NUP98
nucleoporin 98 and 96 precursor
Gene Context Sentence
Table 2. Analysis of context sentence of NUP98 gene in 3 abstracts.
| PMID | Gene Context Sentence |
|---|---|
| 33097660 | We found that SARS-CoV-2 Orf6 localizes at the nuclear pore complex (NPC) and directly interacts with Nup98-Rae1 via its C-terminal domain to impair docking of cargo-receptor (karyopherin/importin) complex and disrupt nuclear import. […] In addition, we show that a methionine-to-arginine substitution at residue 58 impairs Orf6 binding to the Nup98-Rae1 complex and abolishes its IFN antagonistic function. […] All together our data unravel a mechanism of viral antagonism in which a virus hijacks the Nup98-Rae1 complex to overcome the antiviral action of IFN. |
| 33126048 | Other proteins that interact with SARS-CoV-2 like LOX, Fibulins-2 and 5, NUP98, GDF15, RBX1, CUL3, HMOX1, PLAT, MFGE8, and MRPs are vital in placental functions like trophoblast invasion and migration, syncytium formation, differentiation, and implantation. |
| 33360543 | We found that ORF6 protein disrupted nuclear rim staining of nucleoporins RAE1 and NUP98. |