C-X-C motif chemokine receptor 3

Gene Context Sentence

Table 2. Analysis of context sentence of CXCR3 gene in 7 abstracts.

PMID Gene Context Sentence
32253888 The X chromosome influences the immune system by acting on many other proteins, including TLR8, CD40L and CXCR3 which can be over-expressed in women, and influence the response to viral infections and vaccinations.
32257537 After treatment, the peripheral lymphocytes were increased, the C-reactive protein decreased, and the overactivated cytokine-secreting immune cells CXCR3+CD4+ T cells, CXCR3+CD8+ T cells, and CXCR3+ NK cells disappeared in 3-6 days.
32543740 On admission, compared to patients with poor prognoses, those with good prognoses had significantly higher counts of monocytes (p < 0.05), macrophages (p < 0.05), higher frequency of CD3+ CD4+ CD45RO+ CXCR3+ subsets (p < 0.05), higher frequency of CD14+ CD11C+ HLA-DR+ subset of dendritic cells (DCs) (p < 0.05), and a lower count of neutrophils (p < 0.05).
32898168 Older individuals had reduced expression of the Th1 chemokines CXCL9/10/11 and their cognate receptor CXCR3, as well as CD8A and granzyme B, suggesting deficiencies in trafficking and/or function of cytotoxic T cells and natural killer (NK) cells.
33138839 Targeting the CXCL10-CXCR3 axis could also be considered as a new therapeutic approach.
33324414 On the one hand, there was a consistent lymphopenia with an overrepresentation of non-functional T cells, with an increased percentage of naive Th cells (CD45RA+, CXCR3-, CCR4-, CCR6-, CCR10-) and persistently low frequency of markers associated with Th1, Th17, and Th1/Th17 memory-effector T cells compared to healthy donors.
33343897 ILC2 and ILCp showed an activated phenotype with increased CD69 expression, whereas expression levels of the chemokine receptors CXCR3 and CCR4 were significantly altered in ILC2 and ILCp, and ILC1, respectively.