VORICONAZOLE


DrugBank ID: db00582
DrugCentral: voriconazole
Synonymous :(r-(r,s))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1h-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol | (αr,βs)-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α(1h-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol | vcz | voriconazol | voriconazole | voriconazolum



Drug Sentece Context


Table 1. Analysis of context sentence of voriconazole gene in 2 abstracts.

pmid sentence
32376593 To investigate the effect of heat inactivation (56℃for 30 min) of SARS-CoV-2 on the results of therapeuticdrug monitoring (TDM) of voriconazole by liquid chromatography tandem mass spectrometry (LC-MS/MS). […] We collected clinical blood samples from voriconazole-treated patients in heparinized tubes and sterilized the surface of the tubes with 75% ethanol. […] The optimized method showed a high imprecision (with mean intra- and inter-day imprecisions of 3.59% and 2.81%, respectively) and a high accuracy (mean 97.37%) for detecting voriconazole in the inactivated samples at different concentration levels. […] The measured voriconazole concentrations in inactivated whole blood, inactivated plasma and the samples without inactivation all showed good linear correlations with correlation coefficients all greater than 0.99. […] Heat inactivation at 56 ℃ for 30 min combined with ethanol sample preparation only has limited effects to affect LC-MS-based voriconazole concentration measurement in whole blood samples collected in heparinized tubes, and can be used for therapeutic drug monitoring of voriconazole during the ongoing COVID-19 pandemic.