complement C3

Gene Context Sentence

Table 2. Analysis of context sentence of C3 gene in 3 abstracts.

PMID Gene Context Sentence
32359943 Reduced complement C3 could be seen in 57% of the infected HCWs and IL-6 was significantly elevated in 86% of them.
32360516 While a “cytokine storm” involving IL-6 and other cytokines has been documented, complement C3 activation has been implicated as an initial effector mechanism that exacerbates lung injury in preclinical models of SARS-CoV infection. […] C3-targeted intervention may provide broader therapeutic control of complement-mediated inflammatory damage in COVID-19 patients. […] Herein, we report the clinical course of a patient with severe ARDS due to COVID-19 pneumonia who was safely and successfully treated with the compstatin-based complement C3 inhibitor AMY-101.
32405877 C3 knockout mice infected with SARS-CoV had less lung disease than wild-type mice, suggesting that complement may play a role in coronavirus pathogenesis.