pannexin 1

Gene Context Sentence

Table 2. Analysis of context sentence of PANX1 gene in 1 abstracts.

PMID Gene Context Sentence
32519892 Pannexin1 (PANX1) is a ubiquitously expressed, channel-forming protein found in a number of tissues thoughout the body (e.g. lung, vasculature, liver, central nervous system, immune system) that is important in many key physiological and immune responses. […] PANX1 channels passively flux ATP (predominantly), multiple metabolites, and likely other small anions. […] PANX1 channels regulate inflammation and host responses to several pathogens, including viruses. […] While there is currently no evidence suggesting novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and PANX1 directly interact, there is an urgent need for therapeutic strategies, especially those targeting the hyper-inflammation and cytokine storm that occurs in severe cases of COVID-19. […] Here we argue that PANX1, and drugs known to target PANX1 (including the FDA-approved drug probenecid), should be the focus of further investigation in the context of SARS-CoV-2 infection and its associated pathology in COVID-19 patients.