TIGIT


T cell immunoreceptor with Ig and ITIM domains


ENTREZID: 201633 | Type: Protein Coding | Map: 3q13.31

OMIM: 618213 | 219700 | 190180 | 131300


Summary Entrez
This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]