Gene Context Sentence
Table 2. Analysis of context sentence of EMB gene in 4 abstracts.
|PMID||Gene Context Sentence|
|32529795||Since December 2019, the novel coronavirus SARS-CoV-2 has spread rapidly throughout China and keeps the world in suspense. […] Cardiovascular complications with myocarditis and embolism due to COVID-19 have been reported. […] Endomyocardial biopsies (EMBs) of 104 patients (mean age: 57.90 ± 16.37 years; left ventricular ejection fraction: 33.7 ± 14.6%, sex: n = 79 male/25 female) with suspected myocarditis or unexplained heart failure were analysed. […] EMB analysis included histology, immunohistochemistry, and detection of SARS-CoV-2 genomes by real-time reverse transcription polymerase chain reaction in the IKDT Berlin, Germany. […] Among 104 EMBs investigated, five were confirmed with SARS-CoV-2 infected by reverse real-time transcriptase polymerase chain reaction. […] Additionally, we investigated histopathological changes in myocardial tissue showing that the inflammatory process in EMBs seemed to permeate vascular wall leading to small arterial obliteration and damage. […] This is the first report that established the evidence of SARS-CoV-2 genomes detection in EMBs. […] EMB-based identification of the cause of myocardial injury may contribute to explain the different evolution of complicated SARS-CoV-2-infection and to design future specific and personalized treatment strategies.|
|33225579||At the first endomyocardial biopsy (EMB)-proven episode, she had concomitant pneumonia, and a temporary biventricular assist device implant was followed by complete and long-lasting cardiac recovery. […] Despite negative seriate nasopharyngeal swabs and EMB during hospitalization, an antibody positivity for severe acute respiratory syndrome coronavirus 2 was discovered after 4 weeks from discharge. […] This is the first report of an EMB-proven, immune-mediated (virus-negative) recurrence of fulminant myocarditis.|
|33299786||COVID 19 so far is not a known cardiotropic virus, and the term “myocarditis” should be exclusively used after EMB or autopsy proven diagnosis.|
|33594347||The aetiology is often viral and endomyocardial biopsy (EMB) is the gold standard for definite myocarditis. […] EMB was performed but could neither identify the virus in the cardiomyocytes, nor signs of inflammation.|