ADAMTS13


ADAM metallopeptidase with thrombospondin type 1 motif 13


ENTREZID: 11093 | Type: Protein Coding | Map: 9q34.2

OMIM: 607008 | 201450


Summary Entrez
This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]