interferon induced protein with tetratricopeptide repeats 1

Gene Context Sentence

Table 2. Analysis of context sentence of IFIT1 gene in 5 abstracts.

PMID Gene Context Sentence
32599245 These ISGs (IFIT1, IFITM1, IRF7, ISG15, MX1, and OAS2) can be considered as potential candidates for drug targets in the treatments of COVID-19.
32646047 Several interferon (IFN) responsive gene targets (IRF9, IFIT1, IFIT2, IFIT3, IFITM1, MX1, OAS2, OAS3, IFI44 and IFI44L) were highly upregulated in SARS-CoV-2 infected NBHE cell, implying activation of antiviral IFN innate response.
32898168 SARS-CoV-2 induced a strong antiviral response with up-regulation of antiviral factors such as OAS1-3 and IFIT1-3 and T helper type 1 (Th1) chemokines CXCL9/10/11, as well as a reduction in transcription of ribosomal proteins.
33045833 To ensure reliability of the proteomics data, two randomly selected DEPs, the downregulated anaphase-promoting complex subunit 7 (ANAPC7) and upregulated interferon-induced protein with tetratricopeptide repeats 1 (IFIT1), were verified by real-time PCR and Western blot, and the results of which indicate that the proteomics data were reliable and valid.
33326977 Role of IFIT1/2/3 in the expression of C-X-C motif chemokine ligand 10 (CXCL10) was also examined. […] Real-time qPCR, Western blotting, and ELISA were used to examine the expression of IFIT1/2/3, IFN-β, and CXCL10. […] RNA interference against IFN-β or IFIT1/2/3 was also performed. […] Expression of IFIT1/2/3 and CXCL10 was induced by poly IC in GECs. […] Knockdown of IFIT1/2/3 decreased the CXCL10 expression. […] Knockdown of IFIT3 decreased the expression of IFIT1 and IFIT2 proteins. […] IFIT1/2/3 and CXCL10 were induced by poly IC via IFN-β in GECs. […] IFIT1/2/3 may increase the expression of CXCL10 which induces lymphocyte chemotaxis and may inhibit the replication of infected viruses.