endoplasmic reticulum aminopeptidase 1
Gene Context Sentence
Table 2. Analysis of context sentence of ERAP1 gene in 3 abstracts.
|Gene Context Sentence
|This variant, unlike ERAP2-wt, is unable to trim peptides to be loaded on MHC class I molecules, but it can still dimerize with both ERAP2-wt and ERAP1-wt, thus contributing to profiling an alternative cellular immune-peptidome.
|Here, we analyzed the proteolytic processing of overlapping precursor peptides spanning the entire sequence of the S1 spike glycoprotein of SARS-CoV-2, by three key enzymes that generate antigenic peptides, aminopeptidases ERAP1, ERAP2, and IRAP. […] ERAP1 was the most efficient in generating peptides 8-11 residues long, the optimal length for HLA binding, while IRAP was the least efficient. […] The combination of ERAP1 with ERAP2 greatly limited the variability of peptide sequences produced.
|ERAP1 and ERAP2 are two RAS regulators and key components of MHC class I antigen processing. […] Based on their involvement in the RAS, we believe that the dysfunctional status of ERAP1 and ERAP2 enzymes may exacerbate the effect of SARS-CoV-2 infection, aggravating the symptomatology and clinical outcome of the disease.