major histocompatibility complex, class I, C

Gene Context Sentence

Table 2. Analysis of context sentence of HLA-C gene in 7 abstracts.

PMID Gene Context Sentence
32424945 Frequencies of the HLA-C07:29, C08:01G, B15:27, B40:06, DRB104:06, and DPB136:01 alleles were higher, while the frequencies of the DRB112:02 and DPB104:01 alleles were lower in COVID-19 patients than in the control population, with uncorrected statistical significance. […] Only HLA-C07:29 and B15:27 were significant when the corrected P value was considered.
32623831 Likewise, HLA-A02, HLA-B44 and HLA-C*05 may exert a protective effect, but these associations did not remain significant after correction for multiple tests.
32717807 Our epidemiologic analysis, despite the limits of the ecological approach, is strongly suggestive of a permissive role of HLA-C01 and B44 towards SARS-CoV-2 infection, which warrants further investigation in case-control studies.
32759312 Our analyses consisted in searching for the most frequent Human Leukocyte Antigen (HLA)-A, HLA-B and HLA-C alleles in the Brazilian population, excluding the genetic isolates; then, we performed: molecular modelling for unsolved structures, MHC-I binding affinity and antigenicity prediction, peptide docking and molecular dynamics of the best fitted MHC-I/protein S complexes. […] We identified 24 immunogenic epitopes in the SARS-CoV-2 protein S that could interact with 17 different MHC-I alleles (namely, HLA-A01:01; HLA-A02:01; HLA-A11:01; HLA-A24:02; HLA-A68:01; HLA-A23:01; HLA-A26:01; HLA-A30:02; HLA-A31:01; HLA-B07:02; HLA-B51:01; HLA-B35:01; HLA-B44:02; HLA-B35:03; HLA-C05:01; HLA-C07:01 and HLA-C*15:02) in the Brazilian population.
32988645 We found a trend to a higher rate of the alleles HLA-A32 (p=0.004) in healthy controls than in COVID-19 patients, and of the alleles HLA-B39 (p=0.02) and HLA-C16 (p=0.02) in COVID-19 patients than in healthy controls; however, all these p-values were not significant after correction for multiple comparisons. […] Logistic regression analysis showed that the presence of certain alleles was associated with higher mortality, such as the allele HLA-A11 after controlling for SOFA (OR=7.693; 95% CI=1.063-55.650; p=0.04) or APACHE-II (OR=11.858; 95% CI=1.524-92.273; p=0.02), the allele HLA-C01 after controlling for SOFA (OR=11.182; 95% CI=1.053-118.700; p=0.04) or APACHE-II (OR=17.604; 95% CI=1.629-190.211; p=0.02), and the allele HLA-DQB104 after controlling for SOFA (OR=9.963; 95% CI=1.235-80.358; p=0.03).
33343579 The extended haplotype HLA-A02:05, B58:01, C07:01, DRB103:01 [OR 0.1 (95% CI 0-0.6), Pc = 0.015] was absent in all 182 patients, while the HLA-C04:01 allele and the three-loci haplotype HLA-A30:02, B14:02, C08:02 [OR 3.8 (95% CI 1.8-8.1), Pc = 0.025] were more frequently represented in patients than controls.
33539638 HLA-C15:227 differs from HLA-C15:02:01:01 by a single nonsynonymous change (368A → G Tyrosine 99 to Cysteine).