transmembrane protein 41B
Gene Context Sentence
Table 2. Analysis of context sentence of TMEM41B gene in 2 abstracts.
|Gene Context Sentence
|Based on these results, we focused our efforts on characterizing the roles that TMEM41B and VMP1 play in the virus replication cycle. […] Our mechanistic studies on TMEM41B revealed that all members of the Flaviviridae family that we tested require TMEM41B. […] We tested 12 additional virus families and found that SARS-CoV-2 of the Coronaviridae also required TMEM41B for infection. […] Based on our mechanistic studies, we propose that TMEM41B is recruited to flavivirus RNA replication complexes to facilitate membrane curvature, which creates a protected environment for viral genome replication.
|We identified an absolute requirement for the VMP1, TMEM41, and TMEM64 (VTT) domain-containing protein transmembrane protein 41B (TMEM41B) for infection by SARS-CoV-2 and three seasonal coronaviruses.