TRIB3


tribbles pseudokinase 3


ENTREZID: 57761 | Type: Protein Coding | Map: 20p13

OMIM: 618193 | 605086


Summary Entrez
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]