TRYPTOPHAN


DrugBank ID: db00150
DrugCentral: tryptophan
Synonymous :(2s)-2-amino-3-(1h-indol-3-yl)propanoic acid | (s)-alpha-amino-beta-(3-indolyl)-propionic acid | (s)-tryptophan | (s)-α-amino-1h-indole-3-propanoic acid | l-(-)-tryptophan | l-(−)-tryptophan | l-tryptophan | l-β-3-indolylalanine | triptofano | trp | tryptophan | tryptophane | tryptophanum | w



Drug Sentece Context


Table 1. Analysis of context sentence of tryptophan gene in 1 abstracts.

pmid sentence
32535509 INFs are known to shift the metabolism of tryptophan (TRP) away from its role as a precursor of serotonin.
32559180 Targeted and untargeted metabolomics analyses identified altered tryptophan metabolism into the kynurenine pathway, which regulates inflammation and immunity. […] Indeed, these changes in tryptophan metabolism correlated with interleukin-6 (IL-6) levels.
32636755 Here, we briefly discuss the potentially multiple, synergistic mechanisms whereby tocilizumab might exert therapeutic activity, mostly focusing on the production of tryptophan-derived catabolites that would result from blockade of IL-6 signaling, as contextualized to the cytokine storm occurring in COVID-19 patients.
32670298 We also identified the higher expression of genes involved in metabolic pathways including heme biosynthesis, oxidative phosphorylation and tryptophan metabolism.
32806897 Key discriminant metabolites included markers of inflammation including elevated α-1-acid glycoprotein and an increased kynurenine/tryptophan ratio.
32853469 NAD can be synthesized de novo starting with tryptophan, or from salvage pathways starting with NAD precursors like nicotinic acid (NA), nicotinamide (NAM) or nicotinamide riboside (NR), referred to as niacin/B3 vitamins, arising from dietary supply or from cellular NAD catabolism.
33033346 We identified the role of the cytosine and tryptophan-nicotinamide pathways in this discrimination. […] We have highlighted the role of the tryptophan-nicotinamide pathway clearly linked to inflammatory signals and microbiota, and the involvement of cytosine, previously described as a coordinator of cell metabolism in SARS-CoV-2.
33042532 The purpose of this study was to review these coronaviruses, especially SARS (because of its very similar gene sequence to the 2019-nCoV or SARS-CoV-2), from the perspective of appropriate approaches to food production technology, including following good food safety practices in food production lines; avoidance of underheating in the processing of swine and the other meat products; uncertainty about the safety of frozen or refrigerated meat products; providing unfavorable environmental conditions for coronavirus survival (minimum heat treatment, e.g., low-temperature long time and greater for liquid food products, pH ≤ 3, minimum storage relative humidity); production of industrial foods fortified and enriched with vitamin D, C, B3, K, amino acid L-tryptophan, nicotinamide adenine dinucleotide (NAD+), and tannins; and preventing the production of industrial foods fortified or enriched with mineral supplements that participate in the Fenton reaction in the human body.