VERTEPORFIN
DrugBank ID: db00460
DrugCentral: verteporfin
Synonymous :verteporfin | verteporfina | vertéporfine | verteporfinum
Drug Sentece Context
Table 1. Analysis of context sentence of verteporfin gene in 1 abstracts.
| pmid | sentence |
|---|---|
| 33318880 | Here, we discovered that protoporphyrin IX (PpIX) and verteporfin, two FDA-approved drugs, completely inhibited the cytopathic effect produced by SARS-CoV-2 infection at 1.25 µmol/Land 0.31 µmol/L respectively, and their EC50 values of reduction of viral RNA were at nanomolar concentrations. […] The selectivity indices of PpIX and verteporfin were 952.74 and 368.93, respectively, suggesting broad margin of safety. […] Importantly, PpIX and verteporfin prevented SARS-CoV-2 infection in mice adenovirally transduced with human ACE2. […] Our study suggests that PpIX and verteporfin are potent antiviral agents against SARS-CoV-2 infection and sheds new light on developing novel chemoprophylaxis and chemotherapy against SARS-CoV-2. |