ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

Gene Context Sentence

Table 2. Analysis of context sentence of ABO gene in 66 abstracts.

PMID Gene Context Sentence
32293713 In order to evaluate the efficacy of convalescent plasma therapy in COVID-19 patients, we did this timely descriptive study. 6 laboratory confirmed COVID-19 patients were enrolled and received the transfusion of ABO-compatible convalescent plasma. […] The efficacy of this intervention was determined by the alleviation of symptoms, changes in radiologic abnormalities and laboratory tests.
32337859 He received a second KT from an ABO-incompatible donor 8 years ago.
32389803 We recorded higher 1-year rates of graft failure (hazard ratio [HR], 2.26; 95% confidence interval, 1.17 to 4.35; P = .01) and of 1-year overall mortality (HR, 3.13; 95% CI, 1.60 to 6.11; P = .0008) after transplantation of cryopreserved compared with noncryopreserved grafts, with adjustment for sex, performance score, comorbidity, cytomegalovirus serostatus, and ABO blood group match.
32400013 There has been growing concern about donor-derived transmissions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] Herein, we present the case of a patient who underwent ABO-incompatible living donor liver transplantation without knowing that the liver donor was infected with COVID-19 during the donation procedure.
32420611 We read with interest the recent report from Li and colleagues describing an association between ABO blood groups and risk of SARS-CoV-2 pneumonia [1]. […] Subsequently, in a larger validation cohort that included 2153 patients with COVID-19, this ABO effect was reproduced with blood group O again being associated with a significant protective effect (p < 0.001).
32423094 Data from the World Health Organization (WHO) and Chinese scientists show that of all cases about 1.7% of women who contract the virus will die compared with 2.8% of men, and data from Hong Kong hospitals state that 32% of male and 15% of female COVID-19 patients required intensive care or died. […] Other genes, out from the RAS-pathway, might directly or indirectly impact on the ACE1/ACE2 balance by influencing its main actors (e.g., ABO locus, SRY, SOX3, ADAM17).
32453863 Juyi Li et al. [1] have recently published “an association between ABO blood groups and risk of SARS-CoV-2 pneumonia”, an observation already reported a few weeks ago as a MedRxiv preprint by Jiao Zhao et al. [2] and which had a certain impact in the press.
32516462 I read with interest the recent article by Li et al (1) detailing the risk for COVID-19 pneumonia and ABO blood group.
32525844 Thus, we analyzed key safety metrics after transfusion of ABO compatible human COVID-19 convalescent plasma in 5,000 hospitalized adults with severe or life threatening COVID-19, with 66% in the intensive care unit, as part of the US FDA Expanded Access Program for COVID-19 convalescent plasma.
32558485 The association signal at locus 9q34.2 coincided with the ABO blood group locus; in this cohort, a blood-group-specific analysis showed a higher risk in blood group A than in other blood groups (odds ratio, 1.45; 95% CI, 1.20 to 1.75; P = 1.48×10-4) and a protective effect in blood group O as compared with other blood groups (odds ratio, 0.65; 95% CI, 0.53 to 0.79; P = 1.06×10-5). […] We identified a 3p21.31 gene cluster as a genetic susceptibility locus in patients with Covid-19 with respiratory failure and confirmed a potential involvement of the ABO blood-group system.
32562665 To explore ABO blood group distribution and clinical characteristics in patients with COVID-19. […] The differences in the ABO blood group distribution between COVID-19 patients and the control group (1991 cases) were analyzed. […] The ABO blood group distribution was related to COVID-19 status. […] Patients with blood group A had an increased risk for infection with SARS-CoV-2, whereas blood group O was associated with a decreased risk, indicating that certain ABO blood groups were correlated with SARS-CoV-2 susceptibility.
32573724 To comprehensively evaluate the effectiveness, safety, and indications of convalescent plasma transfusion (CPT) therapy for severe or critical COVID-19 patients, we analyzed the clinical, laboratory, and radiologic characteristics of 1,568 patients from a single center, in which 138 patients received ABO-compatible CPT.
32593060 In testing, ABO compatibility is assessed after classifying donors into the four blood types, namely, A, B, AB and O, to indicate the suitability and safety of plasma for administration in order to refine the CP tested list repository.
32609874 Blood group antigens may influence disease susceptibility by several mechanisms, including serving as receptors or decoys for infectious organisms and modifying immune response in the form of anti-ABO antibodies.
32627216 Whereas levels of N-specific IgM antibody declined after recovery, S-RBD-specific and N-specific IgG antibodies increased after 4 weeks from the onset of symptoms, with no significant correlation to age, sex, or ABO blood type.
32627442 Although convalescent plasma (CP) therapy can be useful in the treatment of COVID-19, it has not been widely used in Korea because of the concerns about adverse effects and the difficulty in matching patients to donors. […] The use of ABO-incompatible plasma is not contraindicated in treatment, but can be hesitated due to the lack of experience of physicians. […] Here, we describe a 68-year old man with COVID-19 who was treated ABO-incompatible plasma therapy; additionally, we comment on the acute side effects associated with ABO mismatch transfusion.
32656591 This study aimed to determine if there is an association between ABO blood type and severity of COVID-19 defined by intubation or death as well as ascertain if there is variability in testing positive for COVID-19 between blood types.
32739464 The pathogen of COVID-19 is SARS-COV-2, and previous studies have proposed the relationship between ABO blood group and coronavirus. […] Here, we aim to delve into the association between ABO blood group and COVID-19 infection, severity and demise. […] Compared to other ABO blood type, an increased odds of infecting COVID-19 among individuals with A blood group (OR: 1.249, 95%CI: 1.114-1.440, P < 0.001) and a decreased odds of infecting COVID-19 among individuals with blood group O (OR: 0.699, 95%CI: 0.635-0.770, P < 0.001) were found. […] The current meta-analysis suggest that blood type A might be more susceptible to infect COVID-19 while blood type O might be less susceptible to infect COVID-19; there were no correlation between ABO blood group and severity or demise of COVID-19. […] However, more investigation and research are warranted to clarify the relationship between COVID-19 and ABO blood type.
32750119 To explore any relationship between the ABO blood group and the COVID-19 susceptibility, we compared ABO blood group distributions in 2,173 COVID-19 patients with local control populations, and found that blood group A was associated with an increased risk of infection, whereas group O was associated with a decreased risk.
32754209 In the present study, we have investigated the connection between ABO histo-blood group phenotypes and the COVID-19. […] Our results demonstrated ABO histo-blood phenotypes are correlated with patients’ susceptibility to the infection. […] Similar to several previous studies about other viral diseases’ association with ABO histo-blood groups, we have concluded that an individual’s ABO histo-blood group phenotype and his/her susceptibility to COVID-19 are indeed connected. […] So far, only one research has been conducted about this association.
32793517 Background: The ABO blood group system has been associated with multiple infectious diseases, including hepatitis B, dengue haemorrhagic fever and so on. […] Coronavirus disease 2019 (COVID-19) is a new respiratory infectious disease and the relationship between COVID-19 and ABO blood group system needs to be explored urgently. […] Finally, considering lymphopenia as a feature of COVID-19, the relationship between the ABO blood group and the lymphocyte count was determined in case samples. […] Association analysis between the ABO blood group and COVID-19 indicated that there was a statistically significant difference for blood type A (P = 0.04, OR = 1.33, 95% CI = 1.02-1.73) but not for blood types B, AB or O (P = 0.48, OR = 0.90, 95% CI = 0.66-1.23; P = 0.61, OR = 0.88, 95% CI = 0.53-1.46; and P = 0.23, OR = 0.82, 95% CI = 0.58-1.15, respectively).
32814635 Some studies suggests that the ABO blood group could be a biological marker of susceptibility for the development of the disease. […] We collected data from patients admitted with COVID-19 infection who had ABO blood group recorded, and analyzed the incidence by groups, compared with the global population in Navarre, as well as their main complications and evolution.
32837730 The relationship between ABO blood group and the incidence of coronavirus disease 2019 (COVID-19) infection and death has been investigated in several studies. […] The estimated frequency of COVID-19 infection and death in terms of ABO blood group and the overall estimate of the odds ratio between blood group with COVID-19 infection and death was calculated with 95% confidence interval.
32872048 Growing evidence suggests that the ABO blood type contributed to the susceptibility of COVID-19, but the results are controversial. […] The major objective of this systematic review and meta-analysis study is to investigate the impact of ABO blood group on COVID-19 pneumonia. […] This study will provide high-quality evidence to evaluate the contribution of the ABO blood group in COVID-19 pneumonia infection.
32899439 Accordingly, we recently published a genetic hypothesis on the role of RAS-pathway genes (ACE1, rs4646994, rs1799752, rs4340, rs13447447; and ACE2, rs2285666, rs1978124, rs714205) and ABO-locus (rs495828, rs8176746) in COVID-19 prognosis, suspecting inherited genetic predispositions to be predictive of COVID-19 severity. […] In addition, recently, Genome-Wide Association Studies (GWAS) found COVID-19-association signals at locus 3p21.31 (rs11385942) comprising the solute carrier SLC6A20 (Na+ and Cl- coupled transporter family) and at locus 9q34.2 (rs657152) coincident with ABO-blood group (rs8176747, rs41302905, rs8176719), and interestingly, both loci are associated to RAS-pathway.
32946531 At present, existing evidence about the association between SARS-CoV-2 infection and ABO blood group polymorphism is preliminary and controversial.
32965363 The aim of this study is to analyze the prognostic significance of ABO and Rh blood group antigens along with various parameters in patients followed-up with the diagnosis of COVID-19. […] The ages, genders, chronic diseases, ABO and Rh blood group antigens, admission rates to Intensive Care Units (ICU), and mortality rates of the patients were analyzed.
32983543 In Sudan, several haematological studies were conducted to study the ABO blood group distribution among the population, in which the O blood group was dominant followed by the A blood group.
32987167 Prevalence of ABO blood groups in different states and union territories of India were searched using different databases such as PubMed and Google Scholar. […] ABO blood group system is associated with poor prognosis of COVID-19 infection.
33015369 Some studies suggests that the ABO blood group could be a biological marker of susceptibility for the development of the disease. […] We collected data from patients admitted with COVID-19 infection who had ABO blood group recorded, and analyzed the incidence by groups, compared with the global population in Navarre, as well as their main complications and evolution.
33034095 In pairwise comparison among ABO blood types, AB donors had higher anti-RBD and anti-spike than O donors (p<0.05).
33057631 Here, we performed a retrospective cohort analysis of all Danish individuals tested for SARS-CoV-2 between 27 February 2020 and 30 July 2020, with a known ABO and RhD blood group, to determine the influence of common blood groups on virus susceptibility. […] ABO blood groups varied significantly between patients and the reference group, with only 38.41% (95% confidence interval [CI], 37.30-39.50) of the patients belonging to blood group O compared with 41.70% (95% CI, 41.60-41.80) in the controls, corresponding to a relative risk of 0.87 (95% CI, 0.83-0.91) for acquiring COVID-19. […] This study identifies ABO blood group as a risk factor for SARS-CoV-2 infection but not for hospitalization or death from COVID-19.
33057633 Therefore, we aimed to determine whether ABO blood groups are associated with different severities of COVID-19. […] We collected data pertaining to age, sex, comorbidities, dates of symptom onset, hospital admission, intensive care unit (ICU) admission, mechanical ventilation, continuous renal replacement therapy (CRRT), standard laboratory parameters, and serum inflammatory cytokines. […] National (N = 398 671; P = .38) and provincial (n = 62 246; P = .60) ABO blood group distributions did not differ from our cohort (n = 95).
33086161 ABO blood groups is a cheap and affordable test that can be immediately retrieved from COVID-19 patients at the diagnosis. […] We can conclude, on the diagnostic level, that ABO blood groups can be potentially used for risk stratification of affected COVID-19 patients, to anticipate the deterioration of patients at higher risk for complications.
33092632 Patients receive three doses (200 ml/day on 3 consecutive days) of ABO matched CCP.
33125158 Patient demographics and clinical and laboratory parameters were compared and analyzed. […] Statistical analysis identified increased transfusion reaction risk for ABO blood group B or Sequential Organ Failure Assessment scores of 12 to 13, and decreased risk within the age group of 80 to 89 years. […] Further studies are needed to confirm the clinical significance of ABO group B, age, and predisposing disease severity in the incidence of transfusion reaction events.
33164230 There is no evidence that racial/ethnic differences for COVID-19 are caused by ABO blood groups, use of angiotensin converting enzyme (ACE) inhibitors, or from amino acid substitutions in the SARS-CoV-2 spike protein.
33188185 Here, we use observational healthcare data on 14,112 individuals tested for SARS-CoV-2 with known blood type in the New York Presbyterian (NYP) hospital system to assess the association between ABO and Rh blood types and infection, intubation, and death.
33196159 To provide solid information about viral infection, disease, and body iron metabolism, the literature was surveyed for mutual correlations. […] There are further symptomatic hints that the ABO blood group system contributes to these correlations. […] Remarkably, the susceptibility to both the viral disease and iron dyshomeostasis can be traced back to the same gene loci of the ABO blood group system.
33196417 Several articles reported the existence of an association between ABO blood groups and COVID-19 susceptibility. […] No association was observed between ABO groups and mortality. […] ABO blood groups were also seen to represent important risk factors for COVID-19 severity and mortality. […] The association between the ABO blood groups and the susceptibility to acquire COVID-19 infection was confirmed in the group of blood donors. […] ABO blood groups were also associated to COVID-19 severity and mortality in the group of patients transfused during hospitalisation.
33226859 The ABO and rhesus (Rh) blood groups may influence risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. […] To determine whether ABO and Rh blood groups are associated with risk for SARS-CoV-2 infection and severe coronavirus disease 2019 (COVID-19) illness. […] All adults and children who had ABO blood group assessed between January 2007 and December 2019 and who subsequently had SARS-CoV-2 testing between 15 January and 30 June 2020.
33254482 Recent findings indicate that the ABO blood system modulates susceptibility and progression of infection, with type-A individuals being more susceptible to infection and/or manifestation of a severe condition. […] Based on this survey, we hypothesize that the correlation between the ABO blood system and susceptibility to SARS-CoV-2 infection can be presumably explained by the modulation of sialic acid-containing receptors distribution on host cell surface induced by ABO antigens through carbohydrate-carbohydrate interactions, which could maximize or minimize the virus Spike protein binding to the host cell.
33264276 We retrospectively analyzed the clinical data and laboratory test reports of patients with severe COVID-19 pneumonia who received a convalescent plasma transfusion. […] RESULTS A total of 24 patients with COVID-19 pneumonia who were transfused with ABO-compatible convalescent plasma were enrolled in the study. […] Other laboratory indicators such as white blood cells, high-sensitivity C-reactive protein, procalcitonin, alanine aminotransferase, and aspartate transaminase showed a decreasing trend after transfusion.
33296536 The aim of this study was to investigate the ABO and Rh blood group distribution and clinical characteristics in patients with COVID-19.
33309392 Several studies report that ABO blood group polymorphism may be related to COVID-19 susceptibility and clinical outcomes; however, the results are controversial. […] We conducted a systematic review and meta-analysis to investigate whether ABO blood groups are associated with increased COVID-19 morbidity and mortality.
33326874 Susceptibility to Covid-19 has been found to be associated with the ABO blood group, with O type individuals being at a lower risk. […] Here, we aimed to test the hypothesis that Covid-19 patients might have lower levels of ABO antibodies than non-infected individuals as they could offer some degree of protection. […] After showing that the viral spike protein harbors the ABO glycan epitopes when produced by cells expressing the relevant glycosyltransferases, like upper respiratory tract epithelial cells, we enrolled 290 patients with Covid-19 and 276 asymptomatic controls to compare their levels of natural ABO blood group antibodies. […] In this study, we showed that ABO antibody levels are significantly lower in Covid-19 patients compared to controls. […] These findings could indicate that patients with low levels of ABO antibodies are at higher risk of being infected.
33330542 Biological markers such as the ABO blood group system were amongst these factors that were proposed to be linked to the variability in the disease course and/or the prevalence of the infection among different groups. […] Contrary to the most acknowledged hypothesis, our results challenged the significance of this association and questioned the role of the ABO blood group system in dictating the severity of this disease. […] For future similar studies, we endorsed analyzing larger cohorts among different populations and we encouraged implementing more rigorous approaches to diminish the potential confounding effect of some underlying comorbidities and genetic variants that are known to be associated with the ABO blood group system.
33362545 For example, single-nucleotide polymorphisms (SNPs) in FGG, FGA, and F5 mediate increases in D-dimer and SNPs in ABO, CBS, CPS1 and MTHFR mediate differences in homocysteine levels, and SNPs in TDAG8 associate with Heparin-induced Thrombocytopenia. […] In this study, we aimed to uncover the genetic basis of the above conditions by examining genome-wide associations and tissue-specific gene expression to build a molecular network.
33407977 Thus, an association exists between SARS-CoV-2 and the ABO blood group distribution, which might be useful for fighting the COVID-19 pandemic.
33437242 To determine the association between ABO/Rh-D blood types and susceptibility to SARS-CoV-2 infection in Pakistan.
33447315 ABO blood types have been associated with disease susceptibility; however, evidence remains limited. […] Our aim was to determine the association between ABO/Rh blood type with disease susceptibility and mortality among admitted COVID-19 patients. […] Demographics and pertinent medical history were analyzed with respect to ABO/Rh blood type: between the cases and a control population; as well as with respect to mortality in the COVID-19 population in univariate analysis. […] Within the COVID-19 population, no mortality difference was appreciated between ABO groups (P = 0.312), but higher mortality was observed in Rh negative group (P = 0.01). […] Overall, ABO and Rh blood types do not have a significant relationship with susceptibility and mortality with COVID-19 infection in our population.
33453462 Genetic variation at a multigene cluster at chromosome 3p21.31 and the ABO blood group have been associated with the risk of developing severe COVID-19, but the mechanism remains unclear. […] The aim of this study was to examine whether chromosome 3p21.31 and the ABO variants are linked to the activation of the complement cascade in COVID-19 patients. […] The association between rs11385949 and SC5b-9 remained significant after adjustment for ABO and disease severity (P = 0.004) and further correction for C5a (P = 0.018).
33455936 These findings persisted across a range of risk factor-adjusted analyses accounting for major comorbidities, obesity, smoking, frailty and ABO blood group.
33478744 Our experience includes 2 simultaneous liver-kidney transplants, 1 ABO-incompatible LDLT, and 1 pediatric case (age 11 months).
33479990 Our series, although limited in size, showed a higher prevalence of blood group A among Covid-19 patients, statistically significant compared to ABO blood group distribution among Tunisian blood donors and among a control group of patients without Covid -19. these results are in line with data from the literature, particularly on larger series in China.
33493365 ABO blood group may affect risk of SARS-CoV-2 infection and/or severity of COVID-19. […] We sought to determine whether IgG, IgA and neutralizing antibody (nAb) to SARS-CoV-2 vary by ABO blood group. […] Among eligible convalescent plasma donors, ABO blood group was determined via agglutination of reagent A1 and B cells, IgA and IgG were quantified using the Euroimmun anti-SARS-CoV-2 ELISA, and nAb titres were quantified using a microneutralization assay. […] Differences in titre distribution were examined by ABO blood group using non-parametric Kruskal-Wallis tests. […] Distribution of nAb titres significantly differed by ABO blood group, whereas there were no significant differences in anti-spike IgA or anti-spike IgG titres by ABO blood group. […] Additional studies evaluating ABO blood groups and antibody titres that incorporate COVID-19 severity are needed.
33499228 Since the emergence of COVID-19, many publications have reported associations with ABO blood types. […] Moreover, as frequencies of ABO phenotypes are highly variable between populations or geographical areas, the ABO coefficient of variation, rather than the frequency of each individual phenotype is expected to determine impact of the ABO system on virus transmission. […] Accordingly, the ABO coefficient of variation correlates with COVID-19 prevalence. […] Overall, despite modest apparent risk differences between ABO subtypes, the ABO blood group system might play a major role in the COVID-19 pandemic when considered at the population level.
33501658 Information on the impact of ABO blood group (BG) on SARS-CoV-2 infections is conflicting (1-4).
33519277 However, significant differences (p < 0.001) were identified according to ABO blood groups, with those with type A blood presenting the highest rate of seropositivity (29.18%) compared with the other blood groups (12.65% for type B, 16.36% for type AB, and 15.11% for type O).
33520615 Here, the common SEIR model is generalized in order to show the dynamics of COVID-19 transmission taking into account the ABO blood group of the infected people.
33527398 Results were stratified by region, age, ethnicity, ABO groups and quantiles of material and social deprivation indices.
33529391 Reports on the association of the ABO phenotypes with infection by the SARS-CoV-2 virus have mostly come from countries with high infection rates. […] This study examined the possible association between SARS-CoV-2 infection and the ABO phenotype in Black Africa. […] The ABO distribution of patients was compared with that of a blood donor population.
33564039 At the same time, an association of the ABO blood group system with COVID-19 has also been highlighted: there is increasing evidence to suggest that non-O individuals are at higher risk of severe COVID-19 than O individuals. […] These findings imply that simultaneous suppression of ACE2 and ABO would be a promising approach for prevention or treatment of COVID-19. […] Notably, we have previously clarified that histone deacetylase inhibitors (HDACIs) are able to suppress ABO expression in vitro. […] Against this background, we further evaluated the effect of HDACIs on cultured epithelial cell lines, and found that HDACIs suppress both ACE2 and ABO expression simultaneously.
33565620 These donations were reviewed: first-time, repeat (donation ≤ 2 years), and lapsed (no donation > 2 years); sex; age; ethnicity; and ABO blood groups at high school and college drives.
33578447 Growing evidence suggests that ABO blood group may play a role in the immunopathogenesis of SARS-CoV-2 infection, with group O individuals less likely to test positive and group A conferring a higher susceptibility to infection and propensity to severe disease. […] The level of evidence supporting an association between ABO type and SARS-CoV-2/COVID-19 ranges from small observational studies, to genome-wide-association-analyses and country-level meta-regression analyses. […] ABO blood group antigens are oligosaccharides expressed on red cells and other tissues (notably endothelium). […] There are several hypotheses to explain the differences in SARS-CoV-2 infection by ABO type. […] ABO type-associated variations in angiotensin-converting enzyme-1 activity and levels of von Willebrand factor (VWF) and factor VIII could also influence adverse outcomes, notably in group A individuals who express high VWF levels.
33590936 Several studies indicated that the genetic variants of the SARS-CoV-2 entry mechanism related (Angiotensin converting enzymes, Transmembrane serine protease-2, Furin) and host innate immune response related genes (Interferons, Interleukins, Toll like receptors); HLA, ABO, 3p21.31 and 9q34.2 loci are critical host determinants related to Covid-19 severity.