toll like receptor 7

Gene Context Sentence

Table 2. Analysis of context sentence of TLR7 gene in 3 abstracts.

PMID Gene Context Sentence
32253888 The levels of activation of the immune cells are higher in women than in men, and it is correlated with the trigger of TLR7 and the production of IFN. […] TLR7 is higher in women than in men and its biallelic expression leads to higher immune responses and increases the resistance to viral infections. […] TLR7 is expressed in innate immune cells which recognizes single strand RNA virus by promoting the production of antibodies against the virus and the generation of pro-inflammatory cytokines including IL-6 and IL-1 family members.
32361001 TLR7/8 can identify the single-stranded RNA (ssRNA) of the virus. […] This study aimed to search ssRNA sequences recognized by TLR7/8 from the SARS-CoV-2, SARS-CoV, and MERS-CoV whole genomes by a bioinformatic technique. […] The immunoinformatic approach showed that the SARS-CoV-2 genome has more ssRNA fragments that could be recognized by TLR7/8 than the SARS-CoV genome. […] This activity is possibly able to provoke a robust proinflammatory response via TLR7/8 recognition and cause acute lung injury.
32456409 Conti and Younes have pointed to a connection between lower TLR7 expression in men and their increased vulnerability towards a severe form of COVID-19 infection (1). […] I had started to investigate the same idea and think that I have discovered a wealth of additional supporting information that renders the hypothesis plausible and, if correct, could establish lower TLR7 activity/sensitivity as a common molecular characteristic of several high-risk patient groups.