Gene Context Sentence

Table 2. Analysis of context sentence of CP gene in 109 abstracts.

PMID Gene Context Sentence
32253318 One dose of 200 mL of convalescent plasma (CP) derived from recently recovered donors with the neutralizing antibody titers above 1:640 was transfused to the patients as an addition to maximal supportive care and antiviral agents. […] The primary endpoint was the safety of CP transfusion. […] The second endpoints were the improvement of clinical symptoms and laboratory parameters within 3 d after CP transfusion. […] The median time from onset of illness to CP transfusion was 16.5 d. […] After CP transfusion, the level of neutralizing antibody increased rapidly up to 1:640 in five cases, while that of the other four cases maintained at a high level (1:640). […] This study showed CP therapy was well tolerated and could potentially improve the clinical outcomes through neutralizing viremia in severe COVID-19 cases. […] The optimal dose and time point, as well as the clinical benefit of CP therapy, needs further investigation in larger well-controlled trials.
32276333 Assay reproducibility in terms of cycle threshold (Cp) values was satisfactory, with the total imprecision (% CV) values well below 5%.
32296259 One postexposure prophylaxis, convalescent (immune) plasma (CP), has shown some success in China and previously in the cure and therapy of other coronaviruses, SARS-1 and Middle East respiratory syndrome. […] Drawn from current patients who are infected with COVID-19, its CP (human anti-SARS-CoV-2 plasma) might be one way to modulate the infectivity of this virus or its effects postinfection.
32302411 It is essential that the clinical pharmacology (CP) characteristics of AZ be considered in planning and conducting clinical trials of AZ alone or in combination with other agents, to ensure safe study conduct and to increase the probability of achieving definitive answers regarding efficacy of AZ in the treatment of COVID-19. […] It also provides basic CP information relevant for planning and initiating COVID-19 clinical studies with AZ, summarizes safety data from healthy volunteer studies, and safety and efficacy data from phase II and phase II/III studies in patients with uncomplicated malaria, including a phase II/III study in pediatric patients following administration of AZ and CQ in combination.
32320384 Anti-SARS-CoV-2 virus antibody levels in convalescent plasma (CP), which may be useful in severe Anti-SARS-CoV-2 virus infections, have been rarely reported. […] The patient treated with CP did not require mechanical ventilation 11 days after plasma transfusion, and was then transferred to a general ward. […] Our serological findings in convalescent plasma from recovered patients may help facilitate understanding of the SARS-CoV-2 infection and establish CP donor screening protocol in COVID-19 outbreak. […] CP was also utilized for the treatment of one severe COVID-19 patient.
32336317 This review discusses the updates on specimens/samples, recent efficient diagnostics, and therapeutic approaches to control the disease and repurposed drugs mainly focusing on chloroquine/hydroxychloroquine and convalescent plasma (CP).
32380316 Convalescent plasma (CP) constitutes the first option in the current situation, since it has been successfully used in other coronaviruses outbreaks. […] Herein, we discuss the possible mechanisms of action of CP and their repercussion in COVID-19 pathogenesis, including direct neutralization of the virus, control of an overactive immune system (i.e., cytokine storm, Th1/Th17 ratio, complement activation) and immunomodulation of a hypercoagulable state. […] All these benefits of CP are expected to be better achieved if used in non-critically hospitalized patients, in the hope of reducing morbidity and mortality.
32388470 The lower limit of detection (LOD) for both target genes resulted the same: 3.2 (CI: 2.9-3.8) log10 cp/mL and 0.40 (CI: 0.2-1.5) TCID50/mL for S gene while 3.2 log10 (CI: 2.9-3.7) log10 cp/mL and 0.4 (CI: 0.2-1.3) TCID50/mL for ORF1ab. […] The LOD obtained with extracted viral RNA for both S gene or ORF1ab was 2.7 log10 cp/mL.
32388471 The Envelope (E) Gene-LDT displayed good analytical performance with an LoD of 95.55 cp/mL and no false positives during evaluation of cross-reactivity.
32418663 Cold plasma (CP) has entered this field as a novel, efficient, and clean solution for virus inactivation. […] We present recent developments in this promising field of CP-mediated virus inactivation, and describe the applications and mechanisms of the inactivation.
32420691 Convalescent plasma (CP), plasma collected from individuals who have recovered from an infectious disease, has been used to confer therapeutic benefits in previous epidemics, including measles, mumps, and influenza, and remains the first line passive immunotherapy in emerging diseases, including the H1N1 influenza pandemic (2009) and now Covid-19 (1).
32438330 This clinical protocol has not proven sufficient to save the lives of COVID-19 patients suffering from diabetes or having underlying liver diseases; hence there is utmost need to tackle this situation by other means such as Convalescent Plasma (CP) therapy. […] The CP therapy can be a possible life saving alternative to treat critical COVID-19 patients having diabetes or underlying liver dysfunction.
32450629 Convalescent plasma (CP) therapy refers to a therapy infusing plasma from recovered donors into other infected individuals. […] Considering the absence of specific treatments, CP has been used for treating COVID-19 and achieved some efficacies. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS.
32450629 Convalescent plasma (CP) therapy refers to a therapy infusing plasma from recovered donors into other infected individuals. […] Considering the absence of specific treatments, CP has been used for treating COVID-19 and achieved some efficacies. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS.
32450629 Convalescent plasma (CP) therapy refers to a therapy infusing plasma from recovered donors into other infected individuals. […] Considering the absence of specific treatments, CP has been used for treating COVID-19 and achieved some efficacies. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS.
32450629 Convalescent plasma (CP) therapy refers to a therapy infusing plasma from recovered donors into other infected individuals. […] Considering the absence of specific treatments, CP has been used for treating COVID-19 and achieved some efficacies. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS.
32491199 Convalescent plasma (CP) therapy is a potentially effective treatment option. […] COVID-19 convalescent plasma (CCP)-specific donor screening and selection were performed based the following criteria: 1) aged 18-55 years; 2) eligible for blood donation; 3) diagnosed with COVID-19; 4) had two consecutive negative COVID-19 nasopharyngeal swab tests based on PCR (at least 24 h apart) prior to hospital discharge; 5) had been discharged from the hospital for more than 2 weeks; and 6) had no COVID-19 symptoms prior to convalescent plasma donation. […] In addition, preference was given to CCP donors who had a fever lasting more than 3 days or a body temperature exceeding 38.5 Celsius, and 4 weeks after the onset of symptoms. […] CCP collection was performed using routine plasma collection procedures via plasmapheresis. […] In addition to routine donor testing, the CCP donors’ plasma was also tested for SARS-CoV-2 nucleic acid and S-RBD-specific IgG antibody. […] Of the 81 potential CCP donors, 64 (79%) plasma products were collected. […] The average time between CCP collection and initial symptom onset was 49.1 days, and the average time between CCP collection and hospital discharge was 38.7 days. […] The average volume of CCP collected was 327.7 ml. […] In addition, all of the CCP donors’ plasma units were negative for SARS-CoV-2 RNA. […] Of the total 64 CCP donors tested, only one had an S-RBD-specific IgG titer of 1:160, all others had a titer of ≥1:320. […] Based on a feasibility study of a pilot CCP program in Wuhan China, we demonstrated the success and feasibility of CCP collection. […] In addition, all of the CCP units collected had a titer of ≥ 1:160 for S-RBD-specific IgG antibody, which met the CCP quality control requirements based on the Chinese national guidelines for CCP.
32516739 Cycle threshold (Cp) values of the LightMix® E-gene kit and in-house assays showed excellent correlation. […] Reproducibility of the Cp values was satisfactory with intra- and inter-assay coefficient of variation values <5%.
32538806 El objetivo de esta publicaciónes proporcionar recomendaciones en el manejo del cáncer de próstata (CP) en el marco de la nueva realidad que supone la presencia de la COVID-19. […] Los autores definieron diferentes prioridades para los distintos supuestos clínicos en CP. […] Acorde a esta clasificación, el grupo de trabajo consensuó la distribución de los diferentes escenarios diagnósticos, terapéuticos y de seguimiento del CP. […] El riesgo de morbilidad grave como resultado de la infección por SARS-CoV-2puede superar el riesgo de morbi-mortalidad por CP en muchos hombres; por lo tanto, a corto plazo es pocoprobable que los retrasos en el diagnóstico o tratamiento conduzcan a peores resultados oncológicos. […] La pandemia COVID-19 ha resultado en un desafío para nuestro sistema de salud, lo que plantea varias consideraciones en el tratamiento de pacientes con CP.
32540345 Among the various treatment proposals for COVID-19 infection, passive immunotherapy using plasma from recovering patients - “convalescent plasma” (CP)- could be a promising option in the treatment of SARS-CoV-2 infections. […] The Food and Drug Administration (FDA), the U.S. regulatory authority, has approved the use of CP for compassionate use in the treatment of patients with a critical COVID-19 infection.
32560646 Convalescent plasma (CP) transfusion was reported to be effective in treating critically ill patients with COVID-19, and hydroxychloroquine could potently inhibit SARS-CoV-2 in vitro. […] Herein, we reported a case receiving combination therapy with CP transfusion and hydroxychloroquine for the first time. […] CP was intravenously given twice, and hydroxychloroquine was orally administrated for a week (0.2 g, three times a day). […] The lactic acid and C-reactive protein levels remained high (2.1 mmol/L and 73.23 mg/L, respectively), while the arterial oxyhemoglobin saturation decreased to 86% with a low oxygenation index (OI, 76 mmHg) on day 4 after CP transfusion. […] These findings suggested that the effectiveness of combination therapy with CP and hydroxychloroquine may be non-optimal, and specific therapy needs to be explored.
32562544 Among the 104 positive pairs, the mean difference in Cp value was 0.26 (range: 12.63 to -14.74), with an overall higher Cp value in NPsp (Pearson coefficient 0.579).
32593060 Biologically, two challenges need to be surmounted to allow convalescent plasma (CP) transfusion to rescue the most severe COVID-19 patients. […] Second, multi-criteria decision-making (MCDM) problems should be considered in the selection of the most suitable CP and the prioritisation of patients with COVID-19. […] This paper presents a rescue framework for the transfusion of the best CP to the most critical patients with COVID-19 on the basis of biological requirements by using machine learning and novel MCDM methods. […] In testing, ABO compatibility is assessed after classifying donors into the four blood types, namely, A, B, AB and O, to indicate the suitability and safety of plasma for administration in order to refine the CP tested list repository. […] Then, the patients with the most urgent need are classified into the four blood types and matched with a tested CP list from the test phase in the donor side. […] Thereafter, the prioritisation of CP tested list is performed using the contracted CP decision matrix. […] An intelligence-integrated concept is proposed to identify the most appropriate CP for corresponding prioritised patients with COVID-19 to help doctors hasten treatments.
32593519 On the base of historical experiences, Convalescent Plasma (CP), a passive antibody therapy, has been evaluated as a hopeful and potential therapeutic option since the beginning of the COVID-19 outbreak. […] In this scope competent authorities are responsible to set up certain principles and criteria for the collection and clinical use of COVID-19 Convalescent Plasma (CCP). […] The first part encompasses the supply of CCP and the second part lead the clinical use of CCP for the treatment of patients with severe COVID-19 infection. […] Turkish Ministry of Health developed a guide on collection and clinical use of CCP and created a web-based monitoring system to follow-up the patients treated with convalescent plasma in universal. […] This guide would be a pathfinder for clinicians and/or institutions those eager to conduct CCP treatment more effectively.
32620409 Convalescent Plasma (CP) therapy is of interest as no vaccine or specific treatment is available for emerging viruses such as severe acute respiratory syndrome coronavirus 2 causing Covid-19. […] It was aimed to report the results of our patients who underwent CP in the treatment of Covid-19. […] CP treatment was applied to 26 Covid-19 patients in intensive care unit who had quantitative reverse transcriptase-polymerase chain reaction positive Sars-Cov-2 infection. […] The collected CP (200cc) were applied to severe Covid-19 patients. […] Laboratory values of patients just before CP and after 7 days were compared. […] There were no statistically significant differences in leukocyte, neutrophil, lymphocyte, platelet, CRP, ferritin, LDH, ALT, AST, sO2 and total bilirubin values just before and after 1 week of CP. […] CP therapy has the potential to provide immediate and promising treatment options before specific vaccines and treatments are developed. […] In early stage Covid-19 patients who do not need mechanical ventilation, CP treatment may be a curative treatment option.
32627442 Although convalescent plasma (CP) therapy can be useful in the treatment of COVID-19, it has not been widely used in Korea because of the concerns about adverse effects and the difficulty in matching patients to donors. […] To overcome the obstacles of donor-recipient connections (schedule and distance), we propose the storage of frozen plasma, modification of the current Blood Management Law, and the establishment of a CP bank. […] We suggest that experience gained in CP therapy will be useful for not only the treatment of COVID-19, but also for coping with new emerging infectious diseases.
32634589 Convalescent plasma (CP) has been used successfully to treat many types of infectious disease, and has shown initial effects in the treatment of the emerging 2019 coronavirus disease (COVID-19). […] To explore the effectiveness of treatment and predict the potential effects of CP with COVID-19, studies of different types of infectious disease treated with CP were included in this systematic review and meta-analysis. […] The data quality was assessed, and the data were extracted and pooled for analysis. 40 studies on CP treatment for infectious diseases were included. […] Our study found that CP treatment could reduce the risk of mortality, with a low incidence of adverse events, promote the production of antibodies, lead to a decline in viral load, and shorten the disease course. […] A meta-analysis of 15 controlled studies showed that there was a significantly lower mortality rate in the group treated with CP (pooled OR=0.32; 95% CI=0.19-0.52; p<0.001, I2=54%) compared with the control groups. […] CP therapy has some curative effect and is well tolerated in treating infectious diseases.
32637086 In this report two severe cases of 2019 novel coronavirus disease (COVID-19) patients have been described who received convalescent plasma (CP). […] They started to improve with CP infusion both clinically and radiologically. […] CP might be an effective therapy for severe COVID-19 patients.
32643200 Therefore, in this review, we aim to point out some important issues related to convalescent plasma (CP) and its use in COVID-19. […] CP may be an adjunctive treatment option to the anti-viral therapy. […] The protective effect of CP may continue for weeks and months. […] Even though limited published studies are not prospective or randomized, until the development of vaccines or therapeutics, CP seems to be a safe and probably effective treatment for critically ill patients with COVID-19.
32659942 Although the air quality in the first week with fewer travels was in the excellent category, and chief pollutant (CP), as well as excessive pollutant (EP), were not found, as traffic volume increased, it became worse in the second and third weeks.
32670193 Implications for cerebral palsy (CP) children are that this will pose a challenge within this transformation. […] CP, as a discreet entity, is not considered a risk factor. […] However, specific comorbidities in individuals with CP, such as chronic lung disease, are known as COVID-19 risk factors. […] The overall risk for the CP population is probably a factor of age and comorbidities. […] Staying at home for CP children is both a challenge and an opportunity.
32678017 So, we infused the patient with convalescent plasma (CP), and the absolute lymphocyte count increased the next day and returned to normal on the fourth day. […] We note that the intravenous infusion of CP and MSCs for the treatment of severe COVID-19 patients may have synergistic characteristics in inhibiting cytokine storm, promoting the repair of lung injury, and recovering pulmonary function.
32684206 Currently there are no specific antiviral drugs and vaccines available for COVID-19, which has drawn the attention to the usefulness of convalescent plasma (CP) again, so the application of CP in the adult patients with COVID-19 is reviewed. […] The main contents include the possible mechanism of CP, the evidence of CP in the treatment of COVID-19 patients, the safety of clinical application of CP and the main factors affecting the clinical effect of CP, which may provide some basis for clinicians to choose CP for the treatment of adult patients with COVID-19.
32762746 Using a lateral flow assay (LFA) testing platform, the seropositivity in 63 New York Blood Center (NYBC) Convelescent Plasma (CP) donor samples were evaluated for the presence of COVID19 specific IgG and IgM. […] CP donors showed diverse antibody result. […] Weak antibody bands may identify low titer CP donors.
32770691 Recently, there have been several reports with inconsistent results after treatment with convalescent plasma (CP) on critically ill patients with COVID-19, which was produced with a neutralizing antibody titer and tested in a P3 or P4 laboratory. […] Here, we report the clinical courses of three critically ill patients with COVID-19 receiving CP treatments by total immunoglobulin G (IgG) titer collection. […] CP was collected by total IgG titer of 160 (range, 200-225 mL), and patients were transfused between 20 and 30 days after disease onset at the critical illness stage as a trial in addition to standard care. […] No therapeutic effect of CP was observed in any of the patients; instead, all three patients deteriorated and required extracorporeal membrane oxygenation treatment. […] A potential cytokine storm 4 hours after infusion of CP in Patient 2 was observed. […] No more patients were put on the trial of CP transfusion. […] We recommend extreme caution in using CP in critically ill patients more than 2 weeks after the onset of COVID-19 pneumonia.
32779705 Convalescent plasma (CP) is a potentially important therapy for coronavirus disease 2019 (COVID-19). […] We measured NAb titers in CP and in patients with acute COVID-19 before and after transfusion through the traditional Food and Drug Administration investigational new drug pathway. […] We performed a single-arm interventional trial measuring NAb and total antibody titers before and after CP transfusion over a 14-day period in hospitalized patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection. […] NAb titers in the donor CP units were low (<1:40 to 1:160) and had no effect on recipient neutralizing activity 1 day after transfusion. […] CP infusion did not alter recipient NAb titers. […] Prescreening of CP may be necessary for selecting donors with high titers of neutralizing activity for infusion into patients with COVID-19.
32792417 Convalescent plasma (CP) therapy has been used since the early 1900s to treat emerging infectious diseases; its efficacy was later associated with the evidence that polyclonal neutralizing antibodies can reduce the duration of viremia. […] Recent large outbreaks of viral diseases for which effective antivirals or vaccines are still lacking has renewed the interest in CP as a life-saving treatment. […] The ongoing COVID-19 pandemic has led to the scaling up of CP therapy to unprecedented levels. […] Compared with historical usage, pathogen reduction technologies have now added an extra layer of safety to the use of CP, and new manufacturing approaches are being explored. […] This review summarizes historical settings of application, with a focus on betacoronaviruses, and surveys current approaches for donor selection and CP collection, pooling technologies, pathogen inactivation systems, and banking of CP. […] We additionally list the ongoing registered clinical trials for CP throughout the world and discuss the trial results published thus far.
32802787 Convalescent plasma (CP) collected from patients recovered from the novel corona virus disease (COVID-19) has been considered as an effective treatment method for COVID-19. […] Given these considerations, we believe that a hybrid treatment including both CP and LDRT can trigger synergistic responses that will help healthcare providers in mitigating today’s COVID-19 pandemic.
32837984 Convalescent plasma (CP) therapy suggested its safety use in SARS-CoV-2 infection; but both CP immunotherapy and NK cellular therapy must be manufactured and utilized according to scrupulous ethical and controlled conditions to guarantee a possible role of these products of human origin.
32840002 Individuals who recovered from COVID-19 and volunteered to donate convalescent plasma (CP) were screened by NP swab PCR, responded to a questionnaire, and were tested for anti-COVID-19 antibodies. […] If anti-spike antibody is used to assess CP potency, individuals who suffered severe COVID-19 disease symptoms may represent better donors.
32850916 Historically, convalescent plasma (CP) has been utilized in the treatment of viral respiratory pathogens. […] Critically ill patients with COVID-19 in China and South Korea have been treated with CP given the ineffectiveness of experimental therapies with antivirals alone. […] This commentary explores the importance of published experience and the pending establishment of efficacy to facilitate an informed decision regarding the therapeutic use of CP.
32865701 Pulmonary imaging improvement was confirmed in 7 patients in early negative group and 8 in late negative group after CP therapy.
32879987 Scores ranging from 1 to 5 were assigned reflecting subjective assessment of image quality and related COVID-19 features, including ground glass opacities (GGO), crazy paving (CP), consolidation (CS), nodular infiltrates (NI), bronchovascular thickening (BVT), and pleural effusion (PE).
32885904 Convalescent plasma (CP) has demonstrated potential benefit in adults with SARS-CoV-2, but has theoretical risks.We present the first report of CP in children with life-threatening coronavirus disease 2019 (COVID-19), providing data on four pediatric patients with acute respiratory distress syndrome. […] We measured donor antibody levels and recipient antibody response prior to and following CP infusion. […] Infusion of CP was not associated with antibody-dependent enhancement (ADE) and did not suppress endogenous antibody response. […] We found CP was safe and possibly efficacious.
32898468 Convalescent plasma (CP) therapy is a type of adaptive immunity that has already been found to be effective in confronting several infectious diseases from the last two decades. […] For example, CP therapy was used in the treatment of viral-induced diseases like SARS-CoV epidemics, Middle East respiratory syndrome coronavirus (MERS-CoV) pandemics, Ebola epidemics and H1N1 pandemic. […] In this review, we have mainly focused on the therapeutic role of CP therapy and its neutralizing effect to fight against the COVID-19 outbreak.
32900666 Although, it has been reported to be an effective approach in various preliminary studies, convalescent plasma (CP) therapy has several limitations. […] In this mini review, an attempt has been made to review positive aspects, negative aspects and various limitations of the CP therapy for COVID-19 cases. […] The results of various studies show that CP therapy may be thought of one of the alternatives but while considering it as a therapeutic approach, in light of beneficial effects, the negative aspects and limitations are to be taken into consideration before its administration as a therapeutic agent.
32903199 Transfusion of convalescent plasma (CP) may provide passive immunity. […] The aim of this study is to test the feasibility, safety, and efficacy of CP in treating patients with COVID-19 across Saudi Arabia. […] Eligible patients with COVID-19 will be recruited for CP infusion according to the inclusion criteria. […] All CP recipients will receive supportive management including all available recommended therapies according to the available MOH guidelines. […] Eligible CP donors will be patients with COVID-19 who have fully recovered from their disease according to MOH recovery criteria as detailed in the inclusion criteria. […] CP donors have to qualify as blood donors according to MOH regulations except for the history of COVID-19 in the recent past. […] We will also test the CP donors for the presence of SARS-CoV-2 antibodies by a rapid test, and aliquots will be archived for future antibody titration. […] Due to the perceived benefit of CP, randomization was not considered. […] However, we will compare the outcome of the cohort treated with CP with those who did not receive CP due to a lack of consent or lack of availability. […] Hence, we plan to perform a propensity score matching of the CP recipients with the comparator group patients for the major characteristics. […] A total sample size of 575 patients, 115 CP recipients and 460 matched controls (1:4 ratio), will be sufficient to detect a clinically important hospital stay and 30-day mortality difference between the two groups with 80% power and a 5% level of significance. […] In this paper, we present a protocol for a national collaborative multicenter phase II study in Saudi Arabia for assessing the feasibility, safety, and potential efficacy of CP in treating patients with severe COVID-19. […] We plan to publish an interim report of the first 40 CP recipients and their matched comparators soon.
32905148 Therefore, we carried out an early systematic review to evaluate the efficacy of convalescent plasma (CP) therapy and its effects on COVID-19 patient outcomes.
32923991 We assessed outcome of patients with moderate and severe COVID-19 following treatment with convalescent plasma (CP) and the association with IgG levels in transfused CP. […] Antibody levels in CP units were unknown at the time of treatment. […] In 14/98 (14.3%) CP units IgG was < 1.1 (cutoff calibration) and in 60 (61.2%) ≤4.0. […] Treatment with CP with higher levels of IgG against S1 may benefit patients with moderate and severe COVID-19. […] IgG against S1 level in CP predicts neutralization antibodies titers.
32950044 Aim In this study, we aim to investigate the efficacy of convalescent plasma (CP) according to blood groups (BGs) in the treatment of critically ill patients diagnosed with COVID-19. […] Patients were divided into 2 groups as anti-A Antibody (Ab) containing (BG O and B) and those not containing anti-A Ab (BG A and AB) CP received patients. […] Results: Among 28 patients, 13 patients received anti-A Ab containing CP (BG; B: 6, O: 7), 15 patients not containing anti-A Ab CP (BG; A: 13, AB: 2). […] Duration in ICU, the rates of mechanical ventilation (MV) support and vasopressor support, the case fatality rate and discharge rate were lower in patients received CP containing anti-A Ab than not containing anti-A Ab CP. […] However, only the difference in the rate of MV support achieved statistically significance (p=0.04) Conclusion: In our study, it was observed that the efficiency of CP without anti-A antibody was lower than that of plasma containing anti-A antibody, although it was not statistically significant.
32958501 Convalescent plasma (CP) tended to increase the negative conversion rate (RR=2.47; 95% CI 1.70 to 3.57). […] Remdesivir and CP might be the potential treatments for patients with severe COVID-19.
32962613 Besides drugs and vaccines, the role of convalescent plasma (CP) therapy to treat COVID-19 is also discussed.
32965715 We retrospectively compared outcomes in a cohort of critical COVID-19 patients who received standard care (SC Group) and those who, in addition, received convalescent plasma (CP Group). […] The primary endpoint of improvement in respiratory support status within 28 days was achieved in 26 patients (65%) in the SC Group and 31 patients (77.5%) in the CP Group (p = .32).
33011076 In this study, we aim to investigate the efficacy of convalescent plasma (CP) in the treatment of severe and critically ill patients diagnosed with COVID-19. […] The data of severe or critically ill COVID-19 patients who received anti-SARS-CoV-2 antibody-containing CP along with the antiviral treatment (n = 888) and an age-gender, comorbidity, and other COVID-19 treatments matched severe or critically ill COVID-19 patients at 1:1 ratio (n = 888) were analyzed retrospectively. […] Duration in the intensive care unit (ICU), the rate of mechanical ventilation (MV) support and vasopressor support were lower in CP group compared with the control group (p = 0.001, p = 0.02, p = 0.001, respectively). […] The case fatality rate (CFR) was 24.7 % in the CP group, and it was 27.7 % in the control group. […] Administration of CP 20 days after the COVID-19 diagnosis or COVID-19 related symptoms were associated with a higher rate of MV support compared with the first 3 interval groups (≤5 days, 6-10 days, 11-15 days) (p=0.001). […] CP therapy seems to be effective for a better course of COVID-19 in severe and critically ill patients.
33014364 A possible solution is convalescent blood products (CBP), primarily convalescent plasma (CP) and immunoglobulins, as an adjunctive therapy.
33023671 Nose/throat swabs for determination of viral load are collected at day 0 and day 1 (before first CP administration) and subsequently at day 2, 3, 5, 7, 10, 14, 28 or until discharge.
33024082 Convalescent plasma (CP) transfusion has been indicated as a promising therapy in the treatment for other emerging viral infections. […] However, the quality control of CP and individual variation in patients in different studies make it rather difficult to evaluate the efficacy and risk of CP therapy for coronavirus disease 2019 (COVID-19). […] We aimed to explore the potential efficacy of CP therapy, and to assess the possible factors associated with its efficacy. […] Each patient was transfused with 200-400 mL of CP from seven recovered donors. […] The primary indicators for clinical efficacy assessment were the changes of clinical symptoms, laboratory parameters, and radiological image after CP transfusion. […] CP donors had a wide range of antibody levels measured by serology tests which were to some degree correlated with the neutralizing antibody (NAb) level. […] No adverse events were observed during and after CP transfusion. […] Following CP transfusion, six out of eight patients showed improved oxygen support status; chest CT indicated varying degrees of absorption of pulmonary lesions in six patients within 8 days; the viral load was decreased to a negative level in five patients who had the previous viremia; other laboratory parameters also tended to improve, including increased lymphocyte counts, decreased C-reactive protein, procalcitonin, and indicators for liver function. […] The clinical efficacy might be associated with CP transfusion time, transfused dose, and the NAb levels of CP. […] This study indicated that CP might be a potential therapy for severe patients with COVID-19.
33027056 The search string consisted of three domains: pain/CP (MeSH term) AND Peer group[MeSH] AND Videoconferencing[MeSH]/Telemedicine[MeSH]/Remote Consultation[MeSH].
33038227 The efficacy of convalescent plasma (CP) for the treatment of COVID-19 remains unclear. […] In a matched cohort analysis of hospitalized patients with severe COVID-19, the impact of CP treatment on in-hospital mortality was evaluated using univariate and multivariate Cox proportional-hazards models, and the impact of CP treatment on time to hospital discharge was assessed using a stratified log-rank analysis. 64 patients who received CP a median of 7 days after symptom onset were compared to a matched control group of 177 patients. […] The incidence of in-hospital mortality was 12.5% and 15.8% in the CP and control groups, respectively (p = 0.52). […] The overall rate of hospital discharge was not significantly different between the two groups (rate ratio [RR] 1.28, 95% CI 0.91 - 1.81), although there was a significantly increased rate of hospital discharge among patients 65-years-old or greater who received CP (RR 1.86, 95% CI 1.03 - 3.36). […] There was a greater than expected frequency of transfusion reactions in the CP group (2.8% reaction rate observed per unit transfused). […] We did not demonstrate a significant difference in risk of mortality or rate of hospital discharge between the CP and control groups. […] There was a signal for improved outcomes among the elderly, and further adequately powered randomized studies should target this subgroup when assessing the efficacy of CP treatment.
33060679 Impella CP is a percutaneously inserted left ventricular assist device indicated for temporary mechanical cardiac support during high risk percutaneous coronary interventions and for cardiogenic shock. […] Standard implantation of the Impella CP is performed under fluoroscopic guidance. […] Positioning of the Impella CP can be confirmed with transthoracic or transoesophageal echocardiography. […] We describe an alternative approach to guide intracardiac implantation of the Impella CP using two-dimensional and three-dimensional intracardiac echocardiography. […] Intracardiac three-dimensional echocardiography is a feasible alternative to the traditional techniques for implantation of an Impella CP device but careful consideration must be given to the potential limitations and complications of this technique.
33062267 Convalescent plasma (CP) therapy is a classic adaptive immunotherapy which has been in use for more a century to prevent and treat infections including SARS, Middle East respiratory syndrome (MERS), and H1N1 pandemic. […] Moreover, the World Health Organization regarded CP transfusion as the most promising therapy to treat MERS-CoV. […] This review was undertaken to demonstrate the potential of CP in the treatment of the pandemic COVID-19 disease. […] A total of eight studies conducted on CP therapy in patients with COVID-19 were reviewed wherein 25,028 patients above 18 years of age were involved. […] The vast majority of patients reported favorable outcomes when treated with CP with <1% serious adverse events. […] Despite its promising beneficial effects in patients severely ill with COVID-19, CP therapy requires further evaluation in randomized clinical trials (RCTs) as a lack of satisfactory efficacy data from this area certainly enhances the hesitancy with regard to employing this treatment. […] In the present circumstances of unsatisfactory pharmacological therapy and the urgent need for a successful curative remedy, considering the use of CP therapy is reasonable provided RCTs confirm its safety, efficacy, and tolerability.
33078604 Convalescent plasma (CP) was previously used successfully to treat SARS-CoV-1 and MERS infections. […] Forty consecutive patients who had received CP at our center were included in the study. […] Nine out of 10 patients who have received CP outside ICU have totally recovered from COVID-19 at a median of 9 days, and a half of the patients who needed invasive mechanical ventilation were successfully free of mechanical ventilation support and managed to recover from COVID-19. […] According to the results of this study, CP is an efficient conjunct to conventional therapy against COVID-19 with a favorable safety profile.
33101093 The COVID-19 crisis and subsequent stay-at-home orders have produced unprecedented challenges to the dissemination of recovery oriented behavioral health services (RS) that support the treatment of those with complex psychosis (CP). […] The telehealth conversion rates of the CP subsample indicated that 90% of CP patients accepted telehealth sessions and maintained their specific treatment plans in the virtual format. […] RSs play an essential role in the treatment of CP and telehealth may prove to be a viable format of care delivery even after the COVID-19 crisis subsides.
33104216 Recently, the Food and Drug Administration (FDA) issued emergency use authorization (EUA) of convalescent plasma (CP) for the treatment of COVID-19 hospitalized patients based on a non-peer reviewed open label observational study. […] Issuance of an EUA without a proven randomized control trial (RCT) sets a dangerous precedent since the premature action drives health care providers and patients away from RCTs that are essential for determining the efficacy and safety of CP.
33106167 General: To assess the safety, efficacy and dose response of convalescent plasma (CP) transfusion in severe COVID-19 patients Specific: a. […] To identify the appropriate effective dose of CP therapy in severe patients b. […] To assess the clinical improvement after CP transfusion in severe COVID-19 patients d. […] To assess the laboratory improvement after CP transfusion in severe COVID-19 patients TRIAL DESIGN: This is a multicentre, multi-arm phase II Randomised Controlled Trial. […] Patients who have recovered from COVID-19 will be recruited as donors of CP. […] This RCT consists of three arms, a. standard care, b. standard care and 200 ml CP and c. standard care and 400 ml CP.
33125158 Convalescent plasma (CP) for treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown preliminary signs of effectiveness in moderate to severely ill patients in reducing mortality. […] While studies have demonstrated a low risk of serious adverse events, the comprehensive incidence and nature of the spectrum of transfusion reactions to CP is unknown. […] We retrospectively examined 427 adult inpatient CP transfusions to determine incidence and types of reactions, as well as clinical parameters and risk factors associated with transfusion reactions. […] Our findings support the use of CP as a safe, therapeutic option from a transfusion reaction perspective, in the setting of COVID-19.
33136080 Respiratory dysfunction is a leading cause of morbidity and mortality in individuals with cerebral palsy (CP). […] In children and adults with CP, movement and physical function is always affected. […] Yet, many clinicians overlook potential for impaired movement and function of the diaphragm muscle (DIAm) in individuals with CP. […] Since individuals with pre-existing respiratory disorders are at greater risk for respiratory complications if they contract COVID-19, understanding potential risks to individuals with CP is important. […] In this review we present research on respiratory function and DIAm force generation in children with CP. […] We compare this clinical work to basic science research investigating phrenic motor neuron and DIAm motor unit dysfunction in an animal model with CP symptoms, the spa mouse. […] Finally, we integrate the clinical and basic science work in respiratory function in CP, discussing potential for individuals with CP to have severe respiratory symptoms from COVID-19.
33154232 Antivirals, immunisation, convalescent plasma (CP) and many more modalities are under trial, and there has been no definite answer to the management of COVID-19 infection. […] CP has been used to treat recent epidemic respiratory infections such as Middle East respiratory syndrome and severe acute respiratory syndrome (SARS) infections with promising results. […] The CP of a recovered individual contains antibodies which neutralise the virus and decrease the viral replication in the patient. […] CP is plasma taken from a person who has recovered from an infection, which contains neutralising antibodies against the said infection. […] Giving CP to susceptible individuals or infected patients is a form of passive antibody therapy and in the case of SARS-CoV-2, is expected to provide protection by viral neutralisation and antibody-dependent cytotoxicity and phagocytosis. […] Till date, randomised controlled studies for the use of CP in SARS-CoV-2 infection are lacking, and many countries have invited institutions to participate in clinical trials. […] The Indian Council of Medical research and the Central Drugs Standard Control Organisation, Government of India, have allowed the use of CP as an investigational drug under a trial basis. […] Internationally, agencies such as the USFDA, American Association of Blood Banks, European Blood Safety and British Blood Transfusion Society have also come out with various guidelines for the use of CP in COVID-19 infection. […] This article will review the current guidelines for the use of CP and compare the various guidelines of different agencies.
33157180 The following rates of HAI were compared pre- and postpandemic: health care-associated respiratory-viral-infection (HA-RVI), methicillin-resistant Staphylococcus aureus, and CP-CRE acquisition rates, health care-facility-associated C difficile infections and device-associated HAIs. […] Despite the disruption caused by the pandemic, there was no increase in CP-CRE acquisition, and rates of other HAIs remained stable.
33157287 The therapeutic options have been explored either against hyperinflammation from dysregulated adaptive immunity or direct virus neutralization using antibodies from convalescent plasma (CP) of a recovered patient. […] We undertook this exploratory study to evaluate safety and efficacy of TPE followed by CP transfusion in 14 patients with critical COVID-19 requiring invasive mechanical ventilation (IMV). […] This case series demonstrated the sequential use of TPE followed by CP transfusion as a therapeutic option in critical COVID-19.
33157910 Some doctors are using convalescent plasma (CP) therapies to treat COVID-19 patients. […] However, whether CP therapy is effective for children with COVID-19 remains controversial. […] Therefore, this study further explores the effectiveness and safety of human coronavirus immune CP in the treatment of COVID-19 in children. […] This study will provide high-quality comprehensive evidence for the effectiveness and safety of human coronavirus immuno CP in the treatment of COVID-19 in children CONCLUSIONS:: The results of this study will provide the basis for the effectiveness and safety of human coronavirus immuno CP treatment of COVID-19 in children.
33167389 In the lack of an effective vaccine and antiviral treatment, convalescent plasma (CP) has been a promising therapeutic approach in past pandemics. […] Accumulating evidence in the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic corroborates the safety of CP therapy and preliminary data underline the potential efficacy. […] Recently, the Food and Drug Administration (FDA) permitted CP therapy for coronavirus disease 2019 (COVID-19) patients under the emergency use authorization, albeit additional clinical studies are still needed. […] The imminent threat of a second or even multiple waves of COVID-19 has compelled health authorities to delineate and calibrate a feasible preparedness algorithm for deploying CP as an immediate therapeutic intervention. […] In this review, we evaluate the current status of CP therapy for COVID-19 patients and address the challenges that confront the implementation of CP.
33169114 High expectations have been set around convalescent plasma (CP) for the treatment of COVID-19. […] Herein we report that RCTs of CP disclose a high methodological variability in inclusion criteria, outcomes, appropriate selection of donors, dosage, concentration of neutralizing antibodies and times of transfusion. […] Therefore, at this time there is insufficient evidence to recommend for or against the use of CP as a treatment for COVID-19.
33202419 Convalescent plasma (CP) from blood donors with anti-SARS-CoV-2 antibodies may benefit patients with COVID-19 by providing immediate passive immunity via transfusion, or when used to manufacture hyperimmune immunoglobulin preparations. […] Preliminary safety data for COVID-19 CP are encouraging, but establishing the clinical efficacy of CP requires recruitment of patients to high-quality randomized trials and an ongoing international collaborative effort.
33204428 Several studies of individuals with severe COVID-19 regard convalescent plasma (CP) transfusion as an effective therapy. […] However, no significant improvements are found in randomized clinical trials of CP treatment. […] Until now, data for individuals with mild COVID-19 transfused CP were lacking. […] This study recruited eight individuals with mild COVID-19 who received at least one dose of CP transfusion. […] After CP therapy, the clinical symptoms of all individuals improved. […] The median time for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid test to become negative was 2.5 days after CP transfusion. […] The study shows the potential benefits of CP. […] Meanwhile, CP probably enhances the inflammatory response to SARS-CoV-2 temporarily in people with insufficient antiviral immunity. […] However, the effects of CP are not permanent.
33208301 Chronic pain (CP) and cognitive decline (CD) are costly, challenging to treat, prevalent among older adults, and worsen each other over time. […] We are iteratively developing Active Brains-Fitbit (AB-F), a live video program for older adults with CP and CD that teaches mind-body skills and gradual increases in step count. […] We are conducting a feasibility randomized controlled trial (RCT) of AB-F versus a time- and dose-matched educational control (health enhancement program [HEP]) in older adults with CP and CD. […] This study will answer important questions about the feasibility of delivering a completely virtual mind-body activity program to older adults with comorbid CP and CD, which, to our knowledge, is unprecedented. […] Details on integrating multiple digital platforms for virtual assessments and intervention delivery will inform treatment development for older adults and those with comorbid CP and CD, which is crucial during the COVID-19 pandemic.
33231313 Six critically ill COVID-19 patients with plasma viscosity levels ranging from 2.6 to 4.2 centipoise (cP; normal range, 1.4-1.8 cP) underwent daily TPE for 2-3 treatments. […] TPE decreased plasma viscosity in all six patients (Pre-TPE median 3.75 cP, range 2.6-4.2 cP; Post-TPE median 1.6 cP, range 1.5-1.9 cP).
33231325 Although many trials are currently investigating the safety and efficacy of convalescent plasma (CP) in critically ill COVID-19 patients, there is a paucity of ongoing and published studies evaluating the CP donors’ side. […] This retrospective study reports the first Italian experience on CP donors’ selection and donations. […] Eighty-five percent (437/512) of the CP donors were males. […] The average time between symptom recovery and CP donation was 36.6 (±20.0) days. […] Ninety-three percent (460/494) of CP donors at the time of plasma donation had a neutralizing IgG titer ≥1:80. […] This study demonstrates the feasibility and safety of a pilot CP program conducted in Italy. […] The identification of factors (ie, age and severity of COVID-19) positively associated with higher neutralizing antibody titers at the time of donation may help to optimize the selection of CP donors.
33233035 Townsend and colleagues highlighted the myriad political forces which fostered attention to health issues during negotiations to establish a new trans-pacific trade deal in Australia (the CP-TPP [Comprehensive and Progressive Agreement for Trans-Pacific Partnership], formerly known as TPP).
33242674 Here we report on seven intensive care unit (ICU) patients with coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS) who developed positive rectal swabs and invasive infections due to carbapenemase-producing Klebsiella pneumoniae (CP-Kp). […] Notwithstanding the infection prevention measures introduced during the COVID-19 pandemic and changes in the hospitalised population, attention to CP-Kp infections must remain high, especially in the critically ill setting.
33254633 from NCP to CP. […] The higher levels of ozone at both PD and DSL on CP might be due to the weak nitrogen monoxide titration, low relative humidity and high visibility compared with NCP. […] Therefore, the decreasing regional transported air pollutants coincided with the emission control of local sources to cause the abatement of haze-fog events in YRD region on CP.
33285298 The use of ancient immunotherapeutic technique - the convalescent plasma (CP) therapy, may act as an immediate and available option to control the COVID-19 pandemic. […] This review provides a concept and understanding on the CP therapy, its potential to control SARS-CoV-2 pandemic. […] The CP therapy might act as an immediate saviour for society from the virus. […] Although the CP therapy has exert affirmative result against COVID-19 it has not been recommended for long time use in COVID-19 and this review gives support for its possible application.
33285550 Our aim was to retrospectively investigate the use of LUS in the ED to identify COVID-19 pneumonia (CP). […] A total of 41% patients were COVID-19-positive; 67% of them were diagnosed with CP. […] The ROC curve of the LUS score showed an area under the curve of 0.837 (95% CI 0.75-0.92) and with a cutoff value ≥3 identified 28 of 31 patients with CP and 11 of 15 without (sensitivity 90%, 95% CI 74-97%; specificity 75%, 95% CI 56-76%). […] LUS is a promising technique for early identification of CP in patients who accessed the ED in an active epidemic time. […] The LUS score shows a sensitivity of 90% for CP, allowing to quickly direct patients with COVID-19 to the ED isolation area or to discharge them for outpatient treatment.
33297703 One of the available treatment alternatives for COVID-19 is the administration of convalescent plasma (CP), blood plasma obtained from people who have undergone the disease. […] CP can also be used for production a specific immunoglobulin. […] Experience from previous epidemic infections, caused by the coronaviruses SARS-CoV-1 and MERS-CoV, shows that CP contains neutralizing antibodies against the virus, which are probably the main source of its therapeutic potential. […] The use of CP for the treatment of COVID-19 spread during the first half of year 2020 in many countries worldwide and relatively common is also in the Czech Republic, where, at the end of August 2020, about 100 patients were treated with CP. […] The production and use of CP is governed by the national multidisciplinary guidelines from April 2020 and the recommended therapeutic dose are 2 TU RP (400-450 mL), resp. 4-6 mL/kg. […] CP is indicated mainly in severe cases of COVID-19, which require oxygen support, ideally within 2-3 days after diagnosis, but our and foreign experience shows a beneficial effect of CP even in moderately severe cases that do not need oxygen treatment.
33313733 Given access barriers to cognitive behavioral therapy for chronic pain (CBT-CP), this pragmatic superiority trial will determine whether a remotely delivered CBT-CP intervention that addresses these barriers outperforms in-person and other synchronous forms of CBT-CP for veterans with musculoskeletal pain. […] This pragmatic trial compares an asynchronous form of CBT-CP that uses interactive voice response (IVR) to allow patients to participate from their home (IVR CBT-CP) with synchronous CBT-CP delivered by a Department of Veterans Affairs (VA) clinician. […] This pragmatic trial compares the outcomes, cost, and implementation of two forms of CBT-CP as delivered in the real-world setting.
33323550 However, a vaccine or specific drug is absent up to this date and more attention has been focused on the use of convalescent plasma (CP). […] Several articles have described the CP treatment for patients with SARS-CoV-2 infection. […] But a comprehensive systematic review with meta-analysis about the safety and efficacy of CP transfusion in SARS-CoV-2-infected patients has not been published. […] We conducted this study for a better understanding of the therapeutic significance of CP for patients with COVID-19. […] =0.0%) was used on the 9 articles for quantitative analysis showing that the mortality of patients with COVID-19 treated with or without CP was statistically significant (RR=0.57 [0.44-0.74]). […] Subgroup analysis showed that the severely ill patients benefited more from CP than the critically ill patients.
33323600 To analyze the impact of ophthalmic webinars on the resident’s learning experience during the COVID-19 pandemic (CP). […] This cross-sectional nationwide study was carried out for 1 month during CP and included a total of 382 ophthalmic residents. […] Residents expressed a decline in their clinical exposure (74%; 220), thesis work (58%; 218), and acquisition of the knowledge and skills (42.5%; 161) during CP. […] Nearly 75% (291) of residents endorsed webinars as good to the very good academic tool, and 54% (202) preferred to continue attending webinars in the post-CP phase.
33338863 Convalescent plasma(CP) immunotherapy was an effective method for fighting against similar viral infections such as SARS-CoV, and MERS-CoV. […] In the epidemic of COVID-19, a large number of literatures reported the application of CP. […] However, there is controversy over the efficacy of CP therapy for COVID-19. […] This systematic review was designed to evaluate the existing evidence and experience related to CP immunotherapy for COVID-19. […] Second, limited safety data suggested that CP is a well-tolerated therapy with a low incidence of adverse events. […] But, due to lack of safety data for the control group, it is really not easy to determine whether CP transfusion has an impact on moderate to serious AEs. […] Thirdly, for children, pregnant, elderly, tumor and immunocompromised patients, CP may be a well-tolerated therapy, if the disease cannot be controlled and continues to progress. […] Although the results of limited RCTs showed that CP cannot significantly reduce mortality, some non-RCTs and case report(series) have found that CP may help patients improve clinical symptoms, clear the virus, and reduce mortality, especially for patients with COVID-19 within ten days of illness. […] We speculate that CP may be a possible treatment option. […] High-quality studies are needed for establishing stronger quality of evidence and pharmacists should also be actively involved in the CP treatment process and provide close pharmaceutical care.
33350298 Spasticity is the most common motor disturbance in cerebral palsy (CP). […] This consensus report includes BoNT injection recommendations in the management of spasticity during the COVID-19 pandemic in children with CP. […] BoNT injections can be administered to children with CP with appropriate indications and with necessary precautions during the pandemic.
33356684 The rational practice of CP therapy guided by risk-benefit judgment from aspects of donor and recipient can be a therapeutic option in such a global health crisis.
33375675 A longer follow-up of CP donors will eventually reveal the time needed for full recovery of their immune system competence.
33384519 Nine trials on hydroxychloroquine (HCQ), six studies on antiviral, four studies on monoclonal antibodies, two on corticosteroids, two on convalescent plasma (CP), and one on interferon-α2b were included in the systematic review. […] Two small case series on CP showed some promising results. […] The study showed slightly favorable results with HCQ, monoclonal antibodies, remdesivir, and CP in treating COVID-19 patients.
33399343 Aim of our study was to assess the association between COVID-19 lockdown and cardiac pacing (CP) procedures rates in Campania Region, the third-most-populous region of Italy with about 5.8 million residents. […] Data about type of CP procedures and unit admissions were obtained from 14 CP centers throughout Campania region from March 10th and May 4Th 2020 and compared with the same time frame in 2019. […] COVID-19 lockdown was associated with a remarkable decrease in CP procedures due to the reduction of planned hospitalizations in Campania Region; however, no significant difference in emergency department admission rate was shown.
33402882 To investigate clinical efficacy and safety of convalescent plasma (CP) therapy in coronavirus disease 2019 (COVID-19) patients. […] CP therapy for COVID-19 was effective and safe. […] Three patients who did not combine with antiviral therapy after CP also obtained viral clearance and clinical improvement. […] However, CP therapy failed to save the life of a terminally ill patient.
33405026 We examined associations between parental exposures to COVID-19, parental worries about the pandemic, harsh and warm parenting practices, and child CP and CU traits. […] Although more parental worries were not directly related to parenting practices, more worry about COVID-19 was specifically related to higher levels of child CP, particularly parental worries about themselves or family members contracting the virus.
33428990 Cycle of positivity (Cp) and categorical agreement was compared in samples tested in standard rRT-PCR after NA purification and in in-well lysis, direct rRT-PCR.
33448402 There are limited data on the neutralizing activity of convalescent plasma (CP) administered in randomized controlled trials (RCT) of COVID-19 infection. ) on a human immunodeficiency virus 1 vector (NL43dEnvNanoLuc), using ACE2-expressing 293T cells. […] The titer needed to neutralize 50% of viral activity (NT50) was calculated. cells was inhibited by pretreatment with CP compared to control CP (p<0.001) with control plasma having a median (IQR) 50% neutralization titer (NT50) of 1:28 (1:16,1:36) compared to 1:334 (1:130,1:1295) and 1:324 (1:244,1:578), for medium anti-NP and high anti-NP CP units, respectively. […] The neutralizing activity of CP met minimum FDA criteria with neutralizing antibody titers >1:80 in 100% of randomly selected samples, using a conservative approach that excluded non-specific binding. […] Plasma from donors screened using an immunochromatographic test for IgG antibody to SARS-CoV-2 NP exhibited neutralizing activity meeting FDA’s minimum standard in all randomly selected COVID-19 CP units.
33472681 It has long been hypothesized that the use of convalescent plasma (CP) from infected patients who have developed an effective immune response is likely to be an option for the treatment of patients with a variety of severe acute respiratory infections (SARI) of viral etiology. […] Subjects are randomly assigned in a 1:1 ratio (139 per treatment arm), stratified by center, to receive intravenously administered CP (single infusion) plus SOC or SOC alone, and are to be followed for 30 days. […] The results of this study are expected to contribute to establishing the potential place of CP in the therapeutics for a new viral disease.
33491194 The efficacy of convalescent plasma (CP), an alternative for the treatment of COVID-19, depends on high titers of neutralizing antibodies (nAbs), but assays for quantifying nAbs are not widely available. […] Our goal was to develop a strategy to predict high titers of nAbs based on the results of anti-SARS-CoV-2 immunoassays and the clinical characteristics of CP donors. […] A total of 214 CP donors were enrolled and tested for the presence of anti-SARS-CoV-2 antibodies (IgG) using two commercial immunoassays: EUROIMMUN (ELISA) and Abbott (Chemiluminescence). […] Regarding the studied criteria for identifying CP donors with high nAbs titers: (a) C1 showed 76.1% accuracy if S/CO = 4.65, (b) C2 presented 76.1% accuracy if S/CO ≥4.57 and (c) C3 had 71.6% accuracy if S/CO was ≥4.57 or if S/CO was between 2.68-4.57 and the last COVID-19-related symptoms were recent (within 19 days).
33492637 Convalescent plasma (CP) therapy is rapidly becoming an established consideration in the treatment of COVID-19 patients though there is a need to critically review this area for proof of efficacy. […] Neutralizing antibodies (NAb) present in CP generated in response to SARS-CoV-2 infection directed against the receptor-binding domain (RBD) of the spike protein are considered to play main role in viral clearance. […] CP infusion may also help in the modulation of immune response by its immunomodulatory effect. […] The FDA allows for administration of CP to COVID-19 patients. […] Though multiple uncertainties exist regarding to its efficacy, appropriate donor selection and NAb titres, the efficacy data of CP use inCOVID-19 is limited having shown hope with early and severe to critically ill COVID-19 patients.
33518427 Among anti-viral agents, convalescent plasma (CP) from recovered patients is the object of intense research following the first positive reports in severe COVID-19 patients. […] The aim of this narrative review will be to critically discuss the literature evidence on CP use in these categories of patients.
33519339 To present the interim findings from a national study investigating the safety and efficacy of convalescent plasma (CP) containing detectable IgG antibodies as a treatment strategy for severe coronavirus disease 2019 (COVID-19). , ≤93%, PaO2/FiO2 ratio, <300; and/or lung infiltrates >50% within 24-48 h), (b) requiring intensive care unit (ICU) care or (c) experiencing life-threatening conditions. […] The control group included confirmed severe COVID-19 patients of similar characteristics who did not consent for CP infusion or were not able to receive CP due to its nonavailability. […] The intervention group participants were infused 300 ml (200-400 ml/treatment dose) CP at least once, and if required, daily for up to 5 sessions, along with receiving the best standard of care. […] CP containing detectable antibodies is a safe strategy and may result in a decrease in mortality in patients with severe COVID-19.
33521696 However, analysis of additional CP units revealed widely varying NAb titers, with many recipients exhibiting endogenous NAb responses far exceeding those of the administered units. […] To obtain the full therapeutic benefits of CP immunotherapy, it will thus be important to determine the neutralizing activity in both CP units and transfusion candidates.
33527424 Antiviral treatment with convalescent plasma (CP) could be an alternative treatment option. […] In this case report, we present two kidney transplant recipients and two hemodialysis patients who were infected with SARS-CoV-2 and received CP. […] After CP treatment, we observed an increase of SARS-CoV-2-specific antibodies (IgG ratio and neutralization titer) and of specific cellular responses. […] After intermittent clinical improvement, one kidney transplant recipient again developed typical symptoms on Day 12 after treatment and received a second cycle of CP treatment. […] Our data suggest that the success of CP therapy may only be temporary in patients with chronic kidney disease; which requires close monitoring of viral load and antiviral immunity and possibly an adaptation of the treatment regimen.
33533733 Convalescent plasma (CP) therapy is one of the promising therapies being tried for COVID-19 patients. […] Various CP therapy parameters such as donor selection, antibody quantification, timing of use, and dosing need to be considered before its use. […] The current review attempts to summarize the available evidence and provide recommendations for setting up CP protocols in clinical and research settings.
33539280 To support the health system, several activities have been promoted: large-scale convalescent plasma (CP) production, clinical trials with CP and mesenchymal stromal cells, massive COVID-19 diagnoses, and participation in co-operative research and publications.
33576494 Heterologous polyclonal antibodies might represent an alternative to the use of convalescent plasma (CP) or monoclonal antibodies (mAbs) in COVID-19 by targeting multiple antigen epitopes.
33582019 The present study was designed to evaluate the safety and efficacy of convalescent plasma (CP) for treating severe cases of COVID-19 who developed acute respiratory distress syndrome (ARDS). […] Among 64 confirmed cases of severe COVID-19 with ARDS in this study, 32 patients received CP besides first line treatment. […] Their clinical response and outcome in regard to disease severity and mortality rate were evaluated and compared with the other 32 patients in the control group who were historically matched while randomly chosen from previous patients with the same conditions except for receiving CP therapy.
33588962 In this manuscript, we discuss the implementation and deployment of mobile integrated health/community paramedicine (MIH/CP) testing sites to provide screening, testing and community outreach during the first months of the coronavirus 2019 (COVID-19) pandemic in the metropolitan region of Charlotte, North Carolina, USA. […] This is a descriptive report of the implementation of MIH/CP test sites in our healthcare system’s early response to the COVID-19 pandemic in March 2020. […] Between March 15, 2020 and April 15, 2020, our six MIH/CP test sites evaluated 4342 patients. […] There were no cases of accidental exposure or failure of PPE for the MIH/CP paramedics. […] In our healthcare system, we pivoted the traditional MIH/CP model to rapidly initiate remote drive-through testing for COVID-19 in pre-screened individuals.