Gene Context Sentence

Table 2. Analysis of context sentence of TG gene in 17 abstracts.

PMID Gene Context Sentence
32397699 Objective: To describe the basic characteristics of clusters of coronavirus diseases 2019 (COVID-19) cases in Ningbo, Zhejiang province, and evaluate the generation time (Tg) and basic reproduction number (R(0)) of COVID-19. Methods: The basic information and onset times of the clusters of COVID-19 cases in Ningbo were investigated, the inter-generational interval of the cases were fitted by using gamma distribution, and the R(0) was calculated based on the SEIR model. Results: In the 15 clusters of COVID-19 cases, a total of 52 confirmed cases, 5 cases of nucleic acid- positive asymptomatic cases. […] The Tg was (6.93±3.70) days. […] There were no significant differences in Tg between age group <60 years and age group 60 years and above, and between men and women (P=0.551). […] According to the Tg calculated in this paper, the R(0) of COVID-19 in Ningbo was 3.06 (95%CI: 2.64 - 3.51); according to the reported case transmission interval of 7.5 days in the literature, the R(0) was 3.32 (95%CI: 2.51-9.38 ). Conclusion: There is no age and gender specific differences in the Tg of clusters of COVID-19 cases in Ningbo, and COVID-19 has high infectivity and spreading power in early phase. 目的: 描述新型冠状病毒肺炎(COVID-19)聚集性疫情病例的基本特征。 […] 方法: 收集15起COVID-19聚集性疫情病例的基本信息,采用伽马分布拟合病例代际间隔时间(Tg),使用基于SEIR模型计算基本再生数(R(0))。 […] Tg为(6.93±3.70) d,在<60岁、≥60岁组及男、女性之间,Tg差异无统计学意义(P=0.551)。 […] 按照本研究估算的Tg计算,宁波市新冠肺炎感染的R(0)为3.06 (95%CI:2.64~3.51);按照文献报告的病例Tg为7.5 d计算,R(0)为3.32(95%CI:2.51~9.38)。 […] 结论: COVID-19聚集性疫情病例的Tg在不同年龄、性别间差异不大,COVID-19早期致病和传播力较高。.
32667555 Despite the dismantling experienced today in the Brazilian public scene, the PEH Thematic Group (TG) of the Brazilian Association of Public Health (ABRASCO) has been helping to foster, design, and express the voicing of the construction and development of participatory educational and democratic processes in Brazil. […] This paper showcases the experiences and elaborations of the TG members through the report of the collegiate coordination center members of the last administrations, a period of changes in the political, social, economic, educational and health scenarios, including the influence of the current planetary crisis brought about by the effects of COVID-19, especially in the Brazilian society.
32731115 This research aimed to characterize pyrolysis drivers, behaviors, products, reaction mechanisms, and pathways via TG-FTIR and Py-GC/MS analyses as a function of the two medical plastic wastes of syringes (SY) and medical bottles (MB), conversion degree, degradation stage, and the four heating rates (5,10, 20, and 40 °C/min).
32733785 To characterize changes in global gene expression in the hearts and kidneys of rtTA/hACE2 double transgenic (dTg) mice in response to hACE2 overexpression, total RNA extracted from these tissues from dTg mice after doxycycline (Dox) treatment was hybridized to oligonucleotide microarrays. […] Briefly, dTg mice were generated by cross-mating pα-MHC/rtTA Tg mice with pTRE/hACE2 Tg mice. […] The expression level of hACE2 protein was determined to be high in hearts, kidneys, and brains of dTg mice, whereas lung, liver, and testis tissues expressed low levels. […] The level of hACE2 was significantly enhanced in hearts and kidneys of the Dox+dTg group compared to that in Vehicle+dTg mice although consistent levels of mouse ACE2 (mACE2) remained in the same tissues. […] Based on the microarray analysis of heart tissue, 385 genes were differentially expressed, including 168 upregulated and 217 downregulated, when comparing non-Tg and Vehicle+dTg mice, whereas 216 genes were differentially expressed, including 136 upregulated and 80 downregulated, between Vehicle+dTg and Dox+dTg mice. […] In the kidneys, 402 genes were differentially expressed, including 159 upregulated and 243 downregulated, between non-Tg and Vehicle+dTg mice. […] Dox-treated dTg mice exhibited the differential expression of 4735 genes including 1636 upregulated and 3109 downregulated. […] Taken together, these findings suggested that several functional groups and individual genes can be considered biomarkers that respond to hACE2 overexpression in dTg mice. […] Moreover, our results provided a lot of useful information to predict physiological responses when these dTg mice are applied as a susceptible model for novel coronavirus (SARS-CoV, COVID-19) in both vaccine and drug development.
32790951 We read with much interest the recent observational study of Nougier et al., which aimed at studying thrombin generation (TG) and fibrinolysis profiles of COVID-19 patients admitted to an intensive care unit (ICU) or to an internal medicine ward and receiving various schemes of prophylactic heparin.[
32808185 Using transcriptomic datasets, Toxicogenomic Project-Genomics Assisted Toxicity Evaluation System (Open TG-GATEs) and GSE30351, we have tested the ability of ninety common medications to regulate COVID-19 receptors expression in human primary hepatocytes.
32974230 An article published by Ksiazek TG et al in the New England Journal of Medicine had the maximum citation (n=2175); 90% of the research outputs were articles, broadly classified under Infectious diseases (n=5341); and the most commonly used keyword was ‘Coronavirus’.
32987541 Due to the unobservability, the time interval between transmission generations (TG), though important for understanding the disease transmission patterns, of COVID-19 cannot be directly summarized from surveillance data. […] In this study, we develop a likelihood framework to estimate the TG and the pre-symptomatic transmission period from the serial interval observations from the individual transmission events. […] As the results, we estimate the mean of TG at 4.0 days (95%CI: 3.3-4.6), and the mean of pre-symptomatic transmission period at 2.2 days (95%CI: 1.3-4.7).
33122929 Triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio is an indicator of insulin resistance. […] This study aimed to explore the association of the TG/HDL-C ratio with cardiovascular risk and prognosis in COVID-19. […] Regression models were used to investigate the association between TG/HDL-C ratio with myocardial injury, heart failure, severity, and mortality in COVID-19. […] Increased TG/HDL-C ratio was independently associated with myocardial injury, heart failure, disease severity, and mortality in patients with COVID-19, and it may be a useful marker for early identification of patients with high risk and poor outcome.
33177251 Serum thyroglobulin (Tg) concentration was normal in the presence of anti-Tg antibody, other thyroid-related autoantibodies were negative, and by ultrasonography, the thyroid gland was normal in size and no evidence of increased vascularity.
33194061 There were significant differences on hypertension, abidol treatment, serum alanine aminotransferase (ALT), lymphocyte counts, and serum triglyceride (TG) between two groups (P<0.05). […] Further logistic regression analysis showed that TPNT was highly associated with serum TG level and hypertension that were related to the expression of ACE2, the targeting protein for the invasion of SARS-CoV-2.
33262790 We conducted multivariable logistic regression to evaluate the observational associations between obesity traits (body mass index [BMI], waist circumference [WC]), quantitative cardiometabolic parameters (systolic blood pressure [SBP], serum glucose, serum glycated hemoglobin [HbA1c], low-density lipoprotein [LDL] cholesterol, high-density lipoprotein [HDL] cholesterol and triglycerides [TG]) and SARS-CoV-2 positivity in the UK Biobank cohort.
33282265 = 74) exhibited higher TG and HDL-C, and lower LDL-C. […] Compared with the LOS ≤ 29 days group, serum levels of TC, HDL-C, and LDL-C were significantly lower in the LOS > 29 days group at admission; this lower trend was found in the subsequent tests for TC and LDL-C but not for HDL-C or TG.
33441263 Glucose, LDL-C, and TG increased in diabetic (39.69 ± 74.69, 7.60 ± 34.33, and 58.21 ± 133.54 mg/dl, p < 0.05) whereas non significantly decreased in non-diabetic group (-0.51 ± 4.40, -3.52 ± 14.53, and -6.47 ± 41.77 mg/dl, respectively. […] After adjusting BMI, increase in blood glucose (p = 0.021), HbA1c (p = 0.018), and TG (p = 0.041) levels were more in diabetic than non-diabetic group. […] This is the first study to show that prolonged lockdown COVID-19 pandemic worsened glucose regulation and increased TG level in diabetes mellitus independent of weight gain.
33544518 Thrombin generation (TG) with and without thrombomodulin (TM) was evaluated in COVID-19 patients with different disease severity and thromboprophylaxis regimen, in order to understand the prothrombotic profile. […] Overall, patients with COVID-19 showed a TG profile comparable to that of healthy subjects (i.e. comparable peak height, endogenous thrombin potential [ETP] with and without TM). […] MD patients showed a similar TG profile to healthy controls, and ICU patients showed significantly decrease ETP (p=0.030) compared to MD. […] As for thromboprophylaxis, TG profile was significantly increased in COVID-19 patients without thromboprophylaxis vs. controls and vs. those with thromboprophylaxis. […] However, patients with thromboprophylaxis had similar TG profile vs. controls. […] Intermediate dose thromboprophylaxis more effectively inhibited TG in severe COVID-19 patients by increasing ETP inhibition via ETP with TM reduction vs. standard dose. […] COVID-19 patients showed increased TG at diagnosis. […] Standard thromboprophylaxis reduced TG to levels of healthy controls. […] Intermediate sub-therapeutic thromboprophylaxis more effectively inhibited TG by decreasing ETP with TM.
33546185 Here we show that TG is also highly effective in blocking the replication of respiratory syncytial virus (RSV), common cold coronavirus OC43, SARS-CoV-2 and influenza A virus in immortalized or primary human cells. […] TG’s antiviral performance was significantly better than remdesivir and ribavirin in their respective inhibition of OC43 and RSV. […] Notably, TG was just as inhibitory to coronaviruses (OC43 and SARS-CoV-2) and influenza viruses (USSR H1N1 and pdm 2009 H1N1) in separate infections as in co-infections. […] Post-infection oral gavage of acid-stable TG protected mice against a lethal influenza virus challenge. […] Together with its ability to inhibit the different viruses before or during active infection, and with an antiviral duration of at least 48 h post-TG exposure, we propose that TG (or its derivatives) is a promising broad-spectrum inhibitor against SARS-CoV-2, OC43, RSV and influenza virus.
33571404 Eighty-six severe COVID-19 patients, 132 non-severe COVID-19 patients and 76 healthy individuals (control group) were recruited to measure triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) using enzyme-coupled colorimetry.