PFAS
phosphoribosylformylglycinamidine synthase
Gene Context Sentence
Table 2. Analysis of context sentence of PFAS gene in 1 abstracts.
| PMID | Gene Context Sentence |
|---|---|
| 33382826 | The course of coronavirus disease 2019 (COVID-19) seems to be aggravated by air pollution, and some industrial chemicals, such as the perfluorinated alkylate substances (PFASs), are immunotoxic and may contribute to an association with disease severity. […] The PFAS concentrations measured at the background exposures included five PFASs known to be immunotoxic. […] We used ordered logistic regression analyses to determine associations between PFAS concentrations and disease outcome. […] Plasma-PFAS concentrations were higher in males, in subjects with Western European background, and tended to increase with age, but were not associated with the presence of chronic disease. […] Among the five PFASs considered, perfluorobutanoic acid (PFBA) showed an unadjusted odds ratio (OR) of 2.19 (95% confidence interval, CI, 1.39-3.46) for increasing severities of the disease. […] Measures of individual exposures to immunotoxic PFASs included short-chain PFBA known to accumulate in the lungs. […] Given the low background exposure levels in this study, the role of exposure to PFASs in COVID-19 needs to be ascertained in populations with elevated exposures. |