Gene Context Sentence

Table 2. Analysis of context sentence of EPO gene in 7 abstracts.

PMID Gene Context Sentence
32522574 Finally, since erythropoietin (EPO) is an effective prophylactic treatment for AMS, this article reviews the potential benefits of implementing FDA-approved erythropoietin-based (EPO) drug therapies to counteract a variety of acute respiratory and non-respiratory (e.g. excessive inflammation of vascular beds) symptoms of SARS-CoV-2 infection.
32546125 We recap here evidence that supports the use of human recombinant erythropoietin (EPO) for ameliorating course and outcome of seriously ill COVID-19 patients. […] We delineate in brief sections, each introduced by a summary of respective COVID-19 references, how EPO may target a number of the gravest sequelae of these patients. […] EPO is expected to: (1) improve respiration at several levels including lung, brainstem, spinal cord and respiratory muscles; (2) counteract overshooting inflammation caused by cytokine storm/ inflammasome; (3) act neuroprotective and neuroregenerative in brain and peripheral nervous system.
32863034 This article summarizes the potential benefits of erythropoietin (EPO) in alleviating SARS-CoV-2 pathogenesis which is now called COVID-19. […] EPO exerts antiapoptotic and cytoprotective properties under various pathological conditions. […] With a high safety profile, EPO promotes the production of endothelial progenitor cells and reduce inflammatory processes through inhibition of the nuclear factor-κB (NF-κB) and JAK-STAT3 signaling pathways.
33118491 Erythropoietin (EPO) is a hypoxia-inducible hormone best known for its role in erythropoiesis. […] However, EPO also has anti-inflammatory and tissue-protective characteristics in multiple organs as summarised in this review. […] In the brain, EPO is upregulated by hypoxia, regulates ventilation and plays a key role in neuroprotection and neuroplasticity. […] Systemically administered EPO crosses the blood-brain-barrier, enhances neuroplasticity and improves cognitive functions in several disorders of the brain. […] Given this evidence, a trial is being planned to investigate whether EPO can improve the physiologic and neurologic outcome of COVID-19.
33521378 For example, HIF-2α may act on hemopoietin genes (heme-regulating genes); while HIF-1α acts on EPO.
33554466 Our study aimed to evaluate the relationship between COVID-19 and serum erythropoietin (EPO), hepcidin, and haptoglobin (Hpt) levels with disease severity, and other biochemical values. […] It was found that the mean EPO of the deceased was lower than the control group and the survived patient group (P = .035). […] In our study, while serum iron and hepcidin levels decreased in patients diagnosed with COVID-19, we found that EPO and Hpt levels were significantly lower in critical and deceased patient groups. […] Our study is the first study examining EPO and Hpt levels in patients diagnosed with COVID-19.
33584306 HIF prolyl hydroxylase inhibitors are known to boost endogenous erythropoietin (Epo) and activate erythropoiesis by stabilizing and activating the hypoxia inducible factor (HIF). […] Recombinant Epo treatment has anti-inflammatory and healing properties, and thus, very likely, will be beneficial for moderate to severe cases of COVID-19. […] However, HIF PHD inhibition may have a significantly broader effect, in addition to stimulating the endogenous Epo production.