sirtuin 1

Gene Context Sentence

Table 2. Analysis of context sentence of SIRT1 gene in 11 abstracts.

PMID Gene Context Sentence
32267139 Sirtuin 1 (SIRT1) and hsa-miR-217 has been identified to mediate the development of non-small cell lung cancer (NSCLC). […] We performed this study to investigate the roles of hsa-miR-217, its target SIRT1, as well as P53/KAI1 axis in the brain metastasis from NSCLC. […] Human pulmonary adenocarcinoma brain metastasis cell line PC-14/B were incubated and treated with constructed lentiviral plasmids expressing miR-217 and/or SIRT1. […] The targeted regulation of miR-217 to SIRT1 was examined using dual luciferase reporter assay. […] Cell proliferation, migration, invasion and the expression of relate proteins were detected to examine the effect of miR-217/SIRT1 expression on metastasis. […] PC-14/B cells expressed higher SIRT1 and lower p53 and KAI1 compared with BEAS-2B control cells (P<0.05). […] SIRT1 was a direct target of miR-217. […] MiR-217 expression suppressed PC-14/B cell invasion (P=0.004), migration (P=0.001) and proliferation (P<0.05), whereas SIRT1 overexpression reversed all processes. […] SIRT1 expression inhibited P53, KAI1/CD82, matrix metalloproteinase (MMP)-9 and β-catenin but upregulated E-cadherin protein. […] Hsa-miR-217 and its target SIRT1 acted as metastasis suppressor and promoter gene in NSCLC, respectively. […] The hsa-miR-217/SIRT1/P53/KAI1 metastasis regulatory pathway showed novel and crucial roles in brain metastasis from NSCLC.
32338224 In turn, Sirt1 down-regulates AT1R expression via ACE2 up-regulation [43, 48].
32558516 Objectives: this review is to study the sirtuins involved in cancer, as well as SIRT1 inhibition studies in patients with coronavirus disease COVID-19. […] SIRT1 inhibition reduces CD8 T cell cytotoxicity in patients with systemic erythematosus lupus, being susceptible to SARS Cov-2 infections. […] It is concluded that SIRT1, SIRT2 and SIRT4 are involved in the development of cancer, the suppression of SIRT5 and SIRT7 promotes the apoptosis of cancer cells and SIRT6 attenuates the replication of KSHV, in addition to the molecular pathology pathway of COVID-19 is associated with the inhibition of SIRT1 activity that may be related to inflammatory processes. […] Las proteínas desacetilasas dependientes del NAD+, se denominan Sirtuinas (SIRT). estudiar las sirtuinas involucradas en el cáncer, así como los estudios de inhibición de SIRT1 en pacientes con la enfermedad del coronavirus COVID-19. […] La inhibición de SIRT1 disminuye la citotoxicidad de las células T CD8 en pacientes con lupus eritematoso sistémico, siendo susceptibles a infecciones por SARS CoV-2. […] Se concluye que las SIRT1, SIRT2 y SIRT4 están involucradas en el desarrollo del cáncer, la supresión de SIRT5 y SIRT7 promueve la apoptosis de células cancerígenas y la SIRT6 atenúa la replicación de KSHV, además la vía de patología molecular de la COVID-19 está asociada a la inhibición de la actividad de SIRT1 que puede estar relacionada a procesos inflamatorios.
32593740 ACE2 is regulated in the human cells by different genes associated with increased (TLR3, HAT1, HDAC2, KDM5B, SIRT1, RAB1A, FURIN and ADAM10) or decreased (TRIB3) virus replication.
32685191 What makes the argument somewhat obtuse for ACE inhibitors or ARBs is that ACE2 receptor expression can be increased by compounds that activate or increase the expression of SIRT1.
32758884 Further consumption of NAD+ in a pre-existent depleted state is more likely to cause progression to the hyperinflammatory stage of the disease through its limiting effects on the production of SIRT1. […] This provides a unifying hypothesis as to why these groups are at high risk of mortality and suggests that nutritional support with NAD+ and SIRT1 activators, could minimise disease severity if administered prophylactically and or therapeutically.
32985211 It was also reported to promote SIRT1 and p53 signaling pathways and increase cytotoxic T lymphocytes (CTLs) and natural killer (NK) immune cells.
33183203 An innovative strategy involves the vitamin nicotinamide and the pathways associated with the silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1), the mechanistic target of rapamycin (mTOR), mTOR Complex 1 (mTORC1), mTOR Complex 2 (mTORC2), AMP activated protein kinase (AMPK), and clock genes. […] However, the pathways of nicotinamide, SIRT1, mTOR, AMPK, and clock genes are complex and involve feedback pathways as well as trophic factors such as erythropoietin that require a careful balance to ensure metabolic homeostasis.
33509217 Activation or inhibition of the NLRP3 inflammasome is affected by regulators such as TXNIP, SIRT1 and NRF2.
33549591 /NADH and SIRT1 that drive redox pathways.
33578018 We studied the role and impact of p53 and deacetylase Sirtuin 1 (SIRT1) on lymph-monocyte homeostasis and their possible effect on T and B cell signalling. […] Deacetylase Sirtuin 1 (SIRT1) expression was significantly decreased in COVID-19 patients, and was negatively correlated with p53 (p = 0.003 r=-0.48). […] Inflammatory cytokines correlated positively with p53 (IL-1β: r = 0.5, p = 0.05;IL-8: r = 0.5, p = 0.05) and negatively with SIRT1 (IL1-β: r=-0.5,p = 0.04;TNF-α: r=-0.4, p = 0.04). […] Collectively, our data indicate that the inflammatory environment, the dysregulated p53/SIRT1 axis and low expression of IL7R and BLNK may impact cell survival, B cell signalling and antibody production in COVID-19 patients.