) and clinical trials.gov. […] STATA15.1 and RevMan5.3 software were used to analyze meta outcomes of different intervention measures for the treatment of new crown pneumonia and the control group (conventional antiviral western medicine treatment) clinical efficacy. […] This study will provide a relatively high-quality synthesis of current evidence of Lianhua Qingwen combined with Conventional antiviral Western Medicine in the treatment of COVID-19 from several aspects including the Clinical effective rate, CT improvement rate, severe conversion rate, antipyretic time, disappearance rate of fever symptoms, disappearance rate of cough symptoms, disappearance rate of asthenia symptoms, and adverse drug events. | 2020-08-15 |
| 32791757 | The aim of this study was to examine the anxiety status of the frontline clinical nurses in the designated hospitals for the treatment of coronavirus disease 2019 (COVID-19) in Wuhan and to analyze the influencing factors, to provide data for psychologic nursing.This study used a cross-sectional survey design and convenience sampling. […] The questionnaires were completed by 176 frontline clinical nurses. […] The anxiety scores of the frontline clinical nurse fighting COVID-19 were 17.1 ± 8.1. […] Anxiety symptoms, mild to moderate anxiety symptoms, and severe anxiety symptoms were found in 27.3%, 25%, and 25% of the nurses, respectively. […] Sex, age, marital status, length of service, and clinical working time against COVID-19 were associated with anxiety (P < .05). […] Sex, age, length of service, and clinical working time against COVID-19 were associated with anxiety in those nurses. | 2020-08-15 |
| 32791953 | COVID-19 outbreak may thus have profound indirect consequences on clinical presentation and management of patients with ST-segment-elevation myocardial infarction (STEMI). […] Aim of this study was to assess clinical features of patients with STEMI during COVID-19 pandemic. […] These patients were compared with a historical cohort of patients admitted for STEMI during the analogous time period (February 21 to April 1) in 2018 and 2019, in terms of time from symptoms onset to hospital admission, clinical characteristics, and in-hospital outcomes. […] Median (interquartile range) time from symptoms onset to hospital admission was significantly longer in 2020 as compared to the historical cohort (15.0 [2.0-48.0] versus 2.0 [1.0-3.0] hours; P<0.01). […] These preliminary results from a cardiovascular regional public service healthcare hub demonstrate a significantly longer time from symptoms onset to hospital admission among patients with STEMI during COVID-19 pandemic compared with the same time period in the previous 2 years. | 2020-08-15 |
| 32792041 | We systematically reviewed the existing clinical evidence of HCQ use for the prevention and treatment of COVID-19. […] We screened for clinical studies describing HCQ administration to treat or prevent COVID-19 in PubMed. […] As a whole, RCTs, including one large British RCT that has not yet been published, showed no significant effect of HCQ on mortality rates, clinical cure, and virologic response. | 2020-08-15 |
| 32792042 | A key strategy for confronting the disease implications on individuals and communities was based on harnessing multidisciplinary efforts to develop technologies for mitigating the disease spread and its deleterious clinical implications. […] At this stage, some of the described technologies are still in developmental or clinical evidence generation phases with respect to COVID-19 settings. | 2020-08-15 |
| 32792043 | Although a high case fatality ratio was common to all pandemic diseases, some striking clinical characteristics of each disease allowed contemporaneous people to clinically diagnose the infection despite null microbiological information. | 2020-08-15 |
| 32792044 | It explains the clear distinction between the technical characteristics of the tests, the detection measures, and the diagnostic measures that have clinical and public health implications. | 2020-08-15 |
| 32792046 | Infection can result in a wide range of clinical outcomes, from an asymptomatic condition to severe bilateral pneumonia and life-threatening conditions. […] Diagnosis is based on the combination of a history of exposure, clinical presentation, and real-time polymerase chain reaction (RT-PCR) assays. | 2020-08-15 |
| 32792048 | This perspective piece focuses on the main challenges faced by Italian hospital managements: hospital overcrowding; the need for urgent reorganization of the country’s healthcare systems; the lack of data regarding COVID-19 diagnostics, clinical course, and effective treatment; individual and collective consequences of the crisis; and the importance of disease containment measures and early treatment strategies. | 2020-08-15 |
| 32792167 | This report sheds light on available information for a better understanding of clinical trials and pharmacotherapy related to COVID-19. […] MEDLINE, PubMed, EMBASE, Scopus databases, Web of Science, WHO, and EU clinical trial sites were used to perform comparative analysis. […] We have extracted data from 60 clinical trials. […] Amongst these trials, 34 were from the European Union database of clinical trials and 26 from the National Institute of Health. […] Most of the clinical trials are ongoing and hence, there is a lack of precise results for the treatment.There is a lack of high-quality clinical evidence. […] The protocol to be developed requires large randomized clinical trials with a combination of available drugs and prospective therapies. […] We propose the usage of a large number of cases and different statistical analyses to conduct systematic clinical trials. […] This could provide comprehensive information about the clinical trial and potential therapeutic progress. | 2020-08-15 |
| 32792249 | We, then examined, retrospectively and prospectively, the clinical course during hospitalization by performing serial examinations of serum SARS-CoV-2 RNA status. […] The findings from our cases suggest that not only is detection of viremia useful as a predictive marker of severity, but also serial serum SARS-CoV-2 RNA results can be helpful for predicting the clinical course. | 2020-08-15 |
| 32792254 | The primary outcomes included scores that represented changes in symptoms and signs over the course of treatment. | 2020-08-15 |
| 32792255 | Ninety participants in an ongoing clinical trial of a risk reduction program for homeless, aged 18-25 years, were administered items about COVID-19 between April 10 and July 9, 2020. […] Past week mental health symptoms were reported by 38%-48% of participants, depending on symptoms. | 2020-08-15 |
| 32792262 | The objective of this study is to review the literature and describe clinical presentations among pregnant women afflicted with COVID-19. | 2020-08-15 |
| 32792326 | We developed and disseminated a survey, which included the Generalized Anxiety Disorder 7-Item Scale (GAD-7), to all general and integrated plastic surgery residents in their clinical years of training at the University of California, San Francisco. | 2020-08-15 |
| 32792417 | We additionally list the ongoing registered clinical trials for CP throughout the world and discuss the trial results published thus far. | 2020-08-15 |
| 32792455 | In our study, we aim to assess the efficacy of the e-mental health intervention ‘CoPE It’ in terms of reducing distress (primary outcome), depression and anxiety symptoms as well as improving self-efficacy, quality of life and mindfulness (secondary outcomes). | 2020-08-15 |
| 32792492 | To describe the epidemiological and clinical characteristics of patients with Corona Virus Disease 2019 (COVID-19) in Beijing. […] We collected information on demographic characteristics, exposure history, clinical characteristics, corticosteroids use, and outcomes of the 65 confirmed cases of COVID-19 at Fifth Medical Center of PLA General Hospital from Jan 20 to Feb 23, 2020. | 2020-08-15 |
| 32792598 | Here we report the clinical and histologic findings related to the liver in 40 patients who died of complications of COVID-19. | 2020-08-15 |
| 32792851 | An important number of studies have reported the onset of symptoms compatible with pneumonia accompanied by coagulopathy and lymphocytopenia during COVID-19. | 2020-08-15 |
| 32792998 | Among all 2,031 respondents, 14.81%, 18.3%, and 9.98% had depression, anxiety and stress symptoms, respectively. […] Males, doctors, individuals aged between 31‑60 years, those with senior job titles, those who had contact with patients with confirmed or suspected cases of COVID-19, those who worked on the clinical frontlines fighting the epidemic and those who had experience combating similar outbreaks were more likely to have depression, anxiety or stress symptoms. | 2020-08-15 |
| 32793008 | Sociodemographic and clinical variables of a sample of 123 OCD outpatients, currently attending three OCD tertiary clinics in Northern Italy, were assessed through telephone and in-person interviews. […] Patients showing a clinical worsening of OCD represented more than one third of the sample and reported a significant emergence of new obsessions and compulsions phenotypes along with a significant exacerbation of past ones. | 2020-08-15 |
| 32793014 | About 61.6% of the respondents reported sleep problems, 22.6% experienced anxiety, and 35% exhibited depressive symptoms. | 2020-08-15 |
| 32793245 | In addition, a few vaccine candidates have only recently entered human clinical trials, which hampers the progress in tackling COVID-19 infection. […] Here, we discuss potential prophylactic interventions for SARS-CoV-2 with a focus on the challenges existing for vaccine development, and we review pre-clinical progress and ongoing human clinical trials of COVID-19 vaccine candidates. | 2020-08-15 |
| 32793246 | To prevent and stop the COVID-19 pandemic, several clinical trials are in the pipeline. […] The current clinical trials either target the intracellular replication and spread of the virus or the cytokine storm inflammation seen in COVID-19 cases during the later stages of the disease. | 2020-08-15 |
| 32793354 | From March to April, clinical microbiology laboratory Universitas Indonesia in Jakarta received 4617 specimens with 12.6% positivity rate and 22% asymptomatic case. | 2020-08-15 |
| 32793398 | Clinical development of the COVID-19 vaccine candidate ChAdOx1 nCoV-19, a replication-deficient simian adenoviral vector expressing the full-length SARS-CoV-2 spike (S) protein was initiated in April 2020 following non-human primate studies using a single immunisation. | 2020-08-15 |
| 32793434 | We no longer experience the same quality of life and need to come up with effective solutions to combat the clinical implications. | 2020-08-15 |
| 32793615 | Despite the majority of the general population displaying symptoms similar to the common cold, COVID-19 has also induced alveolar damage resulting in progressive respiratory failure with fatalities noted in 6.4% of cases. […] Research has revealed several agents that may have potential efficacy against COVID-19, and many of these molecules have demonstrated preliminary efficacy against COVID-19 and are currently being tested in clinical trials. | 2020-08-15 |
| 32793618 | In contrast, in patients after discharge, chest physiotherapy in the form of respiratory muscle training, cough exercise, diaphragmatic training, stretching exercise, and home exercise have resulted in improved FEV1 (L), FVC (L), FEV1/FVC%, diffusing lung capacity for carbon monoxide (DLCO%), endurance, and quality of life, and a reduction in anxiety and depression symptoms. | 2020-08-15 |
| 32793619 | Therefore, the impact of pre-existing liver disease on treatment and clinical outcomes of COVID-19 should be determined. […] Large-scale clinical studies are needed to identify the causes of liver injury in patients with COVID-19 infection. | 2020-08-15 |
| 32793620 | There have been no published systematic reviews that combine clinical, laboratory, epidemiologic, and mortality findings. […] Fever (83.0%, CI 77.5-87.6) and cough (65.2%, CI 58.6-71.2) were the most common symptoms. | 2020-08-15 |
| 32793661 | Most of them were descriptive studies and concentrated on the clinical features. […] The published literatures have focused on three topics: disease management, clinical features and pathogenesis. | 2020-08-15 |
| 32793662 | Researchers in China and around the world have conducted many clinical studies on the scientific response to infectious diseases. […] Here, we review and summarize the registration protocols for clinical research of the novel coronavirus disease (COVID-19). […] We searched all the registered studies in all platforms under the International Clinical Trials Registry Platform (ICTRP) of the World Health Organization (WHO) before March 11, 2020, screened the registration scheme for novel coronavirus, extracted the basic research information, research quality, feasibility information, and described the scientificity and feasibility of interventional research. […] From January 23, 2020 to March 11, 2020, 379 clinical studies were registered, 260 were therapeutic studies among them, and 96.8% studies were conducted in China by Chinese researchers. […] COVID-19 clinical study registration has been considerable, rapid, and high quality in study design. | 2020-08-15 |
| 32793693 | Limited studies have reported the clinical and epidemiological characteristics of children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] Considering the mild symptoms in infected children, the possibility that children may be a source of the transmission should not be ignored. | 2020-08-15 |
| 32793703 | The hospital stay is one of the prognostic indicators, and its predicting model based on CT radiomics features is important for assessing the patients’ clinical outcome. | 2020-08-15 |
| 32793725 | This study aimed to assess the clinical outcomes of critically ill COVID-19 patients using Tocilizumab treatment to provide recommendations for the treatment of COVID-19 patients with severe disease. […] This was a retrospective analysis of medical records of six critically ill patients admitted to the Third People’s Hospital of Shenzhen, China, from January 11 to February 26, 2020. […] Patient-related outcomes, including demographic, clinical, and laboratory characteristics before and after the initiation of Tocilizumab, were descriptively analyzed. […] Clinical symptoms, including fever, heart rate, and oxygen levels, improved after Tocilizumab use. […] Further prospective, randomized controlled clinical trials are called for. | 2020-08-15 |
| 32794002 | To determine prevalence, severity, duration, and time from onset to diagnosis of general and Otorhinolaryngologic symptoms related to COVID-19 in whole disease spectrum: from mild to critical patients. […] All adult patients with positive SARS-CoV-2 RNA found in nasopharyngeal and oropharyngeal swabs between March 10 and April 21, 2020 were surveyed by the authors for new onset symptoms during disease course. […] Demographic features, general symptoms, and Otorhinolaryngological symptoms were evaluated and compared by disease severity. […] The most common general symptoms were fatigue, cough, and fever with respective frequencies of 71.3%, 54.3%, and 50.7%. […] The most common Otorhinolaryngologic symptoms were taste loss, smell loss, and sore throat with respective frequencies of 34.5%, 31.8%, and 26%. […] Prevalence of other symptoms did not differ between groups. […] When compared to the previous studies, while general symptoms were less common, Otorhinolaryngologic symptoms were more common in our study population. | 2020-08-15 |
| 32794113 | To describe clinical characteristics of patients with rheumatic and musculoskeletal diseases (RMDs) and immunosuppressive therapies with Coronavirus disease 2019 (COVID-19) at an academic rheumatology center in Madrid and to identify baseline variables associated with a severe infection requiring hospitalization. | 2020-08-15 |
| 32794209 | The clinical data of 83 confirmed COVID-19 subjects were collected, with 60 patients who were symptomatic but negative for COVID-19 recruited as controls. […] However, the severity of and recovery from these symptoms have no correlations with the viral load of SARS-CoV-2. | 2020-08-15 |
| 32794366 | Eight persons presented COVID-19 symptoms, six were confirmed via SAR-CoV-2 chemoluminescent immunoassays, and the four related by blood presented skin manifestations. | 2020-08-15 |
| 32794386 | Given the importance of the presence of diabetes mellitus (DM) for host immunity, we retrospectively evaluated the clinical characteristics and outcomes of moderate-to-severe COVID-19 in patients with diabetes. […] Prior use of a dipeptidyl peptidase-4 inhibitor or a renin-angiotensin system inhibitor did not affect mortality or the clinical severity of the disease. | 2020-08-15 |
| 32794415 | Patients with cardiovascular disease (CVD) with COVID-19 have different clinical characteristics and prognostic outcomes. […] This study aimed to summarize the clinical characteristics and laboratory indicators of patients with COVID-19 with CVD, especially the critically ill patients. […] Clinical, laboratory, and outcome data were collected from the patients’ medical records and compared between the 2 groups. | 2020-08-15 |
| 32794435 | Demographic data, patient symptoms, drugs/doses for symptom control, and patient outcomes were captured for all COVID-19 positive patients referred to Hospital Palliative Care Teams between 30th March and 26th April 2020. […] Dyspnoea and agitation were the most prevalent symptoms (median 2 symptoms per patient). 75% of patients were prescribed continuous subcutaneous infusion for symptom control, which was effective in 78.6% of patients. […] Such symptoms can be effectively controlled with standard doses of opioids and benzodiazepines. | 2020-08-15 |
| 32794439 | The purpose of this clinical paper is to provide an overview of the National Coalition of Ethnic Minority Nurse Associations (NCEMNA), present COVID-19 epidemiological data on five racial-ethnic groups, identify culturally congruent health care strategies for each group, and provide directions for practice and research. […] Method: NCEMNA collaborated to provide a clinical paper that addresses information about COVID-19 and culturally congruent health care in five racial-ethnic groups. | 2020-08-15 |
| 32794454 | Clinical data and routine laboratory tests of a consecutive series of 30 COVID-19 patients and 30 age and sex matched patients with non COVID-19 interstitial pneumonia have been retrospectively collected. | 2020-08-15 |
| 32794460 | Both of SARS-CoV-2 and M. tuberculosis tests were requested on the clinical and radiological grounds in 30 patients. | 2020-08-15 |
| 32794463 | Currently, there are several experimental therapies with demonstrated in vitro activity against COVID-19 used in clinical practice, including hydroxychloroquine, remdesivir, interleukin-6 pathway inhibitors, and convalescent plasma; however, to date no agent has proven efficacy against COVID-19. […] Recently, the use of convalescent plasma has shown promising results in preliminary studies, with case series reporting a decrease in temperature, and viral load, as well as improvement in clinical parameters among patients receiving this treatment. | 2020-08-15 |
| 32794464 | All patients confirmed as having COVID-19 between 23 January and 25 March 2020 by RT-PCR assay in the clinical lab of Shantou CDC were included and divided into three groups based on the source of identification: hospital diagnosis, contact tracing, and community screening. | 2020-08-15 |
| 32794466 | Limited published clinical data, scarcity and long turn over time of diagnostic testing put clinician in dilemma to make diagnosis. […] We collected patient’s demography, symptoms, comorbidities, therapy, laboratory, chest x-ray and ECG consecutively. […] Clinical symptoms were dyspnea in 22 (73.3%) and dry cough 16 (53.3%). […] This is most likely due to late referral from primary care and unspecific clinical features resemblance of other infectious diseases. | 2020-08-15 |
| 32794597 | Fever and cough are the dominant symptoms with 15% of patients developing severe illness especially in the elderly and those with concurrent illnesses. | 2020-08-15 |
| 32794675 | This article, based on Prevention and Treatment of Pressure Ulcers/Injuries: Quick Reference Guide 2019, references, and clinical experiences of wound specialists in West China Hospital of Sichuan University, summarize the preventive and protective measures of West China Hospital for medical personnel to prevent DRPI, so as to provide clinical preventive measurements for medical personnel. | 2020-08-15 |
| 32794723 | Recent studies indicate that both COVID-19 incidence and total deaths are strongly associated with the presence or absence of national mandatory BCG vaccination programs and encourage the initiation of several clinical studies with the expectation that revaccination with BCG could reduce the incidence and severity of COVID-19. | 2020-08-16 |
| 32795131 | Here, we report clinically cured cases with positive results only in anal swabs, and investigate the clinical value of anal swabs for SARS-CoV-2 detection. | 2020-08-16 |
| 32795225 | We reviewed clinical characteristics and outcomes from patients with cancer and concurrent COVID-19 at Memorial Sloan Kettering Cancer Center until March 31, 2020 (n = 309), and observed clinical end points until April 13, 2020. […] In secondary analyses, we estimated associations between specific clinical and laboratory variables and the incidence of a severe or critical COVID-19 event. | 2020-08-16 |
| 32795227 | A total of 53 of 1,016 (5.2%) patients self-reported symptoms potentially associated with COVID-19. | 2020-08-16 |
| 32795413 | ARCoV is currently being evaluated in phase 1 clinical trials. | 2020-08-16 |
| 32795547 | This review highlights the underlying mechanisms, advancements, and clinical limitations for each of the diagnostic techniques authorized by the Food and Drug Administration (USA). […] Significance of diagnosis triaging, information on specimen collection, safety considerations while handling, transport, and storage of samples have been highlighted to make medical and research community more informed so that better clinical strategies are developed. […] We have discussed here the clinical manifestations and hospital outcomes along with the underlying mechanisms for several drugs administered to COVID-19 prophylaxis. […] In addition to favourable clinical outcomes, the challenges, and the future directions of management of COVOD-19 are highlighted. | 2020-08-16 |
| 32795645 | Person-to-person transmission through infected respiratory droplets from patients with symptoms and asymptomatic carriers is the main mode of spread in the community. | 2020-08-16 |
| 32795776 | Clinical characteristics and laboratory test results including SARS-CoV-2 PCR results were retrieved. | 2020-08-16 |
| 32795835 | In order to determine if teprotumumab may reduce lung injury and death related to ARDS in the setting of COVID-19, preliminary clinical data is needed. | 2020-08-16 |
| 32795897 | Subgroup analysis was carried out according to clinical classification. | 2020-08-16 |
| 32795902 | Although numerous pharmacologic therapies to improve clinical outcomes in CARDS have been studied also in clinical trials, none have shown efficacy and there is great uncertainty about their effectiveness. […] There is still no recommendation for the therapeutic use of any specific agent to treat CARDS because no drugs are validated to have significant efficacy in clinical treatment of COVID-19 patients in large-scale trials. | 2020-08-16 |
| 32796159 | The COViD-19 pandemic has revealed deep gaps in our understanding of the clinical nuances of this extremely infectious viral pathogen. […] In order for public health, care delivery systems, clinicians and other stakeholders to be better prepared for the next wave of SARS-CoV-2 infections, which, at this point, seems inevitable, we need to better understand this disease-not only from a clinical diagnosis and treatment perspective-but also from a forecasting, planning, and advanced preparedness point of view. […] To predict the onset and outcomes of a next wave, we first need to understand the pathologic mechanisms and features of COViD-19 from the point of view of the intricacies of clinical presentation, to the nuances of response to therapy. […] Here, we present a novel approach to model COViD-19, utilizing patient data from related diseases, combining clinical understanding with artificial intelligence modeling. | 2020-08-16 |
| 32796176 | There was no difference in the presenting symptoms of the cases and controls, and no difference in severity of COVID-19 manifestations (P > 0.05) was observed. […] In COVID-19 patients with GIB, compared with matched controls of COVID-19 patients without GIB, there seemed to be no difference in initial presenting symptoms. | 2020-08-16 |
| 32796181 | To describe the importance of critical care clinical research that is not pandemic-focused during pandemic times; outline principles to assist in the prioritization of nonpandemic research during pandemic times; and propose a guiding framework for decisions about whether, when and how to continue nonpandemic research while still honoring the moral and scientific imperative to launch research that is pandemic-focused. […] Using in-person, email, and videoconference exchanges, we convened an interprofessional clinical research group, conducted a literature review of empirical studies, ethics documents and expert commentaries (2010 to present), and viewed traditional and social media posts (March 2020 to May 2020). […] Stakeholder consultation involved scientific, ethics, clinical, and administrative leaders. […] Clinical research in the ICU. […] While clinical research should be prioritized to advantage patients with coronavirus disease 2019 in order to care for affected patients, it ideally would not unduly disadvantage patients without coronavirus disease 2019. […] Thus, timely, rigorous, relevant, and ethical clinical research is needed to improve the care and optimize outcomes for both patients with and without coronavirus disease 2019, acknowledging how many studies that are not exclusively focused on coronavirus disease 2019 remain relevant to patients with coronavirus disease 2019. | 2020-08-16 |
| 32796214 | Patients’ characteristics and median days between symptoms and diagnosis were similar by hospital admission, whereas admitted patients had lower nadir CD4 cells and current lymphocytes count. | 2020-08-16 |
| 32796217 | We studied clinical outcomes of COVID-19 infection in patients living with HIV (PLH) in comparison to non-HIV population. | 2020-08-16 |
| 32796323 | The contagious period of symptomatic cases was from 7 days before to 15 days after the onset of symptoms. | 2020-08-16 |
| 32796336 | Few studies have prospectively examined the association between physiological responses to acute psychological stress prior to a traumatic event with later PTSD symptoms. […] The present prospective study examined whether cardiovascular responses to an acute psychological stress task prior to the COVID-19 global pandemic predicted PTSD symptoms related to the ongoing pandemic. […] Hierarchical linear regression analyses were used to examine whether cardiovascular stress reactivity predicted COVID-19 PTSD symptoms. […] Diminished heart rate responses (i.e., lower physiological arousal) to acute psychological stress prior to the COVID-19 pandemic significantly predicted reported PTSD symptoms during the crisis. | 2020-08-16 |
| 32796355 | Prospective studies are needed to define the clinical relevance of liver injury in COVID-19. | 2020-08-16 |
| 32796445 | To describe our managing strategy for COVID-19 emergency, to evaluate the adherence to intravitreal treatment (AtT) rate during the outbreak in a referral hospital in Milan and to correlate it with patients clinical features. | 2020-08-16 |
| 32796683 | Indeed, we have provided the latest update on development of small molecule inhibitors, their clinical efficacy and safety as a strategy for RA treatment. | 2020-08-16 |
| 32796791 | The current study will review the psychiatric implications of COVID-19 pandemic on the general population, the bearing of social isolation, the prevention behaviours, and clinical cases of people who required psychiatric admission to hospital due to the emotional impact of COVID-19 social circumstances. | 2020-08-16 |
| 32796792 | Typical symptoms of COVID-19 infection can be very moderate (infected can be even asymptomatic) to very severe, with severe respiratory symptoms (bilateral severe pneumonia), septic schock, and fatal outcome. […] Numeous unknows regarding the biological, epidemilogical adn clinical characteristics of COVID-19, still exist, and make it impossible to predict with certainty the further course of the current pandemic. […] SARS-CoV-2 positive individuals should be evaluated in a timely manner for neurological and psychiatic symptoms because tretament of infection-related neurological and psychiatric complications is an important factor in better prognosis of severe COVID-19 patients.From the current point of view, it seems that in COVID-19 survivors, in the coming years and decades, the inflammatory systemic process and/or the inflammatory process of the brain could trigger long-term mechanisms that generally lead to an increase of neurological and neurodegenerative disorders. […] COVID-19 pandemia is associtaed with negative psychosocial consequences, including depressive symptoms, anxiety, anger and stress, sleep disorders, simpotms of posttrauamtic stres disorder, social isolation, loneliness and stigmatization. | 2020-08-16 |
| 32796796 | As a consequence psychiatrist, psychologist and mental health practitioners performed their role to mitigate the adverse impacts through its scientific and clinical lenses. | 2020-08-16 |
| 32796797 | Occurrence of symptoms of fear and depression among general population during the outbreak of COVID-19 seems to present an emerging problem worldwide. […] The aim of this study was to examine levels of fear and depressive symptoms in association with COVID-19 outbreak and to assess other contributing factors in the population of Bosnia and Herzegovina. […] Out of 1201 respondents, 217 (18.0%) reported experiencing fear and 341 (28.4%) reported having symptoms of depression during COVID-19 outbreak. […] Being older (OR=1.044; 95% CI 1.031-1.057; p<0.001) and having moderate to severe depressive symptoms (OR=1.093; 95% CI 1.067-1.120; p<0.001) were independent significant predictors for developing fear; living in rural environment (OR=0.551; 95% Cl 0.325-0.935; p=0.0027) significantly decreased the risk of developing fear; being female (OR=1.750; 95% CI 1.242-2.466; p=0.001), unemployed (OR=1.557; 95% CI 1.040-2.330; p=0.032) or student (OR=1.943; 95% CI 1.450-2.604; p<0.001) were independent significant predictors for developing moderate to severe depressive symptoms in association with COVID-19. […] Mann Whitney U-test showed that being older was statistically associated with fear (p<0.001) and being younger was statistically associated with depressive symptoms (p<0.001). […] In conclusion, based on our findings, fear and depressive symptoms in general population of Bosnia and Herzegovina during the outbreak of COVID-19 were present in 18.06% (fear) and 28.39% (depression) of subjects and it was statistically associated with age, gender, occupation, living environment and may present a secondary uprising problem connected to outbreak of COVID-19. | 2020-08-16 |
| 32796810 | BACKGROUND This population study aimed to investigate the demographic and clinical characteristics and outcome of cases of coronavirus disease 2019 in Lu’an City, China between January 22, 2020 and February 18, 2020 identified from the China Information System for Disease Control and Prevention (CISDCP). […] The distribution of cases, exposure history, clustered epidemic situation, and clinical manifestations, disease severity, and key time nodes were analyzed. […] The most common symptoms were fever (56.5%), cough (37.7%), and self-conscious discomfort (14.5%). | 2020-08-16 |
| 32796842 | This study suggests that the mucosal vaccination may provide a desirable protective efficacy and this delivery mode is worth further investigation in human clinical trials. | 2020-08-16 |
| 32796848 | Chest CT is emerging as a valuable diagnostic tool for clinical management of COVID-19 associated lung disease. […] Artificial intelligence (AI) has the potential to aid in rapid evaluation of CT scans for differentiation of COVID-19 findings from other clinical entities. | 2020-08-16 |
| 32797054 | We selected studies reporting clinical outcomes of hospitalized patients with COVID-19. […] Secondary outcomes were cardiovascular symptoms and cardiovascular events developed during the COVID-19-related hospitalization. […] Cardiovascular complications are frequent among COVID-19 patients, and might contribute to adverse clinical events and mortality, together with pre-existing cardiovascular comorbidities and RF. | 2020-08-16 |
| 32797094 | We retrospectively analyzed the results of SARS-CoV-2 RT-PCR testing according to the contact history, occupation, and presence of respiratory symptoms. […] The most common contact area was the general ward for pulmonology patients and medical support areas, including clinical and imaging examination rooms. […] Future studies are required to refine and establish the in-hospital quarantine and de-isolation guidelines based on the epidemiological and clinical settings. | 2020-08-16 |
| 32797108 | However, the requirement for serum/plasma limits serological testing to clinical settings where it is feasible to collect and process venous blood. | 2020-08-16 |
| 32797176 | International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) codes are used to characterize coronavirus disease 2019 (COVID-19)-related symptoms. […] These findings suggest that ICD-10 codes lack sensitivity and have poor NPV for symptoms associated with COVID-19. | 2020-08-16 |
| 32797188 | The clinical spectrum of COVID-19 is still not fully understood. | 2020-08-16 |
| 32797198 | This systematic review aimed to determine currently reported clinical and prodromal ocular symptoms in patients with coronavirus disease 2019 (COVID-19). […] Altogether 15 studies (retrospective, prospective, or case studies) involving 1533 patients with COVID-19, reporting on ocular symptoms, and with outcome data available were identified. […] Study-specific estimates (incidence rates of ocular symptoms in patients with COVID-19) of cases were combined using one-group meta-analysis in a random-effects model. […] Of all included studies, 11.2% (95% confidence interval, 5.5-16.9; 78/1526 cases) reported ocular symptoms. […] Prodromal ocular symptoms occurred in 12.5% (13/104 cases) of patients with COVID-19. […] Ten cases were from subjects showing ocular symptoms (16.7%, 10/60 cases), and the remaining two cases were from subjects without ocular manifestation (1.8%, 2/113 cases). […] Ocular symptoms may occur in the presymptomatic phase as a prodromal symptom (12.5%, 13/104 cases), suggesting the possibility of viral transmission from the conjunctiva. | 2020-08-16 |
| 32797228 | COVID-19 and dengue fever are difficult to distinguish given shared clinical and laboratory features. […] We analyzed clinical data and serum samples from 55 individuals with SARS-CoV-2 infection. | 2020-08-16 |
| 32797326 | Furthermore, in vitro studies suggest ibuprofen may facilitate cleavage of ACE2 from the membrane, preventing membrane-dependent viral entry into the cell, the clinical significance of which is uncertain. | 2020-08-16 |
| 32797330 | The dominant themes that were closely related to coronavirus tweets included the outbreak of the pandemic, metaphysics responses, signs and symptoms in confirmed cases, and conspiracism. | 2020-08-16 |
| 32797641 | It may be asymptomatic or cause various symptoms, ranging from flu-like symptoms to acute respiratory distress syndrome and eventually death. […] By the 18th day from the onset of symptoms, we reached an optimal diagnostic sensitivity (more than 95.0%) In fact, the diagnostic sensitivity increased over time and between 15 and 25 days after symptoms onset, reached 95.5% (95% CI = 84.9-99.2). | 2020-08-16 |
| 32797762 | Because of the specialized training in allergy and clinical immunology, and the familiarity with comorbid contributing conditions, the allergist/immunologist is uniquely poised to play a major role both in the delivery of specialized therapeutic procedures and practices that can improve the health of patients with COVID-19 as well as in the use of forthcoming vaccines for the prevention of its spread. […] This article was based on a literature review of articles published in PubMed related to COVID-19 and the immune response, and the author’s own research and clinical experiences in the field of immunology. […] Numerous clinical trials are being initiated to identify effective treatments for COVID-19 and are directed toward treatment of the two phases of infection and inflammation that influence the pathogenesis of COVID-19. | 2020-08-17 |
| 32797806 | The survey questions were designed to gain a better understanding of the effects of the current COVID-19 pandemic on the surgical and clinical experience of current, to characterize the types of supplemental educational experiences that fellowship directors had incorporated into the curriculum to compensate for the decreased surgical and clinical workload, and highlight differences based on geographic location. […] Overall, pediatric otolaryngology fellowship directors reported the COVID-19 pandemic has had a significant impact on the overall fellowship experience within the field of pediatric otolaryngology, with the majority feeling that both their fellows surgical and clinical experience have been significantly impacted. | 2020-08-17 |
| 32798002 | Kidney transplant recipients who develop symptoms consistent with coronavirus disease 2019 (COVID-19) are bringing unique challenges to health care professionals. […] While there is limited information about the duration of viral shedding for immunosuppressed patients, our findings underscore the importance of using telemedicine in the follow-up care for kidney transplant recipients with COVID-19 who have recovered from symptoms but might have persistently positive nucleic acid tests. | 2020-08-17 |
| 32798019 | The present review found that traditional Chinese herbs commonly used for the clinical treatment of organ damages caused by COVID-19, such as Scutellaria baicalensis, Salvia miltiorrhizaSalvia miltiorrhiza, and ginseng, could act on multiple signaling pathways involved in inflammation, oxidative stress and apoptosis. […] This review provides evidence and support for clinical treatment and novel drug research using TCM. | 2020-08-17 |
| 32798063 | Process-related statistics and changes in distributions of quality ratings of the highest-rated versus recommended COVID-19 era schedules were described by disease groups and for specific clinical scenarios. | 2020-08-17 |
| 32798097 | This study aimed to assess whether youth cigarette and electronic cigarette (e-cigarette) use are associated with coronavirus disease 2019 (COVID-19) symptoms, testing, and diagnosis. […] Multivariable logistic regression assessed relationships among COVID-19-related symptoms, testing, and diagnosis and cigarettes only, e-cigarettes only and dual use, sociodemographic factors, obesity, and complying with shelter-in-place. […] Symptoms were 4.7 times more likely among past 30-day dual-users (95% CI: 3.07-7.16). | 2020-08-17 |
| 32798098 | Clinical records were reviewed for all inpatients aged <18 years with laboratory-confirmed COVID-19 between March 23 and April 21, 2020. | 2020-08-17 |
| 32798115 | The clinical features do not differ from those of other respiratory viral infections, although rare cases manifest an unusual rash involving the digits. | 2020-08-17 |
| 32798154 | The survey aimed to assess changes to surgical residents’ clinical schedules, operative volume, and educational curricula as a result of the COVID-19 pandemic. […] Surgery training programs should focus on providing nontechnical clinical training and professional development during this time. | 2020-08-17 |
| 32798170 | Coronavirus disease 2019 (COVID-19) patients may show no clinical signs at the early stages of the disease or even remain asymptomatic for the whole course of the disease. […] Despite the lack of symptoms, they may be able to transfer the virus. | 2020-08-17 |
| 32798244 | Clinical follow-up of infected pregnant women and their children are needed to validate these observations. | 2020-08-17 |
| 32798248 | In contrast to SARS, some SARS-CoV-2-infected people can be asymptomatic or have only mild nonspecific symptoms. […] The overall agreement value between the SARS-CoV-2 RT-PCR assay and clinical diagnostic results was 100%. | 2020-08-17 |
| 32798300 | To identify the nursing care problems related to the clinical process of disease by COVID-19. […] The study applied the taxonomic triangulation technique on a clinical management guide to coronavirus disease, COVID-19, from the World Health Organization. | 2020-08-17 |
| 32798312 | We too have sensed the urgent need for adapting clinical, educational and scientific practice to appropriately attend to the public health crisis. | 2020-08-17 |
| 32798320 | The aim of this study is to determine how stakeholder engagement can be adapted for the conduct of COVID-19-related clinical trials in sub-Saharan Africa. […] The norms, values, and practices of collectivist societies in Sub-Saharan Africa and the low research literacy pose challenges to the conduct of clinical trials. […] Civil-society organizations, members of community advisory boards and ethics committees, young persons, COVID-19 survivors, researchers, government, and the private sector are assets for the implementation and translation of COVID-19 related clinical trials. | 2020-08-17 |
| 32798339 | It was an observational cohort study for comprehensive clinical analysis of critically ill COVID-19 patients at a dedicated COVID public hospital. | 2020-08-17 |
| 32798340 | To describe the clinical characteristics and outcomes of COVID-19 patients in Central India and to evaluate risk factors leading to requirement of oxygen, mechanical ventilation and mortality. | 2020-08-17 |
| 32798345 | One of the important clinical parameters is to identify hypoxia early to initiate higher level of care at the earliest. […] This simple tool has immense clinical applicability to ensure safe care of COVID 19 patients. | 2020-08-17 |
| 32798346 | However, “Risk Benefit Analysis” on the aspect of safety in using low molecular weight heparin (LMWH) in COVID-19 patients for thrombosis prophylaxis has been explained below with a few case studies and detailed information from various clinical evidence. | 2020-08-17 |
| 32798373 | To predict potential drugs for COVID-19 by using molecular docking for virtual screening of drugs approved for other clinical applications. […] List of drugs approved for clinical use was obtained from SuperDRUG2 database. […] Data regarding drugs in clinical trials for COVID-19 was obtained from clinicaltrials.org. […] Among the drugs that are being tested in clinical trials for COVID-19, Danoprevir and Darunavir have the highest binding affinity for the target main protease of SARS-CoV-2. […] Saquinavir and Beclabuvir were identified as the best novel candidates for COVID-19 therapy by using Virtual Screening of drugs approved for other clinical indications. | 2020-08-18 |
| 32798444 | Multiple SARS-CoV-2 vaccine candidates have been evaluated in preclinical models and are currently in clinical trials. […] In this Perspective, we discuss three topics that are critical for SARS-CoV-2 vaccine development: antigen selection and engineering, preclinical challenge studies in non-human primate models, and immune correlates of protection. | 2020-08-18 |
| 32798468 | Patients with COVID-19 who develop severe acute respiratory distress syndrome (ARDS) can have symptoms that rapidly evolve to profound hypoxaemia and death. […] We aimed to establish the clinical characteristics and outcomes of patients with respiratory failure and COVID-19 treated with ECMO. | 2020-08-18 |
| 32798659 | Clinical trials are urgently needed to evaluate the roles of prophylactic and therapeutic anticoagulation in COVID-19. | 2020-08-18 |
| 32798701 | The purpose of this study was to assess clinical characteristics and risk factors for mortality of patients with coronavirus disease 2019 (COVID-19) from Mexico, given that it currently is in active community transmission. […] Hospitalized patients and those with pneumonia had serious risks for mortality (P < .0001), and more attention to specific conditions might be considered during clinical admission. | 2020-08-18 |
| 32798764 | Human placenta has been used in clinical practice for over a century and there is substantial experience in clinical applications of placental extract for different indications. […] Executing a clinical trial using placental extract as preventive, protective and/or therapeutic approach for COVID-19treatment could advance the development of a most promising therapeutic candidate that can join the armamentaria against the COVID-19 virus. | 2020-08-18 |
| 32798769 | In lack of clear clinical evidences for the pathogenesis of COVID-19, comparative analysis of previous pandemic HCoVs associated immunological responses can provide insights into COVID-19 pathogenesis. […] We also consider the host immune response and viral evasion based on available clinical evidences which would be helpful to remodel COVID-19 pathogenesis; and hence, development of therapeutics against broad spectrum of coronaviruses. | 2020-08-18 |
| 32798855 | The coronavirus disease 2019 (Covid-19) pandemic has led to challenges in provision of care, clinical assessment and communication with families. | 2020-08-18 |
| 32798922 | In a multicenter clinical trial, we evaluated the performance of a machine learning algorithm for prediction of invasive mechanical ventilation of COVID-19 patients within 24 h of an initial encounter. […] We enrolled patients with a COVID-19 diagnosis who were admitted to five United States health systems between March 24 and May 4, 2020. 197 patients were enrolled in the REspirAtory Decompensation and model for the triage of covid-19 patients: a prospective studY (READY) clinical trial. […] In the first clinical trial of a machine learning algorithm for ventilation needs among COVID-19 patients, the algorithm demonstrated accurate prediction of the need for mechanical ventilation within 24 h. | 2020-08-18 |
| 32798931 | To investigate the effects of COVID-19 pandemic and related home confinement on symptom profile, symptom severity and exacerbation of obsessive compulsive disorder (OCD) symptoms and related factors among young subjects with OCD. […] Children’s Yale-Brown Obsessive Compulsive (CY-BOCS) and Clinical Global Impression- Severity (CGI-S) Scales were used to rate symptom profile and severity before pandemic and during pandemic periods. […] Young subjects with OCD may develop additional symptoms and worsen already existing symptoms of OCD during COVID-19 pandemic. | 2020-08-18 |
| 32799105 | Relatively high rates of symptoms of anxiety (6.33% to 50.9%), depression (14.6% to 48.3%), post-traumatic stress disorder (7% to 53.8%), psychological distress (34.43% to 38%), and stress (8.1% to 81.9%) are reported in the general population during the COVID-19 pandemic in China, Spain, Italy, Iran, the US, Turkey, Nepal, and Denmark. […] The COVID-19 pandemic is associated with highly significant levels of psychological distress that, in many cases, would meet the threshold for clinical relevance. | 2020-08-18 |
| 32799107 | Psychological distress clusters were determined using latent profile analysis on a wide-range of symptoms using the complete Brief-Symptom Inventory-53. […] Participants reported elevated symptoms of Phobic-Anxiety (41.3%), Anxiety (31.8%), Depression (27.5%), General-Distress (27.1%), Obsession-Compulsion (25.1%) and Hostility (13.7%). | 2020-08-18 |
| 32799178 | The other two patients survived but symptoms of paralysis and aphasia persisted after cerebral ischemia due to large vessel arterial thromboembolism. | 2020-08-18 |
| 32799179 | Clinical data were extracted from medical records. […] Thrombotic complications are commonly found and merit clinical attention. | 2020-08-18 |
| 32799197 | In this retrospective, single-center cohort study, we describe the clinical courses of 6 preterm infants born to COVID-19 mothers, the management protocol, and related outcomes. | 2020-08-18 |
| 32799213 | The patient described in this report is unique for acute-onset and isolated cognitive impairments due to SARS-CoV-2 infection in the absence of clinical or radiological respiratory manifestations. | 2020-08-18 |
| 32799217 | CASE REPORT A 64-year-old male with end-stage renal disease and post renal transplant presented with severe respiratory symptoms of COVID-19 and was intubated upon admission. […] This coincided with and most likely resulted in the patient’s clinical deterioration and ultimate death. | 2020-08-18 |
| 32799318 | To assess clinical impact, psychological effects, and knowledge of pregnant women during the COVID-19 outbreak in seven cities in Colombia. […] The questions evaluated demographic, knowledge, psychological symptoms, and attitudes data regarding the COVID-19 pandemic. […] The rate of psychological consequences of the pandemic was much larger than the number of patients clinically affected by the virus, with 50.4% of the entire cohort reporting symptoms of anxiety, 49.1% insomnia, and 25% reporting depressive symptoms. | 2020-08-18 |
| 32799322 | According to the latest literature, most patients with COVID-19 have mild symptoms that do not require hospital admissions, and only a small percentage of those hospitalized require intensive care. | 2020-08-18 |
| 32799337 | We aimed to establish the impact of this pandemic on epilepsy patients in terms of patient-reported seizure control and emerging symptoms. […] Demographic and clinical characteristics were recorded, and a 19-item questionnaire was systematically completed. […] Additional clinical data were obtained in patients with a COVID-19 diagnosis. | 2020-08-18 |
| 32799381 | To describe clinical characteristics of pregnant and postpartum women with severe COVID-19 in Brazil and to examine risk factors for mortality. […] Data on demographics, clinical characteristics, intensive care resources use and outcomes were collected. […] Negative outcomes of COVID-19 in this population are affected by clinical characteristics but social determinants of health also seem to play a role. […] Symptoms onset at postpartum and comorbidities are risk factors. | 2020-08-18 |
| 32799392 | We herein analyzed the clinical data on patients in whom KD was diagnosed during a local COVID-19 epidemic to investigate the relationship between KD and SARS-CoV-2 infections in Japan, which has the highest KD incidence in the world. | 2020-08-18 |
| 32799566 | Multi-drug therapy by targeting different pathways will need to be corroborated and then confirmed through clinical trials. […] Until a vaccine is available, an alternative drug regimen needs to be adopted by clinicians in the management of coronavirus symptoms. | 2020-08-18 |
| 32799618 | The analytical performance and clinical evaluation of this testing method was done and the clinical significance of the testing method was verified. […] The SARS-CoV-2 antibody test strip can provide rapid, flexible and accurate testing, and is able to meet the clinical requirement for rapid on-site testing of virus. […] The ability to detect IgM and IgG provided a significant benefit for the detection and prediction of clinical course with COVID-19 patients. | 2020-08-18 |
| 32799694 | We reviewed the application of rehabilitation therapy in the clinical treatment of COVID-19 patients. | 2020-08-18 |
| 32799852 | Hypertension is the most frequent co-morbidity in patients with covid-19 infection, and we might speculate that a specific blood group could play a key role in the clinical outcome of hypertensive patients with covid-19. | 2020-08-18 |
| 32799883 | Our core idea is that “active cancer” may be considered a proxy of more recent exposure to diagnostic or therapeutic procedures, and the frequency of access to health care facilities can be predicted as a function of the severity of cancer symptoms. | 2020-08-18 |
| 32799894 | Though the majority of symptomatic patients have mild flu-like symptoms, a significant minority develop severe lung injury with acute respiratory distress syndrome (ARDS), leading to considerable morbidity and mortality. […] Elderly patients with previous cardiovascular comorbidities are particularly susceptible to severe clinical manifestations. […] Although the clinical presentation of this disease is fairly well characterized, knowledge of the pathologic aspects remains comparatively limited. […] In this review, we discuss clinical, pathologic, and genomic features of COVID-19, review current hypotheses regarding the pathogenesis, and briefly discuss the clinical characteristics. | 2020-08-18 |
| 32800031 | To systematically summarize the clinical features of coronavirus disease 2019 (COVID-19) in children. […] PubMed, Embase, Web of Science, The Cochrane Library, CNKI, Weipu Database, and Wanfang Database were searched for clinical studies on COVID-19 in children published up to May 21, 2020. […] The children with COVID-19, SARS, and MERS had similar clinical symptoms, mainly fever and cough. […] Some children had gastrointestinal symptoms. […] Children with COVID-19 have similar symptoms to those with SARS or MERS, mainly fever and cough. | 2020-08-18 |
| 32800044 | This review describes the physiological rationale behind CPAP therapy for patients with COVID-19 and the clinical experience with CPAP, implemented in a medical ward without prior knowledge of the treatment. | 2020-08-18 |
| 32800063 | The aim of this study was to describe the clinical symptoms, including affection of sense of smell and taste, among participants in a party held in Copenhagen after which many participants reported symptoms compatible with coronavirus disease 2019 (COVID-19). […] The questionnaire included questions about the type, timing and duration of COVID-19 symptoms. […] In total, 65 of 95 (68%) participants responded, among whom 51/65 (78%) had symptoms compatible with COVID-19; 53% (27/51) had affection of their sense of smell and taste; 70% (19/27) reported a total loss of taste. […] These symptoms continued for 1-3 weeks for 78% and 3-6 weeks for 22% (6/27). […] The duration of these symptoms currently remains unknown. none. not relevant. | 2020-08-18 |
| 32800064 | A questionnaire was sent out to parents in four municipalities consisting of 20 questions about frequency of hand washing, use of hand sanitiser, symptoms of ICD, atopic dermatitis, allergy and predispositions. […] In children without any prior symptoms of dermatitis, 42.4% experienced ICD (dry, red and itchy skin) due to increased hand hygiene. | 2020-08-18 |
| 32800066 | Clinical data, treatment and outcome were analysed in this retrospective study of 101 consecutive patients with COVID-19 admitted to a regional Danish hospital from 2 March 2020, based on data from electronic medical records. […] COVID-19-related symptoms were initially observed from February 21 (week 8 and week 9) in the first three patients who had no known source of infection. | 2020-08-18 |
| 32800070 | During the first 24 days, a total of 3,551 patients were referred for assessment of symptoms of upper respiratory tract infection and COVID-19. […] A total of 2,048 patients were assessed as having mild symptoms and referred for COVID-19 testing alone, whereas 337 patients were assessed clinically by a physician. […] The most common symptoms reported were fever, coughing and dyspnoea. […] In total, 113 patients were admitted to hospital, the majority of patients were discharged within 24 hours with mild symptoms of upper respiratory tract infections. | 2020-08-18 |
| 32800073 | Limited data are available describing the clinical presentation and outcomes of hospitalised COVID-19 patients in Europe. | 2020-08-18 |
| 32800093 | Since a shorter doubling-time for the number of infectious persons by only 5% would result in a major clinical emergency, interventional measures such as vaccination are urgently needed. | 2020-08-18 |
| 32800295 | However, limited information describing their clinical characteristics and outcomes exists. […] Our study aims to describe clinical features and risk stratification strategies of hospitalized COVID-19 patients with PE. […] Clinical outcomes measured were intensive care unit admission, mechanical ventilation, bleeding and transfusion events, acute kidney injury (AKI) and mortality. […] PESI scores were utilized for risk stratifying clinical outcomes. | 2020-08-18 |
| 32800347 | However, delirium is expected to be a more likely etiology of neuropsychiatric symptoms in critically ill patients treated for coronavirus disease-2019, and adjustment disorder is a much more likely etiology of anxiety and depression symptoms than the side effects of chloroquine or hydroxychloroquine. | 2020-08-18 |
| 32800430 | We discuss the pathophysiological mechanisms underlying this association as well as its possible clinical implications as a marker of disease severity in COVID-19. | 2020-08-18 |
| 32800516 | We also review 10 similar cases found in the literature and describe the clinical course and management, including immunosuppressive therapy. | 2020-08-18 |
| 32800517 | The test is neither 100% sensitive nor specific for rejection; however, when used in combination with the available clinical information, it can be used for determining whether bringing in a transplant recipient into a medical facility is necessary. | 2020-08-18 |
| 32800622 | The clinical course of COVID-19 critically ill patients, during their admission in the intensive care unit (UCI), including medical and infectious complications and support therapies, as well as their association with in-ICU mortality has not been fully reported. […] This study aimed to describe clinical characteristics and clinical course of ICU COVID-19 patients, and to determine risk factors for ICU mortality of COVID-19 patients. […] Demographics, symptoms, vital signs, laboratory markers, supportive therapies, pharmacological treatments, medical and infectious complications were reported and compared between deceased and discharged patients. | 2020-08-18 |
| 32800699 | Meta-analysis showed that the overall clinical effectiveness (OR = 2.67, 95% CI 1.83-3.89, I2 = 0%), improvement in the CT scan (OR = 2.43, 95% CI 1.80-3.29, I2 = 0%), percentage of cases turning to severe/critical (OR = 0.40, 95% CI 0.24-0.67, I2 = 17.1%), reverse transcription-polymerase chain reaction (RT-PCR) negativity rate (OR = 2.55, 95% CI 1.06-6.17, I2 = 56.4%) and disappearance rate of symptoms (fever, cough, and fatigue) were superior by combined CHM treatment of COVID-19. […] The combined treatment of COVID-19 with Chinese and Western medicine may be effective in controlling symptoms and reducing the rate of disease progression due to low quality evidence. | 2020-08-18 |
| 32800720 | The aim of our study is to analyse the impact on emergency medicine attendance after the national lockdown, as well as the clinical presentation and the management of patients with suspected COVID-19 in the Paediatric Emergency Department. […] Most frequent reasons for consultation at the Paediatric Emergency Department were fever (26.5%), respiratory symptoms (16.1%), and trauma (15.2%). […] Most of the patients with suspected or microbiological confirmation of COVID-19 had mild respiratory symptoms. | 2020-08-18 |
| 32800855 | In routine clinical practice, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is determined by reverse-transcription PCR (RT-PCR). | 2020-08-18 |
| 32800857 | We explored the effects of the expanded screening criteria which allow clinicians to isolate and investigate patients presenting with undifferentiated fever or respiratory symptoms or chest x-ray abnormalities. | 2020-08-18 |
| 32800858 | A SRL was performed in PubMed and Embase, searching terms corresponding to the ‘PEO’ format: population = adult patients affected with COVID-19; exposure = gender; outcome = any available clinical outcomes by gender, including mortality and disease severity. | 2020-08-18 |
| 32800868 | This review describes useful strategies in clinical practice, including a systematic assessment of addiction comorbidity during this almost worldwide lockdown/pandemic. | 2020-08-18 |
| 32801323 | Objective Evaluation of patient experience when utilising teledentistry during the coronavirus (COVID-19) pandemic.Methods We designed a ten-item, five-point Likert-scale questionnaire assessing: 1) patient satisfaction; 2) ease of use; 3) the effectiveness including increasing access to clinical services; 4) reliability of the teledentistry system; and 5) usefulness for patients. | 2020-08-18 |
| 32801369 | Specific airborne infection with characteristic symptoms - high fever, headache, persisting dry cough, loss of taste and smell and overall tiredness originates from Wuhan in China where it was discovered in December 2019. | 2020-08-18 |
| 32801413 | After an incubation period of about two days to two weeks, a spectrum of clinical manifestations can be seen in individuals afflicted by COVID-19: from an asymptomatic condition that can spread the virus in the environment, to a mild/moderate disease with cold/flu-like symptoms, to deteriorated conditions that need hospitalization and intensive care unit management, and then a fatal respiratory distress syndrome that becomes refractory to oxygenation. […] Several diagnostic modalities have been advocated and evaluated; however, in some cases, diagnosis is made on the clinical picture in order not to lose time. | 2020-08-18 |
| 32801428 | In addition, we do not have a single clinical study that would support prophylactic therapy that could affect COVID-19. | 2020-08-18 |
| 32801630 | Information on participants’ socio-demographic characteristics, knowledge of clinical features of COVID-19, risk assessment and infection control measures for preventing disease transmission, and attitude towards treating patients with COVID-19 were collected. […] Most ophthalmologists were aware of COVID-19 symptoms and ways to identify patients at risk of having the disease, correctly reported modes of transmission and were aware of measures for preventing COVID-19 transmission in the ophthalmic setup. | 2020-08-18 |
| 32801640 | Here, we reviewed the literature on clinical effects in COVID-19 patients of these antiviral agents and provided the potential antiviral agent options for pregnant women, elderly patients, liver or renal dysfunction patients, and severe or critically ill patients receiving renal replacement therapy or ECMO after SARS-CoV-2 infection. | 2020-08-18 |
| 32801727 | Although this class of therapy has demonstrated impressive clinical efficacy against cancers that were once thought to be incurable, its success is in part limited by unique toxicities which can be severe or even fatal. […] Here, we review the use of tocilizumab in the management of CAR-T-associated CRS, emphasizing on the clinical efficacy across various CAR constructs and its role in current CRS management algorithms. | 2020-08-18 |
| 32801787 | The clinical presentation of severe patients resembles viral-associated hemophagocytic syndrome, a rare condition previously seen during lethal influenza pandemics and during previous SARS and MERS coronavirus outbreaks. | 2020-08-18 |
| 32801798 | Medical records and laboratory data were extracted and combined for COVID-19 and other pulmonary infection patients on admission. | 2020-08-18 |
| 32801800 | The purpose of this study was to identify the common clinical presentations and the evidence on the presence of ageusia and anosmia as an emerging coronavirus disease 2019 (COVID-19) symptom to better inform in both COVID-19 patients and clinicians. […] As part of a double-institutional collaboration coordinated by doctors, this study retrospectively collected and analyzed the clinical characteristics of 60 patients with COVID-19 pneumonia between April 1 and April 20, 2020. […] The most common symptoms at the onset of illness were cough (75%), fever (71.3%), myalgia or fatigue (53.3%), anosmia (loss of smell) (40%), ageusia (loss of taste) (28.3%), sore throat (25%), shortness of breath (16.7%), headache (16.7%), and GI symptoms (diarrhea, nausea, vomiting and loss appetite) (16.7%). | 2020-08-18 |
| 32801803 | Despite the worldwide spread of the coronavirus disease 2019 (COVID-19), the epidemiological and clinical patterns of the COVID-19 infection remain largely unclear, particularly among children. […] In this study, we explored the epidemiological characteristics, clinical patterns, and laboratory and imaging findings of pediatric patients with COVID-19. […] Information recorded included demographic data, medical history, exposure history, underlying comorbidities, symptoms, signs, laboratory findings and radiologic assessments, severity of disease, treatment, and mortality. […] This study demonstrates different clinical findings of pediatrics compared to the previous reports of children. | 2020-08-18 |
| 32801886 | In this framework, prioritization is a key concept based on the severity of symptoms and the need for urgent (surgical) intervention. | 2020-08-18 |
| 32801943 | Although liver injury is common in patients with COVID-19, little is known about its clinical presentation and management in liver transplantation. […] This is the first report from Iran that presented two cases of liver transplantation with COVID-19, neither of which had pulmonary signs and symptoms, but after diagnostic imaging, both had lung involvement. | 2020-08-18 |
| 32801956 | Furthermore, we found the symptoms of clinically significant post-traumatic stress in 1160 (27.7%) of the participants. […] During phase 2 of the COVID-19 outbreak in Mexico, we observed the presence of psychological distress and post-traumatic stress symptoms in over a quarter of the population. | 2020-08-18 |
| 32802142 | A multicentre retrospective study of demographic, clinical, laboratory and immunological features of 584 Spanish COVID-19 hospitalized patients and their outcomes was performed. […] Our cases are older than those so far reported and the clinical course of the disease is found to be impaired by age. | 2020-08-18 |
| 32802146 | Based on available published evidence and clinical practice, diagnostic tests of coronavirus disease (COVID-19) were evaluated by multi-criteria decision-making (MCDM) methods, namely, fuzzy preference ranking organization method for enrichment evaluation (fuzzy PROMETHEE) and fuzzy technique for order of preference by similarity to ideal solution (fuzzy TOPSIS). | 2020-08-18 |
| 32802219 | We retrospectively analyzed the clinical data of COVID-19 patients who were cured and discharged from the Public Health Treatment Center of Changsha from January 30, 2020, to February 19, 2020. […] According to the clinical classification of the disease, the patients were divided into severe and nonsevere groups. […] General clinical data and underlying medical conditions were recorded through the electronic medical record (EMR) system. | 2020-08-18 |
| 32802325 | We discuss current evidence about the cardiovascular involvement during COVID-19, and elaborate on clinical implications in elderly patients. | 2020-08-18 |
| 32802428 | The hood, named Barrihood, was found to be competent to be used (I) for tracheal suctioning in ICU, (II) as a waiting space for a child in a nursery who suddenly showed symptoms of the disease and waiting to be picked-up by the guardian, and (III) as a waiting space in a special outpatient clinic in a hospital for COVID-19 suspected cases to prevent dissemination of airborne pathogens. | 2020-08-18 |
| 32802446 | Her father (Patient 1) developed a fever and respiratory system symptoms and was confirmed COVID-19-positive on February 4-5, 2020 at Zengcheng People’s Hospital, Guangzhou, China. […] Except for Patient 1, who had fever, cough, fatigue, and dizziness, the remaining four (4/5, 80%) COVID-19-positive family members (Patients 2-5) had no clinical symptoms. […] CT screening is necessary in close-contact family members of a confirmed COVID-19 pneumonia case, regardless of the presence of clinical symptoms. | 2020-08-18 |
| 32802523 | Her clinical course exhibited complications, including pulmonary embolism, acute kidney injury, pneumothorax, pneumomediastinum, multiple cardiac arrests, and eventually death. | 2020-08-18 |
| 32802586 | Neurological manifestations are being reported in patients with COVID-19 but clinical guidelines and effective treatments remain unclear. | 2020-08-18 |
| 32802606 | She was managed symptomatically, and improvement in her clinical condition was observed and was discharged with outpatient follow-up. […] Although acute pancreatitis is rare in patients with COVID-19, it should be considered as a differential diagnosis in patients with severe epigastric pain and respiratory symptoms. | 2020-08-18 |
| 32802622 | Objective The goal of this retrospective study is to describe the clinical outcomes of high-risk COVID-19 patients with moderate to severe symptoms in LTCFs after early intervention with DOXY. […] Exposure All patients who were diagnosed with COVID-19 received DOXY and regular standard of care within 12 hours of the onset of symptoms. […] Eighty-five percent (85%) of patients (n=76) demonstrated clinical recovery that is defined as resolution of fever (average 3.7 days, Coeff = -0.96, p = 0.0001), resolution of SOB (average 4.2 days), and improvement of POX: average 84% before treatment and average 95% after treatment (84.7 ± 7% vs. […] Within 10 days of symptom onset, 3% of patients (n=3) were transferred to hospital due to clinical deterioration and 11% of patients (n=10) died. […] The result was followed for 30 days from the onset of symptoms in each patient. […] Conclusion Early treatment with DOXY for high-risk patients with moderate to severe COVID-19 infections in non-hospital settings, such as LTCFs, is associated with early clinical recovery, decreased hospitalization, and decreased mortality. | 2020-08-18 |
| 32802627 | Clinical and laboratory patient data were collected. | 2020-08-18 |
| 32802693 | Humanitas Clinical and Research Hospital (Rozzano, MI, Italy) was declared a regional hub for the treatment of COVID-19 patients. | 2020-08-18 |
| 32802743 | Healthcare simulation training enhanced healthcare workers’ personal strengths critical to operational and clinical outcomes during the COVID-19 pandemic. | 2020-08-18 |
| 32802744 | Five research topics were identified: Data mining method based analysis on the medication law of Chinese medicine in prevention and management of COVID-19; exploration of active compounds of Chinese medicine for COVID-19 treatment based on network pharmacology and molecular docking; expert consensus and interpretation of COVID-19 treatment; research on the etiology and pathogenesis of COVID-19; and clinical research of TCM for COVID-19 treatment. | 2020-08-18 |
| 32802745 | This work was a retrospective review of medical records on patients who received at least one telemedicine session from March 9, 2020 to April 12, 2020 provided by the COVID-19 telemedicine center of Korean Medicine. | 2020-08-18 |
| 32802747 | There are similar symptoms and laboratory findings with both dengue fever and COVID-19, paving way to dangerous possibilities such as incorrect or delayed initial treatment. […] We present cases of patients who initially presented with symptoms and laboratory findings of dengue fever, including positive NS1 and/or IgM serology results. […] During the course of illness these patients fail to show characteristic dengue symptoms, and two cases begin to show respiratory symptoms. […] These cases highlight the importance of comprehensively studying patients with apparent dengue fever symptoms and serology, and using the appropriate adjuvant test according to the course of the disease, since a serological overlap may exist between the two diseases. | 2020-08-18 |
| 32802908 | Considering the hospital-based education, clinical mentors, and students in all health professions are potential carriers. […] Maintaining standard in medical education, keeping the clinical learning on stream, and minimizing the assessment disruption are unprecedented challenges under pandemic conditions. […] In this commentary, the author highlights the importance of virtual education and the potential implications of integrating virtual simulation technologies into medical education for the future of clinical competency learning and assessment. | 2020-08-18 |
| 32802924 | Regardless of their clinical use, their manipulation is necessary since the pure drug substance is not always promptly available and most of the drug products available on the market are tablets designed to be ingested; no liquid dosage forms are available. | 2020-08-18 |
| 32802926 | When deciding the optimal timing for total hip arthroplasty in patients with COVID-19, we recommend using inflammatory markers, such as procalcitonin and interleukin-6, as indicators of disease resolution and caution operative intervention when patients are nearing the 7-10th day of COVID-19 symptoms. | 2020-08-18 |
| 32802963 | Any individuals screening positive are invited to a clinical screen, potential test and referral to necessary care - conducted in-person near their home following careful risk minimization procedures. | 2020-09-02 |
| 32802967 | We argue that predictions of a ‘tsunami’ of mental health problems as a consequence of the pandemic of coronavirus disease 2019 (COVID-19) and the lockdown are overstated; feelings of anxiety and sadness are entirely normal reactions to difficult circumstances, not symptoms of poor mental health. | 2020-08-18 |
| 32803133 | In this Consensus Statement, the Panel addresses questions related to treatment initiation, preferred therapies, minimizing visit to clinics and infusions centers, supportive care and guidance for WM patients in clinical trials. | 2020-08-18 |
| 32803231 | Although the clinical manifestations of COVID-19 are dominated by respiratory symptoms, some patients present other severe damage such as cardiovascular, renal and liver injury or/and multiple organ failure, suggesting a spread of the SARS-CoV-2 in blood. […] Fifty-eight consecutive COVID-19 patients with pneumonia 8 to 12 days after onset of symptoms and 12 healthy controls were analyzed. […] Among nine patients who experienced clinical deterioration during follow-up, eight had positive SARS-CoV-2 RNAaemia at baseline while only one critical patient with undetectable SARS-CoV-2 RNAaemia at the time of analysis died at day 27. | 2020-08-18 |
| 32803236 | Baseline clinical and epidemiological information of SARS-CoV-2 RT-PCR confirmed cases detected between March 17th-May 4th in the San Pedro Sula Metropolitan area was collected, and, for hospitalized cases, clinical data was abstracted. | 2020-08-18 |
| 32803237 | Case-patients included both clinical and non-clinical roles, with nearly half (49.4%) of positive HCWs being nurses. | 2020-08-18 |
| 32803251 | This initiative supports seven clinical trials designed to systematically test and/or develop and test adaptations of evidence-based smoking cessation interventions for PWH (e.g., combination of behavioral and pharmacological). | 2020-08-18 |
| 32803387 | Myocardial involvement due to SARS-CoV-2-infection was highly prevalent in the present cohort-even in patients with mild symptoms. | 2020-08-18 |
| 32803422 | Here, we present a narrative review of cases reported in literature and we discuss the clinical acute and follow-up management of these patients. […] Patients with SARS-Cov-2-associated multisystem inflammatory syndrome frequently presented with persistent fever, gastrointestinal symptoms, polymorphic rash, conjunctivitis, and mucosal changes. […] What is New: • Patients with MIS-C often present with fever, gastrointestinal symptoms, and shock. | 2020-08-18 |
| 32803468 | Future studies are required to determine methods to improve the tolerability of awake prone positioning and whether there is an impact on clinical outcomes. | 2020-08-18 |
| 32803484 | Data regarding clinical characteristics and laboratory findings were obtained from electronic medical records. | 2020-08-18 |
| 32803531 | Swab use is also outlined, and the early information regarding clinical use is described, including an ongoing multicenter trial methodology. | 2020-08-18 |
| 32803716 | There is a paucity of data on the clinical presentations and outcomes of Corona Virus Disease-19 (COVID-19) in patients with underlying liver disease. […] The clinical presentations included complications of cirrhosis in 12 (46.2%), respiratory symptoms in 3 (11.5%), and combined complications of cirrhosis and respiratory symptoms in 11 (42.3%) patients. […] Both non-cirrhotic patients presented with respiratory symptoms and recovered uneventfully. | 2020-08-18 |
| 32803988 | After the high impact of the pandemic, a wide clinical spectrum of late complications associated with COVID-19 are being observed. […] Severe C. difficile-associated colitis is diagnosed according to clinical features and CT findings. […] The appearance of late digestive symptoms in patients diagnosed and treated for COVID-19 should alert clinicians to the possibility of C. difficile infection. | 2020-08-18 |
| 32804055 | As the COVID-19 hospital census increased to peak levels, the most value was added through facilitation of communication and collaboration between the bedside clinical teams, the infection prevention and control teams, and patient logistics team. | 2020-08-18 |
| 32804081 | Temporal inference from laboratory testing results and triangulation with clinical outcomes extracted from unstructured electronic health record (EHR) provider notes is integral to advancing precision medicine. | 2020-08-18 |
| 32804086 | Rapid access to evidence is crucial in times of an evolving clinical crisis. […] To that end, we propose a novel approach to answer clinical queries, termed rapid meta-analysis (RMA). […] We aimed to evaluate whether RMA can generate meaningful clinical insights, but crucially, in a much faster processing time than traditional meta-analysis, using a relevant, real-world example. […] The development of our RMA approach was motivated by a currently relevant clinical question: is ocular toxicity and vision compromise a side effect of hydroxychloroquine therapy? […] By combining AI with human analysis in our RMA, we generated a meaningful, clinical result in less than 30 minutes. […] We demonstrate that a novel approach to meta-analysis using AI can generate meaningful clinical insights in a much shorter time period than traditional meta-analysis. | 2020-08-18 |
| 32804094 | Since it is unclear whether AD patients are prone to COVID-19 infection and progression to severe stages, we report for the first time a retrospective analysis of the clinical characteristics of AD patients with COVID-19 pneumonia. […] We conducted a retrospective cohort study of the clinical data of 19 AD patients with COVID-19 pneumonia, compared with 23 non-AD COVID-19 patients admitted at the same time to our hospital. […] Demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. | 2020-08-18 |
| 32804112 | To retrospectively analyze and stratify the initial clinical features and chest CT imaging findings of patients with COVID-19 by gender and age. […] The clinical manifestations, laboratory examination and chest CT imaging features were analyzed, and a stratification analysis was performed according to gender and age [younger group: <50 years old, elderly group ≥50 years old]. […] The main clinical complaints are fever (54%) and cough (46%). […] Subgroup analysis showed that there was no difference in the gender distribution of all the clinical and imaging features. […] COVID-19 has various clinical and imaging appearances. | 2020-08-18 |
| 32804113 | This study aims to employ the advantages of computer vision and medical image analysis to develop an automated model that has the clinical potential for early detection of novel coronavirus (COVID-19) infected disease. […] This study demonstrated that a deep transfer learning is feasible to detect COVID-19 disease automatically from chest X-ray by training the learning model with chest X-ray images mixed with COVID-19 patients, other pneumonia affected patients and people with healthy lungs, which may help doctors more effectively make their clinical decisions. | 2020-08-18 |
| 32804258 | We found many reports of deteriorations in symptoms, and of impacts of loneliness and social isolation and of lack of access to services and resources, but sometimes also of resilience, effective self-management and peer support. | 2020-08-18 |
| 32804317 | Demographic and clinical data, comorbidities, outcomes and laboratory findings were obtained. […] Our study demonstrates that patients with COVID-19 and diabetes tend to have more severe disease and poorer clinical outcomes. | 2020-08-18 |
| 32804431 | Nine additional patients either met the definition of suspect case or presented with at least two of the most common symptoms of SARS-CoV-2 infection. […] None of the patients treated with mTOR inhibitors for their underlying comorbidities was diagnosed with COVID-19, and those who showed suspicious respiratory symptoms recovered fully. | 2020-08-18 |
| 32804456 | In each case, a treatment decision must be reached based on best clinical practices for the disorder, patient comorbidities, the current state of knowledge about the pathogenesis and infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the utilization of hospital and community resources. | 2020-08-18 |
| 32804580 | Quantitative clinical characteristics and laboratory values were compared between groups. | 2020-08-18 |
| 32804611 | Whether glucocorticoid treatment is associated with changes in mortality or mechanical ventilation in patients with high or low CRP needs study in prospective, randomized clinical trials. | 2020-08-18 |
| 32804669 | We compared demographical and clinical characteristics, rate of intravenous and endovascular therapies and therapeutic time parameters of acute ischemic strokes admitted to a university stroke centre in a COVID-epidemic period (01/03/2020-30/04/2020) and an identical period of 2019. 86 patients were admitted during the COVID-period and 97 in the control period. […] Demographical and clinical characteristics of these periods were well-balanced. | 2020-08-18 |
| 32804682 | Patients that received a high dose of vitamin D supplementation achieved normalization of vitamin D levels and improved clinical recovery evidenced by shorter lengths of stay, lower oxygen requirements, and a reduction in inflammatory marker status. […] Randomized clinical trials will serve as an appropriate vessel to validate the efficacy of the therapeutic regimen and dissection of the pathway. | 2020-08-18 |
| 32804703 | A tiered patient identification and clinical messaging referral system was developed. | 2020-08-18 |
| 32804747 | Multivariable logistic regression analysis was used to identify factors associated with mental health symptoms. […] Nurses lacking access to adequate PPE (24.9%, n = 163) were more likely to report symptoms of depression (OR 1.96, 95% CI 1.31, 2.94; p = .001), anxiety (OR 1.64, 95% CI 1.12, 2.40; p = .01) and post-traumatic stress disorder (OR 1.83, 95% CI 1.22, 2.74; p = .003). | 2020-08-18 |
| 32804760 | We describe the results of F-FDG PET/CT of 3 patients referred to our institution during the single day of Monday, March 23, 2020, for an initial assessment of cancer extension or for the therapeutic evaluation of chemotherapy of neoplastic pathology, with no obvious infectious or respiratory symptoms at the time of examination. […] A retrospective review of the recent clinical history of patients in association with the typical pulmonary images on CT scan suggested the diagnosis of COVID-19. | 2020-08-18 |
| 32804787 | Eight patients with clinical myoclonus in the setting of coronavirus disease 2019. | 2020-08-18 |
| 32804790 | We examined the impact of time to intubation and use of high-flow nasal cannula on clinical outcomes in patients with coronavirus disease 2019. | 2020-08-18 |
| 32804792 | The outcomes reported in trials in coronavirus disease 2019 are extremely heterogeneous and of uncertain patient relevance, limiting their applicability for clinical decision-making. […] “Distinguishing overlap, correlation and collinearity” meant recognizing that symptoms such as shortness of breath had distinct value and minimizing overlap (e.g. lung function and pneumonia were on the continuum toward respiratory failure). | 2020-08-18 |
| 32804802 | We describe clinical pictures, risk factors for death and chances to recovery in a large cohort of KT recipients with COVID-19. […] Fever, respiratory symptoms and dyspnea were the most frequent COVID-19 related symptoms, and 81.4% of them had pneumonia. […] More than one-third of patients showed digestive symptoms at diagnosis, combinations of nausea, vomiting and diarrhea. […] Pneumonia without gastrointestinal symptoms was associated with a 36.3% mortality (Respiratory phenotype), and gastrointestinal symptoms without pneumonia with a 5.3% mortality (Gastrointestinal phenotype). […] Advanced age and pneumonia are the main clinical features associated with a high mortality rate. | 2020-08-18 |
| 32804917 | Large controlled clinical trials are required to study the efficacy and safety of using O₂-O₃ therapy compared with the standard supportive case in patients with COVID-19 in terms of the need for invasive ventilation and length of hospital and intensive care unit stays. | 2020-08-18 |
| 32804920 | There are limited reports of neurological symptoms in the pediatric population with COVID-19. […] The patient had an untoward clinical course despite treatment with hydroxychloroquine, azithromycin, and corticosteroids, dying on the third day of hospitalization. | 2020-08-18 |
| 32804922 | To characterize the clinical manifestations and course of the first cases of contagion by SARS-CoV-2 in doctors of Peru. […] We present a series of six cases of doctors infected by SARS-CoV-2, with confirmed positivity for COVID-19, showing the daily evolution from the diagnosis of the disease, its main signs and symptoms, evolution, and until the outcome in each case. […] The most frequent symptoms were axillary temperature above 38°C, malaise, dry cough, and odynophagia (the latter in three of the cases). […] The symptoms that persisted the most were dry cough (present during ten days in four doctors). […] Despite a small number of cases, it is the first report detailing the evolution of symptoms day by day, which can help for occupational health and even for case surveillance and monitoring. | 2020-08-18 |
| 32804923 | The outcomes considered will be clinical effectiveness depending on the specific condition, functionality, quality of life, satisfaction, adherence, and safety. | 2020-08-18 |
| 32805004 | Many believe Artificial Intelligence (AI) is a solution to guide clinical decision making for this novel disease, resulting in the rapid dissemination of under-developed and potentially biased models, which may exacerbate the disparities gap. | 2020-08-18 |
| 32805023 | Clinical data supports that overactivation of neutrophil for severe patients can be one major factor for the similar clinical symptoms observed in SARS-CoV-2 infection compared to infections of the other two severe coronavirus (SARS-CoV, and MERS-CoV). | 2020-08-18 |
| 32805036 | Though organizational clinical data are abundant, these are largely inaccessible to outside researchers. […] The Clinical and Translational Science Award (CTSA) Program and scientific community created N3C to overcome technical, regulatory, policy, and governance barriers to sharing and harmonizing individual-level clinical data. […] The N3C has demonstrated that a multi-site collaborative learning health network can overcome barriers to rapidly build a scalable infrastructure incorporating multi-organizational clinical data for COVID-19 analytics. […] Though medical records are abundant, they are largely inaccessible to outside researchers. […] Here, we introduce the National COVID Cohort Collaborative (N3C), an open science community focused on analyzing patient-level data from many clinical centers to reveal patterns in COVID-19 patients. […] To create N3C, the community had to overcome technical, regulatory, policy, and governance barriers to sharing patient-level clinical data. | 2020-08-18 |
| 32805057 | Mechanistic and clinical studies addressing the captioned subject are urgently needed, especially in relation to COVID-19. | 2020-08-18 |
| 32805123 | The coronavirus disease 2019 (COVID-19) pandemic has expanded the utilization of telemedicine in clinical practice to minimize potential risks to both patients and providers. | 2020-08-18 |
| 32805256 | Our proposed mechanisms could pave the way for further in vitro studies and subsequent clinical trials. | 2020-08-18 |
| 32805298 | The American Thoracic Society and Infectious Diseases Society of America have updated CAP guidelines to help streamline disease management. | 2020-08-18 |
| 32805345 | Admission glucose was correlated with most clinical severity indexes and its association with adverse outcome was mostly mediated by a worse respiratory function. | 2020-08-18 |
| 32805546 | In this article, we review the role of the ECG in the identification of cardiac involvement in COVID-19, highlighting relevant clinical implications. | 2020-08-18 |
| 32805629 | We report a miscarriage rate of 14.4 % (n = 15) and documented 10 patients (11.3 %) who had symptoms related to COVID-19. […] No severe symptoms and no hospitalization in intensive care unit were identified. […] None of the patients who had COVID-related symptoms presented with severe clinical manifestations. | 2020-08-18 |
| 32805631 | Between the number of reported symptoms and antibody responses in COVID-19 patients no correlation was found and no new cases of seroconversion were identified in asymptomatic coworkers with negative PCR during the outbreak. | 2020-08-18 |
| 32805640 | Phase 1 studies are among the most complicated clinical trials and require thorough patient selection, as well as intensive patient monitoring. […] We notably present the risks and challenges raised by COVID-19-infected phase 1 patients, in terms of safety, toxicity causality assessment, drug efficacy evaluation and clinical research priorities. | 2020-08-18 |
| 32805702 | The main outcome was VTE incidence, and measures included patient characteristics, anticoagulation, and clinical outcomes with assessment for associations. | 2020-08-18 |
| 32805726 | Among the 34 patients with acute abdomen, a total of six cases were found with COVID-19 pneumonia (clinical classification for COVID-19 pneumonia: all were the common type). […] Compared with acute abdomen patients without COVID-19, patients with COVID-19 pneumonia had a longer hospital stay, but there were no significant differences in postsurgical complications (P = 0.58) or clinical outcomes (P = 0.56). | 2020-08-18 |
| 32805728 | The clinical diagnosis of patients with COVID-19 has risen sharply, especially in Western countries. | 2020-08-18 |
| 32805730 | We aim to describe the clinical characteristics and risk factors of severe patients with COVID-19 in Guangzhou. | 2020-08-18 |
| 32805781 | We aim to describe the basic demographics, clinical course and outcomes of critically ill patients with Covid-19 admitted to Avera McKennan Hospital and University Health Center Intensive Care Unit (ICU) between March 20 and May 4, 2020. […] Demographic data, admitting symptoms, laboratory values, co-morbidities, treatments and clinical outcomes were collected. […] Most common presenting symptoms were dyspnea (92 percent), cough (70 percent) and fever (68 percent). | 2020-08-18 |
| 32806657 | From a clinical point of view, COVID-19 would be defined as “COVID Planet” because it presents as a multifaceted disease, due to the large number of organs and tissues infected by the virus. […] This review summarizes the current knowledge on the main biological and clinical features of the SARS-CoV-2 pandemic, also focusing on the principal measures taken in some Italian regions to face the emergency and on the most important treatments used to manage the COVID-19 pandemic. | 2020-08-19 |
| 32806699 | Our study showed that healthcare workers who are exposed to SARS-CoV-2-infected patients at emergency wards, infectious wards, and intensive care units are at a much higher risk of showing symptoms of anxiety, depression, and sleep disorders than healthcare workers working in other wards. | 2020-08-19 |
| 32806708 | Specifically, we have focused on various aspects, including host species, organotropism, transmission, clinical disease, pathogenesis, control and therapy, MHV as a model for SARS-CoV and SARS-CoV-2 as well as mouse models for infection with SARS-CoV and SARS-CoV-2. […] Translational approaches, such as humanized mouse models are pivotal in studying the clinical course and pathology observed in COVID-19 patients. | 2020-08-19 |
| 32806769 | Before an appointment, 1182 (96%) respondents always/often inquired per phone information if a patient experienced symptoms of COVID-19, and 1104 (89%) asked about a history of travel to affected areas. | 2020-08-19 |
| 32806993 | We want to share our logistical and clinical integrated pathway that is aimed to screen and refer each patient to the most appropriate level of care in order to optimize resources and avoid overwhelming the available clinics. | 2020-08-19 |
| 32806998 | Thus, we investigated the clinical characteristics of patients with COVID-19 and further determined the risk factors for cardiac involvement in them. […] Epidemiologic and demographic characteristics, clinical features, routine laboratory tests (including cardiac injury biomarkers), echocardiography, electrocardiography, chest imaging findings, management methods, and clinical outcomes were collected. | 2020-08-19 |
| 32807018 | The first case of a novel coronavirus (COVID-19) infection was detected in Wuhan, fever and respiratory symptoms have been frequently reported in patients infected with this virus. […] It was aimed to compare the symptoms of patients with COVID-19 positivity and patients without COVID-19 positivity hospitalized with suspicion of COVID-19. […] Samples were obtained from the patients and PCR tests were performed; the patients were grouped as COVID-19 positive and COVID-19 negative; these two groups were questioned for 15 symptoms and the results were compared. […] The most common symptoms in the COVID-19 positive group were: cough (56.6%), weakness (56.6%), taste disorder (35.7%), myalgia (34.3%), and fever (33.6%); and in the COVID-19 negative group: cough (63%), weakness (45.5%), dyspnea (29.9%), headache (27.3%) and fever (24.7%). | 2020-08-19 |
| 32807209 | Other ongoing trials are exploring short courses of azithromycin either in early disease, within the first 7 days of symptoms, when azithromycin’s antiviral properties may be important, or late in disease when anti-bacterial properties may reduce the risk of secondary bacterial infection. […] ATOMIC2 is a phase II/III, multi-centre, prospective, open-label, two-arm randomised superiority clinical trial of azithromycin versus standard care for adults presenting to hospital with COVID-19 symptoms who are not admitted at initial presentation. […] We will enrol adults, ≥ 18 years of age assessed in acute hospitals in the UK with clinical diagnosis of COVID-19 infection where management on an ambulatory care pathway is deemed appropriate. […] This trial will determine the clinical utility of azithromycin in patients with moderately severe, clinically diagnosed COVID-19 and could be rapidly applicable worldwide. | 2020-08-19 |
| 32807241 | Active bleeding or on-going clinical condition deemed at high risk of bleeding contraindicating anticoagulant treatment 7. […] Clinical decision to withhold life-sustaining treatment or “too sick to benefit” 11. […] After ICU discharge anticoagulant therapy may be interrupted or switched to prophylaxis with LMWH in the destination ward up to clinical judgement of the attending physician. […] After ICU discharge it may be continued or interrupted in the destination ward up to clinical judgement of the attending physician. | 2020-08-19 |
| 32807412 | Ultimately, this will help guide clinical-based policies surrounding COVID-19 and other similar global pandemics to ensure that management of cerebrovascular comorbidity is appropriately prioritized during the global crisis. | 2020-08-19 |
| 32807416 | She was treated outside the COVID-19-dedicated track of the hospital because she had no concomitant signs or symptoms suggestive of SARS-CoV-2 infection nor recent contact with other infected individuals. | 2020-08-19 |
| 32807425 | This guidance is to be adapted to the available resources of a local institution and does not replace clinical judgment when faced with an individual patient. | 2020-08-19 |
| 32807426 | Reversible cerebral vasoconstriction syndrome (RCVS) is a well-described clinical syndrome leading to vasoconstriction in the intracra- nial vessels, and has been associated with convexity subarachnoid hemorrhage and oc- casionally cervical artery dissection. | 2020-08-19 |
| 32807431 | Overall, his clinical course improved, and he was discharged with minimal neurological deficits. | 2020-08-19 |
| 32807464 | Acute stroke patients continue to present to the emergency department and they may not have the usual symptoms of COVID-19 infection. | 2020-08-19 |
| 32807490 | The highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected every aspect of medical practice and has all but ceased clinical, translational and basic science research. | 2020-08-19 |
| 32807512 | Gastrointestinal symptoms include diarrhea, epigastric pain, nausea, and vomiting. […] Diarrhea is the most common GI manifestation of SARS-CoV-2 and can present without or without respiratory symptoms. […] Patients with GI symptoms have been associated with longer duration of illness and may be associated with more severe illness. […] Inflammatory response and cytokine release likely contributes to symptoms. | 2020-08-19 |
| 32807535 | These outbreaks share many similarities, including clinical presentation, transmission, and management. […] Although respiratory manifestations are responsible for most of the morbidity and mortality in these conditions, extra-pulmonary manifestations such as gastrointestinal symptoms are also increasingly recognized as important symptoms. […] Important gastrointestinal symptoms include nausea, vomiting, anorexia, diarrhea, and abdominal pain. […] Early identification of GI symptoms is crucial as some patients can present only with GI manifestations in the absence of pulmonary symptoms. […] This has been reported even after the resolution of respiratory symptoms and can extend up to many days from the onset of symptoms. […] Though GI symptoms are frequently observed, understanding the pathogenesis of these symptoms is crucial, as it can not only of public health importance but could also identify infected patients early in the spread. […] Understanding the different GI and hepatic manifestations with underlying mechanisms of symptoms can assist in the therapeutic management of these patients. | 2020-08-19 |
| 32807570 | The increasing frequency of confirmed COVID-19 cases is striking, and new sensitive diagnostic tools are needed to guide clinical practice. | 2020-08-19 |
| 32807723 | In the absence of direct evidence with patients infected with COVID-19, studies in comparable populations are currently the best resource to guide probiotics interventions in conjunction with clinical expertise and multidisciplinary health care planning. | 2020-08-19 |
| 32807764 | COVID-19 can cause a significant inflammatory response leading to coagulopathy and this hypercoagulable state has been associated with worse clinical outcomes in these patients. | 2020-08-19 |
| 32807895 | Despite several ongoing clinical studies, there are currently no approved vaccines or drugs that specifically target SARS-CoV-2. | 2020-08-19 |
| 32807934 | Some signature traits identify links with other settings of immunoprotection and immunopathology; others, including basophil and plasmacytoid dendritic cell depletion, correlate strongly with disease severity; while a third set of traits, including a triad of IP-10, interleukin-10 and interleukin-6, anticipate subsequent clinical progression. | 2020-08-19 |
| 32808089 | The Italian Society of Radiotherapy and Clinical Oncology (AIRO) identified the need of practice recommendations on logistic issues, treatment delivery and healthcare personnel’s protection in a time of limited resources. | 2020-08-19 |
| 32808111 | A total of 145 serum samples from 145 patients with clinical suspicion of COVID-19 were collected: all of the samples were tested with Sienna®, 117 with Wondfo® and 89 with Prometheus®. | 2020-08-19 |
| 32808174 | Clinical presentation and diagnostic work-up of the patients. […] Full-dose anticoagulation and clinical-radiological monitoring might reduce their neurological consequences. | 2020-08-19 |
| 32808273 | Due to the adoption of a combined clinical-imaging-laboratory approach, WMD is becoming better recognised, in addition to the rapidly evolving field of genomics in this area. […] While paediatric WMDs have a well-defined and literature-based clinical-laboratory approach to diagnosis, adult-onset WMDs remain an important, pathologically diverse, radiographic phenotype, with different and distinct neuropathologies among the various subtypes of WMD. […] We propose a combined clinical-imaging-laboratory approach to WMD and continued exploration of acquired and genetic factors. | 2020-08-19 |
| 32808446 | Standard and clinical chemistry diagnostics were developed in response to the outbreak. […] Most of the therapeutic methods used during the outbreak relied on treating symptoms of the underlying illness, such as lower respiratory infections and systemic infection, rather than effectively suppressing or curtailing replication of the virus. | 2020-08-19 |
| 32808462 | These cells, already used in preclinical models of ARDS, sepsis, and septic shock and also in few clinical trials appear well-tolerated, promising, but many questions remain unanswered. | 2020-08-19 |
| 32808513 | There is limited information describing the presenting characteristics and dynamic clinical changes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosed in the early phase of illness. […] Among the mild group of 136 patients, 11.7% of patients experienced clinical aggravation during hospitalization, but there was no initial clinical parameter on admission predicting their aggravation. […] Clinical aggravation among asymptomatic or mild patients could not be predicted initially but was heralded by fever and several laboratory markers during the clinical course. | 2020-08-19 |
| 32808545 | Consecutive patients who underwent chest CT because of clinical suspicion of COVID-19 were included. | 2020-08-19 |
| 32808695 | Bacterial coinfection was determined by the presence of characteristic clinical features and positive culture results. | 2020-08-19 |
| 32808712 | Being a pandemic and having a high global case fatality rate directed us to assess the evidence strength of hydroxychloroquine efficacy in treating coronavirus disease-2019 (COVID-19) arising from clinical trials and to update the practice with the most reliable clinical evidence. […] Of 432 studies found, only six studies fulfilled the inclusion criteria, which includes: clinical trials, age more than 12 years with nonsevere COVID-19, polymerase chain reaction-confirmed COVID-19, hydroxychloroquine is the intervention beyond the usual care. […] The primary outcomes are clinical and radiological COVID-19 progression, severe acute respiratory syndrome coronavirus-2 clearance in the pharyngeal swab, and mortality. […] On the other hand, hydroxychloroquine did not prevent clinical COVID-19 progression, reduce 5-day mortality, or enhance viral clearance on days 5, 6, and 7. […] Failure of hydroxychloroquine to show viral clearance or clinical benefits with additional adverse effects outweigh its protective effect from radiological progression in nonsevere COVID-19 patients. | 2020-08-19 |
| 32808759 | An exploratory clinical study with this approach was examined in Wuhan, China, during March 2020. | 2020-08-19 |
| 32808850 | COVID-19 shares many clinical characteristics with other respiratory illnesses.Accurate and early detection of the infection is pivotal to controlling the outbreak, as this enables case identification, isolation, and contact tracing. | 2020-08-19 |
| 32808872 | Nasal symptoms can identify patients more likely to produce droplets after sneeze/cough. | 2020-08-19 |
| 32808877 | Confirmatory factor analysis demonstrated that dysfunctional coronavirus anxiety symptoms cohered into a reliable, single factor structure of coronaphobia. […] The findings collectively support the coronaphobia construct with healthcare professionals, and the finding that over one third of the participants in the study scored in the clinical range on this measure points to the critical importance of assessing and alleviating this form of distress in this vulnerable but indispensable workforce. | 2020-08-19 |
| 32808941 | We aimed to quantify the extent of the hypermetabolic state and report the clinical effect of the use of hypothermia to decrease the metabolic demand in these patients. | 2020-08-19 |
| 32808970 | The association between clinical characteristics of the virus and neutralizing antibodies (NAbs) against this virus have not been well studied. […] To examine the association between clinical characteristics and levels of NAbs in patients who recovered from COVID-19. […] In this cohort study, a total of 175 patients with mild symptoms of COVID-19 who were hospitalized from January 24 to February 26, 2020, were followed up until March 16, 2020, at Shanghai Public Health Clinical Center, Shanghai, China. […] Secondary outcomes included spike-binding antibodies, cross-reactivity against SARS-associated CoV, kinetics of NAb development, and clinical information, including age, sex, disease duration, length of stay, lymphocyte counts, and blood C-reactive protein level. […] Further research is needed to understand the clinical implications of differing NAb titers for protection against future infection. | 2020-08-19 |
| 32808976 | Kinetics of IgA/IgM/IgG seroconversion to viral N and S protein epitopes were studied from 0 to 54 days after onset of symptoms. […] Elecsys Anti-SARS-CoV-2 assay and EUROIMMUN Anti-SARS-CoV-2 combined IgG/IgA showed acceptable sensitivity (>95%) vs the consensus result of all assays from 10 days post onset of symptoms. […] Wantai SARS-COV-2 Ab ELISA and Elecsys Anti-SARS-CoV-2 assays are suitable for sensitive and specific detection of SARS-CoV-2 antibodies from 10 days after onset of symptoms. | 2020-08-19 |
| 32808988 | The panel devised a framework for considering the use of immunomodulatory therapy based on an assessment of clinical disease severity and degree of multi-organ involvement combined with evidence of hyperinflammation. […] When available, the panel strongly favors immunomodulatory agent use within the context of clinical trials. […] The framework presented herein offers an approach to decision-making regarding immunomodulatory therapy for severe or critical pediatric COVID-19 and is informed by currently available data, while awaiting results of placebo-controlled randomized clinical trials. | 2020-08-19 |
| 32809033 | To evaluate the association of race, adjusting for sociodemographic and clinical factors, on all-cause, in-hospital mortality for patients with COVID-19. | 2020-08-19 |
| 32809036 | In this respect, its validity has to be proved in comparison to clinical-radiological experiences. […] CT in clinical routine has a high sensitivity for pneumonia. | 2020-08-19 |
| 32809050 | The need for a personalized approach based on the current clinical situation was emphasized by many respondents. […] The currently low prevalence of COVID-19 in Germany limits the general clinical experience. | 2020-08-19 |
| 32809060 | We undertook an evaluation of differences in COVID-19 symptom occurrence rates, COVID-19 testing rates, clinical care activities, knowledge of COVID-19, and use of mitigation procedures between patients who were and were not receiving active cancer treatment. […] Patients who were not on active treatment reported a higher mean number of COVID-19 symptoms (3.1 (± 4.2) versus 1.9 (± 2.6)), and patients who reported a higher number of COVID-19 symptoms were more likely to be tested. […] The high level of COVID-19 symptoms and the significant overlap of COVID-19 and cancer-related symptoms pose challenges for clinicians who are assessing and triaging oncology patients for COVID-19 testing. […] For patients on active treatment, clinicians face challenges with how to assess and manage symptoms that, prior to COVID-19, would be ascribed to acute toxicities associated with cancer treatments or persistent symptoms in cancer survivors. | 2020-08-19 |
| 32809207 | Aim of the study is to evaluate the incidence of DVT in COVID-19 patients and its correlation with the severity of the disease and with clinical and laboratory findings. 234 symptomatic patients with COVID-19, diagnosed according to the World Health Organization guidelines, were included in the study. […] DUS findings, clinical, laboratory’s and therapeutic variables were investigated by contingency tables, Pearson chi square test and by Student t test and Fisher’s exact test. | 2020-08-19 |
| 32809210 | The systematic review highlighted the lacuna and methodologic deficiency in early clinical evidence and included an update on different therapeutic management guidelines. […] Further clinical evidence from the ongoing trials may lead to evolution of treatment guidelines with the addition of more therapeutic options. | 2020-08-19 |
| 32809211 | At present we are passing through a phase of slow and painful understanding of the origin, epidemiological profile, clinical spectrum, and risk profile of the virus. | 2020-08-19 |
| 32809292 | Descriptions of the potential neurological symptoms in this disease state exist, but minimal research has been conducted on the prevalence of delirium. […] This case report describes a patient with no past psychiatric history who developed psychotic symptoms in the context of acute COVID-19 delirium. […] Clinicians should consider COVID-19 in their differential diagnosis with any patient who presents with psychotic symptoms, even in the absence of the typical COVID-19 symptoms of cough or fever. | 2020-08-19 |
| 32809853 | Women, the unemployed, those with lower education, living in rural areas, and with flu-like symptoms or chronic disorders were risk factors. | 2020-08-19 |
| 32809916 | Introduction: Telemedicine and telepsychiatry, in particular, are rapidly becoming important delivery approaches to providing clinical care and information to patients in cases wherein the medical resources and the patients are very hard to be brought together with respect to rules of behavior in case of epidemics. […] The reliance on technology to bridge the obstacles between the patients (consumers) and medical resources (providers) can create problems that impact service delivery and outcomes, but in cases such as this (COVID-19 pandemics), this is virtually the only tool for providing clinical care and information to patients. | 2020-08-19 |
| 32809918 | Damage to T lymphocytes along with the cytokine storm are important factors that lead to exacerbation of clinical cases. | 2020-08-19 |
| 32809920 | Team role deployment and bedside clinical care centering around TCC as critical care capacity expand beyond 275 beds. | 2020-08-19 |
| 32809968 | Objectives We describe a standardized, scalable outpatient surveillance model for pregnant women with COVID-19 with several objectives: (1) to identify and track known, presumed, and suspected COVID-positive pregnant patients both during their acute illness and after recovery, (2) to regularly assess patient symptoms and escalate care for those with worsening disease while reducing unnecessary hospital exposure for others, (3) to educate affected patients on warning symptoms, hygiene, and quarantine recommendations, and (4) to cohort patient care, isolating stable infected patients at home and later within the same physical clinic area upon their return to prenatal care. | 2020-08-19 |
| 32809969 | Baricitinib prevented the progression towards a severe/extreme form of the viral disease by modulating the patients’ immune landscape and these changes were associated with a safer and favorable clinical outcome of patients with COVID-19 pneumonia. | 2020-08-19 |
| 32810081 | Many patients develop severe symptoms requiring endotracheal intubation and a prolonged stay in the Intensive Care Unit (ICU). | 2020-08-19 |
| 32810285 | Fifty studies involving 15 in vitro and 35 clinical studies including 9170 nCOV-2019 patients were included. […] Lopinavir-ritonavir was significantly associated with shorter mean time to clinical recovery (SMD -0.32; 95% CI -0.57 to -0.06), remdesivir was significantly associated with better overall clinical recovery (RR 1.17; 95% CI 1.07 to 1.29), and tocilizumab was associated with less all-cause mortality (RR 0.38; 95% CI 0.16 to 0.93). […] Hydroxychloroquine was associated with longer time to clinical recovery and less overall clinical recovery. […] Results from upcoming large clinical trials may further clarify role of these drugs. | 2020-08-19 |
| 32810408 | Significant progress is being made in understanding the pathogenesis and clinical consequences of COVID-19. […] Based on the presence of atypical symptoms, the significant numbers of asymptomatic individuals who are COVID-19 positive, and the high susceptibility to viral diseases observed in pregnant women, recommendations have been put forth to limit the exposure of COVID-19-positive or even suspected cases to pregnant HCPs, and these are likely to evolve as new information becomes available. […] Dental and health care professionals can use the information in this review to improve their awareness of COVID-19 risks, signs, and symptoms and the associated effects on the health of pregnant health care professionals and their unborn/newborn children. | 2020-08-19 |
| 32810418 | ; (3) The Pennsylvania experience - using observations from the population of one major delivery ecosystem (Jefferson Health), a major accountable care organization (Delaware Valley ACO), and statewide data from Pennsylvania; and (4) What should be the priorities and focus of the delivery system of the future given the dramatic financial and clinical disruption of COVID-19? | 2020-08-19 |
| 32810517 | There is inconclusive and controversial evidence of the association between allergic diseases and the risk of adverse clinical outcomes of coronavirus disease 2019 (COVID-19). […] We sought to determine the association of allergic disorders with the likelihood of a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test result and with clinical outcomes of COVID-19 (admission to intensive care unit, administration of invasive ventilation, and death). […] The association of SARS-CoV-2 test positivity and allergic diseases in the entire cohort (n = 219,959) and the difference in clinical outcomes of COVID-19 were evaluated in patients with allergic diseases and SARS-CoV-2 positivity (n = 7,340). […] After propensity score matching, we found that asthma and allergic rhinitis were associated with worse clinical outcomes of COVID-19 in patients with SARS-CoV-2 test positivity. […] Patients with nonallergic asthma had a greater risk of SARS-CoV-2 test positivity and worse clinical outcomes of COVID-19 than patients with allergic asthma. […] In a Korean nationwide cohort, allergic rhinitis and asthma, especially nonallergic asthma, confers a greater risk of susceptibility to SARS-CoV-2 infection and severe clinical outcomes of COVID-19. | 2020-08-19 |
| 32810602 | In this regard, identifying HLA-SARS-CoV-2 peptides binding differences between individuals would help to clarify the heterogeneity of clinical responses to the disease and will also be useful to guide a personalized treatment according to its particular risk. | 2020-08-19 |
| 32810610 | To describe clinical characteristics, management and outcome of individuals with coronavirus disease 2019 (COVID-19); and to evaluate risk factors for all-cause in-hospital mortality. […] Common symptoms at the time of COVID-19 diagnosis included fever (285/317; 89.9%), shortness of breath (167/317; 52.7%) and dry cough (156/317; 49.2%). | 2020-08-19 |
| 32810701 | To evaluate the diagnostic and prognostic performance of CT in patients referred for COVID19 suspicion to a French university hospital, depending on symptoms and date of onset. […] Sensitivity, specificity, negative and positive predictive values of first and expert readings were calculated together with inter reader agreement, with results of RT-PCR as standard of reference and according to symptoms and onset date. […] Considering the 123 patients with symptoms for more than 5 days, the corresponding figures were 90 %, 78 %, 80 % and 89 % for initial reading and 93 %, 88 %, 86 % and 94 % for the expert. […] CT sensitivity increased after 5 days of symptoms. | 2020-08-19 |
| 32810840 | For this analysis, we have included 110 sera from patients presenting with COVID-19 symptoms or blood donors without symptoms collected at the Austrian Red Cross, Blood Transfusion Service for Upper Austria, Linz. | 2020-08-19 |
| 32810841 | Telemedicine (ie, video visits) is a potentially disruptive innovation; however, little is known about patient satisfaction with this emerging alternative to the traditional clinical encounter. | 2020-08-19 |
| 32810855 | This prospective study aimed to assess the impact of the COVID-19 outbreak on mental health and to investigate the ability of pre-outbreak SOC levels to predict changes in psychopathological symptoms. […] This study assessed psychopathological symptoms and SOC before and after the COVID-19 outbreak as well as post-outbreak COVID-19-related traumatic distress in a German-speaking sample (n =1,591). […] Bivariate latent change score (BLCS) modeling was used to analyze pre- to post-outbreak changes in psychopathological symptoms and the ability of SOC to predict symptom changes. […] Overall, there was no change in psychopathological symptoms. […] However, on an individual-respondent level, 10% experienced a clinically significant increase in psychopathological symptoms and 15% met cut-off criteria for COVID-19-related traumatic distress. […] Using BLCS modeling, we identified a high-stress group experiencing an increase in psychopathological symptoms and a decrease in SOC and a low-stress group showing the reversed pattern. […] Changes in SOC and psychopathological symptoms were predicted by pre-outbreak SOC and psychopathological symptom levels. […] Although mental health was stable in most respondents, a small group of respondents characterized by low levels of SOC experienced increased psychopathological symptoms from pre- to post-outbreak. | 2020-08-19 |
| 32810867 | A prominent clinical symptom of 2019-novel coronavirus (nCoV) infection is hyposmia/anosmia (decrease or loss of sense of smell), along with general symptoms such as fatigue, shortness of breath, fever and cough. […] The identity of the cell lineages that underpin the infection-associated loss of olfaction could be critical for the clinical management of 2019-nCoV-infected individuals. | 2020-08-19 |
| 32810894 | We report the clinical and biochemical features of liver involvement, and the comorbidities that present with hepatitis, in a substantial cohort of patients. | 2020-08-19 |
| 32811323 | Especially the social isolation, the higher amount of care, the uncertainty of the situation and the increase in psychological symptoms are described as being stressful. | 2020-08-20 |
| 32811328 | The COVID-19 pandemic poses additional challenges to the disease management of people with COPD. | 2020-08-20 |
| 32811406 | We illustrate recent publications on SARS-CoV-2, concerning its molecular, epidemiological, and clinical characteristics, and focus on innovative diagnostics technologies in the production pipeline. […] The study explores the race toward vaccine development and highlights some significant trials and candidates in various clinical phases. […] This research addresses critical knowledge gaps by identifying repurposed drugs currently under clinical trials. | 2020-08-20 |
| 32811531 | The incidence of progression from severe to critical illness, 28-day mortality, clinical symptom improvement, time to clinical symptom improvement, hematologic indicators including C-reactive protein, lymphocyte number, and interleukin 6, and imaging changes were observed and compared between the two groups. […] In the hUC-MSC treatment group, the time to clinical improvement was shorter than that in the control group. […] Clinical symptoms of weakness and fatigue, shortness of breath, and low oxygen saturation obviously improved beginning on the third day of stem cell infusion and reached a significant difference on day 7. […] Chinese Clinical Trial Registration; ChiCTR2000031494; Registered on 2 April 2020; http:// www.medresman.org. | 2020-08-20 |
| 32811575 | While at a relatively early stage of clinical development, and notwithstanding the immense challenges of COVID-19, psilocybin therapy has the potential to play an important therapeutic role for various psychiatric disorders in post-COVID-19 clinical psychiatry. | 2020-08-20 |
| 32811585 | The COVID-19 pandemic has had a major impact on clinical practice. […] The Canadian Society of Clinical Neurophysiologists, the Canadian Association of Electroneurophysiology Technologists, the Association of Electromyography Technologists of Canada, the Board of Registration of Electromyography Technologists of Canada, and the Canadian Board of Registration of Electroencephalograph Technologists have combined to review current published literature about safe practices for neurophysiology laboratories. | 2020-08-20 |
| 32811605 | None of COVID-19 IgG reactive cases exhibited symptoms and most of them performed duties at high risk areas with only masks provided as personal protective equipment. […] COVID-19 IgG antibody reactive cases may not show any symptoms. | 2020-08-20 |
| 32811627 | Clinical trials represent an essential component of improving treatment for substance use disorders (SUD). […] The SARS coronavirus-2 pandemic disrupted our ongoing clinical trial of smoking cessation and forced us to rapidly implement changes to assure participants access to ongoing counseling and monitoring via telephone calls and/or video chat sessions. […] Our experiences suggest that this pandemic will lead to changes for both future clinical trial participants and project staff. | 2020-08-20 |
| 32811667 | We describe our strategy for the management of cancer patients based on the experience of the medical staff of the Regional Clinical Oncology Center of the Republic of Bashkortostan. | 2020-08-20 |
| 32811670 | We systematically searched the PubMed, Web of Science, MedRxiv and COVID-19 academic research communication platform for studies reporting clinical severity and/or overall mortality data on DM in patients with COVID-19 published up to July 10, 2020. | 2020-08-20 |
| 32811800 | A detailed retrospective investigation in the form of one-to-one interview was carried out with 16 recovered individuals to understand the transmission dynamics and clinical characteristics. […] Most of the cases were asymptomatic except two individuals, who developed mild symptoms. | 2020-08-20 |
| 32811801 | In this study we describe the epidemiological data, comorbidities, clinical symptoms, severity of illness and early outcome of patients with coronavirus disease 2019 (COVID-19) from a tertiary care teaching hospital in New Delhi, India. […] Demographics, clinical data and 24 h outcome were assessed. […] Fever (68.1%), cough (59.6%) and shortness of breath (71.9%) were the most common presenting symptoms. | 2020-08-20 |
| 32811804 | Because clinical diagnosis of ARDS includes several diseases, understanding the characteristics of COVID-19-related ARDS is necessary for precise treatment. | 2020-08-20 |
| 32811894 | To overcome this barrier, a biochemical understanding of the clinical effects of LCTE is needed. […] Our results indicate that LCTE contains compounds with the potential to directly inhibit SARS-CoV-2 and inflammation, and that the compound targets proteins highly related to COVID-19’s main symptoms. […] Our work provides a biochemical basis for using LCTE to treat COVID-19 and its main symptoms. | 2020-08-20 |
| 32812012 | Recent reports highlight a new clinical syndrome in children related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1-multisystem inflammatory syndrome in children (MIS-C)-which comprises multiorgan dysfunction and systemic inflammation2-13. […] We performed peripheral leukocyte phenotyping in 25 children with MIS-C, in the acute (n = 23; worst illness within 72 h of admission), resolution (n = 14; clinical improvement) and convalescent (n = 10; first outpatient visit) phases of the illness and used samples from seven age-matched healthy controls for comparisons. | 2020-08-20 |
| 32812014 | In contrast to an acute cold, it appears from several questionnaire-based studies that in the context of COVID-19 infection, anosmia is the main rhinological symptom and is usually not associated with other rhinological symptoms such as rhinorrhoea or nasal obstruction. | 2020-08-20 |
| 32812035 | The coronavirus 2019 (COVID-19) pandemic is a clinical situation that could be used as prototype for implementation of new systems of care. | 2020-08-20 |
| 32812039 | The aim of this trial was to assess if the addition of sofosbuvir and daclatasvir improved clinical outcomes in patients with moderate or severe COVID-19. […] This was an open-label, multicentre, randomized controlled clinical trial in adults with moderate or severe COVID-19 admitted to four university hospitals in Iran. […] The primary endpoint was clinical recovery within 14 days of treatment. […] Clinical recovery within 14 days was achieved by 29/33 (88%) in the treatment arm and 22/33 (67%) in the control arm (P = 0.076). | 2020-08-20 |
| 32812055 | Twenty specimens were from patients not considered COVID-positive (due to PCR swab negativity or not tested at all) with cutaneous lesions either showing viral infection symptoms (fever, cough, ageusia and severe immunocompromised condition due to HIV infection and malignancies), or presented a high risk of being infected (such as cohabitation with COVID-19 positive parents and siblings with simultaneous chilblains). | 2020-08-20 |
| 32812187 | In fact, this systematic review-meta-analysis was directly pertained to estimation at the efficient value of some clinical managements to confront the COVID-19 infection. […] The outcomes of this study were the frequency of negative conversion cases, clinical improvements, mechanical ventilation demand, intensive care unit (ICU) entry, and mortality. […] Anti-COVID-19 interventions could significantly increase clinical improvement (RR 1.17, 95% CI 1.08-1.27; I2 = 49.8%) and reduce the mortality rate (RR 0.58, 95% CI 0.35-0.95; I2 = 74.8%). […] Although in terms of negative conversion, ICU entry, and mechanical ventilation demand, clinical intervention had no beneficial effect. […] The clinical effect of immunomodulatory agents (especially tocilizumab and anakinra) was noticeable compared to other medications with RR of 0.22 (95% CI 0.09-0.53; I2 = 40.9%) for mortality and 1.25 (95% CI 1.07-1.46; I2 = 45.4%) for clinical improvement. […] Moreover, Antivirals (RR 1.13, 95% CI 1.01-1.26; I2 = 47.0%) and convalescent plasma therapy (RR 1.41, 95% CI 1.01-1.98; I2 = 66.6%) had significant beneficial effects on clinical improvement. […] Based on our findings, all the included interventions significantly declined the mortality and enhanced clinical improvements with no effect on negative conversion and mechanical ventilation demand. | 2020-08-20 |
| 32812199 | We performed a systematic complete doppler ultrasound (CDU) at a median 4 days after admission in 42 consecutive COVID-19 patients hospitalized in general wards of our university hospital, irrespective of D-Dimer level, and retrospectively collected clinical, biological and outcome data from electronic charts. | 2020-08-20 |
| 32812204 | The most contributory variables to the models were APACHE II score, white blood cell count, time from symptoms to admission, oxygen saturation and blood lymphocytes count. | 2020-08-20 |
| 32812356 | As epidemiology and clinical practice will reveal the actual needs of young people, the hope is that we will find the focus and determination to build new solutions to promote young people’s mental health. | 2020-08-20 |
| 32812477 | The diminished ovarian reserve and previous ART failure significantly predicted the presence of clinical state-anxiety. | 2020-08-20 |
| 32812534 | Ongoing transmission is especially difficult to prevent when the pathogen can be transmitted during the incubation period before the patient experiences symptoms. […] In March, Claire Hopkins and colleagues warned the rhinologic community and later health authorities about the significant increase in anosmia (and dysgeusia) related to (often further) asymptomatic COVID-19 and pointed to the possibility of recognizing COVID-19 patients by unexplained anosmia without other symptoms. | 2020-08-20 |
| 32812716 | Pre-clinical medical studies were concomitantly switched to electronic distance learning. […] To explore potential implications of COVID-19 on future pre-clinical medical studies. […] We examined responses of pre-clinical medical students to the remote electronic learning in terms of quality of and satisfaction with teaching and technical support, attendance to classes, and the desire to continue electronic learning in the post-epidemic era. […] The high satisfaction and the positive experience with the electronic distance learning imposed by the COVID-19 epidemic implied a successful transition and might induce future changes in pre-clinical medical studies. | 2020-08-20 |
| 32812717 | In this cross-sectional study, we obtained clinical and laboratory data regarding 39 hospitalized patients with confirmed COVID-19 from two hospitals in Israel. | 2020-08-20 |
| 32813051 | Data were obtained during a randomized clinical trial on rehabilitation taking place at 11 centers in North America and Europe. […] During study closure, a COVID Impact Survey was administered via telephone or email to all participants, along with measures of depressive symptoms, anxiety symptoms, quality of life, and MS symptomatology that were previously administered pre-pandemic. 4% of respondents reported COVID-19 infection. […] No significant relationships were noted between disease duration, processing speed ability or EDSS, and changes in symptoms of depression or anxiety. […] Overall, little change was noted in symptoms of depression or anxiety or overall quality of life. | 2020-08-20 |
| 32813065 | Other symptoms include headache, sore throat, rhinorrhea, and gastrointestinal disorders. | 2020-08-20 |
| 32813069 | We also present laboratory and clinical data. […] We also report the clinical course of these patients. | 2020-08-20 |
| 32813110 | Therefore, utilizing remote care in the daily workflow would be a valuable tool for the diagnosis and treatment of acute and chronic ocular conditions in this challenging clinical setting. | 2020-08-20 |
| 32813168 | The nature of the disease left certain clinical specialties more vulnerable than others, causing serious problems with organization of care of patients. | 2020-08-20 |
| 32813220 | Furthermore, the overall CFRs also significantly increased with higher levels of reported clinical symptoms, ranging from 14% for at least four symptoms, to 15% for 5 or 6 symptoms, and 21% for 7 or more symptoms. […] The chronic comorbid conditions were identified as dominating risk factors, which should be considered in an emergency disease management and treatment choices. […] There is urgent need to further enhance systematic and real-time sharing of epidemiologic data, clinical results, and experience to inform the global response to COVID-19. | 2020-08-20 |
| 32813238 | Current clinical studies have interpreted that angiotensin-converting enzyme 2 (ACE2) is the host receptor for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). […] Human ACE2 expression level and pattern in various tissues might be decisive for the vulnerability, symptoms, and treatment outcomes of the SARS-CoV-2 infection. […] Several clinical trials are currently ongoing worldwide as well as many other projects are in different stages of conceptualization and planning to facilitate the effective management of stroke patients with COVID-19 infection. | 2020-08-20 |
| 32813283 | Several randomized clinical trials (RCTs) that investigated the effectiveness of remdesivir for the treatment of coronavirus disease-2019 (COVID-19) have generated inconsistent evidence. […] The outcomes were clinical improvement between days 10 to 15 after randomization and clinical recovery during the follow-up period. […] Both 10-day and 5-day remdesivir regimens were associated with higher odds of clinical improvement (odds ratio [OR] of 10-day regimen: 1.35, 95% confidence interval [CI], 1.09-1.67); OR of 5-day regimen: 1.81, 95% CI, 1.32-2.45, and higher probabilities of clinical recovery (relative risk [RR] of 10-day regimen: 1.24, 95% CI, 1.07-1.43; RR of 5-day regimen: 1.47, 95% CI, 1.16-1.87 compared with placebo. […] Remdesivir may have clinical benefits among hospitalized COVID-19 persons. | 2020-08-20 |
| 32813298 | The aim of this study was to evaluate the clinical characteristics of patients with anaemia, and to further explore the relationship between anaemia and the severity of COVID-19. […] Clinical characteristics, laboratory findings, disease progression and prognosis were collected and analyzed. | 2020-08-20 |
| 32813575 | This has resulted in chaos in the clinical diagnosis of COVID-19. […] Our comments may provide some references for assay developers and aid clinical staff in choosing the appropriate class of test from the different tests available. | 2020-08-20 |
| 32813602 | While a higher severity of these patients could be expected from the addition of both respiratory and neurological injury, COVID-19 patients with strokes can present with mild or none respiratory symptoms. | 2020-08-20 |
| 32813683 | A high degree of clinical suspicion is required to detect TB with atypical presentation. […] Surgery may be necessary if there are compressive signs and symptoms secondary to CNS TB. […] Further studies are needed to understand the effects of COVID-19 on the clinical course of TB. | 2020-08-20 |
| 32813760 | Objective This study describes epidemiological and clinical features of patients with confirmed infection by SARS-CoV-2 diagnosed and treated at Hospital Israelita Albert Einstein , which admitted the first patients with this condition in Brazil. […] Demographic, clinical, laboratory and radiological data were analyzed. […] The most common symptoms upon presentation were fever (67.5%), nasal congestion (42.4%), cough (41.6%) and myalgia/arthralgia (36.3%). […] Regarding clinical treatment, the most often used medicines were intravenous antibiotics (84.7%), chloroquine (45.8%) and oseltamivir (31.9%). | 2020-08-20 |
| 32813843 | We were unable to find any review of the literature or analysis on ongoing registered clinical trials that reported diagnostic tests, therapeutics, vaccines and devices for COVID-19 along with estimated enrollment, participants’ ages, study type, start and completion date, status, treatment/intervention and country. […] A systematic search for clinical trials was conducted in the ClinicalTrials.gov database up to April 12, 2020. | 2020-08-20 |
| 32813844 | Different simulation strategies can be included in the diverse clinical care phases for these patients. […] Descriptive analysis on possible simulated clinical cases using different methodologies, thereby supporting suspected or confirmed COVID-19 patients. […] This was a reflective theoretical descriptive study on an educational program based on clinical simulation, with four practical phases at different performance and complexity levels. […] This program was designed for application at different Brazilian healthcare levels through different clinical simulation strategies. | 2020-08-20 |
| 32814065 | The SARS-CoV-2 pandemic raises many scientific and clinical questions. | 2020-08-20 |
| 32814566 | Finally, it discusses potential implications of specific clinical observations and considerations in COVID-19 patients on target oxygen saturation, such as diffuse systemic endothelitis and microthrombi playing an important pathogenic role in the wide range of systemic manifestations, exacerbation of hypoxic pulmonary vasoconstriction in the setting of pulmonary vascular endothelitis/microthrombi, the phenomenon of “silent hypoxemia” with some patients presenting to the hospital with severe hypoxemia disproportional to symptoms, and overburdened health systems and public health resources in many parts of the world with adverse implications on outpatient monitoring and early institution of oxygen supplementation. | 2020-08-21 |
| 32814635 | SARS-CoV-2 infection is clinically very heterogeneous, varying from asymptomatic to severe clinical conditions with a fatal outcome. | 2020-08-21 |
| 32814650 | Although the numbers of cases are increasing, no report about clinical manifestations, laboratory results, and imaging findings of the children infected with COVID-19 in Iran has been published. […] The aim of this study was to evaluate the epidemiological, clinical, and radiological and laboratory findings of 24 children who had proven SARS-CoV-2 infection and performed chest computed tomographic (CT) in Qom, Iran. […] Demographic information and clinical characteristics of the patients including signs and symptoms, chest CT scan manifestation, laboratory findings and clinical outcomes were collected. […] The most common presenting symptoms were fever (100%), dry cough (62.5%), tachypnea (29%), abdominal pain (21%), and vomiting (21%). | 2020-08-21 |
| 32814757 | However, pediatric clinical signs are less severe, making the onset diagnosis challenging to interpret. […] The variability of nasal olfactory symptoms in children and adolescents is intertwined with possible warning signs, including gastrointestinal, ocular, or dermatological symptoms. […] CASE REPORT The boy’s clinical history revealed that a family member was positive for SARS-CoV-2. […] CONCLUSIONS SARS-CoV-2 virus infection in children and adolescents can be asymptomatic, but it can also occur with fever, dry cough, fatigue, and gastrointestinal symptoms. […] Due to the unique immune characteristics of pediatric and adolescent patients, the correct interpretation of the gustatory and skin symptoms associated with specific laboratory tests for SARS-CoV-2 infection can lead to the most appropriate management and supportive care. | 2020-08-21 |
| 32814839 | Cumulative incidence of clinical improvement of ≥2 points in the ordinal scale was 82.4% (95% confidence interval, 71-93). […] Clinical improvement was not affected by low-flow versus high-flow oxygen support but was less frequent in patients with PaO2/FiO2 < 200 mmHg. […] Controlled clinical trials are necessary to establish efficacy of ruxolitinib in COVID-19. | 2020-08-21 |
| 32814926 | The main clinical characteristics of COVID-19 patients are revised here as compared to other coronavirus infections, such as Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), emphasizing clinical, diagnostic and therapeutic aspects. | 2020-08-21 |
| 32814955 | To evaluate the analytical and clinical performance of the automated Elecsys anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody (Elecsys Ab) assay on the Roche cobas e602 analyzer. […] Excellent clinical performance with respect to sensitivity, specificity, and positive and negative predictive values was observed. […] The Elecsys Ab assay is a precise and highly reliable automated platform for clinical detection of seropositivity in SARS-CoV-2 infection. | 2020-08-21 |
| 32815060 | To describe clinical characteristics of patients with COVID-19 who returned to the emergency department (ED) or required readmission within 14 days of discharge. | 2020-08-21 |
| 32815174 | Rapid diagnosis, isolation, and intensive clinical management are very important for all patients with COVID-19, especially for those with cardiac diseases as Brugada syndrome (BrS). […] We want to focus on some general rules, resulted from cases series and clinical practice, to be followed during the ICU management of patients with BrS and concomitant COVID-19 infection. | 2020-08-21 |
| 32815238 | Larger clinical registries and randomized clinical trials should be conducted to further explore the clinical and allograft outcomes associated with CCP use in this population. | 2020-08-21 |
| 32815293 | ED symptoms, coping strategies, socio-demographic data and COVID-19 concerns were collected by clinicians through a semi-structured telephone survey during lockdown. […] A deterioration in ED symptoms and general psychopathology (anxiety and depression), during lockdown, was associated with low self-directedness. | 2020-08-21 |
| 32815342 | Three to four weeks after the onset of symptoms, three commercial ELISAs and an in-house immunofluorescence test demonstrated antibodies to SARS-CoV-2. […] The in-house assays and one commercial assay gave congruent results, which were also consistent with the initial PCR and/or clinical evaluation, indicating prior infection in three of the five family members. | 2020-08-21 |
| 32815354 | Symptoms of delirium occurred in 26 patients (36 %) and was the most frequent non-respiratory complication. | 2020-08-21 |
| 32815356 | Thirty-seven of the residents had atypical symptoms, nine of them were asymptomatic at the time of diagnosis, and 21 died during the coronavirus infection. […] Spread of infection may have originated from staff, also before they displayed obvious symptoms, and contributed to extensive spread of SARS-CoV-2 in the three nursing homes. | 2020-08-21 |
| 32815406 | Despite several efforts in this direction and continuing clinical trials, no vaccine has been approved for it yet. | 2020-08-21 |
| 32815416 | Therapeutic anticoagulation may improve clinical outcomes through anti-thrombotic, anti-inflammatory and anti-viral mechanisms. | 2020-08-21 |
| 32815458 | We collected lower respiratory, urine, catheters, and blood samples according to clinical necessity and culture and mNGS were performed. […] Clinical and laboratory data were archived. | 2020-08-21 |
| 32815493 | Recent scientific evidence has indicated that the elderly have increased risk of COVID-19 infections, with over 70s and 80s being hardest hit - especially residents of care homes and in clinical settings, ethnic minorities, people who work indoors and those who are overweight and obese. | 2020-08-21 |
| 32815512 | Our research helps provide insights for clinical professionals in identifying the vulnerable groups to mental disorders in Peru. | 2020-08-21 |
| 32815513 | In 2 weeks, both patients demonstrated clinical improvement and recovery from COVID-19. […] Our findings suggest that even in cases of triple infection, clinical management together with respiratory therapy contributes to patient survival. | 2020-08-21 |
| 32815514 | Epidemiological and clinical information was obtained for all confirmed COVID-19 cases, whose symptom onset was from March 9 to April 5, 2020. | 2020-08-21 |
| 32815515 | Nonadherence to antiretroviral treatment may have been a factor in the clinical worsening of the patients. | 2020-08-21 |
| 32815519 | Chest X-ray plays a key role in diagnosis and management of COVID-19 patients and imaging features associated with clinical elements may assist with the development or validation of automated image analysis tools. […] We aimed to identify associations between clinical and radiographic features as well as to assess the feasibility of deep learning applied to chest X-rays in the setting of an acute COVID-19 outbreak. […] A retrospective study of X-rays, clinical, and laboratory data was performed from 48 SARS-CoV-2 RT-PCR positive patients (age 60±17 years, 15 women) between February 22 and March 6, 2020 from a tertiary care hospital in Milan, Italy. […] Clinical factors (age, symptoms, comorbidities) were investigated for association with opacity severity and also with placement of central line or endotracheal tube. […] Imaging characteristics were compared to clinical datapoints using the unpaired student’s t-test or Mann-Whitney U test. | 2020-08-21 |
| 32815523 | The clinical presentation of the disease may vary from mild illness to severe pneumonia such as acute respiratory distress syndrome (ARDS). | 2020-08-21 |
| 32815593 | Though many drugs have been proposed, none of them has shown particular efficacy in clinical trials. […] Retrospective and prospective clinical trials should be conducted to check the validity of the hypothesis. | 2020-08-21 |
| 32815633 | It is hoped that till the time new evidence based data is generated these communications may help spread awareness to help setup clinical protocols for other tertiary care settings. | 2020-08-21 |
| 32815769 | To assess the clinical performance of the ADAP assay, 57 PCR-confirmed COVID-19 patients and 223 control patients were tested. | 2020-08-21 |
| 32815845 | COVID-19 patients who are symptomatic on presentation to the emergency department and undergo surgical fixation have a 30% inpatient mortality rate compared with 12.5% for patients who are initially asymptomatic but later develop symptoms. […] Patients with COVID-19 symptoms on presentation should have surgery deferred until symptoms improve or resolve and should be reassessed for surgical treatment versus definitive nonoperative treatment with palliative care and/or hospice care. | 2020-08-21 |
| 32815846 | During the COVID-19 pandemic, the care of hip fracture patients remains a clinical priority. […] We collected data on time to surgery, Clinical Frailty Scale score, Nottingham Hip Fracture Score, COVID-19 infection status, 30-day mortality, and cause of death. | 2020-08-21 |
| 32815855 | Mental health related measurements included ASD, depression, anxiety, conflict experiences, hostility, and psychosomatic symptoms. […] SEM analyses revealed that emotional distress (i.e., anxiety and depressive symptoms) fully mediated the association between conflicts with ASD (the standardized indirect coefficient β=0.47, p=0.016). […] ASD was significantly associated with psychosomatic symptoms. […] Furthermore, ASD was found to be associated with psychosomatic symptoms as well as the hostility. | 2020-08-21 |
| 32816020 | Excellent results can be achieved through meticulous logistical planning, good communication, and maintaining high-level clinical care. | 2020-08-21 |
| 32816098 | We aimed to describe the clinical characteristics and outcomes of critically ill patients with COVID-19 and figure out the risk factors of mortality. […] Demographic data, symptoms, laboratory values, comorbidities, treatments, and clinical outcomes were collected. | 2020-08-21 |
| 32816193 | PHQ-9 screening identified 9% (n = 45) with mild depression symptoms, and 1% (n = 3) with moderate-to-severe depression symptoms. […] Young adults 20-24 years old had more mild to severe depressive symptoms than the younger age groups (p < 0.001). | 2020-08-21 |
| 32816200 | The viral infection due to the new coronavirus or coronavirus disease 2019 (COVID-19), which was reported for the first time in December 2019, was named by the World Health Organization (WHO) as Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV2), because of the very similar genome and also its related symptoms to SARS-CoV1. […] Since there is no specific treatment available for SARS-CoV2 infection, and or COVID-19, several clinical and sub-clinical studies are currently undertaken to find a gold-standard therapeutic regimen with high efficacy and low side effect. […] Based on the published scientific evidence published to date, we summarized herein the effects of different potential therapies and up-to-date clinical trials. | 2020-08-21 |
| 32816307 | To summarize clinical characteristics and outcomes among pregnant women hospitalized with COVID-19. | 2020-08-21 |
| 32816316 | The first identification of autochthonous transmission of SARS-CoV-2 in Italy was documented by the Laboratory of Clinical Microbiology, Virology and Bioemergencies of L. | 2020-08-21 |
| 32816437 | No other significant symptoms were reported. […] Conclusion Covid-19 infection typically presents with respiratory symptoms associated with fever and myalgia. […] It is important to be aware of the varied clinical presentations that may occur in Covid-19, including isolated gastrointestinal symptoms. | 2020-08-21 |
| 32816503 | The purpose of this study was to document the magnitude of that effect by examining (a) the amount of psychologists’ telepsychology use before the COVID-19 pandemic, during the pandemic, and anticipated use after the pandemic; as well as (b) the demographic, training, policy, and clinical practice predictors of these changes. […] Prior to the COVID-19 pandemic, psychologists performed 7.07% of their clinical work with telepsychology, which increased 12-fold to 85.53% during the pandemic, with 67.32% of psychologists conducting all of their clinical work with telepsychology. […] Psychologists projected that they would perform 34.96% of their clinical work via telepsychology after the pandemic. | 2020-08-21 |
| 32816541 | Finally, we suggest clinical and public health policy measures to ensure that people with disabilities are included in the planning of future pandemic-related efforts.The devastation evoked by the COVID-19 pandemic raises challenging dilemmas in bioethics. | 2020-08-21 |
| 32816615 | Recently, several scientific studies described the pathophysiology, clinical course, and the treatment of COVID-19 infection. […] The examination of the characteristics of COVID-19 infection revealed via the clinical studies suggests that Sumac extract could be useful in the treatment of COVID-19. | 2020-08-21 |
| 32816894 | Coronavirus disease 2019 (COVID-19) has fundamentally disrupted the practice of oncology, shifting care onto virtual platforms, rearranging the logistics and economics of running a successful clinical practice and research, and in some contexts, redefining what treatments patients with cancer should and can receive. […] In this article, we outline the importance of a focus on the effects of COVID-19 for oncology practice during and potentially after the pandemic, focusing on key shifts that are already evident, including: the pivot to online consultations, shifts in access to clinical trial and definitions of “essential care,” the changing economics of practice, and the potential legacy effects of rapidly implemented changes in cancer care. […] COVID-19 is reshaping oncology practice, clinical trials, and delivery of cancer care broadly, and these changes might endure well beyond the short- to mid-term of the active pandemic. | 2020-08-21 |
| 32816925 | The COVID-19 pandemic is a highly contagious viral illness which conventionally manifests primarily with respiratory symptoms. […] We report a case whose first manifestation of COVID-19 was pericarditis, in the absence of respiratory symptoms, without any serious complications. […] We present a case where pericarditis, in the absence of the classic COVID-19 signs or symptoms, is the only evident manifestation of the disease. | 2020-08-21 |
| 32816935 | Clinicians need to be aware of possible causes of reduced consciousness in COVID-19 patients, particularly as delirium appears to be a common complication, and revisit working diagnoses if the clinical picture does not fully fit. | 2020-08-21 |
| 32817221 | Numerous drugs are already approved for human use, and subsequently, there is a good understanding of their safety profiles and potential side effects, making them easier to fast-track to clinical studies in COVID-19 patients. […] Moreover, we evaluated two of these, chloroquine and chlorpromazine, in vivo using a mouse-adapted SARS-CoV model and found that both drugs protect mice from clinical disease.IMPORTANCE There are no FDA-approved antivirals for any coronavirus, including SARS-CoV-2. […] We found that neither drug inhibited viral replication in the lungs, but both protected against clinical disease. | 2020-08-21 |
| 32817231 | The coronavirus disease (COVID-19) pandemic has placed the clinical laboratory and testing for SARS-CoV-2 front and center in the worldwide discussion of how to end the outbreak. […] Clinical laboratories have responded by developing, validating, and implementing a variety of molecular and serologic assays to test for SARS-CoV-2 infection. | 2020-08-21 |
| 32817258 | Healthcare professionals cannot wait for published randomised controlled trials before they can start these rehabilitative interventions in daily clinical practice, as the number of post-COVID-19 patients increases rapidly. […] At least 70% agreement on directionality was necessary to make consensus suggestions. 76 experts (82%) reached consensus on all questions based upon indirect evidence and clinical experience on the need for early rehabilitation during the hospital admission, the screening for treatable traits with rehabilitation in all patients at discharge and 6-8 weeks after discharge, and around the content of rehabilitation for these patients. | 2020-08-21 |
| 32817272 | Based on the summarized experience of Chinese health workers, literature review and clinical practice, this article introduced donning and doffing of personal protective equipment (PPE) protocol and some keypoints of nursing critical care in patients with coronavirus disease 2019 (COVID-19): caring of patients requiring intubation and ventilation, venous thromboembolism (VTE) prevention, caring of patients on ECMO, caring for patients requiring enteral nutrition, psychological support and nursing management of COVID-19 ICU. | 2020-08-21 |
| 32817312 | Humanitas Clinical and Research Hospital (Rozzano-Milan, Lombardy, Italy) is a tertiary centre that has been converted to the management of COVID-19. | 2020-08-21 |
| 32817357 | Here, we performed a pilot study of four serological assays to assess the amounts of anti-SARS-CoV-2 antibodies in serum samples obtained from 491 healthy individuals before the SARS-CoV-2 pandemic, 51 individuals hospitalized with COVID-19, 209 suspected cases of COVID-19 with mild symptoms, and 200 healthy blood donors. | 2020-08-21 |
| 32817375 | Reports of success in early clinical studies were widely publicised by news outlets, politicians and on social media. […] Furthermore, subsequent studies have failed to demonstrate clinical benefit from either drug. […] Indeed, clinical trials have also been stopped early due to safety concerns over HCQ. | 2020-08-21 |
| 32817598 | Persons aged 16-23 years can receive serogroup B meningococcal vaccine (MenB), if determined to be appropriate through shared clinical decision-making. | 2020-08-21 |
| 32817689 | To identify investigated interventions for COVID-19 prevention or treatment via trial registry entries on planned or ongoing randomised clinical trials. […] We identified trial registry entries systematically via the WHO International Clinical Trials Registry Platform and 33 trial registries up to June 23, 2020. […] We included relevant trial registry entries for randomized clinical trials investigating medical preventive, adjunct or supportive therapies and therapeutics for treatment of COVID-19. […] An extraordinary number of randomized clinical trials investigating COVID-19 management have been initiated with a multitude of medical preventive, adjunctive and treatment modalities. | 2020-08-21 |
| 32818021 | Considering that the virus can be passed on directly from person to person through respiratory droplets, contact, fomites, and saliva, the oral and maxillofacial surgeons are exposed to COVID-19 in their daily clinical duties. | 2020-08-21 |
| 32818035 | A theoretical model was used in which one million people accessed the mobile application CoronApp-Colombia, which collects personal data, signs, symptoms and epidemiological links compatible with COVID-19. | 2020-08-21 |
| 32818071 | Clinical efficiency can be improved, reducing the number of emergency department (ED) referrals seen in VFC by 15-28% and face-to-face consultations by 65%. | 2020-08-21 |
| 32818075 | In addition to fever and respiratory symptoms, digestive symptoms also are observed in some patients with COVID-19. […] The aim of this study was to comprehensively investigate the digestive symptoms that occur in COVID-19 patients, and the potential pathogenic route of the SARS-CoV-2 infection in digestive tract organs (from the oral cavity to the gastrointestinal tract). […] We investigated the digestive symptoms of 48 patients with COVID-19 and explored ACE2 expression in digestive tract and lung cancers, based on a series of bulk and single-cell RNA sequencing data obtained from public databases. […] We found that 25% (12/48) of the patients with COVID-19 suffered from digestive symptoms, among which pharyngalgia (7/48) was the most common manifestation, followed by diarrhea (3/48), anorexia (3/48), and nausea (1/48). […] Our data might provide a theoretical basis for screening the SARS-CoV-2 susceptible population and for the clinical classification of treatment of patients with COVID-19. | 2020-08-21 |
| 32818119 | Our findings suggest that early use of tocilizumab might be beneficial in preventing clinical deterioration and intubation in select COVID-19 patients. | 2020-08-21 |
| 32818146 | Utilizing 34 348 severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) nucleic acid amplification test (NAAT) results from 2 health systems, we estimated the clinical sensitivity of a single SARS-CoV-2 NAAT. | 2020-08-21 |
| 32818151 | It is also used uncommonly as treatment for adenoviral conjunctivitis, yet the virucidal benefits of PVI have not been clearly documented in existing clinical management guidelines for ocular surface conditions. | 2020-08-21 |
| 32818235 | An abundance of clinical reports focused on specific laboratory parameters have been reported on COVID-19, but a systematic analysis synthesizing these findings has not been performed. […] Trends observed by serial laboratory measurements during hospitalization including progressive decrease of lymphocyte count, thrombocytopenia, elevated CRP, procalcitonin, increased liver enzymes, decreased renal function, and coagulation derangements were more common in critically ill patient groups and associated with a high incidence of clinical complications. […] Interpretation of the data reported in the studies reviewed here is limited due to study design (mostly retrospective), limited sample size, and a lack of defined clinical criteria. | 2020-08-21 |
| 32818434 | We review the epidemiology, causes, clinical features, and current treatment protocols for multisystem inflammatory syndrome in children and adolescents associated with COVID-19. | 2020-08-21 |
| 32818485 | Delay of the board examinations has caused angst as well as disruption of the timing of clinical rotations but may ultimately result in a shift of how the examinations are administered. | 2020-08-21 |
| 32818515 | The implication of this result is that detecting and isolating individuals with clinical symptoms of the pandemic alone (even if all of them are found) may not be sufficient to effectively curtail the pandemic. | 2020-08-21 |
| 32818576 | Moreover, since they can evolve fast and cross the species barrier, some of these viruses, such as influenza A and coronaviruses, have sometimes caused epidemics or pandemics and were associated with more serious clinical diseases and even mortality. […] In addition, the effects of probiotics on different aspects of immune responses and their antiviral properties in both pre-clinical and clinical contexts have been described in detail. | 2020-08-21 |
| 32818650 | Only through interdisciplinary research integrating biological, clinical and social data will we be able to provide new insights into the SARS-CoV-2 pandemic and inform actions aimed at reducing older adults’ vulnerability to COVID-19 or other similar pandemics in the future. | 2020-08-21 |
| 32818775 | Perceiving physical symptoms as COVID-19 was significantly associated with DASS stress subscale (B = 3.71, 95% CI: 1.01 to 6.40), DASS anxiety subscale (B = 3.95, 95% CI: 1.95 to 5.96), DASS depression subscale (B = 3.82, 95% CI: 0.97 to 6.67) and IES scale (B = 7.52, 95% CI: 3.58 to 11.45). […] Additionally, fear of infection, financial uncertainty, inadequate food supply, absence of physical exercise and limited or no recreational activity had significant association with stress, anxiety, depression and post-traumatic symptoms. | 2020-08-21 |
| 32818776 | Trauma exposure, COVID-19-related stressors, and psychological distress related to COVID-19 (anxiety, depression, and peritraumatic stress symptoms) were assessed. […] Individuals who had been exposed to trauma, and to CTS in particular, had elevated anxiety, depression, and peritraumatic stress symptoms compared to individuals without such a history or to survivors of non-ongoing traumatic events. […] CTS moderated the relations between PTSD symptoms, anxiety symptoms, and peritraumatic stress symptoms, with significantly stronger relations found among individuals exposed to CTS. | 2020-08-21 |
| 32818804 | The counts and clinical characteristics including laboratory findings and imaging of the patients with and without a subsequent stroke were recorded according to a predefined protocol. | 2020-08-21 |
| 32818852 | We analyzed NGS data derived from clinical samples of three Chinese patients infected with SARS-CoV-2, in order to identify small- and large-scale intra-host variations in the viral genome. | 2020-08-21 |
| 32818905 | Preclinical data suggest ACE2 might be downregulated after SARS-CoV-2 binding, and treatments that increase ACE2 may prevent cardiopulmonary injury. […] Metformin is a widely available anti-diabetic agent that has an excellent safety profile, and clinical and preclinical data suggest metformin may offer cardiopulmonary protection in COVID-19 via enhanced ACE2 expression. | 2020-08-21 |
| 32818962 | There is a proliferation of clinical trials worldwide to find effective therapies for patients diagnosed with novel coronavirus disease-2019 (COVID-19). […] The endpoints that are currently used to evaluate the efficacy of therapeutic agents against COVID-19 are focused on clinical status at a particular day or on time to a specific change of clinical status. […] To provide a full picture of the clinical course of a patient and make complete use of available data, we consider the trajectory of clinical status over the entire follow-up period. […] We also show how to combine the evidence of treatment effects on the occurrences of various clinical events. | 2020-08-21 |
| 32819125 | To investigate the epidemiology and clinical characteristics of patients infected with coronavirus disease 2019 (COVID-19) in Weifang, China. […] On admission, patients’ symptoms and results of laboratory tests and imaging were analyzed. […] The most common COVID-19 symptoms were fever, weakness, dry cough, and cough sputum. | 2020-08-22 |
| 32819219 | The benign urology slots included 323 (28.8%) andrology, 193 (17.2%) stones and 603 (54%) lower urinary tract symptoms (LUTS) slots. […] Reorganisation and flexibility of healthcare delivery is paramount in these troubled times and will allow clinical activity without compromising patient safety. | 2020-08-22 |
| 32819220 | Here, we describe the development, validation and clinical evaluation of a protein micro-array as a quantitative multiplex immunoassay that can identify S and N-directed SARS-CoV-2 IgG antibodies with high specificity and sensitivity and distinguish them from all currently circulating human coronaviruses. […] To assess its potential role for both SARS-CoV-2 patient diagnostics and population studies, we evaluated a large heterogeneous COVID-19 cohort (n=330) and found an overall sensitivity of 89% (≥ 21 days post onset symptoms (dps)), ranging from 86% to 96% depending on severity of disease. […] Overall, we present the development and extensive clinical validation of a multiplex coronavirus serological assay for syndromic testing, to answer research questions regarding to antibody responses, to support SARS-CoV-2 diagnostics and to evaluate epidemiological developments efficiently and with high-throughput. | 2020-08-22 |
| 32819266 | Whereas the majority of disease presents with mild symptoms that can be treated as outpatients, severely ill COVID-19 patients and patients presenting with similar symptoms cross their ways in the emergency department. […] Especially, the variety of symptoms is challenging with primary triage. […] We conducted a retrospective analysis of 314 consecutive inpatient patients who presented with possible symptoms of COVID-19 in a German emergency department between March and April 2020 and were tested with a SARS-Cov-2 nasopharyngeal swab. […] Clinical parameters, Manchester Triage System categories, and lab results were compared between patients with positive and negative test results for SARS-Cov-2. […] We did not find any laboratory parameter to distinguish safely between patients with COVID-19 and those with similar symptoms. […] Dysgeusia was the only clinical symptom that was significantly more frequent among COVID-19 patients. […] However, no valid parameters could be found to distinguish clinically between COVID-19 and other diseases with similar symptoms. […] German Clinical Trials registry, DRKS00021675. | 2020-08-22 |
| 32819292 | This controlled trial has been conducted on critically ill COVID-19 patients admitted in the state hospital affiliated to Babol University of Medical Sciences, Iran who received different antiviral and antibacterial drugs, and different modalities of respiratory treatments and did not have positive clinical improvement. […] The research protocol has been registered in the website of Iranian Registry of Clinical Trials with the reference number IRCT20150704023055N2 . | 2020-08-22 |
| 32819485 | The authors propose a detailed phased-in approach that considers clinical, patient-centered, and operational strategies to safely and effectively reboot catheterization laboratory programs during these unprecedented times. | 2020-08-22 |
| 32819868 | Students took our previously validated free response clinical skills exam (CSE) at the end of the scheduled clerkship as an open-book exam to eliminate any concern for breaches in the honor code and then grades were adjusted based on historic norms. […] Secondary outcomes included clinical evaluations and the percentage of students who received grades of Honors, High Pass, and Pass. | 2020-08-22 |
| 32819897 | Multiple cardiovascular and pulmonary incidental findings of clinical relevance were identified in our patient population. | 2020-08-22 |
| 32819898 | The extent of its clinical picture is actively evolving and has yet to be fully elucidated. | 2020-08-22 |
| 32820143 | We collected clinical and patient-reported data on quality of life, physical functions, the sensation of pain, psychological well-being, and symptoms while taking into account the degree of chronicity of the conditions, the level of the patient’s pain, and his hospitalization in an isolation ward. […] We stabilized clinical parameters related to the patient’s main underlying health conditions (blood glucose and pain levels and oxygen saturation). | 2020-08-22 |
| 32820179 | The lack of clinical metadata available prevented our investigation of association between viral clade and disease severity phenotype. […] Future work that can leverage clinical outcome data with both viral and human genomic diversity is needed to monitor the pandemic. | 2020-08-22 |
| 32820236 | We aimed to examine whether preceding use of ACEIs and ARBs affected the clinical manifestations and prognosis of COVID-19 patients. | 2020-08-22 |
| 32820248 | The scientific and clinical community is in a race to define and develop effective preventions and treatments. […] The major features of disease are described but clinical trials have been hampered by competing interests, small scale, lack of defined patient cohorts and defined readouts. | 2020-08-22 |
| 32820725 | All gargle samples were positive and comparable to their corresponding swab samples irrespective of the symptoms and duration of illness. | 2020-08-22 |
| 32820746 | Influenza vaccination of persons aged ≥6 months to reduce prevalence of illness caused by influenza will reduce symptoms that might be confused with those of COVID-19. | 2020-08-22 |
| 32820801 | In this review, we present the main aspects related to the origin, classification, etiology and clinical impact of SARS-CoV-2. […] Furthermore, the potential involvement of these signaling pathways in evoking the onset and progression of COVID-19 symptoms in these organ systems are presently discussed. | 2020-08-22 |
| 32820823 | Despite descriptions of various cardiovascular manifestations in patients with coronavirus disease 2019 (COVID-19), there is a paucity of reports of new onset bradyarrhythmias, and the clinical implications of these events are unknown. […] A retrospective review of their presentations and clinical course was performed. […] In some patients, bradyarrhythmias occurred prior to the onset of respiratory symptoms. | 2020-08-22 |
| 32820868 | Then, the recent clinical trials and the therapeutic benefits of MSCs in coronavirus-induced ARDS are critically reviewed. […] Despite promising results in the preclinical and clinical applications of MSC therapy for coronavirus infections, the controversy still exists, and thus further investigation is required to understand the efficacy of these therapies. | 2020-08-22 |
| 32820884 | Many experimental and clinical studies have proven that the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has tropism to the nervous system. […] Apart from typical symptoms of COVID-19 related to the involvement of the respiratory system, neurological manifestations such as headache, dizziness, myalgia, anosmia, ageusia, encephalopathy, encephalitis, stroke, epileptic seizures, rhabdomyolysis and the Guillain-Barre syndrome (GBS) are associated with SARS-CoV-2 infection. | 2020-08-22 |
| 32821027 | Introduction: With support from emergency department (ED) leadership, our institution rapidly deployed telemedicine in a novel approach to large-scale ED infectious disease management at NewYork-Presbyterian/Weill Cornell Medical Center (NYP/WCMC) and NewYork-Presbyterian/Lower Manhattan Hospital (NYP/LMH). […] This initiative increased provider/patient communication and attention to staff safety, improved palliative care and patient support services, lowered PPE consumption, and streamlined clinical workflows. | 2020-08-22 |
| 32821086 | In different clinical trials, efficacy of remdesivir (GS-5734) against Ebola virus has been demonstrated. […] Several clinical trials are ongoing for the management of COVID-19 using remdesivir. | 2020-08-22 |
| 32821132 | Clinical manifestations, laboratory indicators, and follow-up CT data were evaluated. […] When new lesions developed, 6 (60.0%) patients developed new symptoms or had aggravated symptoms and 3 (30.0%) had decreased lymphocyte count. […] Patients with worsening symptoms had higher involvement of lung segments (mean: 6.5 ± 5.0, range: 1-13) than asymptomatic patients (mean: 1.5 ± 0.6, range: 1-2) (P = 0.057). […] Repeat CT is necessary for monitoring the disease, especially when patients have worsening symptoms or laboratory indicators. | 2020-08-22 |
| 32821174 | Clinical presentations of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vary among patients, which make a confusing challenge for clinicians to diagnose the disease. […] While the disease is not rare, but the symptoms may be atypical in children. | 2020-08-22 |
| 32821175 | Because of variations in the patient’s clinical features, we decided to perform hemoperfusion to remove cytokines. […] Afterward, his clinical status improved significantly, and he was discharged in stable condition. | 2020-08-22 |
| 32821192 | Currently, the COVID-19 pandemic has a critical impact on clinical education, and it has resulted in the widespread disruption of clinical assessment. […] Clinical mentors and students in all the health professions are working within the most troublesome of circumstances in the hospital-based educational settings. […] A key challenge for medical educators is to simulate the clinical encounters at this unprecedented time, and this emphasized the necessity of applying virtual simulation-based educational tools in clinical education. […] It also has discussed the future implications and potencial challenges of incorporating simulation-based virtual learning technologies into the medical curriculum, for the future of clinical education, and students’ or residents’ competency evaluation. | 2020-08-22 |
| 32821237 | We show that, when facemasks are used by the public all the time (not just from when symptoms first appear), the effective reproduction number, Re , can be decreased below 1, leading to the mitigation of epidemic spread. | 2020-08-22 |
| 32821332 | Hawks L et al. raise four concerns that need to be considered when developing public health and clinical responses to COVID-19 to protect prisoners. | 2020-08-22 |
| 32821381 | Despite uncertainties in the viral determinants and pathogenesis, it is crucial to accurately inspect all available evidence to construct accurate clinical guidelines for optimised patient care. […] But contradictory evidence exists on the clinical use of CQ/HCQ, either alone or in combination with azithromycin. […] As of now, there is no compelling clinical evidence on CQ, HCQ, and azithromycin in COVID-19 and the available evidence is limited to methodologically inferior non-randomised studies. | 2020-08-22 |
| 32821441 | Simulation has been proven to be pivotal for both healthcare provider learning and systems integration in the context of testing and integrating new processes, workflows, and rapid changes to practice (e.g., new cognitive aids, checklists, protocols) and changes to the delivery of clinical care. | 2020-08-22 |
| 32821538 | The aim of this study was to evaluate knowledge, attitudes, and clinical education of dental students about COVID-19 pandemic. […] A total of 355 pre-clinical and clinical dental students (242 and 113, respectively, comprising 190 females and 165 males) at Fırat University Dentistry Faculty, in Elazığ, Turkey answered an online questionnaire about the biosafety procedures for and their attitudes to and knowledge of COVID-19. […] Both the clinical and preclinical students were found to be afraid of infecting themselves and their environment with COVID-19, and the difference between them was statistically significant. […] Three quarters (74.9%) of the participants responded yes to the question of whether they thought that experiences related to COVID-19 affected them psychologically, with the differences between gender and clinical status were statistically significant. […] Responses to the question of which clinical rotation worried them more were 29.9% endodontics, 25.1% oral and maxillofacial surgery, 16.3% prosthesis, 15.2% periodontology, 6.8% restorative dentistry, 3.9% oral diagnosis and radiology, 1.7% pedodontics, and 1.1% orthodontics, with a significant difference between the preclinical and clinical students. […] Regarding the measures applied by the clinical students in their clinical rotation, the responses were 100% gloves and 100% mask (with 11.5% FFP3/N95 mask), 73.6% face protective shield and 37.1% safety glasses, and 49% bonnet and 16.8% disposable box, with 90.2% frequent hand washing, and 86.7% frequent hand antiseptic usage. | 2020-08-22 |
| 32821607 | There is currently no FDA-approved medical treatment or vaccine for COVID-19, so a variety of drugs and medicinal therapies have been repurposed for use in hospital settings and clinical studies while the medical community waits for a medication to be approved and standardized. | 2020-08-22 |
| 32821612 | Similar symptoms, signs, and laboratory abnormalities between coronavirus disease 2019 (COVID-19) and pulmonary embolism (PE) creates a diagnostic challenge to every physician, and emerging data show an association between COVID-19, hypercoagulable state, and venous thromboembolism. | 2020-08-22 |
| 32821623 | No patients presented post-operatively with COVID-19 symptoms and at 30 days there had not been any identified COVID-19 cases. | 2020-08-22 |
| 32821637 | Individuals living in Marion County with no symptoms of coronavirus 2019 disease (COVID-19) within seven days of enrollment were eligible for this cross-sectional household study. […] The child and family members all tested negative for infection 10 and 20 days after the first test, and none developed symptoms of COVID-19 for 20 days after testing. | 2020-08-22 |
| 32821783 | In keeping with federal policy, our state’s laws do not permit medical abortion via telemedicine, not even during the coronavirus disease 2019 (COVID-19) outbreak, a decision that endangers the lives of women, clinical staff, nurses, and doctors. | 2020-08-22 |
| 32821882 | Through examining prior structure-activity studies on prodrug forms and the choices that led to development of remdesivir and other clinical drugs and drug candidates, a better understanding of their ability to distribute to the planned site of action, such as the liver, plasma, PBMCs, or peripheral tissues, can be gained. | 2020-08-22 |
| 32821901 | The pre-disease Clinical Frailty Scale (CFS) was assessed at hospital admission. | 2020-08-22 |
| 32821902 | Clinical findings were abstracted from medical records. […] Eight patients (7 men, 87.5%; median age of 79 years, range, 69-96) died within a median of 17 days (range, 6-100) from onset of symptoms. | 2020-08-22 |
| 32821909 | The aim of this rapid review is to describe the satisfaction, clinic productivity, clinical benefit, and costs associated with the virtual geriatric clinic model of care. […] Four subdomains were focused on: satisfaction with the virtual geriatric clinic, clinic productivity, clinical benefit to patients, costs and any challenges associated with the virtual clinic process. […] Clinical benefits included successful polypharmacy reviews, and reductions in acute hospitalisation rates. | 2020-08-22 |
| 32821935 | We offered SARS-CoV-2 reverse transcription-PCR and antibody (Abbott ARCHITECT IgG) testing, regardless of symptoms, to all residents (≥4 years) and workers in a San Francisco census tract (population: 5,174) at outdoor, community-mobilized events over four days. | 2020-08-22 |
| 32821939 | Remdesivir demonstrated clinical benefit in a placebo-controlled trial in patients with severe coronavirus disease 2019 (COVID-19), but its effect in patients with moderate disease is unknown. […] To determine the efficacy of 5 or 10 days of remdesivir treatment compared with standard care on clinical status on day 11 after initiation of treatment. […] The primary end point was clinical status on day 11 on a 7-point ordinal scale ranging from death (category 1) to discharged (category 7). […] An odds ratio greater than 1 indicates difference in clinical status distribution toward category 7 for the remdesivir group vs the standard care group. […] On day 11, patients in the 5-day remdesivir group had statistically significantly higher odds of a better clinical status distribution than those receiving standard care (odds ratio, 1.65; 95% CI, 1.09-2.48; P = .02). […] The clinical status distribution on day 11 between the 10-day remdesivir and standard care groups was not significantly different (P = .18 by Wilcoxon rank sum test). […] Among patients with moderate COVID-19, those randomized to a 10-day course of remdesivir did not have a statistically significant difference in clinical status compared with standard care at 11 days after initiation of treatment. […] Patients randomized to a 5-day course of remdesivir had a statistically significant difference in clinical status compared with standard care, but the difference was of uncertain clinical importance. | 2020-08-22 |
| 32822060 | Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a global pandemic with a wide spectrum of clinical signs and symptoms. | 2020-08-22 |
| 32822224 | Within a given disease area, the texture and material of the lung parenchyma in the XCAT were modified to match the properties observed in the clinical images. | 2020-08-22 |
| 32822280 | As the coronavirus pandemic started, we rapidly transitioned a preclinical social justice and health systems sciences course at our medical school to asynchronous, remote learning. | 2020-08-22 |
| 32822290 | This study shows that severe acute respiratory syndrome coronavirus 2 is infectious in closed settings, that subclinical infection is common, and that close contact is key for transmission. | 2020-08-22 |
| 32822413 | To determine clinical factors of a poor prognosis in patients with COVID-19 infection. […] Examination of the medical records of patients with COVID-19 infections confirmed by polymerase chain reaction. […] Determining the clinical, biological and radiological characteristics of patients with suspected COVID-19 infection will be key to early treatment and isolation and the tracing of contacts. | 2020-08-22 |
| 32822430 | Evidence-based characterization of the diagnostic and prognostic value of the hematological and immunological markers related to the epidemic of Coronavirus Disease 2019 (COVID-19) is critical to understand the clinical course of the infection and to assess in development and validation of biomarkers. | 2020-08-22 |
| 32822564 | We investigated the effect of this deletion on the clinical features of infection. […] We collected clinical, laboratory, and radiological data from patients’ electronic medical records and serial blood and respiratory samples taken during hospitalisation and after discharge. […] The observed clinical effects of deletions in ORF8 could have implications for the development of treatments and vaccines. | 2020-08-22 |
| 32822577 | We estimated the reduction in the effective reproduction number (R) achieved by testing and isolating symptomatic individuals, regular screening of high-risk groups irrespective of symptoms, and quarantine of contacts of laboratory-confirmed cases identified through test-and-trace protocols. […] If all individuals with symptoms compatible with COVID-19 self-isolated and self-isolation was 100% effective in reducing onwards transmission, self-isolation of symptomatic individuals would result in a reduction in R of 47% (95% uncertainty interval [UI] 32-55). […] Weekly screening of health-care workers and other high-risk groups irrespective of symptoms by use of PCR testing is estimated to reduce their contribution to SARS-CoV-2 transmission by 23% (95% UI 16-40), on top of reductions achieved by self-isolation following symptoms, assuming results are available at 24 h. […] The effectiveness of test and trace depends strongly on coverage and the timeliness of contact tracing, potentially reducing R by 26% (95% UI 14-35) on top of reductions achieved by self-isolation following symptoms, if 80% of cases and contacts are identified and there is immediate testing following symptom onset and quarantine of contacts within 24 h. | 2020-08-22 |
| 32822746 | Novel coronavirus disease (COVID-19) can have variety of cardiac manifestations; however, less is known about the prevalence, clinical characteristics and outcomes of bradyarrhythmias in patients with COVID-19. | 2020-08-22 |
| 32822752 | In the setting of a pandemic, with heightened precautions and limited visitation by loved ones, all members of the clinical team are called to utilize compassionate listening and communication skills to address the pervasive isolation and grief of those in their care. | 2020-08-22 |
| 32822775 | CLINICAL TRIAL REGISTRATION: url: https://www.clinicaltrials.gov. | 2020-08-22 |
| 32822883 | We describe the clinical course and examine factors associated with outcomes among patients hospitalized with COVID-19 in Germany. […] We examined demographic characteristics, comorbidities and clinical outcomes. | 2020-08-22 |
| 32822911 | In this review, we explore the events associated with SARS-CoV-2 pathogenesis and host immunopathological reactivity due to the clinical manifestations of this coronavirus infection. […] In cases of co-morbidity, therapies related to the management of associated disease conditions could ameliorate those clinical manifestations. | 2020-08-22 |
| 32823144 | Better insights into how chloroquine targets the host’s cellular and immune responses may help to develop applications against to new pathogens and diseases, and perhaps even restore the clinical utility of chloroquine against malaria. | 2020-08-22 |
| 32823148 | The use of disease-modifying therapies (DMTs) in multiple sclerosis (MS) could affect COVID-19 outcomes by modulating the immune response, which, in turn, might favor viral replication and/or confer protection from COVID-19 induced inflammatory response CASE REPORT: We report on two MS patients treated with cladribine, with heterogeneous demographics and clinical features, who developed mild or no symptoms from COVID-19 and produced anti-SARS-CoV-2 antibodies, notwithstanding low lymphocyte levels. […] Benign COVID-19 clinical course and anti-SARS-CoV-2 antibody production can occur in MS patients with lymphopenia, suggesting the possibility to respond to COVID-19 vaccination, once available, in this vulnerable population. | 2020-08-22 |
| 32823497 | Computational methods and laboratory studies support the need to undertake apposite preclinical, epidemiological, and experimental studies on the potential benefits of citrus fruit components for the prevention of infectious diseases, including COVID-19. | 2020-08-23 |
| 32823540 | With the increase in the number of cases worldwide, neurological symptoms and psychological illnesses from COVID-19 have increasingly upsurged. […] The COVID-19 pandemic not only affected people with pre-existing mental and affective illnesses, but also healthy individuals with anxiety, worrying, and panic symptoms, and fear conditioning. […] Owing to the significance of neurological and psychological events, the present perspective has been an attempt to disseminate the impact of COVID-19 on neural injury through inflammation, and its interrelation with psychological symptoms. | 2020-08-23 |
| 32823591 | Based on the clinical observation of low prevalence of smoking among hospitalized COVID-19 patients, we examined and identified a “toxin-like” amino acid (aa) sequence in the Receptor Binding Domain of the Spike Glycoprotein of SARS-CoV-2 (aa 375-390), which is homologous to a sequence of the Neurotoxin homolog NL1, one of the many snake venom toxins that are known to interact with nicotinic acetylcholine receptors (nAChRs). | 2020-08-23 |
| 32823727 | The aim of this survey is to evaluate knowledge about clinical importance of COVID-19, disease management, prevention measures, and anxiety level during pandemic among patients with IBD. […] The questionnaire consisted of five sections: (1) anthropometric, demographic and clinical characteristics, (2) knowledge about clinical importance of COVID-19, (3) IBD management, (4) prevention measures, (5) anxiety level during pandemic. […] Most patients reported high knowledge about clinical importance of COVID-19 (80%), IBD management (72%), and prevention measures (97%). […] High education level was independently associated with high knowledge about clinical importance of COVID-19 (odds ratio [OR] 5, 95% confidence interval [CI] 1.49-16.6, p = 0.009) and older age (OR 1, 95%, CI 1.01-1.1, p = 0.01), while the receipt of e-format educational material with low knowledge about clinical importance of COVID-19 (OR 3, 95%, CI 1.08-9.3, p = 0.03). […] Conclusions: High educational level and aging promote knowledge about clinical importance of COVID-19, while e-format educational material does not. | 2020-08-23 |
| 32823866 | The global coronavirus disease 2019 (COVID-19) pandemic has increased the demand for accurate, easy-to-use, rapid, and cost-effective antigen tests for clinical application. | 2020-08-23 |
| 32823901 | Fever, dry cough, sore throat, pneumonia, septic shock, and ground-glass opacities are the foremost clinical manifestations of COVID-19. […] Moreover, very few reports have addressed the clinical features and current status of treatment for COVID-19; we have adequately addressed these topics in detail in this review. […] Finally, a detailed account of clinical trials of vaccines and other therapeutics currently in progress has been delineated. | 2020-08-23 |
| 32823999 | Sarcomas are rare cancers with a spectrum of clinical needs and outcomes. | 2020-08-23 |
| 32824122 | In addition, the digestive symptoms of COVID-19 can be difficult to distinguish from the activation of IBD. | 2020-08-23 |
| 32824272 | Here we compare Liverpool amplification, ARTIC amplification, and bait capture using clinical diagnostics samples. […] While only two clinical samples were examined in this comparative analysis, both the Liverpool and ARTIC amplification methods showed differing efficacy for high and low concentration samples. | 2020-08-23 |
| 32824594 | As emerged from our analysis, poor housing is associated with increased risk of depressive symptoms during lockdown. […] In particular, living in apartments <60 m2 with poor views and scarce indoor quality is associated with, respectively, 1.31 (95% CI: 1046-1637), 1.368 (95% CI: 1166-1605), and 2.253 (95% CI: 1918-2647) times the risk of moderate-severe and severe depressive symptoms. | 2020-08-23 |
| 32824674 | The novel coronavirus disease 2019 (COVID-19) shows a wide spectrum of clinical presentations, severity, and fatality rates. […] Clinical studies on TMPRSS2 inhibitors, such as camostat, nafamostat, and bromhexine, are ongoing. | 2020-08-23 |
| 32824683 | We aimed to describe their clinical features comparing confirmed and suspected non-confirmed COVID-19 cases during the Spanish epidemic peak. […] In comparison with (-)COVID-19 patients, (+)COVID-19 showed higher frequency of typical viral symptoms (cough, dyspnea, asthenia and myalgias), pneumonia (88.2% vs. […] Time from symptoms onset to admission was longer in patients who finally died than in survivors (8.5 vs. […] In KT and MHD patients, (+)COVID-19 shows more clinical severity than suspected non-confirmed cases. | 2020-08-23 |
| 32824753 | Given that therapeutic avenues are now highly warranted, we also discuss the immunotherapies available to manage the infection and the clinical outcomes. | 2020-08-23 |
| 32824827 | Here, we provide a procedure for SARS-CoV-2 detection for diagnostic purposes from clinical samples in the setting of a basic research molecular biology lab. […] The procedure details the necessary steps for daily analysis of up to 500 clinical samples with a team composed of 12 experienced researchers. […] The protocol has been designed to rely on widely available reagents and devices, to cope with heterogeneous clinical specimens, to guarantee nucleic acid extraction from very scarce biological material, and to minimize the rate of false-negative results. | 2020-08-23 |
| 32825182 | Initially, it was thought that the main health threat was associated with respiratory system failures, but since then, SARS-CoV-2 has been linked to a broad spectrum of symptoms indicating neurological manifestations, including ischemic stroke. | 2020-08-23 |
| 32825269 | Simulated video consultations, a teaching tool based on high-fidelity simulations, were implemented in response to the necessary adaptation of high-fidelity clinical simulation sessions to the online or virtual modality during the university closure due to the COVID-19 confinement. […] Nursing students should be trained in this modality of healthcare to face the challenge brought on by its increased use in healthcare services, beyond the specific adaptation of clinical simulation sessions due to the closure of universities during this pandemic. | 2020-08-23 |
| 32825283 | Many new drugs are being developed, and several traditional drugs that were originally indicated or proposed for other diseases are likely to be effective in treating COVID-19, but their safety and efficacy are controversial, under study, or in clinical trial phases. | 2020-08-23 |
| 32825295 | We focused on SARS-CoV-2-positive patients, reporting on the clinical characteristics of the cancer and the infection. | 2020-08-23 |
| 32825383 | Although these innovations are promising and have been associated with a significant reduction in health costs, their application in clinical practice is limited. | 2020-08-23 |
| 32825438 | Both medical sciences and biomedical research have also been challenged, consequently leading to a large number of clinical trials and vaccine initiatives. | 2020-08-23 |
| 32825563 | Clinical and demographic data were collected through the national platform for COVID-19 surveillance. | 2020-08-23 |
| 32825816 | However, it is difficult to launch clinical trials in the unpredictable environment of an outbreak. […] We searched PubMed for all clinical data (including clinical trial, observational and case series) describing treatment for patients with influenza A(H1N1)pdm09 and ClinicalTrials.gov for research that aimed to enrol patients with the disease. […] Five hundred ninety-two patients received treatment (or placebo) as participants in a registered interventional clinical trial with results publicly available. […] Rapid scaling of clinical trials is critical for generating a quality evidence base during pandemics. | 2020-08-23 |
| 32825892 | A group of senior doctors with vast clinical experience met on 19th July’20 under the aegis of Academy of Advanced Medical Education. | 2020-08-23 |
| 32826081 | As the COVID-19 pandemic continues to spread worldwide, it is crucial that we determine populations that are at-risk and develop appropriate clinical care policies to protect them. […] Here, we review the available literature on newborns born to infected mothers and show that newborns of mothers with positive/suspected SARS-CoV-2 infection rarely acquire the disease or show adverse clinical outcomes. | 2020-08-23 |
| 32826279 | Our vision was to set up a safe space for staff away from clinical noise to enable and encourage mindfulness and psychological resilience through a calm and serene environment. | 2020-08-23 |
| 32826322 | None of the crew members with neutralizing antibody titers showed evidence of bona fide viral infection or experienced any symptoms during the viral outbreak. | 2020-08-23 |
| 32826331 | There are currently no immunotherapies with proven clinical efficacy and understanding of the molecular mechanisms of CRS pathogenesis is limited. | 2020-08-23 |
| 32826431 | Great efforts are being made worldwide to identify the specific clinical characteristics of infected critically ill patients that mediate the associated pathogenesis, including vascular dysfunction, thrombosis, dysregulated inflammation, and respiratory complications. […] Understanding the physiopathology of the disease that lead to sepsis after severe acute respiratory syndrome coronavirus 2 infection is a current clinical need to improve intensive care-applied therapies applied to critically ill patients. | 2020-08-23 |
| 32826432 | However, the clinical effectiveness of early high-flow nasal oxygen treatment in patients with coronavirus disease 2019 with acute hypoxemic respiratory failure has not been explored. | 2020-08-23 |
| 32826520 | As hospitals and medical schools confronted coronavirus disease 2019 (COVID-19), medical students were essentially restricted from all clinical work in an effort to prioritize their safety and the safety of others. […] As we acclimate to our new clinical environment and medical students return to the frontlines of health care, we advocate for medical students to be reconsidered as physicians-in-training who bring valuable skills to patient care and to maintain their status as valued team members despite surges in COVID-19 or future pandemics. […] In this commentary, we discuss factors that led to students’ being excluded from this pandemic despite being required at the bedside during prior U.S. public health crises this past century, and we review educational principles that support maintaining students in clinical environments during this and future pandemics. | 2020-08-23 |
| 32826546 | In phase 2, surveillance was restricted to employees with confirmed COVID-19, aiming at monitoring of symptoms and following hospitalizations. | 2020-08-23 |
| 32826562 | The research tool assessed HIV follow-up, psychosocial well-being, COVID-19 (flu-like) symptoms and prevention measures. […] Factors associated with a reduced risk of experiencing flu-like symptoms included flu vaccination during the past 12 months (P = 0.005) and adaptations of HIV care during the COVID-19 pandemic (P = 0.010). | 2020-08-23 |
| 32826572 | We reviewed data on the prevalence and clinical outcomes of COVID-19 in patients with IBD. […] Therapies using antitumor necrosis factor-α agents have been associated with better clinical outcomes. | 2020-08-23 |
| 32826625 | The impact of hemi-diaphragmatic function impairment on clinical outcomes is yet to be established. | 2020-08-23 |
| 32826642 | The clinical features of this syndrome seem to overlap between Kawasaki disease, toxic shock syndrome, and myocarditis. | 2020-08-23 |
| 32826719 | Forty-five percent reported symptoms corresponding to characteristics of COVID-19. | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826724 | The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). | 2020-08-23 |
| 32826796 | Data on the clinical course of COVID-19 in immunosuppressed patients are limited, and the optimal management strategy for these patients is yet unclear. […] Demographic, clinical, and treatment data were extracted from the electronic patient files. […] Patients reported fever (61%), cough (43%), diarrhea (31%), and upper respiratory symptoms (29%). | 2020-08-23 |
| 32826818 | Epidemiologic data, clinical features, treatments, and outcomes were collected and analyzed. […] Early hypoxemia, subsequent hypercapnia, pulmonary hypertension, and finally pulmonary fibrosis were notable in the clinical course of acute respiratory distress syndrome (ARDS). | 2020-08-23 |
| 32826924 | Thus, Ad5-S-nb2 is a promising candidate vaccine and warrants further clinical evaluation. | 2020-08-23 |
| 32827020 | The proportion of infected children is significantly less compared to adults with the majority of them showing mild symptoms. […] This article has summarized the clinical characteristics of children with coronavirus disease 2019 based on published case reports. | 2020-08-23 |
| 32827081 | Therapeutic clinical and preclinical studies using cultured cells are on the rise, especially now that the World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) a “public health emergency of international concern”, in January, 2020. […] Thus, this study aims to review the outcomes of ongoing clinical studies on stem cells in Severe Acute Respiratory Syndrome (SARS), Acute Respiratory Distress Syndrome (ARDS), and Middle East Respiratory Syndrome (MERS). […] Only three clinical trials related to stem cells are considered complete, whereby two are in Phase 1 and one is in Phase 2. […] With the COVID-19 boom, many clinical trials are being carried out using different sources with an emphasis on MSC-based therapy used to inhibit inflammation. […] We look forward to the results of the ongoing clinical trials to find a treatment for the disease. […] Stem cells used in the current clinical studies are a new therapeutic promise for COVID-19 where pharmacological treatments seem insufficient.Graphical Abstract. | 2020-08-23 |
| 32827082 | On further clinical evaluation, the swab was found endoscopically, lodged between the left inferior turbinate and nasal floor, and was removed by an otorhinolaryngologist. […] Recognition that aluminum foreign bodies may be difficult to visualize radiographically and optimization of radiograph acquisition technique may help guide clinical management in unusual cases. | 2020-08-23 |
| 32827163 | To evaluate ultrasound signs of coronavirus disease-19 (COVID-19) pneumonia in symptomatic healthcare professionals and to correlate those changes with clinical findings. […] All patients underwent real-time polymerase chain reaction (RT-PCR), lung ultrasound (LUS) and clinical evaluation on the same day. […] All participants had clinical symptoms, with cough in 84.1%, fever in 69.7%, and dyspnea in 36.2% of cases. | 2020-08-23 |
| 32827313 | A number of clinical studies are underway to investigate this possibility but even if they prove effective-many questions will remain. | 2020-08-23 |
| 32827360 | The most of infected patients have no symptoms of disease. | 2020-08-23 |
| 32827394 | Objectives Clinical laboratories plays a key role in screening, diagnosis and containment of the Coronavirus 2019 infection epidemic. | 2020-08-23 |
| 32827436 | In this multi-center cohort of hospitalized COVID-19 patients in the largest health system in Massachusetts, there was no association between race/ethnicity and clinically relevant hospitalization outcomes, including in-hospital mortality, after controlling for key demographic/clinical characteristics. | 2020-08-23 |
| 32827525 | Only 25 children (51%) with acute SARS-CoV-2 infection presented with fever; symptoms of SARS-CoV-2 infection, if present, were nonspecific. […] Nasopharyngeal viral load was highest in children in the first 2 days of symptoms, significantly higher than hospitalized adults with severe disease (P = .002). […] This study reveals that children may be a potential source of contagion in the SARS-CoV-2 pandemic despite having milder disease or a lack of symptoms; immune dysregulation is implicated in severe postinfectious MIS-C. | 2020-08-23 |
| 32827582 | However, the disease, which, like other respiratory pathogens that cause common cold symptoms is believed to be transmitted through respiratory droplets. […] Moreover, because the signs and symptoms of COVID-19 are easily misattributed to the sequelae of cancer itself, such as pulmonary embolism, or its treatment, such as nausea and diarrhea, diagnosis may be delayed or missed. […] This review summarizes the current understanding of the transmission, clinical presentation, diagnosis and differential diagnosis, pathogenesis, rationale to treat the cancer or not, treatment and prevention of COVID-19 with an emphasis on implications in cancer. | 2020-08-23 |
| 32827594 | Our study aimed to review the impact of COVID-19 pandemia in children and adolescents with type 1 diabetes mellitus, to analyze the clinical characteristics of the infection and to propose clinical practice recommendations from the Italian Society for Pediatric Endocrinology and Diabetology (ISPED). […] Clinical manifestations include mild, moderate, severe disease up to critical illness. | 2020-08-23 |
| 32827597 | Among SARS-CoV-2 positive patients, fever (n = 5, 50%) and cough (n = 4, 40%) were the most common symptoms. | 2020-08-23 |
| 32827627 | Thus, we conducted a network meta-analysis comparing the rate of clinical improvement among patients with COVID-19 who received 5-day course of remdesivir versus 10-day course of remdesivir versus standard care. […] Our network meta-analysis of 4 randomized controlled trials demonstrated that the rate of clinical improvement was significantly higher in the 5-day remdesivir group and 10-day remdesivir group compared to standard care group (OR [95% confidence interval [CI]] =1.89 [1.40-2.56], P <0.001, OR [95% CI] =1.38 [1.15-1.66], P <0.001, respectively). […] In addition, the rate of clinical improvement was significantly higher in the 5-day remdesivir group compared to the 10-day remdesivir group (OR [95% confidence interval [CI]] =1.37 [1.01-1.85], P =0.041). […] Our analysis demonstrated that the use of remdesivir for patients with COVID-19 was associated with the significantly higher clinical improvement rate compared with standard care alone. | 2020-08-23 |
| 32827672 | The population and spatial characteristics of COVID-19 infections are poorly understood, but there is increasing evidence that in addition to individual clinical factors, demographic, socioeconomic, and racial characteristics play an important role. | 2020-08-23 |
| 32827705 | Although most of the patients do not present symptoms or are mildly symptomatic, some people infected with SARS-CoV-2 that experience more severe multiorgan dysfunction. […] Also, SARS-CoV-2 can cause gastrointestinal symptoms, such as vomiting, diarrhea, or abdominal pain during the early phases of the disease. […] Thus, diagnosing gastrointestinal symptoms that precede respiratory problems during COVID-19 may be necessary for improved early detection and treatment. | 2020-08-23 |
| 32827715 | We describe epidemiological and clinical characteristics and aim at identifying risk factors for SARS-CoV-2 detection during the first 6 weeks of operation. […] Austria, OR 4.16; 95% CI 2.48-6.99), recent onset of symptoms (second week, OR 3.61; 95% CI 1.87-6.98) and an impaired sense of smell/taste (4.08; 95% CI 2.36-7.03). […] In this young population, early-onset presentation of COVID-19 resembled flu-like symptoms, except for smell and/or taste dysfunction. […] Risk factors for SARS-CoV-2 detection were return from regions with high incidence and contact with confirmed SARS-CoV-2 cases, particularly when tests were administered within the first 2 weeks after contact and/or onset of symptoms. | 2020-08-23 |
| 32827748 | Social distancing, cancellation of elective cases, and staff re-deployment have compromised clinical and academic teaching. | 2020-08-23 |
| 32827801 | A multi-center cross-sectional survey on depressive symptoms, anxiety symptoms, and abuse was conducted. […] The Hospital Anxiety and Depression Scale (HADS) was used to measure the prevalence of anxiety and depressive symptoms among healthcare workers. […] Depressive and anxiety symptoms were compared to the basic characteristics of the participants to determine the association. […] A total of 420 (56.3%) participants had depressive symptoms, while 348 (46.7%) had anxiety symptoms. […] Age, residency status, department, stigmatization, and living in a conflict zone were significantly associated with depressive symptoms. […] Age, department, years of experience, working hours per week, internal displacement, stigmatization, living in a conflict zone, and verbal abuse were significantly associated with anxiety symptoms. […] Our study presents important findings regarding depressive, anxiety symptoms, and abuse among physicians providing care during the COVID-19 outbreak and civil war in Libya. […] It also demonstrates several factors that can be associated with depressive and anxiety symptoms in this population. | 2020-08-23 |
| 32827898 | A total of 122 subjects with COVID-19 were included: 106 SARS-COV-2 RT-PCR-positive patients and 16 RT-PCR-negative patients with symptoms and chest computed tomography (CT) consistent with COVID-19. […] Demographic and clinical characteristics were retrieved from electronic records. […] The most frequent comorbidities were hypertension and diabetes mellitus and the most frequent symptoms were fever, cough, and dyspnea. | 2020-08-23 |
| 32827932 | Herein, we aimed to clarify the epidemiological and clinical characteristics of patients presenting with diarrhea. […] Clinicians are required to promptly identify the patients with initial diarrhea symptoms and pay adequate attention to the nutrient requirements of the patients with diarrhea during hospitalization. | 2020-08-23 |
| 32827969 | In order to describe the outcome of COVID-19 in multi-centre a cohort of PD patients and explore its potential predictors, we gathered the clinical information of 117 community-dwelling patients with COVID-19 followed in 21 tertiary centres in Italy, Iran, Spain, and the UK. | 2020-08-23 |
| 32828137 | As the global COVID-19 pandemic continues, unabated and clinical trials demonstrate limited effective pharmaceutical interventions, there is a pressing need to accelerate treatment evaluations. […] Antiviral combination selection can be facilitated by insights regarding SARS-CoV-2 pathophysiology and cell cycle dynamics, supported by infectious disease and clinical pharmacology expert advice. […] We describe a clinical evaluation strategy using adaptive combination platform trials to rapidly test combination therapies to treat COVID-19. | 2020-08-24 |
| 32828189 | These disparities are noted in epidemiology, pathophysiology, clinical manifestations, disease progression, and response to treatment. | 2020-08-24 |
| 32828312 | In the process of fighting against the epidemic in China, the clinical value of a variety of herbal medicines has been recognized and written into the clinical application guide. | 2020-08-24 |
| 32828569 | Delirium is frequently found in patients who test positive for COVID-19, even in the absence of respiratory symptoms. […] COVID-19 is associated with neuropsychiatric symptoms. | 2020-08-24 |
| 32828595 | A variety of cutaneous symptoms have presented throughout various stages of the disease (Marzano, 2020; Recalcati, n.d. […] The patient described tested positive for COVID-19 three days prior to presentation for the rash with minimal other symptoms of COVID-19. | 2020-08-24 |
| 32828694 | Few data are available about the risk of COVID-19 infection in persons with hematological cancer, but controversy whether these persons have the same clinical signs and outcomes. | 2020-08-24 |
| 32828701 | After the peak of the epidemy, we measured anti-SARS-CoV-2 IgM and IgG antibodies in 149 patients and collected clinical data. […] Even if respiratory symptoms linked to CF are frequent and compatible with COVID-19, anti-SARS-CoV-2 IgG antibodies were detected only in 3 asymptomatic patients. […] This reassuring study concerning the risk of COVID-19 in patients with CF illustrates the difficulty to distinguish COVID-19 symptoms from respiratory exacerbations and the need of generalized molecular testing to make a precise diagnosis. | 2020-08-24 |
| 32828735 | Clinical prediction scores support the assessment of patients in the emergency setting to determine the need for further diagnostic and therapeutic steps. […] Based on our clinical experiences in dealing with COVID-19 patients at the University Hospital in Zurich, we created a triage score with the acronym “AIFELL” consisting of clinical, radiological and laboratory findings. […] The results suggest that the AIFELL score has potential as a triage tool in the ER setting intended to select probable COVID-19 cases for hospitalization in spontaneously presenting or referred patients with acute respiratory symptoms. | 2020-08-24 |
| 32828741 | Accordingly, a wider clinical trial has been designed. | 2020-08-24 |
| 32828791 | In addition to analysis of CCP, analysis of SARS-CoV-2 IgG provides information for possible past exposure and may support diagnosis when SARS-CoV-2 PCR is negative and clinical suspicion for COVID-19 is high. […] Given the heterogeneity among methods for, and antigenic targets used in SARS-CoV-2 antibody assays, it is necessary for careful evaluation of these assays prior to implementation for clinical use. | 2020-08-24 |
| 32829043 | When considering household members, all 12 patients who tested negative and who did not develop any relevant clinical symptoms compatible with COVID-19 were 1 - 16 years of age. […] The clinical attack rate (symptoms compatible with COVID-19 and biologically confirmed by PCR) in adults was 85% compared to 26% in children. | 2020-08-24 |
| 32829047 | In much of the discourse about COVID-19 lung disease, the more familiar clinical entity of acute respiratory distress syndrome (ARDS) has been used as the guiding paradigm. | 2020-08-24 |
| 32829051 | We explored the effect of antiretroviral treatment (ART) history on clinical characteristics of patients with SARS-CoV-2 and HIV co-infection. […] Most patients with SARS-CoV-2 and HIV co-infection exhibited mild to moderate symptoms. | 2020-08-24 |
| 32829073 | Pooled prevalence rate of psychological morbidities includes poor sleep quality (40%), stress (34%), psychological distress (34%), insomnia (30%), post-traumatic stress symptoms (27%), anxiety (26%), depression (26%). | 2020-08-24 |
| 32829312 | Afterwards, for many years, the clinical application of serum LDH measurement has been limited to the evaluation of anemias and to as a rough prognostic tool for certain tumors. […] Conclusions This increased clinical role calls for an improvement of LDH assay standardization through the implementation of traceability of results of clinical samples to the available reference measurement system. | 2020-08-24 |
| 32829390 | Its clinical efficacy in patients with COVID-19 under mechanical ventilation remains to be evaluated. […] Clinical characteristics and outcome of patients treated with remdesivir were collected retrospectively and compared with those of patients hospitalized in the same time period. | 2020-08-24 |
| 32829464 | According to the data delivered from 185 oncology nurses, 57.7% of the participants had an undergraduate degree, 74.1% were working in adult oncology units, and 52.4% of them were working as clinical nurses, 48.1% of the nurses received education for COVID-19 (51.9% did not receive) and 70.3% followed and read the COVID-19 Guidelines published by the Ministry of Health (29.7% did not follow guidelines). | 2020-08-24 |
| 32829467 | Clinical evolution in the blood was marked by an increase (2-3-fold) in differentiated effector T cells expressing exhaustion (PD-1) and senescence (CD57) markers, an expansion of antibody-secreting cells, a 15-fold increase in γδ T cell and proliferating NK-cell populations, and the total disappearance of monocytes, suggesting lung trafficking. […] The investigation was conducted as part of an overall French clinical cohort assessing patients with COVID-19 and registered in clinicaltrials.gov under the following number: NCT04262921. | 2020-08-24 |
| 32829601 | Conclusions: Large-scale, standardized clinical testing platform, with nucleic acid testing, high-throughput sequencing, and immunoprotein assessment capabilities, need to be implemented simultaneously in order to maximize the effect of quarantine and minimize the duration and cost of the quarantine. | 2020-08-25 |
| 32829607 | The paper aims to provide reference for the prevention and nursing of device related pressure ulcers and related skin diseases for clinical medical staff, especially to the respectable personnel in front line of fighting against coronavirus disease 2019. | 2020-08-25 |
| 32829718 | Whilst for most, their anxiety will be proportionate to the threat, for some, existing pre-occupation with physical symptoms and illness will become more problematic. | 2020-08-25 |
| 32829745 | We will include adults (>18 years of age) without prior confirmed COVID-19 or symptoms suggestive of COVID-19, who spend more than three hours per day outside the home with exposure to other people. | 2020-08-25 |
| 32829859 | It is strongly supported for that PF should be one of the major complications in COVID-19 patients by the evidences of epidemiology, viral immunology and current clinical researches. | 2020-08-25 |
| 32829885 | In the present authors’ experience, from five different hospitals in Italy and the UK, imaging has proved its utility in identifying these COVID-19-related thrombotic complications, with translational clinical relevance. | 2020-08-25 |
| 32830154 | To initiate case management, COVID-19 should be suspected based on patient symptoms and/or high-risk history and then should be confirmed by viral testing, such as reverse transcription polymerase chain reaction (RT-PCR) analysis. […] Quarantine following contact tracking with risk stratification is effective in preventing transmission, and the essentials of medical surveillance include monitoring different types of symptoms, delegation of supervision, and continuation of surveillance regardless of the RT-PCR results. | 2020-08-25 |
| 32830267 | Our aim was to analyze the incidence, clinical presentation, and severity of SARS-CoV-2 infection in patients with IBD. […] Data were obtained by patient electronical medical records and by phone interview. […] Digestive symptoms were reported in 41 patients (50.0%), with diarrhea as the most common (42.7%). […] In the multivariate analysis, the presence of dyspnea was associated with moderate to severe infection (odds ratio, 5.3; 95% CI, 1.6-17.7; P = 0.01) and myalgias (odds ratio, 4.8; 95% CI, 1.3-17.9; P = 0.02) were related to a milder clinical course. | 2020-08-25 |
| 32830284 | The C19-YRS telephone screening tool, developed previously, was used to screen symptoms and grade their severity. | 2020-08-25 |
| 32830527 | The coronavirus disease 2019 (COVID-19) pandemic, originating from Wuhan, China, is known to cause severe acute respiratory symptoms. […] Intravenous injection of clinical-grade MSCs into COVID-19 patients can induce an immunomodulatory response along with improved lung function. […] Dental pulp stem cells (DPSCs) are considered a potential source of MSCs for immunomodulation, tissue regeneration, and clinical application. […] Although some current clinical trials have treated COVID-19 patients with DPSCs, this therapy has not been approved. | 2020-08-25 |
| 32830577 | A 46% pooled prevalence of anxiety symptoms (95% CI 33.9-58.2%) was found with significant evidence of between-study heterogeneity (Q = 154953, I2 = 99.99%, p < 0.001). […] Age and sex were not found to be significant moderators for anxiety symptoms. […] Intervention programs for anxiety symptoms are highly recommended. | 2020-08-25 |
| 32830949 | Although respiratory symptoms are a key feature of the disease, many people who are hospitalized with COVID-19 also suffer acute kidney injury, a condition that exacerbates patient mortality and may have to be treated through renal replacement therapy. | 2020-08-25 |
| 32831083 | The COSUP clinical team prioritised opioid substitution therapy using methadone and COVID-19 screening over generalist healthcare to manage withdrawal and contain tension and anxiety. | 2020-08-25 |
| 32831151 | This study is a multicenter, randomized, controlled, open-label, two-arm ratio 1:1, parallel group clinical trial. […] Chinese Clinical Trial Registry: ChiCTR2000030043. | 2020-08-25 |
| 32831155 | Systematic searching of clinicaltrials.gov , EudraCT, the WHO ISRCTN registry, and the Chinese clinical trials registry. | 2020-08-25 |
| 32831186 | Using Google Trends, queries for chest pain that have previously been shown to closely correlate with coronary heart disease were compared with searches for myocardial infarction and COVID-19 symptoms. […] The current study evaluates if search terms (or topics) pertaining to chest pain symptoms correlate with the reported decrease in presentations of ACS. […] Searches on COVID-19 symptoms (eg, cough, fever) rose initially but returned to baseline while chest pain-related searches remained elevated throughout May. | 2020-08-25 |
| 32831319 | Given that some reports suggest that this infection can also occur with neurologic manifestations, this narrative review addresses the basic and clinical aspects concerning the nervous system involvement associated with this disease. […] Since maybe not all COVID-19 neurological manifestations are due to SARS-CoV-2 direct effects, it is important to monitor the rest of the clinical parameters such as, for example, oxygen saturation. | 2020-08-25 |
| 32831341 | To determine the levels of anxiety, depression and self-care symptoms during the COVID-19 pandemic in the general population. […] Out of 1508 included participants, 20.8% had symptoms of severe anxiety, while 27.5% showed symptoms of severe depression. […] Being a woman, being single, having no children, having medical comorbidities and a history of mental health care were risk factors for developing symptoms of anxiety and depression; 66 to 80 % of the population complied with self-care recommendations. […] A larger number of individuals with moderate to severe anxiety and depression symptoms were observed than in other pandemics. | 2020-08-25 |
| 32831342 | Clinical monitoring at the hospital and social health centers showed that patient profile was like that documented in the literature and that the incidence of COVID-19 was low in social health centers. | 2020-08-25 |
| 32831521 | To be clear, the natural history of SARS-CoV2 infection and of the patho-physiology of CoViD-19 remains shrouded in relative confusion, in part due to the exceedingly virulent nature of the virus, as manifest by its elevated morbidity and mortality, and the fast accumulation of clinical observations and research evidence. | 2020-08-25 |
| 32831935 | Because coronavirus disease 2019 (COVID-19) is relatively new, health-care organizations and researchers have been publishing guidelines and recommendations to help health-care providers proceed safely with various aspects of disease management and investigation. […] Most of the published papers have addressed clinical presentation, diagnostic tests, mitigation measures, and hospital preparedness. | 2020-08-25 |
| 32831936 | Demographic, clinical, and laboratory data were collected. […] No clinical correlation (r) could be appreciated between the duration of test positivity and age of afflicted COVID-19 patients (r = -0.0976). […] The present evaluation of various facets of the ongoing global pandemic of COVID-19 is an attempt to portray early clinical and epidemiological parameters of the menace of COVID-19 patients admitted at SMS Medical College and Attached Hospitals, Jaipur. | 2020-08-25 |
| 32831937 | This retrospective study involved patients from five centers, who were admitted with typical COVID-19 symptoms and found to be positive for COVID-19 real-time reverse transcription-polymerase chain reaction (rtRT-PCR) test. […] Chest CT imaging is a quite valuable tool in patients with longer than 2 days’ duration of symptoms, in whom clinical and epidemiological data support the diagnosis of COVID-19 infection. | 2020-08-25 |
| 32832425 | Other ethical issues, such as that related to conducting clinical trials during the pandemic, and the increase in domestic violence during the quarantine period, will be also discussed. | 2020-08-25 |
| 32832594 | In this report, we present a case of an octogenarian woman with breast cancer who was treated initially with radical mastectomy and chemotherapy, who then developed back pain in mid-March 2020, that later progressed to bilateral lower extremity weakness secondary to cord compression, which was diagnosed nearly 4 weeks after her initial symptoms started. | 2020-08-25 |
| 32832666 | More than 1050 clinical trials are registered at FDA.gov that explore multipotent mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable, including neurodegenerative and cardiac disorders, perianal fistulas, graft-versus-host disease, COVID-19, and cancer. […] However, most of the clinical-stage MSC therapies have been unable to meet primary efficacy end points. […] The innate therapeutic functions of MSCs administered to humans are not as robust as demonstrated in preclinical studies, and in general, the translation of cell-based therapy is impaired by a myriad of steps that introduce heterogeneity. […] In this review, we discuss the major clinical challenges with MSC therapies, the details of these challenges, and the potential bioengineering approaches that leverage the unique biology of MSCs to overcome the challenges and achieve more potent and versatile therapies. | 2020-08-25 |
| 32832721 | COVID-19, a disease caused by a novel coronavirus, SARS-CoV-2, has reached the proportion of a pandemic and presents with either mild and moderate symptoms or in severe cases with acute respiratory distress syndrome, multiple organ dysfunction syndrome and even death. | 2020-08-25 |
| 32832740 | We built a clinical decision support tool on the avoMD platform that systematizes and personalizes the treatment of COVID-19 by bringing point-of-care access to the guidelines specific to individual cases to the clinician’s hands. | 2020-08-25 |
| 32832851 | It is proposed to publish the findings of this rapid review along with a summary of an institutional REC response to the challenges of reviewing and approving clinical research proposals in the time of a pandemic. | 2020-08-26 |
| 32832913 | Relevant and up-to-date literature, media reports, and author experiences were included from Medline, national newspapers, and public clinical trial databases. […] Ongoing clinical trials will determine the efficacy and safety of anti-cytokine therapies in coronavirus disease 2019. | 2020-08-25 |
| 32832914 | Participants were examined at the time of enrollment in an ongoing clinical trial (NCT04306393), and no patients were excluded from echocardiographic analysis. | 2020-08-25 |
| 32832926 | The risks of COVID-19 transmission and potential increased surgical morbidity must be weighed up against the patient’s ongoing symptoms and quality of life. | 2020-08-25 |
| 32833241 | The clinical presentation of COVID-19 ranges from that of being asymptomatic to developing a fatal illness characterized by multiple organ involvement. | 2020-08-25 |
| 32833258 | With these important advantages, LUVs could be more powerful than other vaccines for controlling some viral diseases, and they warrant urgent investigation with animal experiments and clinical trials for defeating the COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2. | 2020-08-25 |
| 32833259 | Together, these data reveal marked perturbations of factor V activity in severe COVID-19, provide links to SARS-CoV-2 disease biology and clinical outcomes, and nominate a candidate biomarker to investigate for guiding anticoagulation therapy in COVID-19. | 2020-08-25 |
| 32833273 | Four domains of telemedicine were assessed: legal regulations, reimbursement, clinical use, and barriers; comparing emerging responses to the pandemic versus the baseline scenario. | 2020-08-25 |
| 32833297 | The primary outcome variable was time from onset of symptoms to ED presentation. | 2020-08-25 |
| 32833382 | Three major themes were identified relating to the impact of COVID-19 on physicians: (1) changes to direct patient care, (2) changes to nonclinical aspects of physician’s practices, and (3) impacts on personal and family well-being. | 2020-08-25 |
| 32833384 | However, physical distancing requirements during a global pandemic have resulted in cancellation and/or postponement of “in-person” educational sessions, ultrasound conferences, and clinical diagnostic and interventional ultrasound cases that enhance ultrasound training. | 2020-08-25 |
| 32833506 | A diverse, global network made up of laboratory scientists, clinical researchers, epidemiologists, data science teams, physicians, and so on must have a standardized, collaborative, virtual biobanking solution to share clinical expertise and evidence-based solutions. […] It is essential for biobanks to collect COVID-19 specimens along with corresponding clinical and demographic data from COVID-19 diagnostic testing. […] Data entered into LIMS will be beneficial in designing much needed clinical trials to address any unmet needs to better address clinical treatment and outcomes. […] The partners or entities associated with the COVID-19 data sharing network will be able to effectively communicate, view data, and images associated with their respective research interest to advance COVID-19 research and data driven, clinical care. | 2020-08-25 |
| 32833568 | These patients have varying death experiences based on their location of death, the availability and utilization of various medical technologies, the amount of strain on the local health care system, the involvement of specialist palliative care (PC) teams, and access to essential medications to alleviate symptoms at the end of life. | 2020-08-25 |
| 32833573 | There are an increasing number of clinical studies for COVID-19, with several large cohort studies documenting initial signs and symptoms. […] Realizing the need for current information, this summary provides a focused summary of pertinent clinical diagnostic information about neurological involvement of SARS-CoV-2 virus and clinical presentation of COVID-19, especially in relationship to patients with seizures and epilepsy. | 2020-08-25 |
| 32833660 | Telemonitoring offers the opportunity to carefully monitor patients with a confirmed or suspected case of COVID-19 from home and allows for the timely identification of worsening symptoms. […] In this paper, we present a COVID-19 telemonitoring care pathway developed at a tertiary care hospital in the Netherlands, which combined the monitoring of vital parameters with video consultations for adequate clinical assessment. | 2020-08-25 |
| 32833671 | In this study, we assessed the clinical course and features of COVID-19 patients. […] Seventy-two (66.1%) patients aged over 60; these patients were more likely to develop respiratory symptoms. […] We found significant differences in age, respiratory symptoms, and heart rates between patients with and without underlying conditions. | 2020-08-25 |
| 32833770 | Here we describe the epidemiology, pathophysiology, transmission, and symptoms of the virus. | 2020-08-25 |
| 32833772 | Supportive care remains the mainstay of therapy while ongoing clinical trials are being conducted. | 2020-08-25 |
| 32833773 | Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can vary from asymptomatic to severe symptoms. | 2020-08-25 |
| 32833774 | We discuss the basis of cardiac pathophysiology and address some of the clinical scenarios that cardiovascular physicians may face. | 2020-08-25 |
| 32833954 | CONCLUSIONS The temporal relationship between clinical presentation of acute pancreatitis and SARS-CoV-2 infection in this patient with no precipitating risk factors for pancreatitis suggests COVID-19-associated acute pancreatitis. | 2020-08-25 |
| 32834113 | It is recommended that telaprevir, and pyridone-containing pharmaceuticals including aminoglutethimide, apixaban, buspirone, lenalidomide, and pomalidomide be repurposed for COVID-19 treatment after suitable validation and clinical trials. | 2020-08-25 |
| 32834194 | It causes Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and presents a broad spectrum of clinical manifestations, ranging from entirely asymptomatic through severe acute respiratory failure and death. | 2020-08-25 |
| 32834253 | The presence of a large number of infected individuals with few or no symptoms is an important epidemiological difficulty and the main mathematical feature of COVID-19. […] The A-SIR model, i.e. a SIR (Susceptible-Infected-Removed) model with a compartment for infected individuals with no symptoms or few symptoms was proposed by Gaeta (2020). | 2020-08-25 |
| 32834272 | The present study aims to examine the comorbidity patterns of the symptoms (intrusion and avoidance) for posttraumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) and the role of perceived threat and courtesy stigma in distinguishing specific patterns of the symptoms for PTSD and GAD among children and adolescents who are susceptible to coronavirus disease 2019 (COVID-19) in Hubei, China. […] The Latent Profile Analysis identified the three profiles of the symptoms for PTSD and GAD which were labeled as Moderate PTSD, Mild Comorbidity, and Severe Comorbidity. […] The scores of the symptoms for PTSD, GAD, perceived threat, and stigma were different among the three profiles. | 2020-08-25 |
| 32834276 | Kessler psychological distress scale (K10) was used to evaluate stress symptoms. | 2020-08-25 |
| 32834295 | Common symptoms of COVID-19 illness included fever, cough, and abnormal findings on chest computed tomography. | 2020-08-25 |
| 32834302 | The influence of music therapy (MT) as a support intervention to reduce stress and improve wellbeing in Clinical Staff (CS) working with COVID-19 patients was evaluated. | 2020-08-25 |
| 32834311 | Six antimicrobial-resistant clinical and two susceptible control strains of Pseudomonas aeruginosa and Staphylococcus aureus species were analyzed. | 2020-08-25 |
| 32834314 | Acknowledging strange symptoms of coronavirus is vital to curbing its spread. | 2020-08-25 |
| 32834322 | Contrary to medical expectation, many people with covid-19 are still experiencing symptoms weeks or even months later. | 2020-08-25 |
| 32834468 | Yet official data may underestimate the actual cases due to limited symptoms and testing capacity. | 2020-08-25 |
| 32834523 | Likewise, deep learning applications (DL) on pulmonary medical images emerged to achieve remarkable advances leading to promising clinical trials. | 2020-08-25 |
| 32834527 | A systematic review was conducted regarding clinical studies on cases that had neurological manifestations associated with COVID-19 and other coronaviruses. […] The search was carried out in the electronic databases PubMed, Scopus, Embase, and LILACS with the following keywords: “coronavirus” or “Sars-CoV-2” or “COVID-19” and “neurologic manifestations” or “neurological symptoms” or “meningitis” or “encephalitis” or “encephalopathy,” following the Systematic Reviews and Meta-Analyses (PRISMA) guidelines. […] The Investigation included 409 patients diagnosed with CoV infection who presented neurological symptoms, with median age range varying from 3 to 62 years. | 2020-08-25 |
| 32834556 | This can be done by analyzing patient characteristics, case trajectory, comorbidities, symptoms, diagnosis, and outcomes. […] Features examined included details of the individuals concerned, e.g., age, gender, observation of fever, history of travel, and clinical details such as the severity of cough and incidence of lung infection. […] Statistical analyses revealed that the most frequent and significant predictive symptoms are fever (41.1%), cough (30.3%), lung infection (13.1%) and runny nose (8.43%). […] While 54.4% of people examined did not develop any symptoms that could be used for diagnosis, our work indicates that for the remainder, our predictive model could significantly improve the prediction of COVID-19 status, including at early stages of infection. | 2020-08-25 |
| 32834589 | During the transmission of COVID-19, the hospital isolation of patients with mild symptoms has been a concern. […] As long as possible, high-intensity isolation measures should be taken in time for patients with mild symptoms. | 2020-08-25 |
| 32834623 | We also statistically enhance the robustness behind the discharge/recovery clinical criteria in the absence of a direct test, which is typically the case of non-first world countries, where the limited testing capabilities are fully dedicated to the evaluation of new cases. | 2020-08-25 |
| 32834649 | Our model incorporates the asymptomatic infected individuals, who represent the majority of the infected population (with symptoms or not) and could play an important role in spreading the virus without any knowledge. | 2020-08-25 |
| 32834657 | Due to the dynamics of COVID-19 where many infected people are not showing symptoms or showing mild symptoms, and where different countries are employing different testing strategies, it is quite difficult to calculate the R, while the pandemic is still widespread. […] The results suggest that with a reasonable estimate of distribution of delay to death from the onset of symptoms, the model can provide accurate estimates of R. | 2020-08-25 |
| 32834711 | In this review, we aimed to contribute with a review of the literature, sharing our clinical experience supported by actigraphic evaluation and by proposing future strategies. […] Sleep disorders, in particular insomnia, have been commonly reported in frontline medical workers, in hospitals during the COVID-19 pandemic and are often accompanied by depressive and anxiety symptoms. […] Sleep quality, however, has been mainly assessed by the use of self-reported measures, thus limiting clinical usefulness. | 2020-08-25 |
| 32834718 | During the virtual visits, we discussed the clinical progress of patients, wound status, treatment modification, the time of return to work, postoperative complications, and the radiological data of the patients. | 2020-08-25 |
| 32834831 | An experiment was conducted to test these eight algorithms on a real COVID-19 symptom dataset, after selecting the relevant symptoms. | 2020-08-25 |
| 32834833 | The aim of the present study was to investigate the cross-sectional association between physical activity levels with depressive symptoms, anxiety symptoms, and positive mental well-being in a sample of the UK public social distancing owing to COVID-19. […] Participants also reported on sociodemographic and clinical data. […] Similar findings were obtained for moderate-to-severe anxiety symptoms, moderate-to-severe depressive symptoms and poor mental wellbeing. | 2020-08-25 |
| 32834891 | Coronavirus disease of 2019 (COVID-19), which originated in China in 2019, shows mild cold and pneumonia symptoms that can occasionally worsen and result in deaths. | 2020-08-25 |
| 32834893 | Additionally, therapeutic strategies employed in HAE should be considered for the treatment of COVID-19, and clinical trials should be performed. | 2020-08-25 |
| 32834899 | Randomized clinical trials are not relevant for infectious disease outbreaks due to a new pathogen, for which public health decisions have to be made urgently. | 2020-08-25 |
| 32834902 | Typical symptoms include fever, dry cough and shortness of breath. […] Gastrointestinal symptoms such as nausea, vomiting, abdominal pain and diarrhoea have been reported; neurologically related symptoms, particularly anosmia, hyposmia and dysgeusia, have also been reported. | 2020-08-25 |
| 32834903 | We report the case of a child with asthma who sought care for COVID-19 symptoms whose condition did not improve despite appropriate treatment for asthma, pneumonia and COVID-19. | 2020-08-25 |
| 32834922 | Many clinical trials are now being conducted to test possible therapies. […] Therefore, brincidofovir is worth further investigations and clinical trials as a possible therapeutic agent for the COVID-19 disease caused by the novel SARS-CoV-2. | 2020-08-25 |
| 32834926 | We examine disparities in clinical data for US patients by developing correlation and imputation methods for data completeness. […] The data lifecycle followed is methodical and deliberate; 1000+ clinical, demographical, and laboratory variables are collected from the Centers for Disease Control and Prevention (CDC). | 2020-08-25 |
| 32834943 | The current paper concludes with some clinical recommendations on how to treat obsessional fears of contamination in the context of the current pandemic. | 2020-08-25 |
| 32834946 | Current findings have shown that the Chinese medicine can reduce the incidence of severe or critical events, improve clinical recovery and help alleviate symptoms such as cough or fever. […] To date there are over 133 ongoing registered clinical studies on TCM/integrated traditional Chinese and Western medicine. | 2020-08-25 |
| 32834950 | Several dosing regimens were proposed based on PBPK simulation combined with known clinical exposure-response relationships. […] The model was also validated by clinical data from Chinese patients with COVID-19. | 2020-08-25 |
| 32834981 | Sars-CoV2 is a novel coronavirus that is transmitted to humans through zoonosis and characterised by mild to moderate pneumonia-like symptoms. | 2020-08-25 |
| 32834988 | Cardiac ultrasound, electrocardiogram and clinical findings suggested a diagnosis of cardiogenic obstructive shock due to acute pulmonary embolism, successfully treated with thrombolysis. | 2020-08-25 |
| 32834989 | Scarce data exist regarding the clinical sequelae of COVID-19 and/or the prevalence of thromboembolic disease in asymptomatic patients. […] Herein, we present the clinical story of insidious PE development in two asymptomatic COVID-19 female patients. […] Issues regarding the pathogenesis of thromboembolism in COVID-19 and the clinical management are equally discussed. | 2020-08-25 |
| 32835001 | This review commences with the recent develop biosensor for Covid-19 detection and listing down the available biomarkers with their secretion range comparison of normal to COVID-19 patients through clinical analysis in china and concludes with the future approach for the diagnosis. | 2020-08-25 |
| 32835004 | During novel coronavirus 2019 (COVID-19) pandemic, patients usually present with several reports showing symptoms of severe systemic or respiratory illness and, although rare, some genital complaints such as scrotal discomfort can be seen. […] In the majority of patients, however, genital complaints seem not to be the initial or sole symptoms. […] In this article, we report an unusual presentation of a male case with severe external genital pain which was suspected to be the first clinical sign of COVID-19. | 2020-08-25 |
| 32835017 | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) usually causes fever, respiratory symptoms, malaise and myalgia. […] We report a case of a 29-year-old male with -on nasopharyngeal testing- confirmed SARS-CoV-2 infection with severe respiratory symptoms, followed by clinical and radiological signs of encephalitis. | 2020-08-25 |
| 32835018 | The present short report summarizes some clinical characteristics of six patients affected by stroke while being on angiotensin-converting enzyme (ACE)2 inhibitors and angiotensin II receptor blockers (ARBs) before and during COVID-19. […] All patients showed clinical features typical of SARS-CoV-2 infection and positive chest CT scan, and were treated with ACE-Is as needed. […] Whether or not and in which manner the pharmacomodulation of the renin-angiotensin system may had affect the clinical course of the reported six COVID-19 patients affected by stroke has to be still clarified. […] An urgent need of randomized clinical trials aimed to assess the safety profile and neuroprotective properties of ACE-Is and ARBs in COVID-19 patients diagnosed with stroke does exists. | 2020-08-25 |
| 32835020 | Postoperatively, the patient is in good condition, with the Glasgow Coma Scale (GCS) score of 15, with mild, left hemiparesis, 4+/5 points on the Lovett scale, without symptoms of acute respiratory distress syndrome (ARDS). | 2020-08-25 |
| 32835021 | The patient is a 48-year-old SARS-COV-2 positive male with multiple comorbidities, who presented with fevers and respiratory symptoms, and imaging consistent with multifocal pneumonia. | 2020-08-25 |
| 32835023 | The spectrum of symptoms of COVID-19 continues to expand as more clinical observations are reported. […] We describe a patient in Tanzania who experienced severe headache for seven days before the onset of other symptoms of COVID-19 that led to her isolation, diagnosis, and treatment. | 2020-08-25 |
| 32835037 | All of the affected anesthesiologists had symptoms 2-12 days after the intubation encounter (average 6 ± 3 days). […] All had radiological image evidence of bilateral pneumonia and all reported relatively mild symptoms. […] The affected doctors were out of clinical service for 20-60 days (average 46 ± 12 days). […] One of these nurses was in critical condition but was eventually discharged with a loss of 50 days of clinical service. […] The remaining three nurses have had mild symptoms so far, but one is still hospitalized. | 2020-08-25 |
| 32835062 | In addition, in a pandemic context, the limits between the government’s, practitioner’s and patient’s rights and obligations are not clear which could significantly endanger the universal ethical principles in clinical practice. […] It could also undermine any attempt to develop serious clinical trials to prove the considered off-label drug. | 2020-08-25 |
| 32835066 | This study aims to identify the characteristics of patients in whom imaging progression occurred while clinical symptoms were relieved and to guide radiological reexamination. […] We divided patients into two groups according to the matching degree between clinical and imaging outcomes. 21 patients displayed imaging progression while symptoms relieved. | 2020-08-25 |
| 32835072 | It is now well known that COVID-19 cases may result in mild symptoms leading to patient recovery. | 2020-08-25 |
| 32835073 | Firstly, a literature survey is done on COVID-19 highlighting a number of factors including its origin, its similarity with previous coronaviruses, its transmission capacity, its symptoms, etc. | 2020-08-25 |
| 32835080 | The study found that the proposed model can support physicians to easily diagnose suspected cases of COVID-19 based on their medical records without subjecting the specimen to laboratory tests. | 2020-08-25 |
| 32835082 | Moreover, the symptoms of novel coronavirus are quite similar to the general seasonal flu. | 2020-08-25 |
| 32835083 | According to the result, clinical assessment of these three herbal compounds and hsa-miR-1307-3p may have significant outcomes for the prevention, control, and treatment of COVID-19 infection. | 2020-08-25 |
| 32835086 | The study included 30 Covid-19 patients using l-Glutamine and 30 Covid-19 patients who did not use l-Glutamine with similar age, gender and clinical status. […] Diagnostic tests, laboratory examinations, clinical findings and computed thorax tomography imaging of the patients were evaluated. | 2020-08-25 |
| 32835089 | The antiviral drugs and their clinical advances, along with herbal medicines for viral inhibition and immunity boosters, are described. | 2020-08-25 |
| 32835090 | The in vitro activity of selected inhibitors can be done easily which will provide useful information for clinical treatment of novel coronavirus pneumonia. | 2020-08-25 |
| 32835113 | Most (90·5%) presented within the first week of symptoms, with a median time of symptoms prior to expiration being 8·42 days (IQR 5·57-12·72). | 2020-08-25 |
| 32835119 | Work in the Clinic for Neurology of the Clinical Center of Montenegro (CN-CCM) with MS patients continued as much as possible during the epidemic. | 2020-08-25 |
| 32835128 | The management of the tightly controlled environment of clinical research becomes a challenge, and the Food and Drug Administration set of priority recommendations for patient safety while maintaining study integrity. | 2020-08-25 |
| 32835131 | She was initiated on corticosteroid eye drops and her ocular symptoms resolved three days later. […] The association between toxic shock syndrome and COVID-19 is unclear; however, patients should be vigilant for symptoms as toxic shock syndrome can progress rapidly and cause multi-organ failure. | 2020-08-25 |
| 32835141 | Future work is necessary to further develop and test the system to make it acceptable for deployment outside of emergencies such as with COVID-19 pandemic in clinical environments, however, the nature of the design is such that desired features are relatively easy to add using protocols and parametric design files provided. | 2020-08-25 |
| 32835147 | The case fatality ratio (CFR) is one of the key measurements to evaluate the clinical severity of infectious diseases. | 2020-08-25 |
| 32835155 | Owing to nanotechnology-enabled advancements in sensing unit fabrication, device integration, interfacing, packaging, and sensing performance at point-of-care (POC) has rendered diagnostics according to the requirements of disease management and patient disease profile i.e. in a personalized manner. | 2020-08-25 |
| 32835165 | The most common symptoms include fever and respiratory tract symptoms. […] Nevertheless, some patients show less common symptoms such as gastrointestinal or neurological manifestations. […] This article presents the case of a 65-years old man who was presumptively infected with SARS-CoV-2 during his ski vacation in Austria in March 2020 and acutely presented with typical symptoms of Guillain-Barré syndrome. | 2020-08-25 |
| 32835190 | In addition, many studies have been published focusing on how COVID-19 may affect the liver and how pre-existing liver diseases might influence the clinical course of COVID-19. | 2020-08-25 |
| 32835210 | This study aimed to determine the clinical characteristics of patients diagnosed with the coronavirus disease 2019 (COVID-19). […] Clinical data of COVID-19 patients diagnosed between January 28, 2020 and February 23, 2020 at the Beijing You’an Hospital were summarized and analyzed. […] The first symptoms appeared at the onset of illness onset include fever in 36 patients (80%), cough in 23 patients (51%), and expectoration in 15 patients (33%), respectively. | 2020-08-25 |
| 32835211 | There are yet no experimental proof of any such association and the world health organisation (WHO) is currently testing the theory with clinical trials on selected cohorts. | 2020-08-25 |
| 32835245 | We aimed to assess the off-label use of anakinra in patients who were admitted to hospital for severe forms of COVID-19 with symptoms indicative of worsening respiratory function. | 2020-08-25 |
| 32835247 | The immune mechanism underlying diffuse alveolar and pulmonary interstitial inflammation in COVID-19 involves a MAS-like state that triggers extensive immunothrombosis, which might unmask subclinical cardiovascular disease and is distinct from the MAS and disseminated intravascular coagulation that is more familiar to rheumatologists. | 2020-08-25 |
| 32835256 | We aimed to examine whether mavrilimumab, an anti-granulocyte-macrophage colony-stimulating factor receptor-α monoclonal antibody, added to standard management, improves clinical outcomes in patients with COVID-19 pneumonia and systemic hyperinflammation. […] The main outcome was time to clinical improvement (defined as improvement of two or more points on the seven-point ordinal scale of clinical status). […] Other outcomes included proportion of patients achieving clinical improvement, survival, mechanical ventilation-free survival, and time to fever resolution. […] At day 28, all patients in the mavrilimumab group and 17 (65%) patients in the control group showed clinical improvement (p=0·030), with earlier improvement in the mavrilimumab than in the control group (mean time to improvement 8 days [IQR 5 to 11] vs 19 days [11 to >28], p=0·0001). […] Mavrilimumab treatment was associated with improved clinical outcomes compared with standard care in non-mechanically ventilated patients with severe COVID-19 pneumonia and systemic hyperinflammation. | 2020-08-25 |
| 32835257 | Treatment groups were compared using Kaplan-Meier curves and Cox regression analysis after adjusting for sex, age, recruiting centre, duration of symptoms, and baseline Sequential Organ Failure Assessment (SOFA) score. […] After adjustment for sex, age, recruiting centre, duration of symptoms, and SOFA score, tocilizumab treatment was associated with a reduced risk of invasive mechanical ventilation or death (adjusted hazard ratio 0·61, 95% CI 0·40-0·92; p=0·020). 24 (13%) of 179 patients treated with tocilizumab were diagnosed with new infections, versus 14 (4%) of 365 patients treated with standard of care alone (p<0·0001). | 2020-08-25 |
| 32835261 | We report a new phenomenon of medical care avoidance among patients with acute coronary syndrome, which is due to concerns about contracting severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection during hospital stay, ultimately leading to dire clinical outcomes. | 2020-08-25 |
| 32835265 | Once reversible causes were excluded, symptoms were related to dysfunction of the sinus node, and the patient underwent implantation of a pacemaker. | 2020-08-25 |
| 32835269 | In this report, we describe 4 cases of unexpected deaths that occurred within a short time period in patients with adult congenital heart disease without warning symptoms. | 2020-08-25 |
| 32835275 | Patients with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) comprise a unique population whose clinical course may provide insights into the effects of antiretroviral therapy on COVID-19. | 2020-08-25 |
| 32835296 | Atypical antipsychotic (AA) medications are FDA approved to treat symptoms associated with schizophrenia, bipolar disorder, depression and irritability associated with autism. […] The aim of this study was to determine if AA medications such as risperidone (RIS) alter the ability to mount an appropriate response to an acute inflammatory or adaptive immune challenge using a preclinical model. […] Short-term treatment of healthy mice with a dose of RIS that achieves plasma concentrations within the low clinical range resulted in disrupted response to an inflammatory (LPS) challenge compared to vehicle controls. | 2020-08-25 |
| 32835303 | Using a clinical SARS-CoV-2 isolate, neutralizing antibody titers are detectable in all patients by 6 days after PCR confirmation and correlate with RBD-specific binding IgG titers. […] The RBD-specific binding data were further validated in a clinical setting with 231 PCR-confirmed COVID-19 patient samples. | 2020-08-25 |
| 32835305 | COVID-19 is defined by respiratory symptoms, but cardiac complications including viral myocarditis are also prevalent. | 2020-08-25 |
| 32835306 | However, the scarcity of biologically relevant pre-clinical models of SARS-CoV-2 infection imposes a significant barrier for scientific and medical progress, including the rapid transition of potentially effective treatments to the clinical setting. | 2020-08-25 |
| 32835314 | The computational results agree with the outcome reported in early clinical reports released for a group of patients from China that confirmed a higher mortality rate in men compared with women and in older age groups. | 2020-08-25 |
| 32835326 | However, the underlying virus-host interactive characteristics conferring these observations on transmissibility and clinical manifestations of COVID-19 remain unknown. | 2020-08-25 |
| 32835346 | The aim is to further normalize the clinical procedures of radiological staff, reduce the infection risk, especially the radiation risk to medics and patients. | 2020-08-25 |
| 32835347 | Where possible, it is strongly preferred to continue visits via telehealth, and patients should be counselled about promptly reporting new symptoms. | 2020-08-25 |
| 32835351 | The overarching goal of the various HTN guidelines is to provide easily accessible information to healthcare providers and public health officials, which is key for optimal clinical practice. | 2020-08-25 |
| 32835353 | To summarize the available literature regarding bacillus Calmette-Guerin (BCG) administration, severe acute respiratory syndrome conoravirus-2 (SARS-CoV-2), and the resulting clinical condition coronavirus disease (COVID-19) in light of recent epidemiologic work suggesting decreased infection severity in BCG immunized populations while highlighting the potential role of the urologist in clinical trials and ongoing research efforts. […] Specifically, the epidemiologic evidence for decreased COVID-19 morbidity in countries with BCG vaccination programs, current clinical trials for BCG vaccination to protect against COVID-19, potential mechanisms and rationale for this protection, and the role of the urologist and urology clinic in providing support and/or leading ongoing efforts. […] Four prospective, randomized clinical trials for BCG vaccination were identified including NCT04348370 (BADAS), NCT04327206 (BRACE), NCT04328441 (BCG-CORONA), and NCT04350931. | 2020-08-25 |
| 32835425 | We completed detailed reviews of electronic medical records to collect our data. […] We complemented our baseline clinical information using telephone interviews with participants or their proxy. […] We adjusted all multivariable analyses for age, sex, clinical history, vital signs, and relevant laboratory biomarkers (lymphocyte count, C-reactive protein, glomerular filtration rate, D-dimer, and albumin). | 2020-08-25 |
| 32835459 | In the coronavirus disease 2019 (COVID-19) era, clinical registries and innovative virtual care delivery tools should be leveraged to engage populations in effective chronic disease management. | 2020-08-25 |
| 32835530 | Data were collected from the electronic base registry which contained demographic information, medical symptoms, and signs, underlying diseases, CT scan results, and final outcome. | 2020-08-25 |
| 32835666 | In this review, we will provide a basic science perspective on current clinical observations in this rapidly evolving field and discuss the interplay sex differences, preexisting CVD and COVID-19-related cardiac injury. | 2020-08-25 |
| 32835682 | This would allow reducing the susceptibility of risk groups and the cascade of events after SARS-CoV-2 infection, responsible for the clinical picture, triggered by the imbalance towards oxidation, inflammation, and cytokine storm. | 2020-08-25 |
| 32835787 | Repeat testing might prove useful in certain clinical scenarios, such as in healthcare workers, when symptoms develop after a negative test, and in hospitalized patients with a high clinical suspicion of COVID-19. | 2020-08-25 |
| 32835793 | To evaluate ocular symptoms in European non-hospitalized patients with severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and to investigate associations with the demographic data as well as nasal and general physical symptoms. […] In this prospective, observational study, 108 non-hospitalized patients with PCR-confirmed SARS-CoV-2 infection not requiring intensive care were asked about disease-associated ocular symptoms, demographic data, as well as general physical and nasal symptoms using a standardized questionnaire. […] Associations between TOSS and demographic data as well as general and nasal symptoms were evaluated. […] The most common symptoms included burning sensations in 39 (36.1%), epiphora in 37 (34.3%) and redness in 28 (25.9%), compatible with conjunctivitis. […] These symptoms occurred 1.96 ± 3.17 days after the beginning of COVID-19 and were mild. […] Overall, these ocular symptoms, including burning sensations, epiphora and redness, seem to be mild and to not need treatment. | 2020-08-25 |
| 32835900 | To analyze the incidence of the clinical presentations suggestive for COVID-19 infection among patients with Multiple Sclerosis in the province of Lecco, in the North Italy, the closest province capital to Bergamo. […] To describe the association of demographics, clinical characteristics, and use of DMTs categories with the risk of contracting the disease. […] The collected data included recent contact with a patient with COVID-19 diagnosis or a subject with respiratory symptoms and the developing of COVID-19 symptoms or a confirmed diagnosis. 15 out of 275 patients reported symptoms suggestive for COVID-19 infection, only one of them with PCR-confirmed diagnosis. […] No one of them presented severe symptoms or needed hospitalization. | 2020-08-25 |
| 32835901 | Despite complete B and T cell depletion, patient symptoms abated few days with no need for hospitalization due to COVID-19 and no clinical evidence of disease activation regarding her MS. | 2020-08-25 |
| 32835926 | Public health policy and routine clinical care need to address the potential for increased suicidal thinking among those experiencing prolonged restrictions of normal social contact. | 2020-08-25 |
| 32836010 | This is a call for a clinical multidisciplinary approach to treat and prevent Sars-Cov-2 mental health sequelae. | 2020-08-25 |
| 32836117 | This review aims to critically evaluate the incidence of gastrointestinal (GI) symptoms, the quantity and infectivity of SARS-CoV-2 in feces and urine, and whether these pose an infection risk in sanitary settings, sewage networks, wastewater treatment plants, and the wider environment (e.g. rivers, lakes and marine waters). […] The biggest risk of transmission will occur in clinical and care home settings where secondary handling of people and urine/fecal matter occurs. | 2020-08-25 |
| 32836185 | To assess the prevalence and sociodemographic correlates of insomnia symptoms among Chinese adolescents and young adults affected by the outbreak of coronavirus disease-2019 (COVID-19). […] An online survey was used to collect demographic data, and to assess recognition of COVID-19, insomnia, depression, and anxiety symptoms using the Pittsburgh Sleep Quality Index (PSQI), the Patient Health Questionnaire (PHQ-9), and the Generalized Anxiety Disorder (GAD-7) questionnaires, respectively. […] Among 11,835 adolescents and young adults included in the study, the prevalence of insomnia symptoms during part of the COVID-19 epidemic period was 23.2%. […] Binomial logistic regression analysis revealed that female sex and residing in the city were greater risk factors for insomnia symptoms. […] Depression or anxiety were risk factors for insomnia symptoms; however, social support, both subjective and objective, was protective factors against insomnia symptoms. […] Furthermore, anxiety and depression symptoms were mediators of social support and insomnia symptoms. […] The adverse impact of COVID-19 was a risk factor for insomnia symptoms; as such, the government must devote more attention to sleep disorders in this patient population while combating COVID-19. | 2020-08-25 |
| 32836299 | The aim of this work is to describe at the hospital level the changes in the professional and personal environment linked to the crisis likely to cause stress and then to describe the clinical manifestations observed both on an individual and collective level. […] In this chapter, we describe the clinical manifestations observed in the caregivers of the hospital in reaction to the crisis. | 2020-08-25 |
| 32836301 | To deal with the Covid 19 pandemic, health protection measures require changes to our clinical practices. […] The authors develop a clinical reflection on the clinical setting in a pandemic period by exploring in particular the dynamics of telephone sessions. […] We choose to illustrate our point with short vignettes than by relying on long-term clinical cases, more likely to represent the variety of new clinical situations encountered and the questions that accompany them. | 2020-08-25 |
| 32836303 | We base our thinking on a review of the literature confronted with our current clinical experience, including concerning the possibilities of dematerialised medico-psychological monitoring. | 2020-08-25 |
| 32836304 | In real life of our hospital activity is not at all true because in both clinical situations the symptomatology of infectious disease was protected about a long psychotic or pseudo psychotic episode. […] Our clinical case shows the possibility of our patients to relativize the gravity of the pandemic and his impact. […] Clinical presentation of an unlikely encounter in the context of the Covid-19 epidemic. | 2020-08-25 |
| 32836360 | Therefore, future studies should focus on clinical outcomes and treatments in COVID-19-positive orthopedic patients and prevention strategies. | 2020-08-25 |
| 32836366 | Those currently not in practice or under training or having left clinical practice before the onset of pandemic were excluded. | 2020-08-25 |
| 32836376 | We explicate the rationale and the clinical application of these relational and experiential interventions, and organize them through a comprehensive model. […] In addition to theoretical and practical suggestions, which could be adapted to various models of therapy, we present a brief clinical case demonstrating the application of the suggested therapeutic thinking and interventions. | 2020-08-25 |
| 32836378 | Finally, we illustrate with clinical vignettes how the developmental levels of mentalizing-attention control, emotion regulation, and explicit mentalizing-can inform the structure, techniques and interventions in teletherapy with children and parents. | 2020-08-25 |
| 32836394 | Due to the clinical severity intravenous antibiotic treatment was started immediately. […] The clinical condition of the infant rapidly improved but whether this was due to symptomatic or antibiotic treatment remained unknown. | 2020-08-25 |
| 32836522 | Researches in the fields of virology, infectious diseases and immunology are the most active, and we identified two characteristic patterns in global science distinguishing research in Europe and America that is more focused on public health from that conducted in China and Japan with more emphasis on biomedical research and clinical pharmacy, respectively. | 2020-08-25 |
| 32836610 | Routine and specialist obstetric ultrasound scans are essential for clinical decision-making during pregnancy, as it has a direct impact on the management of mothers and fetuses and on the perinatal outcome. | 2020-08-25 |
| 32836625 | As a result of the new coronavirus (severe acute respiratory syndrome coronavirus type 2 [SARS-CoV-2] outbreak in January 2020, many clinical studies are being carried out with the aim of combating or eradicating the disease altogether. | 2020-08-25 |
| 32836664 | Although this change has been rapidly introduced, it will most likely become a permanent feature of clinical practice. | 2020-08-25 |
| 32836666 | The aim of this study was to evaluate the clinical implications of previous treatment with ACEI/ARB on the prognosis of patients with COVID-19 infection. | 2020-08-25 |
| 32836696 | Finally, numerical performances for the proposed model as well as the comparisons between our simulations and the clinical data of the city Wuhan and Italy are demonstrated, showing the validity of our model with suitably specified model parameters. | 2020-08-25 |
| 32836709 | Thus, based on the findings, we recommend in vitro and in vivo studies and clinical trials to determine their effectiveness against COVID-19. | 2020-08-25 |
| 32836712 | Data of the date of onset, clinical details, laboratory results, history of travel, history of contact with positive case and control measures initiated were collected, analysed and compared. | 2020-08-25 |
| 32836713 | Participants had good knowledge regarding clinical symptoms, mode of transmission and preventive measures. | 2020-08-25 |
| 32836826 | Garlic and its active organosulfur compounds (OSCs) have been reported to alleviate a number of viral infections in pre-clinical and clinical investigations. […] The aim of this review is to systematically summarize pre-clinical and clinical investigations on antiviral effects of garlic and its OSCs as well as to further analyse recent findings on the mechanisms that underpin these antiviral actions. […] Pre-clinical data demonstrated that garlic and its OSCs have potential antiviral activity against different human, animal and plant pathogenic viruses through blocking viral entry into host cells, inhibiting viral RNA polymerase, reverse transcriptase, DNA synthesis and immediate-early gene 1(IEG1) transcription, as well as through downregulating the extracellular-signal-regulated kinase (ERK)/mitogen activated protein kinase (MAPK) signaling pathway. […] Clinical studies further demonstrated a prophylactic effect of garlic in the prevention of widespread viral infections in humans through enhancing the immune response. | 2020-08-25 |
| 32836862 | In the absence of a vaccine, non-clinical preventative measures have been implemented as the principal means of limiting deaths. | 2020-08-25 |
| 32836898 | The cohort of SARS-CoV‑2 infected residents of a nursing home is characteristic for clinical and epidemiological features of the new coronavirus disease. […] Thereby, increased case fatality rates of approximately 20% could in all cases be assigned to a relevant number of pre-existing comorbidities of multiple organ systems, which was consistent with the clinical data available. | 2020-08-25 |
| 32836910 | Most COVID-19 studies were clinical reports (n = 242; 60.8%). | 2020-08-25 |
| 32836917 | Also, the use of appropriate antivirals in order to alleviate the symptoms, to control the severity of the illness and to prevent the transmission, could be a good option that we study in this work. | 2020-08-25 |
| 32837030 | So, in the current review, we are exploring novel treatment strategies and therapies that are being explored and are in clinical and preclinical stages of research. […] The current scientific literature and database search were performed by exploring various Trials registry (NIH: https://clinicaltrials.gov/ and https://www.coronavirus.gov) and Chinese clinical trial registry http://www.chictr.org.cn/) and for preclinical trials various University, Institutions, Pharmaceutical companies websites and news bulletins along with google search were checked routinely from 3rd March 2020 to 16 May 2020. | 2020-08-25 |
| 32837035 | There was a need of systematic data about the COVID-19 related clinical trials conducted in India. […] The aim of the present study was to analyze various clinical trials registered in Clinical Trial Registry of India (CTRI) exploring the interventions for COVID 19. […] The data of various clinical trials being conducted in India was obtained from CTRI. […] There is a good progress regarding AYUSH clinical trials, and a similar progress is expected for allopathic interventions. | 2020-08-25 |
| 32837036 | There is a spectrum of clinical features from mild to severe life threatening disease with major complications like severe pneumonia, acute respiratory distress syndrome, acute cardiac injury and septic shock. […] The early symptoms of COVID-19 pneumonia are low to midgrade fever, dry cough and fatigue. | 2020-08-25 |
| 32837047 | There is a paucity of evidence and guidelines to support clinical decisions in the present unprecedented time. […] We aimed to use the experience and consensus of the cardiac surgeons for clinical decisions until evidence-based guidelines are formed. | 2020-08-25 |
| 32837051 | It is not meant to replace individual clinical judgment, but to provide a template to formulate local policies. | 2020-08-25 |
| 32837058 | Hungarian obstetrician Ignac Semmelweis (1818-1865) was one of the earliest clinical investigators of modern medical science. […] In nineteenth century Europe, puerperal fever (childbed fever) was a major clinical and public health problem with very high maternal mortality. […] Astute clinical observations and logical reasoning goaded Semmelweis to suspect the role of “unholy” hands of “holy” physicians in the transmission of puerperal fever. […] Clinical hand washing, since then, has prevented millions of deaths of humankind. | 2020-08-25 |
| 32837065 | Coronavirus disease 2019 (COVID-19) typically presents with pulmonary symptoms. | 2020-08-25 |
| 32837088 | The model is further extended to incorporate the infection arising from the population showing no symptoms. | 2020-08-25 |
| 32837093 | Six of these vaccines have entered clinical trials. […] As clinical trials are “rate-limiting” and “time-consuming”, many innovative methods are in practice for a fast track. | 2020-08-25 |
| 32837094 | Most of the recipients were aware of the main symptoms of COVID-19, such as fever (92%), breathlessness (86%), and dry cough (87%), but less than half were aware of diarrhea (39%) as a symptom. | 2020-08-25 |
| 32837095 | Though respiratory symptoms are the typical manifestation of this disease, gastrointestinal (GI) symptoms such as anorexia, nausea, vomiting, loss of taste sensation, diarrhea, abdominal pain, and discomfort have been reported. […] A few studies suggested that the presence of GI symptoms is associated with poorer prognosis. […] Fecal viral excretion may have clinical significance because of possible feco-oral transmission of the infection. […] Nearly, 10.5%-53% of patients with COVID-19, particularly those with severe disease, have been shown to have an elevation of hepatic enzymes though biochemical and clinical jaundice are uncommon. | 2020-08-25 |
| 32837096 | It is unclear if they can predict the clinical outcomes among hospitalized COVID-19 patients. | 2020-08-25 |
| 32837097 | There is an urgent unmet need of interventions both for prevention and treatment of this disease and more than 500 clinical trials are ongoing in this regard. […] Given the rapid pace of clinical information and discoveries, it is important for clinicians to be up to date with the latest, evidence-based treatment options available for this novel disease. […] Keeping up with this current pace of information, we review the clinical studies of different therapeutic options available to treat SARS-CoV-2. | 2020-08-25 |
| 32837100 | The objective of this study is to look over the disease through Ayurvedic perspective, analyse possible pathologies, select appropriate drugs and to study in-silico screening on these selected drugs.Materials & Methods: Available symptoms of Covid 19 were thoroughly studied and reviewed through Ayurveda classics, internet, preprints, etc. to understand the nature of the disease with the Ayurvedic perspective.The molecular Docking and Grid were generated through Pyrx Software with Autodock. […] Thus, Nagaraadi Kashayam, a classical formulation can be a trial candidate for conducting further clinical trial. | 2020-08-25 |
| 32837101 | Further pre-clinical and clinical trials need to be done for the evaluation of safety and efficacy of this polyherbal formulation. | 2020-08-25 |
| 32837103 | 138 (77.5) PG trainees contributed in the survey, and 65.1% of them stated that no clinical classes are being held presently. […] The majority (94%) confirmed that COVID-19 has affected their surgical and clinical training. | 2020-08-25 |
| 32837107 | Through summarizing and analyzing the modern mechanism researches and controversial questions of moxibustion fumigation in the epidemic prevention, the thoughts on tackling the critical points are proposed in the paper, such as the recognition of moxa smoke in traditional Chinese medicine (TCM), the mechanism of moxa smoke in air disinfection and the characteristics of clinical application of moxa smoke so as to provide the references to the prevention and control of COVID-19 in TCM. | 2020-08-25 |
| 32837108 | The prescription was modified weekly according the symptoms of the patients. | 2020-08-25 |
| 32837110 | To observe the clinical therapeutic effect of adjuvant treatment with heat-sensitive moxibustion for coronavirus disease 2019 (COVID-19) of the ordinary type. […] Before and after moxibustion, the improvements in clinical symptoms were evaluated, such as chest oppression, poor appetite, lassitude and negative emotions. […] The incidences of the symptoms were all reduced obviously as compared with those before treatment. […] Adjuvant treatment with heat-sensitive moxibustion effectively relieves the symptoms of COVID-19 such as chest oppression, poor appetite and lassitude, and alleviates the negative emotions, such as tension and anxiety. […] This therapy improves the therapeutic effect of COVID-19 and deserves to be promoted in clinical practice. | 2020-08-25 |
| 32837148 | Clinical features overlapped with Kawasaki disease, acute rheumatic fever, and toxic shock syndrome. […] After centers in Europe began reporting a multisystem inflammatory condition in children with COVID-19, the patient’s clinical course and laboratory findings were revisited. | 2020-08-25 |
| 32837192 | With the asymptomatic presentation of COVID-19 in many patients and the similarity of its symptoms with the common cold and influenza, the need for accurate information on the disease is very important for its identification and proper management. […] DICs are usually staffed by pharmacists and/or clinical pharmacists/pharmacologists. | 2020-08-25 |
| 32837194 | We sought to provide a comprehensive overview of the challenges encountered by pharmacy services in responding to the COVID-19 pandemic emergency in Brazil and discuss the role of clinical pharmacists in this context. […] COVID-19 patients may present high risk in the use of medications and clinical pharmacists can contribute substantially as part of a multidisciplinary team to improve outcomes in drug therapy in severe and critical illness. | 2020-08-25 |
| 32837211 | Measurements of cardiac biomarkers are required if myocardial damage is suspected and are part of a panel of arguments confronted with clinical features, ultrasonic monitoring and electrocardiogram. | 2020-08-25 |
| 32837217 | Clinical studies have shown that renal injury in Corona Virus Disease 2019 (COVID-19) patients has been a real concern, which is associated with high mortality and an inflammation/apoptosis-related causality. | 2020-08-25 |
| 32837277 | Major strategies in terms of clinical trials of medicines and vaccines, social distancing, use of personal protective equipment (PPE), and so on are being implemented in order to control the spread. | 2020-08-25 |
| 32837286 | Social isolation and loneliness predict all-cause mortality at rates that rival clinical risk factors, such as obesity and smoking; they are associated with greater incidence of psychological, cognitive, and physical morbidities. | 2020-08-25 |
| 32837300 | Based on the first 35 patients admitted to the hospital with COVID-19, we evaluated the various symptoms with which patients presented. […] The majority of patients have respiratory symptoms (e.g., cough and reduced peripheral oxygen saturation) and fever. […] In individual patients, however, there may only be other symptoms, e.g., gastrointestinal, neurological, or nonspecific symptoms. | 2020-08-25 |
| 32837302 | The algorithm covers some key points of decision making such as clinical signs, first contact, admission for in-patient treatment, consequences of swab and computed tomography (CT) results, and allocation and isolation measures within the hospital. | 2020-08-25 |
| 32837305 | In addition, communication and quality and risk management are highly relevant in addition to the clinical aspects. | 2020-08-25 |
| 32837342 | With a particular focus on physicians who have completed their training, it also explores the present and future of interventions designed to alleviate the symptoms and sequelae of burnout. […] Recent work has continued to outline risk factors and specialty-specific prevalence, and explore individual and institutional interventions to prevent and treat symptoms. | 2020-08-25 |
| 32837347 | Coronavirus disease 2019 (COVID19) shutdowns have impacted nursing education, particularly student clinical experiences. […] In this paper, we discuss how we adapted an accelerated MSN nursing administration clinical course to meet the needs of our practicing students and the Commission on Collegiate Nursing Education (CCNE) standards in the context of the COVID19 pandemic. | 2020-08-25 |
| 32837348 | At other hospitals, clinical nurses began to wonder what happened to shared governance. | 2020-08-25 |
| 32837354 | Nurses were interviewed about the strengths and weaknesses of the program, and for their perceptions of the additional clinical support. | 2020-08-25 |
| 32837409 | They demonstrated independence with their individualized home exercise programs in one to two sessions, did not require an in-person rehabilitation consultation, did not require increased oxygen, experienced no exacerbation of symptoms, and were discharged home. | 2020-08-25 |
| 32837412 | The spectrum of COVID-19 is broad, from clinical disease requiring intensive medical care to less severe symptoms that are treated with supportive care. […] The majority of COVID-19 cases fall into the mild-to-moderate category, with symptoms lasting less than 6 weeks. | 2020-08-25 |
| 32837414 | While COVID-19 primarily manifests with pulmonary symptoms, cardiovascular, neurologic, and other major organ systems may also be affected and present with hallmark imaging findings. […] This article reviews initial and emerging literature on clinical characteristics and imaging findings of COVID-19. | 2020-08-25 |
| 32837415 | We sought to determine the attributes, pharmacologic and other treatments, and clinical course in the cohort of patients with COVID-19 who were admitted to our hospital at the height of the pandemic in April 2020 in New York City. | 2020-08-25 |
| 32837434 | Convergent validity was found with depressive, anxious, and posttraumatic stress symptoms. | 2020-08-25 |
| 32837435 | Additionally, the FCV-19S was only moderately correlated with the Generalized Anxiety Disorder-7 Scale (GAD-7), suggesting that the FCV-19S may bring added utility to research and clinical practice with populations impacted by the COVID-19 pandemic. | 2020-08-25 |
| 32837448 | This article discusses educational strategies utilized to support clinical competency using an online format for a fundamentals of nursing clinical course. […] The authors also discuss future implications and suggestions for attaining learning objectives for a clinical course using an online format. | 2020-08-25 |
| 32837453 | In this study, an intelligence computer-aided model that can automatically detect positive COVID-19 cases is proposed to support daily clinical applications. | 2020-08-25 |
| 32837460 | By using different vaccine development platforms including whole virus vaccines, recombinant protein subunit vaccines, and nucleic acid vaccines several candidates displayed efficacy in vitro studies but few progressed to clinical trials. | 2020-08-25 |
| 32837518 | In a sample of 436 participants, about 28% stayed in self-quarantine, 22 persons had relevant symptoms and one person was positively tested for COVID-19. […] Stress symptoms in 2019 predicted a higher level of burden and PMH predicted a lower level of burden in March 2020. […] Remarkably, depression and anxiety symptoms did not significantly predict burden. […] The protective effect of PMH and the negative impact of stress symptoms were mediated by perceived sense of control. | 2020-08-25 |