ATM serine/threonine kinase

Gene Context Sentence

Table 2. Analysis of context sentence of ATM gene in 1 abstracts.

PMID Gene Context Sentence
32405156 Hydroxychloroquine (CLQ-OH)/azithromycin (ATM) combination therapy is currently being tested for the treatment of COVID-19, with promising results. […] Unexpected molecular similarity is shown between ATM and the sugar moiety of GM1, a lipid raft ganglioside acting as a host attachment cofactor for respiratory viruses. […] Due to this mimicry, ATM interacts with the ganglioside-binding domain of SARS-CoV-2 spike protein. […] This binding site shared by ATM and GM1 displays a conserved amino acid triad Q-134/F-135/N-137 located at the tip of the spike protein. […] Taken together, these data show that ATM is directed against the virus, whereas CLQ-OH is directed against cellular attachment cofactors. […] This molecular mechanism may explain the beneficial effects of CLQ-OH/ATM combination therapy in patients with COVID-19.