ATM

ATM serine/threonine kinase

Gene Context Sentence


Table 2. Analysis of context sentence of ATM gene in 8 abstracts.

PMID Gene Context Sentence
32405156 Hydroxychloroquine (CLQ-OH)/azithromycin (ATM) combination therapy is currently being tested for the treatment of COVID-19, with promising results. […] Unexpected molecular similarity is shown between ATM and the sugar moiety of GM1, a lipid raft ganglioside acting as a host attachment cofactor for respiratory viruses. […] Due to this mimicry, ATM interacts with the ganglioside-binding domain of SARS-CoV-2 spike protein. […] This binding site shared by ATM and GM1 displays a conserved amino acid triad Q-134/F-135/N-137 located at the tip of the spike protein. […] Taken together, these data show that ATM is directed against the virus, whereas CLQ-OH is directed against cellular attachment cofactors. […] This molecular mechanism may explain the beneficial effects of CLQ-OH/ATM combination therapy in patients with COVID-19.
32647730 [This corrects the article DOI: 10.21037/atm-20-3754.].
32862840 Hydroxychloroquine (CLQ-OH)/azithromycin (ATM) combination therapy is currently being tested for the treatment of COVID-19, with promising results. […] Unexpected molecular similarity is shown between ATM and the sugar moiety of GM1, a lipid raft ganglioside acting as a host attachment cofactor for respiratory viruses. […] Due to this mimicry, ATM interacts with the ganglioside-binding domain of SARS-CoV-2 spike protein. […] This binding site shared by ATM and GM1 displays a conserved amino acid triad Q-134/F-135/N-137 located at the tip of the spike protein. […] Taken together, these data show that ATM is directed against the virus, whereas CLQ-OH is directed against cellular attachment cofactors. […] This molecular mechanism may explain the beneficial effects of CLQ-OH/ATM combination therapy in patients with COVID-19.
32926682 Respiratory viral illnesses are associated with diverse neurological complications, including acute transverse myelitis (ATM). […] While there are currently no published reports on post-infectious ATM secondary to SARS-CoV-2, there is one report of parainfectious ATM attributed to SARS-CoV-2 in pre-print. […] Here, we present a case of infectious ATM attributed to SARS-CoV-2 in a 24-year-old male who presented with bilateral lower-extremity weakness and overflow urinary incontinence after confirmed SARS-CoV-2 infection. […] The patient underwent further workup and treatment with intravenous corticosteroids with improvement of symptoms and a discharge diagnosis of ATM secondary to SARS-CoV-2.
33100579 Due to the thermodynamic requirement of lower operating pressure and higher operating pressure, currently, there is no single operational approach, although some practice approaches (220 °C at 48 atm using copper) and zinc oxide/alumina are suggested for optimal performance.
33145338 [This corrects the article DOI: 10.21037/atm.2020.03.229.].
33501700 Random swabs were also taken from public shops, pharmacies, bakeries, groceries, banknotes, and automated teller machines (ATMs). […] Although no positive swabs were found in shops and public facilities, random ATM swabs returned a positive result for SARS-CoV-2. […] Additionally, high-touch public surfaces such as ATMs require further disinfection procedures to limit the transmission of the infection.
33517789 The aim of the present study was to investigate the pharmacological mechanism of matrine in treatment of COVID-19 combined with liver injury. […] The results show that six core targets including AKT1, TP53, TNF, IL6, BCL2L1 and ATM were identified. […] Real-time RT-PCR demonstrated that matrine could significantly reduce the expression of AKT1, TP53, TNF, IL6 and ATM in mice with liver injury or lung injury (P < 0.05), and increase the expression of BCL2L1 to a certain extent (P > 0.05).