PROC


protein C, inactivator of coagulation factors Va and VIIIa


ENTREZID: 5624 | Type: Protein Coding | Map: 2q14.3

OMIM: 609819


Summary Entrez
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]