APOL1

apolipoprotein L1

Gene Context Sentence


Table 2. Analysis of context sentence of APOL1 gene in 12 abstracts.

PMID Gene Context Sentence
32561682 Previous research linked increased susceptibility to collapsing glomerulopathy, including in patients with HIV-associated nephropathy, to apo L1 (APOL1) variants that are more common in those of African descent. […] We also collected peripheral blood for APOL1 genotyping. […] All six patients had an APOL1 high-risk genotype. […] Collapsing glomerulopathy in black patients with COVID-19 was associated with high-risk APOL1 variants.
32563685 While APOL1 has been theorized in the epidemiology of hypertension, the increased prevalence and associated risks are primarily due to environmental and lifestyle factors.
32668317 Genotyping for the 2 risk alleles of the apolipoprotein L1 (APOL1) gene revealed that the donor carried the low-risk G0/G2 genotype. […] This case illustrates that coronavirus disease 2019 infection may promote a collapsing glomerulopathy in kidney allografts with a low-risk APOL1 genotype in the absence of detectable SARS-CoV-2 RNA in the kidney and that podocyte injury may precede SARS-CoV-2 RNAemia.
32680910 Genotyping of three patients with collapsing glomerulopathy and the patient with minimal change disease revealed that all four patients had APOL1 high-risk gene variants.
32775989 Both patients were homozygous for apolipoprotein L1 (APOL1). […] APOL1 testing should be strongly considered in African American patients with nephrotic-range proteinuria.
32775990 The presence of the apolipoprotein L1 (APOL1) high-risk genotype is a major risk factor for collapsing glomerulopathy in African Americans. […] Both patients had the APOL1 high-risk genotype. […] We propose that collapsing glomerulopathy represents a novel manifestation of COVID-19 infection, especially in people of African descent with APOL1 risk alleles.
32852403 Genotyping for 2 risk alleles of the apolipoprotein L1 (APOL1) gene demonstrated that the donor was homozygous for the G2/G2 genotype. […] In renal transplant patients receiving kidneys from donors with high-risk APOL1 variants, COVID-19 may promote acute glomerular injury in the form of focal and segmental glomerulosclerosis.
32972761 Apolipoprotein L1 (APOL1) genetic testing confirmed 2 high-risk APOL1 alleles in the kidney donor. […] We speculate that COVID-19-induced systemic or local cytokine release could serve as a second hit in the presence of APOL1 risk alleles and mediate a podocytopathy manifesting as nephrotic syndrome. […] The presented case with minimal change-like disease, occurring in the context of the donor high-risk APOL1 genotype, extends the spectrum of clinical manifestations in COVID-19-associated nephropathy.
33195337 For the patients diagnosed with Collapsing Glomerulopathy, peripheral blood will be collected for apolipoprotein L-1 (APOL1) genotyping.
33214201 Previous patient reports have described patients of African ancestry who developed nephrotic-range proteinuria and AKI early in the course of disease. genotype analysis of one of the native biopsies and the donor kidney graft. genotype; this contradicts current models of APOL1-mediated kidney injury, and suggests that intrinsic renal expression of APOL1 may not be the driver of nephrotoxicity and specifically, of podocyte injury. genotype.
33354883 The 14 patients assessed had an APOL1 high-risk genotype. […] The 16 cases detailed in the present report strongly argue in favour of a causal link between SARS-CoV-2 infection and the occurrence of CG in patients homozygous for APOL1 high-risk genotype for which the term COVID-associated nephropathy (COVIDAN) can be put forward.
33576823 Acute tubular injury occurred almost invariably in the setting of severe forms of COVID-19, whereas patients with glomerular injury had various profiles of COVID-19 severity and collapsing glomerulopathy was only observed in patients harboring a combination of APOL1 risk variants. […] While acute tubular injury is correlated with COVID-19 severity, the pattern of glomerular injury is intimately associated with the expression of APOL1 risk variants.