GCA
grancalcin
Gene Context Sentence
Table 2. Analysis of context sentence of GCA gene in 3 abstracts.
| PMID | Gene Context Sentence |
|---|---|
| 33060304 | To identify shared and distinct features of giant cell arteritis (GCA) and coronavirus disease 2019 (COVID-19) to reduce diagnostic errors that could cause delays in correct treatment. […] Two systematic literature reviews determined the frequency of clinical features of GCA and COVID-19 in published reports. […] Headache was common in GCA but was also observed in COVID-19 (GCA 66%, COVID-19 10%). […] Jaw claudication or visual loss (43% and 26% in GCA, respectively) generally were not reported in COVID-19. […] Both diseases featured fatigue (GCA 38%, COVID-19 43%) and elevated inflammatory markers (C-reactive protein [CRP] elevated in 100% of GCA, 66% of COVID-19), but platelet count was elevated in 47% of GCA but only 4% of COVID-19 cases. […] Cough and fever were commonly reported in COVID-19 and less frequently in GCA (cough, 63% for COVID-19 vs 12% for GCA; fever, 83% for COVID-19 vs 27% for GCA). […] Gastrointestinal upset was occasionally reported in COVID-19 (8%), rarely in GCA (4%). […] Lymphopenia was more common in COVID-19 than GCA (53% in COVID-19, 2% in GCA). […] Alteration of smell and taste have been described in GCA but their frequency is unclear. […] Overlapping features of GCA and COVID-19 include headache, fever, elevated CRP and cough. […] We have designed a simple checklist to aid evidence-based evaluation of patients with suspected GCA. |
| 33364248 | FTA including CDS evaluation contributed to a substantial reduction of PVL in GCA by shortening the time to diagnosis and treatment initiation. |
| 33364547 | Our centre offers a fast-track assessment service for patients with suspected GCA and this service continued to operate during the coronavirus disease 2019 (COVID-19) pandemic. […] During and immediately following the peak of the COVID-19 pandemic in the UK we observed an increase in the number of patients diagnosed with GCA as well as an increased number of patients with visual complications. […] The electronic medical records of all patients referred for GCA fast-track assessment from January 2019 were reviewed. […] A complete list of patients undergoing temporal artery ultrasound and temporal artery biopsy for investigation of GCA dating back to 2015 was also available. […] In the 12 week period between April and June 2020, 24 patients were diagnosed with GCA. […] In contrast, during 2019, 28 new diagnoses of GCA were made in total and just 10% of patients suffered visual involvement. […] The number of patients diagnosed with GCA in April-June 2020 was nearly 5-fold that of the same time period the previous year. […] GCA diagnoses between April and June 2020 were supported by imaging (temporal artery ultrasound or CT-PET) in 72% of cases. […] However, our findings support the viral aetiopathogenesis hypothesis for GCA and demonstrate the importance of maintaining access to urgent rheumatology services during periods of healthcare disruption. |