CDKN1C


cyclin dependent kinase inhibitor 1C


ENTREZID: 1028 | Type: Protein Coding | Map: 11p15.4

OMIM: 616737 | 116952


Summary Entrez
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]