SCD

stearoyl-CoA desaturase

Gene Context Sentence


Table 2. Analysis of context sentence of SCD gene in 27 abstracts.

PMID Gene Context Sentence
32369606 During the COVID-19 pandemic, patients with sickle cell disease (SCD) have been included in the “high risk” group of the population.
32420608 Concern has been raised on sickle cell disease (SCD) patients and the new viral infection with SARS-COV-2 since SCD patients are particularly prone to infectious diseases and acute chest syndrome (ACS).
32589774 Sickle Cell Disease (SCD) disproportionately affect Black/African Americans in the United States as well as forebearers from sub-Saharan Africa, the Western Hemisphere (South America, the Caribbean, and Central America) and some Mediterranean countries. […] The carrier frequency for SCD is high amongst African Americans.
32639228 Sickle cell disease (SCD) disproportionately affects Black or African American persons in the United States and can cause multisystem organ damage and reduced lifespan. […] Among 178 persons with SCD in the United States who were reported to an SCD-coronavirus disease case registry, 122 (69%) were hospitalized and 13 (7%) died.
32670524 This study aims to investigate, retrospectively, the epidemiological and clinical characteristics, laboratory results, radiologic findings, and outcomes of COVID-19 in patients with transfusion-dependent β thalassemia major (TM), β-thalassemia intermedia (TI) and sickle cell disease (SCD). […] A total of 13 patients, 7 with TM, 3 with TI, and 3 with SCD, with confirmed COVID-19, were identified in 6 Centers from different countries. […] Increased C-reactive protein (6/10), high serum lactate dehydrogenase (LDH; 6/10), and erythrocyte sedimentation rate (ESR; 6/10) were the most common laboratory findings. 6/10 patients had an exacerbation of anemia (2 with SCD). […] In one Center (Oman), the majority of suspected cases were observed in patients with SCD between the age of 21 and 40 years. […] A rapid clinical improvement of tachypnea/dyspnea and oxygen saturation was observed, after red blood cell exchange transfusion, in a young girl with SCD and worsening of anemia (Hb level from 9.2 g/dl to 6.1g/dl).
32701630 We report the emergency use of immunomodulatory therapy utilizing an extracorporeal selective cytopheretic device (SCD) in two patients with elevated serum interleukin (IL)-6 levels and refractory COVID-19 ARDS requiring extracorporeal membrane oxygenation (ECMO). […] Once identified, emergency/expanded use permission for SCD treatment was obtained and patient consented. […] Six COVID-19 patients (4 on ECMO) with severe ARDS were also screened with IL-6 levels less than 100 pg/mL and were not treated with SCD. […] The two patients were successfully weaned off ECMO after 17 and 16 days of SCD therapy respectively. […] The results observed with SCD therapy on these two critically ill COVID-19 patients with severe ARDS and elevated IL-6 is encouraging. […] A multicenter clinical trial is underway with a FDA-approved Investigational Device Exemption to evaluate the potential of SCD therapy to effectively treat COVID-19 ICU patients.
32774640 Nearly 2/3rd of the global burden of sickle cell disease (SCD) is found to be in sub-Saharan Africa. […] The chances of SCD patient contracting COVID-19 infections are higher as these patients are immunocompromised and may be at a higher risk of mortality.
32873056 The management of sickle cell disease (SCD) and its complications in the COVID-19 era is very challenging. […] The recurrent sickling process in SCD causes tissue hypoxemia and micro-infarcts, resulting in end organ damage. […] Since the outbreak of SARS-CoV-2 pandemic, little data has been published about SCD concerning clinical presentation with COVID-19 and management. […] Hydroxyurea has been the cornerstone of management in children and adults with SCD, with evidence of its effect on controlling end organ damage. […] There are several anti-sickling drugs that have been approved recently that might have an additive value toward the management of SCD and its complications. […] Prophylactic anticoagulation should be considered in every management protocol because SCD and COVID-19 are thrombogenic conditions. […] Management proposals of different presentations of patients with SCD and COVID-19 are outlined.
32893954 This novel coronavirus has caused significant respiratory manifestations raising the concern for development of acute chest syndrome (ACS) in patients with sickle cell disease (SCD). […] We report a series of pediatric SCD SARS-COV-2-positive patients admitted with ACS. […] SARS-COV-2-positive SCD patients, who did not develop ACS, were the comparison group.
32980556 Coronavirus disease 2019 (COVID-19) is caused by a newly identified strain of the coronavirus family that has been shown to affect the hemoglobin beta chain, the same chain that has sickle cell disease (SCD) mutation. […] This study was undertaken to see if COVID-19 infection increased disease severity in patients with SCD. […] A total of 38,092 Bahraini people were tested for COVID-19 during this period; 378 (1%) were SCD patients. […] Six patients with SCD had COVID-19 (1.6%): three remained asymptomatic, two had mild symptoms and one required oxygen therapy. […] The SCD patients had a similar average length of stay when compared with non-SCD COVID-19 patients (10.7 days). […] The infection rate, clinical course and viral clearance seen for the SCD patients with COVID-19 were no different to those without SCD.
32999271 We observed individuals affected by spinal cord dysfunction (SCD) after coronavirus disease 2019 (COVID-19). […] The aim of our report is to provide our initial experience with individuals experiencing SCD after COVID-19 in a referral center in Northern Italy, from February 21 to July 15, 2020. […] We report on three men with SCD after COVID-19. […] Prior to SCD, all three individuals suffered from respiratory failure due to COVID-19, required mechanical ventilation, had cardiovascular risk factors, experienced lymphopenia, and received tocilizumab (TCZ). […] To our knowledge, this is the first report of SCD after COVID-19.
33043453 Torsades de pointes (TdP) and sudden cardiac death (SCD) was reported. […] Drug therapy is pro-arrhythmogenic and may result in TdP and SCD in these patients.
33114600 Sickle cell disease (SCD) is a genetic disease that has multiple aspects including public health and clinical aspects.
33136592 We report the emergency use of immunomodulatory therapy utilizing an extracorporeal selective cytopheretic device (SCD) in two patients with elevated serum interleukin (IL)-6 levels and refractory COVID-19 ARDS requiring extracorporeal membrane oxygenation (ECMO). […] Once identified, emergency/expanded use permission for SCD treatment was obtained and patient consented. […] Six COVID-19 patients (four on ECMO) with severe ARDS were also screened with IL-6 levels less than 100 pg/ml and were not treated with SCD. […] The two patients were successfully weaned off ECMO after 17 and 16 days of SCD therapy, respectively. […] The results observed with SCD therapy on these two critically ill COVID-19 patients with severe ARDS and elevated IL-6 is encouraging. […] A multicenter clinical trial is underway with an FDA-approved investigational device exemption to evaluate the potential of SCD therapy to effectively treat COVID-19 intensive care unit patients.
33169059 Myocarditis is an inflammation of the myocardium that can often be associated with cardiac dysfunction and arrhythmias, and is even one of the leading causes for sudden cardiac death (SCD) in athletes.
33173523 Seniors with SCD and MCI underwent lifestyle changes that are potentially harmful to their future cognitive decline, even if, with the exception of leisure activities, they do not appear to be cross-sectionally associated with psychiatric symptoms.
33211045 This test allowed us to perform serial monitoring of two critically ill patients with respiratory failure and to support immunomodulatory therapy using the selective cytopheretic device (SCD).
33230510 Sickle cell disease (SCD) patients are commonly affected by pulmonary complications such as acute chest syndrome (ACS), pulmonary embolism (PE) and pneumonia that contribute to significant mortality risks. […] In emerging small case studies of SCD patients with COVID-19 and further complicated by pneumonia, ACS, and/or PE, the clinical benefits of early exchange transfusion and Tocilizumab are evident.
33235147 Specialty care for children with sickle cell disease (SCD) may be disrupted during the coronavirus (COVID-19) pandemic. […] Our DISPLACE consortium includes 28 pediatric SCD centers. […] The COVID-19 pandemic has affected routine care and necessitated changes in practice in SCD.
33254499 However, there have been case reports of sudden cardiac death (SCD) with the wearing of facemasks during exercise. […] In this paper, we hypothesize that exercise with facemasks may increase the risk of ventricular tachycardia/ventricular fibrillation (VT/VF) leading to SCD via the development of acute and/or intermittent hypoxia and hypercapnia.
33289008 There were 623 pediatric and adult patients with sickle cell disease (SCD) or beta thalassemia (BT) and COVID-19. […] So, our analysis focused on children and adolescents with SCD: there were 121 pediatric patients, one adolescent died, prophylactic anticoagulation was prescribed to six patients, 11.76% needed intensive care unit, blood transfusion was prescribed in 29.70%. […] Vaso-occlusive crisis (VOC) and acute chest syndrome (ACS) were the main clinical manifestations in SCD. […] Pediatric patients with SCD and COVID-19 have a low mortality rate when compared to adults, although is higher than the global pediatric population with COVID-19 (0-0.67%). […] In SCD the clinical manifestations, both in children and adults, are VOC and ACS, and there was increase in blood requirement. […] Pediatric SCD patients with COVID-19 need more intensive care unit than the global pediatric population (3.30%). […] Despite pediatric population with SCD needs more intensive care, the outcome after infection by COVID-19 is favorable.
33446428 We aimed to evaluate COVID-19 and sickle cell disease (SCD)-related experiences, and the clinical course during the outbreak, to measure anxiety levels of adolescent and young adult patients with homozygous SCD, to analyze the correlations between their COVID-19 experiences and anxiety levels and painful episodes. […] These descriptive and correlation findings are the first reported on COVID-19-related anxiety in SCD patients. […] To develop screening and support strategies for mental health needs in pandemic times, further SCD studies should be conducted.
33512869 During this pandemic, patients with sickle cell disease (SCD) have been placed in the “high-risk” category of the population. […] Although SCD patients are considered as a high-risk group, all of the observed patients, and whose cases are reported here, have recovered. […] A large scale of SCD cases should be studied to reach more conclusive results.
33514354 The global spread of CoV2-SARS infection with a respiratory tropism, endothelial damages and procoagulant status endangers the SCD population. […] However, with only a few case reports, consequences of the Covid-19 pandemic on SCD population remain poorly known. […] This case recalls the importance of an increased prevention policy against COVID-19among the SCD population. […] (3) Unexpectedly, our patient did not develop pulmonary arterial hypertension (PAH) and acute cor pulmonale (ACP), whereas this is a common feature of ARDS during SCD. […] These last two observations suggest a different pathophysiology of pulmonary disorders in SCD patients in the case of SARS COv2.
33520543 Workup for anemia led to the diagnosis of sickle cell disease (SCD). […] Most commonly, patients are diagnosed with thrombophilia or have an underlying hypercoagulable state such as with SCD. […] In this report, we present a case of a late adolescent female with SCD, who was diagnosed with COVID-19, and whose condition was complicated with PE.
33570644 We aimed to identify predictors of outcomes and survival in patients living in 4 major metropolitan areas who had sickle cell disease (SCD) and COVID-19 to inform best approaches to prevention and care. […] Data were collected at baseline and during the clinical course in SCD patients diagnosed with COVID-19 in four COVID-19 epicenters. […] Of sixty-six SCD patients with COVID-19, fifty patients (75%) required hospitalization, and seven died (10.6%). […] All deaths occurred in individuals not taking hydroxyurea or any other SCD-modifying therapy. […] Patients with SCD and COVID-19 exhibited a broad range of disease severity. […] We cannot definitively state that the overall mortality is higher in patients with SCD, although our case fatality rate was ∼10% compared with ∼3% in the general population, despite a median age of 34 years. […] Individuals with SCD aged >50 years, with preexisting cardiopulmonary, renal disease, and/or stroke not receiving hydroxyurea, who present with high serum creatinine, lactate dehydrogenase, and D-dimer levels, are at higher risk of death, irrespective of genotype or sex.
33572620 In March 2020, dental care providers, including special care dentistry (SCD) services, had to face an extraordinary change of their standard operating procedures (SOP), with deferred domiciliary dental care, withholding conscious dental sedation services and disrupted routine care […].