TYROSINE


DrugBank ID: db00135
DrugCentral: tyrosine
Synonymous :(−)-α-amino-p-hydroxyhydrocinnamic acid | (2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid | (s)-(-)-tyrosine | (s)-2-amino-3-(p-hydroxyphenyl)propionic acid | (s)-3-(p-hydroxyphenyl)alanine | (s)-alpha-amino-4-hydroxybenzenepropanoic acid | (s)-tyrosine | (s)-α-amino-4-hydroxybenzenepropanoic acid | 4-hydroxy-l-phenylalanine | l-tyrosin | l-tyrosine | tirosina | tyr | tyrosine | tyrosinum | y



Drug Sentece Context


Table 1. Analysis of context sentence of tyrosine gene in 8 abstracts.

pmid sentence
32345646 As the SARS-CoV-2 (COVID19) pandemic spreads and the number of Bruton’s tyrosine kinase inhibitor (BTKi)-treated COVID19 affected patients grows, we must consider the pros and cons of BTKi discontinuation for our patients.
32387301 The most promising drugs might be: Ruxolitinib, a JAK1/2 inhibitor, with a rapid and powerful anti-cytokine effect, tyrosine kinase inhibitors (TKIs), with their good anti-inflammatory properties, and perhaps the anti-Cd26 antibody Begelomab.
32392389 We studied the clinical course of COVID-19 in five hospitalized patients with autoimmune MG (four with acetylcholine receptor antibodies, one with muscle-specific tyrosine kinase antibodies) between April 1, 2020-April 30-2020.
32392559 The biology of each leukemia and its corresponding treatment with conventional intensive chemotherapy, with or without targeted therapies (venetoclax, FLT3 inhibitors, IDH1/2 inhibitors, Bruton’s tyrosine kinase inhibitors), introduce additional layers of complexity during COVID-19 high-risk periods.
32395702 Many viruses not only use growth factor receptors to physically attach to the cell surface and internalize, but also divert receptor tyrosine kinase signaling in order to replicate.
32424293 There was also an increased risk of developing COVID-19 in subjects in advanced phase CML (P = 0.004) even when they achieved a complete cytogenetic response or major molecular response at the time of exposure to SARS-CoV-2. 1 of 21 subjects receiving 3rd generation tyrosine kinase-inhibitor (TKI) developed COVID-19 versus 3 of 346 subjects receiving imatinib versus 0 of 162 subjects receiving 2nd generation TKIs (P = 0.096).
32479682 Uterine artery pulsatility index (UtAPI) and angiogenic factors (soluble fms-like tyrosine kinase-1/placental growth factor [sFlt-1/PlGF]) were assessed in women with suspected PE.
32489026 GO annotation analysis suggested that Qingwen Baidu Yin Decoction may exert therapeutic effects by regulating protein phosphorylation, cell response to cytokine stimulation, cell proliferation, inflammatory response, transmembrane receptor protein tyrosine kinase signaling pathway, and cytokine-mediated signaling pathways.
32503877 Bruton tyrosine kinase (BTK) regulates macrophage signaling and activation.
32583086 This review addresses some of the pathways leading to endothelial derangement, such as complement, HIF-1α, and ABL tyrosine kinases.
32584418 His white blood count (WBC) was 187×109 /L and bone marrow (Figure 1A & 1C) examination revealed normal karyotype AML with a fms related receptor tyrosine kinase 3 (FLT3) internal tandem duplication (ITD), wild-type NPM1 and no additional mutations on a next-generation sequencing panel.