TRYPSIN
DrugBank ID: db11237
DrugCentral: trypsin
Synonymous :tripsina
Drug Sentece Context
Table 1. Analysis of context sentence of trypsin gene in 3 abstracts.
| pmid | sentence |
|---|---|
| 32160149 | We found that the virus replicates to high titer in Vero-CCL81 cells and Vero E6 cells in the absence of trypsin. |
| 32335456 | While the binding to host cell receptor is the first step of infection, the entrance of the virus into the cell needs the cleavage of S1-S2 subunits to expose S2 for fusion to cell membrane via host proteases including cathepsins, cell surface transmembrane protease/serine (TMPRSS) proteases, furin, trypsin and factor Xa. |
| 32462744 | Proteins from inactivated virus samples were extracted, digested with trypsin, and the resulting peptides were identified by data-dependent acquisition tandem mass spectrometry. |
| 32537610 | Aprotinin is a nonspecific protease inhibitor especially of trypsin, chymotrypsin, plasmin, and kallikrein, and it is many years in clinical use. |
| 32639183 | Inter-α-trypsin inhibitor (IαI) family members are ancient and unique molecules that have evolved over several hundred million years of vertebrate evolution. |
| 32675285 | Moreover, we found that TMPRSS11A activation cleavage occurred before the protein reached the cell surface, as indicated by studies with trypsin digestion to remove cell surface proteins, treatment with cell organelle-disturbing agents to block intracellular protein trafficking, and analysis of a soluble form of TMPRSS11A without the transmembrane domain. |
| 32846910 | The recombinant vaccine candidate virus actively replicated and spread within cells independently of exogenous trypsin. |
| 32870433 | Thrombin is a trypsin-like serine protease with multiple physiological functions. |
| 32972339 | There are other proteases with varying spatiotemporal locations that may be important for viral entry and subsequent replication inside the cells, and these include trypsin, furin and cathepsins. […] In this report, we discuss the tentative therapeutic role of inhibitors of TMPRSS2, cathepsin, trypsin, furin, plasmin, factor X and elastase in infection caused by SARS-CoV-2. |
| 32975843 | The CZ-MD provides a protective glycerol barrier containing cod trypsin as an ancillary component. |