APC


APC regulator of WNT signaling pathway


Gene Context Sentence


Table 2. Analysis of context sentence of APC gene in 6 abstracts.

PMID Gene Context Sentence
32338613 Search volume values and average peak comparison (APC) values were used to analyze the results. […] The top five searches related to health were “face masks,” “amuchina” (disinfectant), “symptoms of the novel coronavirus,” “health bulletin,” and “vaccines for coronavirus.” The regions of Umbria and Basilicata recorded a high number of infodemic monikers (APC weighted total >140). […] These monikers were frequently searched (APC weighted total >100) in more than 10 major cities in Italy, including Rome.
32432519 We discuss the possible excess risk for COVID-19 infection in the context of the common conditions among shiftworkers, including nurses, doctors, and first responders, among others of high exposure to the contagion, of sleep imbalance and circadian disruption.Abbreviations: ACE2: Angiotensin-converting enzyme 2; APC: Antigen-presenting cells; CCL: Chemokine (C-C motif) ligand; CD+: Adhesion molecule expression; COVID-19: 2019 coronavirus disease; DCs: Dendritic cells; GH: Growth hormone; HPA: Hypothalamic-pituitary-adrenal; HSF: Heat shock factor; HSP70: Heat shock protein 70; HSP90: Heat shock protein 90; IL: Interleukin; INFγ: Interferon-gamma; LT/LB: T/B lymphocytes; MHC: Major histocompatibility complex; NK: Natural killer; RAAS: renin-angiotensin-aldosterone system; SARS: Severe acute respiratory syndrome; SCN: Suprachiasmatic nucleus;SD: Sleep deprivation; SNS: Sympathetic nervous system; Th1/Th2: T helper lymphocytes 1/2; TLR2/TLR4: Toll-like receptor 2/4; TNF-α: Tumor necrosis factor alpha; VEGF: Vascular endothelial growth factor.
32493460 The present study is a multi-site, parallel group, randomized controlled trial (RCT) comparing the effectiveness of the CoVideo against an attention placebo control (APC) video or no video. […] The trial has an intervention arm (CoVideo), placebo arm (APC), and control arm (no video). […] Arm 2: the APC video, list experiment, questionnaire survey, and CoVideo. […] The comparators are an APC video (Arm 2) or no video (Arm 3). […] The APC video is similar in style to the CoVideo; it is also animated with a duration of 2.30 minutes, has sound effects but no words, speech, or text. […] Using a web-based randomization algorithm, Gorilla will randomly allocate participants to the intervention (CoVideo), placebo (APC), or control (no video) arm (sequence generation) at a 1:1:1 ratio.
32544622 In a multivariable logistic regression that included age, ECG, and clinical characteristics, the presence of one or more atrial premature contractions (APC)s (odds ratio (OR)=2.57, 95% confidence interval (CI) 1.23-5.36, p=0.01), a right bundle branch block (RBBB) or intraventricular block (IVB) (OR=2.61, 95% CI 1.32-5.18, p=0.002), ischemic T-wave inversion (OR=3.49, 95% CI 1.56-7.80, p=0.002), and nonspecific repolarization (OR=2.31, 95% CI 1.27-4.21, p=0.006) increased the odds of death. […] We found that patients with ECG findings of both left sided heart disease (APCs, IVB, repolarization abnormalities) and right sided disease (RBBB) have higher odds of death.
32548551 In preclinical studies, activated protein C (APC) provides negative feedback downregulation of excessive inflammation and thrombin generation, attenuates damage caused by ischemia-reperfusion in many organs including lungs, and reduces death caused by bacterial pneumonia. […] APC exerts both anticoagulant activities and direct cell-signaling activities. […] The APC mutant 3K3A-APC, which was engineered to have diminished anticoagulant activity while retaining cell-signaling actions, was safe in phase 1 and phase 2 human trials. […] Because of its broad spectrum of homeostatic effects in preclinical studies, we speculate that 3K3A-APC merits consideration for clinical trial studies in appropriately chosen, seriously ill patients with COVID-19.
32576678 Infected cells upregulate the CD47 “don’t eat me” signal, which slows the phagocytic uptake of dying and viable cells as well as downstream antigen-presenting cell (APC) functions.