adaptor related protein complex 2 subunit mu 1

Gene Context Sentence

Table 2. Analysis of context sentence of AP2M1 gene in 1 abstracts.

PMID Gene Context Sentence
32923629 Here, we found a common YxxØ-motif of multiple viruses that exploits host AP2M1 for intracellular trafficking. […] A library chemical, N-(p-amylcinnamoyl)anthranilic acid (ACA), was identified to interrupt AP2M1-virus interaction and exhibit potent antiviral efficacy against a number of viruses in vitro and in vivo, including the influenza A viruses (IAVs), Zika virus (ZIKV), human immunodeficiency virus, and coronaviruses including MERS-CoV and SARS-CoV-2. […] YxxØ mutation, AP2M1 depletion, or disruption by ACA causes incorrect localization of viral proteins, which is exemplified by the failure of nuclear import of IAV nucleoprotein and diminished endoplasmic reticulum localization of ZIKV-NS3 and enterovirus-A71-2C proteins, thereby suppressing viral replication.