ISG15 ubiquitin like modifier
Gene Context Sentence
Table 2. Analysis of context sentence of ISG15 gene in 3 abstracts.
|PMID||Gene Context Sentence|
|32428392||Here, the biochemical activity of SARS-CoV-2 PLpro against ubiquitin and ISG15 substrates is evaluated revealing that the protease has a marked reduction in its ability to process K48 linked Ub substrates compared to its counter part in SARS-CoV. […] Additionally, its substrate activity more closely mirrors that of the PLpro from the Middle East respiratory syndrome coronavirus and prefers ISG15s from certain species including humans.|
|32429099||Both deubiquitinating and deISGylating functions involve the removal of the small regulatory polypeptides, ubiquitin and ISG15, respectively, from target proteins. […] ISG15 is a ubiquitin-like modifier with pleiotropic effects, typically expressed during the host cell immune response.|
|32553163||ISG15 is a ubiquitin-like modifier that also functions extracellularly, signaling through the LFA-1 integrin to promote interferon (IFN)-γ release from natural killer (NK) and T cells. […] The signals that lead to the production of extracellular ISG15 and the relationship between its two core functions remain unclear. […] We show that both epithelial cells and lymphocytes can secrete ISG15, which then signals in either an autocrine or paracrine manner to LFA-1-expressing cells. […] Microbial pathogens and Toll-like receptor (TLR) agonists result in both IFN-β-dependent and -independent secretion of ISG15, and residues required for ISG15 secretion are mapped. […] Intracellular ISGylation inhibits secretion, and viral effector proteins, influenza B NS1, and viral de-ISGylases, including SARS-CoV-2 PLpro, have opposing effects on secretion of ISG15. […] These results establish extracellular ISG15 as a cytokine-like protein that bridges early innate and IFN-γ-dependent immune responses, and indicate that pathogens have evolved to differentially inhibit the intracellular and extracellular functions of ISG15.|