NLR family member X1
Gene Context Sentence
Table 2. Analysis of context sentence of NLRX1 gene in 1 abstracts.
|PMID||Gene Context Sentence|
|33314068||NLRX1 is a member of the NOD-like receptor family, a set of pattern recognition receptors associated with innate immunity. […] Interestingly, NLRX1 exists in somewhat of an exile from its NLR counterparts with unique features that mediate atypical functions compared with traditional NOD-like receptors (NLRs). […] Mitochondrially located, NLRX1 sits within a subgroup of regulatory NLRs responsible for negatively regulating cellular inflammatory signalling. […] As well as modulating pathogen response, emerging evidence is implicating NLRX1 as a central homeostatic gatekeeper between mitochondrial biology and immunological response. […] More recently, NLRX1 has been implicated in a wide range of disease, both pathogen-driven and otherwise. […] Emerging links of NLRX1 in cancer biology, autoimmunity and other inflammatory conditions are raising the potential of targeting NLRX1 therapeutically, with recent studies in inflammatory bowel disease showing great promise. […] Within this review, we address the unique features of NLRX1, its roles in innate immune signalling and its involvement in a range of inflammatory, metabolic and oncology disease indications with a focus on areas that could benefit from therapeutic targeting of NLRX1.|