OXT

oxytocin/neurophysin I prepropeptide

Gene Context Sentence

Table 2. Analysis of context sentence of OXT gene in 2 abstracts.

PMID	Gene Context Sentence
32809918	Here, we are proposing intravenous oxytocin (OXT) as a candidate for adjunctive therapy for COVID-19. […] OXT has anti-inflammatory and proimmune adaptive functions. […] Using the Library of Integrated Network-Based Cellular Signatures (LINCS), we used the transcriptomic signature for carbetocin, an OXT agonist, and compared it to gene knockdown signatures of inflammatory (such as interleukin IL-1β and IL-6) and proimmune markers (including T cell and macrophage cell markers like CD40 and ARG1).
33513400	Oxytocin (OXT), an immune-regulating neuropeptide, has recently emerged as a strong candidate for treatment and prevention of COVID-19 pandemic. […] OXT carries special functions in immunologic defense, homeostasis and surveillance. […] Additionally, OXT can promote γ-interferon expression to inhibit cathepsin L and increases superoxide dismutase expression to reduce heparin and heparan sulphate fragmentation. […] Through these mechanisms, OXT can block viral invasion, suppress cytokine storm, reverse lymphocytopenia, and prevent progression to ARDS and multiple organ failures. […] Importantly, besides prevention of metabolic disorders associated with atherosclerosis and diabetes mellitus, OXT can protect the heart and vasculature through suppressing hypertension and brain-heart syndrome, and promoting regeneration of injured cardiomyocytes. […] Unlike other therapeutic agents, exogenous OXT can be used safely without the side-effects seen in remdesivir and corticosteroid. […] Importantly, OXT can be mobilized endogenously to prevent pathogenesis of COVID-19. […] This article summarizes our current understandings of cardiovascular pathogenesis caused by COVID-19, explores the protective potentials of OXT against COVID-19-associated cardiovascular diseases, and discusses challenges in applying OXT in treatment and prevention of COVID-19.