FER
FER tyrosine kinase
Gene Context Sentence
Table 2. Analysis of context sentence of FER gene in 2 abstracts.
| PMID | Gene Context Sentence |
|---|---|
| 33527087 | We designed subunit vaccine candidates using self-assembling ferritin nanoparticles displaying one of two multimerized SARS-CoV-2 spikes: full-length ectodomain (S-Fer) or a C-terminal 70 amino-acid deletion (SΔC-Fer). […] Ferritin is an attractive nanoparticle platform for production of vaccines, and ferritin-based vaccines have been investigated in humans in two separate clinical trials. […] We confirmed proper folding and antigenicity of spike on the surface of ferritin by cryo-EM and binding to conformation-specific monoclonal antibodies. […] After a single immunization of mice with either of the two spike ferritin particles, a lentiviral SARS-CoV-2 pseudovirus assay revealed mean neutralizing antibody titers at least 2-fold greater than those in convalescent plasma from COVID-19 patients. […] Additionally, a single dose of SΔC-Fer elicited significantly higher neutralizing responses as compared to immunization with the spike receptor binding domain (RBD) monomer or spike ectodomain trimer alone. […] After a second dose, mice immunized with SΔC-Fer exhibited higher neutralizing titers than all other groups. […] Taken together, these results demonstrate that multivalent presentation of SARS-CoV-2 spike on ferritin can notably enhance elicitation of neutralizing antibodies, thus constituting a viable strategy for single-dose vaccination against COVID-19. |
| 33591793 | MethodA retrospective review was performed of consecutive patients referred to hospital with a clinical suspicion of COVID-19 over a period of 4 weeks. […] White cell count (WCC), neutrophils (NEU) and lymphocytes (LYM) were significantly lower, while lactate dehydrogenase (LDH) and ferritin (FER) were significantly higher, in the COVID group in comparison to CONTROL. […] Combining the WCC, LYM and FER results into a COVID Combined Blood Test (CCBT) had an AUC of 0.79. |