pentraxin 3

Gene Context Sentence

Table 2. Analysis of context sentence of PTX3 gene in 2 abstracts.

PMID Gene Context Sentence
33208929 RNA-sequencing analysis of peripheral blood mononuclear cells, single-cell bioinformatics analysis and immunohistochemistry of lung autopsy samples revealed that myelomonocytic cells and endothelial cells express high levels of PTX3 in patients with COVID-19. […] Increased plasma concentrations of PTX3 were detected in 96 patients with COVID-19. […] PTX3 emerged as a strong independent predictor of 28-d mortality in multivariable analysis, better than conventional markers of inflammation, in hospitalized patients with COVID-19. […] The prognostic significance of PTX3 abundance for mortality was confirmed in a second independent cohort (54 patients). […] Thus, circulating and lung myelomonocytic cells and endothelial cells are a major source of PTX3, and PTX3 plasma concentration can serve as an independent strong prognostic indicator of short-term mortality in COVID-19.
33489054 Pentraxin-3(PTX3) participates in innate resistance to infections and plays a role in thrombogenesis. […] The present study aimed to investigate the role of PTX3 in coagulopathy in patients with COVID-19. […] Serum PTX3 levels were detected by enzyme-linked immunosorbent assays and compared between those two groups, then receiver operating characteristic (ROC) curve analysis, correlation analysis, and linear regression models were performed to analyze the association between PTX3 and D-dimer. […] Serum level of PTX3 was positively correlated with disease severity and coagulopathy. […] Detection of serum PTX3 level could help identify severer patients on admission and may be a potential therapeutic target for coagulopathy in patients with COVID-19.