matrix Gla protein

Gene Context Sentence

Table 2. Analysis of context sentence of MGP gene in 4 abstracts.

PMID Gene Context Sentence
32852539 Vitamin K also activates matrix Gla protein (MGP), which protects against pulmonary and vascular elastic fiber damage. […] Inactive vitamin K-dependent MGP (dp-ucMGP) and prothrombin (PIVKA-II) were measured, inversely related to extrahepatic and hepatic vitamin K status, respectively. […] Dp-ucMGP was elevated in COVID-19 patients compared to controls (p<0.001), with even higher dp-ucMGP in patients with poor outcomes (p<0.001). […] Dp-ucMGP was correlated with desmosine (p<0.001), and coronary artery (p=0.002) and thoracic aortic (p<0.001) calcification scores. […] Dp-ucMGP was severely increased in COVID-19 patients, indicating extrahepatic vitamin K insufficiency, which was related to poor outcome while hepatic procoagulant factor II remained unaffected. […] These data suggest a mechanism of pneumonia-induced extrahepatic vitamin K depletion leading to accelerated elastic fiber damage and thrombosis in severe COVID-19 due to impaired activation of MGP and endothelial protein S, respectively.
33023681 Matrix Gla protein (MGP) is a vitamin K-dependent inhibitor of soft tissue calcification and elastic fibre degradation. […] Severe extrahepatic vitamin K insufficiency was recently demonstrated in Covid-19 patients, with high inactive MGP levels correlating with elastic fibre degradation rates. […] This suggests that insufficient vitamin K-dependent MGP activation leaves elastic fibres unprotected against SARS-CoV-2-induced proteolysis. […] In contrast to MGP, Covid-19 patients have normal levels of activated factor II, in line with previous observations that vitamin K is preferentially transported to the liver for activation of procoagulant factors. […] Taking these data together, we propose a mechanism of pneumonia-induced vitamin K depletion, leading to a decrease in activated MGP and protein S, aggravating pulmonary damage and coagulopathy, respectively.
33100900 concentrations was recorded in Kolkata (64%) (LGP) followed by Muzaffarpur (53%) (MGP), Asansol (51%) (LGP), Patna (43%) (MGP) and Varanasi (33%) (MGP).
33259652 To assess clinical presentations, pregnancy complications, and maternal and neonatal outcomes among women with multiple gestation pregnancy (MGP) and confirmed SARS-CoV-2 (COVID-19) infection and to compare the data with a pre-pandemic period. […] Data were also compared with a cohort of women with MGP attending the hospital pre-pandemic (n = 63). […] Data from 879 women (singleton pregnancy, n = 859; MGP, n = 20) with COVID-19 were assessed. […] As compared with singleton pregnancies, a higher proportion of women with MGP and Covid-19 delivered preterm (P = 0.001). […] Spontaneous abortions were also higher in the MGP group than in the singleton group (P = 0.055). […] The incidence of pre-eclampsia/eclampsia was higher in the COVID-19 MGP group than in both the COVID-19 singleton (41.6% vs. […] 7.9%) and pre-pandemic MGP (50.0% vs. […] There was a higher risk of pre-eclampsia among women with MGP and COVID-19. […] Women with MGP and COVID-19 infection should receive special attention with a multidisciplinary approach to both maternal and neonatal care during the pandemic.