interferon induced protein with tetratricopeptide repeats 2

Gene Context Sentence

Table 2. Analysis of context sentence of IFIT2 gene in 3 abstracts.

PMID Gene Context Sentence
32646047 Several interferon (IFN) responsive gene targets (IRF9, IFIT1, IFIT2, IFIT3, IFITM1, MX1, OAS2, OAS3, IFI44 and IFI44L) were highly upregulated in SARS-CoV-2 infected NBHE cell, implying activation of antiviral IFN innate response.
33253295 The interferon-induced tetratricopeptide repeat protein (Ifit2) protects mice from lethal neurotropic viruses. […] Neurotropic coronavirus MHV-RSA59 infection of Ifit2-/- mice caused pronounced morbidity and mortality accompanied by rampant virus replication and spread throughout the brain. […] In spite of the higher virus load, induction of many cytokines and chemokines in the brains of infected Ifit2-/- mice were similar to that in wild-type mice. […] In contrast, infected Ifit2-/- mice revealed significantly impaired microglial activation as well as reduced recruitment of NK1.1 T cells and CD4 T cells to the brain, possibly contributing to the lack of viral clearance.
33326977 Knockdown of IFIT3 decreased the expression of IFIT1 and IFIT2 proteins.