platelet factor 4
Gene Context Sentence
Table 2. Analysis of context sentence of PF4 gene in 4 abstracts.
|PMID||Gene Context Sentence|
|32720827||He had a high pretest probability for HIT with a 4T score of 6 and a positive anti-PF4/heparin antibody.|
|32838110||We agree that false-positive enzyme immunoassay (EIA) detection of anti-platelet factor 4 (PF4)/heparin antibodies could explain the results we observed in patients #2 and #3 (2), and this has been the conventional interpretation when functional testing (such as the serotonin-release assay [SRA]) returns negative.|
|33050376||Platelet factor 4 (PF4, CXCL4) is a small chemokine protein released by activated platelets. […] Although a major physiological function of PF4 is to promote blood coagulation, this cytokine is involved in innate and adaptive immunity in events when platelets are activated in response to infections. […] Anti-PF4 antibodies are frequently detected in severe patients and heparin-induced thrombocytopenia (HIT) can also be observed. […] PF4 and its role in HIT as well as in pathologies seen in COVID-19 patients define a potential therapeutic option of using blocking antibodies in the treatment of COVID-19.|
|33550713||Heparin-induced thrombocytopenia (HIT) is a severe adverse reaction to heparin caused by heparin-dependent, platelet activating anti-platelet factor 4 (PF4)/heparin antibodies. […] We observed an unexpectedly high percentage of COVID-19 patients, clinically suspected to have HIT, with high titer anti-PF4/heparin antibodies, but a negative functional test. […] Also the purified IgG fractions of COVID-19 sera testing strongly positive in the PF4/heparin antigen test but negative in the functional test did not show increased reactivity in the functional test in comparison to the original serum. […] COVID-19 patients often present with strong reactivity in PF4/heparin antigen tests without the presence of platelet-activating antibodies.|