G protein-coupled receptor 4
Gene Context Sentence
Table 2. Analysis of context sentence of GPR4 gene in 1 abstracts.
|PMID||Gene Context Sentence|
|33553219||Herein, we hypothesize that GPR4 plays an integral role in COVID-19 pathophysiology and is a potential therapeutic target for the treatment of COVID-19. […] GPR4 is a pro-inflammatory G protein-coupled receptor (GPCR) highly expressed in vascular endothelial cells and serves as a “gatekeeper” to regulate endothelium-blood cell interaction and leukocyte infiltration. […] GPR4 also regulates vascular permeability and tissue edema under inflammatory conditions. […] Therefore, we hypothesize that GPR4 antagonism can potentially be exploited to mitigate the hyper-inflammatory response, vessel hyper-permeability, pulmonary edema, exudate formation, vascular thromboembolism and tissue injury associated with COVID-19.|