DNA topoisomerase III beta

Gene Context Sentence

Table 2. Analysis of context sentence of TOP3B gene in 1 abstracts.

PMID Gene Context Sentence
32735900 Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-β (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. […] Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded RNA viruses tested, including SARS-CoV-2. […] While there are no drugs that specifically inhibit this topoisomerase, we posit that TOP3B is an attractive anti-viral target.