HLA-E
major histocompatibility complex, class I, E
Gene Context Sentence
Table 2. Analysis of context sentence of HLA-E gene in 3 abstracts.
| PMID | Gene Context Sentence |
|---|---|
| 32859121 | Further experiments revealed a concomitant induction of HLA-E expression on the surface of lung epithelial cells and the recognition of an SP1-derived HLA-E-binding peptide. […] We ruled out the GATA3 transcription factor as being responsible for HLA-E increased levels and HLA-E/NKG2A interaction as implicated in NK cell exhaustion. […] We show for the first time that NK cells are affected by SP1 expression in lung epithelial cells via HLA-E/NKG2A interaction. |
| 33046268 | I suggest HLA-G and HLA-E, non classical HLA class I molecules, in the core of COVID-19 complications. […] I recommend also developing new SARS-CoV2 therapies based on the use of HLA-G and HLA-E or their specific receptors antibodies in combination with FDA approved therapeutics to combat efficiently COVID-19. |
| 33500568 | In addition, HLA-E0101/0103 genetic variants occur, caused by a single-nucleotide polymorphism. […] We investigated the distribution of KLRC2 deletion and HLA-E0101/0103 allelic variants in a study cohort of 361 patients with either mild (N = 92) or severe (N = 269) COVID-19. , and at a lower degree the HLA-E*0101, allele were significantly overrepresented in hospitalized patients (p = 0.0006 and p = 0.01), particularly in patients requiring intensive care (p < 0.0001 and p = 0.01), compared with patients with mild symptoms. […] Our data show that these genetic variants in the NKG2C/HLA-E axis have a significant impact on the development of severe SARS-CoV-2 infections, and may help to identify patients at high-risk for severe COVID-19. |