HLA-B

major histocompatibility complex, class I, B

Gene Context Sentence


Table 2. Analysis of context sentence of HLA-B gene in 14 abstracts.

PMID Gene Context Sentence
32303592 However, we found that HLA-B46:01 had the fewest predicted binding peptides for SARS-CoV-2, suggesting individuals with this allele may be particularly vulnerable to COVID-19, as they were previously shown to be for SARS (Lin M, Tseng H-K, Trejaut JA, Lee H-L, Loo J-H, Chu C-C, Chen P-J, Su Y-W, Lim KH, Tsai Z-U, Lin R-Y, Lin R-S, Huang C-H. […] Conversely, we found that HLA-B15:03 showed the greatest capacity to present highly conserved SARS-CoV-2 peptides that are shared among common human coronaviruses, suggesting it could enable cross-protective T-cell based immunity.
32623831 Likewise, HLA-A02, HLA-B44 and HLA-C*05 may exert a protective effect, but these associations did not remain significant after correction for multiple tests.
32717807 Among all the alleles, HLA-A25, B08, B44, B15:01, B51, C01, and C03 showed a positive log-linear correlation with COVID-19 incidence rate fixed on 9 April 2020 in proximity of the national outbreak peak (Pearson’s coefficients between 0.50 and 0.70, p-value < 0.0001), whereas HLA-B14, B18, and B49 showed an inverse log-linear correlation (Pearson’s coefficients between -0.47 and -0.59, p-value < 0.0001). […] When alleles were examined simultaneously using a multiple regression model to control for confounding factors, HLA-B44 and C01 were still positively and independently associated with COVID-19: a growth rate of 16% (95%CI: 0.1-35%) per 1% point increase in B44 prevalence; and of 19% (95%CI: 1-41%) per 1% point increase in C01 prevalence.
32759312 Our analyses consisted in searching for the most frequent Human Leukocyte Antigen (HLA)-A, HLA-B and HLA-C alleles in the Brazilian population, excluding the genetic isolates; then, we performed: molecular modelling for unsolved structures, MHC-I binding affinity and antigenicity prediction, peptide docking and molecular dynamics of the best fitted MHC-I/protein S complexes. […] We identified 24 immunogenic epitopes in the SARS-CoV-2 protein S that could interact with 17 different MHC-I alleles (namely, HLA-A01:01; HLA-A02:01; HLA-A11:01; HLA-A24:02; HLA-A68:01; HLA-A23:01; HLA-A26:01; HLA-A30:02; HLA-A31:01; HLA-B07:02; HLA-B51:01; HLA-B35:01; HLA-B44:02; HLA-B35:03; HLA-C05:01; HLA-C07:01 and HLA-C*15:02) in the Brazilian population.
32828069 They interact with the HLA-B*15:01 allele, which was further validated by molecular docking simulation.
32988645 We found a trend to a higher rate of the alleles HLA-A32 (p=0.004) in healthy controls than in COVID-19 patients, and of the alleles HLA-B39 (p=0.02) and HLA-C*16 (p=0.02) in COVID-19 patients than in healthy controls; however, all these p-values were not significant after correction for multiple comparisons.
33024578 Furthermore, four of the human 8-mer/9-mer peptides mimicked by SARS-CoV-2 map onto HLA-B40:01, HLA-B40:02, and HLA-B*35:01 binding peptides from human PAM, ANXA7, PGD, and ALOX5AP proteins.
33085221 We characterized medication orders, focusing on medications with actionable PGx guidance related to 14 commonly assayed genes (CYP2C19, CYP2C9, CYP2D6, CYP3A5, DPYD, G6PD, HLA-A, HLA-B, IFNL3, NUDT15, SLCO1B1, TPMT, UGT1A1, and VKORC1).
33179437 HLA system is critical in mediating anti-viral immunity and recent studies have suggested preferential involvement of HLA-B in COVID-19 susceptibility. […] Here, by investigating the HLA-B genotypes in 190 unrelated Chinese patients with confirmed COVID-19, we identified a significant positive association between the B22 serotype and SARS-CoV-2 infection (p = 0.002, Bonferroni-corrected p = 0.032).
33301503 We found diverse capacities of S protein specific epitope presentation by different HLA alleles with very limited number of predicted epitopes for HLA-B2705, HLA-B4402 and HLA-B4403 and as high as 132 epitopes for HLA-A6601.
33361777 To help achieve these aims, we profiled the entire SARS-CoV-2 proteome across the most frequent 100 HLA-A, HLA-B and HLA-DR alleles in the human population, using host-infected cell surface antigen presentation and immunogenicity predictors from the NEC Immune Profiler suite of tools, and generated comprehensive epitope maps.
33403186 Weak HLA-B alleles of 30 repertoires or less had no correlation with the severity rate (R=-0.1530).
33542445 The major drug variant pairs that associated with variations in adverse effects include CQ/HCQ (G6PD; hemolysis and ABCA4; retinopathy), ATV (MDR1 and UGT1A128; hyperbilirubinemia; and APOA5; dyslipidemia), NVP (HLA-DRB101, HLA-B*3505 and CYP2B6; skin rash and MDR1; hepatotoxicity), and EFV (CYP2B6; depression and suicidal tendencies).
33546902 The present study retrieved data sets of HLA-B alleles, KIR genes and functional single nucleotide polymorphisms (SNPs) in cytokines related to COVID-19 cytokine storm from two publicly available databases: Allele Frequency Net Database and Ensembl, and correlated these frequency data with Case Fatality Rate (CFR) and Daily Death Rates (DDR) across countries. […] Correlations of eight HLA-B alleles and polymorphisms in three cytokine genes (IL6, IL10, and IL12B) were observed and were mainly associated with DDR. […] Additionally, HLA-B correlations suggest that differences in allele affinities to SARS-CoV-2 peptides are also associated with DDR.