URIDINE
DrugBank ID: db02745
DrugCentral: uridine
Synonymous :uridina
Drug Sentece Context
Table 1. Analysis of context sentence of uridine gene in 5 abstracts.
| pmid | sentence |
|---|---|
| 32462970 | Comparative structural analysis showed the stronger binding of EndoU to Glisoxepide and Idarubicin than uridine monophosphate (UMP). |
| 32552462 | From the observed binding energy and the binding interactions, glyasperin A showed high affinity towards Nsp15 endoribonuclease with uridine specificity, while glycyrrhizic acid was found to be best suited for the binding pocket of spike glycoprotein and also prohibited the entry of the virus into the host cell. |
| 32894566 | The use of uridine, which preserves the structure of pulmonary alveoli and the air-blood barrier of the lungs in the course of experimental severe hypoxia, and dihydroquercetin, an effective free radical scavenger, is promising for the treatment of COVID-19. |
| 33085541 | They are likely to be caused by the cytosine-to-uridine deamination system in hosts. |
| 33125064 | Furthermore, intermediary metabolism is built on compulsory steps of synthesis and salvage of cytosine-based metabolites via uridine triphosphate that keep limiting CTP availability. |
| 33161087 | Of the total 20,163 instances of polymorphism detected across global genomes, 12,594 and 7569 involved transitions and transversions, predominated by cytidine-to-uridine and guanosine-to-uridine conversions, respectively. |
| 33267713 | Noticeably, several of the uncovered drugs can be readily tested, like didanosine, methotrexate, vitamin A, nicotinamide, valproic acid, uridine, and flucloxacillin. |
| 33297848 | Most of the uridine esters showed better results than that of the HCQ. […] Overall, the present study might be useful for the development of uridine-based novel MDR antimicrobial and COVID-19 drugs. |
| 33504779 | Nsp15, a uridine specific endoribonuclease conserved across coronaviruses, processes viral RNA to evade detection by host defense systems. […] The cryo-EM reconstructions, combined with biochemistry, mass spectrometry, and molecular dynamics, expose molecular details of how critical active site residues recognize uridine and facilitate catalysis of the phosphodiester bond. |
| 33564093 | SARS-CoV-2 Nsp15 is a uridine-specific endoribonuclease with C-terminal catalytic domain belonging to the EndoU family that is highly conserved in coronaviruses. […] Here we report the first structures with bound nucleotides and show how the enzyme specifically recognizes uridine moiety. […] In addition to a uridine site we present evidence for a second base binding site that can accommodate any base. […] The structure with a transition state analog, uridine vanadate, confirms interactions key to catalytic mechanisms. […] Using crystallography, biochemical, and whole-cell assays, we demonstrate that Tipiracil inhibits SARS-CoV-2 Nsp15 by interacting with the uridine binding pocket in the enzyme’s active site. |