toll like receptor 7
Gene Context Sentence
Table 2. Analysis of context sentence of TLR7 gene in 3 abstracts.
|PMID||Gene Context Sentence|
|32253888||The levels of activation of the immune cells are higher in women than in men, and it is correlated with the trigger of TLR7 and the production of IFN. […] TLR7 is higher in women than in men and its biallelic expression leads to higher immune responses and increases the resistance to viral infections. […] TLR7 is expressed in innate immune cells which recognizes single strand RNA virus by promoting the production of antibodies against the virus and the generation of pro-inflammatory cytokines including IL-6 and IL-1 family members.|
|32361001||TLR7/8 can identify the single-stranded RNA (ssRNA) of the virus. […] This study aimed to search ssRNA sequences recognized by TLR7/8 from the SARS-CoV-2, SARS-CoV, and MERS-CoV whole genomes by a bioinformatic technique. […] The immunoinformatic approach showed that the SARS-CoV-2 genome has more ssRNA fragments that could be recognized by TLR7/8 than the SARS-CoV genome. […] This activity is possibly able to provoke a robust proinflammatory response via TLR7/8 recognition and cause acute lung injury.|
|32456409||Conti and Younes have pointed to a connection between lower TLR7 expression in men and their increased vulnerability towards a severe form of COVID-19 infection (1). […] I had started to investigate the same idea and think that I have discovered a wealth of additional supporting information that renders the hypothesis plausible and, if correct, could establish lower TLR7 activity/sensitivity as a common molecular characteristic of several high-risk patient groups.|