UROKINASE


DrugBank ID: db00013
DrugCentral: urokinase
Synonymous :kinase (enzyme-activating), uro-urokinase | tcuk | tissue culture urokinase | two-chain urokinase | urochinasi | urokinase | urokinasum | uroquinasa



Drug Sentece Context


Table 1. Analysis of context sentence of urokinase gene in 4 abstracts.

pmid sentence
32562843 Here, we highlight recent findings on the urokinase plasminogen activator (uPA)/uPA receptor (uPAR) system that suggest its potential role as a main orchestrator of fatal progression to pulmonary, kidney, and heart failure in patients with coronavirus.
32612430 Dysregulation of the urokinase pathway, cleavage of the SARS-CoV-2 Spike protein by FXa and FIIa, and consumption coagulopathy were the proposed mechanisms of the coagulation dysfunction in COVID-19.
32613288 In this population, soluble urokinase plasminogen activator receptor (suPAR) could serve as a quick triage test and independent marker of clinical severity, hospital and intensive care unit admission, complications, and mortality.
32829149 Importantly, many related human proteases have 80% or higher identity with TMPRSS2 in the S1-S1’ subsites, with plasminogen and urokinase-type plasminogen activator (uPA) having 95% identity.
32963090 The urokinase receptor system is a key regulator of the intersection between inflammation, immunity, and coagulation, and soluble urokinase plasminogen activator receptor (suPAR) has been identified as an immunologic risk factor for AKI.