NPC intracellular cholesterol transporter 1

Gene Context Sentence

Table 2. Analysis of context sentence of NPC1 gene in 1 abstracts.

PMID Gene Context Sentence
32457038 The NP-C disease-causing gene (NPC1) has been strongly associated with viral infection, as a filovirus receptor (e.g., Ebola) and through LE/L lipid trafficking. […] This suggests NPC1 inhibitors or NP-C disease mimetics could serve as anti-SARS-CoV-2 agents. […] Inhibition of NPC1 may impair viral SARS-CoV-2 infectivity via several lipid-dependent mechanisms, which disturb the microenvironment optimum for viral infectivity. […] We suggest that known mechanistic information on NPC1 could be utilized to identify existing and future drugs to treat COVID-19.