RIPK1


receptor interacting serine/threonine kinase 1


ENTREZID: 8737 | Type: Protein Coding | Map: 6p25.2

OMIM: 613889


Summary Entrez
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017]